CN108651861A - A kind of anti-oxidant curcumin Bean curd with duck blood and preparation method thereof - Google Patents
A kind of anti-oxidant curcumin Bean curd with duck blood and preparation method thereof Download PDFInfo
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- CN108651861A CN108651861A CN201810476245.XA CN201810476245A CN108651861A CN 108651861 A CN108651861 A CN 108651861A CN 201810476245 A CN201810476245 A CN 201810476245A CN 108651861 A CN108651861 A CN 108651861A
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- curcumin
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- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 title claims abstract description 247
- 229940109262 curcumin Drugs 0.000 title claims abstract description 151
- 239000004148 curcumin Substances 0.000 title claims abstract description 151
- 210000004369 blood Anatomy 0.000 title claims abstract description 125
- 239000008280 blood Substances 0.000 title claims abstract description 123
- 235000012754 curcumin Nutrition 0.000 title claims abstract description 123
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 title claims abstract description 122
- 241000272525 Anas platyrhynchos Species 0.000 title claims abstract description 82
- 235000013527 bean curd Nutrition 0.000 title claims abstract description 53
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 51
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 51
- 235000006708 antioxidants Nutrition 0.000 title claims abstract description 51
- 238000002360 preparation method Methods 0.000 title claims abstract description 44
- 210000002381 plasma Anatomy 0.000 claims abstract description 35
- 229920000642 polymer Polymers 0.000 claims abstract description 28
- 108010017384 Blood Proteins Proteins 0.000 claims abstract description 26
- 102000004506 Blood Proteins Human genes 0.000 claims abstract description 26
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 24
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 108090000190 Thrombin Proteins 0.000 claims abstract description 6
- 230000004913 activation Effects 0.000 claims abstract description 6
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- 238000007493 shaping process Methods 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 42
- 238000003756 stirring Methods 0.000 claims description 11
- 239000012460 protein solution Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000001509 sodium citrate Substances 0.000 claims description 8
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 6
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- 102000004169 proteins and genes Human genes 0.000 abstract description 16
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- 229910001628 calcium chloride Inorganic materials 0.000 abstract description 8
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- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
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- 244000163122 Curcuma domestica Species 0.000 description 8
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- KKAJSJJFBSOMGS-UHFFFAOYSA-N 3,6-diamino-10-methylacridinium chloride Chemical compound [Cl-].C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 KKAJSJJFBSOMGS-UHFFFAOYSA-N 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
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- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 108010088751 Albumins Proteins 0.000 description 4
- 102000009027 Albumins Human genes 0.000 description 4
- 108090001008 Avidin Proteins 0.000 description 4
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- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000006287 biotinylation Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L13/00—Meat products; Meat meal; Preparation or treatment thereof
- A23L13/20—Meat products; Meat meal; Preparation or treatment thereof from offal, e.g. rinds, skins, marrow, tripes, feet, ears or snouts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L13/00—Meat products; Meat meal; Preparation or treatment thereof
- A23L13/50—Poultry products, e.g. poultry sausages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/015—Inorganic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Botany (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract
The present invention discloses a kind of anti-oxidant curcumin Bean curd with duck blood and preparation method thereof, including following raw material：Duck blood, curcumin；Preparation method includes preparing anticoagulated whole blood, blood plasma separation, blood plasma separation, thrombin activation, heat-shaping etc..The present invention generates plasma protein curcumin embedding polymer using hydrophobic construction from part and acts directly in new blood, the insoluble matter for overcoming natural curcumin improves the stability of active constituent and the shelf-life, enhances intestinal absorption and cell and absorb, extend blood residence time, enhance anticancer effect etc.；Crosslinked action between using calcium chloride to make blood protein as activator in preparation process is reinforced, and the protective film formed positioned at protein outer layer makes the antioxygenic property of the curcumin embedded by albumen retain completely.
Description
Technical field
The invention belongs to food processing technology field more particularly to a kind of anti-oxidant curcumin Bean curd with duck blood and its preparation sides
Method.
Background technology
Duck blood taste cold in nature is salty, enrich blood with it is clearing heat and detoxicating, duck blood contains 16% in addition to the moisture containing 85% or so
The protein of left and right additionally contains various bioactivators rich in mineral elements and multivitamins such as iron, zinc, potassium, has
There is very high nutritive value；The diseases such as dysentery, over-strained hemoptysis can be treated with duck blood.For all boraxs, arsenic, vegetable poisoning etc., use
Duck blood, which gavages, all to be had a better effect；Duck blood can also treat punching on warm blood, apoplexy dizziness and prevention tumor in digestive tract；Duck blood is also rich
Containing ferroheme, it has very high medical value, has on the field that medicine and health products are studied and is widely applied very much.
Curcumin is a kind of phenolic complex extracted from turmeric, has stronger physiology and pharmacological activity, solution
Middle curcumin exists in the form of ketone-alkene tautomer, and wherein enol-type structure is more stablized, and is main existing for curcumin
Form.Researches show that the enol-type structures of curcumin and phenolic hydroxyl group to play an important role in inoxidizability for many.Numerous studies
Show that curcumin has anti-inflammatory, anti-oxidant, reducing blood lipid, inhibits type II diabetes complication, inhibit thrombus and myocardial infarction, resist
The bioactivity such as cancer, therefore curcumin has greatly development and application potentiality in food, pharmaceuticals industry.
Chinese CN105816885A patents provide a kind of drug albumin nano granular, preparation method and its in cancer targets
Application in treatment.The nanoparticle is the nano-particle that two kinds of albumen of Avidin and albumin contain insoluble anti-tumor medicament.
There are electrostatic interactions between Avidin and albumin, and the Avidin in nanoparticle can be combined with biotin.It is affine
Element can will contain the nanoparticle of drug targeted to biotin enrichment positions.Before giving the nanoparticle, biotinylation is used
The advance target tumor position of antibody, can improve distribution of the nano particle preparations in tumor locus.By biotinylated antibody and it is somebody's turn to do
It is more preferable that nano particle preparations drug combination can play the albumin nano granular drug combination than monoclonal antibody and without Avidin
Antitumous effect；The invention dissolves curcumin in preparation process using organic solvent, can cause in final products containing few
The organic solvent of amount, influences using effect.
Chinese CN107114799A patents disclose the ultrasonic preparation method of rapeseed protein microcapsules and as functions
The application of food is related to functional food microcapsules technology field.It is prepared by the raw material of following parts by weight：Rapeseed activity egg
In vain：10-25 parts；Curcumin：1-5 parts.It is super that the present invention is applied with adverse current during rapeseed activated protein embeds curcumin
Sound wave and frequency sweep ultrasonic wave change the higher structure of rapeseed activated protein, its structure is made to open, exposure active group, albumen
Matter forms small aggregation, is embedding bioactive ingredients to promote each aggregation to form microcapsules by hydrophobic interaction
Basis is provided.The preparation method of the rapeseed activated protein microcapsules of curcumin is embedded in the invention, technological operation is simple, prepares
It is not directed to organic reagent in the process, suitable for industrialized production, and rapeseed activated protein cost of material is cheap, preparation process letter
It is single；The invention is poor as health products user's use feeling using the activated protein containing curcumin, and is unfavorable for daily health-care effect.
Currently, in the structure research of curcumin and protein complex, it is mostly focused on vegetable protein, and for poultry
The research few people report for producing source protein, the recombination process generally used is complex, and cost is higher；Since curcumin is insoluble
Yu Shui is generally dissolved using organic solvent in preparation process so that is carried organic solvent in the product of preparation, is influenced to make
Use effect；The health medicine containing curcumin is generally prepared into using vegetable protein in the food containing curcumin at present, price is high
It is expensive, and as drug administration so that the experience sense of user is poor.Therefore, it is badly in need of designing a kind of anti-oxidant curcumin Bean curd with duck blood
And preparation method thereof to solve the above problems.
Invention content
In response to the problems existing in the prior art, the purpose of the present invention is to provide a kind of anti-oxidant curcumin Bean curd with duck blood and its
Preparation method, generating plasma protein-using hydrophobic construction from part, curcumin polymer acts directly on that work is improved in new blood
Property ingredient stability and the shelf-life, enhance intestinal absorption and cell and absorb, extend blood residence time, enhance anticancer effect
Fruit etc.；In preparation process retain using calcium chloride as activator the antioxygenic property of the curcumin complete.
To achieve the above object, the technical solution adopted by the present invention is：
The present invention provides a kind of anti-oxidant curcumin Bean curd with duck blood, includes the raw material of following parts by weight：
80-100 parts of duck blood；
0.2-0.6 parts of curcumin.
Curcumin has excellent treatment, health-care effect, but is significantly limited since the water of curcumin does not dissolve property
Its application in food is generally used using the preferable substance auxiliary of biological degradability；Currently, for curcumin and protein
In the structure research of compound, it is mostly focused on vegetable protein, and the research few people of livestock products source protein are reported, this hair
It is bright that curcumin-livestock products source protein compound is built using the plasma protein in livestock products source as carrier, it is added in food
It can effectively ensure that the stability and shelf-life of curcumin active constituent, enhancing intestinal absorption and cell absorb, extend curcumin
Residence time, enhancing anticancer effect in blood etc.；Livestock products source protein is compound is added with proper ratio by curcumin-by the present invention
In blood bean curd, for the exploitation of new type gel based food and new type functional food dispensing, certain application is provided and is used for reference, while can be with
User is set to be improved body in daily diet, it is contemplated that the acrid odors of curcumin, curcumin part of the invention
Number is 0.2-0.6 parts, and user is made more to be easily accepted by.
Preferably, the anti-oxidant curcumin Bean curd with duck blood, includes the raw material of following parts by weight：
100 parts of duck blood；
0.47 part of curcumin.
The present invention also provides a kind of preparation methods of anti-oxidant curcumin Bean curd with duck blood, include the following steps：
A, anticoagulated whole blood is prepared：Duck blood is collected when duck is butchered immediately, sodium citrate solution is added into duck blood in 5min,
It is filtered after stirring evenly, collects filtrate and obtain anticoagulated whole blood；
B, blood plasma detaches：It takes the anticoagulated whole blood to centrifuge, collects upper plasma, dilution, stirring 1-2h obtain plasma protein
Solution, lower layer's haemocyte recycling are for use；
C, hydrophobic assembling：The pH value of plasma protein solution described in regulating step b is incubated 20-60min to 10-12, and ginger is added
Flavine particle is protected from light stirring 20-60min, adjusts pH to neutrality, obtains plasma protein-curcumin polymer solution；
D, thrombin activation：It is thin that the blood described in step b is added in plasma protein described in step c-curcumin polymer solution
In born of the same parents, it is uniformly mixing to obtain the whole blood containing plasma protein-curcumin polymer；It is molten that calcium chloride is added into above-mentioned solution again
Liquid；The volume ratio of the whole blood and calcium chloride solution containing plasma protein-curcumin polymer is 7-10:1-3；
E, heat-shaping：Step d acquired solutions are put into thermostat water bath and are heated to solidifying to get anti-oxidant ginger completely
Flavine Bean curd with duck blood.
The preparation method of anti-oxidant curcumin Bean curd with duck blood of the present invention includes that preparation prepares anticoagulated whole blood, blood plasma point
From, hydrophobic assembling, thrombin activation, thermoforming process；The hydrophobic assembling is by adjusting pH value of solution, utilizing hydrophobic effect
Power forms the natural polymer of the water phase high-dissolvability of plasma protein-curcumin, to solve the water of the curcumin not
The problem that dissolubility causes medicinal effects poor；The thrombin activation be added the calcium chloride solution of suitable concentration and ratio in
In the blood containing curcumin so that crosslinked action between blood protein is reinforced, formed the protective film positioned at protein outer layer make by
The antioxygenic property of the curcumin of albumen embedding retains complete.
Preferably, a concentration of 0.9%-1.0% of sodium citrate solution described in step a；With the double-deck yarn after stirring evenly
Cloth filters.
Sodium citrate is non-toxic, has pH regulation performances and good stability, is often used as food additives, the present invention
The stability of fresh duck blood can be ensured by being acted in fresh duck blood using sodium citrate, prevent fresh duck blood quick solidification.
Preferably, in step c, the addition of the curcumin is 0.2-0.6g/100mL on the basis of anticoagulated whole blood, with
It is 0.3-1.0g/100mL on the basis of plasma protein.
The present invention embeds the curcumin using plasma protein as carrier, and inventor is obtained by many experiments, works as institute
It is 0.2-0.6g/100mL that curcumin addition, which is stated, on the basis of anticoagulated whole blood, is 0.3-1.0g/ on the basis of plasma protein
When 100mL, the embedding rate of the plasma protein-curcumin can reach 50% or more, improve the bioavailability of the curcumin.
Preferably, in step c, the pH value tune 12 of plasma protein solution described in regulating step b.The present invention adjusts pH most
12, it is capable of the degree of exposure of preferable regulatory protein hydrophobic structure, to promote plasma protein-curcumin to embed the structure of polymer
It builds.
Preferably, in step d, the concentration of the calcium chloride solution is 25-30mg/mL on the basis of anticoagulated whole blood；It is described
The volume ratio of whole blood and calcium chloride solution containing plasma protein-curcumin polymer is 8：1.
Preferably, in step e, the actual conditions of the heating are：15-20min is heated at 70-80 DEG C.The present invention's
Inventor obtains calcium chloride solution concentration in 25-30mg/mL by many experiments, described to contain plasma protein-curcumin polymer
Whole blood and calcium chloride solution volume ratio be 8：The anti-oxidant turmeric Vegetarian Duck that 15-20min is obtained is heated at 1,70-80 DEG C
It is 43.67% that the inoxidizability of curcumin described in blood bean curd, which retains the DPPH clearance rate average values before and after completely heating, and at
The elasticity for savoring Bean curd with duck blood is best.
Compared with prior art, the beneficial effects of the invention are as follows：
(1) curcumin is added in food as carrier using plasma protein by the present invention, overcomes natural ginger
The insoluble energy of flavine enhances the stability and shelf-life of curcumin active constituent, enhancing intestinal absorption and cell absorb, prolong
Long blood residence time enhances anticancer effect etc..
(2) present invention adjusts the degree of exposure of plasma protein hydrophobic structure by controlling pH value of solution, utilizes hydrophobic forces
Formed plasma protein-curcumin water phase height dissolving natural polymer, embedding rate is higher, the present invention in preparation process not
Organic solvent is introduced, health care, therapeutic effect are preferable；
(3) activator calcium chloride is added in the present invention in preparation process, so that the inoxidizability of the curcumin is retained complete,
Improve bioavailability；
(4) preparation process of the present invention is simple, cost is relatively low, and curcumin is acted in the life of people's diet, can
The treatment and health effect of curcumin is set to be dissolved in daily life.
Description of the drawings
Fig. 1 is a kind of Technology Roadmap of anti-oxidant curcumin Bean curd with duck blood of the present invention and preparation method thereof.
Specific implementation mode
Technical scheme of the present invention is clearly and completely described below, it is clear that described embodiment is only this
Invention a part of the embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art exist
The all other embodiment obtained under the conditions of creative work is not made, shall fall within the protection scope of the present invention.
The present invention provides a kind of anti-oxidant curcumin Bean curd with duck blood, includes the raw material of following parts by weight：
80-100 parts of duck blood；
0.2-0.6 parts of curcumin.
The curcumin is added in new blood using plasma protein as carrier and makes food by the present invention, makes the turmeric
The treatment of element, health-care effect are dissolved in daily life, the anti-oxidant curcumin duck blood obtained according to above-mentioned parts by weight
Bean curd, the stability of the active constituent of curcumin is preferably and the shelf-life is longer, intestinal absorption and cell good absorption effect, extends institute
It states curcumin residence time in blood, enhance anticancer effect, and Bean curd with duck blood is good in taste.Following embodiment exists
In above range.
Embodiment 1
The present embodiment provides a kind of anti-oxidant curcumin Bean curd with duck blood, include the raw material of following parts by weight：
100 parts of duck blood；
0.47 part of curcumin.
The preparation method of the anti-oxidant curcumin Bean curd with duck blood, includes the following steps：
A, anticoagulated whole blood is prepared：Fresh duck blood is collected when duck is butchered immediately, is added into the fresh duck bloods of 100mL in 5min
A concentration of 0.9%-1.0% sodium citrate solutions, stir evenly, and anticoagulated whole blood is obtained by filtration with double gauze；
The density of the anticoagulated whole blood is 1.06g/mL
B, blood plasma detaches：The anticoagulated whole blood is taken, is centrifuged at 0-4 DEG C using refrigerated centrifuge, upper plasma is collected,
Stirring and dissolving 1h obtains plasma protein solution under the action of magnetic stirring apparatus, and lower layer's haemocyte recycling is for use；
C, hydrophobic assembling：The pH to 12 of plasma protein solution described in 4mol/L NaOH solution regulating steps b is incubated
The turmeric crude granule of 0.5g/100mL is added in 30min, is protected from light stirring 30min, adjusts pH to 7 with 4mol/L HCl, obtains blood plasma
Albumen-curcumin polymer solution；
D, thrombin activation：It is thin that the blood described in step b is added in plasma protein described in step c-curcumin polymer solution
In born of the same parents, it is uniformly mixing to obtain the whole blood containing plasma protein-curcumin polymer；25mg/mL is added into above-mentioned solution again
Calcium chloride solution；The volume ratio of the whole blood and calcium chloride solution containing plasma protein-curcumin polymer is 8:1；
E, heat-shaping：Step d acquired solutions are put into 75 DEG C of thermostat water baths and heat 20min to complete solidification, i.e.,
Obtain anti-oxidant curcumin Bean curd with duck blood.
The assay method of curcumin embedding rate and load factor：
It takes plasma protein described in step c-curcumin polymer solution 2250g × 15min in super filter tube to centrifuge, goes to filter
Liquid 500uL is settled to 25mL, and it is the light absorption value at 450nm to survey it in wavelength, and calculates curcumin quality of dissociating, and is counted according to the following formula
Calculate the embedding rate and load factor of curcumin：
The embedding rate (%) of the curcumin=curcumin gross mass of (the free curcumin quality of curcumin gross mass -) × 100/；
Curcumin load factor (the %)=anti-oxidant curcumin duck blood in (the free curcumin quality of curcumin gross mass -) × 100/
Bean curd sample gross mass.
Test method of the plasma protein-curcumin polymer solution to the external clearance test of DPPH free radicals：
By plasma protein described in step c-curcumin polymer solution in 10mL centrifuge tubes, 2mL absolute ethyl alcohols are added,
Shake 10min under oscillator, after so that the plasma protein-curcumin polymer and ethyl alcohol is sufficiently mixed, 2250g ×
15min is centrifuged, and supernatant is curcumin release liquid.The DPPH of 20 μ L curcumins release liquids and 180uL 60umol/L are worked
Liquid mixing is used as prepare liquid, is detected with microplate reader at 530nm after concussion mixing, primary every 5min surveys, continuous to survey
40min。
Curcumin is replaced with 20 μ L absolute ethyl alcohols in blank control group；The above operation is carried out in the dark at room temperature.Reaction
Light absorption value of the mixed liquor at 530nm is the content for representing DPPH free radicals in system.In view of the light absorption value of curcumin itself,
20 μ L of curcumin release liquid and 180 μ L of absolute ethyl alcohol is added as the background absorption value of curcumin.
Clearance rate (%)=[A- (B-C)]/A × 100%.Wherein, A is the light absorption value of blank control group, and B is prepare liquid
Light absorption value, C are the background absorption value of curcumin prepare liquid.
The assay method of inoxidizability reserving degree：
Inoxidizability reserving degree (%)=(made from DPPH free radical scavenging activities-step e of solution made from step d
The DPPH free radical scavenging activities of product) solution made from × 100%/step d DPPH free radical scavenging activities；
Specific testing result is as described in Table 1, the anti-oxidant turmeric being prepared using preparation method of the present invention
Plain Bean curd with duck blood has higher embedding rate and load factor, is conducive to absorption of human body, and the curcumin inoxidizability retains journey
Degree is higher.
Embodiment 2
The present embodiment provides a kind of preparation methods of anti-oxidant curcumin Bean curd with duck blood, compared with Example 1, difference
It is, in step c, the pH to 10 of plasma protein solution described in 4mol/L NaOH solution regulating steps a.
Using test method described in embodiment 1 to the property of the anti-oxidant curcumin Bean curd with duck blood manufactured in the present embodiment
It can be tested, as shown in table 1.
Embodiment 3
The present embodiment provides a kind of anti-oxidant curcumin Bean curd with duck blood and preparation method thereof, compared with Example 1, difference
It is in including the raw material of following parts by weight：
100 parts of duck blood；
0.28 part of curcumin.
In step c, the addition of the turmeric crude granule is 0.3g/100mL.
Using test method described in embodiment 1 to the property of the anti-oxidant curcumin Bean curd with duck blood manufactured in the present embodiment
It can be tested, as shown in table 1.
Embodiment 4
The present embodiment provides a kind of anti-oxidant curcumin Bean curd with duck blood and preparation method thereof, compared with Example 1, difference
It is in including the raw material of following parts by weight：
100 parts of duck blood；
0.38 part of curcumin.
In step c, the addition of the turmeric crude granule is 0.4g/100mL.
Using test method described in embodiment 1 to the property of the anti-oxidant curcumin Bean curd with duck blood manufactured in the present embodiment
It can be tested, as shown in table 1.
Embodiment 5
The present embodiment provides a kind of anti-oxidant curcumin Bean curd with duck blood and preparation method thereof, compared with Example 1, difference
It is in including the raw material of following parts by weight：
100 parts of duck blood；
0.57 part of curcumin.
In step c, the addition of the turmeric crude granule is 0.6g/100mL.
Using test method described in embodiment 1 to the property of the anti-oxidant curcumin Bean curd with duck blood manufactured in the present embodiment
It can be tested, as shown in table 1.
Embodiment 6
The present embodiment provides a kind of preparation methods of anti-oxidant curcumin Bean curd with duck blood, compared with Example 1, difference
It is, in step d, the calcium chloride addition is 30mg/mL, the whole blood containing plasma protein-curcumin polymer
Volume ratio with calcium chloride solution is 4:1.
Using test method described in embodiment 1 to the property of the anti-oxidant curcumin Bean curd with duck blood manufactured in the present embodiment
It can be tested, as shown in table 1.
Embodiment 7
The present embodiment provides a kind of preparation methods of anti-oxidant curcumin Bean curd with duck blood, compared with Example 1, difference
It is, in step d, a concentration of 30mg/mL of the calcium chloride solution, the whole blood containing plasma protein-curcumin polymer
The volume ratio of solution and calcium chloride solution is 7:3.
Using test method described in embodiment 1 to the property of the anti-oxidant curcumin Bean curd with duck blood manufactured in the present embodiment
It can be tested, as shown in table 1.
Embodiment 8
The present embodiment provides a kind of preparation methods of anti-oxidant curcumin Bean curd with duck blood, compared with Example 1, difference
It is, in step e, step d acquired solutions is put into 75 DEG C of thermostat water baths and heat 25min to complete solidification.
Using test method described in embodiment 1 to the property of the anti-oxidant curcumin Bean curd with duck blood manufactured in the present embodiment
It can be tested, as shown in table 1.
Comparative example 1
This comparative example provides a kind of preparation method of anti-oxidant curcumin Bean curd with duck blood, includes the following steps,
A, fresh duck blood is collected when duck is butchered immediately, a concentration of 0.9%- is added into the fresh duck bloods of 100mL in 5min
1.0% sodium citrate solution, stirs evenly, and anticoagulated whole blood is obtained by filtration with double gauze；
B, anticoagulated whole blood described in 10mL is taken, is centrifuged at 0-4 DEG C using refrigerated centrifuge, upper plasma is collected, in magnetic force
Stirring and dissolving 1h obtains plasma protein solution under the action of blender, and lower layer's haemocyte recycling is for use；
C, curcumin is dissolved in the organic solvent of ethyl alcohol and 0.2mg/mL curcumin solution is made, by blood plasma egg in step b
White solution obtains plasma protein-curcumin polymer solution with curcumin solution mixing homogeneous；
D, plasma protein described in step c-curcumin polymer solution is added back in haemocyte, is stirred evenly；Again upwards
State addition a concentration of 25mg/mL calcium chloride solutions of 12.5mL in solution；The plasma protein-curcumin polymer solution and chlorination
The volume ratio of calcium solution and the anticoagulated whole blood is 1:8；
E, step d acquired solutions are put into 75 DEG C of thermostat water baths and heat 20min to complete solidification to get anti-oxidant ginger
Flavine Bean curd with duck blood.
Using test method described in embodiment 1 to the property of the anti-oxidant curcumin Bean curd with duck blood manufactured in the present embodiment
It can be tested, as shown in table 1.
Comparative example 2
This comparative example provides a kind of preparation method of anti-oxidant curcumin Bean curd with duck blood, compared with Example 1, difference
It is, calcium chloride is added without in the preparation process of the anti-oxidant curcumin Bean curd with duck blood.
Using test method described in embodiment 1 to the property of the anti-oxidant curcumin Bean curd with duck blood manufactured in the present embodiment
It can be tested, as shown in table 1.
Test result
Using curcumin embedding rate described in embodiment 1 and the assay method of load factor, plasma protein-curcumin polymer
Solution is to the assay method of the test method of the external clearance test of DPPH free radicals, inoxidizability reserving degree to anti-oxidant ginger
Flavine Bean curd with duck blood is tested, and the results are shown in Table 1：
1 test result summary sheet of table
From table 1 it follows that the anti-oxidant curcumin Bean curd with duck blood being prepared using method of the present invention
Embedding rate, load factor are higher, improve stability and the shelf-life of the curcumin active constituent, and product elasticity is good；At this
The concentration for inventing variation calcium chloride solution in the range, can make DPPH clearance rates and inoxidizability reserving degree higher,
It enhances the intestinal absorption of the curcumin and cell absorbs, extends curcumin residence time in blood, enhances
Anticancer effect；Comparative example 1 dissolves the curcumin using organic solvent keeps itself and protein binding, embedding rate, load factor relatively low；
Comparative example 2 in preparation process without using calcium chloride make the curcumin DPPH clearance rates and inoxidizability reserving degree compared with
It is low, product poor flexibility.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (7)
1. a kind of anti-oxidant curcumin Bean curd with duck blood, which is characterized in that include the raw material of following parts by weight：
80-100 parts of duck blood；
0.2-0.6 parts of curcumin.
2. the preparation method of anti-oxidant curcumin Bean curd with duck blood described in claim 1, which is characterized in that include the following steps：
A, anticoagulated whole blood is prepared：Duck blood is collected when duck is butchered immediately, sodium citrate solution is added into duck blood in 5min, is stirred
Filtering after uniformly collects filtrate and obtains anticoagulated whole blood；
B, blood plasma detaches：It taking the anticoagulated whole blood to centrifuge, collects upper plasma, dilution, stirring 1-2h obtain plasma protein solution,
Lower layer's haemocyte recycling is for use；
C, hydrophobic assembling：The pH value of plasma protein solution described in regulating step b is incubated 20-60min to 10-12, and curcumin is added
Particle is protected from light stirring 20-60min, adjusts pH to neutrality, obtains plasma protein-curcumin polymer solution；
D, thrombin activation：Plasma protein described in step c-curcumin polymer solution is added in the haemocyte described in step b,
It is uniformly mixing to obtain the whole blood containing plasma protein-curcumin polymer；Calcium chloride solution is added into above-mentioned solution again；Institute
The volume ratio for stating whole blood and calcium chloride solution containing plasma protein-curcumin polymer is 7-10:1-3；
E, heat-shaping：Step d acquired solutions are put into thermostat water bath and are heated to solidifying to get anti-oxidant curcumin completely
Bean curd with duck blood.
3. the preparation method of anti-oxidant curcumin Bean curd with duck blood according to claim 2, which is characterized in that in step a, institute
State a concentration of 0.9%-1.0% of sodium citrate solution.
4. the preparation method of anti-oxidant curcumin Bean curd with duck blood according to claim 2, which is characterized in that in step c, institute
The addition for stating curcumin is 0.2-0.6g/100mL on the basis of anticoagulated whole blood.
5. the preparation method of anti-oxidant curcumin Bean curd with duck blood according to claim 2, which is characterized in that in step c, adjust
Save the pH value tune 12 of plasma protein solution described in step b.
6. the preparation method of anti-oxidant curcumin Bean curd with duck blood according to claim 2, which is characterized in that in step d, institute
The concentration for stating calcium chloride solution is 25-30mg/mL on the basis of anticoagulated whole blood；It is described containing plasma protein-curcumin polymer
The volume ratio of whole blood and calcium chloride solution is 8：1.
7. the preparation method of anti-oxidant curcumin Bean curd with duck blood according to claim 2, which is characterized in that in step e, institute
The actual conditions for stating heating are：15-20min is heated at 70-80 DEG C.
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