CN108567946A - A kind of drug granule and preparation method thereof for treating gastritis - Google Patents
A kind of drug granule and preparation method thereof for treating gastritis Download PDFInfo
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- CN108567946A CN108567946A CN201810844709.8A CN201810844709A CN108567946A CN 108567946 A CN108567946 A CN 108567946A CN 201810844709 A CN201810844709 A CN 201810844709A CN 108567946 A CN108567946 A CN 108567946A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Abstract
The invention discloses a kind of drug granule and preparation method thereof for treating gastritis, raw material includes by weight:10 20 parts of honeysuckle stem, 46 parts of shepherdspurse inflorescence, 46 parts of pawpaw, 10 15 parts of fingered citron, 68 parts of folium artemisiae argyi, 15 20 parts of Tupistra, 35 parts of galangal, 12 parts of peppermint, peppermint is uniformly divided into two groups;Include the following steps, S1:Honeysuckle stem after drying, shepherdspurse inflorescence, pawpaw, fingered citron, folium artemisiae argyi, Tupistra, galangal and one group of peppermint after dividing equally are sequentially placed into pulverizer and are crushed, and each raw material after crushing is mixed;S2:Mixed raw material is sent in grinder and is ground into powdery, and is sieved.By the mixing of Chinese medicine, a variety of drugs relieve pain stomach, are stopped blooding, preventing or arresting vomiting dissipate-swelling, play the role for the treatment of and health care;Drug is taken with nutty structure so that its inlet port accent reduces bitterness sense, and particle surface adheres to peppermint, and people can only smell the cooling taste of peppermint when oral, cover the peculiar taste of drug.
Description
Technical field
The present invention relates to a kind of medicine field, the drug granule and preparation method thereof of specifically a kind for the treatment of gastritis.
Background technology
Present rhythm of life is getting faster, and the pressure brought that works constantly increases, in addition present environmental pollution is serious.People
The health of itself ignored, the thing followed is various diseases.These are all to put forward anti-ability to disease because body immunity is reduced
It is weak, it takes advantage of a weak point to these diseases;Wherein gastritis is with regard to a kind of common disease.
Gastritis is stomach lining acute and chronic inflammation caused by a variety of different pathogenies, is often accompanied by epithelial damage, mucosal inflammation
Reaction and epithelium regeneration.Main and diet and living habit have relationship, because to make to open sexual organ, usually eating and drinking without temperance, and mistake
The raw and cold food of food or maror, long-term alcohol, diet do not have rule, eat and drink immoderately, smoke, no rule of working and resting, excessively
Tired these factors of anxiety can result in the generation of gastritis.
Invention content
The purpose of the present invention is to provide a kind of drug granules and preparation method thereof for treating gastritis, to solve above-mentioned background
The problem of being proposed in technology.
To achieve the above object, the present invention provides the following technical solutions:
A kind of drug granule for treating gastritis, raw material include by weight:10-20 parts of honeysuckle stem, 4-6 parts of shepherdspurse inflorescence,
4-6 parts of pawpaw, 10-15 parts of fingered citron, 6-8 parts of folium artemisiae argyi, 15-20 parts of Tupistra, 3-5 parts of galangal, 1-2 parts of peppermint, peppermint is uniform
It is divided into two groups.
A kind of preparation method of drug granule that treating gastritis, includes the following steps:
S1:By the honeysuckle stem after drying, shepherdspurse inflorescence, pawpaw, fingered citron, folium artemisiae argyi, Tupistra, galangal and divide equally after one
Group peppermint, which is sequentially placed into pulverizer, to crush, and each raw material after crushing is mixed;
S2:Mixed raw material is sent in grinder and is ground into powdery, and is sieved;
S3:The drug of powdery is encased in blender, and suitable quantity of water is added, after drug is stirred 10-20 minutes,
Inside is heated, evaporation wherein moisture makes internal to be in paste.
S4:Pasta raw material is poured into extruder, skin drying is carried out after squeezing out graininess;
S5:One group of peppermint of residue is put into milling apparatus after being ground into powdery plus water is stirred, mixed liquor is put into
30 minutes are stood in glassware, the liquid that vessel upper layer 2/3 is extracted with drawing liquid pump is sent in immersion vessel.
S6:The particle for the skin drying processed in S4 is poured into impregnate in vessel and stands 5 minutes liquid is made to enter particle
It is pulled out behind surface, is put into dryer and dries 1h.
S7:Granule packaging after drying is preserved.
Honeysuckle stem:It is sweet in flavor, it trembles with fear, attaches to the lung and stomach meridians, there is the benefits of clearing heat and detoxicating, dredging collateral.Cure mainly warm disease heating, toxic-heat and blood stasis, carbuncle
Swollen sore, beriberoid pyretic arthralgia, redness and swelling of joints heat pain.
Shepherdspurse inflorescence:With cooling blood and hemostasis, the effect of clearing heat and promoting diuresis.Uterine bleeding is cured mainly, hematuria is spitted blood, spitting of blood, bleeding from five sense organs or subcutaneous tissue, children
Breast product, dysentery.
Pawpaw:Edible in fruit puckery, boiling or dipping liquid glucose, being used as medicine has the benefits of relieving the effect of alcohol, remove phlegm, is pleasant, stop dysentery.
Fingered citron:Root, stem, leaf, flower, fruit can be used as medicine, pungent, bitter, sweet, warm, nontoxic;Enter liver, spleen, stomach three to pass through, reasonable gasification
Phlegm, preventing or arresting vomiting dissipate-swelling, liver soothing and speen fortifying and the more kinds of medicinal functions of stomach.
Folium artemisiae argyi:For spitting blood, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, menorrhalgia, blood under threatened abortion, few abdomen crymodynia, through uncomfortable, uterus cold infertile of trembling with fear;
Control pruitus outside.Vinegar Chinese mugwort charcoal warming channel for arresting bleeding, is used for deficient cold type bleeding.
Tupistra:With clearing heat and detoxicating, the effect of dispelling wind and eliminating dampness, removing blood stasis and analgesics.It is usually used in diphtheria, abscess of throat, rheumatism
Numbness pain, traumatic injury, stomachache, carbuncle sore tumefacting virus, poisonous snake, lyssodexis.
Galangal:Warm stomach preventing or arresting vomiting, eliminating cold to stop pain.
Peppermint:Control the diseases such as influenza, headache, hot eyes, body heat, throat, gum swelling and pain.External application can control neuralgia, skin
Skin itch, fash and eczema etc..Usually with peppermint for tea, clear away heart-fire improving eyesight.
Further:The thickness of grainy surface is 0.2-0.5mm in the S4.
Compared with prior art, the beneficial effects of the invention are as follows:
1, by the mixing of Chinese medicine, a variety of drugs relieve pain stomach, are stopped blooding, preventing or arresting vomiting dissipate-swelling, play treatment and health care
Effect, and by processing of crude drugs at particle, drug effect can quickly enter stomach after consumption, and drug effect is mild, convenient for holding
It is treated long.
2, drug is taken with nutty structure so that its inlet port accent reduces bitterness sense, with conventional instant particles as Chinese medicine etc.
It is more comfortable, reduce the taste perception to drug;Particle surface adheres to peppermint, and people can only smell the clear of peppermint when oral
Cool taste covers the peculiar taste of drug, so that people especially children is more easily received drug, and take, improves drug
Edible comfort level.
Specific implementation mode
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of drug granule for treating gastritis, raw material include by weight:10 parts of honeysuckle stem, 4 parts of shepherdspurse inflorescence, pawpaw 4
Part, 10 parts of fingered citron, 6 parts of folium artemisiae argyi, 15 parts of Tupistra, 3 parts of galangal, 1 part of peppermint, peppermint are uniformly divided into two groups, every group 0.5 part.
A kind of preparation method of drug granule that treating gastritis, includes the following steps:
S1:By the honeysuckle stem after drying, shepherdspurse inflorescence, pawpaw, fingered citron, folium artemisiae argyi, Tupistra, galangal and divide equally after one
Group peppermint, which is sequentially placed into pulverizer, to crush, and each raw material after crushing is mixed;
S2:Mixed raw material is sent in grinder and is ground into powdery, and is sieved;
S3:The drug of powdery is encased in blender, and suitable quantity of water is added, after drug is stirred 10-20 minutes,
Inside is heated, evaporation wherein moisture makes internal to be in paste.
S4:Pasta raw material is poured into extruder, skin drying, surface thickness 0.2- are carried out after squeezing out graininess
0.5mm;
S5:One group of peppermint of residue is put into milling apparatus after being ground into powdery plus water is stirred, mixed liquor is put into
30 minutes are stood in glassware, the liquid that vessel upper layer 2/3 is extracted with drawing liquid pump is sent in immersion vessel.
S6:The particle for the skin drying processed in S4 is poured into impregnate in vessel and stands 5 minutes liquid is made to enter particle
It is pulled out behind surface, is put into dryer and dries 1h.
S7:Granule packaging after drying is preserved.
Embodiment 2
A kind of drug granule for treating gastritis, raw material include by weight:16 parts of honeysuckle stem, 5 parts of shepherdspurse inflorescence, pawpaw 5
Part, 13 parts of fingered citron, 7 parts of folium artemisiae argyi, 18 parts of Tupistra, 4 parts of galangal, 1.6 parts of peppermint, peppermint are uniformly divided into two groups, every group 0.8
Part.
A kind of preparation method of drug granule that treating gastritis, includes the following steps:
S1:By the honeysuckle stem after drying, shepherdspurse inflorescence, pawpaw, fingered citron, folium artemisiae argyi, Tupistra, galangal and divide equally after one
Group peppermint, which is sequentially placed into pulverizer, to crush, and each raw material after crushing is mixed;
S2:Mixed raw material is sent in grinder and is ground into powdery, and is sieved;
S3:The drug of powdery is encased in blender, and suitable quantity of water is added, after drug is stirred 10-20 minutes,
Inside is heated, evaporation wherein moisture makes internal to be in paste.
S4:Pasta raw material is poured into extruder, skin drying, surface thickness 0.2- are carried out after squeezing out graininess
0.5mm;
S5:One group of peppermint of residue is put into milling apparatus after being ground into powdery plus water is stirred, mixed liquor is put into
30 minutes are stood in glassware, the liquid that vessel upper layer 2/3 is extracted with drawing liquid pump is sent in immersion vessel.
S6:The particle for the skin drying processed in S4 is poured into impregnate in vessel and stands 5 minutes liquid is made to enter particle
It is pulled out behind surface, is put into dryer and dries 1h.
Embodiment 3
A kind of drug granule for treating gastritis, raw material include by weight:20 parts of honeysuckle stem, 6 parts of shepherdspurse inflorescence, pawpaw 6
Part, 15 parts of fingered citron, 8 parts of folium artemisiae argyi, 20 parts of Tupistra, 5 parts of galangal, 2 parts of peppermint, peppermint are uniformly divided into two groups, every group 1 part.
A kind of preparation method of drug granule that treating gastritis, includes the following steps:
S1:By the honeysuckle stem after drying, shepherdspurse inflorescence, pawpaw, fingered citron, folium artemisiae argyi, Tupistra, galangal and divide equally after one
Group peppermint, which is sequentially placed into pulverizer, to crush, and each raw material after crushing is mixed;
S2:Mixed raw material is sent in grinder and is ground into powdery, and is sieved;
S3:The drug of powdery is encased in blender, and suitable quantity of water is added, after drug is stirred 10-20 minutes,
Inside is heated, evaporation wherein moisture makes internal to be in paste.
S4:Pasta raw material is poured into extruder, skin drying, surface thickness 0.2- are carried out after squeezing out graininess
0.5mm;
S5:One group of peppermint of residue is put into milling apparatus after being ground into powdery plus water is stirred, mixed liquor is put into
30 minutes are stood in glassware, the liquid that vessel upper layer 2/3 is extracted with drawing liquid pump is sent in immersion vessel.
S6:The particle for the skin drying processed in S4 is poured into impregnate in vessel and stands 5 minutes liquid is made to enter particle
It is pulled out behind surface, is put into dryer and dries 1h.
By adhering to one layer of peppermint in particle surface, the mint flavored of particle surface is improved so that people are more taking medicine
It is easy to receive the smell of drug, refrigerant taste more easily children receive, and children is avoided to generate resistance to the smell of drug;And
And peppermint has certain positive effect for the raising of drug effect.According to above-mentioned, to drug after Clinical practice, takes 60 people
Impression is investigated, and is divided according to different crowds, see the table below:
Classification | It is comfortable | Generally | Difference |
The elderly | 14 | 4 | 2 |
Adult | 10 | 6 | 4 |
Children | 16 | 3 | 1 |
Case 1:Zhang, man 31 years old, with glutted, abdominal pain after Nausea and vomiting, food, suffer from gastritis, clothes after diagnosing
After particle of the present invention, 4 tablets each time (0.5g/), 3 times a day, 10 are even served, pain relief, symptoms of emesis disappears, recovery from illness.
Case 2:Journey, female, for many years with stomachache, when stomachache are difficult to endure, and the stomach medicine eaten only postpones pain, Er Qie great
With a bloodstain when just, pain is slowed down by anodyne when having a stomachache serious;After taking particle of the present invention, (0.5g/ 5 tablets each time
Grain), third day, pain slows down, and need not take antalgica, and without bloodstain when defecation, by the tenth day, physical recovery was normal;Subtract
Few dosage is fully recovered after taking January, and drug withdrawal was taken in March, was remained dormant, and the mint flavored in drug feels happy,
Enteron aisle is unobstructed etc..
1, by the mixing of Chinese medicine, a variety of drugs relieve pain stomach, are stopped blooding, preventing or arresting vomiting dissipate-swelling, play treatment and health care
Effect, and by processing of crude drugs at particle, drug effect can quickly enter stomach after consumption, and drug effect is mild, convenient for holding
It is treated long.
2, drug is taken with nutty structure so that its inlet port accent reduces bitterness sense, with conventional instant particles as Chinese medicine etc.
It is more comfortable, reduce the taste perception to drug;Particle surface adheres to peppermint, and people can only smell the clear of peppermint when oral
Cool taste covers the peculiar taste of drug, so that people especially children is more easily received drug, and take, improves drug
Edible comfort level.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiment being appreciated that.
Claims (3)
1. a kind of drug granule for treating gastritis, which is characterized in that its raw material includes by weight:10-20 parts of honeysuckle stem, shepherd's purse
4-6 parts of flower, 4-6 parts of pawpaw, 10-15 parts of fingered citron, 6-8 parts of folium artemisiae argyi, 15-20 parts of Tupistra, 3-5 parts of galangal, 1-2 parts of peppermint,
Peppermint is uniformly divided into two groups.
2. a kind of a kind of preparation method of drug granule that treating gastritis as described in claim 1, which is characterized in that including with
Lower step:
S1:By the honeysuckle stem after drying, shepherdspurse inflorescence, pawpaw, fingered citron, folium artemisiae argyi, Tupistra, galangal and divide equally after it is one group thin
Lotus is sequentially placed into pulverizer and crushes, and each raw material after crushing is mixed;
S2:Mixed raw material is sent in grinder and is ground into powdery, and is sieved;
S3:The drug of powdery is encased in blender, and suitable quantity of water is added, after drug is stirred 10-20 minutes, internally
Portion is heated, and evaporation wherein moisture makes internal to be in paste;
S4:Pasta raw material is poured into extruder, skin drying is carried out after squeezing out graininess;
S5:One group of peppermint of residue is put into milling apparatus after being ground into powdery plus water is stirred, mixed liquor is put into glass
30 minutes are stood in vessel, the liquid that vessel upper layer 2/3 is extracted with drawing liquid pump is sent in immersion vessel;
S6:The particle for the skin drying processed in S4 is poured into impregnate to stand in vessel and is pulled out after five minutes, is put into dryer and dries
Dry 1h;
S7:Granule packaging after drying is preserved.
3. a kind of preparation method of drug granule for treating gastritis according to strong demand 2, which is characterized in that in the S4
The thickness of grainy surface is 0.2-0.5mm.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1079664A (en) * | 1993-05-25 | 1993-12-22 | 辛旺耀 | A kind of Chinese patent medicine for the treatment of Peptic Ulcers and atrophic gastritis |
CN103536881A (en) * | 2013-10-09 | 2014-01-29 | 董成祥 | Drug for treating chronic gastritis |
CN106983823A (en) * | 2017-06-07 | 2017-07-28 | 湖南云从科技有限公司 | It is a kind of to treat pharmaceutical formulation of rhinitis and preparation method thereof |
-
2018
- 2018-07-27 CN CN201810844709.8A patent/CN108567946A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1079664A (en) * | 1993-05-25 | 1993-12-22 | 辛旺耀 | A kind of Chinese patent medicine for the treatment of Peptic Ulcers and atrophic gastritis |
CN103536881A (en) * | 2013-10-09 | 2014-01-29 | 董成祥 | Drug for treating chronic gastritis |
CN106983823A (en) * | 2017-06-07 | 2017-07-28 | 湖南云从科技有限公司 | It is a kind of to treat pharmaceutical formulation of rhinitis and preparation method thereof |
Non-Patent Citations (1)
Title |
---|
史彦章等: "平萎汤治疗慢性萎缩性胃炎52例疗效观察", 《河北中医》 * |
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Application publication date: 20180925 |