CN108671198A - 治疗失眠的药物及其制备方法 - Google Patents

治疗失眠的药物及其制备方法 Download PDF

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CN108671198A
CN108671198A CN201810745990.XA CN201810745990A CN108671198A CN 108671198 A CN108671198 A CN 108671198A CN 201810745990 A CN201810745990 A CN 201810745990A CN 108671198 A CN108671198 A CN 108671198A
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刘熙安
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Abstract

本发明公开了一种治疗失眠的药物，由以重量份为单位，制成其有效成分的原料药为：竹茹30~60份，枳实20~40份，陈皮40~60份，法半夏30~60份，茯神35~65份，黄连25~45份，牡丹皮20~40份，栀子25~45份，珍珠母30~40份，炙甘草25~45份，柏子仁20~40份，决明子20~40份，阿胶20~30份，桑葚25~45份，夜交藤15~40份，大枣30~50份，莲子15~30份，何首乌20~40份，远志30~60份，郁金15~35份，龙眼15~30份，龙骨20~35份，合欢花30~45份，百合25~45份。本发明由中草药配制而成，可以从根本治愈失眠症状，达到安神益智、养阴润肺、清心安神、补益心脾、抗惊镇静、清热燥湿，泻火解毒、疏肝解郁之功效，经临床试验，效果极好，易于推广。

Description

治疗失眠的药物及其制备方法
一、技术领域
本发明涉及一种中草药，特别涉及一种治疗失眠的药物，以及该颗粒剂的制备方法，属于中药及其制备技术领域。
二、背景技术
常言道，“吃人参不如睡五更”，这句谚语道出了睡眠的真谛和重要性。日常生活中，失眠是一种常见病、多发病，其发病率非常高，危害性也非常大。但很多人却忽视了长期失眠的危害性，人的睡眠是一种正常的生理反应，是大脑神经活动的一部分。睡觉时，四肢停止了运动，全身肌肉放松，心跳减慢，呼吸深而长，全身都能够得到充分的放松和休息，只有睡眠充足才能保证第二天精力充沛，其他活动很难像睡眠在我们生活中起到这么大的作用。
市面上有很多治疗失眠的药物，很多失眠患者长期受失眠症的影响都会选择西医治疗，但是西医在治疗方面只能起到缓解的作用，且长期服用西药会有一定的依赖性，副作用极大；所以失眠症最好用中药来调理，但是现有的中药，很多未能达到预想的效果，其疗效不尽人意。
三、发明内容：
本发明所要解决的技术问题是：克服现有治疗技术中的不足，提供一种治疗失眠的药物药，由中草药配制而成，治疗效果好、无毒副作用，可以更有效、更迅速的疗失眠。
本发明为解决技术问题所采取的技术方案是:
一种治疗失眠的药物，由以重量份为单位，制成其有效成分的原料药为：竹茹30～60份，枳实20～40份，陈皮40～60份，法半夏30～60份，茯神35～65份，黄连25～45份，牡丹皮20～40份，栀子25～45份，珍珠母30～40份，炙甘草25～45份，柏子仁20～40份，决明子20～40份，阿胶20～30份，桑葚25～45份，夜交藤15～40份，大枣30～50份，莲子15～30份，何首乌20～40份，远志30～60份，郁金15～35份，龙眼15～30份，龙骨20～35份，合欢花30～45份，百合25～45份。
所述的治疗失眠的药物，由以重量份为单位，制成其有效成分的原料药为：竹茹45份，枳实30份，陈皮50份，法半夏45份，茯神50份，黄连35份，牡丹皮30份，栀子35份，珍珠母35份，炙甘草35份，柏子仁30份，决明子30份 ，阿胶25份，桑葚35份，夜交藤27份，大枣40份，莲子22份，何首乌30份，远志45份，郁金25份，龙眼22份，龙骨27份，合欢花37份，百合35份。
上面所述的治疗失眠的药物的剂型为颗粒剂。
所述的治疗失眠的药物的制备方法，其具体加工步骤如下：
A、称取所述重量份的各原料药混合在一起，加6倍量水浸泡30~40分钟，然后加热煎煮1.5小时，得煎煮液A和药渣A；
B、向药渣A中加入4倍量的水，加热煎煮1小时，得煎煮液B和药渣B；
C、向B中加入2倍量的水，加热煎煮40分钟，得煎煮液C和药渣C；
D、合并3次煎煮液，静止10小时后，过滤，得滤液A；
E、将滤液A蒸发浓缩致稠膏状，停止加热；
F、50-60°干燥后，粉碎至120目的药粉，分装、密封、包装，即得到治疗失眠症中药的颗粒剂。
本发明的积极有益效果如下：
1、本发明是治疗失眠的药物，是以祖国中医药学理论为基础，结合各种中药组分的机理，从医学宝库中筛选出具有养血安神、祛风通络、健脾宁心、疏肝理气等功效药物，该药物成分中:竹茹:味甘，性微寒，归肺、胃、心、胆经，具有清热化痰，除烦，止呕之功效；枳实：味苦，性温，归脾、胃、大肠经，具有破气除痞、化痰消积之功效；陈皮：味苦、辛，性温，归肺、脾经，具有理气健脾，燥湿化痰之功效；法半夏：味辛、性温，归脾、胃、肺经，具有燥湿化痰之功效；茯神：性温，味甘，归心、脾经，具有宁心，安神，利水之功效；黄连：性寒、味苦，具有清热燥湿，泻火解毒之功效；牡丹皮：味苦、辛，性微寒，归心、肝、肾经，具有清热凉血，活血化瘀之功效；栀子：味苦,性寒，归心、肺、胃、三焦经，具有护肝、利胆、降压、镇静、止血、消肿之功效；珍珠母：味咸，性凉，归心、肝经，具有滋肝阴、清肝火、安神魂，定惊痫，消热痞之功效；炙甘草：性平，味甘，归胃、心、肺、脾经，具有具有益气滋阴，通阳复脉之功效；柏子仁：味甘，性平，归心、肾、大肠经，具有养心安神，润肠通便，止汗之功效；决明子：味甘、苦，性寒，微咸，归肝、大肠经，具有清肝明目，润肠通便之功效；阿胶：味甘，性平，归肺、肝、肾经，具有滋阴补血，治血虚之功效；桑葚：味甘，性寒，具有补肝益肾、生津润燥、乌发明目之功效；夜交藤：味甘、微苦，性平，归心、肝经，具有养心安神，祛风通络之功效；大枣：味甘，性平，归脾、胃经，具有补中益气、补脾和胃、益气生津之功效；莲子：味甘、涩，性平，归脾、肾、心经，补脾止泻，止带，益肾涩精，养心安神之功效；何首乌：味苦甘涩，性微温，归肝、肾经，具有养血滋阴，润肠通便，截疟，祛风，解毒之功效；远志：味苦，性温，归心、肾、肺经，具有安神益智、祛痰、消肿之功效；郁金：性辛、苦，味寒，归肝、心、肺经，具有活血止痛，行气解郁，清心凉血，利胆退黄之功效；龙眼：味甘，性温，归心、脾经，具有补益心脾，养血安神；龙骨：性平，味甘，归心、肝、肾、大肠经，具有安神镇惊安神，敛汗固精，止血涩肠，生肌敛疮之功效；合欢花：味甘，性平，归心、脾经，具有舒郁，理气，安神，活络之功效；百合：味甘，性寒，归心，肺经，具有养阴润肺，清心安神之功效。
2、本发明将以上中药合用，达到安神益智、养阴润肺、清心安神、补益心脾、抗惊镇静、清热燥湿，泻火解毒、疏肝解郁之功效，其药效协同作用，可以从根本治愈失眠症状，从而达到标本兼治的作用。
3、本发明由各种中草药制备而成，重在治本，疗效快、效果好，且无毒副作用，经临床试验，效果极好，得到了患者的认可，其药剂为颗粒剂，可随身携带，服用方便，易于推广。
临床典型病例：
病例1、张某，女，24岁。患神经衰弱数载，夜难人寐，寐则多梦易醒，甚至彻夜不眠。曾经中西药治疗，效果不佳。改用此配方服用一周后，患者当即安然人寐。依法巩固治疗半个月，旧症消失。随访3年，未见复发。
病例2、张某，女，35 岁，农民。患者于11年前，生产后3天即感心烦意乱，不能人睡，连续1月余每夜仅浅睡3～4小时，嗣后，经治虽睡时稍增，但多恶梦，且素感头昏沉，胸闷，纳谷不馨。有时也服安定或中药，症状好转一时，逾后复故，渐至稍有睡意，即被惊醒，惊绪易激动，畏闻响声，现已无从事家务及农事之能。脉涩，舌红，苔薄白腻，脑电图及血压检查均无异常，无思维、情感、行为及与环境相互之间不协调现象，但有其父失眠等神经症家族病史。诊为神经性失眠，辨证为心肾不交，胆虚痰扰。按此方治疗，共服药25剂，诸症皆除。半年后，已康复劳动，一切如常。
病例3、王某，男，高中生，高二开始出现入睡困难、睡眠浅的症状，且上课不能集中精神，经常走神，症状处于1个月以后，开始服用本药物，服用一周后症状消失，至今未复发，孩子睡眠好了，上课精神也集中了，目前成绩排名年级前十。
病例4、张洋，男，29岁，毕业后面临就业压力，常常半夜睡不着，精神处于高度紧张，持续失眠3周，开始服用本药物，服用3天后症状消失，又服用3天进行巩固后已痊愈。
病例5、林某，男，37岁，患者因工作压力大、应酬多经常熬夜到凌晨，造成入睡难、睡中易惊醒、多梦，严重时彻夜难眠，西医诊断为失眠（神经官能症），经常服用镇静***。，因长期服用***出现口干、大便干结的症状。3个月后开始服用本药物，一周后睡眠好了，15天后基本痊愈，后又加5天进行巩固，之后痊愈。
四、具体实施方式
下面结合具体实施例对本发明作进一步的解释和说明：
实施例1：一种治疗失眠的药物，由以重量份为单位，制成其有效成分的原料药为：竹茹30份，枳实20份，陈皮40份，法半夏30份，茯神35份，黄连25份，牡丹皮20份，栀子25份，珍珠母30份，炙甘草25份，柏子仁20份，决明子20份，阿胶20份，桑葚25份，夜交藤15份，大枣30份，莲子15份，何首乌20份，远志30份，郁金15份，龙眼15份，龙骨20份，合欢花30份，百合25份。
上面所述的治疗失眠的药物的剂型为颗粒剂。
所述的治疗失眠的药物的制备方法，其具体加工步骤如下：
A、称取所述重量份的各原料药混合在一起，加6倍量水浸泡30~40分钟，然后加热煎煮1.5小时，得煎煮液A和药渣A；
B、向药渣A中加入4倍量的水，加热煎煮1小时，得煎煮液B和药渣B；
C、向B中加入2倍量的水，加热煎煮40分钟，得煎煮液C和药渣C；
D、合并3次煎煮液，静止10小时后，过滤，得滤液A；
E、将滤液A蒸发浓缩致稠膏状，停止加热；
F、50-60°干燥后，粉碎至120目的药粉，分装、密封、包装，即得到治疗失眠症中药的颗粒剂。
实施例2： 一种治疗失眠的药物，由以重量份为单位，制成其有效成分的原料药为：竹茹45份，枳实30份，陈皮50份，法半夏45份，茯神50份，黄连35份，牡丹皮30份，栀子35份，珍珠母35份，炙甘草35份，柏子仁30份，决明子30份，阿胶25份，桑葚35份，夜交藤27份，大枣40份，莲子22份，何首乌30份，远志45份，郁金25份，龙眼22份，龙骨27份，合欢花37份，百合35份。
实施例3、一种治疗失眠的药物，由以重量份为单位，制成其有效成分的原料药为：竹茹60份，枳实40份，陈皮60份，法半夏60份，茯神65份，黄连45份，牡丹皮40份，栀子45份，珍珠母40份，炙甘草45份，柏子仁40份，决明子40份，阿胶30份，桑葚45份，夜交藤40份，大枣50份，莲子30份，何首乌40份，远志30份，郁金35份，龙眼30份，龙骨35份，合欢花45份，百合45份。
实施例4、一种治疗失眠的药物，由以重量份为单位，制成其有效成分的原料药为：竹茹36份，枳实24份，陈皮44份，法半夏36份，茯神41份，黄连29份，牡丹皮24份，栀子29份，珍珠母33份，炙甘草29份，柏子仁24份，决明子24份，阿胶23份，桑葚29份，夜交藤21份，大枣24份，莲子19份，何首乌24份，远志36份，郁金19份，龙眼18份，龙骨23份，合欢花33份，百合29份。
实施例5、一种治疗失眠的药物，由以重量份为单位，制成其有效成分的原料药为：竹茹50份，枳实32份，陈皮52份，法半夏50份，茯神55份，黄连37份，牡丹皮32份，栀子37份，珍珠母37份，炙甘草37份，柏子仁32份，决明子32份 ，阿胶27份，桑葚37份，夜交藤31份，大枣42份，莲子25份、何首乌32份，远志50份，郁金27份，龙眼25份，龙骨30份，合欢花40份，百合37份。

Claims (4)

1.一种治疗失眠的药物，其特征在于：由以重量份为单位，制成其有效成分的原料药为：竹茹30～60份，枳实20～40份，陈皮40～60份，法半夏30～60份，茯神35～65份，黄连25～45份，牡丹皮20～40份，栀子25～45份，珍珠母30～40份，炙甘草25～45份，柏子仁20～40份，决明子20～40份，阿胶20～30份，桑葚25～45份，夜交藤15～40份，大枣30～50份，莲子15～30份，何首乌20～40份，远志30～60份，郁金15～35份，龙眼15～30份，龙骨20～35份，合欢花30～45份，百合25～45份。
2. 根据权利要求1所述的治疗失眠的药物，其特征在于：由以重量份为单位，制成其有效成分的原料药为：竹茹45份，枳实30份，陈皮50份，法半夏45份，茯神50份，黄连35份，牡丹皮30份，栀子35份，珍珠母35份，炙甘草35份，柏子仁30份，决明子30份 ，阿胶25份，桑葚35份，夜交藤27份，大枣40份，莲子22份，何首乌30份，远志45份，郁金25份，龙眼22份，龙骨27份，合欢花37份，百合35份。
3.根据权利要求1或2所述的治疗失眠的药物，其特征在于：所述治疗失眠的中药的剂型为颗粒剂。
4.权利要求3所述的治疗失眠的药物的制备方法，其具体加工步骤如下：
A、称取所述重量份的各原料药混合在一起，加6倍量水浸泡30~40分钟，然后加热煎煮1.5小时，得煎煮液A和药渣A；
B、向药渣A中加入4倍量的水，加热煎煮1小时，得煎煮液B和药渣B；
C、向B中加入2倍量的水，加热煎煮40分钟，得煎煮液C和药渣C；
D、合并3次煎煮液，静止10小时后，过滤，得滤液A；
E、将滤液A蒸发浓缩致稠膏状，停止加热；
F、50-60°干燥后，粉碎至120目的药粉，分装、密封、包装，即得到治疗失眠症中药的颗粒剂。
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