CN108743669A - Chinese medicine composition and its preparation method and application for treating goat - Google Patents
Chinese medicine composition and its preparation method and application for treating goat Download PDFInfo
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Abstract
The present invention relates to a kind of for treating the Chinese medicine composition and its preparation method and application of goat, wherein the bulk pharmaceutical chemicals of the Chinese medicine composition include：Lucidum spore powder, Poria cocos, plantago seed, celery seed and sunflower disk.The Chinese medicine composition, the characteristics of for goat, from tonifying the liver and kidney, expelling wind and clearing away cold, dehumidifying, dredging collateral set out, and the Chinese medicine of a variety of integration of drinking and medicinal herbs with anti-trioxypurine are chosen, according to the theory of Chinese medicine " monarch ", it is proposed effective pharmaceutical composition, synergistic function is played, uric acid synthesis is inhibited and promotes uric acid excretion, it is horizontal effectively to reduce uric acid content, simultaneously, hepatic and renal function can be improved to a certain extent, to promoting goat rehabilitation efficacy notable, and had no toxic and side effect to human body.
Description
Technical field
The present invention relates to technical field of Chinese medicine, more particularly to a kind of Chinese medicine composition for treating goat and its
Preparation method and application.
Background technology
Gout is the metabolic disease that long-term disorders of purine metabolism causes uric acid to increase.Purine is that there are a kind of objects in human body
Matter plays important regulative to energy supply, Metabolism regulation etc..If body fails to be discharged by purine metabolism or from kidney
In vitro, these substances can ultimately form uric acid, and accumulate internal, formation uric acid crystal, i.e. tophus with crystalline solid.If there is inducement
Cause the uric acid crystal for being deposited on soft tissue to disengage, inflammation can be caused.Patient with gout has native endowment insufficient and the diet day after tomorrow more
History is not saved, including overfeeding delicious food savoury or greedy slurry etc. of drinking, chronic dietary do not save then impairing the spleen and stomach, transporting and transforming function of the spleen and stomach, which loses, is good for, and causes
It is raw in the turbid pathogenic factors such as phlegm wet, damp and hot, block channels and collaterals, numbness choke blood causes gout.Ming Dynasty's name doctor's Gong Tingxian exists《Wanbing Huichun, Curative Measures for All Diseases》Middle finger
Go out：" all gouts limbs pain person, pain belong to fire, and the category that swells is wet ... so the people of fat meat and fine grain, more foods, which are decocted, to be fried, processs Bo, wine meat, and hot object steams
Internal organs, so suffering from gout, malignant sore ulcer person is most." therefore think that gout is caused by overfeeding greasy and surfeit flavour, the damp and hot resistance numbness of interior life.Zhu
Good spring professor thinks that its main pathogenesis is endogenous damp formation, the stagnant passages through which vital energy circulates of the stasis of blood.LU Zhi-zheng professor thinks that gout pathological characteristic is：" source it
Middle coke, burnt under flow resistance, disease is in lower limb ", " arising from taste, finally liver kidney ".Professor Shang Xianmin thinks that turbid damp evil phlegm is to lead to gout
Etiological, qi and blood passages through which vital energy circulates retardance be cause gout break out the important pathogenesis, because it is moist stick greasy difficulty remove, be most easily reluctant to leave, thus this
Disease has the characteristics of recurrent exerbation, the course of disease are long, are difficult to effect a radical cure.
According to statistics, for China's Patients with Hyperuricemia close to 1.7 hundred million, incidence has reached 13.3%, and lasting rising at present,
It has become " the 4th is high " after hypertension, hyperglycemia, hyperlipidemia.Meanwhile gout patients have also been more than 78,000,000.National wind
Diseases caused by dampness data center statistical data shows, by 2 months 2016, China's patient with gout average age 48.28 years old, male to female ratio was
15：1, and age of onset gradually tends to rejuvenation.The disease is since hypersaturated state is presented in uric acid in blood, in addition to bone, joint
It causes directly damage outer, can also be deposited on kidney and cause nephropathy, to endangering there are larger danger for health, receive
The extensive concern of medical field.
Modern medicine mostly uses colchicin, probenecid, allopurinol etc. to mitigate symptom, reduces blood uric acid, but this
Class Western medicine will produce gastrointestinal reaction, influence hepatic and renal function, big to human body side effect.Therefore, western medical treatment gout receives one
Definite limitation.In recent years, the Chinese medicine treatment of gout has become an important means, but the research of Chinese medicine treatment gout is not yet
Obtain greater advance.
Invention content
Based on this, it is necessary to for Western medicine problem big to human body side effect and palliative, provide a kind of for controlling
Treat the Chinese medicine composition of goat.
A kind of Chinese medicine composition for treating goat, the bulk pharmaceutical chemicals of the Chinese medicine composition include：Reishi sporule
Powder, Poria cocos, plantago seed, celery seed and sunflower disk.
Lucidum spore powder, for the monarch drug in a prescription of the present invention.Ganoderma lucidum (Ganoderma lucidum), as drug first recorded in《The legendary god of farming
Book on Chinese herbal medicine warp》, reinforcement can be moistened and strengthened, strengthen the body resistance to consolidate the constitution, promote longevity, had and inhibited tumour, improve immunity, is hypoglycemic and anti-oxidant
Equal multi-efficiencies.Ganoderma lucidum belongs to a kind of medicinal fungi plant of Basidiomycetes Polyporaceae Ganoderma, and Reishi sporule is ganoderma lucidum in life
The reproduction cell ejected from cap when long ripe, also referred to as basidiospore.Rich in ganoderma lucidum polysaccharide, nucleotide in lucidum spore powder
Etc. can boost metabolism, the purine metabolism in human body is improved, is combined with internal uric acid and it is promoted to excrete；Meanwhile
Also analgesic acts on.Lucidum spore powder is also micro- containing abundant ganodenic acid, adenosine, amino acid and organic germanium etc., tool
There are " anti-oxidant " and " blood-cleaning detoxifying ", has certain protective role to organs such as liver, kidneys, immune system can also be enhanced
Function.
Poria cocos, for the ministerial drug of the present invention.Poria cocos Poria cocos (Schw.) Wolf belongs to On Polyporaceae, is commonly called as cloud
Siberian cocklebur, Song Ling, Fu spirit, ancients' Poria cocos is referred to as " god's medicine when four ", by it and various compatibility of drugs, regardless of cold, temperature, wind, wet all diseases, all
Its unique effects can be played.Poria cocos is sweet in flavor, light, mild-natured, enters the heart, lung, the spleen channel, has clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative
Function.Modern medicine study shows Poria cocos, and to gout, the treatment works well, and Poria cocos Li Shui is by strong fortune spleen and lung function
Reach, it is different from other Chinese medicines of direct Li Shui；Poria cocos can also enhance body's immunity.
Plantago seed and celery seed, for the adjutant of the present invention.Plantago seed is plantago plant Chinese herbaceous peony (Plantago
Asiatica L.) mature seed there is reducing fever and causing diuresis for civil herbal medicine the most popular, excreting dampness antidiarrheal, improving eyesight, eliminating the phlegm it
Effect.Inhibit uric acid synthesis studies have shown that plantago seed has, reduce uric acid level and treatment pain wind action.
Celery seed is the mature seed of samphire celery (ApiumgrauensL.var.dulcedc), containing rich
The minerals such as rich cineol, apiolin, umbrella flower lactone, leukotrienes, flavones and calcium, magnesium, zinc.Celery seed is arranged with uricosuric
The effect for letting out, improving renal function, hyperuricemia mice serum urine can be significantly reduced by being embodied in the apiolin that it contains
Acid and urine uric acid level, to protect renal function.
Sunflower disk makes medicine for the present invention.Sunflower disk is feverfew sunflower (Helianthus annuus L.)
Floral disc has heat-clearing, anti-inflammation detumescence, anti-trioxypurine, dissolving Monosodium urate, analgesic wherein containing abundant flavones, alkaloid and polysaccharide
Effect.Some researches show that it is multiple can to specifically bind uric acid formation sunflower alkalinuria acid from the alkaloid in sunflower disk extract
Object is closed, uric acid is eliminated；Sunflower disk flavones is a kind of very strong antioxidant, can effectively remove internal oxygen radical, is prevented
The oxidation of nucleic acid is played the role of reducing purine content, while can also reduce capillary fragility, increases permeability to mitigate kidney
Dirty red blood cell pressure, through more uric acid.
Above-mentioned Chinese medicine composition, the characteristics of for goat, from tonifying the liver and kidney, expelling wind and clearing away cold, dehumidifying, dredging collateral set out, choosing
The Chinese medicine for taking a variety of integration of drinking and medicinal herbs with anti-trioxypurine proposes effective medicine group according to the theory of Chinese medicine " monarch "
It closes, plays synergistic function, inhibit uric acid synthesis and promote uric acid excretion, it is horizontal effectively to reduce uric acid content, meanwhile, it can be
Improve hepatic and renal function to a certain extent, to promoting goat rehabilitation efficacy notable, and has no toxic and side effect to human body.
The Chinese medicine composition is mainly grouped as by the group of following parts by weight in one of the embodiments,：Broken wall spirit
15~25 parts of Ganoderma lucidum spore powder, 10~20 parts of tuckahoe extracts, 20~30 parts of Chinese herbaceous peony seed extract, 20~30 parts of Celeryseed extract
With 10~20 parts of sunflower disk extract.
In one of the embodiments, the ganoderma spove powder be 18~22 parts, the tuckahoe extracts be 12~
15 parts, the Chinese herbaceous peony seed extract is 22~26 parts, and the Celeryseed extract is 22~28 parts, and the sunflower disk extract is
13~16 parts.
Further, the ganoderma spove powder is 20 parts, and the tuckahoe extracts are 15 parts, the plantago seed extraction
Object is 25 parts, and the Celeryseed extract is 25 parts, and the sunflower disk extract is 15 parts.
The sporoderm-broken rate of the ganoderma spove powder is more than 95% in one of the embodiments,.
The ganoderma spove powder is Reishi sporule through the Ultramicro-powder obtained by broken wall, institute in one of the embodiments,
The broken wall step for stating ganoderma spove powder includes：After carrying out Microwave Pretreatment to Reishi sporule under vacuum, liquid is carried out
Nitrogen deep cooling freezing processing freezes to the temperature of the Reishi sporule and is less than or equal to -30 DEG C, then carries out air-flow crushing.
Reishi sporule have double-layer cell wall, be mainly chitin, cause its tough and tensile cell wall, acid and alkali-resistance, it is resistance to enzymolysis,
The properties such as anti-digestion, pressure-resistant heat resistanceheat resistant, hinder human body digesting and assimilating and utilizing to effective component of ganoderma lucidum spore powder.It first passes through micro-
Wave pretreatment makes the chitin fiber of Reishi sporule wall be broken, and improves the brittleness of Reishi sporule wall, and reduce in lucidum spore powder
The content of water, then liquid nitrogen deep freezing processing is carried out, the brittleness of Reishi sporule wall is further increased, is carried out to lucidum spore powder
When air-flow crushing, water content is lower, and the brittle degree of conidial cell wall is higher, easier broken wall, and shell-broken effect is better.
The tuckahoe extracts, Chinese herbaceous peony seed extract, Celeryseed extract and sunflower disk carry in one of the embodiments,
Take object be respectively Poria cocos, plantago seed, celery seed and sunflower disk after crushed, with volumetric concentration be 65%~75% ethyl alcohol it is water-soluble
Liquid extracts 40h~50h, and filtering obtains filtrate, concentrates the medicinal extract of gained after filtrate, and the relative density of the medicinal extract is 1.1~
1.15。
Another object of the present invention is to provide a kind of preparation method for treating the Chinese medicine composition of goat, including with
Lower step：
Reishi sporule is taken, after carrying out Microwave Pretreatment to Reishi sporule under vacuum, is carried out at liquid nitrogen deep freezing
Reason freezes to the temperature of the Reishi sporule and is less than or equal to -30 DEG C, then carries out air-flow crushing, obtain ganoderma spove powder；
After respectively crushing Poria cocos, plantago seed, celery seed and sunflower disk, it is 65%~75% second to use volumetric concentration respectively
Alcohol solution extracts 40h~50h, and filtering obtains filtrate, obtains the medicinal extract that relative density is 1.1~1.15 after concentrating filtrate, that is, divides
Tuckahoe extracts, Chinese herbaceous peony seed extract, Celeryseed extract and sunflower disk extract are not obtained；
Take 15~25 parts of ganoderma spove powders, 10~20 parts of tuckahoe extracts, 20~30 parts of Chinese herbaceous peonies
Seed extract, 20~30 parts of Celeryseed extracts and 10~20 parts of sunflower disk extracts, each component is mixed, and is obtained described
Chinese medicine composition.
The temperature of the microwave treatment is 30 DEG C~40 DEG C in one of the embodiments, and the time is 10min~20min.
In this way, to Reishi sporule progress microwave treatment it is possible to prevente effectively from the oxygen of Reishi sporule under vacuum low-temperature environment
Change, reduces influence of the oxygen in air to nutriment in Reishi sporule, and low temperature environment effectively can overcome microwave to spirit
The heat damage that the heat effect of Ganoderma lucidum spore generates can fully maintain the ganoderma lucidum polysaccharide contained in Reishi sporule powder raw material, three
The effect of active ingredients high-content such as terpene, organic germanium, raising product.
In one of the embodiments, the tuckahoe extracts be poria cocos sclerotium after crushed, with volumetric concentration be 65%
~75% ethanol water extracts the medicinal extract of gained after 40h~50h, filtering, filtrate concentration, and the relative density of the medicinal extract is
1.1~1.15.
Further, the mass volume ratio of the poria cocos sclerotium and the ethanol water is 1g：(15~20) mL.
The mass volume ratio of the plantago seed and the ethanol water is 1g in one of the embodiments,：(15~
20)mL。
The mass volume ratio of the celery seed and the ethanol water is 1g in one of the embodiments,：(10~
20)mL。
The mass volume ratio of the sunflower disk and the ethanol water is 1g in one of the embodiments,：(10~
20)mL。
In one of the embodiments, the preparation method further include above-mentioned Chinese medicine composition is dried, powder processed
Step.
Further, the step of the drying is that the Chinese medicine composition is carried out microwave drying under vacuum environment.Such as
This, play the role of uniformly, rapid draing while can also sterilize.Water is the strongly absorbing medium of microwave, and microwave can allow microorganism
In hydrone formed galvanic couple polarity and with electric field change and high speed transport, cause membrane structure to rupture, hydrogen between cellular elements
Key destroys, to have the function that sterilization.
Specifically, vacuum microwave drying case can be used, processing is dried.
Another object of the present invention is to provide a kind of above-mentioned Chinese medicine composition in preparing the drug for controlling goat
Using.
Another object of the present invention is to provide a kind of pharmaceutical preparation, is with the above-mentioned Chinese traditional medicine composition for treating goat
Object is active constituent.
Further, the pharmaceutical preparation can be with the Chinese medicine composition and medically acceptable pharmaceutic adjuvant,
The various dosage forms for being suitable for clinical application, including but not limited to capsule, granule, piece are made by the conventional method of pharmaceutical preparation
The dosage forms such as agent, oral solution.
The invention has the advantages that：
1), the present invention chooses the Chinese medicine of five tastes integration of drinking and medicinal herbs, it then follows the principles of formulating prescriptions of Chinese medicine " monarch ", with ganoderma lucidum
Conidia powder is monarch drug in a prescription, Poria cocos is ministerial drug, plantago seed celery seed is adjutant, sunflower disk is to make medicine, and reasonable formula, all medicine phases are closed, energy
It enough tonifies the liver and kidney, expelling wind and clearing away cold, dehumidifying, dredging collateral inhibit uric acid synthesis and promote uric acid excretion, effectively reduce uric acid content water
It is flat, meanwhile, hepatic and renal function can be improved to a certain extent, to promoting goat rehabilitation efficacy notable, had to the nontoxic pair of human body
The features such as acting on, is stable and controllable for quality, has a good application prospect in goat rehabilitation field.
2), Chinese medicine composition of the present invention selects ganoderma spove powder, tuckahoe extracts, Chinese herbaceous peony seed extract, celery seed
Extract and sunflower disk extract are that raw material carries out prescription, more convenient to use to which taking dose is small.
Specific implementation mode
To facilitate the understanding of the present invention, below will to invention is more fully described, and give the present invention compared with
Good embodiment.But the present invention can realize in many different forms, however it is not limited to embodiment described herein.Phase
Instead, purpose of providing these embodiments is makes the disclosure of the present invention more thorough and comprehensive.
Unless otherwise defined, all of technologies and scientific terms used here by the article and belong to the technical field of the present invention
The normally understood meaning of technical staff is identical.Used term is intended merely to description tool in the description of the invention herein
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more phases
Any and all combinations of the Listed Items of pass.
A kind of Chinese medicine composition for treating goat of embodiment 1
1, the formula of Chinese medicine composition：15~25 parts of ganoderma spove powder, 10~20 parts of tuckahoe extracts, plantago seed carry
Take 20~30 parts of object, 20~30 parts of Celeryseed extract, 10~20 parts of sunflower disk extract.
2, each component raw material
1), ganoderma spove powder
Ganoderma spove powder is the drying spore of On Polyporaceae red sesame or purple sesame through the Ultramicro-powder obtained by broken wall, is pressed
NY/T1677-2008《The measurement of ganoderma spove powder sporoderm-broken rate》, it is desirable that broken rate must not be less than 95%, can also pass through
Commercially available purchase can also be prepared by the following method and obtain：
Reishi sporule is taken, pretreatment 15min is carried out to Reishi sporule using microwave under 30 DEG C~40 DEG C of cryogenic conditions,
Liquid nitrogen deep freezing processing is carried out to Reishi sporule using liquid nitrogen deep instant freezer, is frozen to donor center temperature to -35 DEG C, then
Supersonic airstream broken wall is carried out at -10 DEG C using supersonic jet mill, crushing mesh number is 800 mesh, obtains wall-broken ganoderma spore
Powder, sporoderm-broken rate reach 99.5%.
2), tuckahoe extracts
Tuckahoe extracts are extract made of poria cocos sclerotium warp adds, can be by commercially available purchase, also can be by with lower section
Method is prepared：
Dry poria cocos sclerotium is taken, coarse powder (30 mesh) is ground into, is 1g by the mass volume ratio of Poria cocos coarse powder and ethyl alcohol：
18mL, with the alcohol solvent of 70vol%, after impregnating Poria cocos coarse powder 48h, filtering collects filtrate, ethyl alcohol is recovered under reduced pressure and is concentrated into
Relative density is the medicinal extract of 1.1~1.15 (65 DEG C), obtains tuckahoe extracts.
3), Chinese herbaceous peony seed extract
Chinese herbaceous peony seed extract is Asiatic plantain mature seed warp plus manufactured extract, can also be led to by commercially available purchase
Following methods are crossed to be prepared：
Dry plantago seed is taken, coarse powder (30 mesh) is ground into, is 1g by the mass volume ratio of plantago seed coarse powder and ethyl alcohol：
15mL, with the alcohol solvent of 70vol%, after impregnating plantago seed coarse powder 48h, filtering collects filtrate, ethyl alcohol is recovered under reduced pressure and concentrates
To the medicinal extract that relative density is 1.1~1.15 (65 DEG C), Chinese herbaceous peony seed extract is obtained.
4), Celeryseed extract
Celeryseed extract is extract made of celery seed warp adds, can be by commercially available purchase, also can be by with lower section
Method is prepared：
Celery seed powder is broken into coarse powder (30 mesh), is 1g by the mass volume ratio of celery seed coarse powder and ethyl alcohol：15mL is used
After the alcohol dipping celery seed coarse powder 48h of 70vol%, filtrate is collected in filtering, ethyl alcohol is recovered under reduced pressure and is concentrated into relative density is
The medicinal extract of 1.1~1.15 (65 DEG C), obtains Celeryseed extract, extract yield 7.5%.
5), sunflower disk extract
Sunflower disk extract is extract made of sunflower disk is processed, can be by commercially available purchase, also can be by following
Method is prepared：
Dry sunflower disk is ground into coarse powder (30 mesh), is 1g by the mass volume ratio of sunflower disk coarse powder and ethyl alcohol：
10mL, after the alcohol dipping sunflower disk coarse powder 48h of 70vol%, filtering collects filtrate, ethyl alcohol is recovered under reduced pressure and is concentrated into phase
To the medicinal extract that density is 1.1~1.15 (65 DEG C), sunflower disk extract is obtained.
Embodiment 2 is used to treat the electuary of goat
1500 grams of 2000 grams of ganoderma spove powder, tuckahoe extracts, the plantago seed weighed respectively in above-described embodiment 1 carries
Take 2500 grams of object, 2500 grams of Celeryseed extract, 1500 grams of sunflower disk extract.
The mixture of above-mentioned four kinds of extracts and ganoderma spove powder is placed in vacuum microwave drying case, it is dry in 40 DEG C
Dry 30min, then powder processed, is processed into electuary, per parcel 3g.
Embodiment 3
Embodiment 3 is substantially the same manner as Example 2, the difference is that：Ganoderma spove powder is 220 grams, Poria cocos extracts
Object is 120 grams, Chinese herbaceous peony seed extract is 250 grams, Celeryseed extract is 280 grams, sunflower disk extract is 130 grams.
Embodiment 4
Embodiment 4 is substantially the same manner as Example 2, the difference is that：Ganoderma spove powder is 180 grams, Poria cocos extracts
Object is 150 grams, Chinese herbaceous peony seed extract is 260 grams, Celeryseed extract is 250 grams, sunflower disk extract is 160 grams.
Embodiment 5
Embodiment 5 is substantially the same manner as Example 2, the difference is that：Ganoderma spove powder is 250 grams, Poria cocos extracts
Object is 100 grams, Chinese herbaceous peony seed extract is 200 grams, Celeryseed extract is 300 grams, sunflower disk extract is 150 grams.
Comparative example 1
Comparative example 1 is substantially the same manner as Example 2, the difference is that：Ganoderma spove powder is 200 grams, Poria cocos extracts
Object is 150 grams, Chinese herbaceous peony seed extract is 250 grams, sunflower disk extract is 150 grams.
Comparative example 2
Comparative example 2 is substantially the same manner as Example 2, the difference is that：Ganoderma spove powder is 200 grams, Poria cocos extracts
Object is 150 grams, Celeryseed extract is 250 grams, sunflower disk extract is 150 grams.
Comparative example 3
Comparative example 3 is substantially the same manner as Example 2, the difference is that：Ganoderma spove powder is 200 grams, Poria cocos extracts
Object is 150 grams, Chinese herbaceous peony seed extract is 250 grams, Celeryseed extract is 250 grams.
Comparative example 4
Comparative example 4 is substantially the same manner as Example 2, the difference is that：Tuckahoe extracts are 150 grams, Chinese herbaceous peony seed extract
For 250 grams, Celeryseed extract be 250 grams, sunflower disk extract is 150 grams.
Drop blood of the Chinese medicine composition of 6 Application Example 2~5 of embodiment and comparative example 1~4 to Oteracil Potassium model mice
Uric acid is tested
Experiment material：80 Kunming mouses, male, weight 20g ± 2g are randomly divided into 8 groups, every group 10：Model group,
Electuary group (the 200mg/ of Normal group, allopurinol positive controls (5mg/kg), embodiment 2~5 and comparative example 1~4
kg)。
Experimental method：In addition to Normal group, remaining mouse mainline Oteracil Potassium, after dosage 250mg/kg, 1h,
Each medication group mouse distinguishes gastric infusion 1 time daily, and normal group and model group are with isometric physiological saline gavage, continuous 7d.It gives
Medicine 6d takes 5 mouse to be placed in metabolic cage after 1h is administered, and after adapting to 1d, urine for 24 hours is collected in administration 7d.Urine from
Heart 10min takes supernatant, and it is horizontal to measure urine creatinine for 24 hours.1h after the last administration, each group mouse take blood in eyeball veniplex,
3000r/min centrifuges 10min, takes serum, measures each group mouse blood uric acid, urine uric acid, as a result see the table below 1.
Table 1
As a result：
From, as can be seen that after alloxan inducing mouse goat, mouse liver hepatic glycogen synthesis capability is serious in upper table 1
Impaired, blood sugar concentration is significantly raised.Allopurinol positive controls, embodiment 2~5 and 1~4 electuary group of comparative example and model
Group compares, and can reduce urine uric acid and serum uric acid level to varying degrees and improve urine flesh liver discharge capacity.But implement
In the electuary for the Chinese medicine composition that 1~4 above-mentioned five kind of raw material of example 2~5 and comparative example combines formation in varing proportions, with embodiment
2 effect is optimal.Model group is compared, although 1~4 electuary group of comparative example can reduce uric acid level to a certain extent, effect
Fruit unobvious；Embodiment 2~5 can be substantially reduced uric acid level, and 2 electuary group of embodiment and the significant difference of model control group
It is different, blood uric acid and urine uric acid concentration are can significantly reduce, and to promoting urine liver acid anhydride discharge capacity effect apparent, illustrate implementation of the present invention
2 product of example can protect mouse kidney function, reduce blood uric acid and urine uric acid concentration.
The clinical effectiveness that embodiment 7 carries out the Chinese medicine composition of embodiment 2 goat treatment is verified
Present inventor began one's study from 2015, and formula has constantly been improved since 3 years, did upper 216 formulas
Experiment is improved, the product for having several goat edible for patients excessively of the invention, wherein gout patient on the books 31, wherein man
26, female 5,40 years old 2 below, 19 of 40 or more years old, 6 of 50 years old or more, 4 of 60 or more years old, total effective rate
Reach 89.3%, obvious effective rate reaches 69.1%, and after the drug of the postoperative edible present invention, rehabilitation rate is up to 53.2%, 6 after 6 months
Rehabilitation rate reaches 78.6.% up to rehabilitation rate after 69.6%, 9 month after month, and rehabilitation rate is up to 86.8% after 12 months.
2 product instructions of taking of embodiment：It takes in the morning and evening daily, 3 grams every time, warm water is taken after mixing it with water, and one week is a treatment
Journey, general 3 to 4 courses can reach conditioning rehabilitation efficacy, and high purine food is not fed or fed less in during which few activity, abstinence from alcohol；
Potential gout patient suggests the product of the long-term consumption present invention, every night it is edible one time 3 grams, prevent gout pathogenetic bright
Effective fruit.
It is as follows now to take passages three patient's cases：
, 53 years old, there is finger, toes swollen joint, night sharp ache, before half a year, the right hand refers to pass in five years ago in Peng, man
Save it is stiff become larger, hospital admission check blood uric acid be up to 918 μm of ol/L, be diagnosed as " gout ".Take allopurinol, rosickyite acid
Deng the state of an illness is improved, but uncomfortable is cut out because having a stomachache.4 courses for the treatment of of product for taking the embodiment of the present invention 2 later, face
Bed gout symptom all disappears, and freely, detection blood uric acid is down to normal range (NR) to joint motion.
There is arthralgia in 2014, always non-medication in Luo, female 51 years old, and it is 356 that Uric Acid Content is detected at the beginning of 2017
μm ol/L takes 3 courses for the treatment of of product of the embodiment of the present invention 2, and clinical gout symptom all disappears, joint motion freely, detection
Blood uric acid is down to 204 μm of ol/L.
Dai, man, 56 years old, gout had tophus, and joint has deformed than more serious, and sole thumb is long
Go out tophus, moves two operations, but or so half a year grows tophus again excessively.6 monthly tests in 2017 have a blood test uric acid content as 543 μ
Mol/L, takes the product of the embodiment of the present invention 2, and after 4 courses for the treatment of, clinical symptoms improve, and joint motion is flexible, blood uric acid detection
Content is 401.5 μm of ol/L, normal.
Each technical characteristic of embodiment described above can be combined arbitrarily, to keep description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of for treating the Chinese medicine composition of goat, which is characterized in that the bulk pharmaceutical chemicals of the Chinese medicine composition include：Spirit
Ganoderma lucidum spore powder, Poria cocos, plantago seed, celery seed and sunflower disk.
2. Chinese medicine composition according to claim 1, which is characterized in that the Chinese medicine composition is mainly by following parts by weight
Several groups are grouped as：
3. Chinese medicine composition according to claim 2, which is characterized in that by weight, the ganoderma spove powder
It it is 18~22 parts, the tuckahoe extracts are 12~15 parts, and the Chinese herbaceous peony seed extract is 22~26 parts, the celery seed extraction
Object is 22~28 parts, and the sunflower disk extract is 13~16 parts.
4. Chinese medicine composition according to claim 3, which is characterized in that by weight, the ganoderma spove powder
It it is 20 parts, the tuckahoe extracts are 15 parts, and the Chinese herbaceous peony seed extract is 25 parts, and the Celeryseed extract is 25 parts, institute
It is 15 parts to state sunflower disk extract.
5. according to any Chinese medicine composition of claim 2~4, which is characterized in that the ganoderma spove powder is spirit
Through the Ultramicro-powder obtained by broken wall, the step of broken wall includes Ganoderma lucidum spore：The Reishi sporule is carried out under vacuum micro-
Wave pretreatment after, carry out liquid nitrogen deep freezing processing, freeze to the Reishi sporule temperature be less than or equal to -30 DEG C, then into
Row air-flow crushing.
6. according to any Chinese medicine composition of claim 2~4, which is characterized in that the tuckahoe extracts, plantago seed carry
Take object, Celeryseed extract and sunflower disk extract be respectively Poria cocos, plantago seed, celery seed and sunflower disk after crushed, use body
The ethanol water of product a concentration of 65%~75% extracts 40h~50h, and filtering obtains filtrate, concentrates the medicinal extract of gained after filtrate,
The relative density of the medicinal extract is 1.1~1.15.
7. a kind of preparation method for treating the Chinese medicine composition of goat, which is characterized in that include the following steps：
Reishi sporule is taken, after carrying out Microwave Pretreatment to Reishi sporule under vacuum, liquid nitrogen deep freezing processing is carried out, freezes
Temperature to the Reishi sporule is less than or equal to -30 DEG C, then carries out air-flow crushing, obtains ganoderma spove powder；
After respectively crushing Poria cocos, plantago seed, celery seed and sunflower disk, it is 65%~75% ethanol water to use volumetric concentration respectively
Solution extracts 40h~50h, and filtering obtains filtrate, and the medicinal extract that relative density is 1.1~1.15 is obtained after concentrating filtrate, i.e., respectively
To tuckahoe extracts, Chinese herbaceous peony seed extract, Celeryseed extract and sunflower disk extract；
Take the ganoderma spove powder, the tuckahoe extracts, the Chinese herbaceous peony seed extract, the Celeryseed extract and institute
Sunflower disk extract is stated, each component is mixed, obtains the Chinese medicine composition.
8. preparation method according to claim 7, which is characterized in that the temperature of the microwave treatment is 30 DEG C~40 DEG C,
Time is 10min~20min.
9. application of any Chinese medicine composition of claim 1~6 in preparing the drug for treating goat.
10. using any Chinese medicine composition of claim 1~6 as the pharmaceutical preparation of active constituent.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111643583A (en) * | 2020-07-08 | 2020-09-11 | 常德市永春堂生物科技有限公司 | Traditional Chinese medicine composition for treating gout disease and preparation method and application thereof |
| CN113018414A (en) * | 2021-04-26 | 2021-06-25 | 西安得眠堂健康管理工作部 | Preparation method and device of composite peptide for relieving and improving gout symptoms and reducing blood uric acid |
| CN114304638A (en) * | 2022-01-25 | 2022-04-12 | 海南中食肽科生物科技有限公司 | Uric acid reducing composition and preparation method thereof |
-
2018
- 2018-08-29 CN CN201810993141.6A patent/CN108743669A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111643583A (en) * | 2020-07-08 | 2020-09-11 | 常德市永春堂生物科技有限公司 | Traditional Chinese medicine composition for treating gout disease and preparation method and application thereof |
| CN113018414A (en) * | 2021-04-26 | 2021-06-25 | 西安得眠堂健康管理工作部 | Preparation method and device of composite peptide for relieving and improving gout symptoms and reducing blood uric acid |
| CN113018414B (en) * | 2021-04-26 | 2022-02-15 | 西安得眠堂健康管理工作部 | Preparation method and device of composite peptide for relieving and improving gout symptoms and reducing blood uric acid |
| CN114304638A (en) * | 2022-01-25 | 2022-04-12 | 海南中食肽科生物科技有限公司 | Uric acid reducing composition and preparation method thereof |
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