CN108697082A - Surface disinfection agent with remaining biocidal properties - Google Patents
Surface disinfection agent with remaining biocidal properties Download PDFInfo
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- CN108697082A CN108697082A CN201680079606.6A CN201680079606A CN108697082A CN 108697082 A CN108697082 A CN 108697082A CN 201680079606 A CN201680079606 A CN 201680079606A CN 108697082 A CN108697082 A CN 108697082A
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- oxazoline
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
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Abstract
The present invention provides the biomembrane sealing agent for giving remaining biocidal properties.Handle surface with biomembrane sealing agent has the ability for quickly killing bacterium and other germs to give film on treated surface at least 24 hours after deposition film.Biocide preparation biomembrane sealing agent includes polymer adhesive, the wherein amplification or polymer-modified of polymer adhesive Wei oxazolines homopolymer or Ji Yu oxazoline homopolymers;And Biocidal compounds.
Description
Cross-reference to related applications
This application claims the preferential of the U.S. Patent application 15/162,094 submitted on May 23rd, 2016 in U.S.Patent & Trademark Office
Power, U.S. Patent application 15/162,094 be require on November 23rd, 2015 to submit U.S. Patent application 14/949,046 preferentially
The part continuation application of power, U.S. Patent application 14/949,046 require the US provisional patent Shen submitted on November 26th, 2014
It please sequence number 62/084,917 and the U.S. Provisional Patent Application Serial No. 62/127,075 and 2015 submitted on March 2nd, 2015
The priority for the U.S. Provisional Patent Application Serial No. 62/166,403 that on May 26, in submits.The disclosure of which full text is by drawing
With being incorporated herein in.
Invention field
The present invention relates to biocide preparation fields, more particularly, are related to giving the biocide preparation of remaining biocidal properties.
Background of invention
Microorganism exists everywhere in Modern World.Although some are beneficial to human and environment, it is other can be to contaminated article
There is notable aftermath with people, animal and with the ecological member that they are contacted.There are some industry and environment, this is slightly raw wherein
Object is especially universal.
Health care
Hospital acquired infections (HAI;Or " nosocomial infection ") it is that hospital or health care environment promote the infection occurred.These diseases
Disease is generally fungi or bacterium infection, and can topically or systemically torment patient.Nosocomial infection can cause serious pneumonia and urine
The infection in road, blood flow and other body parts.
For patient and caregiver, nosocomial infection has serious medical problem.In the U.S., statistics indicate that annual occur about
1,700,000 hospital's infections relating case, wherein causing close to 100,000 death.European data and investigation show only lattice
Lan Shi negative microbial infections just cause annual 8,000-10,000 death.
There are several Acute aggravated factors to facilitate high HAI rates.Hospital, urgent care centers, sanatorium and similar facilities collect treatment
In in the patient with serious disease and damage.Therefore, having for the abnormal high concentration of these facilities receiving weakens immune system
Patients.
One group of three pathogen is generally found that in health care environment, and accounts for the about one third of nosocomial infection jointly:It is solidifying
Gu enzyme negative Staphylococcus (15%), candida albicans (11%) and Escherichia coli (10%).
Worse, be present in these environment is more obstinate disease-producing pathogens.There are six kinds of so-called " ESKAPE cause of diseases
Body " has antibiotic resistance, and nearly half has and involves in all nosocomial infections, they are enterococcus faecalis
(Enterococcus faecium),Staphylococcus aureus (Staphylococcus aureus),Friedlander's bacillus
(Klebsiella pneumoniae),Acinetobacter baumannii (Acinetobacter baumannii),Pseudomonas aeruginosa
(Pseudomonas aeruginosa) and enterobacteria (Enterobacterspecies).To one or more biocides
Drug resistance makes these infect special hazard.
In particular, the wide nutrition versatility of pseudomonad allows it to survive in extreme environment, it is included in thoroughly unclear
It survives on clean and sterilizing surface.Gram-negative nosocomial infection is become in the generally existing of this pathogen of hospital environment
Inducement.Be particularly vulnerable to infringement is that immunocompromised patient (is suffered from for example, suffering from those of cystic fibrosis, cancer or burn
Person).
The most common mode of HAI is by direct or indirect contagion.Immediate contagion includes contacting to get dirty to catch
The patient of person or staff.Since caregiver's movement passes through health care facility, they and its many patient contact.
When they look after lodging person, these work people unwittingly activity in a manner of similar to the garden peaks Zhong Mi, in room and ward
" pollination ".
In the contaminated object of patient contact or surface, mediate contact occurs and infects.Health care environment provides can be by
The a collection of article of dynamic guiding pathogen.
Amount, quality and the cost that the health care that hospital and other mechanisms provide is returned in nosocomial infection bring heavy blow.
In addition to occurring rough 100 every year in the U.S., outside 000 HAI associated death, also force the patient of 2,000,000 or more estimation endure with
The relevant actual bodily harm of these serious and evitable diseases and mental suffering.
Mechanism is reacted by policies, and tightened up cleaning and sterilization are subject to staff and patient environmental
It is required that.These programs, which generally comprise, often washes one's hands and frequent surface disinfection.Although executing program controls nosocomial infection, with not
Acceptable high rate is infected.
Household care and family
Home environment also faces microorganism.It is with consumer's fungicide and the relevant major defect of disinfectant, although they can
It is effectively initial to kill microorganism, but the microorganism that is easily and quickly carried by contact, air of surface and do not kill before treatment
Dead residual microbial recontamination.Although if be simply left on surface, some fungicide will continue to give some controls,
This will produce grease or viscous residue, be easy to be failed by carelessly contacting with surface.Therefore, it is necessary to a kind of household care and
Household cleaning agent, the detergent quickly kill microorganism at the time of contact, are then used as remaining fungicide, but it is this departing from
The viscosity needed or adhesion effect.These detergents can be used for general purpose household cleaning, bathroom cleaner and spraying protective agent.
Difference between hospital and health care detergent and homebrew is VOC (the organic contents of volatility allowed
Object).Regulation to most of non-aerosol household consumption fungicide is 1% VOC maximum values.
Catering service
Diet service trade also faces in workplace pathogen contamination and transmission to the accident of consumer.Even if food
Manufacturer is using strength sanitary equipment and abides by stringent Government Health regulation, is still reported in once in a while in consumer and causes serious disease
The microorganism vital emergent event of disease.There is the fungicide of residual activity that this problem should be effectively relieved.
Biomembrane
Biomembrane is commonly defined as being adhered to the microbial layer of the secretion biological source protective coating of body structure surface, and body structure surface can be with
For organic or inorganic.Due to increase biomembrane correlation organism combating microorganisms agent patience and biomembrane carry it is organic
Body causes the possibility of infection, biomembrane to cause big problem to public health.Therefore, it is necessary to the relevant sterilization side of biomembrane
Case.Current fungicide has no ability to kill the biomembrane in biomembrane or closing or latch surface to prevent cross contamination event
With prevent hyperplasia.It is limited to surface biological film solution to the problem.For example, evidence suggests surface biological film is due to above-mentioned
Reason causes health care environment problem.In addition, in grocery trade, biomembrane is also the recognized problem that may be polluted.Other rows
Industry also faces similar problems.Therefore, it is necessary to the solutions that can be used for eradicating biomembrane for potential source biomolecule film problem area.
Generally, it is still necessary to the preparation of remaining biocidal activity can be given to treated surface.If said preparation with
Surface disinfection agent combination can single cleaning reach and sterilize and give remaining biocidal effect, then it is more advantageous.
More advantageously remaining biocidal properties are persistently related to treated surface so that through a long time can hold after the application
It is continuous that microorganism reduction is provided.
In the industry of wide scope and application effectively more advantageously if there is preparation.
Summary of the invention
The present invention relates to the biocide preparations for giving remaining biocidal properties.Biocide preparation includes polymer adhesive, wherein polymerizeing
The amplification or polymer-modified of object adhesive Wei oxazolines homopolymer or Ji Yu oxazoline homopolymers;And Biocidal compounds.It kills
Bacteria preparation includes to further include carrier.
, oxazolines homopolymer has structure in one aspect of the invention:
Wherein R1For hydrogen, alkyl, alkenyl, alkoxy, alkyl amino, alkynyl, allyl, amino, anilino-, aryl, benzyl, carboxylic
Base, carboxyalkyl, carboxyalkenyl, cyano, glycosyl, halogenated, hydroxyl, Jia Huang Suan oxazolines, Jia Ben Huang Suan oxazolines, trifluoro
Jia Huang Suan oxazolines, Jia Gui Wan oxazolins, phenol, poly-alkoxyl, quaternary ammonium, mercaptan or thioether group;R2For hydrogen, alkyl, alkene
Base, alkoxy, alkyl amino, alkynyl, allyl, amino, anilino-, aryl, benzyl, carboxyl, carboxyalkyl, carboxyalkenyl,
Cyano, glycosyl, halogenated, hydroxyl, Jia Huang Suan oxazolines, Jia Ben Huang Suan oxazolines, San fluorine Jia Huang Suan oxazolines, monosilane
Oxazolin, phenol, poly-alkoxyl, quaternary ammonium, mercaptan or thioether group or macrocyclic structure;R3For hydrogen, alkyl, alkenyl, alkoxy, virtue
Base, benzyl, hydroxy alkyl or perfluoroalkyl;And n is in the range of 1 to 1,000,000.
The other feature of biocide preparation is provided in another aspect of the present invention.
The product with biocide preparation of the present invention is provided in another aspect of the present invention, and manufactures, use and application is killed
The method of bacteria preparation.
By detailed description presented below, other ranges of applicability of the present invention will become obvious.Although it will be appreciated that pointing out
The preferred embodiments of the invention, but be described in detail and specific embodiment simply to illustrate that, rather than to limit the model of the present invention
It encloses.
DESCRIPTION OF THE PREFERRED
It is exemplary in nature that following present invention embodiment, which is described in detail only, is not limit the invention in any way, it is applied or purposes.This
Invention has wide potential use and application, it is contemplated that can be applicable in wide scope industry.It is provided herein described below to be only used as
What example provided the present invention allows disclosure, and does not limit the scope of the invention or content.
Terms used herein " microorganism " or " microorganism " should be interpreted that finger is studied by microbiologist or through processing
The microcosmic organism found in article use environment.These organisms include but not limited to bacterium and fungi and other unicellular
Organism, such as mould, mould and algae.Also include virom crosome and other infection media in term microorganism.
It should also be clear that " antimicrobial " includes killing both microorganism and suppression microorganism property.That is, the term includes that kill is micro-
Biology, cause reduce microbe number and microorganism growth inhibition, wherein number can almost remain unchanged (however allow
It is slightly increased/reduces).
In order to be easy to discuss, this description term is antimicrobial to indicate broad spectrum of activity (for example, to bacterium and fungi).It is carrying
When to the effect of specific microorganism or classification grade, using more dedicated term (for example, in particular, antimycotic indicate pair
The effect of fungi growth).
Use above example, it should be understood that not excluding identical antimicrobial compositions in any way to the effect of fungi can
Other kinds of quasi-microorganisms are shown with the possibility of effect.
For example, the discussion of the strong bacterium effect shown by disclosed embodiment should not be construed as the embodiment and will not show
Show antifungal activity.This method is expressed to should not be construed as limiting the scope of the invention in any way.
Biocide preparation
The present invention relates to a kind of biocide preparations.In one aspect of the invention, biocide preparation is liquid form.Biocide preparation combines
Object includes Biocidal compounds and polymer adhesive.Composition can especially further include solvent (such as water or low molecular weight
Alcohol), surfactant, colorant, aromatic.
The liquid composition of preparation has surface disinfection and remaining biocidal properties.Preparation can pass through sprinkling, rolling, mist
Change, wiping or other methods are applied to surface.Preparation kills existing microbial infection on the surface as surface disinfection agent.
Once dry, liquid preparation just leaves remaining protective film on the surface.Residual film has biocidal properties, can
Enough through a long times after the application protect microbial contamination holding surface.
In a preferred embodiment, surface disinfection preparation gives film on treated surface at least 24 after deposition film
The ability of bacterium and other germs is quickly killed in hour.In one aspect of the invention, it quickly kills and refers generally to about 30 seconds extremely
About 5 minutes time.Film will retain on the surface, and resistance to multiple-contact and surface abrasion.
In another embodiment of the present invention, biocide preparation is liquid composition, which includes polymerization
Object adhesive, Biocidal compounds, carrier (such as solvent) and other optional components (such as aromatic).
Biomembrane sealing agent
In one embodiment of the invention, biocide preparation is biomembrane sealing agent.Once being applied to surface, biomembrane sealing
Agent just forms polymer film.The wet application of polymer film, and dry is film layer, to be latched and prevent subsequent biofilm microorganisms from increasing
It is raw.Biomembrane sealing agent, although it is preferred that in liquid form, other forms can be also taken, such as gel or other forms.Once raw
Object film sealant is in place, and the microorganism of biomembrane has just limited the entrance of oxygen and exogenous nutrition object.Biomembrane sealing agent
Potential sealing bacterium, and extend antimicrobial and discharge into film, to kill the microorganism in biomembrane.
In one embodiment of the invention, biomembrane sealing agent includes polymer adhesive and Biocidal compounds.
Biocidal compounds may include but be not limited to any Biocidal compounds as described herein.
In one embodiment of the invention, biomembrane sealing agent Bao Han oxazoline homopolymers are as polymer-bonded
Agent.Oxazoline homopolymer can have any structure described herein.
In one embodiment of the invention, biomembrane sealing agent include polymer adhesive, Biocidal compounds and
Enzyme.Enzyme helps degradation biological film, and promotes biocide is antimicrobial to penetrate, and finally removes biomembrane.Example enzyme includes but not
It is limited to protease, DNase, RNase and the degradable and relevant extracellular matrix of biomembrane sugared specific enzymes.
In one embodiment of the invention, biomembrane sealing agent is comprising polymer adhesive and as slowly releasing
Put the antibody of the biomaterial into film into.Antibody function body is incorporated into biofilm microorganisms, to prevent cross contamination.
In one embodiment of the invention, biomembrane sealing agent is comprising polymer adhesive and as slowly releasing
Put bacteriophage or the phage mixture of the biomaterial into film into.Bacteriophage kills biomembrane knot as targeted antimicrobial agent
The organism of conjunction.
In one embodiment of the invention, biomembrane sealing agent includes polymer adhesive, and as slow
Discharge into the bacteriophage of the biomaterial of film, the mixture of antimicrobial, enzyme and antibody.
Polymer adhesive
In one aspect of the invention, polymer adhesive Wei oxazolines homopolymer.As another feature of the invention , oxazoles
Quinoline homopolymer has following structure:
Wherein
R1And R2For the end group that polymerization technique determines used in conjunction oxazoline homopolymer.R1And R2Independent choice and include but not
It is limited to hydrogen, alkyl, alkenyl, alkoxy, alkyl amino, alkynyl, allyl, amino, anilino-, aryl, benzyl, carboxyl, carboxyl
Alkyl, carboxyalkenyl, cyano, glycosyl, halogenated, hydroxyl, Jia Huang Suan oxazolines, Jia Ben Huang Suan oxazolines, trifluoromethanesulfonic acid
Oxazoline, Jia Gui Wan oxazolins, phenol, poly-alkoxyl, quaternary ammonium, mercaptan or thioether group.Alternatively, R2It may include in the synthesis phase
Between due to intramolecular attack formed macrocyclic structure.
For example, R1For methyl, R2For Jia Ben Huang Suan oxazolines, if the cation of oxazolines, which causes in polymerization, is used first
Methyl benzene sulfonate is as initiator.
R3For by preparing the end group that used oxazoline type determines in Inventive polymers adhesive.R3Including but not limited to
Hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxy alkyl or perfluoroalkyl.For example, R3For ethyl, if ethyl oxazoline
For the monomer for preparing used in Inventive polymers adhesive.
N is the degree of polymerization of homopolymer Zhong oxazolines.N is in the range of 1 to 1,000,000.It is preferred that n is 500 to 250,000
In the range of, most preferably n is in the range of 2500 to 100,000.
For Lei Si Yu oxazoline homopolymers, Ji Yu oxazoline homopolymers have the amplification or polymer-modified be also suitable that some change
In the present invention.Dui oxazolines carry out chemistry or the technology and selection of molecule structure change or modification should be those skilled in the art
It is familiar with.The amplification of Ji Yu oxazoline homopolymers or polymer-modified type can be used to lower structure representation:
Wherein
R1And R3With Yu identical definition given in oxazoline homopolymer Shang Yi.
B is the other monomeric repeating unit for being connected to Gong polymers Zhong oxazolines.Weight between B and Gong polymers Zhong oxazolines
The arrangement type of multiple unit may include but be not limited to block, alternating, period or combinations thereof.It is total with oxazoline of the present invention to can be used for
There is no limit for the type of B that is poly- or making oxazoline modification of the present invention.
The degree of polymerization of n Wei oxazoline repetitive units, the n in copolymer in the range of 1 to 1,000,000, meanwhile, about
The degree of polymerization m of B repetitive units is in the range of 0 to 500,000 in copolymer.It is preferred that n is in the range of 500 to 250,000, m
In the range of 20 to 10,000;Most preferably n is in the range of 2500 to 100,000, and m is in the range of 50 to 5,000.In addition to
So that B is connected to outside ethyl oxazoline by copolymerization, if B itself has been quaternary ammonium compound, B also can Lian Jie Dao oxazoline, with B
As in the cationic polymerization of cationic initiator be used as end group.
It is not meant to as completely including property, B may be, for example, the aziridine with following molecular structure:
Wherein
R1And R2End group has and identical definition described in Guan Yu oxazoline homopolymers.
R3Including but not limited to hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxy alkyl or perfluoroalkyl.
R4Including but not limited to hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxy alkyl or perfluoroalkyl.
M is in the range of 0 to 500,000, preferably in the range of 20 to 10,000, most preferably 50 to 5,000 model
In enclosing.
N is in the range of 1 to 1,000,000, preferably 500 to 250,000, most preferably 2500 to 100,000 range
It is interior.
The synthesis of Li such as , oxazolines and ethyleneimine copolymer can be divided into two steps.In first step, cation can be used
Ring-opening polymerisation technology prepares polyoxazoline homopolymer.In second step, can make to prepare the hydrolysis of polyoxazolines in first step, with
Bu Fen polyoxazoline repetitive units are made to be converted to polyethyleneimine.Alternatively, suitable corresponding monomer, oxazolines and aziridine can be used
Bei oxazolines-ethyleneimine copolymer processed.As a result can be the cationic polymer with the above structure.
Polymerization degree n about Gong polymers Zhong oxazoline repetitive units in the range of 1 to 1,000,000, meanwhile, about altogether
The degree of polymerization m of ethyleneimine repeat units is in the range of 0 to 500,000 in polymers.It is preferred that ranges of the n 500 to 250,000
Interior, m is in the range of 20 to 10,000;Most preferably n is in the range of 2500 to 100,000, and m is in the range of 50 to 5,000.
Alternatively, the nitrogen in ethyleneimine repeat units can be further quaternized, to generate following cationic copolymer:
It can make the polymeric quartenary ammonium of this example with any quaternized technology familiar to the person skilled in the art.R1,R2,R3And R4
With Yu identical meaning shown in oxazoline-ethyleneimine copolymer Shang Yi.R5Including but not limited to hydrogen, methyl, ethyl, third
Base or other types of alkyl.Corresponding anion X-For halogen, sulfonate radical, sulfate radical, phosphonate radical, phosphate radical, carbonate/carbon
Sour hydrogen radical, hydroxyl or carboxylate radical.
It is identical described in range Ye Yu oxazoline-ethyleneimine copolymer about n and m.
Another example of B for use in the present invention is diallyl dimethyl ammoniumchloride.With polydiene dimethylamine
The polyethyloxazoline that ammonium chloride is modified has following structure:
Wherein
R1And R4With with identical meaning described in the former example about Ji Anization oxazoline-ethyleneimine copolymer.
R2And R3Independent includes but not limited to short-chain alkyl, such as C1To C6.Corresponding anion X-For halogen, sulfonate radical, sulphur
Acid group, phosphonate radical, phosphate radical, carbonate/bicarbonate, hydroxyl or carboxylate radical.
N and m is defined and is counted identically with former example.
B can be other alkene, including but not limited to diallyldimethylammonium chloride, styrene, methoxy styrene
And methoxy-ethylene.Ethyl oxazoline can be also copolymerized with heterocyclic monomer, such as ethylene oxide, Thietane, 1,3- dioxanes
Heptane, oxetanes -2- ketone and tetrahydrofuran, to enhance the performance of Inventive polymers.Adhesive therefor in the present invention
Using the oxazolines side group Shang polymer backbone, such as acrylic compounds or styrene-based polymer, or contain acrylic compounds or benzene
The copolymer of ethylene.
The example of commercially available polyethyloxazoline includes but not limited to be purchased from Polymer Chemistry Innovations,
The Aquazol 500 of Inc.
The amount that can be used for the polymer adhesive of liquid preparation may depend on the active required length of composition residues and group
It closes the property of all other component in object and changes to a certain extent.The amount of polymer adhesive is preferably based in liquid preparation
Liquid preparation weight is in the range of 0.1% to 20%.In the liquid preparation for healthcare application, it polymerize in liquid preparation
The amount of object adhesive is more preferably in the range of 0.5% to 10%, most preferably in the range of 0.8% to 5%.For general and bath
In the liquid preparation of room detergent, the amount of polymer adhesive is optimal more preferably in the range of 0.1% to 10% in liquid preparation
It is selected in the range of 0.1% to 5%.
Polymer adhesive is preferably water solubility, and can easily be removed from surface, if it is noted that there is any accumulation.So
And it is on a small quantity in the presence of that can provide durable bond between Biocidal compounds and treated surface, to promote residual effectiveness.
Biocidal compounds
Biocidal compounds can be the quaternary ammonium compound (QAC) with following molecular structure:
Wherein
R1,R2,R3And R4It is independently selected from and including but not limited to alkyl, alkoxy or aryl, with or without hetero atom, or
Person is saturated or unsaturation.Some or all of functional groups can be identical.
Corresponding anion X-Including but not limited to halogen, sulfonate radical, sulfate radical, phosphonate radical, phosphate radical, carbonate/carbon
Sour hydrogen radical, hydroxyl or carboxylate radical.
QAC includes but not limited to n alkyl dimethyl benzyl ammonium chloride, di-n-octyl alkyl dimethyl ammonium chloride, dodecyl two
Ammonio methacrylate, saccharin n alkyl dimethyl benzyl ammonium and 3- (trimethoxysilyl) propyl-dimethyl octadecyl chlorination
Ammonium.
The combination of monomer QAC is preferred for the present invention.The specific example of QAC combinations is n alkyl dimethyl benzyl ammonium chloride
(40%), n-octyl decyl dimethyl ammonium chloride (30%), two positive decyl alkyl dimethyl ammonium chlorides (15%) and di-n-octyl dimethyl chloride
Change ammonium (15%).Percentage is the weight percent of the independent QAC based on mixing QAC composition total weights.
The type of polymer for the QAC having following structure can also be used for the present invention.
Or
Wherein
R1,R2,R5And R6Independent includes but not limited to hydrogen, methyl, ethyl, propyl or other longer carbon alkyl.
R3And R4Independent choice and including but not limited to methylene, ethylidene, propylidene or other longer alkylidene connections
Base.
N is the degree of polymerization, and n is the integer in 2 to 10,000 ranges.
Example with the above structural cation polymer is including but not limited to obtained from dimethyl amine and epichlorohydrin poly-
Amine is such as purchased from the Superfloc C-572 of Kemira Chemicals.
It is diallyl dimethyl ammoniumchloride or poly- DADMAC to be suitable for the invention other polymerization QAC.
The QAC for being suitable for the invention other type is to have those of biguanide moiety compound in the molecule.Such sun
The example of ion antimicrobial includes but not limited to PHMB and Chlorhexidine.
The example of commercially available quaternary ammonium compound includes but not limited to the Bardac 205M and 208M purchased from Lonza and is purchased from
The BTC885 of Stepan Company.
Biocidal compounds can be weak acid, and it is especially effective in bathroom detergent that weak acid has been displayed.It is produced in these types
In product, citric acid, dithiocarbamic acid (also being known as sulfamic acid), glycolic, lactic acid, lauric acid and capric acid can be used as and effectively kill livestock
Agent and detergent are used for soap scum and hard water deposit.
Available other compounds are silane quaternary salt, such as 3- (trihydroxy silicyl) propyl-dimethyl octadecyl chlorination
Ammonium.These can have the additional benefit reacted with surface to be processed for enhancing residual property.
Other Biocidal compounds suitable for fluid present invention preparation cross over the antimicrobial of wide scope, biocidal
Agent, disinfectant and fungicide.It is preferred that water-soluble or dispersed Biocidal compounds, but utilize the biocidal for dissolving in alcohol for selecting
Agent.
The non-exhaustive list of Biocidal compounds suitable for invention formulation includes triclosan, zinc pyrithione, metal
Salt and oxide, phenol, plant material, halogen, peroxide, heterocycle antimicrobial, aldehyde and alcohol.
The concentration of Biocidal compounds can be in the range of 0.05% to 20% based on liquid composition weight in preparation.For
For the liquid preparation of healthcare application, preferably in the range of 0.1% to 20%, more preferably in the range of 0.5% to 3%.
For for general and bathroom detergent liquid preparation, preferably in the range of 0.05% to 10%.For for protective agent
Preparation, preferably in the range of 0.05% to 2%.
Carrier
Carrier or medium for fluid present invention preparation can be volatility and be easy to evaporate in environmental condition any molten
Agent.The example of liquid-carrier includes but not limited to water and low-molecular-weight alcohol, such as C1 to C8 alkanols.Specific example includes but not limited to
Ethyl alcohol, isopropanol, butanol, amylalcohol and combinations thereof.
Another kind of solvent for the present invention includes alkane glycol ethers.Example includes but not limited to ethylene glycol ether, second two
Alcohol monobutyl ether, ethylene glycol monohexylether, ethylene glycol monohexylether, diglycol monomethyl ether, diglycol list ether, a contracting
Diethylene glycol monobutyl ether, diglycol monohexyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, two contractings
Triethylene glycol butyl ether, propylene glycol monomethyl ether, propylene glycol methyl ether acetate, propylene glycol n-butyl ether, dipropylene glycol n-butyl ether, one
Contracting dipropylene glycol methyl ether, dipropylene glycol methyl ether acetic acid esters, Propylene glycol n-propyl ether, dipropylene glycol positive propyl ether and two contractings three
Propylene glycol monomethyl ether.
It is suitable for the invention another kind of solvent and is based on terpenes and its derivative, such as terpenol, terpenoid, terpenes ether or terpene
Olefine aldehydr.The example of solvent includes but not limited to pine tar, lemon oil, limonene, firpene, cymene, laurene, fenchone, borneol, promise
Foretell alcohol, cineole, ionone etc..
It is water for the preferred vector in the liquid preparation of residential care clean applications.
If the applying method of fluid present invention preparation is pressurised aerosol, propellant may be needed in the composition.
A variety of propellants or mixture can be used for the present invention, and should be those skilled in the art and be familiar with.C1 is to C10 hydrocarbon or halogenated hydrocarbons
For the typical propellant agent in aerosol combination known in the industry.The example of these propellants includes but not limited to pentane, fourth
Alkane, propane and methane.Other type propellants for use in the present invention further include compressed air, nitrogen or carbon dioxide.Alternatively, can
Make product aerosolization with capsule valve module, without propellant is applied directly to composition.
The mixture of single solvent or more solvent can be used for the present invention.Type of solvent for the present invention may depend on residual
The desired use of remaining bactericidal composition.For example, if the composition of the present invention is intended for residential care purposes, cleaning is got dirty
Dye surface may be primarily upon with eliminating all types dirt or dirt.Help and promote to go liquid-carrier or the Jie of dirt
Matter can be the preparation of the present invention.For example, in order to there is better clean-up performance in the residential care type of invention formulation, this
The remaining biocide preparation or composition of invention may need to include alkyl or more alkyl diol ethers.On the other hand, if remnants are killed
It is the health care facilities of hospital acquired infections that the main target of bacteria composition, which is for main problem, then this hair of rapid draing
Bright liquid composition may be than more catering to the need from surface removing dirt or dirt.Being considered as low-molecular-weight alcohol contributes to this hair
The rapid draing after the application of bright liquid preparation.Low-molecular-weight alcohol in liquid preparation also lives the disinfection for enhancing liquid composition
Property.
For the health care use of remaining fungicide, the preferably mixture of water and low-molecular-weight alcohol.It is deposited in liquid preparation
Alcohol azeotropic mixture of the amount preferably between liquid preparation can be formed in alcohol and water level.If it does, liquid
The minimum of alcohol is 10% in composition.For the health care use of remaining fungicide, determining alcohol 30%, for of the present invention group
The health care use most preferably determining alcohol for closing object is at least 50%, is based on liquid preparation weight.
Surfactant
Using surfactant or wetting agent.Surfactant helps liquid preparation to sprawl and uniformly coat table to be processed
Face.Surfactant additionally assists in the azeotropic mixture between being formed in alcohol and water, therefore is once applied to surface, just promotes liquid
Body preparation is rapidly and uniformly dried.Surfactant is also in the remaining bactericidal liquid system of the present invention for residential care purposes
It plays an important role in agent, if the soil cleaning performance key feature to be had that is deisgn product.
Surfactant suitable for fluid present invention preparation includes but not limited to for nonionic, anion or amphotericity
Those surfactants.The example of commercially available wetting agent include but not limited to purchased from Dow Chemical Ecosurf SA-4 or
Tergitol TMN-3 and Q2-5211 purchased from Dow Corning.
When QAC is used as Biocidal compounds in the formulation, oxide surfactant is particularly preferred.
In nonionic surfactant type, can be used has not same amount ethylene oxide or the ethoxylated alcohol of HLB value.
The example of ethoxylated alcohol includes but not limited to Triton X-100 (Dow Chemical, Midland MI), is purchased from Dow
The Ecosurf EH nonionic surfactants series of Chemical, the Tergitol non-ionic surfaces purchased from Dow Chemical
Activating agent series, the Surfonic surfactants purchased from Huntsman Corp., the surfaces Neodol purchased from Shell are lived
Property agent series, the Ethox surfactants purchased from Ethox Chemicals and be purchased from Air Products and
The Tomadol surfactants of Chemicals, Inc..
Another kind of nonionic surfactant includes alkyl polyglucoside.Example includes the Glucopon series purchased from BASF
With the Ecoteric series purchased from Huntsman.
Be preferred for the surfactant of liquid preparation is silane based surfactants for seed selection class.Example includes but not
It is limited to silicone polyether organo-functional or reactive silane wetting agent and fluorochemical wetting agent.
The content of surfactant is in the range of 0% to 10% in liquid preparation, preferably in the range of 0.01% to 5%.
According to intended applications, the liquid preparation of the present invention for residential care purposes may need to be suitble to pH conditions.Example
Such as, if product liquid is used for kitchen area, in order to effectively remove the greasy dirt generally found in this region, it may be necessary to high pH
Product.If product is used for bathroom area, soap scum and hard water deposit may be main problem.In this case, low pH
Product may be more suitable for this purposes.Pair can be added the type of the pH adjusting agent of fluid present invention composition there is no limit.PH can be used
The example of conditioning agent include but not limited to triethanolamine, diethanol amine, monoethanolamine, sodium hydroxide, sodium carbonate, potassium hydroxide,
Potassium carbonate, calcium carbonate, citric acid, acetic acid, hydrochloric acid, sulfamic acid, sulfuric acid etc..
Can include other functional components other than component mentioned above in the liquid composition of the present invention.In addition subpackage is organized
Include but be not limited to chelating agent, compatilizer, coupling agent, corrosion inhibitor, rheology modifier, aromatic, colorant, preservative, UV
Stabilizer, fluorescent whitening agent and active constituent indicator.
In one embodiment of the invention, liquid solution includes polymer adhesive, quaternary ammonium compound, polysiloxanes
Based surfactants and ethyl alcohol.Any conventional method preparation well known by persons skilled in the art or mixing liquid preparation can be passed through.
Preparation about the present invention is not preferably added to method, and condition is that preparation is final uniform, compatible and stable.For example, if poly-
Conjunction object adhesive is solid, then preferably so that polymer is dissolved or dispersed in carrier first, such as water or alcohol, is polymerize with preparing deposit
Object binder liq dispersion.The present invention can be easily added during combination process by laying in polymer adhesive liquid dispersion
Preparation.
Liquid preparation is applied
Liquid preparation can be applied in a variety of ways.If sprinkling, liquid preparation can be favorably in the conventional bottle with sprayer
It provides.Sprayer can be triggering sprayer.Option as triggering sprayer, it is also possible to which liquid preparation is transported to by aerosol
On surface.Other method of administration includes but not limited to atomization, roll-in, brushes, smears and use wiping by various application devices.
In the scope of the present invention, can also manufacture comprising the present invention biocide preparation or use its pretreated wipe product, for example, for show
Goods is sold or is used.
In order to be sterilized to contaminated surface, sprinkling liquid preparation is until region is completely covered.Then, dry cloth or paper handkerchief can be used
Dry wipe wet preparation.
According to aspects of the present invention, the present invention also relates to the articles handled with biocide preparation.
Embodiment
Following embodiment illustrates according to the liquid preparation prepared in terms of the present invention.Test result about these preparations is shown
On being administered to surface and the remnants of drying period prestige are sterilized or bactericidal property.Also the clean-up performance of those preparations is tested, those
Preparation not only provides remaining bactericidal benefits, but also provides cleaning feature.
With the residual effectiveness of EPA 01-1A regulation test preparations.In brief, bacterium is added to slide, and makes it in table
It is dry on face.Then preparation is sprayed onto on surface, and drying forms hyaline membrane.Once film is formed, with Gardner wear tests
Instrument makes slide be exposed to alternately wet dry cycle, as described in regulation.Between each cycle, with bacterium renewed vaccination slide.Suitable
(for 48 abrasions of health care preparation and 11 renewed vaccinations, for residential care after the abrasion of conjunction and renewed vaccination number
24 abrasions of preparation and 5 renewed vaccinations), so that slide is exposed to time range (that is, 5 minute) of the bacterium by instruction, then
It is recycled in being suitble to and in solution.
Other than residual effectiveness, the initial potency of the present composition is tested also according to ASTM E 1153.
The hard-surface cleaning performance of home care compositions of the present invention is evaluated with the ASTM D4488 of modification.Use is with the following group
At dirt for evaluating.
Table 1
| Component | The weight percent (%) of each component |
| Pure plant oil | 75 |
| TM-122 AATCC woollen blanket dirts | 25 |
* TM-122 AATCC woollen blankets dirt is obtained from Textile Innovators.
During preparing the dirty ceramic tile used in cleaner assay, about 2 grams of liquid insults are placed on aluminium foil.With roller in foil
It is upper to roll and sprawl dirt, and so that roller is inhaled as much as possible and pick up dirt.By rolling dirty roller on porcelain surface, make the dirt on roller
Object is uniformly transferred on the glazed surface of ceramic tile.Then dirty ceramic tile is being toasted in 180 DEG C of baking oven 45 minutes.For
Before cleaner assay, toasted brick is adjusted 24 hours in room temperature.
Gardner Wear Testers are used in cleaner assay.The scouring pad of about 1cm width is attached to abrasion boat to be used for
Abrasion.About 4 grams of test preparations are put into weighing boat.The scouring pad of attachment is immersed and weighs boat, test preparation is picked up to inhale.
After pad is moistened with cleaning formulation, cleaning process is immediately begun to.Use in test 7 abrasions (rearwardly and a forwardly)
Cycle.
Remaining fungicide embodiment for health care
In order to provide the quick-drying property of liquid preparation, the following preparation in embodiment uses alcohol as main carriers.
Table 2
Residual effectiveness experiment is carried out with EP01-1A regulations, the results listed in the following table.
Table 3
| Preparation | (average log bacteriums are reduced EP01-1A) |
| HE1 | 3.53 |
| HE2 | 5.50 |
| HE3 | 4.50 |
These preparations, which are shown, tests splendid residual effectiveness result based on EP01-1A.
The initial biocidal properties of HE2 are evaluated according further to 1153 testing regulations of ASTM E.Test result is shown in following table
In.
Table 4
These data clearly illustrate have in instruction time model with the sample surfaces that exemplary fluids preparation disclosed herein is handled
Enclose apparent biocidal activity.
Remaining Bactericidal cleaner embodiment for residential care
Water is used to prepare these compositions as carrier.They are intended for residential care purposes, are provided against in this VOC most of
The use of high-content organic solvent such as alcohol.
Table 5
The residual effectiveness of these preparations is evaluated with EP01-1A regulations, the results listed in the following table.
Table 6
| Preparation | (average log bacteriums are reduced EP01-1A) |
| H1 | 3.53 |
| H2 | 5.50 |
| H3 | 5.50 |
| H4 | 4.90 |
| H5 | 3.80 |
Clostridium perfringen is the bacterium tested for H1, and staphylococcus aureus is the bacterium of the experiment for remaining preparation.
Test result shows that H1 to H5 provides residual effectiveness to treated surface.Also with the ASTM D4488 examinations of modification
Proved recipe method evaluates clean-up performance.
Test result will also recognize that ground visual display, preparation of the invention not only provide the residual effectiveness to bacterium, Er Qieti
For excellent clean-up performance on dirty surfaces.
About other preparation shown in residential care and household cleaning application test following table.In order to dissolve aromatic,
Prepare the pre-composition comprising aromatic, quaternary ammonium compound, surfactant and glycol ethers (if present).
7-light load of table protects agent formulation
* B indicates excess water
Table 8-general cleaning formulation
Table 9-bathroom cleaner preparation
By removing part water from preparation, remaining raw material is concentrated, water-base preparation concentrate is prepared.It then, can be before using by institute
Concentrate dilution is obtained to return to using concentration.Consumer be located at reception area cleaning and disinfection provide industry, generally use 5 times and
10 times of concentrates.Concentrate caters to the need in these industries, because reducing transportation cost and saving memory space.Table 10 illustrates this
Invent the example concentrate formulation in an embodiment.
10-concentrate formulation of table
Comparative Example
It tests a variety of polymerizable compounds using EPA 01-1A regulations and provides and energy is reduced to the continued biological load of clostridium perfringen
Power.Before through overtesting, keep 50 each preparations of μ L dry on glass carrier.Each experiment is carried out in the presence of 5% FBS.Such as table 11
Shown in , polyoxazolines and quaternary ammonium combination the remaining disinfection benefit of collaboration is provided.
Table 11
* it indicates due to bad organoleptic not test (N.T.)
Therefore, those skilled in the art should be easily understood that, the present composition and method allow wide range of applications and purposes.Ability
The technical staff in domain previously mentioned can be clearly visible by the disclosure and in the case where not departing from its original intention or range or rationally propose this
Many embodiments and adaptation and many variations, modification other than text is described and suitable arrangement.
Therefore, although describing the present composition and method about preferred embodiment detailed description, it should be appreciated that this
It is open only illustrate and exemplary, and made completely with permission disclosure only for providing.
It is disclosed above be not intended to or should not be construed as limit or in addition exclude other any such embodiments, adaptation,
Variation, modification and suitable arrangement.
Claims (21)
1. a kind of biomembrane sealing agent, the biomembrane sealing agent include:
Polymer adhesive, the wherein amplification or modification of polymer adhesive Wei oxazolines homopolymer or Ji Yu oxazoline homopolymers
Polymer;With
Component selected from Biocidal compounds, enzyme, antibody, bacteriophage or phage mixture and combinations thereof.
2. the biomembrane sealing agent of claim 1, Zhong Suo Shu oxazoline homopolymers have structure:
Wherein
R1For hydrogen, alkyl, alkenyl, alkoxy, alkyl amino, alkynyl, allyl, amino, anilino-, aryl, benzyl, carboxyl, carboxylic
Base alkyl, carboxyalkenyl, cyano, glycosyl, halogenated, hydroxyl, first sulphur acid oxazoline, first benzene sulphur acid oxazoline, trifluoro methylsulphur
Suan oxazolines, Jia Gui Wan oxazolins, phenol, poly-alkoxyl, quaternary ammonium, mercaptan or thioether group;
R2For hydrogen, alkyl, alkenyl, alkoxy, alkyl amino, alkynyl, allyl, amino, anilino-, aryl, benzyl, carboxyl, carboxylic
Base alkyl, carboxyalkenyl, cyano, glycosyl, halogenated, hydroxyl, first sulphur acid oxazoline, first benzene sulphur acid oxazoline, trifluoro methylsulphur
Suan oxazolines, Jia Gui Wan oxazolins, phenol, poly-alkoxyl, quaternary ammonium, mercaptan or thioether group or macrocyclic structure;
R3For hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxy alkyl or perfluoroalkyl;And
N is in the range of 1 to 1,000,000.
3. the biomembrane sealing agent of claim 1, wherein the base in oxazoline homopolymer amplification or polymer-modified have
Structure:
Wherein
R1For hydrogen, alkyl, alkenyl, alkoxy, alkyl amino, alkynyl, allyl, amino, anilino-, aryl, benzyl, carboxyl, carboxylic
Base alkyl, carboxyalkenyl, cyano, glycosyl, halogenated, hydroxyl, first sulphur acid oxazoline, first benzene sulphur acid oxazoline, trifluoro methylsulphur
Suan oxazolines, Jia Gui Wan oxazolins, phenol, poly-alkoxyl, quaternary ammonium, mercaptan or thioether group;
R3For hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxy alkyl or perfluoroalkyl;
N is in the range of 1 to 1,000,000;
B is the monomeric repeating unit for being connected to Gong polymers Zhong oxazolines;And
M is in the range of 0 to 500,000.
4. the biomembrane sealing agent of claim 3, wherein B are the aziridine having following structure:
Wherein
R1For hydrogen, alkyl, alkenyl, alkoxy, alkyl amino, alkynyl, allyl, amino, anilino-, aryl, benzyl, carboxyl, carboxylic
Base alkyl, carboxyalkenyl, cyano, glycosyl, halogenated, hydroxyl, first sulphur acid oxazoline, first benzene sulphur acid oxazoline, trifluoro methylsulphur
Suan oxazolines, Jia Gui Wan oxazolins, phenol, poly-alkoxyl, quaternary ammonium, mercaptan or thioether group;
R2For hydrogen, alkyl, alkenyl, alkoxy, alkyl amino, alkynyl, allyl, amino, anilino-, aryl, benzyl, carboxyl, carboxylic
Base alkyl, carboxyalkenyl, cyano, glycosyl, halogenated, hydroxyl, first sulphur acid oxazoline, first benzene sulphur acid oxazoline, trifluoro methylsulphur
Suan oxazolines, Jia Gui Wan oxazolins, phenol, poly-alkoxyl, quaternary ammonium, mercaptan or thioether group or macrocyclic structure;
R3For hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxy alkyl or perfluoroalkyl;
R4For hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxy alkyl or perfluoroalkyl;
M is in the range of 0 to 500,000;And
N is in the range of 1 to 1,000,000.
5. the biomembrane sealing agent of claim 3, wherein B have following structure:
Wherein
R1For hydrogen, alkyl, alkenyl, alkoxy, alkyl amino, alkynyl, allyl, amino, anilino-, aryl, benzyl, carboxyl, carboxylic
Base alkyl, carboxyalkenyl, cyano, glycosyl, halogenated, hydroxyl, first sulphur acid oxazoline, first benzene sulphur acid oxazoline, trifluoro methylsulphur
Suan oxazolines, Jia Gui Wan oxazolins, phenol, poly-alkoxyl, quaternary ammonium, mercaptan or thioether group;
R2For hydrogen, alkyl, alkenyl, alkoxy, alkyl amino, alkynyl, allyl, amino, anilino-, aryl, benzyl, carboxyl, carboxylic
Base alkyl, carboxyalkenyl, cyano, glycosyl, halogenated, hydroxyl, first sulphur acid oxazoline, first benzene sulphur acid oxazoline, trifluoro methylsulphur
Suan oxazolines, Jia Gui Wan oxazolins, phenol, poly-alkoxyl, quaternary ammonium, mercaptan or thioether group or macrocyclic structure;
R3For hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxy alkyl or perfluoroalkyl;
R4For hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxy alkyl or perfluoroalkyl;
R5For hydrogen, methyl, ethyl, propyl or another type of alkyl;
M is in the range of 0 to 500,000;
N is in the range of 1 to 1,000,000;And
Anion X-For halogen, sulfonate radical, sulfate radical, phosphonate radical, phosphate radical, carbonate/bicarbonate, hydroxyl or carboxylate radical.
6. the biomembrane sealing agent of claim 3, wherein B are being changed with diallyl dimethyl ammoniumchloride of having following structure
The polyethyloxazoline of property:
Wherein
R1For hydrogen, alkyl, alkenyl, alkoxy, alkyl amino, alkynyl, allyl, amino, anilino-, aryl, benzyl, carboxyl, carboxylic
Base alkyl, carboxyalkenyl, cyano, glycosyl, halogenated, hydroxyl, first sulphur acid oxazoline, first benzene sulphur acid oxazoline, trifluoro methylsulphur
Suan oxazolines, Jia Gui Wan oxazolins, phenol, poly-alkoxyl, quaternary ammonium, mercaptan or thioether group;
R2For short-chain alkyl;
R3For short-chain alkyl;
R4For hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxy alkyl or perfluoroalkyl;
M is in the range of 0 to 500,000;
N is in the range of 1 to 1,000,000;And
Anion X-For halogen, sulfonate radical, sulfate radical, phosphonate radical, phosphate radical, carbonate, bicarbonate radical, hydroxyl or carboxylate radical.
7. the biomembrane sealing agent of claim 3, wherein B are selected from diallyldimethylammonium chloride, styrene, methoxybenzene
The alkene of ethylene, methoxy-ethylene or another alkene.
8. the biomembrane sealing agent of claim 1, wherein the polymer adhesive is prepared with ethyl oxazoline monomer.
9. the biomembrane sealing agent of claim 8, wherein ethyl oxazoline is made to be copolymerized with heterocyclic monomer.
10. the biomembrane sealing agent of claim 1, wherein the polymer adhesive utilizes the oxazoline on polymer backbone
Side group.
11. the biomembrane sealing agent of claim 10, wherein the polymer backbone is acrylic compounds or styrene-based polymer,
Or the copolymer containing acrylic compounds or styrene.
12. the biomembrane sealing agent of claim 1, wherein the biocide preparation is liquid form.
13. the biomembrane sealing agent of claim 1, wherein the Biocidal compounds are selected from quaternary ammonium compound, citric acid, amino
Sulfonic acid, glycolic, lactic acid, lauric acid and capric acid, silane quaternary salt, triclosan, zinc pyrithione, metal salt, metal oxide,
Phenol, plant material, halogen, peroxide, heterocycle antimicrobial, aldehyde, alcohol and combinations thereof.
14. the biomembrane sealing agent of claim 13, wherein the quaternary ammonium compound has structure:
Wherein
R1For alkyl, alkoxy or aryl, with or without hetero atom, or saturation or unsaturated;
R2For alkyl, alkoxy or aryl, with or without hetero atom, or saturation or unsaturated;
R3For alkyl, alkoxy or aryl, with or without hetero atom, or saturation or unsaturated;
R4For alkyl, alkoxy or aryl, with or without hetero atom, or saturation or unsaturated;
Anion X-For halogen, sulfonate radical, sulfate radical, phosphonate radical, phosphate radical, carbonate, bicarbonate radical, hydroxyl or carboxylate radical.
15. the biomembrane sealing agent of claim 13, wherein the quaternary ammonium compound be selected from n alkyl dimethyl benzyl ammonium chloride,
Di-n-octyl alkyl dimethyl ammonium chloride, dodecyl dimethyl ammonium chloride, saccharin n alkyl dimethyl benzyl ammonium, 3- (trimethoxies
Silicyl) propyl-dimethyl octadecyl ammonium chloride and combinations thereof.
16. the biomembrane sealing agent of claim 13, wherein the quaternary ammonium compound is present in composition, including:Alkyl
Dimethyl benzyl ammonium chloride, n-octyl decyl dimethyl ammonium chloride, two positive decyl alkyl dimethyl ammonium chlorides and di-n-octyl dimethyl
Ammonium chloride.
17. the biomembrane sealing agent of claim 13, wherein the quaternary ammonium compound is the type of polymer having following structure:
Or
Wherein
R1For hydrogen, methyl, ethyl, propyl or other carbon alkyl;
R2For hydrogen, methyl, ethyl, propyl or other carbon alkyl;
R3For methylene, ethylidene, propylidene or other alkylidene linkers;
R4For methylene, ethylidene, propylidene or other alkylidene linkers;
R5For hydrogen, methyl, ethyl, propyl or other carbon alkyl;
R6For hydrogen, methyl, ethyl, propyl or other carbon alkyl;And
N is in the range of 2 to 10,000.
18. the biomembrane sealing agent of claim 17, wherein the type of polymer is cationic polymer.
19. the biomembrane sealing agent of claim 18, wherein the cationic polymer is to be obtained from dimethyl amine and epichlorohydrin
Polyamine.
20. the biomembrane sealing agent of claim 13, wherein the quaternary ammonium compound is diallyl dimethyl ammoniumchloride, gathers
DADMAC or the compound for including biguanide moiety in the molecule.
21. a kind of application method, the method includes:
Biomembrane is sealed with polymer adhesive,
The wherein described polymer adhesive is oxazoline homopolymer or base in the amplification of oxazoline homopolymer or polymer-modified.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/949,046 US10834922B2 (en) | 2014-11-26 | 2015-11-23 | Surface disinfectant with residual biocidal property |
| US14/949046 | 2015-11-23 | ||
| US15/162,094 US10842147B2 (en) | 2014-11-26 | 2016-05-23 | Surface disinfectant with residual biocidal property |
| US15/162094 | 2016-05-23 | ||
| PCT/US2016/033891 WO2017091251A1 (en) | 2015-11-23 | 2016-05-24 | Surface disinfectant with residual biocidal property |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108697082A true CN108697082A (en) | 2018-10-23 |
Family
ID=58763475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680079606.6A Pending CN108697082A (en) | 2015-11-23 | 2016-05-24 | Surface disinfection agent with remaining biocidal properties |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP3379932A4 (en) |
| JP (1) | JP6966438B2 (en) |
| CN (1) | CN108697082A (en) |
| CA (1) | CA3005601A1 (en) |
| MX (1) | MX2018006391A (en) |
| WO (1) | WO2017091251A1 (en) |
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| US10842147B2 (en) | 2014-11-26 | 2020-11-24 | Microban Products Company | Surface disinfectant with residual biocidal property |
| US10925281B2 (en) | 2014-11-26 | 2021-02-23 | Microban Products Company | Surface disinfectant with residual biocidal property |
| US11033023B2 (en) | 2014-11-26 | 2021-06-15 | Microban Products Company | Surface disinfectant with residual biocidal property |
| US11026418B2 (en) | 2014-11-26 | 2021-06-08 | Microban Products Company | Surface disinfectant with residual biocidal property |
| US11503824B2 (en) | 2016-05-23 | 2022-11-22 | Microban Products Company | Touch screen cleaning and protectant composition |
| JP2020523293A (en) * | 2017-06-16 | 2020-08-06 | ダブリュー．エム． バアー アンド カンパニー， インコーポレイテッド | Surface germicide with residual germicidal properties |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2017091251A1 (en) | 2017-06-01 |
| CA3005601A1 (en) | 2017-06-01 |
| RU2018122622A (en) | 2019-12-25 |
| MX2018006391A (en) | 2019-02-14 |
| JP6966438B2 (en) | 2021-11-17 |
| JP2018534331A (en) | 2018-11-22 |
| EP3379932A4 (en) | 2019-05-01 |
| EP3379932A1 (en) | 2018-10-03 |
| RU2018122622A3 (en) | 2019-12-25 |
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