CN108514658A - A kind of bionical tubular material - Google Patents
A kind of bionical tubular material Download PDFInfo
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- CN108514658A CN108514658A CN201810310820.9A CN201810310820A CN108514658A CN 108514658 A CN108514658 A CN 108514658A CN 201810310820 A CN201810310820 A CN 201810310820A CN 108514658 A CN108514658 A CN 108514658A
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- bionical
- periosteum
- tubular material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/22—Materials or treatment for tissue regeneration for reconstruction of hollow organs, e.g. bladder, esophagus, urether, uterus
Abstract
The present invention relates to a kind of bionical tubular materials, it is made of base's periosteum and contact periosteum, wherein base's periosteum is placed in the centre of two contact periosteums, it is characterized in that, base's periosteum is made of nondegradable high molecular polymer, contact periosteum is made of biodegradable material, and three-layer pipe film is closely combined with each other, and the surfacing of anti-adhesion biomimetic repair membrane.The nondegradable high molecular polymer is one or more in nondegradable polyester, polyethylene, polypropylene, polytetrafluoroethylene (PTFE).The degradable high molecular polymer is one or more in degradable hyaluronic acid, collagen, chitosan, polylactic acid, polyglycolide, polydioxanone, polyhydroxyalkanoate.
Description
Technical field
The invention belongs to medical material tech fields, are mainly used for the reparation of human body tubular tissue.
Background technology
Tubular material is commonly used in surgical operation, the human body tubular tissue for substituting lesion or being destroyed, such as blood vessel,
Enteron aisle etc..Though autologous transplanting material is good to repair safe and compatible property, the destruction again of tissue can be caused after all, and
And some tubular tissues can not be transplanted.Therefore, artificial bionical tubular material becomes research hotspot.
The tubular material for the biocompatibility used in operation is the most key.At present there are mainly two types of, one is intensity compared with
Height, but pipe made of nondegradable polymeric membrane, another kind is the preferable Biodegradable high-molecular film system of biocompatibility
At pipe.
Although the biological prosthetic film flexibility of polyester is good but tensile energy is weak, having many long term complications, (recurrence rate is
34%, infection rate 12%, intestinal obstruction 12%, intestinal fistula incidence 16%), the swollen incidence of fibroid slurries is also very high；It is poly-
The biological prosthetic film of propylene (Polypropylene Mesh, Marlex, PP) is woven by polypropylene fibre, is reticular structure,
It is the patching material of current most common abdominal-wall defect.With obvious advantage below：(1) more soft, more resistant to by bending and folding
It is folded；(2) it size can cut out with the need；(3) stimulation proliferation of fibrous tissue, which acts on, becomes apparent from, and mesh aperture is big, more conducively fiber group
Knit growth across, easily infiltrated by connective tissue, can early stage it is chimeric with tissue；(4) foreign body reaction is slight, and patient is without apparent foreign matter
And sense of discomfort, there is very low recurrence rate and complication rate；(5) more resistant to infected, even if the granulation group in infected wound
Knit still can be proliferated in the mesh of biological prosthetic film, do not cause mesh sheet corrode or tunnel；(6) there is higher anti-tensile strong
Degree；(7) it is not influenced by water and most of chemical substances；(8) high temperature resistant, can scalding；(9) price is relatively cheap.Although
It has been found to be implant most popular in current surgical implantation field, but there is also some in the application for polypropylene net
Problem：First, when being repaired for stomach wall full-thickness defects, biological prosthetic film will be isolated with viscera tissue, if itself and internal organs
More serious abdominal cavity adhesion, digestive obstruetion can be caused by being in direct contact, in some instances it may even be possible to be corroded intestinal wall, be caused intestinal fistula, increase patient
Pain even need second operation to take out biological prosthetic film.Expanded polytetrafluoroethylsealing prevents adhesion repair membrane (Expanded
Polytetrafluoroethyl e-PTFE):It is more soft compared with the biological prosthetic film of polypropylene, when being contacted with abdominal viscera not
Adhesion is easily formed, caused inflammatory reaction is also most light；But expanded polytetrafluoroethylsealing prevents adhesion, biological prosthetic film mesh is small, can
Bacterium is allowed to pass through, and phagocyte cannot pass through, tissue is not easy to grow into, therefore it is not resistant to infect and pollute, Bu Nengyong
In the wound of pollution, once infection biological repair membrane will take out, otherwise wound is difficult healing.
In addition, the irregular surface of these repair membranes may stimulate and damage surrounding tissue, cause infection and skin sinus
It is formed.Chronic inflammation processes can be induced by repairing membrane material, and the negative result of inflammatory process is to make complication：Infection, blood
Clear swollen, chronic ache etc..
Existing absorbable biological repair membrane such as polyglycolic acid, polylactic-co-glycolic acid etc., because of limited mechanical properties, no
It can only be used as temporary repairing separately as permanent patching material and patient helped to spend the disease risk phase, finally also use not
Absorbable biological repair membrane does permanent repairing.The emerging biological prosthetic film of collagen class, such as extracellular matrix, it is degradable, and have
There is the features such as good tolerance infection ability, has greater advantage compared to other clinically used synthetic materials, however
But there is the insufficient risk of mechanical performance at a specified future date, it is possible to operative failure, Postoperative recurrent rate be caused to increase.
Invention content
Technical problem to be solved by the invention is to provide a kind of bionical tubular materials, are provided simultaneously with excellent anti-repulsion and exempt from
Epidemic disease performance and excellent mechanical property, surfacing expand very little after water suction, avoid causing swollen tissue, and can load medicine
Object.
For non-degradable material and biodegradable material, its respective advantage, mutual tonifying for the deficiency are utilized：It can using biology
The advantages such as degradable material (hyaluronic acid/collagen/chitosan etc.) prevents adhesion, degradable, and histocompatbility is good, with non-degradable material
The good long term mechanical strength that continues of material (polypropylene/polyester/polytetrafluoroethylene (PTFE) etc.) is combined, and forms composite material.Polypropylene
Repair membrane is because surface is relatively rough, when being repaired for stomach wall full-thickness defects, if be in direct contact with internal organs, may corrode
Intestinal wall causes intestinal fistula, but has mesh larger, is grown into conducive to surrounding tissue and its intrusion of macrophage, is not easy in twine hidden
Hide bacterium, anti-infection ability and all relatively good advantage of maintenance.The good biodegradable material of histocompatbility is compound
Onto nondegradable polymer material, using nondegradable polymer material as bone, using biodegradable material as meat, it is made
Existing good histocompatbility, and have the good bionical complex repairation film for continuing mechanical strength at a specified future date.
This invention takes following technical solutions：
A kind of bionical tubular material is made of base's periosteum and contact periosteum, and wherein base's periosteum is placed in two contacting pipes
The centre of film, which is characterized in that base's periosteum is made of nondegradable high molecular polymer, and contact periosteum is by biodegradable
Material is made, and three-layer pipe film is closely combined with each other, and the surfacing of anti-adhesion biomimetic repair membrane.
Wherein, the nondegradable high molecular polymer is nondegradable polyester, polyethylene, polypropylene, polytetrafluoro
It is one or more in ethylene.
Wherein, the degradable high molecular polymer is degradable hyaluronic acid, collagen, chitosan, poly- breast
It is one or more in acid, polyglycolide, polydioxanone, polyhydroxyalkanoate.
Wherein, the degradable high molecular polymer is the collagen for holding peptide.
The degradable high molecular polymer is porous structure.
Base's periosteum is netted periosteum.
Its pipe thickness is 0.01-3mm.
A kind of preparation method of bionical tubular material, includes the following steps：
1) by netted braided fabric is clipped made of nondegradable macromolecule polymer material, is sewn into tubulose, and will
Two pipes
Shape braided fabric is nested together, and then cleans, sterilizes, then after being impregnated with ionic liquid, the referred to as double-deck webmaster；
2) biodegradable material is dissolved with solvent, obtains solution, for use；
3) acquired solution in step 2) is injected into cylindrical die, thickness is bigger 2~10mm than the diameter of the double-deck webmaster；It will step
It is rapid 1) in Double-level Reticulated pipe sleeve on glass bar or stainless steel bar, the diameter of glass bar or stainless steel bar is equal to the interior of internal layer webmaster
Then diameter is put in the solution in mold, the double-deck webmaster on the thickness direction of solution be located at centre, dipping after a certain period of time,
It takes out and dries, then further according to the thickness requirement of bionics prosthesis tubular material, repeat 0-10 dipping, dry step；
4) biodegradable material in the product after drying in step 3) is crosslinked, obtains final products, tube wall
Thickness be 0.01-3mm.
Wherein, in the solution in the step 2) biodegradable material a concentration of 0.3wt%~50wt%.
Drying in the step 3) is to air-dry, dry.
The step 3) can also be freeze-drying, cylindrical shape is then rolled into, again by step 3) repetitive operation
It after primary, air-dry or dries, form the compound of the double-deck biodegradable material.
The surface of the bionical tubular material of the present invention is shiny surface, can be formed air-drying, by way of drying or freeze-drying.
The mechanical strength of bionical tubular material is good, and wet tensile intensity is divided into two sections of intensity, and first stage tensile strength reaches
10MPa or more, for second stage tensile strength up to 60MPa or more, first stage tensile strength is contact film strength, second-order
Section tensile strength generates for base film layer, and the structure of two sections of tensile strength can fight the pressure from soft tissue, and it is disconnected to reduce material
The risk split.
The bionical tubular material contact membranes of the present invention are degradation material, it is possible to reduce lipid, thrombus or other substances are heavy
Product.
The bionical tubular material of the present invention can flexibly make to use it to medicament-carried, facilitate material benefit, while degradation material
There is slow releasing function to drug.After adding taxol, rapamycin, arsenic trioxide in contact membranes, tubulose can effectively prevent
Because thrombus deposition causes hemadostewnosis in material.
The bionical tubular material of the present invention has the expansion rate no more than 180%, after being used for human body, it is possible to prevente effectively from group
Swelling is knitted, foreign body sensation is reduced, reduces infection odds.
For the bionical tubular material of the present invention with contact membranes and base film layer with two-stage structure, base film layer provides enough power
Intensity is learned, and has the mechanical strength there are two the stage, it is ensured that tubular material can bear enough pressure, reduce tubular material
The possibility of rupture, contact membranes can increase the biocompatibility for repairing membrane material, while material is degradable, melts with autologous tissue
It is integrated, while reducing because of lipidosis, to reduce narrow possibility.
The base film layer of the present invention can greatly improve the hydrophilic ability on surface, enhance it and connect after ionic liquid impregnates
The binding force of contact layer prevents splitting, improves service life.
Specific implementation mode
Embodiment 1：
A kind of collagen and novel bionic tubular material made of polypropylene composite materials, base's periosteum are polypropylene net, are connect
It is collagen to touch periosteum, after the two is compound, then is once crosslinked to collagen.Preparation method is：
1)：It is managed by netted braided fabric is clipped made of nondegradable polypropylene fibre, is sewn into tubulose, and by two
Shape braided fabric is nested together, and then cleans, sterilizes, then after being impregnated with ionic liquid, the referred to as double-deck webmaster；
2)：By Atelocollagen albumen water dissolution, solution is obtained, for use；
3)：Acquired solution in step 2) is injected into cylindrical die, thickness is bigger 3mm than the diameter of the double-deck webmaster；By step
1) for the Double-level Reticulated pipe sleeve on stainless steel bar, the diameter of stainless steel bar is equal to the internal diameter of internal layer webmaster, is then put in mold
Solution in, the double-deck webmaster is located at centre on the thickness direction of solution, after impregnating 0.5h, drying is taken out, then further according to imitative
The raw thickness requirement for repairing tubular material, be repeated 2 times dipping, drying step；
4) biodegradable material in the product after drying in step 3) is crosslinked, obtains final products, tube wall
Thickness be 0.6mm.
Wherein, in the solution in the step 2) biodegradable material a concentration of 1wt%.
Drying in the step 3) is 25 DEG C of drying.
Polypropylene and the compound double layered tubular material of Atelocollagen albumen are obtained through above step.
Embodiment 2：
A kind of collagen and novel bionic tubular material made of polypropylene composite materials, base's periosteum are polypropylene net, are connect
It is collagen and Sodium Hyaluronate to touch periosteum, after the two is compound, then is once crosslinked to collagen.Preparation method
For：
1)：It is managed by netted braided fabric is clipped made of nondegradable polypropylene fibre, is sewn into tubulose, and by two
Shape braided fabric is nested together, and then cleans, sterilizes, then after being impregnated with ionic liquid, the referred to as double-deck webmaster；
2)：Atelocollagen albumen and Sodium Hyaluronate are used into water dissolution respectively, obtain solution, for use；
3)：Acquired solution in step 2) is injected into cylindrical die, thickness is bigger 3mm than the diameter of the double-deck webmaster；By step
1) for the Double-level Reticulated pipe sleeve on glass bar, the diameter of glass bar is equal to the internal diameter of internal layer webmaster, is then put in molten in mold
In liquid, the double-deck webmaster on the thickness direction of solution be located at centre, impregnate 1h after, take out drying, then further according to bionics prosthesis
The thickness requirement of tubular material, be repeated 3 times dipping, drying step, the 4th impregnate when use sodium hyaluronate solution；
4) biodegradable material in the product after drying in step 3) is crosslinked, obtains final products, tube wall
Thickness be 0.8mm.
Wherein, in the solution in the step 2) biodegradable material a concentration of 1wt%.
Drying in the step 3) air-dries for room temperature.
Polypropylene, Atelocollagen albumen and the compound double layered tubular material of Sodium Hyaluronate are obtained through above step.
Embodiment 3：
A kind of collagen and novel bionic tubular material made of polypropylene composite materials, base's periosteum are polypropylene net, are connect
It is collagen to touch periosteum, and adds taxol, after the two is compound, then is once crosslinked to collagen.Preparation method
For：
1)：It is managed by netted braided fabric is clipped made of nondegradable polypropylene fibre, is sewn into tubulose, and by two
Shape braided fabric is nested together, and then cleans, sterilizes, then after being impregnated with ionic liquid, the referred to as double-deck webmaster；
2)：By Atelocollagen albumen water dissolution, for use；
3)：Acquired solution in step 2) is injected into cylindrical die, thickness is bigger 3mm than the diameter of the double-deck webmaster；By step
1) for the Double-level Reticulated pipe sleeve on stainless steel bar, the diameter of stainless steel bar is equal to the internal diameter of internal layer webmaster, is then put in mold
Solution in, the double-deck webmaster on the thickness direction of solution be located at centre, impregnate 1h after, take out drying, then further according to bionical
Repair tubular material thickness requirement, be repeated 4 times dipping, drying step；
4) biodegradable material in the product after drying in step 3) is crosslinked, obtains final products, tube wall
Thickness be 1.3mm.
Wherein, in the solution in the step 2) biodegradable material a concentration of 1.5wt%.
Drying in the step 3) is 30 DEG C of drying.
Polypropylene and the compound double layered tubular material containing drug of Atelocollagen albumen are obtained through above step.
Embodiment 4：
A kind of collagen and novel bionic tubular material made of polypropylene composite materials, base's periosteum are polypropylene net, are connect
It is collagen to touch periosteum, after the two is compound, then is once crosslinked to collagen.Preparation method is：
1)：It is managed by netted braided fabric is clipped made of nondegradable polypropylene fibre, is sewn into tubulose, and by two
Shape braided fabric is nested together, and then cleans, sterilizes, then after being impregnated with ionic liquid, the referred to as double-deck webmaster；
2)：By Atelocollagen albumen water dissolution, for use；
3)：Acquired solution in step 2) is injected into cylindrical die, thickness is bigger 3mm than the diameter of the double-deck webmaster；By step
1) for the Double-level Reticulated pipe sleeve on stainless steel bar, the diameter of stainless steel bar is equal to the internal diameter of internal layer webmaster, is then put in mold
Solution in, the double-deck webmaster on the thickness direction of solution be located at centre, impregnate 1h after, take out drying, then further according to bionical
Repair tubular material thickness requirement, be repeated 5 times dipping, drying step；
4) biodegradable material in the product after drying in step 3) is crosslinked, obtains final products, tube wall
Thickness be 1.5mm.
Wherein, in the solution in the step 2) biodegradable material a concentration of 1.0wt%.
Drying in the step 3) is 30 DEG C of drying.
Polypropylene and the compound double layered tubular material containing drug of Atelocollagen albumen are obtained through above step.
Comparative example 1：
Novel bionic tubular material made of a kind of collagen, base film layer and contact periosteum are all collagens, are made
After tubular material, it is crosslinked.Preparation method is：
1)：By Atelocollagen albumen water dissolution, solution is obtained, for use；
2)：Acquired solution in step 1) is injected into cylindrical die, thickness is bigger 3mm than the diameter of the double-deck webmaster；By glass
Then cup is put in the solution in mold, the diameter of glass bar is equal to the internal diameter of internal layer webmaster, after impregnating 1h, takes out drying, so
Afterwards further according to the thickness requirement of bionics prosthesis tubular material, be repeated 3 times dipping, drying step；
3) biodegradable material in the product after drying in step 2) is crosslinked, obtains final products, tube wall
Thickness be 0.6mm.
Wherein, in the solution in the step 2) biodegradable material a concentration of 1wt%.
Drying in the step 3) is 25 DEG C of drying.
The compound tubular material of multilayer collagen is obtained through above step.
Comparative example 2：
A kind of collagen and novel bionic tubular material made of polypropylene composite materials, base's periosteum are polypropylene net, are connect
It is collagen to touch periosteum, after the two is compound, does not use cross-linking step.Preparation method is：
1)：It is managed by netted braided fabric is clipped made of nondegradable polypropylene fibre, is sewn into tubulose, and by two
Shape braided fabric is nested together, and then cleans, sterilizes, then after being impregnated with ionic liquid, the referred to as double-deck webmaster；
2)：By Atelocollagen albumen water dissolution, solution is obtained, for use；
3)：Acquired solution in step 2) is injected into cylindrical die, thickness is bigger 3mm than the diameter of the double-deck webmaster；By step
1) for the Double-level Reticulated pipe sleeve on stainless steel bar, the diameter of stainless steel bar is equal to the internal diameter of internal layer webmaster, is then put in mold
Solution in, the double-deck webmaster on the thickness direction of solution be located at centre, impregnate 1h after, take out drying, then further according to bionical
Repair tubular material thickness requirement, be repeated 3 times dipping, drying step；
4) to obtaining final products after drying in step 3), the thickness of tube wall is 0.6mm.
Wherein, in the solution in the step 2) biodegradable material a concentration of 1wt%.
Drying in the step 3) is 25 DEG C of drying.
Polypropylene and the compound double layered tubular material of Atelocollagen albumen are obtained through above step.
The method that the product of above-described embodiment 1-4 and comparative example 1-2 measure is as follows：
The thickness vernier caliper measurement of film measures the thickness of 5 different locations, is averaged conduct to same film
The thickness value of the film.
The expansion rate of film：The thickness measured after ten minutes divided by dry state film are impregnated using dry state film pure water or physiological saline
Thickness, the ratio of gained is expansion rate.
The wet tensile intensity of film is tested using measurer for pulling force, is impregnated with physiological saline to the sample that width is 1cm
It 10 minutes, fully after expansion, is tested.The Fractured cross-sections of power and film when record fracture accumulate, and the ratio of the two is as wet
State tensile strength.
The performance data of the product of embodiment 1-4 and comparative example 1-2 is shown in Table 1.
The product size and performance data table of table 1 embodiment 1-3 and comparative example 1-2
The mechanical strength of comparative example 1 is inadequate, is easy to be sewn line tearing fracture in sewing process, comparative example 2 is in body fluid
Soaking process volume sweell(ing), suture is difficult, while also cannot achieve repairing effect.
The inter-layer bonding force of the composite membrane of comparative example 2 is less than embodiment 1-3, and laboratory technician can be manually the compound of comparative example 2
UF membrane comes, but embodiment 1-4 is difficult to separate.
Claims (11)
1. a kind of bionical tubular material is made of base's periosteum and contact periosteum, wherein base's periosteum is placed in two contact periosteums
Centre, which is characterized in that base's periosteum is made of nondegradable high molecular polymer, contact periosteum by biodegradable material
Material is made, and three-layer pipe film is closely combined with each other, and the surfacing of anti-adhesion biomimetic repair membrane.
2. bionical tubular material as described in claim 1, wherein the nondegradable high molecular polymer is non-degradable
Polyester, polyethylene, polypropylene, one or more in polytetrafluoroethylene (PTFE).
3. bionical tubular material as described in claim 1, wherein the degradable high molecular polymer is degradable saturating
One kind in bright matter acid, collagen, chitosan, polylactic acid, polyglycolide, polydioxanone, polyhydroxyalkanoate
Or it is a variety of.
4. bionical tubular material as claimed in claim 3, wherein the degradable high molecular polymer is the glue for holding peptide
Former albumen.
5. bionical tubular material as described in claim 1, wherein the degradable high molecular polymer is porous structure.
6. bionical tubular material as described in claim 1, wherein contain calcium chloride or iron chloride in the contact membranes.
7. bionical tubular material as described in claim 1, base's periosteum is netted periosteum.
8. bionical tubular material as described in claim 1, thickness 0.01-3mm.
9. a kind of preparation method of such as bionical tubular material of claim 1-8 any one of them, includes the following steps：
1) by netted braided fabric is clipped made of nondegradable macromolecule polymer material, is sewn into tubulose, and by two
Tubular braid is nested together, and then cleans, sterilizes, then after being impregnated with ionic liquid, the referred to as double-deck webmaster；
2) biodegradable material is dissolved with solvent, calcium chloride or iron chloride is added, obtains solution, for use；
3) acquired solution in step 2) is injected into mold, thickness is bigger 2~10mm than the diameter of the double-deck webmaster；It will be double in step 1)
Layer webmaster is sleeved on glass bar, and the diameter of glass bar is equal to the internal diameter of internal layer webmaster, is then put in the solution in mold, double-deck
Webmaster is located at centre on the thickness direction of solution, dipping after a certain period of time, take out and dry, then further according to bionics prosthesis pipe
The thickness requirement of shape material repeats 0-10 dipping, dry step；
4) biodegradable material in the product after drying in step 3) is crosslinked, obtains final products, the thickness of tube wall
Degree is 0.01-3mm.
10. the manufacturing method of bionical tubular material as claimed in claim 9, wherein biological in the solution in the step 2)
A concentration of 0.3wt%~50wt% of degradation material.
11. the manufacturing method of bionical tubular material as claimed in claim 9, wherein the drying in the step 3) is wind
Dry, drying or freeze-drying.
Priority Applications (1)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113616604A (en) * | 2021-10-12 | 2021-11-09 | 北京蓝晶微生物科技有限公司 | Injectable polyhydroxyalkanoate microspheres and preparation method thereof |
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