CN108514897A - A kind of micro-fluidic chip for middle school chemistry student experimenting - Google Patents
A kind of micro-fluidic chip for middle school chemistry student experimenting Download PDFInfo
- Publication number
- CN108514897A CN108514897A CN201810323023.4A CN201810323023A CN108514897A CN 108514897 A CN108514897 A CN 108514897A CN 201810323023 A CN201810323023 A CN 201810323023A CN 108514897 A CN108514897 A CN 108514897A
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- China
- Prior art keywords
- reaction
- reagent
- chip
- micro
- reaction tank
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- 238000006243 chemical reaction Methods 0.000 claims abstract description 49
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 48
- 239000007788 liquid Substances 0.000 claims abstract description 17
- 230000003139 buffering effect Effects 0.000 claims abstract description 14
- 239000000872 buffer Substances 0.000 claims abstract description 11
- 238000007039 two-step reaction Methods 0.000 claims abstract description 8
- 239000011521 glass Substances 0.000 claims description 6
- 239000005357 flat glass Substances 0.000 claims description 2
- 238000003672 processing method Methods 0.000 claims description 2
- 239000000126 substance Substances 0.000 abstract description 9
- 238000002474 experimental method Methods 0.000 abstract description 6
- 238000001514 detection method Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 7
- 238000004140 cleaning Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000002761 liquid phase assay Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The invention belongs to chemical detection devices technical fields, are related to a kind of micro-fluidic chip platform of middle school chemistry student experimenting.Chip buffers conduit, two reaction tanks and one outlet liquid storage tank by three reagent inlets and accordingly and forms.There are a cushioning fender, the buffering catheter opening of baffle both sides to be symmetric in reaction tank.Three reagent inlets and one outlet liquid storage tank are symmetric.The advantages such as two-step reaction may be implemented in the chip of the present invention, has dosage small at low cost, and operation is accurate, safety, observation facilitate, are a kind of middle school chemical experiment platform tools of Cheap highly effective.
Description
Technical field
The invention belongs to chemical detection devices technical fields, are related to a kind of micro-fluidic core for middle school chemistry student experimenting
Piece.
Background technology
The experimental implementation for having many liquid reactions in middle school chemical experiment passes through the large capacities such as traditional beaker, test tube
The problems such as container is operated, and big, operation that there are reagent dosages inaccurately, easily causes danger, is not easy to go deep into observation, thus limit
The participation of student's hands-on and acquisition of knowledge degree.
The present invention designs a kind of novel middle school chemical experiment micro-fluidic chip using microflow control technique, will be in experiment
Large capacity and operating process are integrated into the chip of a piece of volume very little, to reduce the chemical reagent consumption of reaction, are reduced
The wasting of resources；Dosage and the reaction time of reagent can accurately be manipulated；Because of chip interior environment opposing seal, to avoid
Reagent such as splashes out at the risk factors, so that the operator is more safely tested；Teaching in conjunction with laboratory of middle school is micro-
Mirror, minor change that can more intuitively in observing response system；It is connected by two-stage reaction pond, middle school chemistry reality may be implemented
Common two-step reaction in testing；After cleaning chip by normal glass cleaning process, it can also reuse.
Invention content
The present invention provides a kind of novel middle school chemical experiment micro-fluidic chip, which may be implemented two-step reaction, has
Have that dosage is small, the advantages such as operation is accurate, safety, observation facilitate, are a kind of middle school chemical experiment platform tools of Cheap highly effective.
In order to achieve the above object, technical scheme is as follows：
Two-step reaction may be implemented in a kind of micro-fluidic chip for middle school chemistry student experimenting, including three reagents enter
Mouth 1-1,1-2,1-3 and corresponding buffer channel 2-1,2-2,2-3,2-4, a reagent exit liquid storage tank 6 and its corresponding outlet are logical
Road 5, two reaction tanks 3-1,3-2.
By buffering conduit 2-3 series connection between reaction tank between two described reaction tanks 3-1, the 3-2, two-step reaction is realized.
Corresponding cushioning fender 4-1,4-2, the cushioning fender orientating reaction pond center of circle are equipped in reaction tank 3-1,3-2, baffle both sides are delayed
Catheter opening is rushed to be symmetric.One 3-1 of reaction tank is respectively by buffering conduit 2-1,2-2 and reagent one, reagent two
Entrance 1-1,1-2 connection；Two 3-1 of reaction tank is connected by buffering conduit 2-4 with three entrance 1-3 of reagent, while logical by exporting
Road 5 is connected with outlet liquid storage tank.
In the Each part, reagent inlet and outlet liquid storage tank diameter are all 2mm, buffer 500 μm of conduit width；
Two reaction tank diameter 8mm coincide with four times of object lens visual field sizes of common school microscope；Cushioning fender in reaction tank is long
Degree is 4mm, and the orientating reaction pond center of circle, width is 200 μm, and the buffering catheter opening of baffle both sides is symmetric.Three reagents
Entrance and one outlet liquid storage tank are symmetric.
All channels of the chip and chamber structure are completed using glass baseplate chip standard processing method, and with
Clean sheet glass bonded seal constitutes glass cake core.
The present invention use process be：
The first reagent is flowed into from one entrance 1-1 of reagent, and buffering conduit 2-1 along reagent one flows into one 3-1 of reaction tank, simultaneously
Second of reagent is flowed into from two entrance 1-2 of reagent, and buffering conduit 2-2 along reagent two flows into one 3-1 of reaction tank, is produced after reaction
Object buffers conduit 2-3 between reaction tank and flows into two 3-2 of reaction tank, and if any two-step reaction, then the third reagent is tried at first and second kind
Agent is flowed into after flowing into one 3-1 of reaction tank by three entrance 1-3 of reagent, and buffering conduit 2-4 through reagent three flows into two 3-2 of reaction tank, with
The reaction product of first two reagent continues to react in two 3-2 of reaction tank, most flows into outlet liquid storage tank through exit passageway 5 afterwards
6, and flow out chip eventually by chip outlet liquid storage tank 6.Cushioning fender 4-1,4-2 pass through when reaction solution injects in reaction tank
It temporarily separates and works as a buffer, in case reaction is carried out at buffering conduit outlet generates precipitation obstruction conduit.
The present invention is based on microflow control technique by the chip of middle school chemistry liquid-phase assay micro to a piece of very little, for operation
Person provides accurate manipulation, safety, the Chemical Experimental Platform tool that can go deep into observation；Also, it is clear by normal glass cleaning process
After washing inner passage, which can also reuse.
Description of the drawings
Fig. 1 microfluidic chip structure schematic diagrames；
In figure：One entrance of 1-1 reagents；Two entrance of 1-2 reagents；Three entrance of 1-3 reagents；2-1 reagents one buffer conduit；2-2
Reagent two buffers conduit；Conduit is buffered between 2-3 reaction tanks；2-4 reagents three buffer conduit；3-1 reaction tanks one；3-2 reaction tanks two；
Cushioning fender in 4-1 reaction tanks one；Cushioning fender in 4-2 reaction tanks two；5 exit passageways；6 outlet liquid storage tanks.
Specific implementation mode
Below in conjunction with attached drawing, the present invention will be further described.
Reagent injection is in such a way that syringe connects plastic catheter, by the reagent inlet of conduit other end access chip
Place, pushes away syringe piston and is injected.
Micro-fluidic chip is transparent glass-chip, has good chemical stability.The process of operation is as follows：It will
The first reagent buffers conduit 2-1 along reagent one and flows into one 3-1 of reaction tank, while by second from one entrance 1-1 injections of reagent
Reagent buffers conduit 2-2 along reagent two and flows into one 3-1 of reaction tank, product is along anti-after reaction from two entrance 1-2 injections of reagent
Conduit 2-3 is buffered between Ying Chi and flows into two 3-2 of reaction tank, is reacted then by the third reagent in first and second kind of reagent flow if any two steps
It is injected by three entrance 1-3 of reagent after entering one 3-1 of reaction tank, buffering conduit 2-4 through reagent three flows into two 3-2 of reaction tank, with preceding two
The reaction product of kind reagent continues to react in two 3-2 of reaction tank, and outlet liquid storage tank 6 is flowed into through exit passageway 5, eventually by
Chip exports liquid storage tank 6 and flows out chip.The face in two reaction tanks 3-1,3-2 is observed by naked eyes or ordinary optical microscope
Color, particle, bubble, the variations such as precipitation.
Waste reaction solution extraction stores up the outlet of conduit other end access chip in such a way that plastic catheter connects waste liquid cylinder
In liquid pool, the pressure change generated when being injected by syringe voluntarily flows out.
Claims (2)
1. a kind of micro-fluidic chip for middle school chemistry student experimenting, which is characterized in that the micro-fluidic chip can be real
Existing two-step reaction, including three reagent inlets (1-1,1-2,1-3) and corresponding buffer channel (2-1,2-2,2-3,2-4), one
Reagent exit liquid storage tank (6) and its corresponding exit passageway (5), two reaction tanks (3-1,3-2)；
It is connected between two reaction tanks (3-1,3-2) by buffering conduit (2-3) between reaction tank, realizes two-step reaction；
Corresponding cushioning fender (4-1,4-2), the cushioning fender orientating reaction pond center of circle, baffle both sides are equipped in reaction tank (3-1,3-2)
Buffering catheter opening be symmetric；
The reaction tank one (3-1) is respectively by buffering conduit (2-1,2-2) and reagent one, two entrance of reagent (1-1,1-2)
Connection；Reaction tank two (3-1) is connected by buffering conduit (2-4) with three entrance of reagent (1-3), while passing through exit passageway (5)
It is connected with outlet liquid storage tank (6)；Wherein, three reagent inlets and one outlet liquid storage tank (6) are symmetric；
In the Each part, two reaction tank (3-1,3-2) diameter 8mm；Cushioning fender (4-1,4-2) in reaction tank
Length is 4mm, and width is 200 μm.
2. a kind of micro-fluidic chip for middle school chemistry student experimenting according to claim 1, which is characterized in that described
All channels of chip and chamber structure completed using glass baseplate chip standard processing method, and with clean sheet glass
Bonded seal constitutes glass cake core.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810323023.4A CN108514897A (en) | 2018-04-11 | 2018-04-11 | A kind of micro-fluidic chip for middle school chemistry student experimenting |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810323023.4A CN108514897A (en) | 2018-04-11 | 2018-04-11 | A kind of micro-fluidic chip for middle school chemistry student experimenting |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108514897A true CN108514897A (en) | 2018-09-11 |
Family
ID=63432401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810323023.4A Withdrawn CN108514897A (en) | 2018-04-11 | 2018-04-11 | A kind of micro-fluidic chip for middle school chemistry student experimenting |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108514897A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1208464A (en) * | 1995-12-05 | 1999-02-17 | 盖默拉生物科学公司 | Device and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics |
| JPH11200799A (en) * | 1998-01-16 | 1999-07-27 | Katekkusu:Kk | Mixing unit |
| US20130294981A1 (en) * | 2008-06-26 | 2013-11-07 | Fujikura Kasei Co., Ltd. | Liquid channel device and production method therefor |
| CN106378216A (en) * | 2016-11-09 | 2017-02-08 | 杭州电子科技大学 | Particle separator based on negative magnetophoresis technology |
| CN206139213U (en) * | 2016-11-10 | 2017-05-03 | 唐山学院 | Heat preservation dropping liquid experimental apparatus of a body structure |
| CN106984368A (en) * | 2017-03-30 | 2017-07-28 | 安徽理工大学 | A kind of hepatitis B controlled based on pump valve examines micro-fluidic chip and analysis method soon |
| CN208373115U (en) * | 2018-04-11 | 2019-01-15 | 刘涵青 | A kind of micro-fluidic chip for middle school chemistry student experimenting |
-
2018
- 2018-04-11 CN CN201810323023.4A patent/CN108514897A/en not_active Withdrawn
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1208464A (en) * | 1995-12-05 | 1999-02-17 | 盖默拉生物科学公司 | Device and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics |
| JPH11200799A (en) * | 1998-01-16 | 1999-07-27 | Katekkusu:Kk | Mixing unit |
| US20130294981A1 (en) * | 2008-06-26 | 2013-11-07 | Fujikura Kasei Co., Ltd. | Liquid channel device and production method therefor |
| CN106378216A (en) * | 2016-11-09 | 2017-02-08 | 杭州电子科技大学 | Particle separator based on negative magnetophoresis technology |
| CN206139213U (en) * | 2016-11-10 | 2017-05-03 | 唐山学院 | Heat preservation dropping liquid experimental apparatus of a body structure |
| CN106984368A (en) * | 2017-03-30 | 2017-07-28 | 安徽理工大学 | A kind of hepatitis B controlled based on pump valve examines micro-fluidic chip and analysis method soon |
| CN208373115U (en) * | 2018-04-11 | 2019-01-15 | 刘涵青 | A kind of micro-fluidic chip for middle school chemistry student experimenting |
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|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180911 |