CN108720897A - Composite wave therapeutic equipment and treatment system - Google Patents
Composite wave therapeutic equipment and treatment system Download PDFInfo
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- CN108720897A CN108720897A CN201810741583.1A CN201810741583A CN108720897A CN 108720897 A CN108720897 A CN 108720897A CN 201810741583 A CN201810741583 A CN 201810741583A CN 108720897 A CN108720897 A CN 108720897A
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- 238000011282 treatment Methods 0.000 title claims abstract description 56
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- 238000002604 ultrasonography Methods 0.000 claims abstract description 39
- 239000000523 sample Substances 0.000 claims description 32
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- IPJDHSYCSQAODE-UHFFFAOYSA-N 5-chloromethylfluorescein diacetate Chemical compound O1C(=O)C2=CC(CCl)=CC=C2C21C1=CC=C(OC(C)=O)C=C1OC1=CC(OC(=O)C)=CC=C21 IPJDHSYCSQAODE-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/225—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
- A61H23/02—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive
- A61H23/0245—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive with ultrasonic transducers, e.g. piezoelectric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B2017/22005—Effects, e.g. on tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B2017/22005—Effects, e.g. on tissue
- A61B2017/22011—Combined types of vibration, e.g. ultrasonic and electrohydraulic
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Abstract
The present invention relates to a kind of composite wave therapeutic equipment and treatment systems.Composite wave therapeutic equipment includes:Ultrasonic wave generating unit (10), for therapeutic ultrasound to occur;Shock wave generating unit (20), for therapeutic shock wave to occur;With combination wave generator (30), it is coupled respectively with the ultrasonic wave generating unit (10) and the shock wave generating unit (20), for the therapeutic ultrasound and the therapeutic shock wave to be combined into composite wave, and the composite wave is applied to position to be treated.The present invention can improve therapeutic effect, reduce the side effect for the treatment of wave.
Description
Technical field
The present invention relates to field of medical device more particularly to a kind of composite wave therapeutic equipment and treatment systems.
Background technology
Therapeutic ultrasound be it is a kind of acoustic wave energy is transferred to destination organization, with cause various biological act on ultrasound
Wave.As a kind of mechanical energy form of pressure wave, therapeutic ultrasound can act on tissue and form micromechanics pressure,
And cause the biochemical change of cell and molecular level.Currently, therapeutic ultrasound be mainly used in organization healing, nerve/
Myocyte regenerates and promotes the medical fields such as cardiovascular regeneration.
Therapeutic shock wave is a kind of non-invasively treating method, similar with ultrasonic wave, has pressure effect, tension effect
And cavitation effect.Therapeutic shock wave can pass through body fluid and tissue to reach affected part, and the medium contacted in human body according to it is not
Together, such as the soft tissues and skeletal tissue etc. such as fat, tendon, ligament, the interface of acoustic impedance tissue not will produce different
Mechanical stress is shown as to tensile stress caused by tissue and compression.In addition, the pulse tail negative wave of therapeutic shock wave
Section can also cause cavitation effect, can be used for dredging the fine vascular of occlusion, the adhesion for soft tissue of joint of loosening.Currently, therapeutic
Shock wave is mainly used in the disease in terms of calculus, analgesia and bone.
It is studied through inventor, there is certain limitation and side effects for above two treatment technology.The sound of ultrasonic wave
Wave energy may cause local temperature to increase, to be adversely affected to the part enzymes activity in human body.Ultrasonic wave and
The cavitation effect of shock wave may destroy histiocytic integrality so that the capillary of tissue damages, to go out
Blood, scar or even neurotrosis.
Invention content
The purpose of the present invention is to propose to a kind of composite wave therapeutic equipment and treatment systems, can improve therapeutic effect, reduce
Treat the side effect of wave.
To achieve the above object, the present invention provides a kind of composite wave therapeutic equipments, including:
Ultrasonic wave generating unit, for therapeutic ultrasound to occur;
Shock wave generating unit, for therapeutic shock wave to occur;With
Combination wave generator couples respectively with the ultrasonic wave generating unit and the shock wave generating unit, and being used for will
The therapeutic ultrasound and the therapeutic shock wave are combined into composite wave, and the composite wave is applied to portion to be treated
Position.
Further, the therapeutic ultrasound is low energy pulses ultrasonic wave.
Further, the ultrasonic frequency range of the low energy pulses ultrasonic wave be 1~2MHz, the sound intensity ranging from 0.05~
3W/cm2。
Further, the ultrasonic frequency range of the low energy pulses ultrasonic wave is 1.5~1.7MHz.
Further, the therapeutic shock wave is low-intensity external knock wave.
Further, the frequency range of the low-intensity external knock wave be 1~6Hz, energy range be 0.01~
0.7mJ/mm2。
Further, the composite wave is the treatment shock wave and treatment ultrasonic wave along sequential combination.
Further, further include:
Controller, respectively with the ultrasonic wave generating unit, the shock wave generating unit and the combination wave generator
Signal connects, for the parameter to the parameter of the therapeutic ultrasound, the therapeutic shock wave or the composite wave respectively
Synthetic parameters be adjusted.
Further, further include treatment probe and probe adjusting mechanism, the combination wave generator setting is in the treatment
The top of probe, the probe adjusting mechanism are operably coupled with treatment probe, for adjusting the treatment probe
Pose.
Further, the probe adjusting mechanism includes mechanical arm, and the treatment probe is mounted on the end of the mechanical arm
Portion, the composite wave therapeutic equipment further includes controller, and the controller is believed with the mechanical arm and treatment probe respectively
Number connection, drives the treatment to pop one's head in for controlling the mechanical arm and is moved to position to be treated.
Further, the ultrasonic wave generating unit further includes the first adjustment lens, is connected with the controller in a signal way., and is used
In the type for adjusting the therapeutic ultrasound that the ultrasonic wave generating unit is exported to the combination wave generator.
Further, the shock wave generating unit further includes second adjustment lens, is connected with the controller in a signal way., and is used
In the type for adjusting the therapeutic shock wave that the shock wave generating unit is exported to the combination wave generator.
Further, the type includes one kind in plane wave, dispersive wave, focus wave and semi-focusing wave.
Further, further include:
Multi-media player unit is connected with the controller in a signal way., the sound for playing auxiliary use and/or auxiliary treatment
Video information.
To achieve the above object, the present invention also provides a kind for the treatment of systems, including:
Composite wave therapeutic equipment above-mentioned;With
Network cloud platform is communicated to connect with the composite wave therapeutic equipment, for being provided to the composite wave therapeutic equipment
Therapeutic scheme.
Further, the network cloud platform includes:
Information memory cell, identity identification information and medical record information for storing patient;
Scheme storage unit, for storing the therapeutic scheme corresponding to various disease and/or different patients;
Scheme issuance unit, for after the identity identification information for confirming patient, being asked according to the download from patient terminal
It asks, corresponding therapeutic scheme is issued to the associated composite wave therapeutic equipment of the patient.
Further, the therapeutic scheme include position to be treated, the therapeutic ultrasound parameter, described therapeutic
The synthetic parameters of the parameter of shock wave and the composite wave.
Based on the above-mentioned technical proposal, the present invention ultrasonic wave generating unit is occurred by combination wave generator therapeutic super
The therapeutic shock wave that sound wave and shock wave generating unit occur is combined into composite wave, and composite wave is applied to position to be treated
It is treated, can make full use of therapeutic ultrasound and the respective biology curative effect of shock wave generating unit in treatment, carry
High therapeutic effect, and reduce the energy used needed for therapeutic ultrasound and therapeutic shock wave respectively, be reduced or avoided compared with
The side effect of the therapeutic ultrasound of high-energy or therapeutic shock wave.
Description of the drawings
Attached drawing described herein is used to provide further understanding of the present invention, and is constituted part of this application, this hair
Bright illustrative embodiments and their description are not constituted improper limitations of the present invention for explaining the present invention.In the accompanying drawings:
Fig. 1 is the block diagram of an embodiment of composite wave therapeutic equipment of the present invention.
Fig. 2 is the block diagram of another embodiment of composite wave therapeutic equipment of the present invention.
Fig. 3 is the block diagram of the another embodiment of composite wave therapeutic equipment of the present invention.
Fig. 4 is the block diagram of an embodiment for the treatment of system of the present invention.
Fig. 5 is the results contrast figure of four groups of fat stem cell proliferation tests.
Fig. 6-Fig. 8 is results contrast figure of four groups of fat stem cell activation experiments under 40 times, 100 times and 200 times.
Fig. 9 (a) and Fig. 9 (b) is respectively the EdU incorporation efficiencies and cell mitogen ratio of four groups of fatty liver cell activation experiments
The comparison figure of rate.
Specific implementation mode
Below by drawings and examples, technical scheme of the present invention will be described in further detail.
As shown in Figure 1, the block diagram of the embodiment for composite wave therapeutic equipment of the present invention.In the present embodiment,
Composite wave therapeutic equipment includes:Ultrasonic wave generating unit 10, shock wave generating unit 20 and combination wave generator 30.Ultrasonic wave is sent out
Raw unit 10 is for occurring therapeutic ultrasound, and to obtain preferable therapeutic effect, therapeutic ultrasound preferably uses low energy
Pulse ultrasonic wave.Shock wave generating unit 20 is for occurring therapeutic shock wave, to obtain preferable therapeutic effect, therapeutic punching
It hits wave and preferably uses low-intensity external knock wave.In order to facilitate use, composite wave therapeutic equipment can have host, and ultrasonic wave is sent out
Raw unit 10 and shock wave generating unit 20 may be provided at the cabinet inside of host.Combination wave generator 30 is sent out with the ultrasonic wave
Raw unit 10 and the shock wave generating unit 20 couple respectively, are used for the therapeutic ultrasound and the therapeutic impact
Wave is combined into composite wave, and the composite wave is applied to position to be treated.Combination wave generator 30 may be provided at the machine of host
Outside case.The interface etc. interacted for user can also be set in the cabinet of host.
The therapeutic ultrasound and shock wave that ultrasonic wave generating unit is occurred by combination wave generator for the present embodiment are sent out
The therapeutic shock wave that raw unit occurs is combined into composite wave, and composite wave is applied to position to be treated and is treated, and is controlling
It can make full use of therapeutic ultrasound and shock wave generating unit respective biology curative effect when treatment, improve therapeutic effect, and
The energy used needed for therapeutic ultrasound and therapeutic shock wave is reduced respectively, and the therapeutic of higher-energy is reduced or avoided
The side effect of ultrasonic wave or therapeutic shock wave.
With reference to figure 5, the therapeutic effect of therapeutic ultrasound and therapeutic shock wave has been mentioned in background technology, and has been mentioned
When the energy rank of ultrasonic wave or shock wave is excessively high, tissue damage may be caused.Inventor is exploring better therapeutic effect
In terms of less side effect, joint sequence application low energy pulses ultrasonic wave and low-intensity external knock wave are used.
In order to carry out the control of effect, fat stem cell is divided into four groups by inventor:Control group (ctrl), low energy pulses
Ultrasonic therapy group (LIPUS), low-intensity extracorporeal impact wave therapy group (Li-ESWT) and low energy pulses ultrasonic wave and low-intensity
External knock wave combination therapy group (US-SW).Wherein, low energy pulses ultrasonic therapy group uses 60mW/cm2It is two minutes, low
Intensity external knock wave group uses 0.02mJ/mm2, 3Hz, 200pulses.Low energy pulses ultrasonic wave and low-intensity extracorporeal shock
Wave combination therapy group uses Li-ESWT0.02mJ/mm2,3Hz, 100pulses first, then gives low energy pulses ultrasonic wave
LIPUS60mW/cm2One minute.
5-chloromethylfluorescein diacetate (abbreviation CFDA) have cell membrane permeability, itself is not
With luminescence.It, can be by intracytoplasmic esterase catalyzed generation after entering living cells by passively transporting penetration cell film
Fluoresceincarboxylic acid succinimide ester (carboxyfluorescein succinimidyl ester, CFSE), the latter Ke Fa is strong
Strong green fluorescence, is unable to penetration cell film, can be intact be retained in intracellular.Using the work in the CFDA label culture dishes of 10uM
Cell.Then fluorescence microscope photograph and image analysis.In conjunction with image shown in fig. 5 and active cell/every high power field of view
(Alive cell/HPF), it can be seen that compared to control group, low energy pulses ultrasonic therapy group and low-intensity extracorporeal shock
Wave group can be obviously promoted cell Proliferation, improve cell quantity.And be respectively adopted the low energy pulses ultrasonic wave of half amount with
Low-intensity external knock wave combination therapy group then can reach stronger effect, embody therapeutic ultrasound and therapeutic shock wave
Synergistic effect.Application energy based on lower ultrasonic wave and shock wave, it is less to the damage of tissue when being used in combination, and
Stronger therapeutic effect can also be reached.
It is external with low-intensity to monitor low energy pulses ultrasonic wave using EdU incorporation experiments below with reference to Fig. 6-Fig. 9 (b)
Shock wave detects the expression of cell division marker H3P to the activation of stem cell.In order to carry out the control of effect, send out
Fat stem cell is divided into four groups by a person of good sense:Control group (ctrl), low energy pulses ultrasonic therapy group (LIPUS), low-intensity body
Combined use of ESWL treatment group (Li-ESWT) and low energy pulses ultrasonic wave and low-intensity external knock wave combination therapy group (US-SW).
Wherein, low energy pulses ultrasonic therapy group uses 60mW/cm2Two minutes, low-intensity external knock wave group used 0.02mJ/
mm2, 3Hz, 200pulses.Low energy pulses ultrasonic wave uses Li-ESWT first with low-intensity external knock wave combination therapy group
Then 0.02mJ/mm2,3Hz, 100pulses give low energy pulses ultrasonic wave LIPUS 60mW/cm2One minute.It is treating
Each group is added 10uM EdU and is incubated 6 hours immediately afterwards, then replaces regular growth culture solution.The table of EdU is detected after 24 hours
Up to the expression with H3P.
In conjunction with the image of Fig. 6-different multiples shown in Fig. 8, it can be seen that compared to control group, low energy pulses ultrasonic wave
Treatment group and low-intensity external knock wave group can significantly increase the incorporation efficiency of EdU, this shows both promote to do
S phases DNA of cell synthesize.And the low energy pulses ultrasonic wave and low-intensity external knock wave combination therapy group of half amount is respectively adopted
Stronger effect is then can reach, the synergistic effect of therapeutic ultrasound and therapeutic shock wave is embodied.In addition, either low energy
Measure pulse ultrasonic wave treatment group and low-intensity external knock wave group, be still respectively adopted the low energy pulses ultrasonic wave of half amount with it is low
Intensity external knock wave combination therapy group then can highly significant raising stem cell mitosis.Based on lower ultrasonic wave
It is less to the damage of tissue when being used in combination with the application energy of shock wave, but also stronger therapeutic effect can be reached.
By the body stimulation mode of above-mentioned combination therapy group, the regenerative healing of tissue can be promoted, can be used for a variety of diseases
The therapeutic process, such as male erectile dysfunction, gatism or women's Recovery etc. of disease.
In the above-described embodiments, the ultrasonic frequency range of low energy pulses ultrasonic wave is preferably 1~2MHz, and the sound intensity is ranging from
0.05~3W/cm2.It is highly preferred that the ultrasonic frequency range of low energy pulses ultrasonic wave is 1.5~1.7MHz.Such low energy
Pulse ultrasonic wave can obtain relatively better therapeutic effect with lower energy, and reduce the damage to tissue.Low-intensity
The frequency range of external knock wave is preferably 1~6Hz, and energy range is 0.01~0.7mJ/mm2.Low-intensity external supersonic in this way
Wave can obtain relatively better therapeutic effect with lower energy, and reduce the damage to tissue.
With reference to figure 1, controlling along sequential combination can be used when treating therapentic part application composite wave in combination wave generator 30
Treatment uses shock wave and treatment to use ultrasonic wave as composite wave.In further embodiments, treatment shock wave and treatment ultrasound
Wave can need simultaneously according to treatment or be applied with multiple alternation method or in different order.
As shown in Fig. 2, the block diagram of another embodiment for composite wave therapeutic equipment of the present invention.With a upper embodiment
It compares, composite wave therapeutic equipment further includes controller 60.Controller 60 can respectively with the ultrasonic wave generating unit 10, the punching
Wave generating unit 20 is hit to connect with 30 signal of the combination wave generator, for respectively to the parameter of the therapeutic ultrasound,
The parameter of the therapeutic shock wave or the synthetic parameters of the composite wave are adjusted.Here the parameter of therapeutic ultrasound can
Include the type etc. of ultrasonic frequency range, sound intensity range and therapeutic ultrasound.The parameter of therapeutic shock wave may include frequency
The type etc. of rate range, energy range and therapeutic shock wave.The synthetic parameters of composite wave may include therapeutic ultrasound institute
The application sequential relationship etc. of the duration of application, the umber of pulse of therapeutic shock wave and two kinds of waves.
In order to which the type to therapeutic ultrasound is adjusted, in some embodiments, ultrasonic wave generating unit 10 may be used also
It including the first adjustment lens, is connect with 60 signal of the controller, for adjusting the ultrasonic wave generating unit 10 to described group
The type for the therapeutic ultrasound that multiplex generator 30 exports.Similarly, in order to which the type to therapeutic shock wave is adjusted,
In some embodiments, shock wave generating unit 20 can also include second adjustment lens, be connect with 60 signal of the controller, use
In the type for adjusting the therapeutic shock wave that the shock wave generating unit 20 is exported to the combination wave generator 30.Here
Type can include one kind in plane wave, dispersive wave, focus wave and semi-focusing wave according to the type of focusing of wave.
The wave of these types of type is form of expression when wave is launched, and is mainly distinguished from the density of wave.Wherein,
Plane wave is exactly that all wave beams are all parallel, and out-focus does not also dissipate;Dispersive wave is exactly wave beam into divergent shape, wave density ratio
Plane wave is small;The wave beam of focus wave can converge in a focus, and energy is more concentrated, Bomi degree bigger;Semi-focusing wave is from Bomi
It is the wave between focus wave and plane wave from degree, comparatively Bomi degree also therebetween, it is small to be more than plane wave
In focus wave.Acoustic lens can be used in the first adjustment lens and second adjustment lens, to change the focusing journey of ultrasonic wave or shock wave
Degree changes the degree of energy concentration by changing different focus types, and then obtains different therapeutic effects.
Can also include more in composite wave therapeutic equipment in order to facilitate user using the composite wave therapeutic equipment of the present invention
Media play unit 70.The multi-media player unit 70 is connect with 60 signal of the controller, for play auxiliary use and/or
The audio/video information of auxiliary treatment.Multi-media player unit 70 can be connect with composite wave therapeutic equipment main-machine communication it is upper
Machine can also be display and sound card on composite wave therapeutic equipment host etc. or wearable with the earphone etc. in account.
Multi-media player unit 70 can inform the occupation mode of user's composite wave therapeutic equipment in a manner of audio and video, and provide one
It can be with the music of auxiliary treatment, picture or white noise etc. when a little treatments.
As shown in figure 3, the block diagram of the another embodiment for composite wave therapeutic equipment of the present invention.Implement with each before
Example is compared, and the composite wave therapeutic equipment of the present embodiment can also include treatment probe 40 and probe adjusting mechanism 50.Composite wave is sent out
Raw device 30 may be provided at the top of the treatment probe 40, the probe adjusting mechanism 50 and the treatment 40 operability of probe
Ground couples.The hand-holdable treatment probe 40 of user, is directed at position to be treated by its top and treats, or pass through adjustment machine of popping one's head in
Structure 50 adjusts the pose of the treatment probe 40, i.e. movement position and launch angle, so that treatment probe 40 can be more accurate
Really, it is more easily directed at therapentic part, to obtain better therapeutic effect.
Probe adjusting mechanism 50 includes mechanical arm, the end treated probe 40 and be mounted on the mechanical arm, described group
Multiplex therapeutic equipment further includes controller 60, and the controller 60 connects with the mechanical arm and the treatment 40 signals of probe respectively
It connects, the treatment probe 40 is driven to be moved to position to be treated for controlling the mechanical arm.Controller 60 can be according to advance
The instruction of setting is moved from the instruction control machinery arm of user local or network side, and drives treatment probe 40 multiple
It is moved between position to be treated.
Said combination wave treatment equipment can offline be used in subscriber household or medical space, can also be reached the standard grade and network
Cloud platform carries out information exchange.As shown in figure 4, the block diagram of the embodiment for treatment system of the present invention.In this implementation
In example, treatment system includes aforementioned any composite wave therapeutic equipment embodiment and network cloud platform 80.Network cloud platform 80 with
The composite wave therapeutic equipment communication connection, for providing therapeutic scheme to the composite wave therapeutic equipment.With reference to figure 4, one
In a little embodiments, network cloud platform 80 can specifically include:Bill under information memory cell 81, scheme storage unit 82 and scheme
Member 83.Wherein, information memory cell 81 is used to store the identity identification information and medical record information of patient.Scheme storage unit 82 is used
In storage corresponding to various disease and/or the therapeutic scheme of different patients.Therapeutic scheme may include position to be treated, described control
The parameter of the property treated ultrasonic wave, the synthetic parameters of the parameter and the composite wave of the therapeutic shock wave.Scheme issuance unit 83
For after the identity identification information for confirming patient, being asked according to the download from patient terminal, to associated with the patient
Composite wave therapeutic equipment issues corresponding therapeutic scheme.Patient terminal can make the movement or fixed terminal that patient oneself uses,
The operable interface on composite wave therapeutic equipment can also be provided in.
Finally it should be noted that:The above embodiments are merely illustrative of the technical scheme of the present invention and are not intended to be limiting thereof;To the greatest extent
The present invention is described in detail with reference to preferred embodiments for pipe, those of ordinary skills in the art should understand that:Still
It can modify to the specific implementation mode of the present invention or equivalent replacement is carried out to some technical characteristics;Without departing from this hair
The spirit of bright technical solution should all cover within the scope of the technical scheme claimed by the invention.
Claims (17)
1. a kind of composite wave therapeutic equipment, which is characterized in that including:
Ultrasonic wave generating unit (10), for therapeutic ultrasound to occur;
Shock wave generating unit (20), for therapeutic shock wave to occur;With
Combination wave generator (30), with the ultrasonic wave generating unit (10) and the shock wave generating unit (20) difference coupling
It closes, for the therapeutic ultrasound and the therapeutic shock wave to be combined into composite wave, and the composite wave is applied to
Position to be treated.
2. composite wave therapeutic equipment according to claim 1, which is characterized in that the therapeutic ultrasound is low energy arteries and veins
Rush ultrasonic wave.
3. composite wave therapeutic equipment according to claim 2, which is characterized in that the ultrasound of the low energy pulses ultrasonic wave
Frequency range is 1~2MHz, the sound intensity ranging from 0.05~3W/cm2。
4. composite wave therapeutic equipment according to claim 3, which is characterized in that the ultrasound of the low energy pulses ultrasonic wave
Frequency range is 1.5~1.7MHz.
5. composite wave therapeutic equipment according to claim 1, which is characterized in that the therapeutic shock wave is low-intensity body
Combined use of ESWL.
6. composite wave therapeutic equipment according to claim 5, which is characterized in that the frequency of the low-intensity external knock wave
Ranging from 1~6Hz, energy range are 0.01~0.7mJ/mm2。
7. composite wave therapeutic equipment according to claim 1, which is characterized in that the composite wave is controlling along sequential combination
Treatment shock wave and treatment ultrasonic wave.
8. composite wave therapeutic equipment according to claim 7, which is characterized in that further include:
Controller (60), respectively with the ultrasonic wave generating unit (10), the shock wave generating unit (20) and the combination
Wave producer (30) signal connects, for respectively to the parameter of the parameter of the therapeutic ultrasound, the therapeutic shock wave
Or the synthetic parameters of the composite wave are adjusted.
9. composite wave therapeutic equipment according to claim 1, which is characterized in that further include that treatment probe (40) and probe are adjusted
Complete machine structure (50), combination wave generator (30) setting is in the top of the treatment probe (40), the probe adjusting mechanism
(50) it is operably coupled with treatment probe (40), the pose for adjusting the treatment probe (40).
10. composite wave therapeutic equipment according to claim 9, which is characterized in that the probe adjusting mechanism (50) includes
Mechanical arm, the treatment probe (40) are mounted on the end of the mechanical arm, and the composite wave therapeutic equipment further includes controller
(60), the controller (60) connect with the mechanical arm and treatment probe (40) signal respectively, for controlling the machine
Tool arm drives the treatment probe (40) to be moved to position to be treated.
11. composite wave therapeutic equipment according to claim 8, which is characterized in that the ultrasonic wave generating unit (10) is also
It including the first adjustment lens, is connect with the controller (60) signal, for adjusting the ultrasonic wave generating unit (10) to institute
State the type of the therapeutic ultrasound of combination wave generator (30) output.
12. composite wave therapeutic equipment according to claim 8, which is characterized in that the shock wave generating unit (20) is also
It including second adjustment lens, is connect with the controller (60) signal, for adjusting the shock wave generating unit (20) to institute
State the type of the therapeutic shock wave of combination wave generator (30) output.
13. composite wave therapeutic equipment according to claim 11 or 12, which is characterized in that the type include plane wave,
One kind in dispersive wave, focus wave and semi-focusing wave.
14. composite wave therapeutic equipment according to claim 8, which is characterized in that further include:
Multi-media player unit (70) is connect with the controller (60) signal, for playing auxiliary use and/or auxiliary treatment
Audio/video information.
15. a kind for the treatment of system, including:
Any composite wave therapeutic equipment of claim 1~14;With
Network cloud platform (80) is communicated to connect with the composite wave therapeutic equipment, for being provided to the composite wave therapeutic equipment
Therapeutic scheme.
16. treatment system according to claim 15, which is characterized in that the network cloud platform (80) includes:
Information memory cell (81), identity identification information and medical record information for storing patient;
Scheme storage unit (82), for storing the therapeutic scheme corresponding to various disease and/or different patients;
Scheme issuance unit (83), for after the identity identification information for confirming patient, being asked according to the download from patient terminal
It asks, corresponding therapeutic scheme is issued to the associated composite wave therapeutic equipment of the patient.
17. treatment system according to claim 16, which is characterized in that the therapeutic scheme includes position to be treated, institute
State the synthetic parameters of the parameter of therapeutic ultrasound, the parameter and the composite wave of the therapeutic shock wave.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020011130A1 (en) * | 2018-07-09 | 2020-01-16 | 北京万孛力医疗器械有限公司 | Combination wave-based therapeutic apparatus and system |
WO2020011125A1 (en) * | 2018-07-09 | 2020-01-16 | 北京万孛力医疗器械有限公司 | Asthenozoospermia treatment device |
EP3682822A1 (en) * | 2019-01-18 | 2020-07-22 | Storz Medical AG | Combined shockwave and ultrasound source |
CN114259279A (en) * | 2021-12-22 | 2022-04-01 | 深圳市慧康精密仪器有限公司 | Therapeutic device capable of generating shock waves or ultrasonic waves |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4976255A (en) * | 1988-08-17 | 1990-12-11 | Siemens Aktiengesellschaft | Apparatus for extracorporeal lithotripsy using shock waves and therapeutic ultrasound |
CN2514847Y (en) * | 1999-09-28 | 2002-10-09 | 玉骑 | Composite pulse generator for electric pulse beautifying device |
US20060100552A1 (en) * | 2004-10-22 | 2006-05-11 | Reiner Schultheiss | Therapeutic treatment for infertility or impotency |
CN101437459A (en) * | 2006-05-05 | 2009-05-20 | 西门子公司 | Shock wave head for a shock wave treatment apparatus and method for the fragmentation of and for controlling the fragmentation of a fragmentation object arranged in an object under investigation |
KR20090117208A (en) * | 2008-05-09 | 2009-11-12 | 주식회사 에이치엔티메디칼 | Shock wave and ultrasound wave integrated therapy device |
US20110144544A1 (en) * | 2009-12-15 | 2011-06-16 | General Electric Company | Ultrasound transducer assembly and methods of using |
CN104138638A (en) * | 2014-07-15 | 2014-11-12 | 深圳市慧康精密仪器有限公司 | Erectile dysfunction impact wave therapeutic instrument |
US20150258352A1 (en) * | 2014-03-12 | 2015-09-17 | Kuang-Wei Lin | Frequency compounding ultrasound pulses for imaging and therapy |
CN105726190A (en) * | 2014-12-12 | 2016-07-06 | 北京东方百奥医药开发有限公司 | Pulse ultrasound treatment equipment for male erectile dysfunction |
CN107301321A (en) * | 2017-07-14 | 2017-10-27 | 安徽荣旭信息科技有限公司 | A kind of Multifunctional medical information network system |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7048699B2 (en) * | 2001-09-12 | 2006-05-23 | Moshe Ein-Gal | Non-cylindrical acoustic wave device |
DE202011110916U1 (en) * | 2010-08-27 | 2017-04-26 | Sienna Biopharmaceuticals, Inc. | Topical cosmetic or pharmaceutical composition |
CN205885491U (en) * | 2016-06-21 | 2017-01-18 | 深圳市慧康精密仪器有限公司 | External heart shock wave therapy apparatus |
CN108720897B (en) * | 2018-07-09 | 2023-12-05 | 北京万孛力医疗器械有限公司 | Combination wave therapy device and therapy system |
-
2018
- 2018-07-09 CN CN201810741583.1A patent/CN108720897B/en active Active
-
2019
- 2019-07-08 WO PCT/CN2019/095101 patent/WO2020011130A1/en active Application Filing
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4976255A (en) * | 1988-08-17 | 1990-12-11 | Siemens Aktiengesellschaft | Apparatus for extracorporeal lithotripsy using shock waves and therapeutic ultrasound |
CN2514847Y (en) * | 1999-09-28 | 2002-10-09 | 玉骑 | Composite pulse generator for electric pulse beautifying device |
US20060100552A1 (en) * | 2004-10-22 | 2006-05-11 | Reiner Schultheiss | Therapeutic treatment for infertility or impotency |
CN101437459A (en) * | 2006-05-05 | 2009-05-20 | 西门子公司 | Shock wave head for a shock wave treatment apparatus and method for the fragmentation of and for controlling the fragmentation of a fragmentation object arranged in an object under investigation |
KR20090117208A (en) * | 2008-05-09 | 2009-11-12 | 주식회사 에이치엔티메디칼 | Shock wave and ultrasound wave integrated therapy device |
US20110144544A1 (en) * | 2009-12-15 | 2011-06-16 | General Electric Company | Ultrasound transducer assembly and methods of using |
US20150258352A1 (en) * | 2014-03-12 | 2015-09-17 | Kuang-Wei Lin | Frequency compounding ultrasound pulses for imaging and therapy |
CN104138638A (en) * | 2014-07-15 | 2014-11-12 | 深圳市慧康精密仪器有限公司 | Erectile dysfunction impact wave therapeutic instrument |
CN105726190A (en) * | 2014-12-12 | 2016-07-06 | 北京东方百奥医药开发有限公司 | Pulse ultrasound treatment equipment for male erectile dysfunction |
CN107301321A (en) * | 2017-07-14 | 2017-10-27 | 安徽荣旭信息科技有限公司 | A kind of Multifunctional medical information network system |
Non-Patent Citations (2)
Title |
---|
辛钟成等: "Clinical applications of low-intensity pulsed ultrasound and its potential role in urology", TRANSLATIONAL ANDROLOGY AND UROLOGY, vol. 5, no. 2, pages 255 - 266 * |
辛钟成等: "低能量体外冲击波治疗的临床应用进展", 北京大学学报( 医学版), vol. 45, no. 4, pages 657 - 660 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020011130A1 (en) * | 2018-07-09 | 2020-01-16 | 北京万孛力医疗器械有限公司 | Combination wave-based therapeutic apparatus and system |
WO2020011125A1 (en) * | 2018-07-09 | 2020-01-16 | 北京万孛力医疗器械有限公司 | Asthenozoospermia treatment device |
EP3682822A1 (en) * | 2019-01-18 | 2020-07-22 | Storz Medical AG | Combined shockwave and ultrasound source |
WO2020148433A1 (en) * | 2019-01-18 | 2020-07-23 | Storz Medical Ag | Combined shockwave and ultrasound source |
CN114259279A (en) * | 2021-12-22 | 2022-04-01 | 深圳市慧康精密仪器有限公司 | Therapeutic device capable of generating shock waves or ultrasonic waves |
CN114259279B (en) * | 2021-12-22 | 2024-03-19 | 深圳市慧康精密仪器有限公司 | Therapeutic device capable of generating shock wave or ultrasonic wave |
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