CN108685945A - Oral liquid containing iron and vitamin C and preparation method thereof - Google Patents
Oral liquid containing iron and vitamin C and preparation method thereof Download PDFInfo
- Publication number
- CN108685945A CN108685945A CN201810959705.4A CN201810959705A CN108685945A CN 108685945 A CN108685945 A CN 108685945A CN 201810959705 A CN201810959705 A CN 201810959705A CN 108685945 A CN108685945 A CN 108685945A
- Authority
- CN
- China
- Prior art keywords
- parts
- vitamin
- victoria
- purified water
- oral solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title claims abstract description 58
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims abstract description 42
- 235000019154 vitamin C Nutrition 0.000 title claims abstract description 30
- 239000011718 vitamin C Substances 0.000 title claims abstract description 30
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 title claims abstract description 29
- 229930003268 Vitamin C Natural products 0.000 title claims abstract description 29
- 229910052742 iron Inorganic materials 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000007788 liquid Substances 0.000 title abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 48
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000008213 purified water Substances 0.000 claims abstract description 18
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims description 17
- 229920006395 saturated elastomer Polymers 0.000 claims description 17
- 229940100688 oral solution Drugs 0.000 claims description 16
- 230000001954 sterilising effect Effects 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 6
- 238000005498 polishing Methods 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 239000004383 Steviol glycoside Substances 0.000 claims description 2
- 229930182488 steviol glycoside Natural products 0.000 claims description 2
- 235000019411 steviol glycoside Nutrition 0.000 claims description 2
- 150000008144 steviol glycosides Chemical class 0.000 claims description 2
- 235000019202 steviosides Nutrition 0.000 claims description 2
- 230000009286 beneficial effect Effects 0.000 abstract description 4
- 230000004060 metabolic process Effects 0.000 abstract description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract description 2
- 150000001413 amino acids Chemical class 0.000 abstract description 2
- 239000011575 calcium Substances 0.000 abstract description 2
- 229910052791 calcium Inorganic materials 0.000 abstract description 2
- 239000007791 liquid phase Substances 0.000 abstract description 2
- 230000003647 oxidation Effects 0.000 abstract description 2
- 238000007254 oxidation reaction Methods 0.000 abstract description 2
- 230000019612 pigmentation Effects 0.000 abstract description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract description 2
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
- 238000000227 grinding Methods 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 3
- 230000002035 prolonged effect Effects 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
- 239000004380 Cholic acid Substances 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 206010022971 Iron Deficiencies Diseases 0.000 description 1
- 206010037549 Purpura Diseases 0.000 description 1
- 241001672981 Purpura Species 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 229960002471 cholic acid Drugs 0.000 description 1
- 235000019416 cholic acid Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 210000000795 conjunctiva Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an oral liquid containing iron and vitamin C, which is characterized by comprising the following raw materials in parts by weight: 60-80 parts of ferrous vitamin C, 10-20 parts of flavoring agent and purified water subjected to nitrogen saturation treatment to be supplemented to 1000 parts, and the invention has the beneficial effects that: the liquid phase of the oral liquid is purified water after nitrogen saturation treatment, can reduce the oxidation phenomenon of vitamin C and derivatives thereof in the preparation process, is beneficial to the metabolism of tyrosine and tryptophan in amino acid of a human body, is beneficial to improving pigmentation and prolonging the life of the human body; is helpful for improving iron deficiency anemia, and promoting the utilization of vitamin C, iron, calcium, etc. by human body.
Description
Technical field
The present invention relates to a kind of oral solution, the oral solution and preparation method thereof of specifically a kind of iron content and Victoria C.
Background technology
Vitamin C (i.e. L-AA) can participate in internal a variety of metabolic processes, and enzyme is helped to convert cholesterol to cholic acid
Excretion, thus lower the brittleness of capillary, increase body resistivity;Clinically it is widely used in preventing and treating bad blood
The auxiliary treatment of disease, various acute and chronic communicable diseases and purpura etc..
Iron is the material base of hematopoiesis, is the activator for the essential component and enzyme for constituting hemoglobin.Present children
Because preferred diet and environment missing frequently result in iron content deficiency.Iron deficiency can often lead to entire metabolic disturbance, gastrointestinal tract
Hypofunction, eye conjunctiva and nail are reduced without color, immune function.
The oral solution of existing benefit iron and replenishing vitamins C often will appear oxidation or decomposing phenomenon in preparation process.
Invention content
The purpose of the present invention is to provide the oral solutions and preparation method thereof of a kind of iron content and Victoria C, to solve above-mentioned background
The problem of being proposed in technology.
To achieve the above object, the present invention provides the following technical solutions:
A kind of oral solution of iron content and Victoria C, includes the raw material of following composition by weight:60-80 parts of vitamin C ferrous iron, dimension life
C10-20 parts plain, 10-20 parts of corrigent, the purified water polishing after nitrogen saturated process are to 1000 parts.
As a further solution of the present invention:Include the raw material of following composition by weight:65-75 parts of vitamin C ferrous iron, dimension life
C14-16 parts plain, 14-16 parts of corrigent, the purified water polishing after nitrogen saturated process are to 1000 parts.
As further scheme of the invention:Include the raw material of following composition by weight:Vitamin C is 70 parts ferrous, dimension is given birth to
C15 parts plain, 15 parts of corrigent, the purified water polishing after nitrogen saturated process are to 1000 parts.
As further scheme of the invention:The corrigent is one in steviol glycoside, orange essence and sorbierite
Kind is several.
A kind of preparation method of the oral solution of iron content and Victoria C, includes the following steps:
S1 weighs the vitamin C ferrous iron and vitamin C of formula ratio, is put into micronizer and crushes, obtain grain size
20-40 μm of powder;
S2 takes above-mentioned powder to be placed in container, and the purified water after nitrogen saturated process of 80% formula ratio, stirring is added
So that it is fully dissolved, it is to be dissolved fully after, continuously add remaining purified water and corrigent after nitrogen saturated process, continue
Stirring is to being completely dissolved;
S3, by step S2 handy 0.2 μm of miillpore filter be filtered, gained carries out filling envelope under nitrogen protection
Lid is carrying out sterilization treatment later.
As further scheme of the invention:Grinding time 4-6 minutes in step S1, and it is sieved after being pulverized, Yu Zhe
Continue to put into micronizer.
Compared with prior art, the beneficial effects of the invention are as follows:The liquid phase of this oral solution is after nitrogen saturated process
Purified water can reduce the oxidative phenomena of vitamin C and its derivative in preparation process, contribute to tyrosine in human amino acid
With the metabolism of tryptophan, helps to improve pigmentation, extend the human body service life;Help to improve hypoferric anemia, promotes human body
Utilization to vitamin C, iron, calcium etc..
Specific implementation mode
The technical solution of this patent is described in more detail With reference to embodiment.
Embodiment 1
A kind of preparation method of the oral solution of iron content and Victoria C, includes the following steps:
S1 weighs vitamin C ferrous 60 parts and 10 parts of vitamin C, is put into micronizer and crushes, grinding time
It 4 minutes, is sieved after being pulverized, remaining person continues to put into micronizer, finally obtains the powder of 20-40 μm of grain size;
S2 takes above-mentioned powder to be placed in container, and the purified water after nitrogen saturated process of 80% formula ratio, stirring is added
So that it is fully dissolved, it is to be dissolved fully after, continuously add 10 parts of the remaining purified water after nitrogen saturated process and corrigent,
Continue stirring to being completely dissolved;
S3, by step S2 handy 0.2 μm of miillpore filter be filtered, gained carries out filling envelope under nitrogen protection
Lid is carrying out sterilization treatment, in order to prevent vitamin C oxygenolysis caused by prolonged height later, in sterilizing
It is rapidly decreased to room temperature using 100 DEG C of steam sterilizing 15 minutes, then by temperature.
Embodiment 2
A kind of preparation method of the oral solution of iron content and Victoria C, includes the following steps:
S1 weighs vitamin C ferrous 80 parts and 0 part of Catergen, is put into micronizer and crushes, grinding time
It 6 minutes, is sieved after being pulverized, remaining person continues to put into micronizer, finally obtains the powder of 20-40 μm of grain size;
S2 takes above-mentioned powder to be placed in container, and the purified water after nitrogen saturated process of 80% formula ratio, stirring is added
So that it is fully dissolved, it is to be dissolved fully after, continuously add 20 parts of the remaining purified water after nitrogen saturated process and corrigent,
Continue stirring to being completely dissolved;
S3, by step S2 handy 0.2 μm of miillpore filter be filtered, gained carries out filling envelope under nitrogen protection
Lid is carrying out sterilization treatment, in order to prevent vitamin C oxygenolysis caused by prolonged height later, in sterilizing
It is rapidly decreased to room temperature using 100 DEG C of steam sterilizing 15 minutes, then by temperature.
Embodiment 2
A kind of preparation method of the oral solution of iron content and Victoria C, includes the following steps:
S1 weighs vitamin C ferrous 70 parts and 15 parts of vitamin C, is put into micronizer and crushes, grinding time
It 5 minutes, is sieved after being pulverized, remaining person continues to put into micronizer, finally obtains the powder of 20-40 μm of grain size;
S2 takes above-mentioned powder to be placed in container, and the purified water after nitrogen saturated process of 80% formula ratio, stirring is added
So that it is fully dissolved, it is to be dissolved fully after, continuously add 15 parts of the remaining purified water after nitrogen saturated process and corrigent,
Continue stirring to being completely dissolved;
S3, by step S2 handy 0.2 μm of miillpore filter be filtered, gained carries out filling envelope under nitrogen protection
Lid is carrying out sterilization treatment, in order to prevent vitamin C oxygenolysis caused by prolonged height later, in sterilizing
It is rapidly decreased to room temperature using 100 DEG C of steam sterilizing 15 minutes, then by temperature.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiment being appreciated that.
Claims (6)
1. the oral solution of a kind of iron content and Victoria C, which is characterized in that include the raw material of following composition by weight:Vitamin C ferrous iron 60-
80 parts, 10-20 parts of vitamin C, 10-20 parts of corrigent, the purified water polishing after nitrogen saturated process is to 1000 parts.
2. the oral solution of a kind of iron content and Victoria C according to claim 1, which is characterized in that including following composition by weight
Raw material:65-75 parts of vitamin C ferrous iron, 14-16 parts of vitamin C, 14-16 parts of corrigent, the purifying after nitrogen saturated process
Water polishing is to 1000 parts.
3. the oral solution of a kind of iron content and Victoria C according to claim 1, which is characterized in that including following composition by weight
Raw material:70 parts of vitamin C ferrous iron, 15 parts of vitamin C, 15 parts of corrigent, the purified water polishing after nitrogen saturated process are extremely
1000 parts.
4. according to the oral solution of any a kind of iron content and Victoria C of claim 1-3, which is characterized in that the corrigent is
One or more of steviol glycoside, orange essence and sorbierite.
5. a kind of preparation method of the oral solution of iron content as described in any one of claims 1-3 and Victoria C, which is characterized in that including
Following steps:
S1 weighs the vitamin C ferrous iron and vitamin C of formula ratio, is put into micronizer and crushes, obtain grain size 20-
40 μm of powder;
S2 takes above-mentioned powder to be placed in container, and the purified water after nitrogen saturated process of 80% formula ratio is added, and stirring makes it
Fully dissolving, it is to be dissolved fully after, continuously add remaining purified water and corrigent after nitrogen saturated process, continue to stir
To being completely dissolved;
S3, by step S2 handy 0.2 μm of miillpore filter be filtered, gained carries out filling and capping under nitrogen protection, it
Carrying out sterilization treatment afterwards.
6. the preparation method of the oral solution of iron content according to claim 5 and Victoria C, which is characterized in that crushed in step S1
Time 4-6 minute, and be sieved after being pulverized, remaining person continues to put into micronizer.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810959705.4A CN108685945A (en) | 2018-08-17 | 2018-08-17 | Oral liquid containing iron and vitamin C and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810959705.4A CN108685945A (en) | 2018-08-17 | 2018-08-17 | Oral liquid containing iron and vitamin C and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108685945A true CN108685945A (en) | 2018-10-23 |
Family
ID=63841365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201810959705.4A Withdrawn CN108685945A (en) | 2018-08-17 | 2018-08-17 | Oral liquid containing iron and vitamin C and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108685945A (en) |
-
2018
- 2018-08-17 CN CN201810959705.4A patent/CN108685945A/en not_active Withdrawn
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WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181023 |
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