CN108743766A - A kind of Chrysosplenium nudicaule Bunge excrementum pteropi product and preparation method thereof - Google Patents
A kind of Chrysosplenium nudicaule Bunge excrementum pteropi product and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chrysosplenium nudicaule Bunge excrementum pteropi products and preparation method thereof, include the material component of following parts by weight：2-4 parts of Chrysosplenium nudicaule Bunge, 4-8 parts of walnut kernel, 2-5 parts of christina loosestrife herb, 1-3 parts of Wang Anyi, 1.5-3 parts of kiss-me, 2-4 parts of the root of Chinese clematis, hangs 3-6 parts of pumpkin vine, 1-2 parts of water chestnut, 0.5-2 parts of pure sesame oil at 3-5 parts of excrementum pteropi.Raw material type of the present invention is few, it securely and reliably has no toxic side effect for pure natural raw material, selected medicinal material compatibility is suitable, meet traditional Chinese medicine and pharmacy and modern medical theory, according to the combination principle of monarch, reaches unexpected therapeutic effect, using convenient source, convenient for materials, cheap, preparation method is simple.Chrysosplenium nudicaule Bunge excrementum pteropi product prepared by the application, after being taken according to the course for the treatment of, has apparent therapeutic effect for gall stone.
Description
Technical field
The invention belongs to field of health care food more particularly to a kind of Chrysosplenium nudicaule Bunge excrementum pteropi product and preparation method thereof.
Background technology
Gall stone is also known as cholelithiasis, refers to the disease that biliary system includes generation calculus in gall-bladder or bile duct；Infection of biliary tract
It is to belong to common disease.It is divided into cholecystolithiasis and calculus of bile duct by site of pathological change.After calculus is formed in gall-bladder, courage can be stimulated
Capsule mucous membrane can not only cause the chronic inflammation of gall-bladder, but also after Incarcerated stone is in neck of gallbladder or cystic duct, can also cause
Secondary infection leads to the acute inflammation of gall-bladder.Chronic stimulation due to calculus to gallbladder mucosa, it is also possible to lead to the hair of gallbladder cancer
It is raw, there is the incidence for reporting such gallbladder cancer up to 1%~2%.
The reason of causing gall stone include mainly：1, bile component changes：It is the most common reason that gall stone is formed.
Bile is mainly made of cholate, cholesterol, inorganic salts etc., if cholesterol concentration is excessively high, can lead to bile sedimentation, calculus；
2, cholestasis；3, it infects：Such as ascariasis of biliary tract；4, biliary motility dysfunction：Such as breakfast skipping, diabetes patient.
The method of prior art treatment gall stone be excise one's gallbladder or it is minimally invasive take stone, make patient not only and to bear the pain of operation
Hardship, while having lacked a courage compared with normal person, on life in the future, there are prodigious influences.
Number of patent application provides for 201210560147.7 patent of invention and discloses the drug of row's gall stone a kind of, main
Side is composed of the following components：Olive oil, lemon juice；Subsidiary formula consists of the following medicinal materials：Radix bupleuri, Radix Salviae Miltiorrhizae, corydalis tuber, rhizoma cyperi, river Dong,
Radix Angelicae Sinensis, Radix Paeoniae Alba, product shell, Radix Curcumae, fingered citron, astragali, chrysanthemum, felwort, rabdosia lophanthide, oriental wormwood, Asiatic plantain, desmodium, cordate houttuynia, pool
Rush down, the membrane of a chicken's gizzard, talcum, Radix Glycyrrhizae.The invention compared with prior art, using the main side that makes after olive oil and lemon juice mixing,
After patient on an empty stomach takes main side, calculus is excreted through enteron aisle by a night, but the patent raw material type is various, prepares
It is more complicated.
Invention content
In order to overcome the above problems of the prior art, a kind of Chrysosplenium nudicaule Bunge excrementum pteropi product is provided, use is pure natural
Raw material securely and reliably has no toxic side effect, and selected medicinal material compatibility is suitable, meets traditional Chinese medicine and pharmacy and modern medical theory, according to monarch
Minister helps the combination principle made, reaches unexpected therapeutic effect for gall stone symptom, using convenient source, convenient for drawing materials,
It is cheap, while preparation method is simple.
A kind of Chrysosplenium nudicaule Bunge excrementum pteropi product, includes the material component of following parts by weight：2-4 parts of Chrysosplenium nudicaule Bunge, excrementum pteropi 3-5
Part, 1.5-3 parts of kiss-me, 2-4 parts of the root of Chinese clematis, hangs pumpkin at 4-8 parts of walnut kernel, 2-5 parts of christina loosestrife herb, 1-3 parts of Wang Anyi
3-6 parts climing, 1-2 parts of water chestnut, 0.5-2 parts of pure sesame oil.
Preferably, include the material component of following parts by weight：2 parts of Chrysosplenium nudicaule Bunge, 3 parts of excrementum pteropi, 4 parts of walnut kernel, great Jin
2 parts of money grass, 1.5 parts of kiss-me, 2 parts of the root of Chinese clematis, hangs 3 parts of pumpkin vine, 1 part of water chestnut, 0.5 part of pure sesame oil at 1 part of Wang Anyi.
In any of the above-described scheme preferably, include the material component of following parts by weight：3 parts of Chrysosplenium nudicaule Bunge, 4 parts of excrementum pteropi,
6 parts of walnut kernel, 2 parts of Wang Anyi, 2 parts of kiss-me, 3 parts of the root of Chinese clematis, hangs 4 parts of pumpkin vine, water chestnut 1.5 at 4 parts of christina loosestrife herb
Part, 1 part of pure sesame oil.
In any of the above-described scheme preferably, include the material component of following parts by weight：4 parts of Chrysosplenium nudicaule Bunge, 5 parts of excrementum pteropi,
8 parts of walnut kernel, 5 parts of christina loosestrife herb, 3 parts of Wang Anyi, 3 parts of kiss-me, 4 parts of the root of Chinese clematis, hang 6 parts of pumpkin vine, 2 parts of water chestnut,
2 parts of pure sesame oil.
In any of the above-described scheme preferably, the dosage form of the Chrysosplenium nudicaule Bunge excrementum pteropi product be powder, pulvis, tablet,
Any one in granula, decoction, oral solution, honey ointment body, honeydew, beverage or tea bag preparation.
In any of the above-described scheme preferably, the dosage form of the Chinese medicine composition is powder, pulvis, tablet, granule, soup
Any one in agent, oral solution, honey ointment body, honeydew, beverage or tea bag preparation.
The present invention also provides the preparation method of above-mentioned Chrysosplenium nudicaule Bunge excrementum pteropi product, Chrysosplenium nudicaule Bunge excrementum pteropi product is tablet, system
Preparation Method includes the following steps：
(1) by Chrysosplenium nudicaule Bunge, excrementum pteropi, walnut kernel, christina loosestrife herb, Wang Anyi, kiss-me, the root of Chinese clematis, hang pumpkin
It is weighed after crushing workshop and crushing according to the ratio after climing, water chestnut raw material processing；
(2) mixes load weighted raw material and pure sesame oil in step (1) in mixing machine, and setting incorporation time turns
Speed releases raw material after mixing；
(3) raw material mixed is carried out tabletting by using tablet press machine；
(4) it is packed after tablettings, after the completion of packaging, the qualified storage of product laboratory detection.
Preferably, it is needed to Chrysosplenium nudicaule Bunge, excrementum pteropi, walnut kernel, christina loosestrife herb, Wang Buliu before step (1) sieving
Row seed, kiss-me, the root of Chinese clematis, hang pumpkin vine, water chestnut is tested, after the assay was approved according to the ratio crush workshop ultramicro grinding.
In any of the above-described scheme preferably, it is ultramicro grinding that the step (1), which crushes, Ultramicro-powder grain size after ultramicro grinding
It is 10~60 μm.
In any of the above-described scheme preferably, ultramicro grinding, the air-flow pressure of airslide disintegrating mill are carried out using airslide disintegrating mill
Power is 600~8000kPa, and charging rate is 180~200rmin-1, grade frequency be 20~30Hz, grinding time be 20~
30min obtains Ultramicro-powder.
In any of the above-described scheme preferably, the incorporation time in step (2) is 20-30 minutes, 20 revs/min.
In any of the above-described scheme preferably, 3.8 thousand Ns of tablet press machine pressure in the step (3), loading 5mm, every
Net content is between 1.05-1.10 grams.
In any of the above-described scheme preferably, the specific practice of step (4) packaging is：Per bottled 60 Chinese medicine groups
Object tablet is closed, is sealed later, seal and bottle is transmitted to outer packing workshop has been labelled, vanning.
Using Chrysosplenium nudicaule Bunge, excrementum pteropi, walnut kernel, christina loosestrife herb, Wang Anyi, kiss-me, Wheeling in the application formula
Celestial being hangs pumpkin vine, water chestnut, pure sesame oil as raw material.
Pure sesame oil, decompression containing unsaturated fatty acid are easily decomposed and absorb by human body beneficial to heart and vascular health
And utilization, promote the metabolism of cholesterol, prevent bile sedimentation, the deposit in arterial blood tube wall is removed, to play softening blood
Pipe, prevention move the effect of fat hardening, relax bowel.
Water chestnut can promote growth in humans to develop and maintain the needs of physiological function, and there have to the development of tooth bone to be very big good
Place, while the metabolism of internal sugar, fat, three big substance of protein can be promoted, acid-base balance is adjusted, therefore water chestnut is suitable for children
It is edible.There is certain effect to reducing blood pressure, also has preventive and therapeutic effect to cancerous swelling.There is moistening lung for removing phlegm, the effect of promoting the production of body fluid.Contained starch and
Crude protein can promote intestinal peristalsis, contained crude fat to increase the effect to relax bowel.There are the good effects of clearing heat-fire, both
Can clearing heat and promoting fluid, and can supplement the nutrients, most preferably be used for the patient that has a fever, also there is removing pattogenic heat from the blood and toxic material from the body, diuresis defaecation, Cleering damp and dissolving phlegm, disappear
Eat de-swelling and other effects.
Pumpkin vine is hung, there is small lint on pumpkin vine surface, also contains many crude fibres, so the wriggling for stomach is
Helpful.It is also the generation that can prevent calculus simultaneously.Pumpkin vine also contains many trace element and some vitamins,
For example contain calcium constituent, P elements and vitamin c and vitamin b etc..In addition to this, also contain the substance there are many amino acid,
So nutritive value is very high.Patient for liver and spleen weakness is very good.
The root of Chinese clematis, pungent, salty, temperature.Return bladder warp.Wind-damp dispelling is removed obstruction in channels to relieve pain, and disappear bone sticking.
Wang Anyi, promoting circulation of blood promoting menstruation expedite the emergence of lower breast, activating blood circulation and reducing swelling, healing up sore and subduing swelling.
Christina loosestrife herb, heat-clearing, dampness removing are subsided a swelling, removing toxic substances.Yellow River harnessing subcutaneous ulcer, oedema, gall stone, kidney stone, vesical calculus, gastric disorder causing nausea
It is dysphagic, traumatic injury, furuncle swelling toxin.
Kiss-me, wind-dispelling, heat-clearing, removing pattogenic heat from the blood and toxic material from the body.Control rubella；Eczema, tympanitis, erysipelas, cough are spitted blood, lung carbuncle, uterine bleeding,
Haemorrhoids.
Excrementum pteropi, sweet, warm.Enter Liver Channel.It is promoting blood circulation, removing blood stasis and analgesics, dissolving stasis and hemostasis.
The effect of Chrysosplenium nudicaule Bunge：It is cold, it is bitter.Clearing heat secreting bile, under laxative.For gallbladder-heat disease, have a fever, headache, cholecystitis, courage knot
Stone.To rush down gallbladder-heat disease common drug.
Walnut kernel is the fruit of juglandaceae plant.Walnut kernel contains abundant nutrient, per hectogram containing protein 15~
20 grams, 60~70 grams of fat, 10 grams of carbohydrate；And contain various trace elements and the mineral such as calcium needed by human, phosphorus, iron
The multivitamins such as matter and carrotene, riboflavin.The fatty main component of institute is linoleic acid fat in walnut, after food
Not but not cholesterol is made to increase, moreover it is possible to reduce absorption of the enteron aisle to cholesterol.
Advantageous effect
A kind of Chrysosplenium nudicaule Bunge excrementum pteropi product of present invention offer and preparation method thereof, includes the material component of following parts by weight：
2-4 parts of Chrysosplenium nudicaule Bunge, 3-5 parts of excrementum pteropi, 4-8 parts of walnut kernel, 2-5 parts of christina loosestrife herb, 1-3 parts of Wang Anyi, kiss-me 1.5-
3 parts, 2-4 parts of the root of Chinese clematis, hang 3-6 parts of pumpkin vine, 1-2 parts of water chestnut, 0.5-2 parts of pure sesame oil.Raw material type of the present invention is few, is pure
Natural material securely and reliably has no toxic side effect, and selected medicinal material compatibility is suitable, meets traditional Chinese medicine and pharmacy and modern medical theory, root
According to the combination principle of monarch, reach unexpected therapeutic effect, cheap convenient for materials using convenient source, system
Preparation Method is simple.Chrysosplenium nudicaule Bunge excrementum pteropi product prepared by the application, after being taken according to the course for the treatment of, has the symptom of gall stone bright
Aobvious therapeutic effect.
Specific implementation mode
In order to be best understood from technical scheme of the present invention and advantage, below by way of specific implementation mode, to the present invention do into
One step explanation.
Embodiment 1.1
A kind of Chrysosplenium nudicaule Bunge excrementum pteropi product, includes the material component of following parts by weight：2 parts of Chrysosplenium nudicaule Bunge, 3 parts of excrementum pteropi, core
4 parts of peach kernel, 2 parts of christina loosestrife herb, 1 part of Wang Anyi, 1.5 parts of kiss-me, 2 parts of the root of Chinese clematis, hang 3 parts of pumpkin vine, 1 part of water chestnut,
0.5 part of pure sesame oil.
Above-mentioned Chrysosplenium nudicaule Bunge excrementum pteropi product is tablet, and preparation method includes the following steps：
Step (1), by Chrysosplenium nudicaule Bunge, excrementum pteropi, walnut kernel, christina loosestrife herb, Wang Anyi, kiss-me, the root of Chinese clematis, hang south
After melon is climing, water chestnut raw material pre-processes, crushing is dried at normal temperatures, the said goods examine qualified raw material Chrysosplenium nudicaule Bunge, five spirits
Fat, walnut kernel, christina loosestrife herb, Wang Anyi, kiss-me, the root of Chinese clematis, hang pumpkin vine, water chestnut by technology preparation proportioning crushing
Workshop carries out ultramicro grinding using airslide disintegrating mill, and the stream pressure of airslide disintegrating mill is 600~8000kPa, and charging rate is
180~200rmin-1, grade frequency is 20~30Hz, and grinding time is 20~30min, obtains Ultramicro-powder, surpasses after ultramicro grinding
Grain size of micropowder is 10~60 μm, and all materials electronic scale between weighing is weighed after crushing；Pretreatment of raw material includes will be golden
Waist grass, walnut kernel, christina loosestrife herb, Wang Anyi, kiss-me, the root of Chinese clematis, hangs pumpkin vine, water chestnut respectively in brine at excrementum pteropi
In impregnated, brine strength 5-10%, cleaning, pull out and dried under rear room temperature.
Step (2) is transmitted to groove profile compound department, workshop temperature the load weighted raw material in workshop is weighed by sterile transferring window
14 degree, humidity 30% are spent, raw material and pure sesame oil dispensing in CH-200 mixing machines, incorporation time is 20-30 minutes, 20 turns/
Point, incorporation time is set by technological requirement, material is released with stainless steel barrel；When mixing, it is passed through nitrogen, protects active ingredient.
Step (3), will mix raw material by sterile transferring window be transmitted to tabletting workshop carry out tabletting, tablet press machine model
ZPW-19B, 3.8 thousand Ns of tablet press machine pressure, loading 5mm, every 1 gram of net content check a net content in every 10 minutes,
Net content is asked to reach between 1.05-1.10 grams；
Step (4), every bottled 60 Chinese medicine composition tablets, seal, have sealed bottle being transmitted to outsourcing entrucking later
Between labelled, case；The bottle labelling that inner packing workshop is transmitted, label print the date of manufacture, post label and are packed into greatly
Case, per 120 bottles of box installed；
Step (5), the qualified storage of product laboratory detection.
Embodiment 2
A kind of Chrysosplenium nudicaule Bunge excrementum pteropi product, includes the material component of following parts by weight：3 parts of Chrysosplenium nudicaule Bunge, 4 parts of excrementum pteropi, core
6 parts of peach kernel, 4 parts of christina loosestrife herb, 2 parts of Wang Anyi, 2 parts of kiss-me, 3 parts of the root of Chinese clematis, hang 4 parts of pumpkin vine, 1.5 parts of water chestnut,
1 part of pure sesame oil.
Above-mentioned Chrysosplenium nudicaule Bunge excrementum pteropi product is tablet, and preparation method includes the following steps：
Step (1), by Chrysosplenium nudicaule Bunge, excrementum pteropi, walnut kernel, christina loosestrife herb, Wang Anyi, kiss-me, the root of Chinese clematis, hang south
After melon is climing, water chestnut raw material pre-processes, crushing is dried at normal temperatures, the said goods examine qualified raw material Chrysosplenium nudicaule Bunge, five spirits
Fat, walnut kernel, christina loosestrife herb, Wang Anyi, kiss-me, the root of Chinese clematis, hang pumpkin vine, water chestnut by technology preparation proportioning crushing
Workshop carries out ultramicro grinding using airslide disintegrating mill, and the stream pressure of airslide disintegrating mill is 600~8000kPa, and charging rate is
180~200rmin-1, grade frequency is 20~30Hz, and grinding time is 20~30min, obtains Ultramicro-powder, surpasses after ultramicro grinding
Grain size of micropowder is 10~60 μm, and all materials electronic scale between weighing is weighed after crushing；Pretreatment of raw material includes will be golden
Waist grass, walnut kernel, christina loosestrife herb, Wang Anyi, kiss-me, the root of Chinese clematis, hangs pumpkin vine, water chestnut respectively in brine at excrementum pteropi
In impregnated, brine strength 5-10%, cleaning, pull out and dried under rear room temperature.
Step (2) is transmitted to groove profile compound department, workshop temperature the load weighted raw material in workshop is weighed by sterile transferring window
14 degree, humidity 30% are spent, raw material and pure sesame oil dispensing in CH-200 mixing machines, incorporation time is 20-30 minutes, 20 turns/
Point, incorporation time is set by technological requirement, material is released with stainless steel barrel；When mixing, it is passed through nitrogen, protects active ingredient.
Step (3), will mix raw material by sterile transferring window be transmitted to tabletting workshop carry out tabletting, tablet press machine model
ZPW-19B, 3.8 thousand Ns of tablet press machine pressure, loading 5mm, every 1 gram of net content check a net content in every 10 minutes,
Net content is asked to reach between 1.05-1.10 grams；
Step (4), every bottled 60 Chinese medicine composition tablets, seal, have sealed bottle being transmitted to outsourcing entrucking later
Between labelled, case；The bottle labelling that inner packing workshop is transmitted, label print the date of manufacture, post label and are packed into greatly
Case, per 120 bottles of box installed；
Step (5), the qualified storage of product laboratory detection.
Embodiment 3
A kind of Chrysosplenium nudicaule Bunge excrementum pteropi product, includes the material component of following parts by weight：4 parts of Chrysosplenium nudicaule Bunge, 5 parts of excrementum pteropi, core
8 parts of peach kernel, 3 parts of Wang Anyi, 3 parts of kiss-me, 4 parts of the root of Chinese clematis, hangs 6 parts of pumpkin vine, is 2 parts of water chestnut, pure 5 parts of christina loosestrife herb
2 parts of sesame oil.
Above-mentioned Chrysosplenium nudicaule Bunge excrementum pteropi product is tablet, and preparation method includes the following steps：
Step (1), by Chrysosplenium nudicaule Bunge, excrementum pteropi, walnut kernel, christina loosestrife herb, Wang Anyi, kiss-me, the root of Chinese clematis, hang south
After melon is climing, water chestnut raw material pre-processes, crushing is dried at normal temperatures, the said goods examine qualified raw material Chrysosplenium nudicaule Bunge, five spirits
Fat, walnut kernel, christina loosestrife herb, Wang Anyi, kiss-me, the root of Chinese clematis, hang pumpkin vine, water chestnut by technology preparation proportioning crushing
Workshop carries out ultramicro grinding using airslide disintegrating mill, and the stream pressure of airslide disintegrating mill is 600~8000kPa, and charging rate is
180~200rmin-1, grade frequency is 20~30Hz, and grinding time is 20~30min, obtains Ultramicro-powder, surpasses after ultramicro grinding
Grain size of micropowder is 10~60 μm, and all materials electronic scale between weighing is weighed after crushing；Pretreatment of raw material includes will be golden
Waist grass, walnut kernel, christina loosestrife herb, Wang Anyi, kiss-me, the root of Chinese clematis, hangs pumpkin vine, water chestnut respectively in brine at excrementum pteropi
In impregnated, brine strength 5-10%, cleaning, pull out and dried under rear room temperature.
Step (2) is transmitted to groove profile compound department, workshop temperature the load weighted raw material in workshop is weighed by sterile transferring window
14 degree, humidity 30% are spent, raw material and pure sesame oil dispensing in CH-200 mixing machines, incorporation time is 20-30 minutes, 20 turns/
Point, incorporation time is set by technological requirement, material is released with stainless steel barrel；When mixing, it is passed through nitrogen, protects active ingredient.
Step (3), will mix raw material by sterile transferring window be transmitted to tabletting workshop carry out tabletting, tablet press machine model
ZPW-19B, 3.8 thousand Ns of tablet press machine pressure, loading 5mm, every 1 gram of net content check a net content in every 10 minutes,
Net content is asked to reach between 1.05-1.10 grams；
Step (4), every bottled 60 Chinese medicine composition tablets, seal, have sealed bottle being transmitted to outsourcing entrucking later
Between labelled, case；The bottle labelling that inner packing workshop is transmitted, label print the date of manufacture, post label and are packed into greatly
Case, per 120 bottles of box installed；
Step (5), the qualified storage of product laboratory detection.
Comparative example 1
A kind of Chrysosplenium nudicaule Bunge excrementum pteropi product, includes the material component of following parts by weight：It is 3 parts of Chrysosplenium nudicaule Bunge, 6 parts of walnut kernel, big
4 parts of desmodium, 2 parts of kiss-me, 3 parts of the root of Chinese clematis, hangs 4 parts of pumpkin vine, 1.5 parts of water chestnut, 1 part of pure sesame oil at 2 parts of Wang Anyi.
Above-mentioned Chrysosplenium nudicaule Bunge excrementum pteropi product is tablet, and preparation method includes the following steps：
Step (1), by Chrysosplenium nudicaule Bunge, walnut kernel, christina loosestrife herb, Wang Anyi, kiss-me, the root of Chinese clematis, hang pumpkin vine, water chestnut
After shepherd's purse pretreatment of raw material, crushing is dried at normal temperatures, the said goods examine qualified raw material Chrysosplenium nudicaule Bunge, walnut kernel, great Jin
Money grass, Wang Anyi, kiss-me, the root of Chinese clematis, hang pumpkin vine, water chestnut by technology preparation proportioning crush workshop use air-flow powder
Broken machine carries out ultramicro grinding, and the stream pressure of airslide disintegrating mill is 600~8000kPa, and charging rate is 180~200rmin-1, grade frequency is 20~30Hz, and grinding time is 20~30min, obtains Ultramicro-powder, after ultramicro grinding Ultramicro-powder grain size be 10~
60 μm, all materials electronic scale between weighing is weighed after crushing；Pretreatment of raw material includes by Chrysosplenium nudicaule Bunge, walnut kernel, big
Desmodium, kiss-me, the root of Chinese clematis, hangs pumpkin vine, water chestnut and is impregnated in brine respectively Wang Anyi, and brine strength is
5-10%, cleaning, pulls out and is dried under rear room temperature.
Step (2) is transmitted to groove profile compound department, workshop temperature the load weighted raw material in workshop is weighed by sterile transferring window
14 degree, humidity 30% are spent, raw material and pure sesame oil dispensing in CH-200 mixing machines, incorporation time is 20-30 minutes, 20 turns/
Point, incorporation time is set by technological requirement, material is released with stainless steel barrel；When mixing, it is passed through nitrogen, protects active ingredient.
Step (3), will mix raw material by sterile transferring window be transmitted to tabletting workshop carry out tabletting, tablet press machine model
ZPW-19B, 3.8 thousand Ns of tablet press machine pressure, loading 5mm, every 1 gram of net content check a net content in every 10 minutes,
Net content is asked to reach between 1.05-1.10 grams；
Step (4), every bottled 60 Chinese medicine composition tablets, seal, have sealed bottle being transmitted to outsourcing entrucking later
Between labelled, case；The bottle labelling that inner packing workshop is transmitted, label print the date of manufacture, post label and are packed into greatly
Case, per 120 bottles of box installed；
Step (6), the qualified storage of product laboratory detection.
Comparative example 2
A kind of Chrysosplenium nudicaule Bunge excrementum pteropi product, includes the material component of following parts by weight：It is 4 parts of excrementum pteropi, 6 parts of walnut kernel, big
4 parts of desmodium, 2 parts of kiss-me, 3 parts of the root of Chinese clematis, hangs 4 parts of pumpkin vine, 1.5 parts of water chestnut, 1 part of pure sesame oil at 2 parts of Wang Anyi.
Above-mentioned Chrysosplenium nudicaule Bunge excrementum pteropi product is tablet, and preparation method includes the following steps：
Step (1), by excrementum pteropi, walnut kernel, christina loosestrife herb, kiss-me, the root of Chinese clematis, hang pumpkin vine, water chestnut raw material and locate in advance
After reason, crushing is dried at normal temperatures, the said goods examine qualified raw material excrementum pteropi, walnut kernel, christina loosestrife herb, brave ear
Grass, the root of Chinese clematis, hang pumpkin vine, water chestnut by technology preparation proportioning crush workshop using airslide disintegrating mill carry out ultramicro grinding, gas
The stream pressure for flowing pulverizer is 600~8000kPa, and charging rate is 180~200rmin-1, grade frequency be 20~
30Hz, grinding time are 20~30min, obtain Ultramicro-powder, and Ultramicro-powder grain size is 10~60 μm after ultramicro grinding, property after crushing
Material electronic scale between weighing is weighed；Pretreatment of raw material includes by excrementum pteropi, walnut kernel, christina loosestrife herb, kiss-me, Wheeling
It is celestial, hang pumpkin vine, water chestnut and impregnated in brine respectively, brine strength 5-10%, cleaning is pulled out and is dried under rear room temperature.
Step (2) is transmitted to groove profile compound department, workshop temperature the load weighted raw material in workshop is weighed by sterile transferring window
14 degree, humidity 30% are spent, raw material and pure sesame oil dispensing in CH-200 mixing machines, incorporation time is 20-30 minutes, 20 turns/
Point, incorporation time is set by technological requirement, material is released with stainless steel barrel；When mixing, it is passed through nitrogen, protects active ingredient.
Step (3), will mix raw material by sterile transferring window be transmitted to tabletting workshop carry out tabletting, tablet press machine model
ZPW-19B, 3.8 thousand Ns of tablet press machine pressure, loading 5mm, every 1 gram of net content check a net content in every 10 minutes,
Net content is asked to reach between 1.05-1.10 grams；
Step (4), every bottled 60 Chinese medicine composition tablets, seal, have sealed bottle being transmitted to outsourcing entrucking later
Between labelled, case；The bottle labelling that inner packing workshop is transmitted, label print the date of manufacture, post label and are packed into greatly
Case, per 120 bottles of box installed；
Step (5), the qualified storage of product laboratory detection.
Comparative example 3
Unlike a kind of Chrysosplenium nudicaule Bunge excrementum pteropi product and embodiment 2, include the material component of following parts by weight：Golden waist
3 parts of grass, 6 parts of walnut kernel, 6 parts of christina loosestrife herb, 2 parts of Wang Anyi, 2 parts of kiss-me, 3 parts of the root of Chinese clematis, hangs south at 4 parts of excrementum pteropi
Melon is 4 parts climing, 1.5 parts of water chestnut, 1 part of pure sesame oil.
Comparative example 4
Unlike a kind of Chrysosplenium nudicaule Bunge excrementum pteropi product and embodiment 2, include the material component of following parts by weight：Golden waist
3 parts of grass, 6 parts of walnut kernel, 4 parts of christina loosestrife herb, 0.5 part of Wang Anyi, 2 parts of kiss-me, 3 parts of the root of Chinese clematis, is hung 4 parts of excrementum pteropi
4 parts of pumpkin vine, 1.5 parts of water chestnut, 1 part of pure sesame oil.
(1) animal acute toxicity test is carried out to tablet prepared by the present invention：
Drug：Raw material used in the present invention is commercially available from common Chinese shop, and specification meets national Chinese medicine standard.
Subjects：Small white mouse, weight is in 50g or so, male and female random selection.
Method and result：Small white mouse 10 is taken, it is 24 hours or so hungry, it feeds the application at twice daily by every and implements
Chinese medicine composition prepared by example 2,10 tablets once, continuous to feed after a week, observes 10 days, and mouse activity is normal, non-toxic reaction, nothing
Death shows the tablet of the present invention without acute toxicity, clinical medicine dose safety.
(2) long-term toxicity test for animals is carried out to tablet prepared by the present invention：
Experimental animal：Big white mouse, weight is in 120-130g, male and female random selection.
Method and result：Big white mouse 20 is taken, is divided into 2 groups, every group 10, wherein the 1st group is used as administration group, often by every
It feeds for it 2 times, 10 tablets once, and the 2nd group of diet as a control group, continuous 90 days, surveys weight, 24 after last time is administered
Hour sacrificed by decapitation surveys blood, routine urinalysis, liver function, renal function, the internal organ such as coring, kidney, the variation of tissues observed form, observation
The effect of dosage, observation diet, movable variation, experiments have shown that administration group is compared with the control group without significant changes, it is non-toxic
Reaction, is a kind of safe drugs.
Chinese medicine composition prepared by the application has carried out clinical test, and clinical criteria is as follows：
The diagnosis of cholecystolithiasis is to have right upper quadrant of the abdomen pain as usual according to morbidity history, and radiated to right shoulder, companion first
There are the symptoms such as fever to make tentative diagnosis, is then made a definite diagnosis by ultrasound diagnosis, B ultrasound can clearly display cholecystolithiasis
This efficacy assessment standard is reference《New Chinese medicine guideline of clinical investigations》It formulates, specific standards are as follows:
(1) it fully recovers：Clinical symptom and sign disappears, and liver function is normal, and courage type-B ultrasonic checks normal, B ultrasound check calculus emptying；
(2) effective：Clinical symptom and sign disappears, and liver function is normal, and courage type-B ultrasonic checks normally, and calculus, B are discharged in stool
The stone that comes to an end is onlapped to substantially reduce；
(3) effectively：Clinical symptom and sign disappears, and total bilirubin increases, and courage type-B ultrasonic inspection prompts courage intracystic stones to exist；
(4) invalid：Clinical symptom and sign and auxiliary examination are showed no improvement.
Treatment results：In order to verify clinical efficacy, the application has carried out clinic trial, under the premise of the principle of voluntariness, with
Machine chooses wherein 210 patients, and is randomly divided into seven groups, every group of 30 people.
Therapy：Every group is taken Chrysosplenium nudicaule Bunge excrementum pteropi product sheet prepared by the present embodiment 1-3 and comparative example 1-4 respectively
Agent twice daily ten every time, takes in the morning and evening, and two weeks as a treatment course, totally three courses for the treatment of.
Specific treatment results are referring to table 1.
It takes and is counted after terminating three courses for the treatment of, situation see the table below shown in 1, illustrate the application Chrysosplenium nudicaule Bunge excrementum pteropi product
Have the function of significantly treating gall stone.
1 curative effect situation of table
By above-mentioned data in table 1 it is found that after the Chinese medicine composition for taking the present invention, effective percentage maintains 90%-
96.67%, wherein cure rate maintains 83.33%-90%.Comparative example 1- comparative examples 4 due to ingredient in formula or content into
Adjustment is gone, effective percentage only maintains 20%-40%, and wherein cure rate is only up to 20%.
Data above further illustrates that the present invention has gall stone apparent therapeutic effect, after being taken according to the course for the treatment of,
Gall stone can be treated, cure rate is high, in a short time without recurrence.In addition the raw material type of the application is few, is pure natural raw material, safety
Reliably, it has no toxic side effect, selected medicinal material compatibility is suitable, meets traditional Chinese medicine and pharmacy and modern medical theory, according to monarch
Combination principle reaches unexpected therapeutic effect for the treatment of gall stone, and using convenient source, convenient for materials, price is low
Honest and clean, preparation method is simple.
It should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；Although
Present invention has been described in detail with reference to the aforementioned embodiments, it will be understood by those of ordinary skill in the art that：It is still
Either which part or all technical features can be carried out so that technical scheme described in the above embodiments is modified
Equivalent replacement；And these modifications or replacements, it does not separate the essence of the corresponding technical solution various embodiments of the present invention technical side
The range of case.
Claims (8)
1. a kind of Chrysosplenium nudicaule Bunge excrementum pteropi product, is characterized in that：Include the material component of following parts by weight：2-4 parts of Chrysosplenium nudicaule Bunge, five spirits
3-5 parts of fat, 4-8 parts of walnut kernel, 2-5 parts of christina loosestrife herb, 1-3 parts of Wang Anyi, 1.5-3 parts of kiss-me, 2-4 parts of the root of Chinese clematis,
Hang 3-6 parts of pumpkin vine, 1-2 parts of water chestnut, 0.5-2 parts of pure sesame oil.
2. a kind of Chrysosplenium nudicaule Bunge excrementum pteropi product as described in claim 1, it is characterised in that：Include the raw material group of following parts by weight
Part：2 parts of Chrysosplenium nudicaule Bunge, 3 parts of excrementum pteropi, 4 parts of walnut kernel, 2 parts of christina loosestrife herb, 1 part of Wang Anyi, 1.5 parts of kiss-me, the root of Chinese clematis
2 parts, hang 3 parts of pumpkin vine, 1 part of water chestnut, 0.5 part of pure sesame oil.
3. a kind of Chrysosplenium nudicaule Bunge excrementum pteropi product as described in claim 1, it is characterised in that：Include the raw material group of following parts by weight
Part：3 parts of Chrysosplenium nudicaule Bunge, 4 parts of excrementum pteropi, 6 parts of walnut kernel, 4 parts of christina loosestrife herb, 2 parts of Wang Anyi, 2 parts of kiss-me, the root of Chinese clematis 3
Part hangs 4 parts of pumpkin vine, 1.5 parts of water chestnut, 1 part of pure sesame oil.
4. a kind of Chrysosplenium nudicaule Bunge excrementum pteropi product as described in claim 1, it is characterised in that：Include the raw material group of following parts by weight
Part：4 parts of Chrysosplenium nudicaule Bunge, 5 parts of excrementum pteropi, 8 parts of walnut kernel, 5 parts of christina loosestrife herb, 3 parts of Wang Anyi, 3 parts of kiss-me, the root of Chinese clematis 4
Part hangs 6 parts of pumpkin vine, 2 parts of water chestnut, 2 parts of pure sesame oil.
5. a kind of Chrysosplenium nudicaule Bunge excrementum pteropi product as described in claim 1, it is characterised in that：The Chrysosplenium nudicaule Bunge excrementum pteropi product
Dosage form is any one in powder, pulvis, tablet, granule, decoction, oral solution, honey ointment body, honeydew, beverage or tea bag preparation
Kind.
6. the preparation method of the Chrysosplenium nudicaule Bunge excrementum pteropi product as described in any one of claim 1-5, Chrysosplenium nudicaule Bunge excrementum pteropi product
For tablet, it is characterised in that：Preparation method includes the following steps：
(1) by Chrysosplenium nudicaule Bunge, excrementum pteropi, walnut kernel, christina loosestrife herb, Wang Anyi, kiss-me, the root of Chinese clematis, hang pumpkin vine, water chestnut
It is weighed after crushing workshop and crushing according to the ratio after shepherd's purse feedstock processing；
(2) mixes load weighted raw material and pure sesame oil in step (1) in mixing machine, setting incorporation time, rotating speed,
Raw material is released after mixing；
(3) raw material mixed is carried out tabletting by using tablet press machine；
(4) it is packed after tablettings, after the completion of packaging, the qualified storage of product laboratory detection.
7. a kind of preparation method of Chrysosplenium nudicaule Bunge excrementum pteropi product as claimed in claim 6, it is characterised in that：The step (1)
Needed before sieving to Chrysosplenium nudicaule Bunge, excrementum pteropi, walnut kernel, christina loosestrife herb, Wang Anyi, kiss-me, the root of Chinese clematis, hang pumpkin vine,
Water chestnut is tested, and is crushing workshop ultramicro grinding according to the ratio after the assay was approved.
8. a kind of preparation method of Chrysosplenium nudicaule Bunge excrementum pteropi product as claimed in claim 6, it is characterised in that：The step (1)
It is ultramicro grinding to crush, and Ultramicro-powder grain size is 10~60 μm after ultramicro grinding.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988904A (en) * | 2012-12-20 | 2013-03-27 | 周秀尧 | Drug for removing gall stone |
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2018
- 2018-06-20 CN CN201810639548.9A patent/CN108743766A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988904A (en) * | 2012-12-20 | 2013-03-27 | 周秀尧 | Drug for removing gall stone |
Non-Patent Citations (4)
| Title |
|---|
| 安言 编著: "《食物相克与相宜大全集》", 31 May 2011, 中国华侨出版社 * |
| 朵德祥 等: "十五味尔赛斗丸治疗胆结石的临床研究", 《中国临床药理学杂志》 * |
| 行者无忌…: "治疗胆结石的偏方", 《360个人图书馆》 * |
| 陈绍成 等 主编: "《长江三峡天然药用植物志》", 31 August 2016, 重庆大学出版社 * |
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