CN108432743B - Portable organ donation donor mechanical perfusion system - Google Patents
Portable organ donation donor mechanical perfusion system Download PDFInfo
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- CN108432743B CN108432743B CN201810623202.XA CN201810623202A CN108432743B CN 108432743 B CN108432743 B CN 108432743B CN 201810623202 A CN201810623202 A CN 201810623202A CN 108432743 B CN108432743 B CN 108432743B
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
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Abstract
The invention discloses a portable organ donation donor mechanical perfusion system, which comprises a blood circulation oxygenation closing device and a control device electrically connected with the blood circulation oxygenation closing device, wherein the blood circulation oxygenation closing device comprises an oxygenator, a centrifugal pump, a blood displacer, an arterial cannula and a venous cannula, a piston capable of moving up and down is arranged in the blood displacer, the upper part of the piston is a first storage end for storing donor blood, the lower part of the piston is a second storage end for storing perfusate, the blood input end and the output end of the centrifugal pump are communicated with the first storage end through a first three-way valve, and the blood input end and the output end of the centrifugal pump are communicated with the second storage end through a second three-way valve, so that low-temperature perfusion can be completed without re-intubation of abdominal aorta after reopening. Moreover, as the balloon is arranged at the head end of the arterial cannula, when only the abdominal organ is perfused, only the balloon is inflated or injected with water, so that the arterial cannula is more convenient.
Description
Technical Field
The invention relates to the technical field of medical appliances, in particular to a portable organ donation donor mechanical perfusion system.
Background
Organ transplantation is the only treatment scheme for patients with end-stage organ diseases, but the lack of donor organs severely restricts organ transplantation treatment, and with the advancement of China and further deepening of the innovation of the organ transplantation field, the donation of organs by citizens is a main way of donor organ sources in China.
The organ donation by citizens in China can be classified into three types, namely brain death (DBD), heart death (DCD) and brain heart double death (DBCD), wherein the DCD and the DBCD donor organs inevitably undergo thermal ischemia injury caused by hypotension, shock, cardiac arrest and the like before being obtained, thereby seriously affecting the quality of the organs and finally endangering the safety of transplant recipients. In order to alleviate or avoid thermal ischemia injury in organ transplantation, the method adopted at present is as follows: donor organs are perfused at normal temperature by using an extracorporeal membrane oxygenation (ECMO) device, ECMO perfusion is stopped when the organs are obtained, then the abdominal aorta and the portal vein are cannulated by an open-abdominal operation, a low-temperature organ preservation solution is perfused, and the organs are obtained in a low-temperature perfusion process.
ECMO-supported donor organ harvesting suffers from the following drawbacks: (1) Perfusion of the whole body of blood distribution, the inability to do perfusion is only for abdominal organs; (2) The normal temperature blood can not be converted into the low temperature organ preservation solution in good time in the perfusion process; (3) The perfusion process cannot rapidly reduce the temperature of the donor organ as required; (4) ECMO equipment is complicated, and the volume is great, carries inconveniently.
Disclosure of Invention
The invention aims to solve the technical problem of providing a portable organ donation donor mechanical perfusion system which not only can support normal temperature blood circulation of an organ donation donor, but also can perform normal temperature blood perfusion or low temperature organ preservation solution perfusion on the donation organ at proper time according to the needs, and particularly can perfuse the donation organ at low temperature and rapidly reduce the temperature of the donation organ without an open operation.
In order to solve the problems, the invention adopts the following technical scheme:
the portable organ donation donor mechanical perfusion system comprises a blood circulation oxygenation closing device and a control device electrically connected with the blood circulation oxygenation closing device. The blood circulation occlusion device comprises an oxygenator, a centrifugal pump, a blood displacer, an arterial cannula and a venous cannula, wherein:
the oxygenator is provided with a first input end used for being connected with an oxygen source, a first output end used for discharging carbon dioxide, a blood input end used for being connected with the output end of the centrifugal pump and a blood output end used for being connected with the arterial cannula;
the input end of the centrifugal pump is communicated with the venous cannula;
the blood displacer is characterized in that a piston capable of moving up and down is arranged in the blood displacer, the upper part of the piston is a first storage end for storing donor blood, the lower part of the piston is a second storage end for storing perfusate, the blood input end and the centrifugal pump output end are communicated with the first storage end through a first three-way valve, and the blood input end and the centrifugal pump output end are communicated with the second storage end through a second three-way valve.
Further, a balloon is arranged at the head end of the arterial cannula.
Further, a variable-temperature water tank with a refrigerating part is detachably connected in the control device, and a second input end used for being connected with the water outlet end of the variable-temperature water tank and a second output end used for being connected with the water inlet end of the variable-temperature water tank are further arranged on the oxygenator.
Still further, the cooling member is made of a semiconductor material.
Preferably, the arterial catheter further comprises an arterial pressure sensor and a venous pressure sensor, one end of the arterial pressure sensor is electrically connected with the control device, and the other end of the arterial pressure sensor is connected to a pipeline between the blood output end and the arterial cannula through a third three-way valve; one end of the venous pressure sensor is electrically connected with the control device, and the other end of the venous pressure sensor is connected to a pipeline between the input end of the centrifugal pump and the venous cannula through a fourth three-way valve.
Preferably, the device further comprises an oxygen saturation sensor, one end of the oxygen saturation sensor is electrically connected with the control device, and the other end of the oxygen saturation sensor is connected to a pipeline between the input end of the centrifugal pump and the venous cannula through a fifth three-way valve.
Preferably, the device further comprises a flow sensor, one end of the flow sensor is electrically connected with the control device, and the other end of the flow sensor is connected to a pipeline between the output end of the centrifugal pump and the blood input end.
Preferably, the temperature control device further comprises a temperature sensor, one end of the temperature sensor is electrically connected with the control device, and the other end of the temperature sensor is connected to a pipeline between the first input end and the water outlet end of the variable-temperature water tank.
Preferably, a thrombus filter device is arranged on the pipeline between the blood input end and the first three-way valve.
Compared with the prior art, the invention has the following beneficial effects:
(1) Because the blood input end and the centrifugal pump output end are communicated with the first storage end through the first three-way valve, the blood input end and the centrifugal pump output end are communicated with the second storage end through the second three-way valve, when low-temperature perfusion is needed, the pipeline between the first three-way valve and the blood input end is closed, then the centrifugal pump starts to work, blood in an organ is led out into the first storage end and pushes the piston to move downwards, at the moment, perfusate in the second storage end can enter the oxygenator to be combined with oxygen, meanwhile, the control device controls the refrigerating piece of the variable-temperature water tank to start working, so that the temperature of water which flows into the oxygenator from the variable-temperature water tank and is subjected to heat exchange with the perfusate combined with oxygen is 4 ℃, and finally the low-temperature perfusate combined with oxygen can sequentially flow through the blood output end and the artery cannula and then enter a human body, therefore, the donor mechanical perfusion system can complete low-temperature perfusion without opening an abdomen.
(2) Because the saccule is arranged at the head of the artery cannula, when only the abdominal organs and organs below are perfused, the head end of the artery cannula is only required to be placed above the abdominal aortic trunk, and then the abdominal aorta above the abdominal arterial trunk can be blocked by inflating or injecting water into the saccule, so that the method is more convenient.
(3) Because the temperature-changing water tank is internally provided with the refrigerating piece, in the process of filling, the control device controls the refrigerating piece to work, so that the water temperature of water flowing out of the temperature-changing water tank and flowing into the oxygenator for heat exchange with the storage liquid is quickly reduced to 4 ℃, and the donor organ is quickly reduced to 4 ℃.
(4) Because the variable-temperature water tank is arranged inside the control device, the volume of the mechanical perfusion system of the portable organ donation donor is greatly saved, and the carrying convenience is further improved.
The foregoing description is only an overview of the present invention, and is intended to provide a better understanding of the technical means of the present invention, and is to be implemented in accordance with the contents of the specification, as well as to provide a better understanding of the above and other objects, features and advantages of the present invention, and the following detailed description of the preferred embodiments, taken in conjunction with the accompanying drawings.
Drawings
FIG. 1 is a schematic diagram of a portable organ donor mechanical perfusion system according to the present invention;
wherein reference numerals in fig. 1 are explained as follows:
1. a control device; 2. an oxygenator; 3. a centrifugal pump; 4. a blood displacer; 5. arterial cannulation; 6. intravenous cannula; 7. an oxygen source; 8. a piston; 9. a first three-way valve; 10. a second three-way valve; 11. a water outlet end; 12. a water inlet end; 13. an arterial pressure sensor; 14. a venous pressure sensor; 15. a third three-way valve; 16. a fourth three-way valve; 17. a blood oxygen saturation sensor; 18. a fifth three-way valve; 19. a flow sensor; 20. a temperature sensor; 21. a display screen; 22. a bracket; 23. a hook.
Detailed Description
In order to further describe the technical means adopted by the invention to achieve the expected aim of the invention, the following detailed description is given of the specific implementation, structure and characteristics according to the invention by combining the accompanying drawings and the preferred embodiments:
as shown in fig. 1, the portable organ donor mechanical perfusion system of the present invention comprises a blood circulation oxygenation closing device and a control device 1 electrically connected to the blood circulation oxygenation closing device, and the blood circulation oxygenation closing device comprises an oxygenator 2, a centrifugal pump 3, a blood displacer 4, an arterial cannula 5 and a venous cannula 6, wherein:
the oxygenator 2 is provided with a first input for connection to an oxygen source 7, a first output for discharging carbon dioxide, a blood input for connection to the output of the centrifugal pump 3, and a blood output for connection to the arterial cannula 5;
the input end of the centrifugal pump 3 is communicated with the venous cannula 6;
the blood displacer 4 is internally provided with a piston 8 capable of moving up and down, the upper part of the piston 8 is a first storage end for storing donor blood, the lower part of the piston 8 is a second storage end for storing perfusate, the blood input end and the output end of the centrifugal pump 3 are communicated with the first storage end through a first three-way valve 9, and the blood input end and the output end of the centrifugal pump 3 are communicated with the second storage end through a second three-way valve 10.
When the organ needs to be perfused, the pipeline between the first three-way valve 9 and the blood input end is closed firstly, then the centrifugal pump 3 starts to work, the input port of the centrifugal pump 3 generates negative pressure, blood in the organ is led out to the first storage end through the venous cannula 6, after the blood volume in the first storage end is increased, the pressure in the first storage end is increased and the piston 8 is pushed to move downwards, at the moment, perfusate stored in the second storage end can enter the oxygenator 2 to be combined with oxygen, meanwhile, the control device 1 controls the refrigerating piece in the variable-temperature water tank to start to work, so that the water temperature of water flowing into the oxygenator 2 from the variable-temperature water tank to be subjected to heat exchange with perfusate is rapidly reduced to 4 ℃, and finally, the low-temperature perfusate combined with oxygen can sequentially enter a human body through the blood output end and the arterial cannula 5, and after the whole blood in the organ is replaced by the perfusate, the perfusion is completed, so that the temperature of the organ is rapidly reduced, and the donor is not required to be perfused in a portable abdomen donor system after the donor is opened, and the donor is not required to be perfused.
The head end of the artery cannula 5 is provided with a saccule, when only the abdominal organs and organs below are perfused, the head end of the artery cannula 5 is only required to be placed above the abdominal aortic trunk, and the abdominal aorta above the abdominal arterial trunk can be blocked by inflating or injecting water into the saccule, so that the method is more convenient.
The control device 1 is internally and detachably connected with a variable-temperature water tank with a refrigerating part, and the oxygenator 2 is also provided with a second input end used for being connected with a water outlet end 11 of the variable-temperature water tank and a second output end used for being connected with a water inlet end 12 of the variable-temperature water tank. Because the temperature-changing water tank is internally provided with the refrigerating piece, the temperature of water flowing into the oxygenator 2 from the temperature-changing water tank and performing heat exchange with perfusate can be quickly reduced to 4 ℃ by controlling the working of the refrigerating piece through the control device 1 in the perfusion process, so that the temperature of the perfused organ is quickly reduced.
As a modification of this embodiment, the refrigerating element is made of a semiconductor material.
The portable organ donation donor mechanical perfusion system further comprises an arterial pressure sensor 13 and a venous pressure sensor 14, wherein one end of the arterial pressure sensor 13 is electrically connected with the control device 1, and the other end of the arterial pressure sensor 13 is connected to a pipeline between the blood output end and the arterial cannula 5 through a third three-way valve 15; one end of the venous pressure sensor 14 is electrically connected with the control device 1, and the other end of the venous pressure sensor 14 is connected to a pipeline between the input end of the centrifugal pump 3 and the venous cannula 6 through a fourth three-way valve 16.
When in specific connection, a first interface and a second interface for respectively and electrically connecting the arterial pressure sensor 13 and the venous pressure sensor 14 are arranged on the shell of the control device 1.
In order to monitor the blood oxygen saturation in real time, the portable organ donation donor mechanical perfusion system further comprises a blood oxygen saturation sensor 17, wherein one end of the blood oxygen saturation sensor 17 is electrically connected with the control device 1, and the other end of the blood oxygen saturation sensor is connected to a pipeline between the input end of the centrifugal pump 3 and the venous cannula 6 through a fifth three-way valve 18.
When in specific connection, a third interface for electrically connecting the blood oxygen saturation sensor is arranged on the shell of the control device 1.
The portable organ donation donor mechanical perfusion system further comprises a flow sensor 19, one end of the flow sensor 19 is electrically connected with the control device 1, and the other end of the flow sensor 19 is connected to a pipeline between the output end of the centrifugal pump 3 and the blood input end.
When in specific connection, a fourth interface for electrically connecting the flow controller is arranged on the shell of the control device 1.
The portable organ donation donor mechanical perfusion system further comprises a temperature sensor 20, one end of the temperature sensor 20 is electrically connected with the control device 1, and the other end of the temperature sensor 20 is connected to a pipeline of the first input end and the outlet end 11 of the variable-temperature water tank.
In a specific connection, a fifth interface for electrically connecting the temperature sensor 20 is disposed on the housing of the control device 1.
In addition, a micro-plug filter is arranged on the pipeline between the blood input end and the first three-way valve 9, and the micro-plug filter is used for filtering micro-plugs in venous blood.
In order to accurately understand various monitoring results in the process of perfusion, a display screen 21 is arranged on the shell of the control device 1, and the display screen 21 is used for displaying monitoring data of the flow sensor 19, the temperature sensor 20, the blood oxygen saturation sensor 17, the venous pressure sensor 14 and the arterial pressure sensor 13.
In order to facilitate the installation and use of the blood circulation oxygenation closing device, the portable organ donor mechanical perfusion system further comprises a support 22, a hook 23 for hanging the blood circulation oxygenation closing device is arranged at the top end of the support 22, and when the portable organ donor mechanical perfusion system is particularly used, the centrifugal pump 3 and the oxygenator 2 are detachably connected to the lower end of the support 22.
It should be noted that in the description of the present invention, the terms "first," "second," "third," "fourth," "fifth," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
The above embodiments are only preferred embodiments of the present invention, and the scope of the present invention is not limited thereto, but any insubstantial changes and substitutions made by those skilled in the art on the basis of the present invention are intended to be within the scope of the present invention as claimed.
Claims (9)
1. The utility model provides a portable organ donation donor mechanical perfusion system, includes blood circulation oxygenation closing device and with blood circulation oxygenation closing device electric connection's controlling means to blood circulation oxygenation closing device includes oxygenator, centrifugal pump, blood displacer, arterial cannula and venous cannula, its characterized in that: the oxygenator is provided with a first input end used for being connected with an oxygen source, a first output end used for discharging carbon dioxide, a blood input end used for being connected with the output end of the centrifugal pump and a blood output end used for being connected with the arterial cannula; the input end of the centrifugal pump is communicated with the venous cannula; a piston capable of moving up and down is arranged in the blood displacer, the upper part of the piston is a first storage end for storing donor blood, the lower part of the piston is a second storage end for storing perfusate, the blood input end and the output end of the centrifugal pump are communicated with the first storage end through a first three-way valve, and the blood input end and the output end of the centrifugal pump are communicated with the second storage end through a second three-way valve;
the control device is internally and detachably connected with a variable-temperature water tank with a refrigerating part, and the oxygenator is also provided with a second input end used for being connected with the water outlet end of the variable-temperature water tank and a second output end used for being connected with the water inlet end of the variable-temperature water tank.
2. The portable organ donor mechanical perfusion system of claim 1, wherein: the head end of the arterial cannula is provided with a saccule.
3. The portable organ donor mechanical perfusion system of claim 1, wherein: the cooling member is made of a semiconductor material.
4. The portable organ donor mechanical perfusion system of claim 1, wherein: the arterial pressure sensor is electrically connected with the control device, and the other end of the arterial pressure sensor is connected to a pipeline between the blood output end and the arterial cannula through a third three-way valve; one end of the venous pressure sensor is electrically connected with the control device, and the other end of the venous pressure sensor is connected to a pipeline between the input end of the centrifugal pump and the venous cannula through a fourth three-way valve.
5. The portable organ donor mechanical perfusion system of claim 1, wherein: the blood oxygen saturation device is characterized by further comprising a blood oxygen saturation sensor, one end of the blood oxygen saturation sensor is electrically connected with the control device, and the other end of the blood oxygen saturation sensor is connected to a pipeline between the input end of the centrifugal pump and the venous cannula through a fifth three-way valve.
6. The portable organ donor mechanical perfusion system of claim 1, wherein: the centrifugal pump further comprises a flow sensor, one end of the flow sensor is electrically connected with the control device, and the other end of the flow sensor is connected to a pipeline between the output end of the centrifugal pump and the blood input end.
7. The portable organ donor mechanical perfusion system of claim 1, wherein: the temperature sensor is electrically connected with the control device at one end, and the other end of the temperature sensor is connected with the first input end and the pipeline of the water outlet end of the variable-temperature water tank.
8. The portable organ donor mechanical perfusion system of claim 1, wherein: a thrombus filtering device is arranged on the pipeline between the blood input end and the first three-way valve.
9. The portable organ donor mechanical perfusion system of claim 1, wherein: the portable organ donation donor mechanical perfusion system further comprises a bracket, wherein the top end of the bracket is provided with a hook for hanging the blood circulation epoxy closing device.
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| CN201810623202.XA CN108432743B (en) | 2018-06-15 | 2018-06-15 | Portable organ donation donor mechanical perfusion system |
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| CN201810623202.XA CN108432743B (en) | 2018-06-15 | 2018-06-15 | Portable organ donation donor mechanical perfusion system |
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| CN108432743B true CN108432743B (en) | 2023-08-11 |
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| CN110432260A (en) * | 2019-03-22 | 2019-11-12 | 天一阁医疗科技(广州)有限公司 | A kind of machine perfusion save set of organism organ |
| CN211294426U (en) * | 2019-03-22 | 2020-08-18 | 天一阁医疗科技(广州)有限公司 | Organ perfusion teaching and training system |
| CN112006016A (en) * | 2019-05-31 | 2020-12-01 | 西安赛德欧医疗研究院有限公司 | Normal temperature oxygenation perfusion apparatus |
| CN110538353A (en) * | 2019-08-19 | 2019-12-06 | 江苏赛腾医疗科技有限公司 | In vitro heart lung support auxiliary system |
| CN113396898B (en) * | 2021-08-02 | 2021-11-09 | 中山大学附属第一医院 | Organ perfusion device and method without interrupting blood flow |
| CN113813454B (en) * | 2021-08-30 | 2022-09-09 | 四川大学华西医院 | Method for collecting blood of organ donation donor |
| CN114470377A (en) * | 2022-02-10 | 2022-05-13 | 天津汇康医用设备有限公司 | Intelligent ECMO treatment device and control method of system based on rolling blood pump |
| CN116235846B (en) * | 2023-02-27 | 2024-01-30 | 中国科学院苏州生物医学工程技术研究所 | Organ perfusion control method, system and device |
| CN117547672B (en) * | 2024-01-02 | 2024-04-05 | 中山大学附属第一医院 | DCD-based in-vitro abdominal viscera perfusion and transplantation system |
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