CN108714122A - A kind of permanent tooth emulsifiable paste and preparation method thereof containing rhizoma nardostachyos - Google Patents

A kind of permanent tooth emulsifiable paste and preparation method thereof containing rhizoma nardostachyos Download PDF

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CN108714122A
CN108714122A CN201810558096.1A CN201810558096A CN108714122A CN 108714122 A CN108714122 A CN 108714122A CN 201810558096 A CN201810558096 A CN 201810558096A CN 108714122 A CN108714122 A CN 108714122A
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emulsifiable paste
rhizoma nardostachyos
percentage
radix
lotion
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林承伟
袁涛
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K8/34—Alcohols
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns

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Abstract

The present invention provides a kind of permanent tooth emulsifiable paste containing rhizoma nardostachyos, contain the drug ingedient being made of Radix Notoginseng, Radix Et Rhizoma Nardostachyos extract, borneol and basil oil in the emulsifiable paste, the percentage that wherein Radix Notoginseng accounts for emulsifiable paste lotion weight in terms of notoginseng total saponin is 0.05~0.1%%, the percentage that Radix Et Rhizoma Nardostachyos extract accounts for emulsifiable paste lotion weight is 0.5~1%, Radix Et Rhizoma Nardostachyos extract is petroleum ether extract of the rhizoma nardostachyos after alcohol reflux extracts, the percentage that borneol accounts for emulsifiable paste lotion weight is 0.5~1%, and the percentage that basil oil accounts for emulsifiable paste lotion weight in terms of eugenol is 0.5~1%；Also contain rubbing agent in the lotion of emulsifiable paste, the rubbing agent is MULTILAYER COMPOSITE silica dioxide granule, and the percentage for accounting for emulsifiable paste lotion weight is 30~45%.The present invention also provides the preparation method of above-mentioned emulsifiable paste simultaneously.The present invention solves the problems, such as that rhizoma nardostachyos component and effect plays difference and traditional Chinese medicinal components type is complicated, while having permanent tooth shield gum, deodorization and sterilization effect.

Description

A kind of permanent tooth emulsifiable paste and preparation method thereof containing rhizoma nardostachyos
Technical field
The present invention relates to a kind of permanent tooth emulsifiable paste, especially a kind of permanent tooth emulsifiable paste and preparation method thereof containing rhizoma nardostachyos.
Background technology
Emulsifiable paste is common cleaning supplies in daily life, there is very long history.With the continuous hair of science and technology Exhibition, technological equipment continuously improve and it is perfect, various types of emulsifiable pastes are come out one after another, and the quality and grade of product is continuously improved, Present emulsifiable paste kind develops into great variety of goods, vdiverse in function by single clean type emulsifiable paste, a brands up to a hundred it is multi-functional Type emulsifiable paste meets the needs of the different levels level of consumption.
There are many type in China market, and wherein Chinese herbal medicine emulsifiable paste is become with advantages such as its green nature, safety, effect uniquenesses The bright spot of emulsifiable paste industry also appeared in market in recent years wherein containing the one kind of the emulsifiable paste of rhizoma nardostachyos as Chinese herbal medicine emulsifiable paste.Example As the patent document of Publication No. CN103405365A, CN105769726A, CN105250193A, CN1633970A disclose A kind of Chinese medicine preparation emulsifiable paste also all contains rhizoma nardostachyos in ingredient, but the traditional Chinese medicine ingredients contained in above-mentioned patented product exist Ten kinds or more, some is even more than 20 kinds, and rhizoma nardostachyos therein is not used as main ingredient and plays its effect.It is understood that When brushing teeth, emulsifiable paste can only stop two minutes in the oral cavity, and the emulsifiable paste weight used every time is about 1.5g, since existing emulsifiable paste produces Traditional Chinese medicinal components type is excessive in product and rhizoma nardostachyos is not key component, therefore the rhizoma nardostachyos ingredient in existing emulsifiable paste is when actually brushing teeth The pharmacologic action that can be generated is extremely limited.To sum up, how on the decrease in the case of medicine constituent species ensure rhizoma nardostachyos at Point the effect of playing stably property become current the art will the problem that there is an urgent need for capture.
Invention content
For overcome the deficiencies in the prior art, the present invention provides a kind of permanent tooth emulsifiable paste containing rhizoma nardostachyos and its preparation side Method solves the problems, such as that rhizoma nardostachyos component and effect plays difference in the prior art and traditional Chinese medicinal components type is complicated, while there is sterilization to remove Smelly effect.
The technical solution adopted by the present invention to solve the technical problems is：
Present invention firstly provides the permanent tooth emulsifiable paste that a kind of emulsifiable paste contains rhizoma nardostachyos, contain drug ingedient in the emulsifiable paste, it is described Drug ingedient is made of Radix Notoginseng, Radix Et Rhizoma Nardostachyos extract, borneol and basil oil, wherein the Radix Notoginseng accounts for institute in terms of arasaponin The percentage for stating emulsifiable paste lotion weight is 0.05~0.1%, and the Radix Et Rhizoma Nardostachyos extract accounts for the percentage of the emulsifiable paste lotion weight It is 0.5~1%, the Radix Et Rhizoma Nardostachyos extract is petroleum ether extract of the rhizoma nardostachyos after alcohol reflux extracts, and the borneol accounts for described The percentage of emulsifiable paste lotion weight is 0.5~1%, and the basil oil accounts for the hundred of the emulsifiable paste lotion weight in terms of eugenol Divide than being 0.5~1%；Also containing rubbing agent in the lotion of the emulsifiable paste, the rubbing agent is MULTILAYER COMPOSITE silica dioxide granule, The percentage for accounting for the emulsifiable paste lotion weight is 30~45%.
Preferably, wetting agent, adhesive and foaming agent are also contained in the lotion of the emulsifiable paste.
Preferably, the wetting agent is one or both of glycerine, sorbierite, propylene glycol, accounts for the emulsifiable paste lotion weight The percentage of amount is 20~30%；Described adhesive is hydroxyethyl cellulose, and the percentage for accounting for the emulsifiable paste lotion weight is 0.6 ~2.5%；The foaming agent is lauryl sodium sulfate, and the percentage for accounting for the emulsifiable paste lotion weight is 1.6~2.5%.
The present invention also provides the preparation methods that a kind of emulsifiable paste contains the permanent tooth emulsifiable paste of rhizoma nardostachyos, include the following steps：
S1 weighs 3~8g Silica microparticles, adds it in the absolute ethyl alcohol of 120~150ml, is added simultaneously 1.2~1.8g cetyl trimethylammonium bromides, ultrasonic disperse 30~45 minutes, resulting dispersion system；
The urea of 0.9~1.6g is added in S2 under stirring into above-mentioned dispersion, while being added 20~30ml's Deionized water is placed in 40~50 DEG C of water bath with thermostatic control and keeps the temperature；
S3 addition 0.7~1.1g tannic acids in the case where speed is 600~800 revs/min of stirring condition, stirring 5~10 minutes, so It is 9~9.5 that ammonium hydroxide is added afterwards and adjusts pH value of solution, obtains mixing suspension；
The polyvinylpyrrolidone of 2.5~6g is uniformly mixed by S4 with the ethyl orthosilicate of 20~30ml, must mix dropwise addition This is mixed dropping liquid and is slowly dropped in the mixing suspension, continues to be stirred to react 4~6 hours by liquid, separating, washing, Dry SiO2Core@SiO2Shell micron particles；
S5 is by SiO obtained2Core@SiO2Shell micron particles are added to the hydrofluoric acid solution that volumetric concentration is 0.1~0.2% In, wherein SiO2Core@SiO2The weight ratio of shell micron particles and the hydrofluoric acid solution is 2~3:10, etch 10-15 minutes with To SiO2Shell carries out pitting, and separating, washing, drying obtains SiO2The porous SiO of core@2Shell micron particles；
S6 takes the SiO2The porous SiO of core@2Shell 8~10g of micron particles, is added in the absolute ethyl alcohol of 20~35ml, so 0.1~0.2g azones and the Radix Et Rhizoma Nardostachyos extract of 8~12g are added afterwards, is protected under the conditions of 40~50 DEG C of waters bath with thermostatic control after stirring evenly It holds 1~2 hour；
Cetyl trimethylammonium bromide 5~8ml of aqueous solution that mass concentration is 5%, ultrasound are added under S7 stirrings Dispersion 10 minutes, is then slowly added dropwise the ethyl orthosilicate of 25~35ml, while it is 9~10 that ammonium hydroxide, which is added, to adjust pH value of solution, drop Add finish after the reaction was continued 3~4 hours, separating, washing, drying obtains the MULTILAYER COMPOSITE that internal penetration is coated with Radix Et Rhizoma Nardostachyos extract Silica dioxide granule, the mass ratio of Radix Et Rhizoma Nardostachyos extract and silica is 1 in this MULTILAYER COMPOSITE silica dioxide granule:20~30；
S8 takes wetting agent and adhesive to be placed in container, and stirring makes it be uniformly mixed, and a certain amount of Radix Et Rhizoma Nardostachyos extract is being stirred It mixes and is added slowly under state in the mixture of wetting agent and adhesive, stirring obtains transparent colloid in 3~5 minutes；
S9 takes the MULTILAYER COMPOSITE silica dioxide granule and Radix Notoginseng, borneol and basil oil to be uniformly mixed, and is then added Into the transparent colloid, stirring adds foaming agent, stirs evenly to uniform paste is become；
It is filling after S10 vacuum outgas.
The positive effect of the present invention：The core-shell silica particle with rough surface has been made in the present invention first, with Convenient for carrying out surface borrosion hole to this nucleocapsid particles and then obtaining the porous micron particles of shell, to its borrosion hole internal penetration rhizoma nardostachyos After extract, recycles silicon dioxide layer to be coated, obtain three layers that unique internal penetration is coated with Radix Et Rhizoma Nardostachyos extract Silica dioxide granule, this multi-layer silica dioxide type rubbing agent has stronger dirt-removing power, while can effectively reduce to tooth Caused by wear, and using the method for the invention prepare emulsifiable paste when, stratiform silica is easy by the friction with tooth Breakage occurs to fall off, internal Radix Et Rhizoma Nardostachyos extract plays a role jointly with the active ingredient being added directly into emulsifiable paste lotion, It is remarkably improved the practical pharmacologic action of traditional Chinese medicine ingredients especially rhizoma nardostachyos, it is at the same time, most of sweet before rubbing agent friction is damaged Loose extract is implied in inside rubbing agent particle, can effectively avoid the loss of Active Components of Nardostachys chinensis when brushing teeth, preferably to send out Wave its effect.The present invention is aided with borneol, basil oil only using rhizoma nardostachyos, Radix Notoginseng as main ingredient, and traditional Chinese medicinal components type is extremely simple, Wherein rhizoma nardostachyos has the work(of regulating qi-flowing for relieving pain, calm maincenter, work(of the Radix Notoginseng with dissipate stasis of blood hemostasis, detumescence ding-tong to be divided into this two kinds of groups The effect of main ingredient, then the effect of be aided with the clearing heat and detoxicating of borneol, erosion prevention and muscle growing, the dispelling wind and eliminating pain of basil oil, antisepsis and sterilization, It is subject to the special existence of Radix Et Rhizoma Nardostachyos extract, good synergistic effect can be generated between each component, product of the present invention has strong Root permanent tooth, clearing away heat to stop bleeding, the effect of cleaning gum, strong tooth shield gum, deodorization and sterilization and fresh breath, go out tooth mobility, gum Blood, gum swelling etc. have remarkable result.
Specific implementation mode
Below to a preferred embodiment of the present invention will be described in detail.
Embodiment 1
The preferred embodiment of the present invention 1 provides a kind of permanent tooth emulsifiable paste containing rhizoma nardostachyos, contains drug ingedient in the emulsifiable paste, institute It states drug ingedient to be made of Radix Notoginseng, Radix Et Rhizoma Nardostachyos extract, borneol and basil oil, wherein the Radix Notoginseng is accounted in terms of arasaponin The percentage of the emulsifiable paste lotion weight is 0.05%, and the percentage that the Radix Et Rhizoma Nardostachyos extract accounts for the emulsifiable paste lotion weight is 1%, the Radix Et Rhizoma Nardostachyos extract is petroleum ether extract of the rhizoma nardostachyos after alcohol reflux extracts, and the borneol accounts for the emulsifiable paste lotion The percentage of weight is 1.0%, and the percentage that the basil oil accounts for the emulsifiable paste lotion weight in terms of eugenol is 0.5%；Also contain rubbing agent in the lotion of the emulsifiable paste, the rubbing agent is MULTILAYER COMPOSITE silica dioxide granule, accounts for the breast The percentage of cream lotion weight is 35%.
Also contain wetting agent, adhesive and foaming agent in the lotion of the emulsifiable paste.
The wetting agent is glycerine, and the percentage for accounting for the emulsifiable paste lotion weight is 21%；Described adhesive is ethoxy Cellulose, the percentage for accounting for the emulsifiable paste lotion weight are 0.9%；The foaming agent is lauryl sodium sulfate, accounts for the breast The percentage of cream lotion weight is 1.7%.
Embodiment 2
The preferred embodiment of the present invention 2 provides a kind of permanent tooth emulsifiable paste containing rhizoma nardostachyos, contains drug ingedient in the emulsifiable paste, institute It states drug ingedient to be made of Radix Notoginseng, Radix Et Rhizoma Nardostachyos extract, borneol and basil oil, wherein the Radix Notoginseng is accounted in terms of notoginseng total saponin The percentage of the emulsifiable paste lotion weight is 0.75%, and the percentage that the Radix Et Rhizoma Nardostachyos extract accounts for the emulsifiable paste lotion weight is 0.65%, the Radix Et Rhizoma Nardostachyos extract is petroleum ether extract of the rhizoma nardostachyos after alcohol reflux extracts, and the borneol accounts for the emulsifiable paste The percentage of lotion weight is 0.8%, and the percentage that the basil oil accounts for the emulsifiable paste lotion weight in terms of eugenol is 0.8%；Also contain rubbing agent in the lotion of the emulsifiable paste, the rubbing agent is MULTILAYER COMPOSITE silica dioxide granule, accounts for the breast The percentage of cream lotion weight is 38%.
Also contain wetting agent, adhesive and foaming agent in the lotion of the emulsifiable paste.
The wetting agent is sorbierite and propylene glycol mixture, and the percentage for accounting for the emulsifiable paste lotion weight is 26%；Institute It is hydroxyethyl cellulose to state adhesive, and the percentage for accounting for the emulsifiable paste lotion weight is 1.3%；The foaming agent is dodecyl Sodium sulphate, the percentage for accounting for the emulsifiable paste lotion weight are 2.0%.
Embodiment 3
The preferred embodiment of the present invention 3 provides a kind of permanent tooth emulsifiable paste containing rhizoma nardostachyos, contains drug ingedient in the emulsifiable paste, institute It states drug ingedient to be made of Radix Notoginseng, Radix Et Rhizoma Nardostachyos extract, borneol and basil oil, wherein the Radix Notoginseng is accounted in terms of notoginseng total saponin The percentage of the emulsifiable paste lotion weight is 0.09%, and the percentage that the Radix Et Rhizoma Nardostachyos extract accounts for the emulsifiable paste lotion weight is 0.85%, the Radix Et Rhizoma Nardostachyos extract is petroleum ether extract of the rhizoma nardostachyos after alcohol reflux extracts, and the borneol accounts for the emulsifiable paste The percentage of lotion weight is 0.75%, and the percentage that the basil oil accounts for the emulsifiable paste lotion weight in terms of eugenol is 0.85%；Also contain rubbing agent in the lotion of the emulsifiable paste, the rubbing agent is MULTILAYER COMPOSITE silica dioxide granule, accounts for the breast The percentage of cream lotion weight is 42%.
Also contain wetting agent, adhesive and foaming agent in the lotion of the emulsifiable paste.
The wetting agent is propylene glycol, and the percentage for accounting for the emulsifiable paste lotion weight is 28%；Described adhesive is hydroxyl second Base cellulose, the percentage for accounting for the emulsifiable paste lotion weight are 2.1%；The foaming agent is lauryl sodium sulfate, is accounted for described The percentage of emulsifiable paste lotion weight is 2.1%.
Embodiment 4
The preferred embodiment of the present invention 4 provides a kind of permanent tooth emulsifiable paste containing rhizoma nardostachyos, contains drug ingedient in the emulsifiable paste, institute It states drug ingedient to be made of Radix Notoginseng, Radix Et Rhizoma Nardostachyos extract, borneol and basil oil, wherein the Radix Notoginseng is accounted in terms of notoginseng total saponin The percentage of the emulsifiable paste lotion weight is 0.1%, and the percentage that the Radix Et Rhizoma Nardostachyos extract accounts for the emulsifiable paste lotion weight is 1%, the Radix Et Rhizoma Nardostachyos extract is petroleum ether extract of the rhizoma nardostachyos after alcohol reflux extracts, and the borneol accounts for the emulsifiable paste lotion The percentage of weight is 1%, and the percentage that the basil oil accounts for the emulsifiable paste lotion weight in terms of eugenol is 1%；Institute It states and also contains rubbing agent in the lotion of emulsifiable paste, the rubbing agent is MULTILAYER COMPOSITE silica dioxide granule, accounts for the emulsifiable paste lotion weight The percentage of amount is 44%.
Also contain wetting agent, adhesive and foaming agent in the lotion of the emulsifiable paste.
The wetting agent is sorbierite, and the percentage for accounting for the emulsifiable paste lotion weight is 29%；Described adhesive is hydroxyl second Base cellulose, the percentage for accounting for the emulsifiable paste lotion weight are 1.6%；The foaming agent is lauryl sodium sulfate, is accounted for described The percentage of emulsifiable paste lotion weight is 2.1%.
Embodiment 5
The preferred embodiment of the present invention 5 provides a kind of preparation method of the above-mentioned permanent tooth emulsifiable paste containing rhizoma nardostachyos, including walks as follows Suddenly：
S1 weighs 4g Silica microparticles, adds it in the absolute ethyl alcohol of 120ml, while 1.3g 16 is added Alkyl trimethyl ammonium bromide, ultrasonic disperse 30 minutes, resulting dispersion system；
The urea of 1.0g is added in S2 under stirring into above-mentioned dispersion, while the deionized water of 21ml is added, It is placed in 40 DEG C of water bath with thermostatic control and keeps the temperature；
0.8g tannic acids are added in the case where speed is 600 revs/min of stirring condition in S3, stir 6 minutes, and ammonium hydroxide is then added and adjusts PH value of solution is 9, obtains mixing suspension；
The polyvinylpyrrolidone of 2.6g is uniformly mixed by S4 with the ethyl orthosilicate of 22ml, obtains mixing dropping liquid, by this Mixing dropping liquid is slowly dropped in the mixing suspension, continues to be stirred to react 4 hours, separating, washing, drying obtains SiO2 Core@SiO2Shell micron particles；
S5 is by SiO obtained2Core@SiO2Shell micron particles are added in the hydrofluoric acid solution that volumetric concentration is 0.1%, Middle SiO2Core@SiO2The weight ratio of shell micron particles and the hydrofluoric acid solution is 2:10, etch 10 minutes is with to SiO2Shell carries out Pitting, separating, washing, drying obtain SiO2The porous SiO of core@2Shell micron particles；
S6 weighs the SiO2The porous SiO of core@2Shell micron particles 8.1g, is added in the absolute ethyl alcohol of 23ml, then adds Enter 0.12g azones and the Radix Et Rhizoma Nardostachyos extract of 10g, is kept for 1.2 hours under the conditions of 40 DEG C of waters bath with thermostatic control after stirring evenly；
The cetyl trimethylammonium bromide aqueous solution 5ml that mass concentration is 5%, ultrasonic disperse are added under S7 stirrings 10 minutes, the ethyl orthosilicate of 26ml is then slowly added dropwise, while it is 9.2 that ammonium hydroxide, which is added, to adjust pH value of solution, is added dropwise subsequent Continuous reaction 3 hours, separating, washing, drying obtains the MULTILAYER COMPOSITE silica dioxide granule that internal penetration is coated with Radix Et Rhizoma Nardostachyos extract, The mass ratio of Radix Et Rhizoma Nardostachyos extract and silica is 1 in this MULTILAYER COMPOSITE silica dioxide granule:28；Storage, it is spare；
S8 takes wetting agent and adhesive to be placed in container, and stirring makes it be uniformly mixed, and a certain amount of Radix Et Rhizoma Nardostachyos extract is being stirred It mixes and is slowly added under state in the mixture of wetting agent and adhesive, stirring obtains transparent colloid in 3 minutes；
S9 weighs the i.e. described MULTILAYER COMPOSITE silica dioxide granule of rubbing agent and Radix Notoginseng, borneol, basil oil are uniformly mixed, It is then added in the transparent colloid, stirring adds foaming agent, stir evenly to uniform paste is become；
It is filling after S10 vacuum outgas.
Stability of cream：
According to the national standard of GB8372-2008, embodiment 1-4 products are put into -8 DEG C of refrigerator, are taken after 8 hours Go out, be subsequently placed into 45 ± 1 DEG C of constant incubators and taken out after 8h, place 4h at room temperature, checks that lotion hardens whether there is or not dry and hard Situation, the results are shown in table below：
Color and luster, pH value, consistency of emulsifiable paste of the embodiment that makes discovery from observation 1-4 etc. are normal.
Clinical application evaluation
Select the patient 100 for having gingivitis, patient 100, the halitosis patient 100 of canker sore respectively by existing plan Example, the permanent tooth emulsifiable paste one week containing rhizoma nardostachyos obtained using embodiment 2 do not find adverse reaction and toxic side effect, and for tooth The healing effective percentage of oulitis patient is 98%, and the healing effective percentage for canker sore patient is 89%, for halitosis patient's It is 92% to cure efficient.
Clinical application is also carried out for the emulsifiable paste that other embodiments are obtained, as a result with embodiment 2 without bigger difference.
In short, product invention prepared by the present invention is aided with borneol, clore basil only using Radix Et Rhizoma Nardostachyos extract, Radix Notoginseng as main ingredient Oil, traditional Chinese medicinal components type is extremely simple and each component additive amount does not also dramatically increase compared with prior art, is subject to rhizoma nardostachyos extraction The special existence of object, good synergistic effect can be generated between each component, and there is product of the present invention strong root permanent tooth, heat-clearing to stop Blood, the effect for cleaning gum, deodorization and sterilization and fresh breath, especially have prophylaxis of teeth loosening, bleeding gums, gum swelling etc. Remarkable result.
It is above-described to be merely a preferred embodiment of the present invention, it should be understood that the explanation of above example is only used In facilitating the understanding of the method and its core concept of the invention, it is not intended to limit the scope of protection of the present invention, it is all the present invention's Any modification for being made within thought and principle, equivalent replacement etc., should all be included in the protection scope of the present invention.

Claims (4)

1. a kind of emulsifiable paste contains the permanent tooth emulsifiable paste of rhizoma nardostachyos, contain drug ingedient in the emulsifiable paste, it is characterised in that：The drug at Divide and be made of Radix Notoginseng, Radix Et Rhizoma Nardostachyos extract, borneol and basil oil, wherein the Radix Notoginseng accounts for the emulsifiable paste in terms of notoginseng total saponin The percentage of lotion weight be 0.05~0.1%, the Radix Et Rhizoma Nardostachyos extract account for the emulsifiable paste lotion weight percentage be 0.5~ 1%, the Radix Et Rhizoma Nardostachyos extract is petroleum ether extract of the rhizoma nardostachyos after alcohol reflux extracts, and the borneol accounts for the emulsifiable paste lotion The percentage of weight is 0.5~1%, and the percentage that the basil oil accounts for the emulsifiable paste lotion weight in terms of eugenol is 0.5~1%；Also contain rubbing agent in the lotion of the emulsifiable paste, the rubbing agent is MULTILAYER COMPOSITE silica dioxide granule, is accounted for described The percentage of emulsifiable paste lotion weight is 30~45%.
2. a kind of emulsifiable paste according to claim 1 contains the permanent tooth emulsifiable paste of rhizoma nardostachyos, it is characterised in that：The lotion of the emulsifiable paste In also contain wetting agent, adhesive and foaming agent.
3. a kind of emulsifiable paste according to claim 2 contains the permanent tooth emulsifiable paste of rhizoma nardostachyos, it is characterised in that：The wetting agent is sweet One or both of oil, sorbierite, propylene glycol, the percentage for accounting for the emulsifiable paste lotion weight are 20~30%；The bonding Agent is hydroxyethyl cellulose, and the percentage for accounting for the emulsifiable paste lotion weight is 0.6~2.5%；The foaming agent is dodecyl Sodium sulphate, the percentage for accounting for the emulsifiable paste lotion weight are 1.6~2.5%.
4. a kind of emulsifiable paste described in claim 1 contains the preparation method of the permanent tooth emulsifiable paste of rhizoma nardostachyos, which is characterized in that including as follows Step：
S1 weighs 3~8g Silica microparticles, adds it in the absolute ethyl alcohol of 120~150ml, while being added 1.2 ~1.8g cetyl trimethylammonium bromides, ultrasonic disperse 30~45 minutes, resulting dispersion system；
S2 under stirring into above-mentioned dispersion be added 0.9~1.6g urea, while be added 20~30ml go from Sub- water is placed in 40~50 DEG C of water bath with thermostatic control and keeps the temperature；
0.7~1.1g tannic acids are added in the case where speed is 600~800 revs/min of stirring condition in S3, stir 5~10 minutes, then add It is 9~9.5 to enter ammonium hydroxide to adjust pH value of solution, obtains mixing suspension；
The polyvinylpyrrolidone of 2.5~6g is uniformly mixed by S4 with the ethyl orthosilicate of 20~30ml, obtains mixing dropping liquid, will This mixing dropping liquid is slowly dropped in the mixing suspension, continues to be stirred to react 4~6 hours, separating, washing, drying Obtain SiO2Core@SiO2Shell micron particles；
S5 is by SiO obtained2Core@SiO2Shell micron particles are added in the hydrofluoric acid solution that volumetric concentration is 0.1~0.2%, Middle SiO2Core@SiO2The weight ratio of shell micron particles and the hydrofluoric acid solution is 2~3:10, etch 10-15 minutes is with to SiO2 Shell carries out pitting, and separating, washing, drying obtains SiO2The porous SiO of core@2Shell micron particles；
S6 takes the SiO2The porous SiO of core@2Shell 8~10g of micron particles, is added in the absolute ethyl alcohol of 20~35ml, then adds Enter 0.1~0.2g azones and the Radix Et Rhizoma Nardostachyos extract of 8~12g, after stirring evenly under the conditions of 40~50 DEG C of waters bath with thermostatic control keep 1~ 2 hours；
Cetyl trimethylammonium bromide 5~8ml of aqueous solution that mass concentration is 5%, ultrasonic disperse are added under S7 stirrings 10 minutes, the ethyl orthosilicate of 25~35ml is then slowly added dropwise, while it is 9~10 that ammonium hydroxide, which is added, to adjust pH value of solution, is dripped The reaction was continued 3~4 hours after finishing, and separating, washing, drying obtains the MULTILAYER COMPOSITE dioxy that internal penetration is coated with Radix Et Rhizoma Nardostachyos extract Silicon carbide particle, the mass ratio of Radix Et Rhizoma Nardostachyos extract and silica is 1 in this MULTILAYER COMPOSITE silica dioxide granule:20~30；
S8 takes wetting agent and adhesive to be placed in container, and stirring makes it be uniformly mixed, by a certain amount of Radix Et Rhizoma Nardostachyos extract in stirring shape It is added slowly under state in the mixture of wetting agent and adhesive, stirring obtains transparent colloid in 3~5 minutes；
S9 takes the MULTILAYER COMPOSITE silica dioxide granule and Radix Notoginseng, borneol and basil oil to be uniformly mixed, and is then added to institute It states in transparent colloid, stirring adds foaming agent, stir evenly to uniform paste is become；
It is filling after S10 vacuum outgas.
CN201810558096.1A 2018-06-01 2018-06-01 A kind of permanent tooth emulsifiable paste and preparation method thereof containing rhizoma nardostachyos Pending CN108714122A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110051541A (en) * 2019-06-06 2019-07-26 四川涑爽医疗用品有限公司 A kind of calcium hydroxide root canal disinfection paste and preparation method thereof

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11289900A (en) * 1998-04-16 1999-10-26 Fuji Shirishia Kagaku Kk Dentifrice for pet
US6241975B1 (en) * 1999-07-24 2001-06-05 Pacific Corporation Method for preparation of plant extract powder
JP2002212042A (en) * 2001-01-19 2002-07-31 Pacific Corp Method for producing plant extract powder and composition for oral cavity containing plant extract powder produced by the method
JP2009013157A (en) * 2007-07-06 2009-01-22 Kuan-Jiuh Lin Composition having graphitized cylindrical carbon compound and method for producing the same
KR20090076443A (en) * 2008-01-09 2009-07-13 주식회사 엘지생활건강 Fast soluble composition for oral and throat care
CN101637434A (en) * 2009-08-27 2010-02-03 天津大学 Preparation method of nuclear shell type CaCO3/SiO2 toothpaste abrasive
CN101991509A (en) * 2009-08-08 2011-03-30 赢创德固赛有限公司 Composite particles for use in oral hygiene
CN102670442A (en) * 2012-05-14 2012-09-19 云南云科药业有限公司 Panax notoginseng active ingredient-containing medicinal toothpaste and preparation method and application thereof
CN103274422A (en) * 2013-05-31 2013-09-04 肇庆市金三江化工有限公司 Core-shell sediment silica, preparation method and toothpaste containing silica
CN103977428A (en) * 2014-06-04 2014-08-13 福建卫生职业技术学院 Medicine release controlling and marking double-functional hollow nanometer mesoporous carrier material
CN105267113A (en) * 2014-06-30 2016-01-27 王岚 Odontolith prevention toothpaste and preparation method thereof
CN105813620A (en) * 2013-12-20 2016-07-27 高露洁-棕榄公司 Tooth whitening oral care product with core shell silica particles
CN107252410A (en) * 2017-05-25 2017-10-17 成都万雅迪生物科技有限公司 A kind of whitening toothpaste

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11289900A (en) * 1998-04-16 1999-10-26 Fuji Shirishia Kagaku Kk Dentifrice for pet
US6241975B1 (en) * 1999-07-24 2001-06-05 Pacific Corporation Method for preparation of plant extract powder
JP2002212042A (en) * 2001-01-19 2002-07-31 Pacific Corp Method for producing plant extract powder and composition for oral cavity containing plant extract powder produced by the method
JP2009013157A (en) * 2007-07-06 2009-01-22 Kuan-Jiuh Lin Composition having graphitized cylindrical carbon compound and method for producing the same
KR20090076443A (en) * 2008-01-09 2009-07-13 주식회사 엘지생활건강 Fast soluble composition for oral and throat care
CN101991509A (en) * 2009-08-08 2011-03-30 赢创德固赛有限公司 Composite particles for use in oral hygiene
CN101637434A (en) * 2009-08-27 2010-02-03 天津大学 Preparation method of nuclear shell type CaCO3/SiO2 toothpaste abrasive
CN102670442A (en) * 2012-05-14 2012-09-19 云南云科药业有限公司 Panax notoginseng active ingredient-containing medicinal toothpaste and preparation method and application thereof
CN103274422A (en) * 2013-05-31 2013-09-04 肇庆市金三江化工有限公司 Core-shell sediment silica, preparation method and toothpaste containing silica
CN105813620A (en) * 2013-12-20 2016-07-27 高露洁-棕榄公司 Tooth whitening oral care product with core shell silica particles
CN103977428A (en) * 2014-06-04 2014-08-13 福建卫生职业技术学院 Medicine release controlling and marking double-functional hollow nanometer mesoporous carrier material
CN105267113A (en) * 2014-06-30 2016-01-27 王岚 Odontolith prevention toothpaste and preparation method thereof
CN107252410A (en) * 2017-05-25 2017-10-17 成都万雅迪生物科技有限公司 A kind of whitening toothpaste

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
刘芹等: "新型SiO2/SiO2核壳型固定相的制备与评价", 《分析试验室》 *
宁向莉等: "多层核-壳结构复合微球材料制备研究进展", 《化学通报》 *
张卫明等: "《一带一路经济植物》", 30 November 2017, 东南大学出版社 *
王毅等: "Au和SiO2多壳结构的制备和表征", 《化学学报》 *
贺尊诗等: "《有机药物质谱鉴定》", 29 February 1996, 吉林科学技术出版社 *
陈杨等: "同质异构SSIO2/mSiO2核/壳复合磨粒的合成", 《材料研究学报》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110051541A (en) * 2019-06-06 2019-07-26 四川涑爽医疗用品有限公司 A kind of calcium hydroxide root canal disinfection paste and preparation method thereof
CN110051541B (en) * 2019-06-06 2022-03-22 四川涑爽医疗用品有限公司 Calcium hydroxide root canal disinfection paste and preparation method thereof

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Application publication date: 20181030