CN108424841B - Molecular detection laboratory is with supplementary pipe apparatus of opening - Google Patents

Molecular detection laboratory is with supplementary pipe apparatus of opening Download PDF

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Publication number
CN108424841B
CN108424841B CN201810227741.1A CN201810227741A CN108424841B CN 108424841 B CN108424841 B CN 108424841B CN 201810227741 A CN201810227741 A CN 201810227741A CN 108424841 B CN108424841 B CN 108424841B
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tube
opening
pcr
pcr tube
protrusion
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CN108424841A (en
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李朋
邓涛
王国青
朱修篁
张鲁军
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Beijing Capitalbio Medlab Co ltd
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Beijing Capitalbio Medlab Co ltd
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]

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Abstract

An auxiliary tube opening instrument for a molecular detection laboratory comprises a PCR tube base and a tube opening part; the PCR tube is characterized in that the tube opening part is arranged above the base of the PCR tube, the tube opening part can rotate along one side of the PCR tube, and the base of the PCR tube is provided with a PCR tube hole; the opening tube part comprises a rotating part connected with the PCR tube, an opening protrusion corresponding to the projection of the tube cap of the PCR tube, and a connecting section which connects the rotating part with the opening protrusion and does not influence the placement of the PCR tube; the rotating part and the opening protrusion are arranged at two positions opposite to the PCR base; the opening handle extends backwards after the opening protrusion; the position of the opening protrusion corresponds to the protrusion of the PCR tube cap. 4-6 PCR tube parts and open tube parts which are connected with each other are arranged; the arrangement can realize the problem of starting a plurality of PCR tubes at one time; in addition, the anti-tube sliding-out structure is arranged, so that the opening efficiency can be effectively increased. In this way, by rotating the opening handle upwards, the PCR tube cap is driven by the opening protrusion to protrude upwards to open the tube cap. The pipe opening instrument has the advantages of reasonable structure, simple operation and good use and popularization values.

Description

Molecular detection laboratory is with supplementary pipe apparatus of opening
Technical Field
The invention belongs to an auxiliary instrument for a medical or biological inspection department, in particular relates to an auxiliary instrument for a PCR tube, and particularly relates to an auxiliary tube opening instrument for a molecular detection laboratory.
Background
The PCR polymerase chain reaction is a molecular biology technique for amplifying and amplifying specific DNA fragments, which can be regarded as special DNA replication in vitro, and the biggest characteristic of PCR is that trace amount of DNA can be greatly increased. Therefore, even if only a single spot of DNA can be isolated from the hairs, skin or blood left by the murder in the murder case, or the remains of the historic creatures and the historical characters in the fossil, the DNA can be amplified by PCR and compared. This is also the strength of the "micro evidence". The inventors first proposed a method of PCR in 1983, and invented the polymerase chain reaction, i.e., the simple DNA amplification method, in 1985, which means that the PCR technique is truly born. By now 2013, PCR has evolved to a third generation technology. In 1973, Taiwan scientist Qianjin discovered stable Taq DNA polymerase, which also made a fundamental contribution to the development of PCR technology.
At present, a biological or medical laboratory often utilizes PCR to verify genetic materials, particularly in biological and medical inspection related mechanisms, the PCR is very frequently applied, at present, domestic related mechanisms mostly manually open PCR tubes, aiming at some mechanisms with a large number of PCR, workers need to frequently open the PCR tubes, at present, PCR tubes are mostly 200 mu L small tubes, the PCR tubes need to be opened by operators carefully when being opened, and the frequent opening causes hand fatigue due to small opening protrusions and large force; or some operators utilize table corners and the like to open, so that certain pollution is easily caused, the problems that the internal liquid is shaken and splashed and the like are easily caused, and the problem of tube opening of the PCR tube is solved by using no good instrument at present. There is therefore a need for an apparatus that solves the above mentioned technical problems and is simple and convenient to operate.
Aiming at the problems that the PCR tube opening mode in the prior art is easy to cause operator fatigue or the operation process is easy to cause liquid pollution or splashing and the like, the invention designs the auxiliary tube opening instrument for the molecular detection laboratory.
Disclosure of Invention
In order to solve the problems that the PCR tube opening mode in the prior art is easy to cause operator fatigue or the operation process is easy to cause liquid pollution or splashing and the like, the invention provides an auxiliary tube opening instrument for a molecular detection laboratory.
An auxiliary tube opening instrument for a molecular detection laboratory comprises a PCR tube base and a tube opening part; the PCR tube is characterized in that the tube opening part is arranged above the base of the PCR tube, the tube opening part can rotate along one side of the PCR tube, and the base of the PCR tube is provided with a PCR tube hole; the opening tube part comprises a rotating part connected with the PCR tube, an opening protrusion corresponding to the projection of the tube cap of the PCR tube, and a connecting section which connects the rotating part with the opening protrusion and does not influence the placement of the PCR tube; the rotating part and the opening protrusion are arranged at two positions opposite to the PCR base; the opening projection extends backwards to form an opening handle; the position of the opening protrusion corresponds to the protrusion of the PCR tube cap. In this way, by rotating the opening handle upwards, the PCR tube cap is driven by the opening protrusion to protrude upwards to open the tube cap.
Furthermore, the shape of the opening protrusion is consistent with that of the PCR tube cap, so that the method is convenient and better, and the opening is smoother.
Furthermore, two positioning protrusions with the same shape as the opening protrusion are arranged on the outer edges of two sides of the opening protrusion on the base of the PCR tube, and the two positioning protrusions form placing notches for placing the PCR tube cap in a protruding mode. The arrangement can ensure the accurate positioning and placement of the PCR tube during use and the deviation of the placement position.
Further, the rotation part can be set to any structure capable of realizing the rotation of the tube opening part, wherein the rotation part preferably comprises a cylindrical rotating ring arranged on the PCR base and a cylindrical rotating shaft inserted into the cylindrical rotating ring, the length of the cylindrical rotating shaft is longer than that of the cylindrical rotating ring, and a connecting section is arranged on the part of the cylindrical rotating shaft extending out of the cylindrical rotating ring. Or the length of the cylindrical rotating shaft is equal to that of the cylindrical rotating ring, 2 notches are formed in the cylindrical rotating ring, and the connecting section is connected with the cylindrical rotating shaft through the notches.
Furthermore, the connecting section is arranged on the outer edge of the PCR tube hole, the shape of the connecting section is similar to that of the outer edge, and the size of the connecting section is larger than that of the tube hole; the other side of the connecting section is gathered at the opening projection. The arrangement can effectively place the PCR tube and prevent interference.
Furthermore, a tube slipping-out preventing structure is also arranged on the side wall of the PCR tube base; the pipe slipping-out preventing structure can be any structure capable of preventing the pipe from slipping out in the pipe opening process.
Preferably, the tube slipping-out preventing structure comprises a through hole arranged on the side wall of the PCR tube base and an extensible column arranged in the through hole; a pressing cap is arranged at the rear end of the extendable column. Furthermore, the tube slipping-out preventing structure also comprises a transverse spring, one end of the transverse spring is connected with the pressing cap, and the other end of the transverse spring is connected with the side wall of the PCR tube base; the extendable post extends into the transverse spring. The setting can effectively ensure the control of the PCR tube when the tube is opened, and prevent the separation of the PCR tube when the tube is opened and influence the tube opening effect.
Or the tube slipping-out preventing structure comprises an extending hole extending into the hole of the PCR tube, and an extending rod is arranged in the extending hole; the extension rod is provided with a gear structure with a larger diameter, and one side of the gear structure protrudes out of the extension hole; a longitudinal deep groove is arranged on the base part of the PCR tube below the opening protrusion, a moving rod extends out of the lower part of the opening handle, and a protrusion block with saw teeth is arranged on the moving rod; the saw teeth of the lug are meshed with the saw teeth of the protruding part of the gear structure; a lug moving groove for the lug to move is arranged on one side of the longitudinal deep groove; the rotary structure is arranged to ensure that the lug drives the gear structure to rotate so as to reach the forward pushing and withdrawing of the extension rod and ensure the forward pushing and backward positions.
Further, the gear structure and the extending rod are of an integrated structure; the part extending into the hole is provided with a gear moving groove with a larger diameter for the gear structure to move; the rotating structure is provided with corresponding thread sections on the stretching-in hole and the stretching-in rod. Above-mentioned setting is through pushing down vertical press lever, because the abrupt piece moves down, and the sawtooth on the abrupt piece drives gear structure and rotates, and then drives and stretch into the pole and rotate and get into the PCR tube hole, realizes dying to the lock of PCR pipe, reaches the mesh of antiskid play, further pushes down and then can drive to open the abrupt upward movement according to the press lever, opens PCR pipe, and whole process only needs to push down and can accomplish according to the press lever, and easy operation is convenient.
Or, the gear structure cover is established on stretching into the pole, and revolution mechanic does: the thread structures which are arranged on the inner side of the gear structure and correspond to the outer sides of the extension rods are arranged; the aforesaid sets up through pushing down vertical press lever, because the abrupt piece moves down, sawtooth on the abrupt piece drives gear structure and rotates, gear structure rotates and drives inside helicitic texture and rotates, and then reach the drive and stretch into the pole and rotate the purpose of stretching into, stretch into the pole and rotate and get into the PCR tube hole, the realization is died the lock of PCR pipe, reach the mesh that the antiskid is gone out, further push down press lever then can drive and open the abrupt upward movement, open the PCR pipe, whole process only needs to push down and can accomplish according to the press lever, easy operation is convenient.
Furthermore, a contact ring which is consistent with the shape of the wall of the PCR tube is arranged at the front end of the extensible column, and the anti-slip effect can be improved by the arrangement of the contact ring.
Further, 3-8 PCR tube bases and open tube parts which are connected with each other are arranged; among them, 4 to 6 are preferably provided; this arrangement can achieve the problem of setting up multiple PCR tubes at once.
Furthermore, a base plate which is wider than the base part of the PCR tube is arranged at the bottom of the base parts of the PCR tube which are connected with each other; the stability of structure can be fine increase in the setting of base plate.
Further, a uniform pressing structure of the pressing cap is arranged; the pressing cap pressing structure comprises an inlet into which a plurality of pressing caps can be inserted simultaneously; a rear hand grip is also included.
Further, a uniform opening structure of the opening handle is arranged; the opening structure of the opening handle comprises an insertion port into which a plurality of opening handles are inserted simultaneously; a rear hand grip is also included.
Above-mentioned press the cap to press down the structure or open the handle and open the setting of structure and can realize once opening the purpose of a plurality of pipes, when single pipe is opened to needs, through controlling the handle of opening that each pipe corresponds or press the cap to realize single purpose of opening, it is nimble more convenient to operate, accomplishes according to concrete work demand.
Further, for preventing opening rocking of in-process apparatus, set up the subsides of gluing in the apparatus bottom, through gluing the apparatus fixed with specific position, increase the stability in the use.
Furthermore, the PCR tube base and the tube opening part are made of hard metal materials or hard plastics, and the PCR tube base and the tube opening part are of solid structures, so that the stability in the use process can be improved due to the arrangement of the solid structures.
When in use, the PCR tube is put into the tube hole; prevent the pipe roll-off through pressing down the press cap, open opening of realization that the handle can be very simple and convenient to PCR pipe through lifting, whole process is convenient hard, can effectively prevent to pollute, is a rational in infrastructure, and easy operation has the PCR pipe of very good practical function and opens the apparatus.
Drawings
FIG. 1 is a schematic view of the overall structure of embodiment 5 of the present invention;
FIG. 2 is a schematic view of the overall structure of embodiment 3 of the present invention;
FIG. 3 is a schematic diagram of the overall structure of a PCR-free structure according to example 3 of the present invention;
FIG. 4 is a schematic view of the overall longitudinal cross-sectional structure of embodiment 3 of the present invention;
fig. 5 is a structural schematic diagram of an open state in embodiment 3 of the present invention;
FIG. 6 is a schematic structural view of an open pipe portion in examples 1 to 4 of the present invention;
FIG. 7 is a partial enlarged structural view of the pipe slipping-out preventing structure according to embodiments 3 and 4 of the present invention;
FIG. 8 is a schematic view of the overall structure of embodiments 5 and 6 of the present invention;
FIG. 9 is a schematic view of the overall longitudinal cross-sectional structure of embodiment 5 of the present invention;
FIG. 10 is a schematic diagram illustrating a longitudinal cross-sectional structure of an embodiment 5 of the present invention based on a longitudinal reference plane extending through a center of the hole;
FIG. 11 is a schematic structural view of an open tubular portion in example 5 of the present invention;
FIG. 12 is a partial enlarged view of the structure of the cam and gear of the present invention;
FIG. 13 is a schematic view of the entire structure of embodiment 7 of the present invention;
in the figure, 1, PCR tube base; 11. PCR tube holes; 12. a positioning protrusion; 21. an opening projection; 22. a connecting section; 23. an opening handle; 24. a cylindrical swivel; 25. a cylindrical rotating shaft; 3. the tube cap of the PCR tube protrudes; 41. a through hole; 42. can extend into the column; 43. pressing the cap; 44. a lateral spring; 5. a pressing structure of a pressing cap; 6. an opening handle opening structure; 71. an access hole; 72. extending into the rod; 73. a gear structure; 74. a bump; 75. a lug moving groove; 76. a threaded segment; 77. a gear moving groove; 78. longitudinal deep grooves; 79. a travel bar; 8. a substrate.
Detailed Description
Embodiment 1 molecular detection laboratory is with supplementary pipe apparatus of opening
An auxiliary tube opening instrument for a molecular detection laboratory comprises a PCR tube base 1 and a tube opening part; the PCR tube is characterized in that the tube opening part is arranged above the PCR tube base 1, the tube opening part can rotate along one side of the PCR tube, and the PCR tube hole 11 is arranged on the PCR tube base 1; the opening tube part comprises a rotating part connected with the PCR tube, an opening protrusion 21 corresponding to the projection 3 of the tube cap of the PCR tube, and a connecting section 22 which connects the rotating part with the opening protrusion 21 and does not influence the placing of the PCR tube; the rotating part and the opening projection 21 are arranged at two positions opposite to the PCR base; the opening lug 21 extends backwards to form an opening handle 23; the position of the opening projection 21 corresponds to the projection 3 of the PCR tube cap. In this way, by rotating the opening handle 23 upward, the PCR cap protrusion 3 is driven by the opening protrusion 21 to move upward to open the cap. The shape of the opening protrusion 21 is consistent with that of the PCR tube cap protrusion 3, which is convenient and better, and makes the opening smoother.
The rotating part comprises a cylindrical rotating ring 24 arranged on the PCR base and a cylindrical rotating shaft 25 inserted into the cylindrical rotating ring 24, the length of the cylindrical rotating shaft 25 is longer than that of the cylindrical rotating ring 24, and a connecting section 22 is arranged on the part of the cylindrical rotating shaft 25 extending out of the cylindrical rotating ring.
The connecting section 22 is arranged on the outer edge of the PCR tube hole 11, has a shape similar to the outer edge and is larger than the tube hole in size; the other side of the connecting section 22 converges at the opening projection 21. The arrangement can effectively place the PCR tube and prevent interference.
For preventing opening rocking of in-process apparatus, set up the subsides of gluing in the apparatus bottom, through gluing the apparatus fixed with specific position, increase the stability in the use. The PCR tube base 1 and the tube opening part are made of hard metal materials or hard plastics, the PCR tube base 1 and the tube opening part are of solid structures, and the stability in the using process can be improved due to the arrangement of the solid structures.
Embodiment 2 molecular detection laboratory is with supplementary apparatus of opening a tub
An auxiliary tube opening instrument for a molecular detection laboratory comprises a PCR tube base 1 and a tube opening part; the PCR tube is characterized in that the tube opening part is arranged above the PCR tube base 1, the tube opening part can rotate along one side of the PCR tube, and the PCR tube hole 11 is arranged on the PCR tube base 1; the opening tube part comprises a rotating part connected with the PCR tube, an opening protrusion 21 corresponding to the projection 3 of the tube cap of the PCR tube, and a connecting section 22 which connects the rotating part with the opening protrusion 21 and does not influence the placing of the PCR tube; the rotating part and the opening projection 21 are arranged at two positions opposite to the PCR base; the opening lug 21 extends backwards to form an opening handle 23; the position of the opening projection 21 corresponds to the projection 3 of the PCR tube cap. In this way, by rotating the opening handle 23 upward, the PCR cap protrusion 3 is driven by the opening protrusion 21 to move upward to open the cap.
The shape of the opening protrusion 21 is consistent with that of the PCR tube cap protrusion 3, which is convenient and better, and makes the opening smoother.
Two positioning protrusions 12 with the same shape as the opening protrusion 21 are arranged on the outer edges of two sides of the opening protrusion 21 on the PCR tube base 1, and the two positioning protrusions 12 form a placing notch for placing the PCR tube cap protrusion 3. The arrangement can ensure the accurate positioning and placement of the PCR tube during use and the deviation of the placement position.
The rotating part comprises a cylindrical rotating ring 24 arranged on the PCR base and a cylindrical rotating shaft 25 inserted into the cylindrical rotating ring 24, the length of the cylindrical rotating shaft 25 is longer than that of the cylindrical rotating ring 24, and a connecting section 22 is arranged on the part of the cylindrical rotating shaft 25 extending out of the cylindrical rotating ring.
The connecting section 22 is arranged on the outer edge of the PCR tube hole 11, has a shape similar to the outer edge and is larger than the tube hole in size; the other side of the connecting section 22 converges at the opening projection 21. The arrangement can effectively place the PCR tube and prevent interference.
For preventing opening rocking of in-process apparatus, set up the subsides of gluing in the apparatus bottom, through gluing the apparatus fixed with specific position, increase the stability in the use. The PCR tube base 1 and the tube opening part are made of hard metal materials or hard plastics, the PCR tube base 1 and the tube opening part are of solid structures, and the stability in the using process can be improved due to the arrangement of the solid structures.
Embodiment 3 molecular detection laboratory is with supplementary apparatus of opening a tub
An auxiliary tube opening instrument for a molecular detection laboratory comprises a PCR tube base 1 and a tube opening part; the PCR tube is characterized in that the tube opening part is arranged above the PCR tube base 1, the tube opening part can rotate along one side of the PCR tube, and the PCR tube hole 11 is arranged on the PCR tube base 1; the opening tube part comprises a rotating part connected with the PCR tube, an opening protrusion 21 corresponding to the projection 3 of the tube cap of the PCR tube, and a connecting section 22 which connects the rotating part with the opening protrusion 21 and does not influence the placing of the PCR tube; the rotating part and the opening projection 21 are arranged at two positions opposite to the PCR base; the opening lug 21 extends backwards to form an opening handle 23; the position of the opening projection 21 corresponds to the projection 3 of the PCR tube cap. In this way, by rotating the opening handle 23 upward, the PCR cap protrusion 3 is driven by the opening protrusion 21 to move upward to open the cap.
The shape of the opening protrusion 21 is consistent with that of the PCR tube cap protrusion 3, which is convenient and better, and makes the opening smoother.
Two positioning protrusions 12 with the same shape as the opening protrusion 21 are arranged on the outer edges of two sides of the opening protrusion 21 on the PCR tube base 1, and the two positioning protrusions 12 form a placing notch for placing the PCR tube cap protrusion 3. The arrangement can ensure the accurate positioning and placement of the PCR tube during use and the deviation of the placement position.
The rotating part comprises a cylindrical rotating ring 24 arranged on the PCR base and a cylindrical rotating shaft 25 inserted into the cylindrical rotating ring 24, the length of the cylindrical rotating shaft 25 is equal to that of the cylindrical rotating ring, 2 notches are arranged on the cylindrical rotating ring 24, and the connecting section 22 is connected with the cylindrical rotating shaft 25 through the notches.
The connecting section 22 is arranged on the outer edge of the PCR tube hole 11, has a shape similar to the outer edge and is larger than the tube hole in size; the other side of the connecting section 22 converges at the opening projection 21. The arrangement can effectively place the PCR tube and prevent interference.
A tube slipping-out preventing structure is further arranged on the side wall of the PCR tube base 1; the tube slipping-out preventing structure comprises a through hole 41 arranged on the side wall of the PCR tube base 1 and an extensible column 42 arranged in the through hole 41; a pressing cap 43 is provided to extend into the rear end of the post 42. The tube slipping-out preventing structure also comprises a transverse spring 44, one end of which is connected with the pressing cap 43 and the other end of which is connected with the side wall of the PCR tube base 1; the extendable post 42 extends into the transverse spring 44. The setting can effectively ensure the control of the PCR tube when the tube is opened, and prevent the separation of the PCR tube when the tube is opened and influence the tube opening effect.
For preventing opening rocking of in-process apparatus, set up the subsides of gluing in the apparatus bottom, through gluing the apparatus fixed with specific position, increase the stability in the use. The PCR tube base 1 and the tube opening part are made of hard metal materials or hard plastics, the PCR tube base 1 and the tube opening part are of solid structures, and the stability in the using process can be improved due to the arrangement of the solid structures.
Embodiment 4 molecular detection laboratory is with supplementary apparatus of opening a tub
An auxiliary tube opening instrument for a molecular detection laboratory comprises a PCR tube base 1 and a tube opening part; the PCR tube is characterized in that the tube opening part is arranged above the PCR tube base 1, the tube opening part can rotate along one side of the PCR tube, and the PCR tube hole 11 is arranged on the PCR tube base 1; the opening tube part comprises a rotating part connected with the PCR tube, an opening protrusion 21 corresponding to the projection 3 of the tube cap of the PCR tube, and a connecting section 22 which connects the rotating part with the opening protrusion 21 and does not influence the placing of the PCR tube; the rotating part and the opening projection 21 are arranged at two positions opposite to the PCR base; the opening lug 21 extends backwards to form an opening handle 23; the position of the opening projection 21 corresponds to the projection 3 of the PCR tube cap. In this way, by rotating the opening handle 23 upward, the PCR cap protrusion 3 is driven by the opening protrusion 21 to move upward to open the cap.
The shape of the opening protrusion 21 is consistent with that of the PCR tube cap protrusion 3, which is convenient and better, and makes the opening smoother.
Two positioning protrusions 12 with the same shape as the opening protrusion 21 are arranged on the outer edges of two sides of the opening protrusion 21 on the PCR tube base 1, and the two positioning protrusions 12 form a placing notch for placing the PCR tube cap protrusion 3. The arrangement can ensure the accurate positioning and placement of the PCR tube during use and the deviation of the placement position.
The rotating part comprises a cylindrical rotating ring 24 arranged on the PCR base and a cylindrical rotating shaft 25 inserted into the cylindrical rotating ring 24, the length of the cylindrical rotating shaft 25 is longer than that of the cylindrical rotating ring 24, and a connecting section 22 is arranged on the part of the cylindrical rotating shaft 25 extending out of the cylindrical rotating ring.
The connecting section 22 is arranged on the outer edge of the PCR tube hole 11, has a shape similar to the outer edge and is larger than the tube hole in size; the other side of the connecting section 22 converges at the opening projection 21. The arrangement can effectively place the PCR tube and prevent interference.
A tube slipping-out preventing structure is further arranged on the side wall of the PCR tube base 1; the tube slipping-out preventing structure comprises a through hole 41 arranged on the side wall of the PCR tube base 1 and an extensible column 42 arranged in the through hole 41; a pressing cap 43 is provided to extend into the rear end of the post 42. The tube slipping-out preventing structure also comprises a transverse spring 44, one end of which is connected with the pressing cap 43 and the other end of which is connected with the side wall of the PCR tube base 1; the extendable post 42 extends into the transverse spring 44. The setting can effectively ensure the control of the PCR tube when the tube is opened, and prevent the separation of the PCR tube when the tube is opened and influence the tube opening effect.
The front end of the extendable post 42 is provided with a contact ring with the shape consistent with that of the PCR tube wall, and the contact ring can increase the anti-slip effect.
For preventing opening rocking of in-process apparatus, set up the subsides of gluing in the apparatus bottom, through gluing the apparatus fixed with specific position, increase the stability in the use. The PCR tube base 1 and the tube opening part are made of hard metal materials or hard plastics, the PCR tube base 1 and the tube opening part are of solid structures, and the stability in the using process can be improved due to the arrangement of the solid structures.
Embodiment 5 molecular detection laboratory is with supplementary apparatus of opening a tub
An auxiliary tube opening instrument for a molecular detection laboratory comprises a PCR tube base 1 and a tube opening part; the PCR tube is characterized in that the tube opening part is arranged above the PCR tube base 1, the tube opening part can rotate along one side of the PCR tube, and the PCR tube hole 11 is arranged on the PCR tube base 1; the opening tube part comprises a rotating part connected with the PCR tube, an opening protrusion 21 corresponding to the projection 3 of the tube cap of the PCR tube, and a connecting section 22 which connects the rotating part with the opening protrusion 21 and does not influence the placing of the PCR tube; the rotating part and the opening projection 21 are arranged at two positions opposite to the PCR base; the opening lug 21 extends backwards to form an opening handle 23; the position of the opening projection 21 corresponds to the projection 3 of the PCR tube cap. In this way, by rotating the opening handle 23 upward, the PCR cap protrusion 3 is driven by the opening protrusion 21 to move upward to open the cap.
The shape of the opening protrusion 21 is consistent with that of the PCR tube cap protrusion 3, which is convenient and better, and makes the opening smoother.
Two positioning protrusions 12 with the same shape as the opening protrusion 21 are arranged on the outer edges of two sides of the opening protrusion 21 on the PCR tube base 1, and the two positioning protrusions 12 form a placing notch for placing the PCR tube cap protrusion 3. The arrangement can ensure the accurate positioning and placement of the PCR tube during use and the deviation of the placement position.
The rotating part comprises a cylindrical rotating ring 24 arranged on the PCR base and a cylindrical rotating shaft 25 inserted into the cylindrical rotating ring 24, the length of the cylindrical rotating shaft 25 is longer than that of the cylindrical rotating ring 24, and a connecting section 22 is arranged on the part of the cylindrical rotating shaft 25 extending out of the cylindrical rotating ring.
The connecting section 22 is arranged on the outer edge of the PCR tube hole 11, has a shape similar to the outer edge and is larger than the tube hole in size; the other side of the connecting section 22 converges at the opening projection 21. The arrangement can effectively place the PCR tube and prevent interference.
The tube slipping-off preventing structure comprises an extending hole 71 extending into the tube hole 11 of the PCR tube, and an extending rod 72 is arranged in the extending hole 71; a gear structure 73 with a larger diameter is arranged on the extending rod 72, and one side of the gear structure 73 protrudes from the extending hole 71; a longitudinal deep groove 78 is arranged on the part of the PCR tube base 1 below the opening protrusion 21, a moving rod 79 extends out of the lower part of the opening handle 23, and a protrusion 74 with saw teeth is arranged on the moving rod 79; the teeth of the lugs 74 engage with the teeth of the projecting portion of the gear structure 73; a lug moving groove 75 for moving the lug 74 is formed on one side of the longitudinal deep groove 78; the rotation structure is provided to ensure that the protrusion 74 rotates the gear structure 73 to reach the forward and backward pushing and withdrawing of the inserting rod 72 and to ensure the forward and backward pushing positions. The gear structure 73 and the extending rod 72 are of an integral structure; a gear moving groove 77 with a larger diameter for moving the gear structure 73 is formed at the portion of the insertion hole 71; the rotation structure is provided with corresponding thread sections 76 on the access hole 71 and the access rod 72. Above-mentioned setting is through pushing down vertical press lever, because the lug 74 moves down, and the sawtooth on the lug 74 drives gear structure 73 and rotates, and then drives and stretch into pole 72 and rotate and get into PCR tube hole 11, realizes dying to the lock of PCR pipe, reaches the mesh of antiskid play, and the press lever is then can drive to open the lug 21 and move up to the further pushing down, opens PCR pipe, and whole process only need push down the press lever and can accomplish easy operation convenience.
The front end of the extension rod 72 is provided with a contact ring which has the same shape with the PCR tube wall, and the arrangement of the contact ring can increase the anti-slip effect.
For preventing opening rocking of in-process apparatus, set up the subsides of gluing in the apparatus bottom, through gluing the apparatus fixed with specific position, increase the stability in the use. The PCR tube base 1 and the tube opening part are made of hard metal materials or hard plastics, the PCR tube base 1 and the tube opening part are of solid structures, and the stability in the using process can be improved due to the arrangement of the solid structures.
Embodiment 6 auxiliary tube opening instrument for molecular detection laboratory
An auxiliary tube opening instrument for a molecular detection laboratory comprises a PCR tube base 1 and a tube opening part; the PCR tube is characterized in that the tube opening part is arranged above the PCR tube base 1, the tube opening part can rotate along one side of the PCR tube, and the PCR tube hole 11 is arranged on the PCR tube base 1; the opening tube part comprises a rotating part connected with the PCR tube, an opening protrusion 21 corresponding to the projection 3 of the tube cap of the PCR tube, and a connecting section 22 which connects the rotating part with the opening protrusion 21 and does not influence the placing of the PCR tube; the rotating part and the opening projection 21 are arranged at two positions opposite to the PCR base; the opening lug 21 extends backwards to form an opening handle 23; the position of the opening projection 21 corresponds to the projection 3 of the PCR tube cap. In this way, by rotating the opening handle 23 upward, the PCR cap protrusion 3 is driven by the opening protrusion 21 to move upward to open the cap.
The shape of the opening protrusion 21 is consistent with that of the PCR tube cap protrusion 3, which is convenient and better, and makes the opening smoother.
Two positioning protrusions 12 with the same shape as the opening protrusion 21 are arranged on the outer edges of two sides of the opening protrusion 21 on the PCR tube base 1, and the two positioning protrusions 12 form a placing notch for placing the PCR tube cap protrusion 3. The arrangement can ensure the accurate positioning and placement of the PCR tube during use and the deviation of the placement position.
The rotating part comprises a cylindrical rotating ring 24 arranged on the PCR base and a cylindrical rotating shaft 25 inserted into the cylindrical rotating ring 24, the length of the cylindrical rotating shaft 25 is longer than that of the cylindrical rotating ring 24, and a connecting section 22 is arranged on the part of the cylindrical rotating shaft 25 extending out of the cylindrical rotating ring.
The connecting section 22 is arranged on the outer edge of the PCR tube hole 11, has a shape similar to the outer edge and is larger than the tube hole in size; the other side of the connecting section 22 converges at the opening projection 21. The arrangement can effectively place the PCR tube and prevent interference.
A tube slipping-out preventing structure is further arranged on the side wall of the PCR tube base 1; the tube slipping-off preventing structure comprises an extending hole 71 extending into the tube hole 11 of the PCR tube, and an extending rod 72 is arranged in the extending hole 71; a gear structure 73 with a larger diameter is arranged on the extending rod 72, and one side of the gear structure 73 protrudes from the extending hole 71; a longitudinal deep groove 78 is arranged on the part of the PCR tube base 1 below the opening protrusion 21, a moving rod 79 extends out of the lower part of the opening handle 23, and a protrusion 74 with saw teeth is arranged on the moving rod 79; the teeth of the lugs 74 engage with the teeth of the projecting portion of the gear structure 73; a lug moving groove 75 for moving the lug 74 is formed on one side of the longitudinal deep groove 78; the rotation structure is provided to ensure that the protrusion 74 rotates the gear structure 73 to reach the forward and backward pushing and withdrawing of the inserting rod 72 and to ensure the forward and backward pushing positions. Gear structure 73 cover is established on stretching into pole 72, and the revolution mechanic does: the thread structure is arranged on the inner side of the gear structure 73 and corresponds to the outer side of the extending rod 72; the aforesaid sets up through pushing down vertical press rod, because the abrupt piece 74 moves down, sawtooth on the abrupt piece 74 drives gear structure 73 and rotates, gear structure 73 rotates and drives inside helicitic texture and rotates, and then reach the drive and stretch into the purpose that pole 72 rotated and stretched into, stretch into pole 72 and rotate and get into PCR tube hole 11, the realization dies the lock of PCR pipe, reach the mesh of antiskid, further push down and press the pole and then can drive and open abrupt 21 and move up, open PCR pipe, whole process only need push down and press the pole and can accomplish, easy operation is convenient.
The front end of the extension rod 72 is provided with a contact ring which has the same shape with the PCR tube wall, and the arrangement of the contact ring can increase the anti-slip effect.
For preventing opening rocking of in-process apparatus, set up the subsides of gluing in the apparatus bottom, through gluing the apparatus fixed with specific position, increase the stability in the use. The PCR tube base 1 and the tube opening part are made of hard metal materials or hard plastics, the PCR tube base 1 and the tube opening part are of solid structures, and the stability in the using process can be improved due to the arrangement of the solid structures.
Embodiment 7 molecular detection laboratory is with supplementary pipe apparatus of opening
An auxiliary tube opening instrument for a molecular detection laboratory comprises a PCR tube base 1 and a tube opening part; the PCR tube is characterized in that the tube opening part is arranged above the PCR tube base 1, the tube opening part can rotate along one side of the PCR tube, and the PCR tube hole 11 is arranged on the PCR tube base 1; the opening tube part comprises a rotating part connected with the PCR tube, an opening protrusion 21 corresponding to the projection 3 of the tube cap of the PCR tube, and a connecting section 22 which connects the rotating part with the opening protrusion 21 and does not influence the placing of the PCR tube; the rotating part and the opening projection 21 are arranged at two positions opposite to the PCR base; the opening lug 21 extends backwards to form an opening handle 23; the position of the opening projection 21 corresponds to the projection 3 of the PCR tube cap. In this way, by rotating the opening handle 23 upward, the PCR cap protrusion 3 is driven by the opening protrusion 21 to move upward to open the cap.
The shape of the opening protrusion 21 is consistent with that of the PCR tube cap protrusion 3, which is convenient and better, and makes the opening smoother.
Two positioning protrusions 12 with the same shape as the opening protrusion 21 are arranged on the outer edges of two sides of the opening protrusion 21 on the PCR tube base 1, and the two positioning protrusions 12 form a placing notch for placing the PCR tube cap protrusion 3. The arrangement can ensure the accurate positioning and placement of the PCR tube during use and the deviation of the placement position.
The rotating part comprises a cylindrical rotating ring 24 arranged on the PCR base and a cylindrical rotating shaft 25 inserted into the cylindrical rotating ring 24, the length of the cylindrical rotating shaft 25 is longer than that of the cylindrical rotating ring 24, and a connecting section 22 is arranged on the part of the cylindrical rotating shaft 25 extending out of the cylindrical rotating ring.
The connecting section 22 is arranged on the outer edge of the PCR tube hole 11, has a shape similar to the outer edge and is larger than the tube hole in size; the other side of the connecting section 22 converges at the opening projection 21. The arrangement can effectively place the PCR tube and prevent interference.
A tube slipping-out preventing structure is further arranged on the side wall of the PCR tube base 1; the tube slipping-out preventing structure comprises a through hole 41 arranged on the side wall of the PCR tube base 1 and an extensible column 42 arranged in the through hole 41; a pressing cap 43 is provided to extend into the rear end of the post 42. The tube slipping-out preventing structure also comprises a transverse spring 44, one end of which is connected with the pressing cap 43 and the other end of which is connected with the side wall of the PCR tube base 1; the extendable post 42 extends into the transverse spring 44. The setting can effectively ensure the control of the PCR tube when the tube is opened, and prevent the separation of the PCR tube when the tube is opened and influence the tube opening effect.
The front end of the extendable post 42 is provided with a contact ring with the shape consistent with that of the PCR tube wall, and the contact ring can increase the anti-slip effect.
Setting 5 PCR tube base 1 and open tube part connected with each other; this arrangement can achieve the problem of setting up multiple PCR tubes at once.
A base plate 8 which is wider than the width of the PCR tube base 1 is arranged at the bottom of the PCR tube base 1 which is connected with each other; the arrangement of the substrate 8 can well increase the stability of the structure.
Arranging a uniform pressing cap pressing structure 5; the pressing cap pressing structure 5 includes an insertion port into which a plurality of pressing caps 43 can be inserted simultaneously; a rear hand grip is also included. Arranging a uniform opening handle opening structure 6; the opening-handle opening structure 6 includes an insertion port into which a plurality of opening handles 23 are inserted simultaneously; a rear hand grip is also included. Above-mentioned press cap to press structure 5 or open the handle and open the purpose that structure 6 set up can realize once opening a plurality of pipes, when single pipe was opened to needs, through the handle 23 or the press cap 43 realization single purpose of opening that each pipe of control corresponds, it is more nimble convenient to operate, accomplishes according to concrete work demand.
For preventing opening rocking of in-process apparatus, set up the subsides of gluing in the apparatus bottom, through gluing the apparatus fixed with specific position, increase the stability in the use. The PCR tube base 1 and the tube opening part are made of hard metal materials or hard plastics, the PCR tube base 1 and the tube opening part are of solid structures, and the stability in the using process can be improved due to the arrangement of the solid structures.
The above description of the embodiments is only for the understanding of the present invention. It should be noted that modifications could be made to the invention without departing from the principle of the invention, which would also fall within the scope of the claims of the invention.

Claims (7)

1. An auxiliary tube opening instrument for a molecular detection laboratory comprises a PCR tube base (1) and a tube opening part; the device is characterized in that the tube opening part is arranged above the PCR tube base (1), the tube opening part can rotate along one side of the PCR tube, and the PCR tube hole (11) is arranged on the PCR tube base (1); the opening tube part comprises a rotating part connected with the PCR tube, an opening protrusion (21) corresponding to the tube cap protrusion (3) of the PCR tube, and a connecting section (22) which connects the rotating part with the opening protrusion (21) and does not influence the placing of the PCR tube; the rotating part and the opening projection (21) are arranged at two positions opposite to the PCR base; the opening projection (21) extends backwards to form an opening handle (23); the position of the opening protrusion (21) corresponds to the protrusion (3) of the PCR tube cap; the side wall of the PCR tube base (1) is also provided with a tube slipping-out preventing structure, so that the tube can be prevented from slipping out in the tube opening process; two positioning protrusions (12) with the same shape as the opening protrusion (21) are arranged on the outer edges of two sides of the opening protrusion (21) on the PCR tube base (1), and the two positioning protrusions (12) form a placing gap for placing the PCR tube cap protrusion (3); the rotating part comprises a cylindrical rotating ring (24) arranged on the PCR base and a cylindrical rotating shaft (25) inserted into the cylindrical rotating ring (24), the length of the cylindrical rotating shaft (25) is longer than that of the cylindrical rotating ring (24), and a connecting section (22) is arranged on the part, extending out of the cylindrical rotating ring, of the cylindrical rotating shaft (25); or the length of the cylindrical rotating shaft (25) is equal to that of the cylindrical rotating ring, 2 notches are arranged on the cylindrical rotating ring (24), and the connecting section (22) is connected with the cylindrical rotating shaft (25) through the notches.
2. The molecular testing laboratory assisted tube opener according to claim 1, characterized in that the shape of the opening projection (21) is identical to the shape of the PCR tube cap projection (3).
3. The auxiliary tube opening device for the molecular testing laboratory according to claim 1, wherein the connecting section (22) is arranged at the outer edge of the PCR tube hole (11), is similar to the outer edge in shape, and is formed to be larger than the tube hole in size; the other side of the connecting section (22) is gathered at the opening projection (21).
4. The auxiliary tube opening instrument for the molecular testing laboratory according to claim 1, wherein the tube slipping-out preventing structure comprises a through hole (41) arranged on the side wall of the PCR tube part, and an extensible column (42) arranged in the through hole (41); a pressing cap (43) is arranged at the rear end of the column (42).
5. The auxiliary tube opening instrument for the molecular testing laboratory according to claim 4, wherein the tube slipping preventing structure further comprises a transverse spring (44) with one end connected with the pressing cap (43) and one end connected with the side wall of the PCR tube; the extendable post (42) extends into the transverse spring (44).
6. The auxiliary tube opening device for the molecular testing laboratory according to claim 1, wherein the tube slipping preventing structure comprises an extending hole (71) extending into the hole (11) of the PCR tube, and an extending rod (72) is arranged in the extending hole (71); a gear structure (73) with a larger diameter is arranged on the extending rod (72), and one side of the gear structure (73) protrudes from the extending hole (71); a longitudinal deep groove (78) is arranged on the part of the PCR tube base (1) below the opening protrusion (21), a moving rod (79) extends out of the lower part of the opening protrusion (21), and a protrusion block (74) with saw teeth is arranged on the moving rod (79); the saw teeth of the lug (74) are meshed with the saw teeth of the protruding part of the gear structure (73); a lug moving groove (75) for moving the lug (74) is arranged at one side of the longitudinal deep groove (78); a rotation structure is provided to ensure that the protrusion (74) drives the gear structure (73) to rotate so as to reach the forward pushing and withdrawing of the extension rod (72) and ensure the forward pushing and backward positions.
7. The molecular testing laboratory auxiliary tube opener according to claim 6, characterized in that the gear structure (73) is an integral structure with the extending rod (72); a gear moving groove (77) with a larger diameter for moving the gear structure (73) is arranged at the part of the inserting hole (71); the rotating structure is provided with corresponding thread sections (76) arranged on the extending hole (71) and the extending rod (72); or the gear structure (73) is sleeved on the extending rod (72), and the rotating structure is as follows: the corresponding thread structure is arranged on the inner side of the gear structure (73) and the outer side of the extending rod (72).
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