CN108733978A - A kind of quaternary coding method of biocomputer - Google Patents
A kind of quaternary coding method of biocomputer Download PDFInfo
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- CN108733978A CN108733978A CN201810562667.9A CN201810562667A CN108733978A CN 108733978 A CN108733978 A CN 108733978A CN 201810562667 A CN201810562667 A CN 201810562667A CN 108733978 A CN108733978 A CN 108733978A
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N3/00—Computing arrangements based on biological models
- G06N3/002—Biomolecular computers, i.e. using biomolecules, proteins, cells
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- H—ELECTRICITY
- H03—ELECTRONIC CIRCUITRY
- H03M—CODING; DECODING; CODE CONVERSION IN GENERAL
- H03M7/00—Conversion of a code where information is represented by a given sequence or number of digits to a code where the same, similar or subset of information is represented by a different sequence or number of digits
- H03M7/30—Compression; Expansion; Suppression of unnecessary data, e.g. redundancy reduction
- H03M7/70—Type of the data to be coded, other than image and sound
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Abstract
The invention discloses a kind of quaternary coding methods of biocomputer, belong to biocomputer field.It includes making protein base chip；Four kinds of bases and quaternary number are established into mapping relations one by one；Single-stranded DNA fragments implement logical operation by basepairing rule；The base being successively read on Single-stranded DNA fragments, and translate into quaternary number.The present invention be it is a kind of using protein as chip base, using containing four kinds of gene bases deoxyribonucleoside acid encoding quaternary number, suitable for the quaternary coding method of biocomputer.
Description
Technical field
The invention mainly relates to biocomputer fields, refer in particular to a kind of quaternary coding method of biocomputer.
Background technology
Biocomputer is the most active subject with development potentiality of global high-tech area, its main raw material(s)
It is the protein molecule that biotechnology generates, and in this, as biochip.Biocomputer chip itself also has simultaneously
The function of row processing, 100,000 times faster than the computer of current latest generation of arithmetic speed, energy expenditure just corresponds to commonly
The part per billion of computer, the space for storing information only account for 1/1st.Therefore, research is suitable for biocomputer
Quaternary coding method has important value.
Invention content
The technical issues of present invention need to solve be：For technical problem of the existing technology, the present invention provides a kind of profit
Use protein as chip base, using containing four kinds of gene bases deoxyribonucleoside acid encoding quaternary number, be suitable for biometer
The quaternary coding method of calculation machine.
To solve the above-mentioned problems, solution proposed by the present invention is：A kind of quaternary coding side of biocomputer
Method, it includes the following steps,
S1, protein base chip is made；
S2, four kinds of bases and quaternary number are established into mapping relations one by one；
The adenine A, thymidine T, cytimidine C and guanine G describe 0,1,2 and 3 in the quaternary respectively；
S3, the Single-stranded DNA fragments implement logical operation by basepairing rule；
S4, the base being successively read on Single-stranded DNA fragments, and translate into quaternary number.
Using free adenine A, thymidine T, cytimidine C and the guanine G after bioprobe installing dyeing, according to people
Genoid pairing rules " adenine A is matched with thymidine T, cytimidine C and guanine G pairings " are translated on single stranded DNA successively
Quaternary number representated by each deoxynucleotide.
The step S1 includes following sub-step,
S11, using protein molecule as chip base material, which is provided with the single stranded DNA with certain base number
Segment and DNA segmentations enzyme, DNA organized enzymes, four kinds of free nitrogenous bases；
S12, the DNA fragmentation are made of the deoxynucleotide of certain amount, and per molecule deoxynucleotide is contained by a molecule
Nitrogen base, a molecule phosphoric acid and a molecule deoxyribose are formed by dehydrating condensation；
S13, four kinds of nitrogenous bases include adenine A, thymidine T, cytimidine C and guanine G.
The step S3 includes following sub-step,
S31, the free deoxyribonucleic acid molecule that micro-displacement can occur is placed around Single-stranded DNA fragments；
S32, under the action of DNA divides enzyme, any bit base can be by gene editing on the Single-stranded DNA fragments
Fall；
S32, under the action of DNA organized enzymes, any bit base for being fallen by editor on the Single-stranded DNA fragments can be by
It matches base and fills；
The quaternary number that S33, the Single-stranded DNA fragments are expressed passes through base modification and implements corresponding mathematical operation.
Compared with prior art, the present invention having the following advantages that and advantageous effect：
(1) the quaternary coding method of a kind of biocomputer of the invention, as a result of protein as chip base
Bottom effectively prevents the electromagnetic interference in calculating process, increases the stability and reliability of digital operation.
(2) the quaternary coding method of a kind of biocomputer of the invention, using the deoxynucleotide containing four kinds of bases
The DNA molecular segment of certain amount is formed, implements quick bio calculating in the presence of biology enzyme, not by DNA molecular base
Initial data of the same ordering as computer, realizes superpower quaternary parallel processing, significantly improves the meter of CPU
Calculate speed.
Description of the drawings
Fig. 1 is a kind of flow diagram of the quaternary coding method of biocomputer of the present invention.
The quaternary operation of the Single-stranded DNA fragments of Fig. 2 present invention and reading schematic diagram.
In figure, 1-adenine A, 2-thymidine T, 3-cytimidine C, 4-guanine G.
Specific implementation mode
Below with reference to the drawings and specific embodiments, invention is further described in detail.
Shown in Figure 1, a kind of quaternary coding method of biocomputer, it includes the following steps,
S1, protein base chip is made；
S2, four kinds of bases and quaternary number are established into mapping relations one by one；
Adenine A, thymidine T, cytimidine C and guanine G describe 0,1,2 and 3 in the quaternary respectively；
S3, Single-stranded DNA fragments implement logical operation by basepairing rule；
S4, the base being successively read on Single-stranded DNA fragments, and translate into quaternary number.
Using free adenine A, thymidine T, cytimidine C and the guanine G after bioprobe installing dyeing, according to people
Genoid pairing rules " adenine A is matched with thymidine T, cytimidine C and guanine G pairings " are translated on single stranded DNA successively
Quaternary number representated by each deoxynucleotide.
Step S1 includes following sub-step,
S11, using protein molecule as chip base material, which is provided with the single stranded DNA with certain base number
Segment and DNA segmentations enzyme, DNA organized enzymes, four kinds of free nitrogenous bases；
S12, DNA fragmentation are made of the deoxynucleotide of certain amount, and per molecule deoxynucleotide is by a molecule nitrogenous base
Base, a molecule phosphoric acid and a molecule deoxyribose are formed by dehydrating condensation；
S13, four kinds of nitrogenous bases include adenine A, thymidine T, cytimidine C and guanine G.
Step S3 includes following sub-step,
S31, the free deoxyribonucleic acid molecule that micro-displacement can occur is placed around Single-stranded DNA fragments；
S32, under the action of DNA divides enzyme, any bit base can be fallen by gene editing on Single-stranded DNA fragments；
S32, under the action of DNA organized enzymes, can be matched by it by any bit base that editor falls on Single-stranded DNA fragments
Base is filled；
The quaternary number that S33, Single-stranded DNA fragments are expressed passes through base modification and implements corresponding mathematical operation.
Shown in Figure 2, adenine A, thymidine T, cytimidine C and guanine G describe 0,1,2 in the quaternary respectively
With 3；DNA fragmentation primary data might as well be set as (32233210)4, wherein the 4th guanine G4 needs to change into thymidine
T2, the 7th thymidine T2 need to change into adenine A1, i.e. primary data needs are revised as (30231210)4, DNA at this time
Segment in the presence of biology enzyme, is simultaneously trimmed the 4th and the 7th gene using DNA segmentations enzyme, and lived from using DNA
Property enzyme ambient enviroment in assemble thymidine T2 and adenine A1；That is edited DNA fragmentation in Fig. 2；Finally, it is visited using biology
Free adenine A, thymidine T, cytimidine C and guanine G after needle installing dyeing, match according to human gene pairing rules
It is right, and the quaternary number on single stranded DNA representated by each deoxynucleotide is translated successively, the free gland on bioprobe is fast here
Purine A, thymidine T, cytimidine C and guanine G respectively represent 1,0,3 and 2 in quaternary number, i.e. bioprobe is cofree
Coding in the coding method and DNA fragmentation of base deoxynucleotide is complementary.
Claims (3)
1. a kind of quaternary coding method of biocomputer, it is characterised in that：It includes the following steps,
S1, protein base chip is made；
S2, four kinds of bases and quaternary number are established into mapping relations one by one；
The adenine A, thymidine T, cytimidine C and guanine G describe 0,1,2 and 3 in the quaternary respectively；
S3, the Single-stranded DNA fragments implement logical operation by basepairing rule；
S4, the base being successively read on Single-stranded DNA fragments, and translate into quaternary number；
Using free adenine A, thymidine T, cytimidine C and the guanine G after bioprobe installing dyeing, according to mankind's base
Because each on pairing rules " adenine A is matched with thymidine T, cytimidine C and guanine G pairings " successively translation single stranded DNA
Quaternary number representated by deoxynucleotide.
2. a kind of quaternary coding method of biocomputer according to claim 1, it is characterised in that：The step S1
Including following sub-step,
S11, using protein molecule as chip base material, which is provided with the Single-stranded DNA fragments with certain base number,
And DNA segmentations enzyme, DNA organized enzymes, four kinds of free nitrogenous bases；
S12, the DNA fragmentation are made of the deoxynucleotide of certain amount, and per molecule deoxynucleotide is by a molecule nitrogenous base
Base, a molecule phosphoric acid and a molecule deoxyribose are formed by dehydrating condensation；
S13, four kinds of nitrogenous bases include adenine A, thymidine T, cytimidine C and guanine G.
3. a kind of quaternary coding method of biocomputer according to claim 1, it is characterised in that：The step S3
Including following sub-step,
S31, the free deoxyribonucleic acid molecule that micro-displacement can occur is placed around Single-stranded DNA fragments；
S32, under the action of DNA divides enzyme, any bit base can be fallen by gene editing on the Single-stranded DNA fragments；
S32, under the action of DNA organized enzymes, can be matched by it by any bit base that editor falls on the Single-stranded DNA fragments
Base is filled；
The quaternary number that S33, the Single-stranded DNA fragments are expressed passes through base modification and implements corresponding mathematical operation.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110033090A (en) * | 2019-04-03 | 2019-07-19 | 济南大学 | A kind of interaction suite and its application method for DNA experiment |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100041869A1 (en) * | 2005-03-15 | 2010-02-18 | Mcgill University | Ionic liquid supported synthesis |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100041869A1 (en) * | 2005-03-15 | 2010-02-18 | Mcgill University | Ionic liquid supported synthesis |
Non-Patent Citations (2)
| Title |
|---|
| 居乃琥: "《酶工程手册》", 31 August 2011, 中国轻工业出版社 * |
| 菲利普•鲍尔: "《分子》", 28 February 2017, 译林出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110033090A (en) * | 2019-04-03 | 2019-07-19 | 济南大学 | A kind of interaction suite and its application method for DNA experiment |
| CN110033090B (en) * | 2019-04-03 | 2022-11-04 | 济南大学 | Interaction suite for DNA experiment and use method thereof |
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