CN108685945A - Oral liquid containing iron and vitamin C and preparation method thereof - Google Patents

Oral liquid containing iron and vitamin C and preparation method thereof Download PDF

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Publication number
CN108685945A
CN108685945A CN201810959705.4A CN201810959705A CN108685945A CN 108685945 A CN108685945 A CN 108685945A CN 201810959705 A CN201810959705 A CN 201810959705A CN 108685945 A CN108685945 A CN 108685945A
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CN
China
Prior art keywords
parts
vitamin
victoria
purified water
oral solution
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Withdrawn
Application number
CN201810959705.4A
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Chinese (zh)
Inventor
苏玉增
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Anhui Tianma Biotechnology Co ltd
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Anhui Tianma Biotechnology Co ltd
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Priority to CN201810959705.4A priority Critical patent/CN108685945A/en
Publication of CN108685945A publication Critical patent/CN108685945A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/26Iron; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses an oral liquid containing iron and vitamin C, which is characterized by comprising the following raw materials in parts by weight: 60-80 parts of ferrous vitamin C, 10-20 parts of flavoring agent and purified water subjected to nitrogen saturation treatment to be supplemented to 1000 parts, and the invention has the beneficial effects that: the liquid phase of the oral liquid is purified water after nitrogen saturation treatment, can reduce the oxidation phenomenon of vitamin C and derivatives thereof in the preparation process, is beneficial to the metabolism of tyrosine and tryptophan in amino acid of a human body, is beneficial to improving pigmentation and prolonging the life of the human body; is helpful for improving iron deficiency anemia, and promoting the utilization of vitamin C, iron, calcium, etc. by human body.

Description

A kind of oral solution and preparation method thereof of iron content and Victoria C
Technical field
The present invention relates to a kind of oral solution, the oral solution and preparation method thereof of specifically a kind of iron content and Victoria C.
Background technology
Vitamin C (i.e. L-AA) can participate in internal a variety of metabolic processes, and enzyme is helped to convert cholesterol to cholic acid Excretion, thus lower the brittleness of capillary, increase body resistivity;Clinically it is widely used in preventing and treating bad blood The auxiliary treatment of disease, various acute and chronic communicable diseases and purpura etc..
Iron is the material base of hematopoiesis, is the activator for the essential component and enzyme for constituting hemoglobin.Present children Because preferred diet and environment missing frequently result in iron content deficiency.Iron deficiency can often lead to entire metabolic disturbance, gastrointestinal tract Hypofunction, eye conjunctiva and nail are reduced without color, immune function.
The oral solution of existing benefit iron and replenishing vitamins C often will appear oxidation or decomposing phenomenon in preparation process.
Invention content
The purpose of the present invention is to provide the oral solutions and preparation method thereof of a kind of iron content and Victoria C, to solve above-mentioned background The problem of being proposed in technology.
To achieve the above object, the present invention provides the following technical solutions:
A kind of oral solution of iron content and Victoria C, includes the raw material of following composition by weight:60-80 parts of vitamin C ferrous iron, dimension life C10-20 parts plain, 10-20 parts of corrigent, the purified water polishing after nitrogen saturated process are to 1000 parts.
As a further solution of the present invention:Include the raw material of following composition by weight:65-75 parts of vitamin C ferrous iron, dimension life C14-16 parts plain, 14-16 parts of corrigent, the purified water polishing after nitrogen saturated process are to 1000 parts.
As further scheme of the invention:Include the raw material of following composition by weight:Vitamin C is 70 parts ferrous, dimension is given birth to C15 parts plain, 15 parts of corrigent, the purified water polishing after nitrogen saturated process are to 1000 parts.
As further scheme of the invention:The corrigent is one in steviol glycoside, orange essence and sorbierite Kind is several.
A kind of preparation method of the oral solution of iron content and Victoria C, includes the following steps:
S1 weighs the vitamin C ferrous iron and vitamin C of formula ratio, is put into micronizer and crushes, obtain grain size 20-40 μm of powder;
S2 takes above-mentioned powder to be placed in container, and the purified water after nitrogen saturated process of 80% formula ratio, stirring is added So that it is fully dissolved, it is to be dissolved fully after, continuously add remaining purified water and corrigent after nitrogen saturated process, continue Stirring is to being completely dissolved;
S3, by step S2 handy 0.2 μm of miillpore filter be filtered, gained carries out filling envelope under nitrogen protection Lid is carrying out sterilization treatment later.
As further scheme of the invention:Grinding time 4-6 minutes in step S1, and it is sieved after being pulverized, Yu Zhe Continue to put into micronizer.
Compared with prior art, the beneficial effects of the invention are as follows:The liquid phase of this oral solution is after nitrogen saturated process Purified water can reduce the oxidative phenomena of vitamin C and its derivative in preparation process, contribute to tyrosine in human amino acid With the metabolism of tryptophan, helps to improve pigmentation, extend the human body service life;Help to improve hypoferric anemia, promotes human body Utilization to vitamin C, iron, calcium etc..
Specific implementation mode
The technical solution of this patent is described in more detail With reference to embodiment.
Embodiment 1
A kind of preparation method of the oral solution of iron content and Victoria C, includes the following steps:
S1 weighs vitamin C ferrous 60 parts and 10 parts of vitamin C, is put into micronizer and crushes, grinding time It 4 minutes, is sieved after being pulverized, remaining person continues to put into micronizer, finally obtains the powder of 20-40 μm of grain size;
S2 takes above-mentioned powder to be placed in container, and the purified water after nitrogen saturated process of 80% formula ratio, stirring is added So that it is fully dissolved, it is to be dissolved fully after, continuously add 10 parts of the remaining purified water after nitrogen saturated process and corrigent, Continue stirring to being completely dissolved;
S3, by step S2 handy 0.2 μm of miillpore filter be filtered, gained carries out filling envelope under nitrogen protection Lid is carrying out sterilization treatment, in order to prevent vitamin C oxygenolysis caused by prolonged height later, in sterilizing It is rapidly decreased to room temperature using 100 DEG C of steam sterilizing 15 minutes, then by temperature.
Embodiment 2
A kind of preparation method of the oral solution of iron content and Victoria C, includes the following steps:
S1 weighs vitamin C ferrous 80 parts and 0 part of Catergen, is put into micronizer and crushes, grinding time It 6 minutes, is sieved after being pulverized, remaining person continues to put into micronizer, finally obtains the powder of 20-40 μm of grain size;
S2 takes above-mentioned powder to be placed in container, and the purified water after nitrogen saturated process of 80% formula ratio, stirring is added So that it is fully dissolved, it is to be dissolved fully after, continuously add 20 parts of the remaining purified water after nitrogen saturated process and corrigent, Continue stirring to being completely dissolved;
S3, by step S2 handy 0.2 μm of miillpore filter be filtered, gained carries out filling envelope under nitrogen protection Lid is carrying out sterilization treatment, in order to prevent vitamin C oxygenolysis caused by prolonged height later, in sterilizing It is rapidly decreased to room temperature using 100 DEG C of steam sterilizing 15 minutes, then by temperature.
Embodiment 2
A kind of preparation method of the oral solution of iron content and Victoria C, includes the following steps:
S1 weighs vitamin C ferrous 70 parts and 15 parts of vitamin C, is put into micronizer and crushes, grinding time It 5 minutes, is sieved after being pulverized, remaining person continues to put into micronizer, finally obtains the powder of 20-40 μm of grain size;
S2 takes above-mentioned powder to be placed in container, and the purified water after nitrogen saturated process of 80% formula ratio, stirring is added So that it is fully dissolved, it is to be dissolved fully after, continuously add 15 parts of the remaining purified water after nitrogen saturated process and corrigent, Continue stirring to being completely dissolved;
S3, by step S2 handy 0.2 μm of miillpore filter be filtered, gained carries out filling envelope under nitrogen protection Lid is carrying out sterilization treatment, in order to prevent vitamin C oxygenolysis caused by prolonged height later, in sterilizing It is rapidly decreased to room temperature using 100 DEG C of steam sterilizing 15 minutes, then by temperature.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power Profit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art The other embodiment being appreciated that.

Claims (6)

1. the oral solution of a kind of iron content and Victoria C, which is characterized in that include the raw material of following composition by weight:Vitamin C ferrous iron 60- 80 parts, 10-20 parts of vitamin C, 10-20 parts of corrigent, the purified water polishing after nitrogen saturated process is to 1000 parts.
2. the oral solution of a kind of iron content and Victoria C according to claim 1, which is characterized in that including following composition by weight Raw material:65-75 parts of vitamin C ferrous iron, 14-16 parts of vitamin C, 14-16 parts of corrigent, the purifying after nitrogen saturated process Water polishing is to 1000 parts.
3. the oral solution of a kind of iron content and Victoria C according to claim 1, which is characterized in that including following composition by weight Raw material:70 parts of vitamin C ferrous iron, 15 parts of vitamin C, 15 parts of corrigent, the purified water polishing after nitrogen saturated process are extremely 1000 parts.
4. according to the oral solution of any a kind of iron content and Victoria C of claim 1-3, which is characterized in that the corrigent is One or more of steviol glycoside, orange essence and sorbierite.
5. a kind of preparation method of the oral solution of iron content as described in any one of claims 1-3 and Victoria C, which is characterized in that including Following steps:
S1 weighs the vitamin C ferrous iron and vitamin C of formula ratio, is put into micronizer and crushes, obtain grain size 20- 40 μm of powder;
S2 takes above-mentioned powder to be placed in container, and the purified water after nitrogen saturated process of 80% formula ratio is added, and stirring makes it Fully dissolving, it is to be dissolved fully after, continuously add remaining purified water and corrigent after nitrogen saturated process, continue to stir To being completely dissolved;
S3, by step S2 handy 0.2 μm of miillpore filter be filtered, gained carries out filling and capping under nitrogen protection, it Carrying out sterilization treatment afterwards.
6. the preparation method of the oral solution of iron content according to claim 5 and Victoria C, which is characterized in that crushed in step S1 Time 4-6 minute, and be sieved after being pulverized, remaining person continues to put into micronizer.
CN201810959705.4A 2018-08-17 2018-08-17 Oral liquid containing iron and vitamin C and preparation method thereof Withdrawn CN108685945A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810959705.4A CN108685945A (en) 2018-08-17 2018-08-17 Oral liquid containing iron and vitamin C and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810959705.4A CN108685945A (en) 2018-08-17 2018-08-17 Oral liquid containing iron and vitamin C and preparation method thereof

Publications (1)

Publication Number Publication Date
CN108685945A true CN108685945A (en) 2018-10-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810959705.4A Withdrawn CN108685945A (en) 2018-08-17 2018-08-17 Oral liquid containing iron and vitamin C and preparation method thereof

Country Status (1)

Country Link
CN (1) CN108685945A (en)

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Application publication date: 20181023

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