CN108578503A - A kind of antibacterial ointment and preparation method thereof for treating bleb - Google Patents
A kind of antibacterial ointment and preparation method thereof for treating bleb Download PDFInfo
- Publication number
- CN108578503A CN108578503A CN201810535886.8A CN201810535886A CN108578503A CN 108578503 A CN108578503 A CN 108578503A CN 201810535886 A CN201810535886 A CN 201810535886A CN 108578503 A CN108578503 A CN 108578503A
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- CN
- China
- Prior art keywords
- parts
- antibacterial ointment
- oil
- chinese
- saltcake
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002674 ointment Substances 0.000 title claims abstract description 30
- 208000002352 blister Diseases 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 45
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000003814 drug Substances 0.000 claims abstract description 18
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 17
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 16
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- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims abstract description 15
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- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims abstract description 12
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 11
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- MOOFYEJFXBSZGE-QJUDHZBZSA-N 1,2-bis[(z)-(4-chlorophenyl)methylideneamino]guanidine Chemical group C=1C=C(Cl)C=CC=1\C=N/N=C(/N)N\N=C/C1=CC=C(Cl)C=C1 MOOFYEJFXBSZGE-QJUDHZBZSA-N 0.000 description 1
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Classifications
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- Molecular Biology (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of antibacterial ointment and preparation method thereof for treating bleb, belong to treatment shingles medications technical field, the parts by weight of each component are 4 ~ 7 parts of raw rhubarb, 3 ~ 6 parts of Cortex Phellodendri, 1 ~ 3 part of indigo naturalis, 2 ~ 4 parts of Chinese gall, 2 ~ 4 parts of saltcake, 2 ~ 4 parts of realgar, 3 ~ 6 parts of Asian puccoon, 2 ~ 4 parts of frankincense, 2 ~ 4 parts of myrrh, 1 ~ 3 part of borneol, 20 ~ 30 parts of castor oil, 2 ~ 5 parts of acetic acid chlorhexidine, 1 ~ 2 part of lauryl sodium sulfate, 2 ~ 5 parts of vitamin E oil, 1 ~ 3 part of glycerin monostearate；The present invention is that the understanding and principle of reatment with doctor trained in Western medicine to herpes episodes mechanism, selected Chinese and western medical raw material are formulated using unique formula based on modern Chinese medicine；When treatment, this appropriate antibacterial ointment is smeared in affected part, once a day or twice, a month as a course for the treatment of, and usual one month takes effect, and can cure within 1~5 month；The antibacterial ointment furfur, antipruritic effect are good, control difficulty in relapse after healing, have no toxic side effect.
Description
Technical field
The present invention relates to a kind of ointment and preparation method thereof, and in particular to a kind of antibacterial ointment that treating bleb and its preparation
Method belongs to treatment shingles medications technical field.
Background technology
Herpes zoster is the acute skin mucosa infection disease caused by varicella virus (VZV).Clinically
By it is occurring suddenly, along neural zonal distribution, unilateral distribution, dense clusters bleb with the characteristics of, pain is apparent, more after it is few multiple
Hair.This disease infectiousness very little, Patients with Herpes Zoster cannot directly propagate herpes zoster virus, but water can be caused in Susceptible population
Acne is popular.Its route of transmission is still " skin-air-respiratory tract ".It is varicella that children, which infect VZV (initial infection) clinical manifestation,
Adult shows as herpes zoster.Herpes zoster infection accounts for about 10%~20% in adult, but common with the elderly and immune deficiency person.
Partial trauma, part system disease and acute and chronic infectious disease and poisoning etc. are common precipitating factor.
Herpes zoster is a kind of common disease.Spring and autumn is multiple, and children are more rare.Can there are fever, general malaise etc. before the onset
Premonitory symptom.Ipsilateral skin begins with burn feeling, pain, and localised tension increases.Followed by there is irregular erythema successively in skin, at
The bleb of cluster around has blush, incrustation in 7~10 days to fall off in the grain grain transparent blister of size, heals within most 2~4 weeks.VZV can be invaded
Criminal face, neck, chest, lumbar nerves, 15%~20% invades trigeminal neuralgia, under rare occasion, can invade kinesitherapy nerve, such as face god
Through.Severe one can Complicating Pneumonia In Patients, meningitis.According to the nerve invaded, bleb is in characteristic zonal distribution, mostly unilateral, no
More than center line.If VZV invades first, conjunctivitis, keratitis can occur.It, can generating surface if invading facial nerve geniculate ganglion
Paralysis, external auditory canal earflap pain, herpes auris, pars oralis pharyngis bleb, tinnitus, sense of taste decline etc., referred to as geniculate ganglion integrates
Sign.Herpes zoster increases with the age, and symptom also aggravates, and the course of disease extends.Some patients still have neuropathic pain conditions after bleb healing
Periods of months or longer time.
Herpes zoster conventional therapy has antiviral therapy, immunopotentiation therapy, antibacterial, anti-inflammatory, analgesia therapy, part to control
It treats.Chinese medicine discusses the etiology and pathogenesis of this disease a lot of, it is considered that with wind, wet, hot, evil related, mostly by retention of damp-heat in the interior, impression poison
Heresy, Shi Re Bing Pian are fought mutually knot, and it is to suffer to stop up stagnant skin.Herpes zoster is equivalent to " herpes zostor " of Chinese medicine, is commonly called as " skirt-roof dragon ",
Generally mostly fall ill in spring.Chinese medicine is treated by diagnosis and treatment based on an overall analysis of the illness and the patient's condition, the modes such as clearing heat and promoting diuresis, removing toxic substances, achieves very big effect, therefore
The present invention proposes a kind of antibacterial ointment for treating bleb, uses traditional Chinese medicine ingredients, is free from side effects, uneasy to recur, curative effect is made us
It is satisfied.
Invention content
The present invention is and to propose a kind of antibacterial, anti-inflammatory anti-itch good effect to solve the problems, such as the treatment of current herpes zoster,
The antibacterial ointment for the treatment of bleb without side-effects.Various Chinese medicine materials are mainly ground into powder by the antibacterial ointment, then with grease,
Emulsifier and thickener heat together to be melted, emulsifies uniform and manufactured, easy to use and smearing.
To achieve the above object, the present invention adopts the following technical scheme that：
A kind of antibacterial ointment for treating bleb, which is characterized in that the parts by weight of each component are：
4 ~ 7 parts of raw rhubarb, 3 ~ 6 parts of Cortex Phellodendri, 1 ~ 3 part of indigo naturalis, 2 ~ 4 parts of Chinese gall, 2 ~ 4 parts of saltcake, 2 ~ 4 parts of realgar, Asian puccoon 3 ~ 6
Part, 2 ~ 4 parts of frankincense, 2 ~ 4 parts of myrrh, 1 ~ 3 part of borneol, 20 ~ 30 parts of castor oil, 2 ~ 5 parts of acetic acid chlorhexidine, lauryl sodium sulfate
1 ~ 2 part, 2 ~ 5 parts of vitamin E oil, 1 ~ 3 part of glycerin monostearate；
5 ~ 7 parts of raw rhubarb, 3 ~ 4 parts of Cortex Phellodendri, 1 ~ 2 part of indigo naturalis, 2 ~ 3 parts of Chinese gall, 2 ~ 3 parts of saltcake, 2 ~ 3 parts of realgar, Asian puccoon 3 ~ 4
Part, 2 ~ 3 parts of frankincense, 2 ~ 3 parts of myrrh, 1 ~ 2 part of borneol, 20 ~ 30 parts of castor oil, 2 ~ 3 parts of acetic acid chlorhexidine, lauryl sodium sulfate
1 ~ 2 part, 2 ~ 5 parts of vitamin E oil, 1 ~ 3 part of glycerin monostearate；
4 ~ 6 parts of raw rhubarb, 5 ~ 6 parts of Cortex Phellodendri, 2 ~ 3 parts of indigo naturalis, 3 ~ 4 parts of Chinese gall, 3 ~ 4 parts of saltcake, 3 ~ 4 parts of realgar, Asian puccoon 3 ~ 4
Part, 2 ~ 3 parts of frankincense, 2 ~ 3 parts of myrrh, 1 ~ 2 part of borneol, 20 ~ 30 parts of castor oil, 2 ~ 3 parts of acetic acid chlorhexidine, lauryl sodium sulfate
1 ~ 2 part, 2 ~ 5 parts of vitamin E oil, 1 ~ 3 part of glycerin monostearate.
A kind of antibacterial ointment preparation method for treating bleb, which is characterized in that including following preparation process：
（1）It crushes：By Chinese medicine materials such as raw rhubarb, Cortex Phellodendri, indigo naturalis, Chinese gall, saltcake, realgar, Asian puccoon, frankincense, myrrh, borneols
It is ground into fine powder with pulverizer；
（2）Decoction filtering：The purified water of 20 times of amounts of raw material gross weight is added in fine powder, decocts 2 ~ 3h, filtrate is collected in filtering；
The water that 8 ~ 15 times of amounts of medicinal material weight are added in the dregs of a decoction again decocts 1 ~ 2h, and filtrate is collected in filtering, filtrate will merge twice；
（3）Concentration：The heating of above-mentioned filtrate is concentrated into the medicinal extract of semisolid；
（4）Drying and crushing：It by medicinal extract freeze-drying at solid, crushes, crosses 200 mesh sieve, obtain Chinese medicinal powder；
（5）Melt emulsification：It takes castor oil and acetic acid chlorhexidine to be heated in 70~80 DEG C of water-baths, melts, stir evenly, then
Lauryl sodium sulfate, vitamin E oil and glycerin monostearate is added, heating fusing stirs evenly, obtains emulsion；
（6）Mixing：Chinese medicinal powder is added in above-mentioned emulsion, stirs evenly and cools down to get the antibacterial ointment.
The pharmacological property of the raw materials used in the present invention is as follows：
Raw rhubarb：Attack stagnant, clearing away damp-heat, purging intense heat, cool blood, dissolving stasis, removing toxic substances；
Cortex Phellodendri：Heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment；
Indigo naturalis：It is clearing heat and detoxicating, blood cooling and ecchymoses removing, purging intense heat arresting convulsion；
Chinese gall：Astringe the lung fall fire, relieving diarrhea with astringents, arrest sweating hemostasis, hygroscopic sore；
Saltcake：Moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat；
Realgar：Antibacterial antivirus；
Asian puccoon：Cool blood, promoting blood circulation, heat-clearing, removing toxic substances；
Frankincense：Blood-activating and qi-promoting relieves pain, detumescence and promoting granulation；
Myrrh：Scattered stasis pain, detumescence and promoting granulation；
Borneol：Heat-clearing dissipates poison；
Castor oil：Purging intense heat, except steaming, detoxification sore treatment；
Chlorhexidine acetate：Also it is Robenidine Roripa, chlorhexidine acetate, Chlorhexidine, double benzyl chloride chlorhexidine, for cation
Surfactant, has a broad antifungal spectrum have killing effect to most Grain-positives and negative bacteria, also effective to Pseudomonas aeruginosa, use
In operation remote holder, skin, planing surface and sterilization of instruments.
The invention has the advantages that and advantageous effect：
The present invention is based on modern Chinese medicines and doctor trained in Western medicine to the pathogenetic understanding of herpes zoster and principle of reatment, selected traditional Chinese and western medicine drug
Raw material is formulated using unique formula；When treatment, external application smears this appropriate antibacterial ointment in affected part, once a day or two
Secondary, a month as a course for the treatment of, and usual one month takes effect, and can cure within 1~5 month；The antibacterial ointment furfur, antipruritic effect are good, control
Difficulty in relapse after healing has no toxic side effect.
Specific implementation mode
Product of the present invention is further described below in conjunction with the embodiment of the present invention, the description of embodiment is only for ease of understanding
With with the application of the invention, rather than to the limitation protected of the present invention.Unless stated otherwise, preparation process under room temperature, normal pressure state into
Row；Unless stated otherwise, the reagent that is used in the present invention, method and apparatus is the art conventional reagent, method and apparatus；
Unless stated otherwise, the experimental condition used in the present invention is the art normal test conditions；Unless stated otherwise, this hair
Bright middle agents useful for same is purchased in market.
Embodiment 1
A kind of antibacterial ointment for treating bleb, the parts by weight of each component are：
4 parts of raw rhubarb, 6 parts of Cortex Phellodendri, 3 parts of indigo naturalis, 4 parts of Chinese gall, 4 parts of saltcake, 4 parts of realgar, 6 parts of Asian puccoon, 4 parts of frankincense, myrrh 4
Part, 3 parts of borneol, 30 parts of castor oil, 4 parts of acetic acid chlorhexidine, 2 parts of lauryl sodium sulfate, 4 parts of vitamin E oil, monostearate is sweet
2 parts of grease；
A kind of antibacterial ointment preparation method for treating bleb, including following preparation process：
（1）It crushes：By Chinese medicine materials such as raw rhubarb, Cortex Phellodendri, indigo naturalis, Chinese gall, saltcake, realgar, Asian puccoon, frankincense, myrrh, borneols
It is ground into fine powder with pulverizer；
（2）Decoction filtering：The purified water of 20 times of amounts of raw material gross weight is added in fine powder, decocts 2 ~ 3h, filtrate is collected in filtering；
The water that 8 ~ 15 times of amounts of medicinal material weight are added in the dregs of a decoction again decocts 1 ~ 2h, and filtrate is collected in filtering, filtrate will merge twice；
（3）Concentration：The heating of above-mentioned filtrate is concentrated into the medicinal extract of semisolid；
（4）Drying and crushing：It by medicinal extract freeze-drying at solid, crushes, crosses 200 mesh sieve, obtain Chinese medicinal powder；
（5）Melt emulsification：It takes castor oil and acetic acid chlorhexidine to be heated in 70~80 DEG C of water-baths, melts, stir evenly, then
Lauryl sodium sulfate, vitamin E oil and glycerin monostearate is added, heating fusing stirs evenly, obtains emulsion；
（6）Mixing：Chinese medicinal powder is added in above-mentioned emulsion, stirs evenly and cools down to get the antibacterial ointment.
Embodiment 2
A kind of antibacterial ointment for treating bleb, the parts by weight of each component are：
5 parts of raw rhubarb, 5 parts of Cortex Phellodendri, 2 parts of indigo naturalis, 3 parts of Chinese gall, 3 parts of saltcake, 3 parts of realgar, 4 parts of Asian puccoon, 3 parts of frankincense, myrrh 3
Part, 2 parts of borneol, 28 parts of castor oil, 4 parts of acetic acid chlorhexidine, 2 parts of lauryl sodium sulfate, 4 parts of vitamin E oil, monostearate is sweet
2 parts of grease；
A kind of antibacterial ointment preparation method for treating bleb, including following preparation process：
（1）It crushes：By Chinese medicine materials such as raw rhubarb, Cortex Phellodendri, indigo naturalis, Chinese gall, saltcake, realgar, Asian puccoon, frankincense, myrrh, borneols
It is ground into fine powder with pulverizer；
（2）Decoction filtering：The purified water of 20 times of amounts of raw material gross weight is added in fine powder, decocts 2 ~ 3h, filtrate is collected in filtering；
The water that 8 ~ 15 times of amounts of medicinal material weight are added in the dregs of a decoction again decocts 1 ~ 2h, and filtrate is collected in filtering, filtrate will merge twice；
（3）Concentration：The heating of above-mentioned filtrate is concentrated into the medicinal extract of semisolid；
（4）Drying and crushing：It by medicinal extract freeze-drying at solid, crushes, crosses 200 mesh sieve, obtain Chinese medicinal powder；
（5）Melt emulsification：It takes castor oil and acetic acid chlorhexidine to be heated in 70~80 DEG C of water-baths, melts, stir evenly, then
Lauryl sodium sulfate, vitamin E oil and glycerin monostearate is added, heating fusing stirs evenly, obtains emulsion；
（6）Mixing：Chinese medicinal powder is added in above-mentioned emulsion, stirs evenly and cools down to get the antibacterial ointment.
Embodiment 3
A kind of antibacterial ointment for treating bleb, the parts by weight of each component are：
7 parts of raw rhubarb, 3 parts of Cortex Phellodendri, 1 part of indigo naturalis, 2 parts of Chinese gall, 2 parts of saltcake, 2 parts of realgar, 3 parts of Asian puccoon, 2 parts of frankincense, myrrh 2
Part, 1 part of borneol, 25 parts of castor oil, 4 parts of acetic acid chlorhexidine, 2 parts of lauryl sodium sulfate, 4 parts of vitamin E oil, monostearate is sweet
2 parts of grease；
A kind of antibacterial ointment preparation method for treating bleb, including following preparation process：
（1）It crushes：By Chinese medicine materials such as raw rhubarb, Cortex Phellodendri, indigo naturalis, Chinese gall, saltcake, realgar, Asian puccoon, frankincense, myrrh, borneols
It is ground into fine powder with pulverizer；
（2）Decoction filtering：The purified water of 20 times of amounts of raw material gross weight is added in fine powder, decocts 2 ~ 3h, filtrate is collected in filtering；
The water that 8 ~ 15 times of amounts of medicinal material weight are added in the dregs of a decoction again decocts 1 ~ 2h, and filtrate is collected in filtering, filtrate will merge twice；
（3）Concentration：The heating of above-mentioned filtrate is concentrated into the medicinal extract of semisolid；
（4）Drying and crushing：It by medicinal extract freeze-drying at solid, crushes, crosses 200 mesh sieve, obtain Chinese medicinal powder；
（5）Melt emulsification：It takes castor oil and acetic acid chlorhexidine to be heated in 70~80 DEG C of water-baths, melts, stir evenly, then
Lauryl sodium sulfate, vitamin E oil and glycerin monostearate is added, heating fusing stirs evenly, obtains emulsion；
（6）Mixing：Chinese medicinal powder is added in above-mentioned emulsion, stirs evenly and cools down to get the antibacterial ointment.
Acquire clinic case：
Case 1, patient Wu, man, 52 years old, Hubei people from Wuhan suffered from herpes zoster (damp-heat type), preceding 3 days waist parts skin of going to a doctor
Skin is scorching hot, pain, and then erythema occurs in skin, and papule rapidly goes to bubble, and about mung bean is big.External application drug therapy of the present invention, 10
Symptom completely disappears after it, and local pigment calmness is without scar, the no positive sign of whole body, and follow-up 1 year is without recurrence.
Case 2, patient Liu, female, 43 years old, Hubei people from Wuhan suffered from herpes zoster, and external application drug therapy of the present invention is fullyed recover from an illness for 15 days
More, follow-up is not recurred for 1 year.
Case 3, patient's week certain, man, 35 years old, there is unilateral band-like erythema in people from Guangzhou Guangdong, local skin, is diagnosed as band-like
The ointment of bleb, the external application present invention is smeared, and symptom disappears quickly, is continuing with a period of time, recovery from illness, and follow-up is not recurred for 1 year.
The above is only the application implementation mode of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the technical principles of the invention, several improvements and modifications can also be made, these improvements and modifications
Also it should be regarded as protection scope of the present invention.
Claims (4)
1. a kind of antibacterial ointment for treating bleb, which is characterized in that the parts by weight of each component are：
4 ~ 7 parts of raw rhubarb, 3 ~ 6 parts of Cortex Phellodendri, 1 ~ 3 part of indigo naturalis, 2 ~ 4 parts of Chinese gall, 2 ~ 4 parts of saltcake, 2 ~ 4 parts of realgar, Asian puccoon 3 ~ 6
Part, 2 ~ 4 parts of frankincense, 2 ~ 4 parts of myrrh, 1 ~ 3 part of borneol, 20 ~ 30 parts of castor oil, 2 ~ 5 parts of acetic acid chlorhexidine, lauryl sodium sulfate
1 ~ 2 part, 2 ~ 5 parts of vitamin E oil, 1 ~ 3 part of glycerin monostearate.
2. a kind of antibacterial ointment for treating bleb, which is characterized in that the parts by weight of each component are：
5 ~ 7 parts of raw rhubarb, 3 ~ 4 parts of Cortex Phellodendri, 1 ~ 2 part of indigo naturalis, 2 ~ 3 parts of Chinese gall, 2 ~ 3 parts of saltcake, 2 ~ 3 parts of realgar, Asian puccoon 3 ~ 4
Part, 2 ~ 3 parts of frankincense, 2 ~ 3 parts of myrrh, 1 ~ 2 part of borneol, 20 ~ 30 parts of castor oil, 2 ~ 3 parts of acetic acid chlorhexidine, lauryl sodium sulfate
1 ~ 2 part, 2 ~ 5 parts of vitamin E oil, 1 ~ 3 part of glycerin monostearate.
3. a kind of antibacterial ointment for treating bleb, which is characterized in that the parts by weight of each component are：
4 ~ 6 parts of raw rhubarb, 5 ~ 6 parts of Cortex Phellodendri, 2 ~ 3 parts of indigo naturalis, 3 ~ 4 parts of Chinese gall, 3 ~ 4 parts of saltcake, 3 ~ 4 parts of realgar, Asian puccoon 3 ~ 4
Part, 2 ~ 3 parts of frankincense, 2 ~ 3 parts of myrrh, 1 ~ 2 part of borneol, 20 ~ 30 parts of castor oil, 2 ~ 3 parts of acetic acid chlorhexidine, lauryl sodium sulfate
1 ~ 2 part, 2 ~ 5 parts of vitamin E oil, 1 ~ 3 part of glycerin monostearate.
4. a kind of antibacterial ointment preparation method for treating bleb, which is characterized in that including following preparation process：
（1）It crushes：By Chinese medicine materials such as raw rhubarb, Cortex Phellodendri, indigo naturalis, Chinese gall, saltcake, realgar, Asian puccoon, frankincense, myrrh, borneols
It is ground into fine powder with pulverizer；
（2）Decoction filtering：The purified water of 20 times of amounts of raw material gross weight is added in fine powder, decocts 2 ~ 3h, filtrate is collected in filtering；
The water that 8 ~ 15 times of amounts of medicinal material weight are added in the dregs of a decoction again decocts 1 ~ 2h, and filtrate is collected in filtering, filtrate will merge twice；
（3）Concentration：The heating of above-mentioned filtrate is concentrated into the medicinal extract of semisolid；
（4）Drying and crushing：It by medicinal extract freeze-drying at solid, crushes, crosses 200 mesh sieve, obtain Chinese medicinal powder；
（5）Melt emulsification：It takes castor oil and acetic acid chlorhexidine to be heated in 70~80 DEG C of water-baths, melts, stir evenly, then
Lauryl sodium sulfate, vitamin E oil and glycerin monostearate is added, heating fusing stirs evenly, obtains emulsion；
（6）Mixing：Chinese medicinal powder is added in above-mentioned emulsion, stirs evenly and cools down to get the antibacterial ointment.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010565A (en) * | 2018-10-16 | 2018-12-18 | 广州博阳生物科技有限公司 | A kind of detoxification pain relieving liquid and preparation method thereof |
| CN111184777A (en) * | 2020-01-22 | 2020-05-22 | 司玉玲 | Emulsifiable paste for treating herpes and preparation method thereof |
| CN115501270A (en) * | 2022-11-23 | 2022-12-23 | 广州嘉德乐生化科技有限公司 | Monoglyceride-containing antibacterial ointment for treating herpes and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732462A (en) * | 2009-11-11 | 2010-06-16 | 宋爱民 | Chinese medicinal preparation for treating herpes zoster |
| CN107595901A (en) * | 2017-08-24 | 2018-01-19 | 曾辉煌 | Treat the Chinese medicine preparation of snake skirt-roof |
-
2018
- 2018-05-30 CN CN201810535886.8A patent/CN108578503A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732462A (en) * | 2009-11-11 | 2010-06-16 | 宋爱民 | Chinese medicinal preparation for treating herpes zoster |
| CN107595901A (en) * | 2017-08-24 | 2018-01-19 | 曾辉煌 | Treat the Chinese medicine preparation of snake skirt-roof |
Non-Patent Citations (6)
| Title |
|---|
| CHIEN-YUN HSIANG等: "Inhibitory Effect of Anti-pyretic and Anti-inflammatory Herbs on Herpes Simplex Virus Replication", 《AMERICAN JOURNAL OF CHINESE MEDICINE》 * |
| 何莉等: "《女性美容护肤秘诀》", 30 September 2012, 人民军医出版社 * |
| 吴景时: "《国家非处方药手册》", 31 August 2004, 人民卫生出版社 * |
| 徐承庆: "疱疹液治疗带状疱疹65例", 《国医论坛》 * |
| 朱运喜等: "中药外敷治疗带状疱疹80例", 《中医杂志》 * |
| 王光明等: "青黛散外用治疗带状疱疹158例", 《中国中医药现代远程教育》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010565A (en) * | 2018-10-16 | 2018-12-18 | 广州博阳生物科技有限公司 | A kind of detoxification pain relieving liquid and preparation method thereof |
| CN111184777A (en) * | 2020-01-22 | 2020-05-22 | 司玉玲 | Emulsifiable paste for treating herpes and preparation method thereof |
| CN115501270A (en) * | 2022-11-23 | 2022-12-23 | 广州嘉德乐生化科技有限公司 | Monoglyceride-containing antibacterial ointment for treating herpes and preparation method thereof |
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Application publication date: 20180928 |