CN108440421A - A kind of deuterated Sai Lexipa and preparation method thereof - Google Patents
A kind of deuterated Sai Lexipa and preparation method thereof Download PDFInfo
- Publication number
- CN108440421A CN108440421A CN201810455247.0A CN201810455247A CN108440421A CN 108440421 A CN108440421 A CN 108440421A CN 201810455247 A CN201810455247 A CN 201810455247A CN 108440421 A CN108440421 A CN 108440421A
- Authority
- CN
- China
- Prior art keywords
- deuterated
- sai lexipa
- lexipa
- sai
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/16—Halogen atoms; Nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention discloses a kind of deuterated Sai Lexipa d SP
Description
The case where for the prior art, the object of the present invention is to provide a kind of new deuterated Sai Lexipa and its preparation side
Method.
Technical scheme of the present invention：To achieve the above object, the technical scheme is that：
In a first aspect, the invention discloses a kind of intermediate d-SP-1 of deuterated Sai Lexipa, structural formula is as follows：
Second aspect, the invention discloses a kind of preparation method of deuterated Sai Lexipa, synthetic route is as follows：
The preparation method includes the following steps：
Step 1, intermediate d-SP-1 is prepared：Coupling reaction is occurred by compound d-SP-2 and compound Int-2 and obtains d-
SP-1；
Step 2, deuterated Sai Lexipa d-SP are prepared：Occurred in the presence of a base by intermediate d-SP-1 and compound Int-1
Condensation reaction obtains the deuterated Sai Lexipa d-SP of target product.
The catalyst prepared used in intermediate d-SP-1 is selected from tetrakis triphenylphosphine palladium；Solvent used is selected from first
Benzene, ortho-xylene, meta-xylene, paraxylene, Isosorbide-5-Nitrae-dioxane, n,N-Dimethylformamide, n,N-dimethylacetamide,
One kind in dimethyl sulfoxide (DMSO)；Alkali used in sodium carbonate, potassium carbonate, cesium carbonate, sodium hydroxide, potassium hydroxide one
Kind；Reaction temperature used is reflux temperature of the room temperature to solvent；Reaction time used is 2~16 hours.Preferably, it prepares
The one kind of solvent in toluene, dioxane used in intermediate d-SP-1；Alkali used is in sodium carbonate, potassium carbonate
It is a kind of；Reaction temperature used is 80 DEG C~110 DEG C；Reaction time used is 5~8 hours.
The alkali prepared used in deuterated Sai Lexipa d-SP be selected from sodium hydride, lithium hydride, potassium tert-butoxide, potassium carbonate,
One kind in cesium carbonate, 11 carbon -7- alkene of 1,8- diazabicyclos [5.4.0], pyridine, triethylamine, triethylene diamine；Used
Solvent is selected from n,N-Dimethylformamide, n,N-dimethylacetamide, dimethyl sulfoxide (DMSO), N-Methyl pyrrolidone, toluene, neighbour two
One kind in toluene, meta-xylene, paraxylene；Reaction temperature used is reflux temperature of the room temperature to solvent；Used is anti-
It is 4~24 hours between seasonable.Preferably, it prepares the alkali used in deuterated Sai Lexipa d-SP and is selected from sodium hydride, potassium carbonate, 1,8-
One kind in 11 carbon -7- alkene of diazabicyclo [5.4.0]；It is sub- that solvent used is selected from n,N-Dimethylformamide, dimethyl
One kind in sulfone, N-Methyl pyrrolidone, toluene；Reaction temperature used is room temperature to 150 DEG C；Reaction time used is 6
~14 hours.
Beneficial effects of the present invention：The present invention provides a kind of novel deuterated Sai Lexipa, is to the beneficial of the prior art
Supplement；And the preparation method of deuterated Sai Lexipa provided by the invention is to filter out best reaction step by many experiments
Suddenly, specific reaction temperature, the specific process parameters such as time, operability is strong, it can be achieved that commercially produce, per single step reaction
Yield is all very high, and product purity is more than 99%, and total recovery is high, and reachable 90% or more, and D abundance>99%.The present invention is prepared into
To stable isotope labeling Sai Lexipa d-SP can be very good be applied to Clinical pharmacokinetics in terms of research, to
More accurately and easily understand metabolic processes and mechanism of action of the Sai Lexipa in human body, it is with important application prospects.
Way of example
Intermediate compound I nt-1 referenced patents CN105949135 is made.
Embodiment 1
Step 1：Prepare d-SP-1
Compound d-SP-2 (2.69g, 10mmol) is added in toluene (30ml), add sodium carbonate (2.54g,
24mmol), Int-2 (2.54g, 20mmol), tetrakis triphenylphosphine palladium (0.1g) and water (5ml) open stirring, are heated to 100
DEG C reaction 6 hours, the reaction was complete for the board monitoring of TLC points, is cooled to room temperature, and water is added, and stirs 10min, stratification discards water
Layer, organic phase are dried with anhydrous sodium sulfate, and concentration removes most of solvent, and solid, filtering is precipitated, and filter cake is washed with ether, obtained
To light yellow solid d-SP-1 (2.29g, yield 83%).
ESI/MS：M/z=277 (M+H)+.
1HNMR(400MHz,DMSO-D6)：δppm8.65(s,1H).
Step 2：Prepare deuterated Sai Lexipa d-SP
By compound d-SP-1 (2.2g, 7.97mmol), 1,8- diazabicyclos [5.4.0], 11 carbon -7- alkene (1.24g,
8.12mmol), Int-1 (2.33g, 8.77mmol) is added in N-Methyl pyrrolidone (50ml), is opened stirring, is heated to
140 DEG C are reacted 8 hours, and the reaction was complete for the board monitoring of TLC points, distills partial solvent, and residue pours into mixture of ice and water, are precipitated
Solid, filtering, filter cake are crystallized with absolute ethyl alcohol, obtain the deuterated Sai Lexipa d-SP of white solid (3.59g, yield 89%).
ESI/MS：M/z=507 (M+H)+.
1H NMR(400MHz,DMSO-D6)：δ ppm8.46 (s, 1H), 8.11 (s, 1H), 4.25 (s, 2H), 3.30 (t,
2H), 3.04(t,2H),2.96(m,1H),1.52-1.49(m,4H),1.04(d,6H)。
Embodiment 2
Step 1：Prepare d-SP-2
Compound d-SP-2 ' (2.69g, 10mmol) is added to CF3CO2D (30ml) and D2The mixed solvent of O (20ml)
In, tube sealing reaction is carried out, 150 DEG C is heated to and reacts 36 hours, be cooled to room temperature, concentration removes solvent, obtains gray solid d-
SP-2 is directly used in react in next step.
ESI/MS：M/z=272 (M+H)+.
Step 2：Prepare d-SP-1
Compound d-SP-2 (2.72g, 10mmol) is added in toluene (30ml), add sodium carbonate (2.54g,
24mmol), Int-2 (2.54g, 20mmol), tetrakis triphenylphosphine palladium (0.1g) and water (5ml) open stirring, are heated to 100
DEG C reaction 6 hours, the reaction was complete for the board monitoring of TLC points, is cooled to room temperature, and water is added, and stirs 10min, stratification discards water
Layer, organic phase are dried with anhydrous sodium sulfate, and concentration removes most of solvent, and solid, filtering is precipitated, and filter cake is washed with ether, obtained
To light yellow solid d-SP-1 (2.29g, yield 83%).
ESI/MS：M/z=277 (M+H)+
13C NMR(400MHz,DMSO-D6)：δppm 154.1,153.8,144.7,143.2,138.4,128.2,
127.6, 127.1。
Step 3：Prepare deuterated Sai Lexipa d-SP
By compound d-SP-1 (2.0g, 7.2mmol), 1,8- diazabicyclos [5.4.0], 11 carbon -7- alkene (1.22g,
8mmol), Int-1 (2.1g, 7.92mmol) is added in N-Methyl pyrrolidone (45ml), is opened stirring, is heated to 140 DEG C
Reaction 10 hours, the reaction was complete for the board monitoring of TLC points, distills partial solvent, and residue pours into mixture of ice and water, is precipitated solid
Body, filtering, filter cake are crystallized with absolute ethyl alcohol, obtain the deuterated Sai Lexipa d-SP of white solid (3.17g, yield 87%).
ESI/MS：M/z=508 (M+H)+.
1H NMR(400MHz,DMSO-D6)：δ ppm8.10 (s, 1H), 4.24 (s, 2H), 3.30 (t, 2H), 3.03 (t,
2H), 2.95(m,1H),1.53-1.51(m,4H),1.06(d,6H)。
Claims (5)
1. a kind of deuterated Sai Lexipa d-SP, which is characterized in that structural formula is as follows：
Wherein, R1~R6 is part D-atom or whole D-atoms.
2. a kind of deuterated Sai Lexipa d-SP according to claim 1, which is characterized in that a kind of centre of deuterated Sai Lexipa
The structural formula of body d-SP-1 is as follows：
3. the preparation method of deuterated Sai Lexipa according to claim 1, a kind of, which is characterized in that synthetic route is as follows
It is shown：
It comprises the following steps：
Step 1, intermediate d-SP-1 is prepared：Coupling reaction is occurred by compound d-SP-2 and compound Int-2 and obtains d-SP-1；
Step 2, deuterated Sai Lexipa d-SP are prepared：It is condensed in the presence of a base by intermediate d-SP-1 and compound Int-1
The deuterated Sai Lexipa d-SP of target product are obtained by the reaction.
4. the preparation method of deuterated Sai Lexipa according to claim 3, a kind of, which is characterized in that in the preparation
Catalyst used in mesosome d-SP-1 is selected from tetrakis triphenylphosphine palladium；Solvent used is selected from toluene, ortho-xylene, diformazan
One in benzene, paraxylene, Isosorbide-5-Nitrae-dioxane, n,N-Dimethylformamide, n,N-dimethylacetamide, dimethyl sulfoxide (DMSO)
Kind；The one kind of alkali used in sodium carbonate, potassium carbonate, cesium carbonate, sodium hydroxide, potassium hydroxide；Reaction temperature used
For the reflux temperature of room temperature to solvent；Reaction time used is 2~16 hours.
5. the preparation method of deuterated Sai Lexipa according to claim 3, a kind of, which is characterized in that described prepares deuterium
Alkali used in Dai Sailexipa d-SP is selected from sodium hydride, lithium hydride, potassium tert-butoxide, potassium carbonate, cesium carbonate, 1,8- diazabicyclos
One kind in [5.4.0] 11 carbon -7- alkene, pyridine, triethylamine, triethylene diamine；Solvent used is selected from N, N- dimethyl methyls
Amide, n,N-dimethylacetamide, dimethyl sulfoxide (DMSO), N-Methyl pyrrolidone, toluene, ortho-xylene, meta-xylene, to diformazan
One kind in benzene；Reaction temperature used is reflux temperature of the room temperature to solvent；Reaction time used is 4~24 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810455247.0A CN108440421A (en) | 2018-05-14 | 2018-05-14 | A kind of deuterated Sai Lexipa and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810455247.0A CN108440421A (en) | 2018-05-14 | 2018-05-14 | A kind of deuterated Sai Lexipa and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108440421A true CN108440421A (en) | 2018-08-24 |
Family
ID=63203286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810455247.0A Withdrawn CN108440421A (en) | 2018-05-14 | 2018-05-14 | A kind of deuterated Sai Lexipa and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108440421A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011017612A1 (en) * | 2009-08-06 | 2011-02-10 | Concert Pharmaceuticals, Inc. | Substituted diphenylpyrazine derivatives |
| CN105085516A (en) * | 2015-06-02 | 2015-11-25 | 吉林奥来德光电材料股份有限公司 | Aromatic heterocyclic derivative and preparation method therefore as well as organic electroluminescent device |
| CN105949135A (en) * | 2016-05-10 | 2016-09-21 | 湖南欧亚生物有限公司 | Synthetic method of selexipag |
-
2018
- 2018-05-14 CN CN201810455247.0A patent/CN108440421A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011017612A1 (en) * | 2009-08-06 | 2011-02-10 | Concert Pharmaceuticals, Inc. | Substituted diphenylpyrazine derivatives |
| CN105085516A (en) * | 2015-06-02 | 2015-11-25 | 吉林奥来德光电材料股份有限公司 | Aromatic heterocyclic derivative and preparation method therefore as well as organic electroluminescent device |
| CN105949135A (en) * | 2016-05-10 | 2016-09-21 | 湖南欧亚生物有限公司 | Synthetic method of selexipag |
Non-Patent Citations (1)
| Title |
|---|
| 王世真: "《分子核医学（第二版）》", 30 April 2004, 中国协和医科大学出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUE026821T2 (en) | Process for the preparation of 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-n-methylpyridine-2-carboxamide, its salts and monohydrate | |
| CN111793101B (en) | Process for the synthesis of C-nucleoside compounds | |
| TW201209046A (en) | Method for producing a methylene disulfonate compound | |
| CN108285438B (en) | Synthesis process of benzyl ribose lactone | |
| CN104447620B (en) | 1-[3-[3-(4-chlorphenyl) propoxyl group] propyl group] preparation method of-piperidine hydrochlorate | |
| CN111032617B (en) | Process for preparing 4- (heptafluoro-2-propyl) aniline | |
| CN111333543B (en) | Synthesis method of rilpivirine intermediate | |
| CN104311485B (en) | A kind of preparation method treating leukemic medicine bosutinib | |
| CN108440421A (en) | A kind of deuterated Sai Lexipa and preparation method thereof | |
| IT201800000667A1 (en) | PROCEDURE FOR THE PREPARATION OF DISPLACED DIARYLOXYHETERODIAZOLIC COMPOUNDS | |
| Ma et al. | Synthesis, structure, and conformation of ortho-linked oxacalix [n] arene [n] hetarenes | |
| Umemura et al. | Synthesis of a Fragment A Derivative of an Antibiotic, Nosiheptide. | |
| BR112019017556A2 (en) | process for the preparation of 2-cyanoimidazole compounds | |
| CN111116553B (en) | Preparation method of dihydropyridone derivatives | |
| CN104447521B (en) | Reagent for preparing high-selectivity monofluoroolefin | |
| CN107721917B (en) | Green synthesis method of polysubstituted nicotinate compound | |
| CN107021968B (en) | The method of the polysubstituted organic photochemical catalyst catalyzing indole quinoline class compound oxidation dehydrogenation synthesis of indole class compound of BODIPY | |
| CN107074678A (en) | The manufacture method of fullerene derivate | |
| KR100496248B1 (en) | Process for preparation of sulfonamide derivatives and crystals thereof | |
| CN112574133B (en) | Synthesis method of 1, 3-diaryl substituted tetrazolone inner salt | |
| Jin et al. | A contribution to the study of the modified Marschalk reaction: Hydroxymethylation of 6, 8-O-dimethyl emodin | |
| CN114591326B (en) | Intermediate of CCT-251921 and preparation method thereof | |
| CN114315637B (en) | Preparation method of carboxyamidotriazole and carboxyamidotriazole intermediate | |
| TWI833610B (en) | Method and intermediates for preparing tricyclic compounds | |
| CN108129357B (en) | Preparation method of anamorelin intermediate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180824 |