CN108721630A - Vehicle for dispersing hydrophobic plant extracts - Google Patents
Vehicle for dispersing hydrophobic plant extracts Download PDFInfo
- Publication number
- CN108721630A CN108721630A CN201710627532.1A CN201710627532A CN108721630A CN 108721630 A CN108721630 A CN 108721630A CN 201710627532 A CN201710627532 A CN 201710627532A CN 108721630 A CN108721630 A CN 108721630A
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- CN
- China
- Prior art keywords
- plant extract
- hydrophobic
- hydrophobic plant
- molecular weight
- polyethylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 230000002209 hydrophobic effect Effects 0.000 title claims abstract description 107
- 239000000419 plant extract Substances 0.000 title claims abstract description 99
- 239000000203 mixture Substances 0.000 claims abstract description 44
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 37
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 37
- 239000003795 chemical substances by application Substances 0.000 claims description 61
- 239000000284 extract Substances 0.000 claims description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 36
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- 241000196324 Embryophyta Species 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 26
- 238000000605 extraction Methods 0.000 claims description 13
- 241000123107 Phellinus Species 0.000 claims description 10
- 241001486992 Taiwanofungus camphoratus Species 0.000 claims description 9
- 241001248610 Ophiocordyceps sinensis Species 0.000 claims description 7
- 235000001537 Ribes X gardonianum Nutrition 0.000 claims description 7
- 235000001535 Ribes X utile Nutrition 0.000 claims description 7
- 235000016919 Ribes petraeum Nutrition 0.000 claims description 7
- 244000281247 Ribes rubrum Species 0.000 claims description 7
- 235000002355 Ribes spicatum Nutrition 0.000 claims description 7
- 240000008397 Ganoderma lucidum Species 0.000 claims description 5
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims description 5
- 244000197580 Poria cocos Species 0.000 claims description 5
- 235000008599 Poria cocos Nutrition 0.000 claims description 5
- 238000009826 distribution Methods 0.000 claims description 5
- 241000123370 Antrodia Species 0.000 claims 1
- 235000008708 Morus alba Nutrition 0.000 claims 1
- 240000000249 Morus alba Species 0.000 claims 1
- 235000019441 ethanol Nutrition 0.000 description 30
- 229920002594 Polyethylene Glycol 8000 Polymers 0.000 description 14
- 239000004615 ingredient Substances 0.000 description 13
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 description 12
- 239000000243 solution Substances 0.000 description 11
- 239000003814 drug Substances 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 7
- 238000010438 heat treatment Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 241000411851 herbal medicine Species 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 5
- 239000006185 dispersion Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 4
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 230000001256 tonic effect Effects 0.000 description 4
- -1 2,2- dimethyl -1- propyl Chemical group 0.000 description 3
- MSXVEPNJUHWQHW-UHFFFAOYSA-N 2-methylbutan-2-ol Chemical compound CCC(C)(C)O MSXVEPNJUHWQHW-UHFFFAOYSA-N 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000001476 alcoholic effect Effects 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 229940124597 therapeutic agent Drugs 0.000 description 3
- 150000003648 triterpenes Chemical class 0.000 description 3
- UGMQOYZVOPASJF-OXUZYLMNSA-N (2r)-2-[(3s,5r,10s,13r,14r,17r)-3-hydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1CCC1=C2CC[C@]2(C)[C@@H]([C@@H](CCC(=C)C(C)C)C(O)=O)CC[C@]21C UGMQOYZVOPASJF-OXUZYLMNSA-N 0.000 description 2
- BBMCTIGTTCKYKF-UHFFFAOYSA-N 1-heptanol Chemical compound CCCCCCCO BBMCTIGTTCKYKF-UHFFFAOYSA-N 0.000 description 2
- MXLMTQWGSQIYOW-UHFFFAOYSA-N 3-methyl-2-butanol Chemical compound CC(C)C(C)O MXLMTQWGSQIYOW-UHFFFAOYSA-N 0.000 description 2
- HOMSOWZTBJWNHP-UHFFFAOYSA-N 5-chlorothiadiazole Chemical compound ClC1=CN=NS1 HOMSOWZTBJWNHP-UHFFFAOYSA-N 0.000 description 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- KQLDDLUWUFBQHP-UHFFFAOYSA-N Cordycepin Natural products C1=NC=2C(N)=NC=NC=2N1C1OCC(CO)C1O KQLDDLUWUFBQHP-UHFFFAOYSA-N 0.000 description 2
- UGMQOYZVOPASJF-UHFFFAOYSA-N Eburicoinsaeure Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC(=C)C(C)C)C(O)=O)CCC21C UGMQOYZVOPASJF-UHFFFAOYSA-N 0.000 description 2
- KPKYWYZPIVAHKU-UHFFFAOYSA-N Polyporenic acid C Natural products CC1(C)C(=O)CCC2(C)C3=CCC4(C)C(C(CCC(=C)C(C)C)C(O)=O)C(O)CC4(C)C3=CCC21 KPKYWYZPIVAHKU-UHFFFAOYSA-N 0.000 description 2
- 229960005305 adenosine Drugs 0.000 description 2
- OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 description 2
- OFEZSBMBBKLLBJ-UHFFFAOYSA-N cordycepine Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)CC1O OFEZSBMBBKLLBJ-UHFFFAOYSA-N 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000008236 heating water Substances 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- VDYCLYGKCGVBHN-UHFFFAOYSA-N pachymaic acid Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC(=C)C(C)C)C(O)=O)C(O)CC21C VDYCLYGKCGVBHN-UHFFFAOYSA-N 0.000 description 2
- SRDNLMOBFKJOSD-UHFFFAOYSA-N pachymic acid Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C(O)=O)C(O)CC21C SRDNLMOBFKJOSD-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000006104 solid solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010257 thawing Methods 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- APPOKADJQUIAHP-GGWOSOGESA-N (2e,4e)-hexa-2,4-diene Chemical compound C\C=C\C=C\C APPOKADJQUIAHP-GGWOSOGESA-N 0.000 description 1
- XADJANKGURNTIA-YEXRKOARSA-N (2r)-2-[(3s,5r,10s,13r,14r,16r,17r)-3,16-dihydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1CCC1=C2CC[C@]2(C)[C@@H]([C@@H](CCC(=C)C(C)C)C(O)=O)[C@H](O)C[C@]21C XADJANKGURNTIA-YEXRKOARSA-N 0.000 description 1
- BVIJQMCYYASIFP-UHFFFAOYSA-N 2-methylcyclopentan-1-ol Chemical compound CC1CCCC1O BVIJQMCYYASIFP-UHFFFAOYSA-N 0.000 description 1
- LOUORYQQOPCXGD-UHFFFAOYSA-N 2-methylpropan-1-ol Chemical compound CC(C)CO.CC(C)CO LOUORYQQOPCXGD-UHFFFAOYSA-N 0.000 description 1
- 244000283482 Alloteropsis cimicina Species 0.000 description 1
- 241000345998 Calamus manan Species 0.000 description 1
- 241000723347 Cinnamomum Species 0.000 description 1
- 241000190633 Cordyceps Species 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 235000017898 Digitaria ciliaris Nutrition 0.000 description 1
- RDMQPKIDHAFXKA-JNORPAGFSA-N Ganoderic Acid Am1 Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1CC(=O)C1=C2C(=O)C[C@]2(C)[C@@H]([C@@H](CC(=O)CC(C)C(O)=O)C)CC(=O)[C@]21C RDMQPKIDHAFXKA-JNORPAGFSA-N 0.000 description 1
- 229930182735 Ganoderic acid Natural products 0.000 description 1
- RXLRLJSRXDHQCH-ASNKJFCVSA-N Ganoderic acid R Chemical compound CC1(C)[C@H](OC(C)=O)CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@@H]([C@H](C\C=C(/C)C(O)=O)OC(C)=O)C)CC[C@@]4(C)C3=CC[C@H]21 RXLRLJSRXDHQCH-ASNKJFCVSA-N 0.000 description 1
- RXLRLJSRXDHQCH-WXUPVFRZSA-N Ganoderic acid R Natural products O([C@H]([C@@H](C)[C@@H]1[C@]2(C)[C@](C)(C=3C([C@]4(C)[C@H](C(C)(C)[C@H](OC(=O)C)CC4)CC=3)=CC2)CC1)C/C=C(\C(=O)O)/C)C(=O)C RXLRLJSRXDHQCH-WXUPVFRZSA-N 0.000 description 1
- 235000001188 Peltandra virginica Nutrition 0.000 description 1
- 229930182442 Poricoic acid Natural products 0.000 description 1
- 240000007313 Tilia cordata Species 0.000 description 1
- XADJANKGURNTIA-UHFFFAOYSA-N Tumulosic acid Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC(=C)C(C)C)C(O)=O)C(O)CC21C XADJANKGURNTIA-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- QCRFMSUKWRQZEM-UHFFFAOYSA-N cycloheptanol Chemical compound OC1CCCCCC1 QCRFMSUKWRQZEM-UHFFFAOYSA-N 0.000 description 1
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical class CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical class CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000000399 optical microscopy Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000010376 poriatin Substances 0.000 description 1
- 235000012950 rattan cane Nutrition 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a vehicle useful for dispersing hydrophobic plant extracts. The carrier comprises polyethylene glycol having an average molecular weight of about 8000 and polyethylene glycol having an average molecular weight of about 3350, wherein the weight ratio of polyethylene glycol having an average molecular weight of about 8000 to polyethylene glycol having an average molecular weight of about 3350 is about 1:1 to about 1: 5. The invention further relates to the use of the carrier and a colloidal composition comprising the carrier.
Description
Technical field
The present disclosure generally relates to a kind of supporting agent, especially system about one kind can be used for dispersing hydrophobic plant extract supporting agent,
Its purposes and colloidal compositions comprising it.
Prior art
In Chinese society, the Chinese herbal medicine based on plant for a long time and is widely used for looking after health or tonic body
Body, such as using Chinese herbal medicine as the method for treating various diseases, the body for especially complying with various solar term is taken a tonic or nourishing food to build up one's health, child changes into people
And the time of childbirth after women production raises, recovery even after being ill is taken a tonic or nourishing food to build up one's health, and all carries out medication or tonic with Chinese herbal medicine.
The use of Chinese traditional herbs is usually by plant after the processing of various methods, by medicine materical crude slice (prototype Chinese herbal medicine) in the form of
User is given in offer, and user voluntarily extracts method with traditional infusion water again, and the water-soluble extract of medicine materical crude slice as treatment or is mended
It supports, however the infusion water of this tradition extraction method can only obtain the water soluble ingredient in natural Chinese medicinal herb plant, have some hydrophobicitys to have
Ingredient is imitated, is wasted because being not easy or being insoluble in water and throws aside and can not utilize, quite unfortunately.
With the exploitation of various scientific extractor tools and process conditions, many achievements in research confirm natural Chinese medicinal herb plant
In hydrophobic combination effect and be no less than water soluble ingredient, even be its treatment leading indicator ingredient.Such as by wild
And the Antrodia camphorata fructification that Cinnamomum kanahirai hay linden is turned out, main active ingredient triterpenes is hydrophobic combination, needs to use
90% to 95% alcohol beginning can extract；Anticancer component in Phellinus fructification need to be extracted using 70% alcohol；And the winter
For the ingredients such as cordycepin and adenosine when being extracted using 50% alcohol, the content of gained is higher in worm summer grass.These hydrophobicitys
Extract back dissolving but can be insoluble in water in the various concentration alcohol to extract easily, be less prone to effectively be inhaled by human body
It receives, furthermore, even if belonging to hydrophobic combination, the hydrophobic extraction object with different hydrophobic degrees (hydrophobicity) is based on it
Alcohol concentration needed for back dissolving is different, is also difficult to merge use.Therefore, these different hydrophobic plant extracts, though it is known
With good physiological activity, but it is restricted in the development and application range of functional food or pharmaceuticals.
Therefore, how to overcome the problems, such as that Chinese herbal medicine hydrophobic combination is difficult to apply it, be one of industry significant challenge.
Invention content
The present invention provides a technology, can coat and be converted into the shape being easily dispersed in aqueous solution the hydrophobic combination of plant
Formula is absorbed and utilized with facilitating by human body, furthermore, the technical operation of the present invention is simple, can make processing procedure cost reduction, makes its application
More scientificization, judicial convenience, for natural plants as the raw material of International Plant new drug development and the extraction of natural Chinese medicinal herb
Using upper, the territory of its application can be substantially extended.
The present invention provides a kind of supporting agent, by specific ingredient and proportioning, and can be used for dispersing hydrophobic plant extraction
Object person.
The present invention provides a kind of supporting agent, including polyethylene glycol and average molecular weight that average molecular weight is about 8000 are about
3350 polyethylene glycol, the poly- second that the polyethylene glycol and the average molecular weight that wherein the average molecular weight is about 8000 are about 3350
The weight ratio of glycol is about 1:1 to about 1:5.
The present invention separately provides a kind of purposes of above-mentioned supporting agent, is used to disperse a Hydrophobic plant extract.
The present invention separately provides a kind of dispersing method of Hydrophobic plant extract, is by an at least Hydrophobic plant extract
It is scattered in above-mentioned supporting agent.
The present invention provides a kind of manufacturing method of colloidal compositions again, which includes an at least Hydrophobic plant
Extract and a carrier, the manufacturing method include to disperse an at least Hydrophobic plant extract in the load with above-mentioned dispersing method
In body.
The present invention provides a kind of colloidal compositions again, including above-mentioned supporting agent and a Hydrophobic plant extract.
The present invention provides a kind of colloidal compositions again, is with obtained by above-mentioned manufacturing method.
Description of the drawings
Fig. 1 shows the optical microscopy map of the colloidal compositions of one embodiment of the invention；
Fig. 2 shows the granularmetric analysis result of the colloidal compositions of one embodiment of the invention.
Embodiment
The present invention provides a kind of supporting agent, including polyethylene glycol and average molecular weight that average molecular weight is about 8000 are about
3350 polyethylene glycol, the poly- second that the polyethylene glycol and the average molecular weight that wherein the average molecular weight is about 8000 are about 3350
The weight ratio of glycol is about 1:1 to about 1:5.
Range is often expressed as " about " particular value and/or herein to " about " another particular value.When state this
When class range, an embodiment be include a particular value and/or the range to another particular value.Similarly, when value by
When " about " being expressed as approximation using word, it should be understood that particular value can form another embodiment.Additionally, it is understood that each range it
Each endpoint is all significant, end point and the existing correlation of another endpoint, also independently of one another.
Term " supporting agent " as used herein, also known as " excipient ", it is therapeutic agent to mean itself not, and is used as using
In supporting agent and/or diluent and/or adjuvant or mediator that therapeutic agent is transferred to individual, or it is added in composite and is adjusted with improving
Processing or storage properties or permission with object contribute to the dosage unit of composition to form the object of the dosage unit suitable for administering
Matter.Supporting agent should not destroy the pharmacological activity of therapeutic agent, and should nothing when to be enough to transmit the dosage administering of the medicament of therapeutic dose
Toxicity.
According to the supporting agent of the present invention, including polyethylene glycol (polyethylene glycol), is in specific words mean molecule
Polyethylene glycol (the abbreviation PEG- that the polyethylene glycol (abbreviation PEG-8000) and average molecular weight that amount is about 8000 are about 3350
3350).For example, the molecular weight of PEG-8000 can be about 7000g/mol to about 9000g/mol；And the molecule of PEG-3350
Amount can be about 3000g/mol to about 3700g/mol.In addition, the molecular weight of polyethylene glycol can pass through mass spectrograph (mass
Spectrometry it) measures, or its molecular weight is pushed away with counter by its viscosity is measured.
According to the supporting agent of the present invention, the weight ratio of PEG-8000 and PEG-3350 is about 1:1 to about 1:5；Preferably from about 1:2
To about 1:3；More preferably system is about 1:2.5.By specified molecular weight and specified weight than the use of polyethylene glycol, make the present invention's
Supporting agent can be applied to dispersion various plants type and the Hydrophobic plant extract that all differs of hydrophobic degree, more can will be a variety of
Hydrophobic plant extract common distribution is in single supporting agent.
In one of present invention preferred embodiment, which additionally comprises the poly- second two that average molecular weight is about 400
Alcohol (abbreviation PEG-400).For example, the molecular weight of PEG-400 can be about 380g/mol to about 420g/mol.PEG-8000 with
Total usage amount of PEG-3350 and the weight ratio of the usage amount of PEG-400 are preferably from about 1:1 to about 1:10；Even more preferably about 1:
3 to about 1:6；Especially preferably about 1:4.
According to the present invention, there is no restriction for order by merging and method between the polyethylene glycol with different average molecular weight, in
In one of present invention specific embodiment, for can be in solid-like comprising the mixing between sheet or powdered solid polyethylene glycol
After state mixing, heats and obtain an even phase liquid condition；In another specific embodiment of the present invention, it is poly- that each solid is heated in advance
Ethylene glycol, then row are obtained by mixing an even phase liquid condition；In the still another embodiment of the present invention, solid polyethylene glycol system
Addition has been in the polyethylene glycol of liquid condition, then goes to heat and be obtained by mixing an even phase liquid condition.On the other hand, normal for room temperature
For the pressure as polyethylene glycol of liquid, it can also be mixed with solid polyethylene glycol according to aforementioned schemes.
In one of present invention preferred embodiment, according to the supporting agent system of the present invention first by PEG-8000 and PEG-
After 3350 are heated to thawing, uniformly mix and form even phase solution.Such as the PEG-8000 and PEG-3350 that weighing quantifies are consolidated
Body is placed in a container, with heating water bath, until when it starts to melt, then agitated mixing etc..It is above-mentioned comprising PEG-8000 and
Under room temperature the kenel of solid solution may be presented, and can be in row dissolves by heating again before in the supporting agent of PEG-3350.
In another preferred embodiment of the present invention, first heating and melting and according to weight ratio mixing PEG-8000 and
PEG-3350 adds PEG-400 and uniformly mixes.Thus, the supporting agent lies in the solution in viscous liquid state under room temperature, therefore
Using upper more convenient.
In another preferred embodiment of the present invention, other diluents are added in the supporting agent according to use demand,
To adjust viscosity, concentration and volume, it is suitable for other diluents of the present invention including but not limited to water and alcohol etc..
Preferably, it is an even phase solution according to the supporting agent system of the present invention, that is, the polyethylene glycol of average molecular weight difference can
Uniformly mixes and dissolve each other.
The present invention separately provides a kind of purposes of above-mentioned supporting agent, is used to disperse a Hydrophobic plant extract.
The present invention provides a kind of dispersing method of Hydrophobic plant extract again, is by an at least Hydrophobic plant extract
It is scattered in above-mentioned supporting agent.
In the present invention, " plant " does not limit its type.For example, can be arbor, shrub, rattan class, green grass,
Fern and green alga etc., and can be Chinese medicine, herbal medicine or non-medicinal plant, furthermore, " plant " of the present invention more may include algae
And Mycophyta etc..Whole plant is can refer to according to the plant of the present invention, is also referred to as any part of plant.Implement in the present invention one
In scheme, plant includes ganoderma lucidum, Antrodia camphorata, Phellinus, Poria cocos and cordyceps sinensis etc., and may include its a part or whole part, such as only
Including its fructification etc..
According to the plant extract system of the present invention by plant via extraction, and obtain extract.For example, plant can be with
First after drying, processing, then it is broken into fritter or through crushing, is then extracted with fluid (such as liquid or supercritical fluid)
It takes, the ingredient that plant includes is made to be dissolved in extraction fluid, and obtain plant extract, or optionally again through drying.Due to
The active ingredient that various plants are included is different, can be by selection different extraction fluid and ratio, and adjusts plant extraction
The ingredient that object includes.
In the present invention, " hydrophobicity " means the characteristic mutually exclusive with water, also that is, meaning the spy for being insoluble in water
Property, " hydrophobic degree " means the degree of hydrophobicity.When the hydrophobic degree of substance is higher, then more it is difficult to soluble in water；Conversely, substance is dredged
Water degree is low, then is easier to soluble in water.Therefore, its " Hydrophobic plant extract " of the present invention, mean with hydrophobicity it
Plant extract is the hydrophobic combination included in plant extract, and such as, but not limited to polarity is relatively low and insoluble or indissoluble
Ingredient in water.Also that is, Hydrophobic plant extract system defines the characteristic that such components are insoluble in water, and it is unrestricted its
The mode of acquisition.The Hydrophobic plant extract, which can be extracted for plant via organic solution, to be obtained.
Preferably, it is alcohol extract according to the Hydrophobic plant extract system of the present invention, that is, uses alcohol extraction plant institute
The extract obtained.Say that its " alcohol " word means linear chain or branched chain, tool substitution or do not have substitution, unit or polynary, full herein
And/or the alcohol of unsaturation, preferably it is not have substitution, unit and saturated alcohols.On the other hand, the preferred system of the alcohol is with 1 to 7 carbon
The alcohol of number, the more preferably alcohol of 1 to 4 carbon number.It, should be with the alcohol of 1 to 7 carbon number in one of present invention preferred embodiment
System is methanol, ethyl alcohol, normal propyl alcohol (n-propanol), isopropanol (isopropanol), n-butanol, isobutanol (iso-
Butanol), sec-butyl alcohol (sec-butanol), the tert-butyl alcohol (tert-butanol), 1- amylalcohols, 2- amylalcohols, 3- amylalcohols, 2- first
Base-n-butyl alcohol, 2- methyl -2- butanol, 3- methyl -2- butanol, 3- methyl-1-butanols, 2,2- dimethyl -1- propyl alcohol, 1- hexanols,
2,4- hexadiene -1- alcohol, 2- methyl-cyclopentanol, cyclohexanol, 1-heptanol, 2- enanthol or suberol；Especially preferably, the alcohol system
For methanol or ethyl alcohol；Most preferably, which is ethyl alcohol.The alcohol can be used alone or mix a variety of uses.
The preferred system of alcohol sayed herein is aqueous solution, and concentration is preferably the alcoholic solution from about 20% to about 99.9%；
More preferably from the alcoholic solution of about 30% to about 99.9%；Especially preferably from the alcoholic solution of about 40% to about 98.0%.
" Hydrophobic plant extract " of the present invention is including but not limited to ganoderma lucidum, Antrodia camphorata, Phellinus, Poria cocos and worm summer in winter
The extract of grass.
For example, ganoderma lucidum extract preferably comprise the triterpenes chemistry that is isolated from ganoderma lucidum sporocarp and spore at
Point, the triterpene compound is including but not limited to ganoderic acid (ganoderic acid R).
For example, Antrodia camphorata extract preferably comprises triterpenes, is the alcohol water that can be used concentration higher for hydrophobicity
Solution (such as alcohol water blend of percent by volume 90~95%) is extracted.
For example, Phellinus extract slightly extracts object (PLEE) comprising Phellinus ethyl alcohol, can be used percent by volume about 70% it
Alcohol water blend is extracted.
For example, tuckahoe extract includes triterpene compound, su-fuling (Poriatin), pachymic acid (Pachymic
Acid), block acid (Tumulosic acid), polyporenic acid C (polyporenic acid C), eburicoic acid (Ebricoic
Acid), Poria cocos eo-acid (poricoic acid) etc.；The alcohol water blend of usable percent by volume about 90~95% is extracted
It takes.
For example, cordyceps sinensis extract includes cordycepin and adenosine, and the alcohol of percent by volume about 50% can be used
Aqueous solution is extracted.
It can be only by single Hydrophobic plant extract point according to the dispersing method of the Hydrophobic plant extract of the present invention
It dissipates in supporting agent；Alternatively, can be by the different Hydrophobic plant extract common distribution of several hydrophobic degrees in supporting agent.Yu Ben
In one of invention specific embodiment, it is intended at least Hydrophobic plant extract disperse and is planted comprising one first hydrophobicity
Object extract and one second Hydrophobic plant extract, the hydrophobic degree of the first Hydrophobic plant extract are second hydrophobic higher than this
Property plant extract hydrophobic degree, this method includes to extract the first Hydrophobic plant extract and second Hydrophobic plant
Object common distribution is in the supporting agent.
In one of present invention specific embodiment, when the dispersing method is used to disperse the hydrophobicity of several hydrophobic degree differences
When plant extract, preferably first several plants extract can be arranged according to hydrophobic degree, and first by hydrophobic degree soprano (least
It is soluble easily in water) be scattered in the supporting agent, subsequently add the slightly lower person of hydrophobic degree and disperse it, finally just be added hydrophobic degree it is minimum it
Plant extract.In detail, it is that one first Hydrophobic plant extract is disperseed with above-mentioned supporting agent in one embodiment of this invention
And one second Hydrophobic plant extract, the wherein hydrophobic degree of the first Hydrophobic plant extract are planted higher than second hydrophobicity
The first Hydrophobic plant extract is first scattered in the supporting agent by the hydrophobic degree of object extract, is continued and is planted second hydrophobicity
Object extract is scattered in the supporting agent.
In one of present invention specific embodiment, the dispersing method of the Hydrophobic plant extract comprises the steps of：
(a) an at least Hydrophobic plant extract is scattered in the polyethylene glycol and be somebody's turn to do that the average molecular weight is about 8000
In the polyethylene glycol that average molecular weight is about 3350, to form a dispersive composition；And
(b) dispersive composition is scattered in the polyethylene glycol that the average molecular weight is about 400.
In this specific embodiment, when which includes PEG-8000, PEG-3350 and PEG-400, wherein in advance
PEG-8000 and PEG-3350 is set to form an even phase solution, such as heating PEG-8000 and PEG-3350 up to thawing completely, then
The Hydrophobic plant extract is added, to form the dispersive composition, the dispersive composition is then scattered in PEG-400 again
In.
Effect to improve dispersion preferably lies in heating according to the dispersing method of the Hydrophobic plant extract of the present invention
By this, at least a Hydrophobic plant extract is scattered in the supporting agent under state.The preferred system of the temperature of heating can make the supporting agent complete
Melt, and the rotten person of the active ingredient for avoiding the Hydrophobic plant extract from including, for example, in about 60 DEG C to about 80 DEG C
At a temperature of heat, the means of heating are also without limitation, such as use the modes such as water-bath, oil bath.
To improve the effect of dispersion, the extraction that homogenizes is additionally comprised according to the dispersing method of the Hydrophobic plant extract of the present invention
Take the object supporting agent and an at least Hydrophobic plant extract.This homogenization step can independently be implemented, or simultaneously with dispersion steps
Implement, or merge implementation with dispersion, heating stepses simultaneously, the means to homogenize are shaken including but not limited to via stirring or ultrasonic
The modes such as swing.For example, be usable ultrasonic vibrating or homogenizer (such as rotating speed 15,000rpm/min to 20,
000rpm/min) with Hydrophobic plant extract and the supporting agent of homogenizing, make supporting agent can uniform coated by hydrophobic plant extract, and
Smaller particless are formed, with sharp follow-up use.
It is that the supporting agent can be made to coat the hydrophobicity to plant according to the ratio system of the supporting agent of the present invention and Hydrophobic plant extract
Object extract, and can make whole colloidal compositions that still there is the effect person of the expectation, in one embodiment of this invention, wherein this is extremely
The weight ratio of a few Hydrophobic plant extract and the supporting agent is about 1:10 to about 1:50.If supporting agent ratio is too low, possibly can not
It is completely dispersed Hydrophobic plant extract；Conversely, if supporting agent ratio is excessively high, equal to make active ingredient by Macrodilution, it is obtained
Colloidal compositions volume it is big, it is inconvenient for use.
For expand Hydrophobic plant extract application, according to the supporting agent of the present invention can reconcile simultaneously Hydrophobic plant extract
Object is with hydrophilic plant extract in same colloidal compositions, and in one of present invention preferred embodiment, this is hydrophobic
The dispersing method of property plant extract, which additionally comprises, is scattered in hydrophilic plant extract in the supporting agent.
The hydrophilic plant extract means the plant extract ingredient being dissolvable in water in water, including but not limited to currant
Extract.
Process according to the invention can convert opposed polarity natural plant extraction object to an even phase aqueous solution, with difference
The polyethylene glycol of molecular weight is that carrier converts the opposed polarity hydrophobic combination of plant extract to an even phase aqueous solution, is put down
Equal granularity is about 250nm, and grain size is small more to be had in the absorption of sharp human body, and particle diameter distribution is uniform, and the method can make Hydrophobic plant
Extract has good water solubility, is conducive to the exploitation in dosage form and purposes, gain Hydrophobic plant extract development and application
In on health food and pharmaceuticals field, this technology has the novelty that convenience and dosage form are applied.
The present invention provides a kind of manufacturing method of colloidal compositions again, which includes an at least Hydrophobic plant
Extract and a carrier, the manufacturing method include to disperse an at least Hydrophobic plant extract in the load with above-mentioned dispersing method
In body.
The present invention provides a kind of colloidal compositions again, including above-mentioned supporting agent and a Hydrophobic plant extract.
The present invention provides a kind of colloidal compositions again, is with obtained by above-mentioned manufacturing method.
It is used for dispersing hydrophobic plant extract according to the supporting agent system of the present invention, though it is reluctant to be limited by theory, it is believed that
Hydrophobic plant extract ingredient can be made to be dispersed in coated by hydrophobic plant extract ingredient according to the supporting agent of the present invention
To form colloidal compositions in supporting agent, and it is not easy to precipitate.Furthermore if above-mentioned colloidal compositions are incorporated in water or aqueous solution,
The supporting agent can also maintain the dispersity of Hydrophobic plant extract, and form soliquid.
Above-mentioned colloidal compositions are in application, be that can be presented with different shape according to its supporting agent ingredient.As described above,
Including under room temperature, the kenel of solid solution may be presented in the supporting agent of PEG-8000 and PEG-3350, thus include such supporting agent it
Solid-type may be also presented in colloidal compositions, and can make dripping pill etc., with convenient for users to taking.In addition, above-mentioned include
The supporting agent of PEG-400 can then be in a liquid state under room temperature, therefore to include the colloidal compositions of such supporting agent can be modulated to paste.Cooperation
Use demand, above-mentioned colloidal compositions can also further add water to form dilution liquid.
Preferably, which additionally comprises aforementioned hydrophilic plant extract.
Non-limiting embodiment, which helps to have usual skill in the technical field of the invention, below implements this hair
It is bright.These embodiments are not construed as exceedingly limiting the present invention.Persond having ordinary knowledge in the technical field of the present invention can be
Embodiment described herein is modified and changed without departing from the spirit of the present invention or in the case of scope, and still falls within this
The range of invention.
Embodiment
The preparation of carrier：
The PEG-3350 for taking the PEG-8000 and 10g of 10g is heated in 60~80 DEG C of water-baths and is stirred to complete and melts,
An even phase solution is formed, the PEG-400 for separately weighing 80g is spare.
Hydrophobic plant extract and hydrophilic plant extract：
The Chinese medicinal herbs fresh goods such as Antrodia camphorata fructification, Phellinus fructification and cordyceps sporophore are taken respectively, it is cold through crushing
Be lyophilized it is dry after, extracted respectively with 95%, 70% and 50% alcohol, by extract gained extract once again carry out freezing do
It is dry.
It is spare to be lyophilized after drainage extraction object excessively after separately taking currant fresh goods is clean to drain.
Aforementioned freeze-dried Antrodia camphorata extract, Phellinus extract, cordyceps sinensis extract and currant are extracted
Object is dissolved in pure water respectively, wherein only currant extract is fully soluble in water, other three kinds of extracts are neither soluble easily in water,
Therefore Antrodia camphorata extract, Phellinus extract and cordyceps sinensis extract belong to Hydrophobic plant extract；Currant extract
Belong to hydrophilic plant extract.
The preparation of colloidal compositions：
Antrodia camphorata extract, the 1g of 1g are sequentially added in the aforementioned even phase solution of prepared PEG-8000 and PEG-3350
Phellinus extract and 1g cordyceps sinensis extract, heating water bath (temperature 60 C is to 80 DEG C), which is simultaneously stirred to complete, to be melted, with
Obtain a dispersive composition.
Then, above-mentioned dispersive composition is placed in ultrasonic vibrating water bath, at a temperature of 40 DEG C to 60 DEG C, is added
The aforementioned PEG-400 weighed, and fully after homogeneous, that is, obtained with homogenizer (rotating speed 15,000rpm/min to 20,000rpm/min)
Obtain one first colloidal compositions.
Aforementioned colloidal compositions further are added in the currant extract of 1g, once again with homogenizer (rotating speed 15,
000rpm/min to 20,000rpm/min) fully after homogeneous, that is, it includes Hydrophobic plant extract and hydrophily simultaneously to obtain one
Second colloidal compositions of plant extract.
The property of colloidal compositions：
It takes 100ml pure water to be placed in vial, which is added dropwise in water, be gently mixed quickly i.e.
The even phase aqueous solution of milky of uniform-light transmission can be presented, when being irradiated with laser beam, observable obtains laser beam straight uniform and passes through, institute
Projection, which penetrates to white background also to present, concentrates luminous point, represents Hydrophobic plant extract and is uniformly mixed with water, shows not homopolarity
Property at point Hydrophobic plant extract be dispersed in supporting agent, and then can be dispersed in water and form colloidal suspension
Liquid.
First colloidal compositions are separately diluted into 200 times (1g/200ml) with water, then with light microscope (Leica DMR
(200x)) observation, the results are shown in Figure 1, it is seen that the colloidal compositions are dispersed in water.
It separately carries out analyzing and calculating standard deviation, the coefficient of variation three times with particle size analyzer (Zetasizer-ZS), as a result show
Show such as table 1 and Fig. 2.
Table 1：Granularmetric analysis result
The analysis condition of particle size analyzer is set as temperature：25℃；Refractive index：1.33；Light analyses tubing type：DTS0012
(deserted granularmetric analysis light analysis pipe)；Viscosity：0.8872cPs；Scanning range：0~3000nm.It can by above-mentioned granularmetric analysis result
Know, which can be dispersed in water, and form the particle of average grain diameter about 250nm.
The principles and effects of above-described embodiment only to illustrate the invention, are not intended to limit the present invention.Technology belonging to the present invention
Have modification and variation that usual skill makes above-described embodiment in field still without prejudice to the spirit of the present invention.The power of the present invention
Listed by claims that sharp range should be as be described hereinafter.
Claims (13)
1. a kind of supporting agent, including the poly- second two that polyethylene glycol and average molecular weight that average molecular weight is about 8000 are about 3350
Alcohol, the weight ratio for the polyethylene glycol that the polyethylene glycol and the average molecular weight that wherein the average molecular weight is about 8000 are about 3350
It is about 1:1 to about 1:5.
2. supporting agent as described in claim 1, additionally comprises the polyethylene glycol that average molecular weight is about 400.
3. supporting agent as claimed in claim 2, wherein the polyethylene glycol and average molecular weight that the average molecular weight is about 8000 be
The weight ratio of the usage amount for the polyethylene glycol that total usage amount of about 3350 polyethylene glycol and the average molecular weight are about 400 is about
1:1 to about 1:10.
4. a kind of dispersing method of Hydrophobic plant extract is that an at least Hydrophobic plant extract is scattered in claim
In supporting agent described in any one of 1 to 3.
5. the dispersing method of Hydrophobic plant extract as claimed in claim 4, wherein the Hydrophobic plant extract system is ox
The extract of antrodia, Phellinus or cordyceps sinensis.
6. the dispersing method of Hydrophobic plant extract as claimed in claim 5, wherein an at least Hydrophobic plant extract
Including one first Hydrophobic plant extract and one second Hydrophobic plant extract, the first Hydrophobic plant extract is to be dredged
Water degree (hydrophobicity) is higher than the hydrophobic degree of the second Hydrophobic plant extract, and this method includes that this is first hydrophobic
Property plant extract and the second Hydrophobic plant extract common distribution are in the supporting agent.
7. the dispersing method of Hydrophobic plant extract as claimed in claim 6, including：
(a) an at least Hydrophobic plant extract is scattered in polyethylene glycol that the average molecular weight is about 8000 and this is averaged
In the polyethylene glycol that molecular weight is about 3350, to form a dispersive composition；And
(b) dispersive composition is scattered in the polyethylene glycol that the average molecular weight is about 400.
8. the dispersing method of Hydrophobic plant extract as claimed in claim 7, wherein an at least Hydrophobic plant extract
And the weight ratio of the supporting agent is about 1:10 to about 1:50.
9. the dispersing method of Hydrophobic plant extract as claimed in claim 8 is additionally comprised hydrophilic plant extract point
It dissipates in the supporting agent.
10. a kind of colloidal compositions, including the supporting agent described in any one of claims 1 to 3 and Hydrophobic plant extraction
Object.
11. colloidal compositions as claimed in claim 10, wherein the Hydrophobic plant extract system is ganoderma lucidum, Antrodia camphorata, mulberry
Yellow, Poria cocos or cordyceps sinensis extract.
12. colloidal compositions as claimed in claim 11, additionally comprise a hydrophilic plant extract.
13. colloidal compositions as claimed in claim 12, wherein the hydrophilic plant extract include currant extract.
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| TW106113020A TWI661841B (en) | 2017-04-19 | 2017-04-19 | Carrier for dispersing hydrophobic botanical extract |
| TW106113020 | 2017-04-19 |
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| TW201838622A (en) | 2018-11-01 |
| TWI661841B (en) | 2019-06-11 |
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Application publication date: 20181102 |