CN108670203A - A kind of imaging device - Google Patents
A kind of imaging device Download PDFInfo
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- CN108670203A CN108670203A CN201810558755.1A CN201810558755A CN108670203A CN 108670203 A CN108670203 A CN 108670203A CN 201810558755 A CN201810558755 A CN 201810558755A CN 108670203 A CN108670203 A CN 108670203A
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- 238000003384 imaging method Methods 0.000 title claims abstract description 54
- 238000001506 fluorescence spectroscopy Methods 0.000 claims abstract description 26
- 230000002269 spontaneous effect Effects 0.000 claims abstract description 8
- 230000005284 excitation Effects 0.000 claims abstract description 7
- 230000002159 abnormal effect Effects 0.000 claims description 60
- 206010028980 Neoplasm Diseases 0.000 claims description 54
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- 240000009038 Viola odorata Species 0.000 description 5
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- 235000002254 Viola papilionacea Nutrition 0.000 description 5
- 241001062009 Indigofera Species 0.000 description 3
- 230000000747 cardiac effect Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000011514 reflex Effects 0.000 description 2
- 241001269238 Data Species 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000002073 fluorescence micrograph Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
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- 239000004973 liquid crystal related substance Substances 0.000 description 1
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- 230000000750 progressive effect Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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Abstract
This application discloses a kind of imaging devices, wherein the imaging device includes：Light source, harvester and processing unit；Wherein, light source, for emitting preset multichannel narrow band light；Multichannel narrow band light is used to form white light and narrow-band feature light, and as fluorescent exciting；Harvester obtains multipath reflection light data for acquiring multipath reflection light, and acquisition fluorescence obtains fluorescence data；Multipath reflection light is：The narrow band light of white light and narrow-band feature light is formed in multichannel narrow band light through the light of Tissue reflectance to be diagnosed；Fluorescence is：In multichannel narrow band light as the narrow band light of fluorescent exciting excitation described in after diagnosing tissue, the spontaneous fluorescence of tissue to be diagnosed；Processing unit forms White-light image and the feature light image of tissue to be diagnosed for foundation multipath reflection light data, and the fluorescent image of tissue to be diagnosed is formed according to multipath reflection light data and fluorescence data.Imaging device through the invention can generate White-light image, feature light image and fluorescent image.
Description
Technical field
This application involves imaging fields, more particularly to a kind of imaging device.
Background technology
Currently, in order to improve the diagnostic accuracy of tissue early-stage cancer to be diagnosed, need to correspond in conjunction with the tissue to be diagnosed
Different type image information, determine whether the tissue to be diagnosed occurs early carcinomatous change.Different types of image may include
White-light image, feature light image and fluorescent image.Wherein, White-light image offer group is woven in color and structure letter under white-light illuminating
Breath；Hemoglobin of the feature light image based on tissue resorption, provides blood vessel network contrast information；Fluorescent image provides tissue
Autofluorescence factor information.
Currently, imaging device can be only generated White-light image and feature light image, or it can be only generated White-light image and fluorescence
Image.Therefore, generally judge whether tissue to be diagnosed occurs the image type that early carcinomatous change is combined and be：White-light image and feature
Light image is combined or White-light image is combined with fluorescent image.
Since different types of image reflects the different biological nature information of tissue to be diagnosed, and the life of tissue to be diagnosed
Object characteristic information is more, judge tissue to be diagnosed whether occur early carcinomatous change accuracy it is higher.Therefore, it is necessary to one kind to give birth to
At the imaging device of White-light image, feature light image and fluorescent image.In turn, in conjunction with White-light image, feature light image and
Fluorescent image, raising judge whether tissue to be diagnosed occurs the accuracy of early carcinomatous change.
Invention content
Based on this, present applicant proposes a kind of imaging devices, to generate White-light image, feature light image and fluorogram
Picture.
Technical solution provided by the present application is：
This application discloses a kind of imaging devices, including：Light source, harvester and processing unit；Wherein,
The light source, for emitting preset multichannel narrow band light；The multichannel narrow band light is used to form white light and narrowband is special
Light is levied, and as fluorescent exciting；
The harvester obtains multipath reflection light data for acquiring multipath reflection light, and acquisition fluorescence obtain it is glimmering
Light data；The multipath reflection light is：White light is formed in the multichannel narrow band light and the narrow band light of narrow-band feature light is diagnosed through waiting
The light of Tissue reflectance；The fluorescence is：It waits diagnosing as described in the excitation of the narrow band light of fluorescent exciting in the multichannel narrow band light
After tissue, the spontaneous fluorescence of the tissue to be diagnosed；
The processing unit, for formed according to the multipath reflection light data White-light image of tissue diagnose with
Feature light image, and form according to the multipath reflection light data and the fluorescence data fluorogram of the tissue to be diagnosed
Picture.
Wherein, the harvester includes first sensor；
The light source is specifically used for the first narrow band light of time division emission and the second narrow band light；First narrow band light is：It is described
The narrow band light of white light and narrow-band feature light is used to form in multichannel narrow band light；Second narrow band light is：The multichannel narrow band light
The middle narrow band light as fluorescent exciting；
The first sensor, the multipath reflection for acquiring Tissue reflectance to be diagnosed described in the first narrow band light warp
Light generates multipath reflection light data, and the spontaneous fluorescence of tissue to be diagnosed described in acquisition the second narrow band light excitation, raw
At fluorescence data.
Wherein, the harvester includes object lens and second sensor, and the quantity of the object lens is destination number；The mesh
Mark quantity is emitted the way of narrow band light by the light source；Wherein, different object lens allow by preset wavelength range mutually not
Overlapping；Different object lens allow by light be radiated at the region non-overlapping copies of the second sensor；
The object lens, for by the multipath reflection light and the fluorescence, correspondence to focus on the mutual of the second sensor
Nonoverlapping region；
The second sensor obtains the multipath reflection light data, and acquisition for acquiring the multipath reflection light
The fluorescence obtains the fluorescence data.
Wherein, the harvester includes optical filter and 3rd sensor；
The optical filter, for allowing the reflected light by not going the same way or fluorescence in different preset time periods；Wherein, one
Preset time period only allows through reflected light all the way or fluorescence；
4th sensor obtains the multipath reflection light data, and acquisition for acquiring the multipath reflection light
The fluorescence obtains the fluorescence data.
Wherein, the processing unit, is additionally operable to：
By the preset model after the input training of the White-light image, the feature light image and the fluorescent image；It is described
Preset model after training for identification in image doubtful cancer Abnormal tissue areas, and determine that the Abnormal tissue areas is
The probability of cancer；
Obtain the first Abnormal tissue areas of doubtful cancer in the White-light image that preset model exports after the training
With the second abnormal structure that first Abnormal tissue areas is doubtful cancer in the first probability of cancer, the feature light image
Region and second Abnormal tissue areas are different for the third of doubtful cancer in the second probability of cancer and the fluorescent image
Normal tissue regions and the third probability that the third Abnormal tissue areas is cancer；
Based on first Abnormal tissue areas, second Abnormal tissue areas and the third Abnormal tissue areas,
4th Abnormal tissue areas of doubtful cancer in tissue to be diagnosed described in determination；
Based on first probability, second probability and the third probability, the 4th Abnormal tissue areas is determined
For the 4th probability of cancer.
Wherein, the processing unit, is additionally operable to：
After generating the White-light image, the feature light image and the fluorescent image, merge the White-light image,
Arbitrary two or three in the feature light image and the fluorescent image, obtain blending image.
Wherein, the processing unit is additionally operable to mark the 4th Abnormal tissue areas in the blending image.
Wherein, which further includes：Display device；
The display device, for showing the White-light image, the feature light image, the fluorescent image, described melting
It closes image and is marked with one or more in the blending image of the 4th Abnormal tissue areas.
Wherein, the display device, is additionally operable to：
In the case where showing that the label has the blending image of the 4th Abnormal tissue areas, diagnostic message is shown；
The diagnostic message indicates that the 4th Abnormal tissue areas is the probability of cancer.
Wherein, the light source, for emitting multichannel narrow band light, including：
The light source is specifically used for the red narrow band light of transmitting, green narrow band light, blue narrow band light and fluorescent exciting.
The application's has the beneficial effect that：
Since the light source of imaging device in the prior art is broad spectrum light source or narrowband lazy weight, feature can be only generated
Light and white light or white light and fluorescent exciting, cannot generate characteristic light, white light and fluorescent exciting simultaneously；It is thus impossible to
Generate White-light image, feature light image and fluorescent image.And the emitted multichannel narrowband luminous energy of light source in the embodiment of the present application
White light, narrow-band feature light are enough formed, and fluorescent exciting can be used as.It is used to form white light and narrowband in the multichannel narrow band light
The narrow band light of characteristic light is through Tissue reflectance multipath reflection light to be diagnosed, the narrow band light in the multichannel narrow band light as fluorescent exciting
Excite this after diagnosing tissue, the tissue autofluorescence to be diagnosed；Wherein, multichannel narrow band light can be as needed, determines per road
The wave-length coverage of narrow band light, and then identified multichannel narrow band light is enable to form white light and narrow-band feature light, and can make
For fluorescent exciting；Harvester in the embodiment of the present application can acquire the multipath reflection light and obtain multichannel transmitting light data,
And it acquires the fluorescence and obtains fluorescence data；Therefore, the imaging device in the embodiment of the present application can be based on obtained multichannel
Reflected light data generates White-light image and feature light image, and generates fluorescent image based on obtained fluorescence data.In turn,
Based on the information of the White-light image, feature light image and the fluorescent image that are generated, raising judges whether tissue to be diagnosed occurs
The accuracy of early carcinomatous change.
Description of the drawings
In order to illustrate the technical solutions in the embodiments of the present application or in the prior art more clearly, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
The embodiment of application for those of ordinary skill in the art without creative efforts, can also basis
The attached drawing of offer obtains other attached drawings.
Fig. 1 is a kind of structural schematic diagram of imaging device in the application；
Fig. 2 is the structural schematic diagram of another imaging device in the application；
Fig. 3 is the structural schematic diagram of another imaging device in the application；
Fig. 4 is the structural schematic diagram of another imaging device in the application；
Fig. 5 is the structural schematic diagram of another imaging device in the application.
Specific implementation mode
Below in conjunction with the attached drawing in the embodiment of the present application, technical solutions in the embodiments of the present application carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of embodiments of the present application, instead of all the embodiments.It is based on
Embodiment in the application, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall in the protection scope of this application.
With reference to figure 1, show that a kind of structural schematic diagram of imaging device, the imaging device may include light source in the application
101, first sensor 102, processing unit 103 and display device 104.
Wherein, light source 101 can be the red narrow band light of 620nm with emission center wavelength, centre wavelength for 532nm green
The blue violet light that the blue narrow band light and centre wavelength that narrow band light, centre wavelength are 450nm are 415nm.Wherein, centre wavelength is
The blue narrow band light that the green narrow band light and centre wavelength that red narrow band light, the centre wavelength of 620nm is 532nm are 450nm can
To form white light；The blue violet light that the blue narrow band light and centre wavelength that centre wavelength is 450nm are 415nm can form narrowband spy
Levy light；Light source 101 adds the fluorescent exciting that centre wavelength is 405nm again can be used as fluorescent exciting.
After light source 101 emits red narrow band light, green narrow band light, blue narrow band light, royal purple narrow band light and fluorescent exciting,
Red narrow band light, green narrow band light, blue narrow band light and royal purple narrow band light are respectively radiated to tissue to be diagnosed, the tissue to be diagnosed
Reflect red narrowband reflection light, green narrowband reflection light, blue narrowband reflection light and royal purple narrowband reflection light；Fluorescent exciting
It is irradiated to the tissue to be diagnosed, this sends out fluorescence certainly after diagnosis tissue after excitation.
In practical applications, light source 101 can be for red narrow band light, the wave-length coverage of 620nm with emission center wavelength
The green narrow band light and centre wavelength of 540~600nm is the blue narrow band light of 450nm.Wherein, centre wavelength is the red of 620nm
The blue narrow band light that the green narrow band light and centre wavelength that color narrow band light, wave-length coverage are 540~600nm are 450nm can be with shape
At white light；The blue narrow band light that the green narrow band light and centre wavelength that wave-length coverage is 540~600nm are 450nm can be formed
Narrow-band feature light；Wave-length coverage, which is the green narrow band light of 540~600nm, can be used as fluorescent exciting.
Wherein, red narrow band light, green narrow band light and the blue narrow band light that light source 101 is emitted are irradiated to and wait for diagnostic bank
It knits, Tissue reflectance red narrowband reflection light, green narrowband reflection light and the blue narrowband reflection light to be diagnosed；Meanwhile wavelength model
Tissue autofluorescence to be diagnosed can also be excited for the green narrow band light of 540~600nm by enclosing.
Above-mentioned two kinds of ways of realization for giving the multichannel narrow band light that light source 101 is emitted, certainly in practical applications, light
Source 101 can also emit other kinds of narrow band light.The purpose of light source 101 is transmitting multichannel narrow band light, also, is emitted more
As long as road narrow band light can form white light and narrow-band feature light, and can be used as fluorescent exciting.For 101 institute of light source
The particular contents such as color, wave-length coverage and the centre wavelength of multichannel narrow band light of transmitting, the present embodiment are not especially limited.
First sensor 102 obtains multipath reflection light data for acquiring the multipath reflection light that tissue to be diagnosed is reflected,
And it acquires the spontaneous fluorescence of tissue to be diagnosed and obtains fluorescence data.
The multipath reflection light that is reflected through tissue to be diagnosed in the multichannel narrow band light that light source 101 is emitted with through waiting for diagnostic bank
After knitting spontaneous fluorescence, when first sensor 102 acquires the multipath reflection light with fluorescence, since fluorescence may be by multipath reflection
Light covers, therefore, in the present embodiment, 101 the first narrow band light of time division emission of light source and the second narrow band light, wherein the first narrowband
Light is the narrow band light that white light and narrow-band feature light are used to form in multichannel narrow band light；Second narrow band light is conduct in multichannel narrow band light
The narrow band light of fluorescent exciting.
When 101 the first narrow band light of time division emission of light source and the second narrow band light, first sensor 102 can acquisition time
Multipath reflection light and fluorescence can collect multipath reflection light data and fluorescence data in turn, avoid fluorescence by multipath reflection light
It is covered.
For example, when the multichannel narrow band light that light source 101 is emitted is：Centre wavelength is the red narrow band light of 620nm, middle cardiac wave
Blue violet light that blue narrow band light, the centre wavelength that green narrow band light, the centre wavelength of a length of 532nm is 450nm are 415nm and in
The fluorescent exciting of a length of 405nm of cardiac wave.Wherein, red narrow band light, the centre wavelength that centre wavelength is 620nm are 532nm's
Green narrow band light, the blue narrow band light that centre wavelength is 450nm are for synthesizing white light；Centre wavelength is the blue narrowband of 450nm
Light and the blue violet light that centre wavelength is 415nm are used to form narrow-band feature light；Centre wavelength is that the fluorescent exciting of 405nm is used for
Excite tissue autofluorescence to be diagnosed；At this point, red narrow band light, centre wavelength that the first emission center wavelength of light source 101 is 620nm
Four tunnel of blue violet light that the blue narrow band light and centre wavelength that green narrow band light, centre wavelength for 532nm are 450nm are 415nm
Narrow band light, for the four tunnels narrow band light through four tunnel reflected light of Tissue reflectance to be diagnosed, first sensor 102 acquires four tunnel reflection at this time
Light obtains four road reflected light datas.
Later, 101 emission center wavelength of light source is the fluorescent exciting of 405nm, and the fluorescent exciting emitted at this time swashs
Tissue autofluorescence to be diagnosed is sent out, then, first sensor 102 acquires the fluorescence and obtains fluorescence data.
After first sensor collects multipath reflection light data and/or fluorescence data, then, 103 base of processing unit
White-light image and feature light image are generated in multipath reflection light data, fluorescent image is generated based on fluorescence data.Specifically, working as light
Source 101 emit multichannel narrow band light be：The green narrowband that red narrow band light, the centre wavelength that centre wavelength is 620nm are 532nm
The royal purple narrow band light and centre wavelength that blue narrow band light, the centre wavelength that light, centre wavelength are 450nm are 415nm are 405nm's
When fluorescence excitation light, processing unit 103 is by red reflex light data, G color reflected light data and blue reflected light data and in vain
The corresponding warp factor of light image carries out convolution, obtains White-light image；By G color reflected light data, blue reflected light data and indigo plant
Purple reflected light data warp factor corresponding with feature light image carries out convolution, obtains feature light image；By fluorescence data and indigo plant
Color reflected light data warp factor corresponding with fluorescent image carries out convolution, obtains fluorescent image.
Wherein, White-light image, feature light image and the corresponding warp factor of fluorescent image are matrix, each image
Light data species number needed for this kind of image of the line number of corresponding matrix and generation is identical, and columns is all 3.For example, white light figure
As three kinds of corresponding red reflex light data, G color reflected light data and blue reflected light data data, therefore, White-light image pair
The line number for the warp factor answered is 3；Feature light image corresponds to G color reflected light data, blue reflected light data and royal purple reflected light
Three kinds of data of data, therefore, the line number of the corresponding warp factor of feature light image is 3；Fluorescent image corresponds to fluorescence data and indigo plant
Both data of color reflected light data, therefore, the line number of the corresponding warp factor of fluorescent image is 2.In practical applications, fluorescence
The generation of image can also be obtained fluorescence data divided by blue narrowband light data other than by the way of convolution.
Display device 104, the White-light image generated for display processing unit 103, feature light image and fluorescent image
In it is one or more.
With reference to figure 2, the structural schematic diagram of another imaging device in the application is shown, which includes：Light source
201, object lens 202, object lens 203, object lens 204, object lens 205 and second sensor 206, processing unit 207 and display device 208.
Wherein, the multichannel narrow band light that light source 201 is specifically emitted and 101 phase of light source in the imaging device corresponding to Fig. 1
Together, particular content can be with the particular content of the light source 101 in reference chart 1, and which is not described herein again.
In this imaging device, there is specific plated film on object lens 202, object lens 203, object lens 204 and object lens 205, at this time not
Same object lens can pass through the narrow band light of different wavelength range respectively.For example, when the multichannel narrow band light that light source is emitted is respectively
Red narrow band light, green narrow band light, blue narrow band light and fluorescent exciting, at this point, object lens 202 may only pass through red narrowband
Light, object lens 203 may only may only may only be passed through by blue narrow band light, object lens 204 by blue narrow band light, object lens 204
Fluorescence.In this imaging device, object lens and the position relationship before second sensor 206 need to meet different object lens by
The region that light is radiated at second sensor is not overlapped.For example, object lens 202, object lens 203, object lens 204 and object lens 205 form a line,
Certain spacing is kept between two neighboring object lens so that the difference of second sensor 206 is radiated at by the light of different object lens
Region, and different zones non-overlapping copies.
It should be noted that in this imaging device, because work as there are four types of the narrow band lights that light source is emitted, therefore object lens
Number is 4, and in practical applications, the quantity holding of narrow band light that the number of object lens need to only be emitted with light source is identical,
Particular number is needed to be determined according to the particular content of light source.
The multipath reflection light and fluorescence for being emitted light source 201 in object lens 202, object lens 203, object lens 204 and object lens 205,
It is mapped in respectively in second sensor 206 behind the region of non-overlapping copies, then, second sensor 206 acquires at different zones
Reflected light obtains reflected light data, and acquisition fluorescence obtains fluorescence data.
After second sensor 204 obtains multipath reflection light data and fluorescence data, then, processing unit 207 is based on more
Road reflected light data generates White-light image and feature light image, and generates fluorescent image based on fluorescence data.Processing is filled
The specific implementation for setting 207 generation White-light images, feature light image and fluorescent image can be with processing unit 103 in reference chart 1
The process of White-light image, feature light image and fluorescent image is generated, which is not described herein again.
Display device 208, the White-light image generated for display processing unit 207, feature light image and fluorescent image
In it is one or more.
With reference to figure 3, the structural schematic diagram of another imaging device in the application is shown, which may include light
Source 301, optical filter 302,3rd sensor 303, processing unit 304 and display device 305.
Wherein, the multichannel narrow band light that light source 201 is specifically emitted and 101 phase of light source in the imaging device corresponding to Fig. 1
Together, particular content can be with the particular content of the light source 101 in reference chart 1, and which is not described herein again.
In this imaging device, optical filter 302 at different times passes through the narrow band light of different wavelength range to be radiated at
In 3rd sensor 303, it is therefore an objective to which 3rd sensor 303 is acquired the every road reflected light and wait for that tissue to be diagnosed is reflected respectively
Diagnose the spontaneous fluorescence of tissue.Specifically, the optical filter 302 can be liquid crystal tunable optical filter, which exists
One preset time period only allows a kind of reflected light of color or fluorescence to pass through.Therefore, in continuous multiple preset time periods
Interior, 3rd sensor 303 can collect different reflected lights and obtain multipath reflection light data respectively, and acquisition fluorescence obtains
Fluorescence data.
Multipath reflection light data is obtained in optical filter 302, after 3rd sensor 303 obtains fluorescence data, then, processing dress
It sets 304 and White-light image and feature light image is generated based on multipath reflection light data, and fluorescent image is generated based on fluorescence data.
The specific implementation that White-light image, feature light image and fluorescent image are generated for processing unit 304 can be in reference chart 1
The process that device 103 generates White-light image, feature light image and fluorescent image is managed, which is not described herein again.
Display device 305, the White-light image generated for display processing unit 304, feature light image and fluorescent image
In it is one or more.
With reference to figure 4, the structural schematic diagram of another imaging device in the application is shown, which includes light source
401, harvester 402, processing unit 403 and display device 404.
Wherein, light source 401 is identical as the function of the light source 101 in the imaging device of Fig. 1 and specific implementation, specific interior
Appearance can be with the light source 101 in the imaging device of reference chart 1, and which is not described herein again.
Harvester 402 and the function of the harvester 102 in the imaging device of Fig. 1 are identical as specific implementation, tool
Holding in vivo can be with the harvester 102 in the imaging device of reference chart 1, and which is not described herein again.
For processing unit 403, for generating White-light image and feature light image, Yi Jiji based on multipath reflection light data
Fluorescent image is generated in multipath reflection light data and fluorescence data.White-light image, feature light image are generated for processing unit 403
White-light image, feature light image and fluorescence are generated with the processing unit 103 in the process of fluorescent image, with the imaging device of Fig. 1
The process of image is identical, and particular content can be with the processing unit 103 in the imaging device of reference chart 1, and which is not described herein again.
Processing unit 403 is other than generating White-light image, feature light image and fluorescent image in this imaging device, also
For merging arbitrary two or three of image in White-light image, feature light image and fluorescent image, blending image is obtained.
Specifically, when being merged to arbitrary two or three in White-light image, feature light image and fluorescent image, in order to merge
Image information afterwards can more directly reflect for determining whether tissue to be diagnosed occurs the space profiles structure of early carcinomatous change
White-light image, feature light image and fluorescent image are filtered by information, processing unit 403 by FIR filter respectively,
Obtain filtered White-light image, filtered feature light image and filtered fluorescent image.Then, processing unit 403 will
Melted for arbitrary two or three in filtered White-light image, filtered feature light image and filtered fluorescent image
It closes.
In this imaging device, in order to preferably assist doctor to judge whether tissue to be diagnosed occurs early carcinomatous change, to pre-
If model is trained so that the preset model after training is with doubtful in identification White-light image, feature light image and fluorescent image
The Abnormal tissue areas and Abnormal tissue areas of cancer are the probability of cancer.Wherein, the training process of preset model can be with
For：It is cancer by the White-light image of the Abnormal tissue areas of the doubtful early-stage cancer largely marked in advance and Abnormal tissue areas
The sample of the probability of disease, input preset model are trained the preset model so that the preset model after training has identification
The Abnormal tissue areas of doubtful cancer in White-light image, and probability that the Abnormal tissue areas identified is cancer.For spy
Levy light image and fluorescent image, method that preset model is trained with preset model is trained by White-light image
Method is identical, and which is not described herein again.
It should be noted that this imaging device only gives a kind of method of trained preset model, in practical applications also
Other modes may be used to be trained preset model, the present embodiment is not construed as limiting specific training method, as long as instruction
Preset model after white silk can identify the Abnormal tissue areas of doubtful cancer in White-light image, and determine the Abnormal tissue areas
For the probability of cancer；Can be with the Abnormal tissue areas and the Abnormal tissue areas of doubtful cancer in identification feature light image
The probability of cancer；And it can identify that the Abnormal tissue areas of doubtful cancer and the Abnormal tissue areas are in fluorescent image
The probability of cancer.
After the preset model after being trained, then, the white light figure that this imaging device is generated processing unit 403
Picture, feature light image and fluorescent image input in the preset model after the training, and the preset model determination after the training is inputted
Each image in doubtful early-stage cancer Abnormal tissue areas and the Abnormal tissue areas be cancer probability；And it exports
The Abnormal tissue areas and Abnormal tissue areas of doubtful early-stage cancer are the diagnostic message of the probability of cancer in each image.
Processing unit 403 can be with the exception of doubtful cancer in each image that the preset model after combined training is exported
Tissue regions and the probability that Abnormal tissue areas is cancer, determine the Abnormal tissue areas of doubtful cancer in tissue to be diagnosed,
And this waits for that diagnosis is organized as the probability of cancer.In addition, processing unit 403 can also will be doubtful in identified tissue to be diagnosed
The tissue regions of cancer mark in blending image.
Display device 404, the White-light image generated for display processing unit 403, feature light image, fluorescent image,
It is one or more in blending image, the blending image for the Abnormal tissue areas for being marked with doubtful cancer.
In this imaging device, processing unit 403 can synthesize blending image, also, processing unit 403 can pass through instruction
Preset model after white silk determines in White-light image, feature light image and fluorescent image, the Abnormal tissue areas of doubtful cancer, with
And the probability that Abnormal tissue areas is cancer.And the probability that the corresponding abnormal structure of each image of compositive index is cancer, it determines
Abnormal tissue areas is the probability of cancer in tissue to be diagnosed.Due to information of the processing unit 403 based on three kinds of images, to integrate
Abnormal tissue areas is the probability of cancer in determining tissue to be diagnosed, and the probability accuracy determined is improved.
With reference to figure 5, show that another imaging device in the application, the imaging device include light source 501, harvester
502, processing unit 503 and display device 504.
Wherein, the specific implementation of light source 501, harvester 502, processing unit 503 is filled with light source in Fig. 4 401, acquisition
The specific implementation for setting 402, processing unit 403 corresponds to identical, and which is not described herein again.
Include display device 504 in this imaging device, what which can be generated with display processing unit 503
White-light image, feature light image, fluorescent image and blending image, be marked with doubtful cancer Abnormal tissue areas blending image
In any one or more.Wherein, which can indicate follow-up with what display processing unit 503 was determined
There are the diagnostic messages of the probability of cancer for disconnected tissue.
In this imaging device, display device can show the blending image for being marked with Abnormal tissue areas, and display
Abnormal tissue areas is the diagnostic message of the probability of cancer, is that doctor judges that Abnormal tissue areas is cancer in the tissue to be diagnosed
Probability provide a higher foundation of accuracy.
Each embodiment is described by the way of progressive in this specification, the highlights of each of the examples are with it is other
The difference of embodiment, just to refer each other for identical similar portion between each embodiment.Herein, such as " first " and
The relational terms of " second " or the like are only used to distinguish one entity or operation from another entity or operation, and
Without necessarily requiring or implying that between these entities or operation, there are any actual relationship or orders.In the text
The word explanations such as "include", "comprise" be comprising meaning rather than exclusive or exhaustive meaning；That is, be " include but
Be not limited to " meaning.Deformation, same replacement without departing from the inventive concept of the premise, can also be made, improved etc., these
Belong to protection scope of the present invention.
The foregoing description of the disclosed embodiments, make professional and technical personnel in the field for realizing or use the application.
Various modifications to these embodiments will be apparent to those skilled in the art, as defined herein
General Principle can in other embodiments be realized in the case where not departing from spirit herein or range.Therefore, the application
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest range caused.
Claims (10)
1. a kind of imaging device, which is characterized in that including：Light source, harvester and processing unit；Wherein,
The light source, for emitting preset multichannel narrow band light；The multichannel narrow band light is used to form white light and narrow-band feature light,
And as fluorescent exciting；
The harvester obtains multipath reflection light data for acquiring multipath reflection light, and acquisition fluorescence obtains fluorescence number
According to；The multipath reflection light is：The narrow band light of white light and narrow-band feature light is formed in the multichannel narrow band light through tissue to be diagnosed
The light of reflection；The fluorescence is：As tissue to be diagnosed described in the excitation of the narrow band light of fluorescent exciting in the multichannel narrow band light
Afterwards, the spontaneous fluorescence of the tissue to be diagnosed；
The processing unit, White-light image and feature for forming the tissue to be diagnosed according to the multipath reflection light data
Light image, and form according to the multipath reflection light data and the fluorescence data fluorescent image of the tissue to be diagnosed.
2. imaging device according to claim 1, which is characterized in that the harvester includes first sensor；
The light source is specifically used for the first narrow band light of time division emission and the second narrow band light；First narrow band light is：The multichannel
The narrow band light of white light and narrow-band feature light is used to form in narrow band light；Second narrow band light is：Make in the multichannel narrow band light
For the narrow band light of fluorescent exciting；
The first sensor, the multipath reflection light for acquiring Tissue reflectance to be diagnosed described in the first narrow band light warp are raw
At multipath reflection light data, and the spontaneous fluorescence of tissue to be diagnosed described in acquisition the second narrow band light excitation, generate glimmering
Light data.
3. imaging device according to claim 1, which is characterized in that the harvester includes object lens and the second sensing
The quantity of device, the object lens is destination number；The destination number is emitted the way of narrow band light by the light source；Wherein, no
With object lens allow by preset wavelength range non-overlapping copies；Different object lens allow by light be radiated at it is described second pass
The region non-overlapping copies of sensor；
The object lens, for by the multipath reflection light and the fluorescence, corresponding to and focusing on not weighing mutually for the second sensor
Folded region；
The second sensor obtains the multipath reflection light data for acquiring the multipath reflection light, and described in acquisition
Fluorescence obtains the fluorescence data.
4. imaging device according to claim 1, which is characterized in that the harvester includes optical filter and third sensing
Device；
The optical filter, for allowing the reflected light by not going the same way or fluorescence in different preset time periods；Wherein, it presets for one
Period only allows through reflected light all the way or fluorescence；
4th sensor obtains the multipath reflection light data for acquiring the multipath reflection light, and described in acquisition
Fluorescence obtains the fluorescence data.
5. imaging device according to claim 1, which is characterized in that the processing unit is additionally operable to：
By the preset model after the input training of the White-light image, the feature light image and the fluorescent image；The training
Preset model afterwards for identification in image doubtful cancer Abnormal tissue areas, and determine that the Abnormal tissue areas is cancer
Probability；
Obtain the first Abnormal tissue areas of doubtful cancer and institute in the White-light image that preset model exports after the training
State the second Abnormal tissue areas that the first Abnormal tissue areas is doubtful cancer in the first probability of cancer, the feature light image
It is the third exception group of doubtful cancer in the second probability of cancer and the fluorescent image with second Abnormal tissue areas
Tissue region and the third probability that the third Abnormal tissue areas is cancer；
Based on first Abnormal tissue areas, second Abnormal tissue areas and the third Abnormal tissue areas, determine
4th Abnormal tissue areas of doubtful cancer in the tissue to be diagnosed；
Based on first probability, second probability and the third probability, determine that the 4th Abnormal tissue areas is cancer
4th probability of disease.
6. imaging device according to claim 5, which is characterized in that the processing unit is additionally operable to：
After generating the White-light image, the feature light image and the fluorescent image, the White-light image, described is merged
Arbitrary two or three in feature light image and the fluorescent image, obtain blending image.
7. imaging device according to claim 6, which is characterized in that
The processing unit is additionally operable to mark the 4th Abnormal tissue areas in the blending image.
8. imaging device according to claim 7, which is characterized in that further include：Display device；
The display device, for showing the White-light image, the feature light image, the fluorescent image, the fusion figure
Picture and be marked with it is one or more in the blending image of the 4th Abnormal tissue areas.
9. imaging device according to claim 8, which is characterized in that the display device is additionally operable to：
In the case where showing that the label has the blending image of the 4th Abnormal tissue areas, diagnostic message is shown；It is described
Diagnostic message indicates that the 4th Abnormal tissue areas is the probability of cancer.
10. according to imaging device as described in any one of claim 1 to 9, which is characterized in that the light source is more for emitting
Road narrow band light, including：
The light source is specifically used for the red narrow band light of transmitting, green narrow band light, blue narrow band light and fluorescent exciting.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
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| CN201810558755.1A CN108670203A (en) | 2018-06-01 | 2018-06-01 | A kind of imaging device |
| PCT/CN2018/122235 WO2019227907A1 (en) | 2018-06-01 | 2018-12-20 | Imaging device |
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|---|---|---|---|
| CN201810558755.1A CN108670203A (en) | 2018-06-01 | 2018-06-01 | A kind of imaging device |
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