CN108543051A - A kind of natural ginger oil composition hydrogel patch and preparation method thereof - Google Patents
A kind of natural ginger oil composition hydrogel patch and preparation method thereof Download PDFInfo
- Publication number
- CN108543051A CN108543051A CN201810802693.4A CN201810802693A CN108543051A CN 108543051 A CN108543051 A CN 108543051A CN 201810802693 A CN201810802693 A CN 201810802693A CN 108543051 A CN108543051 A CN 108543051A
- Authority
- CN
- China
- Prior art keywords
- parts
- ginger oil
- oil
- composition
- ginger
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of natural ginger oil composition hydrogel patches; including back sheet, drug matrices layer and protective layer; the drug matrices layer by containing ginger oil composition and hydrogel matrix be made, the composition containing ginger oil is made of the raw material of following parts by weight：5 50 parts of ginger oil, 3 30 parts of P-Cymene, 3 30 parts of nutmeg essential oil, 2 20 parts of Peppermint essential oil, 1 10 parts of borneol essential oil；The hydrogel matrix is prepared from the following raw materials in parts by weight：40 60 parts of water, 24 40 parts of moisturizer, 9 18 parts of adhesive, 13 parts of penetrating agent, 13 parts of filler；The invention also discloses the preparation methods of the natural ginger oil composition hydrogel patch.Natural ginger oil composition hydrogel patch prepared by the present invention is non-stimulated and sensitization, and water content is high, the moisturizing phase is long, osmotic effect is good, can be effectively prevented and treated it is dizzy spit, function of spleen and stomach regulating, strengthening vital QI to eliminate pathogenic factors, replenishing the vital essence and removing heat, and environmental protection, safety.
Description
Technical field
The invention belongs to Chinese herbs paste technical fields, and in particular to a kind of natural ginger oil composition hydrogel patch and its system
Preparation Method.
Background technology
Ginger（Zingiber officinal Rosc）Alias ginger, rhizoma zingiberis, Bai Jiang, equal ginger belong to Zingiber
（Zingiberaceae）Zingiber herbaceos perennial is distributed mainly on the west and south to southeast region in China.Group points of Jiang
It is more and complicated, there is unique fragrance flavor and pungent mouthfeel, this unique organoleptic quality be mainly derived from two classes effectively at
Point：Volatile ginger essential oil and do not have volatile gingerol.Ginger essential oil provides unique fragrant flavor for ginger；Gingerol is
Ginger provides unique pungent mouthfeel.
For the ginger of different sources because of growing environment difference, pharmacological property and effect also have different.The study found that ginger has solely
Special medicinal and edible value, motherland's traditional medicine think that ginger is good merchantable brand in medicine, cure mainly anemofrigid cold, breath with cough, vomit, phlegm
Drink, turgor, diarrhea etc..Its first recorded in《Sheng Nong's herbal classic》, acrid flavour, property heat, returns spleen, stomach, kidney, the heart, lung channel are dissipated with middle benefit gas
It is cold, recover Yang and smooth venation, eliminating dampness dissolving phlegm and other effects.It is anti-oxidant, anti-inflammatory, anti-that modern pharmacology research shows that ginger and rhizoma zingiberis all have
Bacterium, anti-gastrointestinal tract bleeding, gastric mucosal protection, improves the multiple pharmacological effects such as local blood circulation at antitumor, antiulcer.
For a long time, about ginger the effect of and application are widely studied always, but the extract of ginger is applied to patch,
Especially the extract of ginger is combined with other drugs, play town of refreshing oneself spit, the patch of strengthening vital QI to eliminate pathogenic factors effect, do not report also
It crosses.
Invention content
Based on the deficiencies of the prior art, the object of the present invention is to provide a kind of natural ginger oil composition hydrogel plasters
Agent, by the composition containing ginger oil reach town of refreshing oneself spit, strengthening vital QI to eliminate pathogenic factors effect, and easy to use, good absorption effect.
The invention also discloses the preparation methods of above-mentioned natural ginger oil composition hydrogel patch.
To achieve the goals above, the technical solution adopted by the present invention is：
A kind of natural ginger oil composition hydrogel patch, including back sheet, drug matrices layer and protective layer, the drug matrices layer
By containing ginger oil composition and hydrogel matrix be made, and the quality of the composition containing ginger oil be hydrogel matrix quality 0.05
~5%；
The composition containing ginger oil is made of the raw material of following parts by weight：5-50 parts of ginger oil, 3-30 parts of P-Cymene, Pork and beans
Cool essential oil 3-30 parts, 2-20 parts of Peppermint essential oil, 1-10 parts of borneol essential oil；
The hydrogel matrix is prepared from the following raw materials in parts by weight：40-60 parts of water, 24-40 parts of moisturizer, adhesive 9-18
Part, 1-3 parts of penetrating agent, 1-3 parts of filler.
Preferably, the moisturizer is formed by propylene glycol and glycerine according to 3-5: 3-5 mixing of mass ratio, described adhesive
It is formed according to 2.5-5: 1-2: 1-2 mixing of mass ratio by Sodium Polyacrylate, polyvinylpyrrolidone and sodium carboxymethylcellulose, institute
It is azone to state penetrating agent, and the filler is superfine silica gel powder.
Preferably, the hydrogel matrix is prepared from the following raw materials in parts by weight：50 parts of deionized water, propylene glycol 15
Part, 15 parts of glycerine, 8 parts of Sodium Polyacrylate, 3 parts of polyvinylpyrrolidone, 3 parts of sodium carboxymethylcellulose, 2 parts of azone, micro mist
1 part of silica gel.
Preferably, in drug matrices layer, the quality of the composition containing ginger oil is the 1-3% of hydrogel matrix quality.
Preferably, the composition containing ginger oil is prepared from the following raw materials in parts by weight：40 parts of ginger oil, P-Cymene 20
Part, 20 parts of nutmeg essential oil, 15 parts of Peppermint essential oil, 5 parts of borneol essential oil.
Preferably, the back sheet is non-woven fabrics, and the protective layer is the paper or polyester film by release treatment.
The preparation method of above-mentioned natural ginger oil composition hydrogel patch, includes the following steps：
（1）Each raw material of the composition containing ginger oil is weighed according to parts by weight, is uniformly mixed, is obtained the composition containing ginger oil；
Each raw material that hydrogel matrix is weighed according to parts by weight, moisturizer and penetrating agent are uniformly mixed, and obtain I phases, will be glued
Mixture and filler are dispersed in water successively, obtain II phases；
（2）According to the mass ratio of composition and hydrogel matrix containing ginger oil, step is weighed（1）The combination containing ginger oil of gained
Object, I phases and II phases；Composition containing ginger oil is scattered in I phases, adds into II phases, is stirred evenly in 40-50 DEG C；
（3）By step（2）After products therefrom is coated on by way of being coated with or spraying on back sheet, repaves and covers protective layer,
In curing in vacuum drying chamber；
（4）Sterilizing, be sliced to get.
Preferably, ginger oil, P-Cymene, nutmeg essential oil, Peppermint essential oil, borneol essence in the composition containing ginger oil
Oil is not using ginger, folium artemisiae argyi, nutmeg fruit, dried peppermint leaf, borneol spiceleaf as raw material, using subcritical abstraction or supercritical extract side
Method is extracted and is obtained；
The specific operation process of the subcritical abstraction method is：Raw material is ground into powdery, in 30-45 DEG C, is extracted using butane
Obtain extract liquor 1-3 times, each 35-45 min, extracting pressure 0.3-0.6 MPa, then by extract liquor recycling butane to get；
The specific operation process of the supercritical extraction is：Raw material is ground into powdery, in 30-55 DEG C, using supercritical CO2
Fluid extraction 1-3 times, each 35-45 min, extracting pressure 6-30 MPa, collect extract to get.
Preferably, the vacuum drying chamber temperature is 40-50 DEG C, and when solidification is 10-15 hours a length of.
The natural ginger oil composition hydrogel patch is preparing the application prevented in remission form pharmaceutical products：For delaying
Solution is carsick, refresh the mind or alleviates arthralgia；The specification of the natural ginger oil composition hydrogel patch is set as 6 × 6
Cm, 3 × 3 cm or 7 × 9 cm, in every patch, the content of the composition containing ginger oil is 0.8-2.4 mg/cm2；Wherein, it is used for
When alleviating carsick, patch specification is 6 × 6 cm, should be pasted at navel in advance before by bus；When for refreshing the mind, patch rule
Lattice are 3 × 3 cm, are pasted at temple；When for alleviating arthralgia, patch specification is 7 × 9 cm, is pasted on pain pass
At section, often patch uses 6 ~ 10 hours, and a patch was applied every 12 hours.
In composition of the present invention containing ginger oil, ginger oil is reused, its warming spleen and stomach for dispelling cold, recover Yang and smooth venation, eliminating dampness dissolving phlegm, cooling is taken to carry
Siddhi is imitated；Using P-Cymene, takes its antibacterial, antiviral, antiasthmatic effect, eliminating the phlegm, enhances the effect of immune function；Using Pork and beans
Cool essential oil takes its tranquilizing soporific, expelling wind and clearing away cold, invigorating the spleen to stop empty effect；Using Peppermint essential oil, its relieveing pain and refreshing is taken, releives and breathes out
The effect of shield；Using borneol essential oil, its inducing resuscitation of having one's ideas straightened out, heat-clearing dissipates poison, removing nebula effect are taken.The medicament selection of the present invention
Ginger, folium artemisiae argyi, nutmeg, peppermint, kapur essential oil be combined, so that each efficacy of drugs is played synergistic effect, so as to have
Effect prevention and treatment are dizzy to spit, function of spleen and stomach regulating, strengthening vital QI to eliminate pathogenic factors, replenishing the vital essence and removing heat.
It is main component that hydrogel matrix used in the present invention, which selects hydrophilic matrix, compatible with Shui Rongxing, fat-soluble medicine
Property is good, and matrix drugloading rate is big；Secondly as the characteristics of hydrogel matrix aqueous formulation, and good permeability, on the skin without residual
It stays, to skin zero damage, thus it is comfortable with using, it is light, the advantages that being noticed after use without pain；In addition, drug matrices layer
Containing the moisture for having more than 50%, easily keratoderma is made to soften, Drug Percutaneous Absorption effect is good.
Organic solvent, long-time service is used to have damage, preparation process also right skin in the technical process of traditional patch
Environment is harmful, and the present invention uses the patch of hydrogel matrix, and water content is high, the moisturizing phase is long, osmotic effect is good, and phase
Have the advantages that and skin good biocompatibility to traditional patch.Natural ginger oil composition hydrogel patch prepared by the present invention without
Stimulation and sensitization, and preparation process is simple, entire technological process is to operator's fanout free region, environmental protection, safety, to environment without dirt
Dye.
Specific implementation mode
In order to keep the technical purpose, technical solution and advantageous effect of the present invention clearer, with reference to specific embodiment
Technical scheme of the present invention is further illustrated, but the embodiment is intended to explain the present invention, and should not be understood as pair
The limitation of the present invention, in the examples where no specific technique or condition is specified, according to technology described in document in the art or
Condition is carried out according to product description.
Embodiment 1
A kind of natural ginger oil composition hydrogel patch, including back sheet, drug matrices layer and protective layer, the back sheet are nothing
Woven fabric, the protective layer be release polyester film, the drug matrices layer by containing ginger oil composition and hydrogel matrix be made, and
The quality of composition containing ginger oil is hydrogel matrix quality（In terms of the gross mass of hydrogel matrix raw material）2%；It is described to contain ginger
The composition of oil is made of the raw material of following parts by weight：40 parts of ginger oil, 20 parts of P-Cymene, 20 parts of nutmeg essential oil, peppermint
15 parts of essential oil, 5 parts of borneol essential oil；The hydrogel matrix is prepared from the following raw materials in parts by weight：50 parts of deionized water, third
15 parts of glycol, 15 parts of glycerine, 8 parts of Sodium Polyacrylate, 3 parts of polyvinylpyrrolidone, 3 parts of sodium carboxymethylcellulose, azone 2
Part, 1 part of superfine silica gel powder.
The preparation method of above-mentioned natural ginger oil composition hydrogel patch, includes the following steps：
（1）Each raw material of the composition containing ginger oil is weighed according to parts by weight, is uniformly mixed, is obtained the composition containing ginger oil；
Each raw material that hydrogel matrix is weighed according to parts by weight, moisturizer and penetrating agent are uniformly mixed, and obtain I phases, will be glued
Mixture and filler are dispersed in water successively, obtain II phases；
（2）According to the mass ratio of composition and hydrogel matrix containing ginger oil, step is weighed（1）The combination containing ginger oil of gained
Object, I phases and II phases；Composition containing ginger oil is scattered in I phases, is added into II phases, is stirred evenly in 45 DEG C；
（3）By step（2）Products therefrom is coated on by way of being coated with or spraying on back sheet（In every patch, contain ginger oil
Composition content be 1.5 mg/cm2）Afterwards, it repaves and covers protective layer, in vacuum drying chamber, 45 DEG C cure 10 hours；
（4）Sterilizing, be sliced to get.
Wherein, ginger oil, P-Cymene, nutmeg essential oil, Peppermint essential oil, borneol essential oil in the composition containing ginger oil
Respectively using ginger, folium artemisiae argyi, nutmeg fruit, dried peppermint leaf, borneol spiceleaf as raw material, is extracted and obtained using subcritical extraction method；Institute
The specific operation process for stating subcritical abstraction method is：Raw material is ground into powdery, in 40 DEG C, 3 times are extracted using butane, every time 45
Min, 0.5 MPa of extracting pressure, obtains extract liquor, then by extract liquor recycling butane to get.
Embodiment 2
A kind of natural ginger oil composition hydrogel patch, including back sheet, drug matrices layer and protective layer, the back sheet are nothing
Woven fabric, the protective layer be release polyester film, the drug matrices layer by containing ginger oil composition and hydrogel matrix be made, and
The quality of composition containing ginger oil is hydrogel matrix quality（In terms of the gross mass of hydrogel matrix raw material）1%；It is described to contain ginger
The composition of oil is made of the raw material of following parts by weight：50 parts of ginger oil, 30 parts of P-Cymene, 30 parts of nutmeg essential oil, peppermint
20 parts of essential oil, 10 parts of borneol essential oil；The hydrogel matrix is prepared from the following raw materials in parts by weight：60 parts of deionized water,
20 parts of propylene glycol, 20 parts of glycerine, 10 parts of Sodium Polyacrylate, 4 parts of polyvinylpyrrolidone, 4 parts of sodium carboxymethylcellulose, azone
3 parts, 3 parts of superfine silica gel powder.
Above-mentioned natural ginger oil composition hydrogel patch is prepared according to the method for embodiment 1.
Embodiment 3
A kind of natural ginger oil composition hydrogel patch, including back sheet, drug matrices layer and protective layer, the back sheet are nothing
Woven fabric, the protective layer be release polyester film, the drug matrices layer by containing ginger oil composition and hydrogel matrix be made, and
The quality of composition containing ginger oil is hydrogel matrix quality（In terms of the gross mass of hydrogel matrix raw material）3%；It is described to contain ginger
The composition of oil is made of the raw material of following parts by weight：30 parts of ginger oil, 10 parts of P-Cymene, 10 parts of nutmeg essential oil, peppermint
5 parts of essential oil, 2 parts of borneol essential oil；The hydrogel matrix is prepared from the following raw materials in parts by weight：40 parts of deionized water, third
12 parts of glycol, 12 parts of glycerine, 5 parts of Sodium Polyacrylate, 2 parts of polyvinylpyrrolidone, 2 parts of sodium carboxymethylcellulose, azone 1
Part, 2 parts of superfine silica gel powder.
Above-mentioned natural ginger oil composition hydrogel patch is prepared according to the method for embodiment 1.
Embodiment 4
A kind of natural ginger oil composition hydrogel patch, including back sheet, drug matrices layer and protective layer, the back sheet are nothing
Woven fabric, the protective layer be release polyester film, the drug matrices layer by containing ginger oil composition and hydrogel matrix be made, and
The quality of composition containing ginger oil is hydrogel matrix quality（In terms of the gross mass of hydrogel matrix raw material）4%；It is described to contain ginger
The composition of oil is made of the raw material of following parts by weight：20 parts of ginger oil, 5 parts of P-Cymene, 5 parts of nutmeg essential oil, peppermint essence
Oily 5 parts, 2 parts of borneol essential oil；The hydrogel matrix is prepared from the following raw materials in parts by weight：50 parts of deionized water, the third two
20 parts of alcohol, 12 parts of glycerine, 10 parts of Sodium Polyacrylate, 2 parts of polyvinylpyrrolidone, 2 parts of sodium carboxymethylcellulose, 2 parts of azone,
1 part of superfine silica gel powder.
The preparation method of above-mentioned natural ginger oil composition hydrogel patch, includes the following steps：
（1）Each raw material of the composition containing ginger oil is weighed according to parts by weight, is uniformly mixed, is obtained the composition containing ginger oil；
Each raw material that hydrogel matrix is weighed according to parts by weight, moisturizer and penetrating agent are uniformly mixed, and obtain I phases, will be glued
Mixture and filler are dispersed in water successively, obtain II phases；
（2）According to the mass ratio of composition and hydrogel matrix containing ginger oil, step is weighed（1）The combination containing ginger oil of gained
Object, I phases and II phases；Composition containing ginger oil is scattered in I phases, is added into II phases, is stirred evenly in 40 DEG C；
（3）By step（2）After products therefrom is coated on by way of being coated with or spraying on back sheet, repaves and covers protective layer,
In curing 15 hours in 40 DEG C of vacuum drying chambers；
（4）Sterilizing, be sliced to get.
Wherein, ginger oil, P-Cymene, nutmeg essential oil, Peppermint essential oil, borneol essential oil in the composition containing ginger oil
Respectively using ginger, folium artemisiae argyi, nutmeg fruit, dried peppermint leaf, borneol spiceleaf as raw material, is extracted and obtained using supercritical extraction method；Institute
The specific operation process for stating supercritical extraction is：Raw material is ground into powdery, in 45 DEG C, using supercritical CO2Fluid extraction 2
It is secondary, 40 min, 20 MPa of extracting pressure every time, collect extract to get.
Embodiment 5
A kind of natural ginger oil composition hydrogel patch, including back sheet, drug matrices layer and protective layer, the back sheet are nothing
Woven fabric, the protective layer be release polyester film, the drug matrices layer by containing ginger oil composition and hydrogel matrix be made, and
The quality of composition containing ginger oil is hydrogel matrix quality（In terms of the gross mass of hydrogel matrix raw material）5%；It is described to contain ginger
The composition of oil is made of the raw material of following parts by weight：5 parts of ginger oil, 3 parts of P-Cymene, 3 parts of nutmeg essential oil, Peppermint essential oil
2 parts, 1 part of borneol essential oil；The hydrogel matrix is prepared from the following raw materials in parts by weight：50 parts of deionized water, propylene glycol
12 parts, it is 20 parts of glycerine, 5 parts of Sodium Polyacrylate, 4 parts of polyvinylpyrrolidone, 4 parts of sodium carboxymethylcellulose, 2 parts of azone, micro-
2 parts of powder silica gel.
Above-mentioned natural ginger oil composition hydrogel patch is prepared according to the method for embodiment 4.
Comparative example 1
A kind of natural ginger oil composition hydrogel patch differs only in change hydrogel matrix according to the scheme of embodiment 1,
The hydrogel matrix is prepared from the following raw materials in parts by weight：30 parts of deionized water, 30 parts of glycerine, is gathered at 30 parts of propylene glycol
5 parts of sodium acrylate, 5 parts of polyvinylpyrrolidone, 5 parts of sodium carboxymethylcellulose, 0.5 part of azone, 0.5 part of superfine silica gel powder.
It is real that the natural ginger oil composition hydrogel patch prepared below to embodiment 1 and comparative example 1 carries out skin irritation
It tests.
Test material：Healthy rabbits, weight（2.0 scholars 0.5）Kg is provided by Zhengzhou University's Experimental Animal Center.
Test method：Healthy rabbits 15 are taken, are randomly divided into 3 groups, every group 5；Preceding 24 h of administration, rabbit back of being in depilation 3cm
×3cm.First group carries out single administration Skin Irritation Test using patch prepared by embodiment 1：After 24 h of single administration, observation
Situations such as removing 1 h, 24 h, 48 h and 72 h to one week smearing after patch whether there is or not erythema and oedema at position；Second group using real
The patch for applying the preparation of example 1 carries out multiple dosing Skin Irritation Test：After 1 24 h of administration, successive administration 5 days often pastes 24 h, so
After remove patch, l h, 24 h, 48 h, observation in 72 h to 1 weeks situations such as whether there is or not erythema and oedema；Third group uses comparative example 1
The patch of preparation carries out multiple dosing Skin Irritation Test：Process is the same as second group.
As a result, it has been found that first group and second group of third group do not occur oedema, erythema phenomenon, and to the hair of rabbit, row
It is all had no significant effect for indexs such as, stool and urine, weight, blood glucose, blood fat, internal organs naked eyes illustrate this hair without finding abnormal variation
The patch application of bright preparation is safe.There is slight erythema in 5 rabbit of third group, illustrate that the raw material proportioning of hydrogel matrix can shadow
Stimulation of Xiangshui County's gel-type vehicle to skin.
Selection 30 has the carsick volunteer reacted, and male 10, female 20 are 20 ~ 50 years old age, 30 years old average.By bus preceding 5
Minute is affixed at navel, everyone tests 5 times by bus, rides 50 minutes or more every time.After tested, 30 volunteers do not occur skin
Skin allergy, only volunteer also have carsick reaction for 5 times by bus, but compared with being relieved before medication.Illustrate this
Invent the patch for preparing to prevent and treat it is dizzy spit it is largely effective.
Embodiment 2 ~ 5 is with the natural ginger oil composition hydrogel patch obtained by embodiment 1 in the dizzy side of spitting of prevention and treatment
Face effect is suitable.In addition to this, the natural ginger oil composition hydrogel patch that prepared by embodiment 1 ~ 5 is affixed at temple, can be bright
It is aobvious to feel to refresh the mind；For arthralgia, the natural ginger oil composition hydrogel patch prepared using embodiment 1 ~ 5 also has bright
Show lenitive effect.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that：Its according to
So can with technical scheme described in the above embodiments is modified, either to which part or all technical features into
Row equivalent replacement；And these modifications or replacements, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (9)
1. a kind of natural ginger oil composition hydrogel patch, including back sheet, drug matrices layer and protective layer, it is characterised in that：
The drug matrices layer by containing ginger oil composition and hydrogel matrix be made, and the quality of the composition containing ginger oil be hydrogel
The 0.05 ~ 5% of matrix quality；
The composition containing ginger oil is made of the raw material of following parts by weight：5-50 parts of ginger oil, 3-30 parts of P-Cymene, Pork and beans
Cool essential oil 3-30 parts, 2-20 parts of Peppermint essential oil, 1-10 parts of borneol essential oil；
The hydrogel matrix is prepared from the following raw materials in parts by weight：40-60 parts of water, 24-40 parts of moisturizer, adhesive 9-18
Part, 1-3 parts of penetrating agent, 1-3 parts of filler.
2. natural ginger oil composition hydrogel patch according to claim 1, it is characterised in that：The moisturizer is by propylene glycol
And glycerine is formed according to 3-5: 3-5 mixing of mass ratio, described adhesive is by Sodium Polyacrylate, polyvinylpyrrolidone and carboxylic first
Base sodium cellulosate is formed according to 2.5-5: 1-2: 1-2 mixing of mass ratio, and the penetrating agent is azone, and the filler is micro mist silicon
Glue.
3. natural ginger oil composition hydrogel patch according to claim 2, which is characterized in that the hydrogel matrix by with
The raw material of lower parts by weight is made：50 parts of deionized water, 15 parts of propylene glycol, 15 parts of glycerine, 8 parts of Sodium Polyacrylate, polyethylene
3 parts of pyrrolidones, 3 parts of sodium carboxymethylcellulose, 2 parts of azone, 1 part of superfine silica gel powder.
4. natural ginger oil composition hydrogel patch according to claim 1, it is characterised in that：In drug matrices layer, contain ginger
The quality of the composition of oil is the 1-3% of hydrogel matrix quality.
5. natural ginger oil composition hydrogel patch according to claim 1, which is characterized in that the composition containing ginger oil
It is prepared from the following raw materials in parts by weight：40 parts of ginger oil, 20 parts of P-Cymene, 20 parts of nutmeg essential oil, 15 parts of Peppermint essential oil, dragon
5 parts of brain essential oil.
6. natural ginger oil composition hydrogel patch according to claim 1, which is characterized in that the back sheet is nonwoven
Cloth, the protective layer are the paper or polyester film by release treatment.
7. the preparation method of any natural ginger oil composition hydrogel patch of claim 1 to 6, which is characterized in that including
Following steps：
（1）Each raw material of the composition containing ginger oil is weighed according to parts by weight, is uniformly mixed, is obtained the composition containing ginger oil；
Each raw material that hydrogel matrix is weighed according to parts by weight, moisturizer and penetrating agent are uniformly mixed, and obtain I phases, will be glued
Mixture and filler are dispersed in water successively, obtain II phases；
（2）According to the mass ratio of composition and hydrogel matrix containing ginger oil, step is weighed（1）The combination containing ginger oil of gained
Object, I phases and II phases；Composition containing ginger oil is scattered in I phases, adds into II phases, is stirred evenly in 40-50 DEG C；
（3）By step（2）After products therefrom is coated on by way of being coated with or spraying on back sheet, repaves and covers protective layer,
In curing in vacuum drying chamber；
（4）Sterilizing, be sliced to get.
8. the preparation method of natural ginger oil composition hydrogel patch according to claim 6, it is characterised in that：It is described to contain ginger
Ginger oil, P-Cymene, nutmeg essential oil, Peppermint essential oil, borneol essential oil are respectively with ginger, folium artemisiae argyi, nutmeg in the composition of oil
Fruit, dried peppermint leaf, borneol spiceleaf are raw material, are extracted and are obtained using subcritical abstraction or supercritical extraction method；
The specific operation process of the subcritical abstraction method is：Raw material is ground into powdery, in 30-45 DEG C, is extracted using butane
Obtain extract liquor 1-3 times, each 35-45 min, extracting pressure 0.3-0.6 MPa, then by extract liquor recycling butane to get；
The specific operation process of the supercritical extraction is：Raw material is ground into powdery, in 30-55 DEG C, using supercritical CO2
Fluid extraction 1-3 times, each 35-45 min, extracting pressure 6-30 MPa, collect extract to get.
9. the preparation method of natural ginger oil composition hydrogel patch according to claim 6, it is characterised in that：The vacuum
Drying box temperature is 40-50 DEG C, and when solidification is 10-15 hours a length of.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810802693.4A CN108543051A (en) | 2018-07-20 | 2018-07-20 | A kind of natural ginger oil composition hydrogel patch and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810802693.4A CN108543051A (en) | 2018-07-20 | 2018-07-20 | A kind of natural ginger oil composition hydrogel patch and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108543051A true CN108543051A (en) | 2018-09-18 |
Family
ID=63492271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810802693.4A Pending CN108543051A (en) | 2018-07-20 | 2018-07-20 | A kind of natural ginger oil composition hydrogel patch and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108543051A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109432374A (en) * | 2018-12-21 | 2019-03-08 | 广州栋方生物科技股份有限公司 | A kind of massage oil and its preparation method and application |
| CN112245558A (en) * | 2020-10-30 | 2021-01-22 | 河南羚锐制药股份有限公司 | A hydrogel carsickness patch containing ginger oil and dried ginger powder |
| CN116919928A (en) * | 2023-06-26 | 2023-10-24 | 云南白药集团无锡药业有限公司 | Crocus sativus and notopterygium root shoulder warming patch and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101468187A (en) * | 2007-12-28 | 2009-07-01 | 天津市中宝制药有限公司 | Gel patch for treating motion sickness and preparation method thereof |
| CN106620514A (en) * | 2016-12-01 | 2017-05-10 | 湖北硅金凝节能减排科技有限公司 | Traditional Chinese medicine hydrophilic gel patch for treating dysmenorrheal and preparation method of traditional Chinese medicine hydrophilic gel patch |
| CN106692936A (en) * | 2017-02-09 | 2017-05-24 | 东莞市辛济生物科技有限公司 | Carsick patch |
-
2018
- 2018-07-20 CN CN201810802693.4A patent/CN108543051A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101468187A (en) * | 2007-12-28 | 2009-07-01 | 天津市中宝制药有限公司 | Gel patch for treating motion sickness and preparation method thereof |
| CN106620514A (en) * | 2016-12-01 | 2017-05-10 | 湖北硅金凝节能减排科技有限公司 | Traditional Chinese medicine hydrophilic gel patch for treating dysmenorrheal and preparation method of traditional Chinese medicine hydrophilic gel patch |
| CN106692936A (en) * | 2017-02-09 | 2017-05-24 | 东莞市辛济生物科技有限公司 | Carsick patch |
Non-Patent Citations (1)
| Title |
|---|
| 蒋肖男: "晕车贴 使用方便也有禁忌 ", 《健康向导》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109432374A (en) * | 2018-12-21 | 2019-03-08 | 广州栋方生物科技股份有限公司 | A kind of massage oil and its preparation method and application |
| CN112245558A (en) * | 2020-10-30 | 2021-01-22 | 河南羚锐制药股份有限公司 | A hydrogel carsickness patch containing ginger oil and dried ginger powder |
| CN116919928A (en) * | 2023-06-26 | 2023-10-24 | 云南白药集团无锡药业有限公司 | Crocus sativus and notopterygium root shoulder warming patch and preparation method thereof |
| CN116919928B (en) * | 2023-06-26 | 2024-03-19 | 云南白药集团无锡药业有限公司 | Crocus sativus and notopterygium root shoulder warming patch and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107616956A (en) | A kind of aloe skin care compositions and preparation method thereof | |
| CN108543051A (en) | A kind of natural ginger oil composition hydrogel patch and preparation method thereof | |
| CN109055048A (en) | A kind of pure natural moisturizing anti-acne handmade soap and its preparation method and application | |
| CN110585029A (en) | Traditional Chinese medicine herbal mask powder and preparation method and use method thereof | |
| CN108309854A (en) | A kind of lotus flower anti-aging cosmetics composition and its application | |
| CN108785200B (en) | Antibacterial, acne-removing and anti-wrinkle silver ion moisturizing mask liquid, mask and preparation method of mask | |
| KR101700132B1 (en) | Skin alleviating composition having continuous cooling effect | |
| CN107823004A (en) | Plant composition with anti-sunlight function and its application in sunscreen product | |
| CN112891504A (en) | Four-season skin-care epidemic-prevention ginger paste with ginger decoction dregs as base materials and preparation method | |
| CN113398222A (en) | National medicine composition for exorcising evil spirits and preventing epidemic | |
| CN102266422A (en) | Chinese medicinal preparation for treating slight and severe chilblains and production method thereof | |
| CN110917052A (en) | Coconut oil-containing moisturizing mask liquid, preparation method thereof and patch mask | |
| CN105435294A (en) | Bandage for diminishing inflammation and stopping bleeding of injury and preparation method thereof | |
| CN102488878A (en) | External traditional Chinese medicine composition for treating leucoderma | |
| CN108685805B (en) | Beauty-maintaining and beauty-maintaining Chinese mugwort carbon traditional Chinese medicine mask and preparation method and application thereof | |
| CN104095797B (en) | A kind of Herba Blumeae Balsamiferae compositions of speckle dispelling and application thereof | |
| CN111632006A (en) | Mosquito-repelling spray and preparation method thereof | |
| CN105920379A (en) | Traditional Chinese medicine eye cream to alleviate pouch and preparation method thereof | |
| CN105919907A (en) | Manufacturing method of traditional Chinese medicine eye cream and eye cream | |
| CN105902595A (en) | Sea buckthron oil-containing medicine for treating scalds, and preparation method of medicine | |
| CN105106085A (en) | Chinese medicinal herb sunscreen cream containing attapulgite | |
| CN1284345A (en) | Plaque dispelling mixture | |
| CN110623913A (en) | Traditional Chinese medicine deep acne-removing mask | |
| CN106334176B (en) | Chilblain ointment capable of relieving swelling, pain and itching and preparation method thereof | |
| CN115671239B (en) | Anti-inflammatory, detumescence, antibacterial, antipruritic, anticracking and repairing jelly-curing cream and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180918 |