CN108525022B - A kind of slewing biodegrade hemostatic clamp and preparation method thereof - Google Patents
A kind of slewing biodegrade hemostatic clamp and preparation method thereof Download PDFInfo
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- CN108525022B CN108525022B CN201810334689.XA CN201810334689A CN108525022B CN 108525022 B CN108525022 B CN 108525022B CN 201810334689 A CN201810334689 A CN 201810334689A CN 108525022 B CN108525022 B CN 108525022B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/352—Working by laser beam, e.g. welding, cutting or boring for surface treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
Abstract
The invention belongs to embedded type medical device product fields, and in particular to a kind of slewing biodegrade hemostatic clamp and preparation method thereof.The hemostatic clamp outer surface and side are handled by laser surface modification.The hemostatic clamp outer surface and side have laser modified layer after laser surface modification, and degradation rate is faster than inside, it can be achieved that orientation degradation from the outside to the inside.
Description
Technical field
The invention belongs to embedded type medical device product fields, and in particular to a kind of slewing biodegrade hemostatic clamp and
Preparation method.
Background technique
Clinically when doing laparoscopic surgery, meeting ligation operation near sites can not suture or need not suture doctor
Bleeding blood vessel, avoid in surgical procedure and postoperative hemorrhage.There are two types of current closure techniques: first, with suture linear slit
Closed location is ligatured needed for closing, but the operating time is long, operating difficulty is big；Second, it is pressed from both sides using surgical hemostasis, folder closes bleeding blood
Pipe, operation is relatively easy, and haemostatic effect is preferable.Common hemostatic clamp material is mainly non-degradable metal material hemostatic clamp and can inhale
Receive macromolecule hemostatic clamp.
Non-degradable metal material hemostatic clamp includes silver brain clip, tantalum folder and titanium folder, and wherein titanium folder is that current laparoscopic surgery faces
The common hemostatic clamp of bed.Since titanium alloy density is small, specific strength is high, elasticity modulus is low, corrosion resistance is good, easy processing forms and raw
Object compatibility is good, therefore, is widely used in all kinds of medical devices.The place but titanium folder comes with some shortcomings: first, cause inflammation
Reaction is permanently present because titanium folder will not be degraded after implanting, when folder closed incomplete or position not at that time, can dissociate to
The complication such as inflammatory reaction are caused at other positions；Second, postoperative image check is influenced, because titanium absorbs x-ray and to ultrasound
The influence of wave, patient is postoperative when doing CT, B ultrasound etc. and checking, titanium presss from both sides the image that can interfere peripheral organs, influences the diagnosis of doctor；The
Three, it is conductive, if electric coagulating apparatus touches titanium folder accidentally, its surrounding tissue can be made to burn, increase the risk of operation；The
Four, increase body and the financial burden of patient, titanium presss from both sides in long-term existence body, will cause the psychological burden of patient, but passes through two
Secondary operation is taken out, and also will increase operation cost.
Currently, absorbable macromolecule hemostatic clamp is based on Lapro-Clip folder and ABSOLOK ligation nail clip.Lapro-Clip
Folder is made of inner and outer clamp clip, and inner clip material is poly- glycol carbonic acid, is absorbed by the body within usual 60~90 days；Outer clip is by polyglycolic acid
It is made, is absorbed within 180 days；Hydrolysis occurs in human body for Absorbable clips, and reaction product passes through breathing or urine and excrement
Etc. modes exclude.The ABSOLOK ligation nail clip of Johnson & Johnson, the U.S. uses polydioxanone (PPDO).Polydioxanone
(PPDO), in addition to excellent biological degradability, also with excellent physical mechanical property.But absorbable high score sub-folder
There is also some drawbacks: first, to avoid other tissues from squeezing into " tooth socket system ", the pincers of blood vessel enter more difficult sometimes；Second,
Folder closed end is to lock flute profile in, and both ends must be completely exposed to press from both sides completely and close, and patient need to dissociate longer lumen out, can just make to perform the operation
Smoothly, it is safely completed；Third, it is costly for titanium folder.
Zheng Yufeng etc. (Zheng Yufeng, the Qinling Mountains, the degradable metal such as Yang Ke Science Press, 2016:788-808) is introduced
: degradable metal mainly includes magnesium metal and ferrous metal etc., and magnesium metal degradation rate in physiological environment is too fast, and in corruption
The a large amount of liberations of hydrogen of meeting, limit application of the magnesium metal in biomedicine during erosion.
Ferro element is the necessary microelement of human body and the important component of some metalloprotein.Iron conduct can drop
Solution metal material has the advantage that excellent in mechanical performance, can be improved higher radial support intensity, to stenter to implant and ball
Capsule expansion technique requires simply, to perform the operation easy to implement；With good biocompatibility, corrosion product will not cause apparent inflammation
Disease reaction.
(M Peuster, P Wohlsein, M Br ü gmann, the et al.A novel approach to such as Peuster
temporary stenting:degradable cardiovascular stents produced from corrodible
metal-results 6-18 months after implantation into New Zealand white
Rabbits.Heart, 2001,86 (5): 563-569) it will be using 16 pure iron stenter to implant 16 made of laser cutting method
The lower row aorta of New Zealand White Rabbit, observes its biological safety and degradability.The results show that most of after implantation 1 year
Rack body be still completely present in blood vessel.Show that the degradation of pure iron bracket is partially slow.
The excessively slow problem of pure iron degradation rate limits it in the application in biomedicine.Therefore, it is directed at iron and iron closes
The research of gold, which focuses primarily upon, changes its chemical composition, heterogeneous microstructure and the new technology of preparing of use, to accelerate iron
And the corrosion rate of ferroalloy materials.
CN201510808275.2 discloses a kind of Absorbale magnesium alloy laparoscope hemostatic clamp and preparation method thereof.But
The patent does not solve the problems, such as that magnesium alloy degradation rate under physiological environment is too fast and non-uniform, and due to the power of magnesium alloy
It is poor to learn performance, is easy to appear crackle or fracture in hemostatic clamp corner.
CN201120412587.9 discloses a kind of Absorbale magnesium alloy tissue hemostatic clamp, and the clamp is open at one end, it
Remaining to be connected, the two sides of opening direction are symmetrical for its center line, and through slot is provided on inner wall.The technical solution of the patent is also deposited
In some problems: first, technical solution does not solve the degradation problem of magnesium metal.Serious point can occur when magnesium metal degradation
Erosion, causes to degrade uncontrollable, increases the application risk of magnesium metallic weapon；Second, the blood vessel clamping structure and tradition titanium of the patent
Press from both sides it is similar, but the tensile strength and plasticity due to magnesium metal material be far below titanium material, cause closing performance that cannot reach
It is required that；Third, the blood vessel clip are provided with through slot on inner wall, it may appear that serious cusp potential corrosion phenomenon, so that degradation speed herein
Rate accelerates, and causes fracture failure in the clamp short time.
CN201410156536.2 discloses a kind of metallic blood vessel folder and preparation method thereof that orientable degradation absorbs.It is described
Blood vessel clip upper arm, the outside of lower arm and inside have different heterogeneous microstructure and potential difference, and the crystallite dimension in outside is greater than
Crystallite dimension and the outside potential difference than on the inside of of inside are low, thus direction orientation drop from the outside to the inside after realizing blood vessel clip closure
Solution, but preparation process is more complex.
CN201710037395.6 discloses biodegradable ferrous alloy hemostatic clamp and preparation method thereof.The hemostatic clamp
In U-typed, antibacterial functions are had both, but pure iron metal has that degradation rate is slow to be solved not yet.
Summary of the invention
The first aspect of the present invention be to provide it is a kind of can fast degraded biologically iron and ferroalloy hemostatic clamp, the hemostatic clamp
Outer surface and side are handled by laser surface modification.The hemostatic clamp outer surface and side have after laser surface modification
Laser modified layer, degradation rate are faster than inside, it can be achieved that orientation degradation from the outside to the inside.
In one embodiment, the parameter of the laser surface modification are as follows: power: 5~15w, sweep spacing: 30~80
μm, scanning speed: 600~1000mm/s, modification 1~10 time.
In preferred embodiments, the laser modified layer has channel form structure, and width is between 10-30 μm, institute
Stating has arc band in groove, the spacing between the arc band is 5-15 μm.Further, in the laser modified layer
By weight containing the Fe of 3-7%2O3。
In another embodiment, corrosion electric current density of the hemostatic clamp in physiological environment is 5 × 10-6A·cm-2~7 × 10-6A·cm-2。
In yet another embodiment, the hemostatic clamp include upper arm, lower arm, tail portion, location structure, anti-skid structure and
Locking structure.The total length of the hemostatic clamp is 6~20mm, and width is 0.6~3mm, with a thickness of 1.4~4mm, tail inner side arc
Degree diameter is 0.6~2mm, and outside radian diameter is 1.4~4mm, and hemostatic clamp opening angle is 20 °~120 °.
Further, the location structure is cylinder or groove shapes, not only plays fixed function, but also be avoided that and closed in folder
Cheng Zhong, blood vessel enter tail structure.The anti-skid structure is " S " type band or " W " type band, can guarantee preferably to clamp blood
Pipe.The tail portion is " water droplet " shape, prevents tail portion during folder closes to be plastically deformed, influences closure effect and degradability
Energy.The upper arm, lower arm and tail structure constitute symmetrical structure.The upper arm is equipped with mutually matched self-locking with lower arm head
Structure；When folder closes blood vessel, blood vessel is placed between the upper and lower arm, by applying pressure, lower arm lock hook is along upper arm lock hook
Negative camber is caught in inside it, to form locking.The upper and lower arm head portion is not equipped with built-in buckle, after hemostatic clamp is closed
Without obvious protrusion, implant site soft tissue will not be injured.
The second aspect of the present invention be to provide described in one kind can fast degraded biologically iron and ferroalloy hemostatic clamp preparation
Method comprising following steps:
1) iron or ferroalloy plate of required thickness are chosen；
2) plate is processed by the way of laser cutting or wire cutting, obtains required hemostatic clamp；
3) laser surface modification, modified parameter are carried out to the hemostatic clamp outer surface prepared and two sides using laser
Are as follows: power: 5~15w, sweep spacing: 30~80 μm, scanning speed: 600~1000mm/s, modification 1~10 time；
4) hemostatic clamp after laser surface modification is put into dehydrated alcohol and carries out ultrasonic cleaning until any surface finish is without dirt
It takes out and dries after dye, obtain slewing biodegrade hemostatic clamp.
Advantages of the present invention:
1, prepared hemostatic clamp is iron or ferroalloy using material, and ferrous metal has good biocompatibility, such as attached
Shown in Fig. 2, after cell culture for 24 hours, some MC3T3-E1 cells are spread in Pure Iron Surface, it was demonstrated that ferrous metal has good biology
Compatibility.As shown in table 1, ferrous metal and magnesium metal phase are more excellent than mechanical property, have high-intensitive, high-ductility and high tenacity etc. excellent
Gesture.In addition, magnesium metal degradation rate is too fast, it not can guarantee and played a role during necessary treatment or recovery,
2, as shown in Fig. 3, after laser surface modification, degradation rate is faster than inside for hemostatic clamp outer surface and side,
Orientation degradation from the outside to the inside can be achieved.Outer surface is reduced by laser modified post-etching current potential, and degradation rate is accelerated, and is being dropped
Outside forms potential difference with inside in solution preocess, so that the orientation degradation of hemostatic clamp ecto-entad.
Detailed description of the invention
Fig. 1 (a) is the SEM shape appearance figure of pure Fe before laser surface modification；
Fig. 1 (b) is the SEM shape appearance figure of pure Fe after laser surface modification；
Fig. 2 be MC3T3-E1 cell culture for 24 hours after in Pure Iron Surface scatter diagram；
Fig. 3 be pure Fe preparation sample in 37 DEG C of SBF solution dynamic potential polarization curve: before 1- laser surface modification,
After 2- laser surface modification；
Fig. 4 is the structural schematic diagram of prepared slewing biodegrade hemostatic clamp；
Fig. 5 is the structural schematic diagram of prepared slewing biodegrade hemostatic clamp.
Specific embodiment
Also the present invention further can be understood by embodiment, wherein the embodiment illustrates some preparations or user
Method.It is to be appreciated, however, that these embodiments do not limit the present invention.The change of the invention of currently known or further exploitation
Change is considered within the scope of the invention described herein and claimed below.
Embodiment 1
A kind of slewing biodegrade hemostatic clamp is prepared, specific steps using degradable pure iron plate are as follows:
The first step, the pure iron plate for choosing 99.99% or more iron content do raw material.
Second step processes plate by the way of laser cutting, obtains required hemostatic clamp, structure such as attached drawing 3
Shown, blood vessel 1, hemostatic clamp lower arm 3, tail structure 4, upper arm lock hook 5, lower arm lock hook 6, band 7, is consolidated hemostatic clamp upper arm 2
Determine structure 8.Hemostatic clamp total length is 10mm, width 1mm, and with a thickness of 2mm, tail inner side radian diameter is 0.8mm, lateral arcs
Degree diameter is 2mm, and hemostatic clamp opening angle is 60 °.Band width is 0.1mm, is in 60 ° of angles with upper and lower arm.
In the present embodiment, when haemostatic clamp clamps hemostatic clamp, tail structure 4 and lower arm locking structure 6 play fixed function；On
The medial and lateral profile of arm lock hook 5 and lower arm lock hook 6 is smooth surface, when upper arm 2 and lower arm 3 are closed, lower arm lock hook 6
It is caught in inside it along 5 negative camber of upper arm lock hook, to form locking；Fixed structure 8 not only plays fixed function, but also is avoided that
During folder closes, blood vessel enters tail structure 4；Inner wall is equipped with " W " type band structure, can better lock onto closure.
Third step carries out laser surface to the hemostatic clamp outer surface prepared and two sides using picosecond optical fiber laser
It is modified, modified parameter are as follows: power: 5w, sweep spacing: 30 μm, scanning speed: 600mm/s, modification 1 time.
Hemostatic clamp after laser surface modification is put into dehydrated alcohol and carries out ultrasonic cleaning until any surface finish by the 4th step
It takes out and dries after pollution-free, obtain slewing biodegrade hemostatic clamp.
Energy spectrum analysis is carried out to the laser modified surface of the hemostatic clamp of acquisition, the results showed that, the laser modified table of hemostatic clamp
Contain 3.3% Fe in face2O3。
Embodiment 2
The modified parameter of step 3 is adjusted are as follows: power: 10w, sweep spacing: 60 μm, scanning speed: 800mm/s, it is modified
Processing 5 times.Other step parameters are same as Example 1.
Energy spectrum analysis is carried out to the laser modified surface of the hemostatic clamp of acquisition, the results showed that, the laser modified table of hemostatic clamp
Contain 4.6% Fe in face2O3。
Embodiment 3
The modified parameter of step 3 is adjusted are as follows: power: 15w, sweep spacing: 80 μm, scanning speed: 1000mm/s changes
Property processing 10 times.Other step parameters are same as Example 1.
Energy spectrum analysis is carried out to the laser modified surface of the hemostatic clamp of acquisition, the results showed that, the laser modified table of hemostatic clamp
Contain 6.8% Fe in face2O3。
Embodiment 4
Slewing biodegrade hemostatic clamp, specific preparation parameter and reality are prepared using Fe-35Mn (wt%) sheet alloy
It is identical to apply example 2.
Embodiment 5
Slewing biodegrade hemostatic clamp, specific preparation parameter and implementation are prepared using Fe-5Zn (wt%) sheet alloy
Example 2 is identical.
Comparative example 1
Hemostatic clamp is prepared using the pure iron plate of 1mm, specific preparation parameter is same as Example 2, without step 3
Laser surface modification.
Comparative example 2
Hemostatic clamp is prepared using Fe-5Zn (wt%) sheet alloy of 1mm, specific preparation parameter is same as Example 2, no
By the laser surface modification of step 3.
Test method: electrochemical corrosion test is carried out to above-mentioned sample, measures parameters of electrochemical corrosion.Electro-chemical test is set
Standby is CHI-660e type electrochemical workstation, and test macro is working electrode, platinum using traditional three-electrode system, i.e. sample to be tested
Piece (10mm × 10mm) is auxiliary electrode, and saturated calomel electrode is reference electrode；Corrosive liquid is SBF solution, ingredient such as following table institute
Show.To guarantee that sample surfaces have good electric conductivity, the sample back side and copper conductor are glued together by conduction, are then used
704 silicon rubber seal four sides of sample.Test process maintains 37 DEG C of isoperibol.When electro-chemical test, selection is opened first
Road potential measurement mode measures the variation of sample surfaces open circuit potential value in certain time and record, time is set as 2h, opens a way
Current potential reaches relatively steady state.When impedance spectrum (EIS) measures, the take-off potential of sample is set as open circuit potential, and surface is applied
Adding amplitude is the sine wave disturbance current potential of 5mV, and frequency sweeping ranges are 100kHz to 100mHz, and each dot cycle is tested 3 times.It is dynamic
When potential polarization curve determination, selection lower than open circuit potential 300mV to the potential test section for being higher than open circuit potential 500mV, from
Low potential is scanned to high potential direction, sweep speed 1mV/s.Corrosion potential (Ecorr), corrosion electric current density (icorr)
Equal electrochemical parameters are determined by polarization curve.
Configure the chemical component and content of 1000ml SBF solution
Test result:
Parameters of electrochemical corrosion (including Ecorr and icorr)
| Sample | Current potential (V/SCE) | Current density (× 10-6A·cm-2) |
| Embodiment 1 | -0.749 | 4.855 |
| Embodiment 2 | -0.738 | 7.055 |
| Embodiment 3 | -0.685 | 5.928 |
| Embodiment 4 | -0.729 | 27.650 |
| Embodiment 5 | -0.735 | 35.005 |
| Comparative example 1 | -0.471 | 0.522 |
| Comparative example 2 | -0.701 | 25.335 |
Electrochemical corrosion test show using preparation method of the present invention obtain iron and ferroalloy hemostatic clamp ratio without
The hemostatic clamp corrosion potential for crossing laser surface modification reduces, and corrosion current density increases, laser modified so that iron and iron close
The corrosion resistance of gold reduces, and corrosion rate increases, and after laser surface modification, groove occurs in surface, and surface area increases, and when corrosion contacts
Area increases, and modified surface roughness increases, and spot corrosion tendency increases, so that the corrosion resistance of material reduces, corrosion rate
Increase, achieves unexpected technical effect.It is of the present invention can be effective by the iron and ferroalloy of laser surface modification
Solve the problems, such as that ferrous metals degradation rate in human body is slow in the prior art, while the biocompatibility excellent based on ferrous metal
And mechanical property, vast market prospect is accompanied by hemostasis prepared by above-mentioned material.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (8)
1. one kind can fast degraded biologically iron and ferroalloy hemostatic clamp, laser surface is passed through in the hemostatic clamp outer surface and side
Modification, the hemostatic clamp outer surface and side have laser modified layer after laser surface modification, in degradation rate ratio
Side is fast, it can be achieved that orientation degradation from the outside to the inside；The parameter of the laser surface modification are as follows: power: 5~15w, between scanning
Every: 30~80 μm, scanning speed: 600~1000mm/s, modification 1~10 time；The laser modified layer has channel form knot
Structure, width have arc band between 10-30 μm in the groove, the spacing between the arc band is 5-15 μm.
2. hemostatic clamp according to claim 1, which is characterized in that contain 3- by weight in the laser modified layer
7% Fe2O3。
3. hemostatic clamp according to claim 1, which is characterized in that corrosion current of the hemostatic clamp in physiological environment is close
Degree is 5 × 10-6A·cm-2~7 × 10-6A·cm-2。
4. hemostatic clamp according to claim 1-3, which is characterized in that the hemostatic clamp includes upper arm, lower arm, tail
Portion, location structure, anti-skid structure and locking structure；The total length of the hemostatic clamp is 6~20mm, and width is 0.6~3mm,
With a thickness of 1.4~4mm, tail inner side radian diameter is 0.6~2mm, and outside radian diameter is 1.4~4mm, hemostatic clamp open-angle
Degree is 20 °~120 °.
5. hemostatic clamp according to claim 4, which is characterized in that the location structure is cylinder or groove shapes, is both risen
To fixed function, and it is avoided that blood vessel enters tail structure during folder closes.
6. a kind of hemostatic clamp according to claim 4, which is characterized in that the upper arm and lower arm head are equipped with and cooperate
Self-locking structure；When folder closes blood vessel, blood vessel is placed between the upper and lower arm, by applying pressure, lower arm lock hook is along upper arm
Lock hook negative camber is caught in inside it, to form locking；The upper and lower arm head portion is not equipped with built-in buckle, hemostatic clamp
Without obvious protrusion after closure, implant site soft tissue will not be injured.
7. a kind of hemostatic clamp according to claim 4, which is characterized in that the anti-skid structure is " S " type band or " W " type
Band can guarantee preferably to clamp blood vessel；The tail portion is " water droplet " shape, prevents tail portion plasticity during folder closes from becoming
Shape influences closure effect and degradation property；The upper arm, lower arm and tail structure constitute symmetrical structure.
8. a kind of preparation method of hemostatic clamp described in claim 1, it is characterised in that the following steps are included:
1) iron or ferroalloy plate of required thickness are chosen；
2) plate is processed by the way of laser cutting or wire cutting, obtains required hemostatic clamp；
3) laser surface modification, modified parameter are carried out to the hemostatic clamp outer surface prepared and two sides using laser are as follows:
Power: 5~15w, sweep spacing: 30~80 μm, scanning speed: 600~1000mm/s, modification 1~10 time；
4) hemostatic clamp after laser surface modification is put into dehydrated alcohol after carrying out ultrasonic cleaning until any surface finish is pollution-free
Taking-up is dried, and slewing biodegrade hemostatic clamp is obtained.
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| CN101254138A (en) * | 2008-03-28 | 2008-09-03 | 西北有色金属研究院 | Micropore processing method of bone repairing body rough surface |
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| CN102268626A (en) * | 2010-06-01 | 2011-12-07 | 上海工程技术大学 | Method for metal surface modification |
| CN102912171A (en) * | 2012-09-26 | 2013-02-06 | 中国科学院金属研究所 | Method for improving biodegradation rate of pure iron or iron alloy and application thereof |
| CN103892884A (en) * | 2014-04-17 | 2014-07-02 | 苏州奥芮济医疗科技有限公司 | Metal vascular clamp capable of being degraded and absorbed directionally and manufacturing method thereof |
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2018
- 2018-04-15 CN CN201810334689.XA patent/CN108525022B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101254138A (en) * | 2008-03-28 | 2008-09-03 | 西北有色金属研究院 | Micropore processing method of bone repairing body rough surface |
| CN101337090A (en) * | 2008-08-29 | 2009-01-07 | 乐普（北京）医疗器械股份有限公司 | Composite coating magnesium/magnesium alloy biology device and preparation method thereof |
| CN102268626A (en) * | 2010-06-01 | 2011-12-07 | 上海工程技术大学 | Method for metal surface modification |
| CN102912171A (en) * | 2012-09-26 | 2013-02-06 | 中国科学院金属研究所 | Method for improving biodegradation rate of pure iron or iron alloy and application thereof |
| CN103892884A (en) * | 2014-04-17 | 2014-07-02 | 苏州奥芮济医疗科技有限公司 | Metal vascular clamp capable of being degraded and absorbed directionally and manufacturing method thereof |
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