CN108553645A - A kind of innovative auxiliary material sucrose and preparation method thereof - Google Patents
A kind of innovative auxiliary material sucrose and preparation method thereof Download PDFInfo
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- CN108553645A CN108553645A CN201810255724.9A CN201810255724A CN108553645A CN 108553645 A CN108553645 A CN 108553645A CN 201810255724 A CN201810255724 A CN 201810255724A CN 108553645 A CN108553645 A CN 108553645A
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- sucrose
- microns
- auxiliary material
- whole grain
- dry granulating
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 title claims abstract description 81
- 229930006000 Sucrose Natural products 0.000 title claims abstract description 78
- 239000005720 sucrose Substances 0.000 title claims abstract description 75
- 239000000463 material Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title abstract description 12
- 235000020985 whole grains Nutrition 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 22
- 235000000346 sugar Nutrition 0.000 claims description 14
- 235000003599 food sweetener Nutrition 0.000 claims description 12
- 239000003765 sweetening agent Substances 0.000 claims description 12
- 235000013339 cereals Nutrition 0.000 claims description 11
- 239000002245 particle Substances 0.000 claims description 10
- 238000009434 installation Methods 0.000 claims description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- 239000008103 glucose Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N D-Maltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 2
- 108010011485 Aspartame Proteins 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 2
- 229930091371 Fructose Natural products 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
- 239000004378 Glycyrrhizin Substances 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 2
- 239000000605 aspartame Substances 0.000 claims description 2
- 235000010357 aspartame Nutrition 0.000 claims description 2
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 2
- 229960003438 aspartame Drugs 0.000 claims description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 claims description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 2
- 235000019410 glycyrrhizin Nutrition 0.000 claims description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 2
- 235000012907 honey Nutrition 0.000 claims description 2
- 239000000845 maltitol Substances 0.000 claims description 2
- 235000010449 maltitol Nutrition 0.000 claims description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 2
- 229940035436 maltitol Drugs 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 229940085605 saccharin sodium Drugs 0.000 claims description 2
- 229940013618 stevioside Drugs 0.000 claims description 2
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 2
- 235000019202 steviosides Nutrition 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 239000004376 Sucralose Substances 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 1
- 235000019408 sucralose Nutrition 0.000 claims 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 16
- 235000013305 food Nutrition 0.000 abstract description 10
- 239000003814 drug Substances 0.000 abstract description 7
- 229940079593 drug Drugs 0.000 abstract description 6
- 238000005516 engineering process Methods 0.000 abstract description 6
- 238000003860 storage Methods 0.000 abstract description 3
- 229960004793 sucrose Drugs 0.000 description 64
- 239000008187 granular material Substances 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000013078 crystal Substances 0.000 description 4
- 230000007547 defect Effects 0.000 description 4
- 238000005265 energy consumption Methods 0.000 description 4
- 238000002425 crystallisation Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 150000003445 sucroses Chemical class 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 241001282153 Scopelogadus mizolepis Species 0.000 description 1
- 235000010358 acesulfame potassium Nutrition 0.000 description 1
- 229960004998 acesulfame potassium Drugs 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention relates to a kind of innovative auxiliary material sucrose and preparation method thereof, belong to drug and food technology field.The innovative auxiliary material sucrose is fine particulate, and grain size is 425 microns to 850 microns, and moisture is less than 0.5%, and bulk density is 0.55 0.78g/ml, and angle of repose is less than 30 degree.The innovative auxiliary material sucrose can be set extensively and according to actual requirement with compressibility, good mobility, purity range, moisture very little, easily storage, transport, production process are environmentally safe, the characteristics of all the components are all water-soluble, and instant food, health products and pharmaceutical production use.
Description
Technical field
The present invention relates to a kind of innovative medicinal or food auxiliary material more particularly to a kind of innovative auxiliary material sucrose and its systems
Preparation Method belongs to drug and food technology field.
Background technology
Sucrose is widely applied as important sweetener and energy source in production fields such as food, health products, drugs.
However industrial production sucrose generally uses crystallisation, crystallization of sucrose particle is larger, while compressibility is excessively poor, is unfavorable for suppressing
Piece agent, therefore be difficult to directly apply to the productions such as drug tablet, food tablet, troche of health products；Even if sucrose is crushed, because
Its mobility it is very poor and meanwhile it is easy to moisture absorption caking it is not easy to maintain, be not easy to be applied to direct tablet compressing produce.And pass through physical modification
Compressibility sucrose granules can overcome difficulty of the sucrose in tabletting application, while remain the intrinsic sugariness of sucrose and natural
Flavor, therefore compressibility sucrose granules are good auxiliary materials, can preferably be applied in the productions such as food, health products, drug.
In consideration of it, having carried out correlative study to compressibility sucrose both at home and abroad.
External at present to have following sompressible sugar product, brand and production technology are：(1) Di-Pac is contained by concentration
Physiology is subjected to the sucrose solution of additive to produce, including the techniques mistake such as mechanical agitation over-saturation sucrose solution and curing operation
Journey, principle are that the crystal in solution is agglomerated into paste and cures each other, are a kind of to be produced using the agllutination principle of crystal.
(2) Nutab is produced by being compacted cane sugar powder, conversion sugar and starch.(3) Alveosucre is with wet cane sugar powder and malt
Dextrin is obtained by being granulated.
In addition, also have much patent documents about compressible sugar particle, such as：
CN1520463A is the method for dry sucrose solution, the product obtained in this way and purposes.This method is related to a kind of system
The method of standby sompressible sugar solution, including the drying steps of the initial sucrose solution atomization of at least one antigraining agent are added,
In the cane sugar content of initial sucrose solution be less than saturation capacity, and its amount of dry matter is preferably about the pact of composition total weight
60wt%.This method needs to use multi-stage spray drying equipment, there is that equipment investment is big, and sucrose solution concentration is low, big equal lack of consuming energy
Point.
CN1884584A discloses a kind of production method of granular compressible sugar, and this method will contain antigraining agent
Overheat, supersaturated sucrose liquid and powdery sompressible sugar kind are stirred, and are crushed and screened after vacuum dried, obtaining graininess can
Compress sugar product.The shortcomings of this method is method for crystallising, and material hardness is big after low, vacuum drying that there are yields, hardly possible crushes.
CN103820583A discloses a kind of preparation method of graininess compressible sucrose, and this method is by antigraining agent
The supersaturated sucrose liquid of overheat and powdery sompressible sugar crystal seed be stirred it is vacuum dried after pelletized using high-speed mixing granulating machine,
Forced air drying is sieved again, obtains granular compressible sugar product.There are the disadvantages such as complex process, yield be low for this method.It is carrying simultaneously
While high-compressibility, mobility, the reunion performance of particle but also be greatly affected.
CN 1884584A disclose a kind of method producing sompressible sugar.This method uses crystallisation, and it is brilliant will to contain resistive connection
The overheating of agent, supersaturated sucrose solution and powdery sompressible sugar crystal seed are stirred, and are crushed and screened after vacuum dried, are obtained
Granular sompressible sugar product.Due in the method material experience cmpletely be dried in vacuo after crush, deposit after vacuum drying
Material hardness itself is larger, and crushing operation is difficult, the lower defect of compressibility sugar yield of desired particle size.
CN105833280A discloses a kind of preparation method of compressible sucrose.This method resists using sucrose as primary raw material
Compressible sucrose particle is made using bed spray as auxiliary material in crystallizing agent and talcum powder.Since this method uses fluid bed
Sucrose granules are prepared, since spray solution introduces a large amount of moisture, progress must be taken a significant amount of time after particle is made
Drying just the loss on drying of product can be made to reach suitable, therefore it is long there are the operating time, energy consumption is larger, cost increase, exist
The defects of insoluble composition.
In short, production compressibility sucrose granules there are equipment investments big, high energy consumption, operating time be long at present, in product
The problem of containing insoluble auxiliary material.It is industrial be badly in need of finding out a kind of production equipment be easy to get, small investment, it is simple to operation, do not add not
The higher compressibility sucrose granules of soluble auxiliary materials, sucrose purity and its production technology.
Invention content
Problem to be solved by this invention is to overcome the defect of existing production technology, that is, overcomes in existing preparation process and need
It invests big scale production equipment, high energy consumption and environment is caused centainly to pollute, overcome and need that sucrose is dissolved and drawn in preparation process
The defects of entering other substances such as antigraining agent etc. and causing product purity limited, provides a kind of innovative auxiliary material sucrose, the innovation
Type auxiliary material sucrose can be set extensively and according to actual requirement with compressibility, good mobility, purity range, and moisture is very
Small, easily storage, transport, production process is environmentally safe, and all the components are all water-soluble, instant food, health products and medicine
The characteristics of product produce and use, remains the natural flavour mountaineous of sucrose and improves chewiness.In addition, the present invention further provides its systems
Preparation Method.
Technical problem of the present invention has following technical scheme realization.
A kind of innovative auxiliary material sucrose, the innovative auxiliary material sucrose are fine particulate, and grain size is 425 microns to 850 micro-
Rice, moisture are less than 0.5%, and bulk density 0.55-0.78g/ml, angle of repose is less than 30 degree.
A method of above-mentioned innovative auxiliary material sucrose is prepared, is included the following steps：
1, sucrose is crushed to all through 80 mesh sieve (being less than 180 microns)；
2, the sucrose for finishing pulverization process is added in dry granulating machine；
3, dry granulating machine pressure roller operating pressure is adjusted to 80-100bar, roller gap 0.6-1.2mm, pressure roller turns
Speed is 8-15rpm, runs machine, suppresses sheet；
4, installation whole grain mesh size is 0.7-1.0mm, is 100-200rpm with whole grain cutter rotating velocity, will be obtained above
Sheet carries out whole grain；
5, the product after whole grain is sieved, filters out the product of 425 microns to 850 microns of grain size, remaining particle
Or powder returns to dry granulating machine and continues to pelletize.
The prior art is all made of wet granulation, and the present invention is groped by technique against its thinking, had surprisingly found that, using spy
It is 425 microns to 850 microns in grain size to determine preparation process by sucrose granules control, and moisture is less than 0.5%, bulk density 0.55-
0.78g/ml when angle of repose is less than 30 degree, has good compressibility, mobility, does not reunite, do not lump, and purity is high
(sucrose need not be dissolved and introduce antigraining agent), to obtain technical solution of the present invention.The innovative auxiliary material sucrose has
Compressibility, good mobility, purity range are extensive and can be set according to actual requirement, moisture very little, easily storage, fortune
Defeated, production process is environmentally safe, and all the components are all water-soluble, what instant food, health products and pharmaceutical production used
Feature remains the natural flavour mountaineous of sucrose and improves chewiness.The ingredient of innovative auxiliary material sucrose of the present invention can be complete
Portion is dissolved in water, be particularly suitable for requirement must not the drug containing insoluble matter or food, health products production.Wound of the present invention
The preparation method of novel auxiliary material sucrose simplifies processing step compared with the prior art, reduces material variety, is only applicable in conventional
Equipment, therefore, at low cost, low energy consumption, pollution-free.
Further, innovative auxiliary material sucrose of the present invention can contain other suitable sweeteners, i.e.,：In prescription
The mass ratio of contained sucrose can adjust between 80%-100%, and the mass ratio of other sweeteners can be 0%-
20%.Other sweeteners are selected from the natural sugars such as glucose, fructose, maltose, starch sugar, lactose, can also include wood
Sugar alcohol, D-sorbite, maltitol, mannitol, antierythrite, saccharin sodium, honey element, acesulfame potassium, Aspartame, trichlorine sugarcane
Sugar, Stevioside, glycyrrhizin etc. be natural or artificial synthesis edulcorant.
When containing other sweeteners, preparation method is as follows：
1, sucrose is crushed to all by 80 mesh sieve (being less than 180 microns), other sweeteners, which also crush, passes through 80 mesh
Sieve；
2, sucrose is uniformly mixed with other sweeteners；
3, it feeds the mixture into dry granulating machine；
4, dry granulating machine pressure roller operating pressure is adjusted to 80-100bar, roller gap 0.6-1.2mm, pressure roller turns
Speed is 8-15rpm, runs machine, suppresses sheet；
5, installation whole grain mesh size is 0.7-1.0mm, is that 100-200rpm will be obtained above with whole grain cutter rotating velocity
Sheet carries out whole grain；
6, the product after whole grain is sieved, filters out the product of 425 microns to 850 microns of grain size, remaining particle
Or powder returns to dry granulating machine and continues to pelletize.
Specific implementation mode
By following specific examples, it can more specifically illustrate the present invention, but the present invention is not limited to following implementation
Example.
Embodiment 1
Prescription：Sucrose 1000g
1, the sucrose of recipe quantity is crushed, crosses 80 mesh sieve, is added in dry granulating machine；
2, dry granulating machine pressure roller operating pressure is adjusted to 80bar, roller gap 0.6mm, pressure roller rotating speed is 8rpm.
Machine is run, sheet, thickness about 0.8mm are suppressed；
3, installation whole grain mesh size is 0.7mm, is that 200rpm carries out sheet obtained above with whole grain cutter rotating velocity
Whole grain；
4, the sucrose granules that grain size needed for client is 425 microns to 850 microns are screened out, the compressibility of the present invention is obtained
Sucrose fine grained；
Embodiment 2
Prescription：Sucrose 900g, lactose 100g.
1, the sucrose of recipe quantity is crushed, crosses 80 mesh sieve with lactose, is uniformly mixed, is added in dry granulating machine；
2, dry granulating machine pressure roller operating pressure is adjusted to 90bar, roller gap 0.9mm, pressure roller rotating speed is
12rpm runs machine, suppresses sheet, thickness about 1.1mm；
3, installation whole grain mesh size is 0.7mm, is that 150rpm carries out sheet obtained above with whole grain cutter rotating velocity
Whole grain；
4, the sucrose granules that grain size needed for client is 425 microns to 850 microns are screened out, the compressibility of the present invention is obtained
Sucrose fine grained.
Embodiment 3
Prescription：Sucrose 800g, glucose 200g.
1, the sucrose of recipe quantity is crushed, crosses 80 mesh sieve with glucose, is uniformly mixed, is added in dry granulating machine；
2, dry granulating machine pressure roller operating pressure is adjusted to 100bar, roller gap 1.2mm, pressure roller rotating speed is
15rpm.Machine is run, sheet, thickness about 1.3mm are suppressed；
3, installation whole grain mesh size is 1.0mm, is that 100rpm carries out sheet obtained above with whole grain cutter rotating velocity
Whole grain；
4, the sucrose granules that grain size needed for client is 425 microns to 850 microns are screened out, the compressibility of the present invention is obtained
Sucrose fine grained.
Embodiment 4
Prescription：Sucrose 950g, glucose 50g.
1, the sucrose of recipe quantity is crushed, crosses 80 mesh sieve with glucose, is uniformly mixed, is added in dry granulating machine；
2, dry granulating machine pressure roller operating pressure is adjusted to 90bar, roller gap 1.0mm, pressure roller rotating speed is
10rpm runs machine, suppresses sheet, thickness about 1.2mm；
3, installation whole grain mesh size is 1.0mm, is that 100rpm carries out sheet obtained above with whole grain cutter rotating velocity
Whole grain；
4, the sucrose granules that grain size needed for client is 425 microns to 850 microns are screened out, the compressibility of the present invention is obtained
Sucrose fine grained.
Its angle of repose, compressibility karr coefficient, moisture, group are measured respectively to the sucrose fine grained of above-described embodiment 1 to 4
The performance indicators such as poly- property, and placed 1 month under room temperature, 45% relative humidity and see whether caking easy to moisture absorption, as a result it see the table below：
| Performance | Angle of repose (degree) | Karr coefficient (%) | Moisture (%) | Bulk density (g/ml) | Agglomeration | Hygroscopicity |
| Embodiment 1 | 25.5 | 27.2 | 0.33 | 0.71 | Do not reunite | It does not lump |
| Embodiment 2 | 24.0 | 25.6 | 0.42 | 0.65 | Do not reunite | It does not lump |
| Embodiment 3 | 23.3 | 25.8 | 0.38 | 0.62 | Do not reunite | It does not lump |
| Embodiment 4 | 23.6 | 25.9 | 0.41 | 0.58 | Do not reunite | It does not lump |
The explanation of above example is only intended to help understand the present invention, enable professional and technical personnel in the field realize or
Using the present invention, be not intended to limit the invention, all within the spirits and principles of the present invention, made by any modification, equivalent
Replace, improve etc., it should all be included in the protection scope of the present invention.
Claims (5)
1. a kind of innovative auxiliary material sucrose, which is fine particulate, and grain size is 425 microns to 850 microns,
Moisture is less than 0.5%, and bulk density 0.55-0.78g/ml, angle of repose is less than 30 degree.
2. a kind of method preparing innovative auxiliary material sucrose described in claim 1, which is characterized in that include the following steps：
(1) sucrose is crushed to and is all sieved by 80 mesh, that is, be less than 180 microns；
(2) sucrose for finishing pulverization process is added in dry granulating machine；
(3) dry granulating machine pressure roller operating pressure is adjusted to 80-100bar, roller gap 0.6-1.2mm, pressure roller rotating speed is
8-15rpm runs machine, suppresses sheet；
(4) installation whole grain mesh size is 0.7-1.0mm, is 100-200rpm with whole grain cutter rotating velocity, will be obtained above big
Piece carries out whole grain；
(5) product after whole grain is sieved, filters out the product of 425 microns to 850 microns of grain size, remaining particle or powder
End returns to dry granulating machine and continues to pelletize.
3. innovative auxiliary material sucrose according to claim 1, which is characterized in that it contains sweetener, wherein the matter of sucrose
Amount ratio is 80%-100%, and the mass ratio of sweetener is 0%-20%.
4. innovative auxiliary material sucrose according to claim 3, which is characterized in that sweetener is selected from glucose, fructose, malt
Sugar, starch sugar, lactose, xylitol, D-sorbite, maltitol, mannitol, antierythrite, saccharin sodium, honey element, An Sai
Honey, Aspartame, Sucralose, Stevioside or glycyrrhizin.
5. a kind of method preparing innovative auxiliary material sucrose described in claim 3, which is characterized in that include the following steps：
(1) sucrose is crushed to and is all sieved by 80 mesh, sweetener is crushed to be sieved by 80 mesh, that is, is less than 180 microns；
(2) sucrose is uniformly mixed with sweetener；
(3) it feeds the mixture into dry granulating machine；
(4) dry granulating machine pressure roller operating pressure is adjusted to 80-100bar, roller gap 0.6-1.2mm, pressure roller rotating speed is
8-15rpm runs machine, suppresses sheet；
(5) installation whole grain mesh size is 0.7-1.0mm, is 100-200rpm by sheet obtained above with whole grain cutter rotating velocity
Carry out whole grain；
(6) product after whole grain is sieved, filters out the product of 425 microns to 850 microns of grain size, remaining particle or powder
End returns to dry granulating machine and continues to pelletize.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105148280A (en) * | 2015-07-07 | 2015-12-16 | 深圳国源国药有限公司 | Innovative drug excipient compressible sucrose and preparation method thereof |
| CN110578020A (en) * | 2019-09-24 | 2019-12-17 | 广西南宁万宇科技有限公司 | Method for preparing compressible sucrose from sucrose syrup |
| CN110585437A (en) * | 2018-06-13 | 2019-12-20 | 南京紫鸿生物科技有限公司 | Sugar fine particles and preparation method, equipment and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000066171A1 (en) * | 1999-04-28 | 2000-11-09 | Freund Industrial Co., Ltd. | Sugar alcohol granule aggregate and method for preparing the same |
| CN1358703A (en) * | 2000-03-29 | 2002-07-17 | 罗凯脱兄弟公司 | Powder shape mannitol and process for preparing same |
| CN101744793A (en) * | 2008-12-18 | 2010-06-23 | 山东福田药业有限公司 | Preparation process of DC-level xylitol by using wet-process granulation |
| CN101772304A (en) * | 2007-07-31 | 2010-07-07 | 卡吉尔公司 | Direct compressible dextrose |
| CN103820583A (en) * | 2014-03-06 | 2014-05-28 | 济南百诺医药科技开发有限公司 | Preparation method for granulose condensable sugar |
-
2018
- 2018-03-27 CN CN201810255724.9A patent/CN108553645A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000066171A1 (en) * | 1999-04-28 | 2000-11-09 | Freund Industrial Co., Ltd. | Sugar alcohol granule aggregate and method for preparing the same |
| CN1358703A (en) * | 2000-03-29 | 2002-07-17 | 罗凯脱兄弟公司 | Powder shape mannitol and process for preparing same |
| CN101772304A (en) * | 2007-07-31 | 2010-07-07 | 卡吉尔公司 | Direct compressible dextrose |
| CN101744793A (en) * | 2008-12-18 | 2010-06-23 | 山东福田药业有限公司 | Preparation process of DC-level xylitol by using wet-process granulation |
| CN103820583A (en) * | 2014-03-06 | 2014-05-28 | 济南百诺医药科技开发有限公司 | Preparation method for granulose condensable sugar |
Non-Patent Citations (3)
| Title |
|---|
| 刘文阁 等: "《食糖糖果商品知识》", 30 August 1981 * |
| 孟胜男 等: "《药剂学 在线学习版》", 31 January 2016 * |
| 马勇 等: "《成人高等教育基础医学教材 医用化学 第2版》", 31 January 2017 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105148280A (en) * | 2015-07-07 | 2015-12-16 | 深圳国源国药有限公司 | Innovative drug excipient compressible sucrose and preparation method thereof |
| CN110585437A (en) * | 2018-06-13 | 2019-12-20 | 南京紫鸿生物科技有限公司 | Sugar fine particles and preparation method, equipment and application thereof |
| CN110578020A (en) * | 2019-09-24 | 2019-12-17 | 广西南宁万宇科技有限公司 | Method for preparing compressible sucrose from sucrose syrup |
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Application publication date: 20180921 |