CN108578023B - Graphene oxide heart blood vessel stent and preparation method thereof - Google Patents

Graphene oxide heart blood vessel stent and preparation method thereof Download PDF

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Publication number
CN108578023B
CN108578023B CN201810381592.4A CN201810381592A CN108578023B CN 108578023 B CN108578023 B CN 108578023B CN 201810381592 A CN201810381592 A CN 201810381592A CN 108578023 B CN108578023 B CN 108578023B
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graphene oxide
stent
end part
cardiovascular stent
grinding
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CN108578023A (en
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赵立春
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Guangxi University of Chinese Medicine
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Guangxi University of Chinese Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/082—Inorganic materials
    • A61L31/084—Carbon; Graphite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs

Abstract

The invention discloses a graphene oxide heart blood vessel stent and a preparation method thereof, wherein a rotary grinding and crushing bolt assembly is arranged on the basis of a traditional stent, in the blood flowing process, blood can push a spiral rib arranged on the inner wall of a rotating main body, so that the rotating main body can rotate, and when blood flows through, the rotating rib and a crushing blade can crush small thrombus flowing through; after the stent is implanted, the hyperplastic tissue on the inner wall of the blood vessel can also grow, and once the hyperplastic tissue grows and touches the rotational grinding bulge, the rotational grinding bulge can grind the touched hyperplastic tissue, so that the blood vessel at the position is prevented from being further blocked. Because the inside and outside surface of first end, second end, bracing piece and the broken bolt subassembly of grinding soon all coats and has oxidized graphene layer, oxidized graphene layer can carry out the efficient and disinfect, antibacterial, avoids leading to the inside inflammation that produces of blood vessel owing to the grinding to the hyperplasia tissue.

Description

Graphene oxide heart blood vessel stent and preparation method thereof
The technical field is as follows:
the invention relates to the technical field of medical instruments, in particular to a graphene oxide heart blood vessel stent and a preparation method thereof.
Background art:
the heart Stent (Stent), also called coronary artery Stent, is a medical instrument commonly used in the heart interventional operation, has the function of dredging artery vessels, and is mainly made of stainless steel, nickel-titanium alloy or cobalt-chromium alloy. The ideal stent has the characteristics of flexibility, good tracing property, small head end, no X-ray penetration, thrombus resistance, good biocompatibility, reliable expansion performance, good supporting force, good coverage, small surface area, accordance with hydromechanics and the like. The most important function of the existing heart stent is to play a supporting role, so as to support and expand the narrow position of the blood vessel, thereby facilitating the blood to pass through. Limited by the structure and the manufacturing material, the thrombus-eliminating implant can not be used for eliminating thrombus, sterilizing and inhibiting bacteria and avoiding the problem of overlarge growth of hyperplasia tissues on the inner wall of the blood vessel except the supporting effect after being implanted into a human body.
The invention content is as follows:
the invention aims to overcome the defects of the prior art and provides a graphene oxide heart blood vessel stent and a preparation method thereof.
The technical solution of the invention is as follows:
the graphene oxide heart blood vessel stent comprises a first end part and a second end part which have the same structure, wherein a plurality of supporting rods are connected between the first end part and the second end part, and the first end part, the second end part and the supporting rods form a stent main body and allow blood to pass through; a rotary grinding bolt assembly is arranged in the bracket main body, the rotary grinding bolt assembly is provided with a hollow cylindrical rotating main body, a plurality of uniformly distributed rotary grinding bulges are arranged on the outer wall of the rotating main body, a spiral convex edge is arranged on the inner wall of the rotating main body, and a crushing blade (not shown in the figure) is arranged on the convex edge; wherein, the inside and outside surface of first end, second end, bracing piece and the broken bolt subassembly of grinding soon all coats and is coated with graphite oxide layer.
The rotary grinding bulges are arranged on the outer wall of the rotating main body in rows and are of hemispherical structures.
The first end comprises an outer ring, the inner side of the outer ring is connected with a transition ring, the transition ring is connected with an inner ring, and the diameter of the inner ring is smaller than that of the outer ring.
The number of the supporting rods is six or eight, and two ends of the supporting rods are respectively fixed on the inner rings of the first end part and the second end part.
The tip of inner ring is provided with the spliced eye, and the quantity of spliced eye corresponds each other with the quantity of bracing piece, and the bracing piece is pegged graft in the spliced eye, is interference fit between bracing piece and the spliced eye.
The bracing piece is close to the both ends of first end, second end and is provided with the gag lever post towards the inside of support main part respectively, and the gag lever post restriction at both ends grinds garrulous bolt subassembly's moving range soon.
The first end part, the second end part and the support rod are made of polyethylene terephthalate, nylon, polyethylene, polyurethane or soft polyvinyl chloride.
The first end part, the second end part and the support rod can also be made of silicon resin, synthetic polyisoprene or latex.
The outer wall of the rotating body is also provided with a plurality of radiopaque marker elements, and the marker elements are made of radiopaque materials.
The outer surfaces of the first and second ends are provided with a textured surface that prevents migration of the stent body, the textured surface extending over a portion of the length and/or circumference of the first and second ends.
The textured surface is a series of bumps or grooves disposed on the outer surface of the first end or the second end.
The textured surface may be formed on the outer surface of the first end or the second end by scoring, grinding, abrading.
Be provided with fixed barb on the outer loop of first end, fixed barb's quantity is a plurality of, and a plurality of fixed barb evenly distributed is on the outer loop.
The outer ring is provided with a sliding groove, the sliding groove comprises a large groove arranged on the inner side of the outer surface of the outer ring, and the outer end of the large groove is communicated with the small groove.
The big inslot is provided with flexible bolster, and the end-to-end connection of flexible bolster has fixed barb.
The fixed barb includes the slider with flexible bolster fixed connection, and the slider slides and sets up at the macro-groove, fixedly connected with slide bar on the slider, and the slide bar slides along the sulculus, and the end-to-end connection of slide bar has the stationary dog, and the outward flange of stationary dog is provided with a plurality of barbs.
The fixed claw comprises a horizontal part, a first inclined part and a second inclined part which are sequentially connected, wherein the horizontal part is fixedly connected with the sliding rod, the barb is arranged on the outer edge of the second inclined part, the inclination angle of the first inclined part is 20-35 degrees, and the inclination angle of the second inclined part is 10-15 degrees.
On the basis of the above embodiment, the method for manufacturing the graphene oxide cardiovascular stent further comprises the following specific steps:
step S1, manufacturing a first end part, a second end part, a supporting rod, a rotary grinding bolt component, an elastic buffer part and a fixing barb;
step S2, coating the graphene oxide layer on the first end part, the second end part, the supporting rod and the rotary grinding bolt assembly;
step S3, assembling the first end portion, the second end portion, the support bar, the rotational grind key assembly, the elastic buffer, and the fixation barbs.
In step S2, the first end portion, the second end portion, the support rod, and the rotational grinding bolt assembly are placed in the sheet-like graphene nanosheet precursor solution, and the coating conditions are hydrothermal.
Wherein the hydrothermal temperature is 150 ℃ and 200 ℃, and the hydrothermal reaction time is 20-30 hours.
The invention has the beneficial effects that:
according to the invention, the rotational grinding bolt assembly is arranged on the basis of the traditional support, in the blood flowing process, blood can push the spiral convex edge arranged on the inner wall of the rotating main body, so that the rotating main body can rotate, and when blood flows through, the rotating convex edge and the crushing blade can crush small thrombus flowing through; after the stent is implanted, the hyperplastic tissue on the inner wall of the blood vessel can also grow, and once the hyperplastic tissue grows and touches the rotational grinding bulge, the rotational grinding bulge can grind the touched hyperplastic tissue, so that the blood vessel at the position is prevented from being further blocked. Because the inside and outside surface of first end, second end, bracing piece and the broken bolt subassembly of grinding soon all coats and has oxidized graphene layer, oxidized graphene layer can carry out the efficient and disinfect, antibacterial, avoids leading to the inside inflammation that produces of blood vessel owing to the grinding to the hyperplasia tissue.
Description of the drawings:
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of the first end portion;
FIG. 3 is a schematic structural view of the chute;
FIG. 4 is a schematic structural view of a rotational atherectomy bolt assembly;
figure 5 is a schematic view of the configuration of the fixation barbs.
The specific implementation mode is as follows:
in order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below.
As shown in fig. 1 to 5, a graphene oxide cardiovascular stent comprises a first end portion 11 and a second end portion 12 which have the same structure, wherein a plurality of support rods 13 are connected between the first end portion 11 and the second end portion 12, and the first end portion 11, the second end portion 12 and the plurality of support rods 13 form a stent body and allow blood to pass through; the inside of the bracket main body is provided with a rotary grinding bolt component 2, the rotary grinding bolt component 2 is provided with a hollow cylindrical rotary main body 20, the outer wall of the rotary main body 20 is provided with a plurality of uniformly distributed rotary grinding bulges 22, the inner wall of the rotary main body 20 is provided with a spiral convex rib 21, and the convex rib 21 is provided with a crushing blade (not shown in the figure); wherein the first end portion 11, the second end portion 12, the support rod 13 and the inner and outer surfaces of the grinding plug assembly 2 are coated with graphene oxide layers.
Due to the arrangement of the rotational grinding bolt assembly positioned in the stent main body, in the blood flowing process, blood can push the spiral convex edge arranged on the inner wall of the rotating main body 20, so that the rotating main body can rotate, and when blood flows through, the rotating convex edge and the crushing blade can crush small thrombus flowing through; after the stent is implanted, the hyperplastic tissue on the inner wall of the blood vessel can also grow, and once the hyperplastic tissue grows and touches the rotational grinding bulge, the rotational grinding bulge can grind the touched hyperplastic tissue, so that the blood vessel at the position is prevented from being further blocked.
Because the inner and outer surfaces of the first end portion 11, the second end portion 12, the support rod 13 and the grinding plug component 2 are coated with the graphene oxide layer, the graphene oxide layer can perform efficient sterilization and bacteriostasis, and inflammation caused by grinding of hyperplastic tissues in the blood vessel is avoided.
The rotational protrusions 22 are provided in a row on the outer wall of the rotational body 20, and the rotational protrusions 22 have a hemispherical structure.
The first end portion 11 includes an outer ring 111, a transition ring 112 is connected to the inner side of the outer ring 111, an inner ring 113 is connected to the transition ring 112, and the diameter of the inner ring 113 is smaller than that of the outer ring 111.
The number of the support rods 13 is six or eight, and both ends of the support rods 13 are fixed to the inner rings 113 of the first end portion 11 and the second end portion 12, respectively.
The tip of inner ring 113 is provided with the spliced eye, and the quantity of spliced eye corresponds each other with the quantity of bracing piece 13, and the bracing piece 13 is pegged graft in the spliced eye, is interference fit between bracing piece 13 and the spliced eye.
The two ends of the support rod 13 close to the first end portion 11 and the second end portion 12 are respectively provided with a limiting rod 131 facing the inside of the bracket main body, and the limiting rods 131 at the two ends limit the moving range of the rotational grinding bolt assembly 2.
The first end portion 11, the second end portion 12 and the support rod 13 are made of polyethylene terephthalate, nylon, polyethylene, polyurethane or soft polyvinyl chloride.
The first end 11, the second end 12 and the support rod 13 may also be made of silicone, synthetic polyisoprene or latex.
The outer wall of the rotating body 20 is also provided with a plurality of radiopaque marker elements (not shown) made of radiopaque material.
The outer surfaces of the first and second ends 11, 12 are provided with a textured surface that prevents migration of the stent body, the textured surface extending over a portion of the length and/or circumference of the first and second ends 11, 12.
The textured surface is a series of bumps or grooves disposed on the outer surface of the first end 11 or the second end 12.
The textured surface may be formed by scoring, grinding, abrading the outer surface of the first end 11 or the second end 12.
The outer ring 111 of the first end part 11 is provided with a plurality of fixing barbs 3, and the plurality of fixing barbs 3 are uniformly distributed on the outer ring 111.
The outer ring 111 is provided with a sliding groove which comprises a large groove 101 arranged on the inner side of the outer surface 110 of the outer ring 111, and the outer end of the large groove 101 is communicated with the small groove 102.
A telescopic buffer member 4 is arranged in the large groove 101, and the tail end of the telescopic buffer member 4 is connected with a fixing barb 3.
The fixing barb 3 comprises a sliding block 33 fixedly connected with the telescopic buffer part 4, the sliding block 33 is arranged in the large groove 101 in a sliding mode, a sliding rod 32 is fixedly connected onto the sliding block 33, the sliding rod 32 slides along the small groove 102, the tail end of the sliding rod 32 is connected with a fixing claw 31, and a plurality of barbs 34 are arranged on the outer edge of the fixing claw 31.
The fixed claw 31 comprises a horizontal part 311, a first inclined part 312 and a second inclined part 313 which are connected in sequence, wherein the horizontal part 311 is fixedly connected with the slide bar 32, the barbs 34 are arranged on the outer edge of the second inclined part 313, the inclination angle of the first inclined part 312 is 20-35 degrees, and the inclination angle of the second inclined part is 10-15 degrees.
On the basis of the above embodiment, the method for manufacturing the graphene oxide cardiovascular stent further comprises the following specific steps:
step S1, manufacturing a first end part, a second end part, a supporting rod, a rotary grinding bolt component, an elastic buffer part and a fixing barb;
step S2, coating the graphene oxide layer on the first end part, the second end part, the supporting rod and the rotary grinding bolt assembly;
step S3, assembling the first end portion, the second end portion, the support bar, the rotational grind key assembly, the elastic buffer, and the fixation barbs.
In step S2, the first end portion, the second end portion, the support rod, and the rotational grinding bolt assembly are placed in the sheet-like graphene nanosheet precursor solution, and the coating conditions are hydrothermal.
Wherein the hydrothermal temperature is 150 ℃ and 200 ℃, and the hydrothermal reaction time is 20-30 hours.
The examples are intended to illustrate the invention, but not to limit it. The described embodiments may be modified by those skilled in the art without departing from the spirit and scope of the present invention, and therefore, the scope of the appended claims should be accorded the full scope of the invention as set forth in the appended claims.

Claims (21)

1. A graphene oxide cardiovascular stent, characterized in that: the blood-purifying stent comprises a first end part (11) and a second end part (12) which have the same structure, wherein a plurality of support rods (13) are connected between the first end part (11) and the second end part (12), and the first end part (11), the second end part (12) and the plurality of support rods (13) form a stent main body and allow blood to pass through; a rotary grinding bolt assembly (2) is arranged in the support main body, the rotary grinding bolt assembly (2) is provided with a hollow cylindrical rotating main body (20), a plurality of uniformly distributed rotary grinding bulges (22) are arranged on the outer wall of the rotating main body (20), a spiral rib (21) is arranged on the inner wall of the rotating main body (20), and a crushing blade is arranged on the rib (21); wherein, the inner and outer surfaces of the first end part (11), the second end part (12), the support rod (13) and the rotary grinding bolt component (2) are coated with graphene oxide layers.
2. The graphene oxide cardiovascular stent of claim 1, wherein: the rotational grinding bulges (22) are arranged on the outer wall of the rotating main body (20) in rows, and the rotational grinding bulges (22) are of hemispherical structures.
3. The graphene oxide cardiovascular stent of claim 1, wherein: the first end portion (11) comprises an outer ring (111), the inner side of the outer ring (111) is connected with a transition ring (112), the transition ring (112) is connected with an inner ring (113), and the diameter of the inner ring (113) is smaller than that of the outer ring (111).
4. The graphene oxide cardiovascular stent of claim 3, wherein: the number of the supporting rods (13) is six or eight, and two ends of the supporting rods (13) are respectively fixed on the inner rings (113) of the first end part (11) and the second end part (12).
5. The graphene oxide cardiovascular stent of claim 4, wherein: the end of the inner ring (113) is provided with plug holes, the number of the plug holes corresponds to the number of the support rods (13), the support rods (13) are plugged in the plug holes, and the support rods (13) are in interference fit with the plug holes.
6. The graphene oxide cardiovascular stent of claim 1, wherein: the two ends of the support rod (13) close to the first end portion (11) and the second end portion (12) are respectively provided with a limiting rod (131) facing the inside of the support body, and the limiting rods (131) at the two ends limit the moving range of the rotary grinding bolt assembly (2).
7. The graphene oxide cardiovascular stent of claim 1, wherein: the first end part (11), the second end part (12) and the support rod (13) are made of polyethylene terephthalate, nylon, polyethylene, polyurethane or soft polyvinyl chloride.
8. The graphene oxide cardiovascular stent of claim 1, wherein: the first end part (11), the second end part (12) and the support rod (13) are made of silicon resin, synthetic polyisoprene or latex.
9. The graphene oxide cardiovascular stent of claim 1, wherein: the outer wall of the rotating body (20) is also provided with a plurality of radiopaque marking elements which are made of radiopaque materials.
10. The graphene oxide cardiovascular stent of claim 1, wherein: the outer surfaces of the first end (11) and the second end (12) are provided with a textured surface that prevents migration of the stent body, the textured surface extending over a portion of the length and/or circumference of the first end (11) and the second end (12).
11. The graphene oxide cardiovascular stent of claim 10, wherein: the textured surface is a series of bumps or grooves provided on the outer surface of the first end (11) or the second end (12).
12. The graphene oxide cardiovascular stent of claim 10, wherein: the textured surface is formed on the outer surface of the first end portion (11) or the second end portion (12) by scoring, grinding or scratching.
13. The graphene oxide cardiovascular stent of claim 3, wherein: the outer ring (111) of the first end part (11) is provided with a plurality of fixing barbs (3), and the plurality of fixing barbs (3) are uniformly distributed on the outer ring (111).
14. The graphene oxide cardiovascular stent of claim 13, wherein: the outer ring (111) is provided with a sliding groove, the sliding groove comprises a large groove (101) arranged on the inner side of the outer surface (110) of the outer ring (111), and the outer end of the large groove (101) is communicated with the small groove (102).
15. The graphene oxide cardiovascular stent of claim 14, wherein: a telescopic buffer part (4) is arranged in the large groove (101), and the tail end of the telescopic buffer part (4) is connected with a fixed barb (3).
16. The graphene oxide cardiovascular stent of claim 15, wherein: fixed barb (3) including with flexible bolster (4) fixed connection's slider (33), slider (33) slide and set up in big groove (101), fixedly connected with slide bar (32) on slider (33), slide bar (32) slide along microgroove (102), the end-to-end connection of slide bar (32) has stationary dog (31), the outward flange of stationary dog (31) is provided with a plurality of barbs (34).
17. The graphene oxide cardiovascular stent of claim 16, wherein: the fixed claw (31) comprises a horizontal part (311), a first inclined part (312) and a second inclined part (313) which are connected in sequence.
18. The graphene oxide cardiovascular stent of claim 17, wherein: wherein, the horizontal part (311) is fixedly connected with the slide bar (32), the barb (34) is arranged on the outer edge of the second inclined part (313), the inclination angle of the first inclined part (312) is 20-35 degrees, and the inclination angle of the second inclined part is 10-15 degrees.
19. A method for preparing the graphene oxide cardiovascular stent of any one of claims 1 to 18, comprising the following specific steps:
step S1, manufacturing a first end part, a second end part, a supporting rod, a rotary grinding bolt component, an elastic buffer part and a fixing barb;
step S2, coating the graphene oxide layer on the first end part, the second end part, the supporting rod and the rotary grinding bolt assembly;
step S3, assembling the first end portion, the second end portion, the support bar, the rotational grind key assembly, the elastic buffer, and the fixation barbs.
20. The method for preparing a graphene oxide cardiovascular stent according to claim 19, wherein: in step S2, the first end portion, the second end portion, the support rod, and the rotational grinding bolt assembly are placed in the sheet-like graphene nanosheet precursor solution, and the coating conditions are hydrothermal.
21. The method for preparing a graphene oxide cardiovascular stent according to claim 20, wherein: the hydrothermal temperature is 150 ℃ and 200 ℃, and the hydrothermal reaction time is 20-30 hours.
CN201810381592.4A 2018-04-25 2018-04-25 Graphene oxide heart blood vessel stent and preparation method thereof Active CN108578023B (en)

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CN110123499B (en) * 2019-05-28 2021-02-09 青岛大学附属医院 Multifunctional automatic blood vessel support device
CN112618120A (en) * 2020-12-31 2021-04-09 郑州美港高科生物科技有限公司 Completely degradable magnesium alloy cardiovascular stent

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CN107496006A (en) * 2017-09-22 2017-12-22 南京普微森医疗科技有限公司 Take thrombus support

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AU2005208583A1 (en) * 2004-01-20 2005-08-11 Massachusetts General Hospital Permanent thrombus filtering stent
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EP2959853A1 (en) * 2013-02-21 2015-12-30 Microport Neurotech (Shanghai) Co. Ltd. Thrombectomy device and thrombectomy equipment
CN104771203A (en) * 2015-03-11 2015-07-15 上海理工大学 Blood vessel cleaning device
CN107280728A (en) * 2017-08-04 2017-10-24 李莉 A kind of thrombus remover for preventing blood vessel from damaging
CN107496006A (en) * 2017-09-22 2017-12-22 南京普微森医疗科技有限公司 Take thrombus support

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