CN108542992A - A kind of efficient anesthetic and preparation method thereof - Google Patents
A kind of efficient anesthetic and preparation method thereof Download PDFInfo
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- CN108542992A CN108542992A CN201810700833.7A CN201810700833A CN108542992A CN 108542992 A CN108542992 A CN 108542992A CN 201810700833 A CN201810700833 A CN 201810700833A CN 108542992 A CN108542992 A CN 108542992A
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Abstract
The invention discloses a kind of efficient anesthetic and preparation method thereof, belong to anaesthetic technical field.The drug is prepared by the raw material of following parts by weight：10 15 parts of frutus cnidii, 5 10 parts of peanut fresh leaf, 8 12 parts of spina date seed, 5 10 parts of green peel of walnut, 5 10 parts of datura flower, 13 parts of rhizoma cyperi, 13 parts of Rhizoma Chuanxiong, 0.02 0.05 parts of barbital, 80 120ml of organic solution.The present invention is made of multi-flavor medicinal material and barbital and organic solution compatibility, have the advantages that quick, the duration is long, anesthesia efficiency is high, post-operative recovery is fast, and it is postoperative by Anesthetics Metabolism and can excrete in time, confrontation the complication caused by anesthesia have good curative effect；The present invention also has hypnosis, calmness, analgesic effect apparent, Hemorrhagic shock, anti-arrhythmia, and the effect for preventing cardiovascular circulation from inhibiting.Acute toxicity and Local irritation study show that present composition safety is good, without side-effects.
Description
Technical field
The invention belongs to anaesthetic technical fields more particularly to a kind of efficient anesthetic and preparation method thereof.
Background technology
Anesthetic refers to that patient can be made whole or the local drug for being temporarily lost with feeling, can reach painless purpose, is hand
Art is treated or other medical examinations provide condition.In current clinical operation, anesthetic utilization rate is high, but sometimes for prolonging
Long operating time, if anaesthetic effect is bad, it will usually increase arcotic dosage, it is secondary anti-so as to cause different degrees of arcotic
It answers, common are cacesthesia, dysphoria, muscular tremor, convulsions, respiration inhibition etc..These side reactions generally require to grow very much
Recovery time, severe patient cannot even restore, and serious postoperative complication is caused to patient, endanger patient's post-operative recovery and strong
Health.
In recent years, with the fast development of medical research, Novel anesthetic gradually replaces traditional anesthetic, in operation fiber crops
It is used widely in liquor-saturated induction and maintenance.As Propofol have the advantages that it is rapid-action, but the drug hold time it is short and exist
Side effect, most notably breathing and cyclic inhibition when anesthesia induction directly inhibit due to human peripheral blood enlargement of pipe and heart
Double action, it is apparent to Cardiovascular System inhibiting effect when especially with inductive dose, it is mainly shown as low blood pressure,
For the drug with the raising of dosage and blood drug concentration, inhibiting effect is also more obvious simultaneously, and usually visible has breathing
Pause person.These disadvantages greatly restrict application and development of the Propofol in clinic, especially in elderly population, with year
The growth in age, brain can be more sensitive to Propofol, are also remarkably decreased to the clearance rate of Propofol, may cause because of blood flow in this way
Dynamic (dynamical) variation and lead to that depth of anesthesia is insufficient, Delayed recovery.
Currently, although clinical anesthesia medicine type is a lot of and has his own strong points, each anaesthetic, which can not be fully met, to be faced
The idealization standard of bed anesthesia.Although preoperative can reduce anaesthetic dosage using some drugs, such as Midazolam, narcoticness
Antalgesic, beta-blocker, calcium ion channel blockor, epiphysin etc., but it is also faced with such as influence psychomotor work(simultaneously
Energy, sleep pattern, haemodynamics and it is expensive the problems such as.Therefore, the dosage of arcotic how is reduced, fiber crops are mitigated
The side effect of liquor-saturated medicine reduces its adverse reaction, and reaches preferable anaesthetic effect, realize " balanced anesthesia ", " rationally anesthesia " at
To anaesthetize one of the problem in field.
103989825 A of patent CN disclose a kind of efficient anesthetic and preparation method thereof, and the medicine is by following parts by weight
Medicinal material is prepared：4-5 grams of keel, 4-5 grams of spina date seed, 3-4 grams of cortex albiziae, 3-4 grams of Root of Girald Larkspur, 4-5 grams of kamuning, Anisodus acutangulus
0.8-1 grams, 3-4 grams of radix aconiti agrestis, 3-4 grams of sensitive plant, 2-3 grams of the root bark of tree peony, 8-10 grams of sungpan monkshood root, 5-7 grams of pappy shell, 6-8 grams of semen brassicae,
3-5 grams of honeysuckle, 0-4 grams of pulchritudinous clubmoss herb, 0-5 grams of girald daphne bark.The drug is with quick, the duration is short, anesthesia efficiency is high, art
Finish the fast advantage of revival, postoperative by Anesthetics Metabolism and to excrete in time, confrontation complication caused by anesthesia has
Good curative effect；Also have analgesic effect apparent, the effect of Hemorrhagic shock.In addition, acute toxicity and Local irritation study show
Present composition safety is good, without side-effects.But the drug is prepared into using conventional Traditional medicine infusion method, leads to drug agent
Amount is big, and lacks the auxiliary agent drug for helping physical function to restore in drug, it is often more important that, only prepared with Chinese medicine compatibility,
It is relatively low that it anaesthetizes efficiency, it is difficult to meet the requirements.
Invention content
It is an object of the invention to：A kind of efficient anesthetic and preparation method thereof is provided, with Chinese medicine and barbital and
Organic solution compatibility is prepared into, and by Chinese medicine and barbital compatibility, not only increases the fiber crops of barbital and active ingredient of Chinese herbs
Liquor-saturated effect has achieved the purpose that reduce narcotic active ingredient dosage, moreover it is possible to prevent in anaesthesia process drug to blood pressure, breathing and
The inhibition of angiocarpy etc., while making narcotic active ingredient solvent with organic solution can not only promote anesthetic in the absorption of human body,
Achieve the effect that quick-anaesthesia, can more improve side effect of the narcotic active ingredient to blood circulation system.
To achieve the goals above, the present invention adopts the following technical scheme that：
A kind of efficient anesthetic, it is characterised in that：It is prepared by the raw material of following parts by weight：10-15 parts of frutus cnidii, peanut
5-10 parts of fresh leaf, 8-12 parts of spina date seed, 5-10 parts of green peel of walnut, 5-10 parts of datura flower, 1-3 parts of rhizoma cyperi, 1-3 parts of Rhizoma Chuanxiong, bar ratio
0.02-0.05 parts appropriate, organic solution 80-120ml.
Preferably, a kind of efficient anesthetic, it is characterised in that：It is prepared by the raw material of following parts by weight：Cnidium monnieri
12-15 parts sub-, 8-10 parts of peanut fresh leaf, 9-12 parts of spina date seed, 7-10 parts of green peel of walnut, 8-10 parts of datura flower, rhizoma cyperi 1.8-2.4
Part, 2-3 parts of Rhizoma Chuanxiong, 0.03-0.05 parts of barbital, organic solution 100-120ml.
It is further preferred that a kind of efficient anesthetic, it is characterised in that：It is prepared by the raw material of following parts by weight
At：15 parts of frutus cnidii, 9 parts of peanut fresh leaf, 10 parts of spina date seed, 8 parts of green peel of walnut, 9 parts of datura flower, 2.2 parts of rhizoma cyperi, Rhizoma Chuanxiong 2.5
Part, 0.04 part of barbital, organic solution 100ml.
Preferably, the organic solution is to be by volume by concentration 1.2-2mol/L light-coloured vinegars, glucose, fetal calf serum
100:3:1 ratio is mixed.
Preferably, the frutus cnidii, peanut fresh leaf, spina date seed, green peel of walnut, datura flower, rhizoma cyperi and Rhizoma Chuanxiong are Chinese medicine mark
Quasi- extracting solution.
The invention also discloses the preparation methods of above-mentioned efficient anesthetic, include the following steps：
1) barbital is completely dissolved in the sodium carbonate liquor of a concentration of 3mL5%, stays liquid spare；
2) above-mentioned each Chinese medical extract is substantially soluble in organic solution, under nitrogen protection, ice salt bath handles 30-60 points
Clock；
3) it is slowly stirred down, step 1) reserve liquid is added in the solution of step 2), then 20-30 points of ice salt bath processing
Clock, takes out and after magnetization treatment, efficient anesthetic is made in encapsulation.
Preferably, it is prepared into peroral dosage form using the above method.
The pharmacology analysis of each drug ingedient of the present invention is as follows：
Frutus cnidii：It is mild-natured, bitter；Return kidney channel.With tonifying the kidney and support yang, dispel pathogenic wind and remove dampness and the effect of desinsection.Pharmacological research table
It is bright, frutus cnidii also have relieving asthma, be antimycotic, eliminating the phlegm, anti-arrhythmia and local anesthetic action, the physical function in anaesthesia process is played
Fungal infection when protecting, prevent the function inhibitios such as blood pressure, breathing and angiocarpy, and can prevent from performing the operation, it is ensured that operation is suitable
Profit and safety carry out, and when it is shared with barbital, the cause that can be also obviously prolonged barbital is slept the time, improve anaesthetic effect.
Peanut fresh leaf：It is mild-natured, it is sweet in flavor, light；Return liver warp.The effect of with clearing heat and detoxicating, decompression of allaying excitement, tranquilizing soporific.
Spina date seed：It is mild-natured, it is sweet in flavor, sour；Return liver, courage, the heart channel of Hang-Shaoyin.With tonifying liver, calming heart, arrest sweating, promote the production of body fluid the effect of.Pharmacology is ground
Study carefully and shows that spina date seed also has calmness, hypnosis, anticonvulsion, analgesia, cooling, cardiac stimulant, expansion microvascular diameter and strengthen immunity
Effect, while to the hypnotic effect of barbital have facilitation.
Green peel of walnut：It is mild-natured, it is bitter, puckery；Return liver, spleen, stomach.Work(with analgesic, cough-relieving, antidiarrheal, removing toxic substances and desinsection
Effect.
Datura flower：It is warm-natured, acrid flavour；Return lung, Liver Channel.The effect of with antiasthmatic-antitussive, analgesia, spasmolysis.Pharmacological research shows
Datura flower also has calmness, Hemorrhagic shock, analgesia and improves sanguimotor effect, is widely used in Chinese drug anesthesia, with somnifacient
Object, which shares, can generate powerful synergistic effect.
Rhizoma cyperi：It is mild-natured, acrid flavour, slight bitter, micro-sweet；Return liver, spleen, tri-jiao channel.The effect of with promoting qi circulation and removing obstruction in the collateral, menstruction regulating and pain relieving.
Pharmacological research shows that rhizoma cyperi also has antipyretic-antalgic, antibacterial, anti-inflammatory and anesthetic effect, while can promote the syngignoscism of barbital,
It can more act synergistically with datura flower and enhance anaesthetic effect.
Rhizoma Chuanxiong：It is warm-natured, acrid flavour；Return liver, courage, pericardium channel.The effect of with blood-activating and qi-promoting, wind-expelling pain-stopping.Pharmacological research table
Bright, Rhizoma Chuanxiong also has antibacterial, calmness and the effect for improving cardiovascular circulation, while can enhance the hypnotic effect of barbital.
With Chinese medicine and barbital compatibility, can not only act synergistically the efficient anesthetic of the present invention promotion sleep, and enhance town
Quiet, analgesic effect achievees the purpose that improve anaesthetic effect, can more improve cardiovascular and blood circulation, prevents secondary in anaesthesia process
The generation of effect is additionally added rhizoma cyperi and Rhizoma Chuanxiong gas medicine in side, and postoperative patient qi and blood is helped to restore, and tire ox is added in organic solution
Serum can not only physiology of balance function, more can Balancing value, play the role of buffer anesthetic acidity.
Compared with prior art, of the invention effective to be：
The present invention is made of multi-flavor medicinal material and barbital and organic solution compatibility, with quick, the duration is long, anesthesia
Efficiency is high, the fast advantage of post-operative recovery, and it is postoperative by Anesthetics Metabolism and can excrete in time, fight caused by anesthesia
Complication has good curative effect；The present invention also has hypnosis, calmness, analgesic effect apparent, Hemorrhagic shock, anti-arrhythmia, and
The effect for preventing cardiovascular circulation from inhibiting.Acute toxicity and Local irritation study show that present composition safety is good, nothing
Side effect.
Specific implementation mode
Technical scheme of the present invention is described further with reference to specific embodiment, in order to same domain technical staff
Understanding.
A kind of efficient anesthetic, is prepared by the raw material of following parts by weight：15 parts of frutus cnidii, 9 parts of peanut fresh leaf, spina date seed
10 parts, 8 parts of green peel of walnut, 9 parts of datura flower, 2.2 parts of rhizoma cyperi, 2.5 parts of Rhizoma Chuanxiong, 0.04 part of barbital, organic solution 100ml,
In, it is 100 by volume that the organic solution, which is by concentration 1.2-2mol/L light-coloured vinegars, glucose, fetal calf serum,:3:1 ratio
It is mixed；The frutus cnidii, peanut fresh leaf, spina date seed, green peel of walnut, datura flower, rhizoma cyperi and Rhizoma Chuanxiong extract for Chinese medicine standard
Liquid；
Prepare raw material according to said ratio, is made by the steps into：
1) barbital is completely dissolved in the sodium carbonate liquor of a concentration of 3mL5%, stays liquid spare；
2) above-mentioned each Chinese medical extract is substantially soluble in organic solution, under nitrogen protection, ice salt bath handles 30-60 points
Clock；
3) it is slowly stirred down, step 1) reserve liquid is added in the solution of step 2), then 20-30 points of ice salt bath processing
Clock, takes out and after magnetization treatment, efficient anesthetic is made in encapsulation.
Embodiment 2
A kind of efficient anesthetic, is prepared by the raw material of following parts by weight：10 parts of frutus cnidii, 5 parts of peanut fresh leaf, spina date seed
8 parts, 5 parts of green peel of walnut, 5 parts of datura flower, 1 part of rhizoma cyperi, 1 part of Rhizoma Chuanxiong, 0.02 part of barbital, organic solution 80ml, wherein it is described
It is 100 by volume that organic solution, which is by concentration 1.2-2mol/L light-coloured vinegars, glucose, fetal calf serum,:3:1 ratio mixing system
At；The frutus cnidii, peanut fresh leaf, spina date seed, green peel of walnut, datura flower, rhizoma cyperi and Rhizoma Chuanxiong are Chinese medicine standard extracting solution；
Prepare raw material according to said ratio, is made by the steps into：
1) barbital is completely dissolved in the sodium carbonate liquor of a concentration of 3mL5%, stays liquid spare；
2) above-mentioned each Chinese medical extract is substantially soluble in organic solution, under nitrogen protection, ice salt bath handles 30-60 points
Clock；
3) it is slowly stirred down, step 1) reserve liquid is added in the solution of step 2), then 20-30 points of ice salt bath processing
Clock, takes out and after magnetization treatment, efficient anesthetic is made in encapsulation.
Embodiment 3
A kind of efficient anesthetic, is prepared by the raw material of following parts by weight：15 parts of frutus cnidii, 10 parts of peanut fresh leaf, wild jujube
12 parts of benevolence, 10 parts of green peel of walnut, 10 parts of datura flower, 2.4 parts of rhizoma cyperi, 3 parts of Rhizoma Chuanxiong, 0.05 part of barbital, organic solution 120ml,
Wherein, it is 100 by volume that the organic solution, which is by concentration 1.2-2mol/L light-coloured vinegars, glucose, fetal calf serum,:3:1 ratio
Example is mixed；The frutus cnidii, peanut fresh leaf, spina date seed, green peel of walnut, datura flower, rhizoma cyperi and Rhizoma Chuanxiong are that Chinese medicine standard carries
Take liquid；
Prepare raw material according to said ratio, is made by the steps into：
1) barbital is completely dissolved in the sodium carbonate liquor of a concentration of 3mL5%, stays liquid spare；
2) above-mentioned each Chinese medical extract is substantially soluble in organic solution, under nitrogen protection, ice salt bath handles 30-60 points
Clock；
3) it is slowly stirred down, step 1) reserve liquid is added in the solution of step 2), then 20-30 points of ice salt bath processing
Clock, takes out and after magnetization treatment, efficient anesthetic is made in encapsulation.
In experimental test, inventor is respectively to traditional Chinese medicine ingredients (B), the traditional Chinese medicine ingredients+organic in barbital (A), we
Solution (C), traditional Chinese medicine ingredients+barbital+organic solution (D) are tested, the results show that in same dosage, test fiber crops in D groups
Liquor-saturated effect is best, most short into the narcosis time, and continuous narcosis time longest；Anaesthetic effect is close with A groups in C groups, into
Enter that the narcosis time is close, and the duration is also essentially identical, but recovery time obviously earlier than A groups, and patient's vital essence after restoring
God is relatively preferable；Anaesthetic effect is worst in B groups, entry time longest, but recovery time is short, and energy is preferable after recovery.
The above testing experiment shows that traditional Chinese medicine ingredients act synergistically with barbital and organic solution with mutual in we, three
Person, which mutually cooperates with, reinforces anaesthetic effect, and single traditional Chinese medicine ingredients anaesthetic effect is poor, into narcosis time longest, illustrate it is pure in
Medicine anesthetic it is ineffective.
The present invention using traditional Chinese medicine ingredients and barbital and organic solution compatibility, both solved pure Chinese medicine anesthetic effect it is poor,
Slow problem is reacted, and enhances the anaesthetic effect of barbital, reduces its dosage, keeps anaesthetic safer and more effective.
Claims (6)
1. a kind of efficient anesthetic, it is characterised in that：It is prepared by the raw material of following parts by weight：10-15 parts of frutus cnidii, peanut are fresh
5-10 parts of leaf, 8-12 parts of spina date seed, 5-10 parts of green peel of walnut, 5-10 parts of datura flower, 1-3 parts of rhizoma cyperi, 1-3 parts of Rhizoma Chuanxiong, barbital
0.02-0.05 parts, organic solution 80-120ml.
2. a kind of efficient anesthetic as described in claim 1, it is characterised in that：It is prepared by the raw material of following parts by weight：Snake
12-15 parts of machine tool, 8-10 parts of peanut fresh leaf, 9-12 parts of spina date seed, 7-10 parts of green peel of walnut, 8-10 parts of datura flower, rhizoma cyperi 1.8-
2.4 parts, 2-3 parts of Rhizoma Chuanxiong, 0.03-0.05 parts of barbital, organic solution 100-120ml.
3. a kind of efficient anesthetic as claimed in claim 1 or 2, it is characterised in that：It is prepared by the raw material of following parts by weight：
15 parts of frutus cnidii, 9 parts of peanut fresh leaf, 10 parts of spina date seed, 8 parts of green peel of walnut, 9 parts of datura flower, 2.2 parts of rhizoma cyperi, 2.5 parts of Rhizoma Chuanxiong,
0.04 part of barbital, organic solution 100ml.
4. a kind of efficient anesthetic as described in claim 1-3 any one, it is characterised in that：The organic solution is by dense
It is 100 to spend 1.2-2mol/L light-coloured vinegars, glucose, fetal calf serum by volume:3:1 ratio is mixed.
5. a kind of efficient anesthetic as described in claim 1-3 any one, it is characterised in that：The frutus cnidii, peanut are fresh
Leaf, spina date seed, green peel of walnut, datura flower, rhizoma cyperi and Rhizoma Chuanxiong are Chinese medicine standard extracting solution.
6. a kind of preparation method of efficient anesthetic according to claim 1-3 any one, it is characterised in that：Including such as
Lower step：
1) barbital is completely dissolved in the sodium carbonate liquor of a concentration of 3mL5%, stays liquid spare；
2) above-mentioned each Chinese medical extract is substantially soluble in organic solution, under nitrogen protection, ice salt bath is handled 30-60 minutes；
3) it is slowly stirred down, step 1) reserve liquid is added in the solution of step 2), then ice salt bath is handled 20-30 minutes, is taken
Go out and after magnetization treatment, efficient anesthetic is made in encapsulation.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115364164A (en) * | 2022-07-13 | 2022-11-22 | 上海市中医医院 | Traditional Chinese medicine composition for treating liver depression type insomnia and application thereof |
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| CN105596615A (en) * | 2016-01-25 | 2016-05-25 | 青岛大学附属医院 | Anesthesia, analgesia and inflammation diminishing traditional Chinese medicine |
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