CN108578787A - A kind of absorbable bone anchoring device and preparation method thereof - Google Patents
A kind of absorbable bone anchoring device and preparation method thereof Download PDFInfo
- Publication number
- CN108578787A CN108578787A CN201810888658.9A CN201810888658A CN108578787A CN 108578787 A CN108578787 A CN 108578787A CN 201810888658 A CN201810888658 A CN 201810888658A CN 108578787 A CN108578787 A CN 108578787A
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- China
- Prior art keywords
- anchoring device
- bone anchoring
- matrix
- ceramic
- bone
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 45
- 238000004873 anchoring Methods 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000011159 matrix material Substances 0.000 claims abstract description 25
- 239000000919 ceramic Substances 0.000 claims abstract description 23
- 229920000642 polymer Polymers 0.000 claims abstract description 20
- 229920000728 polyester Polymers 0.000 claims abstract description 17
- 239000000463 material Substances 0.000 claims abstract description 9
- 238000001727 in vivo Methods 0.000 claims abstract description 5
- 229920001610 polycaprolactone Polymers 0.000 claims description 9
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 5
- 239000001506 calcium phosphate Substances 0.000 claims description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 4
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 4
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 4
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 4
- 229920000954 Polyglycolide Polymers 0.000 claims description 3
- 239000004633 polyglycolic acid Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- MWKXCSMICWVRGW-UHFFFAOYSA-N calcium;phosphane Chemical compound P.[Ca] MWKXCSMICWVRGW-UHFFFAOYSA-N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- -1 ploy DL lactic caid Polymers 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 abstract description 4
- 239000002253 acid Substances 0.000 abstract description 4
- 230000004054 inflammatory process Effects 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 4
- 230000015556 catabolic process Effects 0.000 abstract description 3
- 238000006731 degradation reaction Methods 0.000 abstract description 3
- 230000035876 healing Effects 0.000 abstract description 3
- 210000004409 osteocyte Anatomy 0.000 abstract description 3
- 239000000654 additive Substances 0.000 abstract description 2
- 230000000996 additive effect Effects 0.000 abstract description 2
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 230000008468 bone growth Effects 0.000 abstract description 2
- 230000006698 induction Effects 0.000 abstract description 2
- 238000000053 physical method Methods 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract 1
- 239000004626 polylactic acid Substances 0.000 description 11
- 229920000747 poly(lactic acid) Polymers 0.000 description 10
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229930182843 D-Lactic acid Natural products 0.000 description 1
- JVTAAEKCZFNVCJ-UWTATZPHSA-N D-lactic acid Chemical compound C[C@@H](O)C(O)=O JVTAAEKCZFNVCJ-UWTATZPHSA-N 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229940022769 d- lactic acid Drugs 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/026—Ceramic or ceramic-like structures, e.g. glasses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
Abstract
The invention discloses a kind of absorbable bone anchoring device and preparation method thereof, feature is the matrix for including material for polyester polymer, and cavity is provided in matrix, Ca-P ceramic is filled in cavity；Advantage is to fill Ca-P ceramic composition in polyester polymer with physical method, so that the weight ratio of Ca-P ceramic composition reaches as high as 80% or so in bone anchoring device, this aspect can keep the microstructure of polymer, can reach high intensity using a small amount of polymer；On the other hand, promoting the additive amount of the Ca-P ceramic of bone uptake can be added according to actual needs.And after the bone anchoring device enters in vivo, material neutralizes for the acid alkaline Ca-P ceramic that can be filled formed after the matrix degradation of polyester polymer, to prevent inflammatory reaction, Ca-P ceramic therein can also play the function of induction osteocyte/bone growth simultaneously, accelerate the reparation and healing of bone, avoid formation empty in Regenerated Bone, it is ensured that the intensity of Regenerated Bone.
Description
Technical field
The present invention relates to used in clinical treatment bone fixation instrument more particularly to a kind of absorbable bone anchoring device
And preparation method thereof.
Background technology
Adsorbable bone fixing device based on polylactic acid is more and more widely used in clinical treatment.It is bone, soft
Polylactic acid-based absorbable fixed instrument is used extensively in the connection and fixation of bone, tendon, ligament etc..Polylactic acid is in vivo in environment
Lactic acid can be degraded to：D-lactic acid can be metabolized as carbon dioxide and water in human body by tricarboxylic acid cycle, and body is finally discharged
Outside；L-lactic acid can be excluded through kidney.Polylactic acid-based bone fixation medical instrument alternative metals class instrument can remove patient experience from
Second operation takes out pain and the financial burden of metal.But the bone anchoring devices such as pure made nail of polylactic acid material make
With finding that there are still problems in the process：（1）, polylactic acid catabolite in acidity, easily cause caused by acidity in vivo
Inflammatory reaction hinders symphysis and reparation；（2）, polylactic acid catabolite habitat be due to osteocyte/bone tissue can not be grown into
Cavity is formed, and then reduces the intensity of new bone, there are the risks of second fracture；（3）, poly-lactic acid material mechanical property to heat it is non-
Often sensitive, on the one hand the melting injection molding method routinely used accelerates the thermal degradation of polylactic acid ontology, substantially reduce its molecule
Amount, on the other hand, because polylactic acid crystallization rate itself is slow, conventional injection molding cooling allows it that can not form effective crystallization（Crystallinity
It is directly proportional to product strength）, the intensity that the factor of these two aspects results in polylactic acid-based bone anchoring device is low, cannot meet orthopaedics
Demand.
Invention content
Technical problem to be solved by the invention is to provide inflammatory reaction caused by a kind of acidity of avoidable catabolite,
The reparation and healing for accelerating bone prevent cavity in bone, and are greatly improved the absorbable bone anchoring device of device intensity
And preparation method thereof.
Technical solution is used by the present invention solves above-mentioned technical problem：A kind of absorbable bone anchoring device, including
Material is the matrix of polyester polymer, and cavity is provided in the matrix, Ca-P ceramic is filled in the cavity.
Further, the shape of the matrix is round bar shape or plate.
Further, the outer surface of the matrix of the round bar shape is provided with external screw thread.
Further, the polyester polymer is poly-epsilon-caprolactone, Poly L-lactic acid, ploy DL lactic caid, polyethanol
At least one of acid, wherein：The molecular weight of poly-epsilon-caprolactone>80000.
Further, the Ca-P ceramic is at least one of tricalcium phosphate, hydroxyapatite, bio-vitric.
A kind of preparation method of absorbable bone anchoring device, including step in detail below：
（1）, take solid polyester polymer to be processed into round bar shape or plate, as matrix；
（2）, on matrix trepanning to form inner cavity；
（3）, fill Ca-P ceramic in the lumen, obtain bone anchoring device.
Further, the step（1）In, screw thread is processed in the outer surface of the matrix of round bar shape, forms screw.
Further, the polyester polymer is poly-epsilon-caprolactone, Poly L-lactic acid, ploy DL lactic caid, polyethanol
At least one of acid, wherein：The molecular weight of poly-epsilon-caprolactone>80000.
Further, the Ca-P ceramic is at least one of tricalcium phosphate, hydroxyapatite, bio-vitric.
Compared with prior art, it is an advantage of the invention that：
（1）, due to material be polyester polymer matrix cavity in fill Ca-P ceramic, with physical method in polyesters
Ca-P ceramic composition is filled in polymer so that the weight ratio of Ca-P ceramic composition reaches as high as 80% or so in bone anchoring device,
This aspect can keep the microstructure of polymer, can reach high intensity using a small amount of polymer；On the other hand, promote bone life
The additive amount of long Ca-P ceramic can be added according to actual needs.
（2）, after the bone anchoring device enters in vivo, material be polyester polymer matrix degradation after the acidity that is formed can
The alkaline Ca-P ceramic that is filled neutralizes, to prevent inflammatory reaction, while Ca-P ceramic therein can also play induction osteocyte/
The function of bone growth accelerates the reparation and healing of bone, avoids formation empty in Regenerated Bone, it is ensured that Regenerated Bone it is strong
Degree.
Description of the drawings
Fig. 1 is the structural diagram of the present invention.
Specific implementation mode
Below in conjunction with attached drawing embodiment, present invention is further described in detail.
As shown, a kind of absorbable bone anchoring device, including matrix 1 that material is polyester polymer, in matrix 1
It is provided with cavity, Ca-P ceramic 2 is filled in cavity.
In above-described embodiment, the shape of matrix can be round bar shape or plate, also can be in the outer surface of the matrix of round bar shape
External screw thread is set, it is made to be used as nail；In addition, polyester polymer is poly-epsilon-caprolactone, Poly L-lactic acid, poly- racemization breast
At least one of acid, polyglycolic acid, wherein：The molecular weight of poly-epsilon-caprolactone>80000；Ca-P ceramic is tricalcium phosphate, hydroxyl
At least one of apatite, bio-vitric.
The preparation method of above-mentioned absorbable bone anchoring device, including step in detail below：
（1）, take solid polyester polymer to be processed into round bar shape or plate, as matrix 1；
（2）, on matrix 1 trepanning to form inner cavity；
（3）, in the lumen fill Ca-P ceramic 2, obtain bone anchoring device.
When needing using bone anchoring device as nail in use, in step（1）In, in the outer surface of the matrix 1 of round bar shape
Process screw thread.
Claims (9)
1. a kind of absorbable bone anchoring device, it is characterised in that including the matrix that material is polyester polymer, the base
It is provided with cavity in vivo, Ca-P ceramic is filled in the cavity.
2. a kind of absorbable bone anchoring device as described in claim 1, it is characterised in that：The shape of the matrix is circle
Stick or plate.
3. a kind of absorbable bone anchoring device as claimed in claim 2, it is characterised in that：The matrix of the round bar shape
Outer surface is provided with external screw thread.
4. a kind of absorbable bone anchoring device as described in claim 1, it is characterised in that：The polyester polymer is
At least one of poly-epsilon-caprolactone, Poly L-lactic acid, ploy DL lactic caid, polyglycolic acid, wherein：The molecular weight of poly-epsilon-caprolactone
>80000。
5. a kind of absorbable bone anchoring device as described in claim 1, it is characterised in that：The Ca-P ceramic is phosphoric acid
At least one of tricalcium, hydroxyapatite, bio-vitric.
6. a kind of preparation method of absorbable bone anchoring device, it is characterised in that including step in detail below：
（1）, take solid polyester polymer to be processed into round bar shape or plate, as matrix；
（2）, on matrix trepanning to form inner cavity；
（3）, fill Ca-P ceramic in the lumen, obtain bone anchoring device.
7. a kind of preparation method of absorbable bone anchoring device as claimed in claim 6, it is characterised in that：The step
（1）In, screw thread is processed in the outer surface of the matrix of round bar shape, forms screw.
8. a kind of preparation method of absorbable bone anchoring device as claimed in claim 6, it is characterised in that：The polyester
Type of Collective object is poly-epsilon-caprolactone, Poly L-lactic acid, ploy DL lactic caid, at least one of polyglycolic acid, wherein：Poly- ε-is in oneself
The molecular weight of ester>80000.
9. a kind of preparation method of absorbable bone anchoring device as claimed in claim 6, it is characterised in that：The calcium phosphorus
Ceramics are at least one of tricalcium phosphate, hydroxyapatite, bio-vitric.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810888658.9A CN108578787A (en) | 2018-08-07 | 2018-08-07 | A kind of absorbable bone anchoring device and preparation method thereof |
| PCT/CN2018/121388 WO2020029502A1 (en) | 2018-08-07 | 2019-01-30 | Absorbable bone fixation device and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810888658.9A CN108578787A (en) | 2018-08-07 | 2018-08-07 | A kind of absorbable bone anchoring device and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108578787A true CN108578787A (en) | 2018-09-28 |
Family
ID=63623084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810888658.9A Pending CN108578787A (en) | 2018-08-07 | 2018-08-07 | A kind of absorbable bone anchoring device and preparation method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN108578787A (en) |
| WO (1) | WO2020029502A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020029502A1 (en) * | 2018-08-07 | 2020-02-13 | 宁波宝亭生物科技有限公司 | Absorbable bone fixation device and preparation method thereof |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2020029502A1 (en) | 2020-02-13 |
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