CN108403923A - A kind of preparation method of Xuanmai Ganju grains medicinal extract - Google Patents
A kind of preparation method of Xuanmai Ganju grains medicinal extract Download PDFInfo
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- 239000000284 extract Substances 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 238000000605 extraction Methods 0.000 claims abstract description 28
- 238000009835 boiling Methods 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 238000010792 warming Methods 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 13
- 241000208671 Campanulaceae Species 0.000 claims abstract description 10
- 239000006071 cream Substances 0.000 claims abstract description 7
- 239000012141 concentrate Substances 0.000 claims abstract description 6
- 238000005119 centrifugation Methods 0.000 claims abstract description 5
- 238000001914 filtration Methods 0.000 claims abstract description 5
- 238000012545 processing Methods 0.000 claims abstract description 4
- 239000000706 filtrate Substances 0.000 claims abstract description 3
- 238000005470 impregnation Methods 0.000 claims description 6
- 235000013339 cereals Nutrition 0.000 claims 4
- 241000675108 Citrus tangerina Species 0.000 claims 1
- 241000209140 Triticum Species 0.000 claims 1
- 235000021307 Triticum Nutrition 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 23
- KVRQGMOSZKPBNS-FMHLWDFHSA-N Harpagoside Chemical compound O([C@@H]1OC=C[C@@]2(O)[C@H](O)C[C@]([C@@H]12)(C)OC(=O)\C=C\C=1C=CC=CC=1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O KVRQGMOSZKPBNS-FMHLWDFHSA-N 0.000 abstract description 19
- KVRQGMOSZKPBNS-BYYMOQGZSA-N Harpagoside Natural products C[C@@]1(C[C@@H](O)[C@@]2(O)C=CO[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H]12)OC(=O)C=Cc4ccccc4 KVRQGMOSZKPBNS-BYYMOQGZSA-N 0.000 abstract description 19
- 238000002791 soaking Methods 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 2
- 238000004904 shortening Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 description 19
- 239000007788 liquid Substances 0.000 description 10
- 239000003651 drinking water Substances 0.000 description 9
- 235000020188 drinking water Nutrition 0.000 description 9
- 238000003860 storage Methods 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 5
- 230000008595 infiltration Effects 0.000 description 5
- 238000001764 infiltration Methods 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 229930182489 iridoid glycoside Natural products 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- ZUKLFFYDSALIQW-MSUKCBDUSA-N Iridoid glycoside Chemical compound [H][C@]12CC[C@H](C(O)=O)[C@@]1([H])[C@H](OC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)OC=C2 ZUKLFFYDSALIQW-MSUKCBDUSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
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- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 2
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- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- VZRKWGPIZJDNHC-LUNVCWBOSA-N Polygalic acid Polymers CC1(C)CC[C@@]2(CCC3=C(CC[C@@H]4[C@@]5(C)C[C@H](O)[C@H](O)[C@](C)([C@@H]5CC[C@@]34C)C(O)=O)[C@@H]2C1)C(O)=O VZRKWGPIZJDNHC-LUNVCWBOSA-N 0.000 description 1
- VZRKWGPIZJDNHC-UHFFFAOYSA-N Polygalic acid Natural products CC1(C)CCC2(CCC3=C(CCC4C5(C)CC(O)C(O)C(C)(C5CCC34C)C(O)=O)C2C1)C(O)=O VZRKWGPIZJDNHC-UHFFFAOYSA-N 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- WQLVFSAGQJTQCK-UHFFFAOYSA-N diosgenin Natural products CC1C(C2(CCC3C4(C)CCC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 WQLVFSAGQJTQCK-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical group O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- -1 iridoid glycosides compound Chemical class 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- NWMIYTWHUDFRPL-UHFFFAOYSA-N sapogenin Natural products COC(=O)C1(CO)C(O)CCC2(C)C1CCC3(C)C2CC=C4C5C(C)(O)C(C)CCC5(CCC34C)C(=O)O NWMIYTWHUDFRPL-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The present invention relates to a kind of preparation methods of Xuanmai Ganju grains medicinal extract, it is characterised in that its processing step is：Radix scrophulariae is infiltrated into 2~3h first, then mixes it with Radix Ophiopogonis, Radix Glycyrrhizae, campanulaceae, 9~10 times of amount water is added to impregnate 25~30min; it is warming up to boiling later and carries out first time extraction, filters, 9~10 times of amount water are added in gained filter residue; it is warming up to boiling and carries out second of extraction; 7~8 times of amount water are added in gained filter residue, is warming up to boiling and carries out third time extraction for secondary filter; merge filtrate after filtering three times; concentration stands, centrifugation, then concentrates, receives cream.The present invention is handled Chinese medicine Xuanmai Ganju grains raw material using the method for shortening soaking time, to improve the content of harpagoside in Xuanmai Ganju grains medicinal extract, meanwhile, technique takes corresponding shorten.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, more particularly to a kind of preparation method of Xuanmai Ganju grains medicinal extract.
Background technology
Xuanmai Ganju grains are matched by radix scrophulariae, Radix Glycyrrhizae, Radix Ophiopogonis and four taste Chinese medicinal herbs of campanulaceae, function with cure mainly：
Heat-clearing enriching yin, dispelling phlegm and relieving sore-throat.For fire excess from yin deficiency, asthenic fire floating upward, mouth and nose drying, abscess of throat.It is the Chinese medicine Cheng Fang of classics, is
《Chinese Pharmacopoeia》Version in 2015 includes kind, it is specified that radix scrophulariae content is with harpagoside in Xuanmai Ganju grains finished product（C24H30O11）
Meter, every bag must not be less than 25mg.
The content of harpagoside directly affects finished product content in Xuanmai Ganju grains medicinal extract, and harpagoside content comes from medicinal material
Radix scrophulariae, and the quality of radix scrophulariae has prodigious influence for the effect of drug, so radix scrophulariae medicinal material in Xuanmai Ganju grains medicinal extract
Pre-treatment, processing, extraction concentration link it is most important.
In the prior art, it is typically using infiltration, for a long time immersion for Xuanmai Ganju grains（3h or more）, decoct extraction
Method prepared, this method has the following problems：It 1, cannot be abundant by the active ingredient harpagoside in radix scrophulariae medicinal material
It extracts, causes harpagoside content in Xuanmai Ganju grains medicinal extract relatively low, by calculating, every batch of Xuanmai Ganju grains medicinal extract
Middle harpagoside content is far below harpagoside theoretical content in input radix scrophulariae medicinal material；2, soaking time is long, at least wants 3 small
When, cause technique to take longer.
Invention content
The purpose of the present invention is that the defect for overcoming the above-mentioned prior art, provides one kind and effectively improving Xuanmai Ganju grains
Harpagoside content in medicinal extract, and then Xuanmai Ganju grains final product quality is improved, and technique takes short Xuanmai Ganju grains leaching
The preparation method of cream.
The technical solution taken for achieving the above object is：
A kind of preparation method of Xuanmai Ganju grains medicinal extract, it is characterised in that its processing step is：First by radix scrophulariae infiltrate 2~
Then 3h mixes it with Radix Ophiopogonis, Radix Glycyrrhizae, campanulaceae, add 9~10 times of amount water to impregnate 25~30min, be warming up to boiling later and carry out
It extracts, filters for the first time, 9~10 times of amount water are added in gained filter residue, be warming up to boiling and extract for the second time, secondary filter,
7~8 times of amount water are added in gained filter residue, is warming up to boiling and carries out third time extraction, merge filtrate after filtering three times, concentration is quiet
It sets, centrifuge, then concentrate, receive cream.
1.5~2h of extraction time first time, second of 0.5~1h of extraction time, third time extraction time 0.5~
1h。
Made Xuanmai Ganju grains medicinal extract proportion 1.32~1.35 at 65 DEG C.
Suitable quantity of water is poured in the impregnation process, 2-3 times, is poured per hour 1 time.
Harpagoside belongs to iridoid glycosides compound, and molecular weight is typically small, has polar functional group mostly, partially close
Aqueous, soluble easily in water, methanol dissolves in ethyl alcohol, acetone and n-butanol, and it is organic molten to be insoluble in the lipophilicitys such as chloroform, ether, benzene
Agent.The hydrophily of iridoid glycoside is stronger compared with the hydrophily of its aglycon.Iridoid glycoside is very sensitive to acid, and glycosidic bond is easily sour
Hydrolysis, the aglycon of generation is very unstable, and polymerisation easily occurs, under different hydrolysising conditions（Temperature, acidity etc.）, generate different
The variation of color or precipitation.
In general, the immersion of Xuanmai Ganju grains before extraction is all by 4 kinds of medicinal materials：Radix scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae, campanulaceae are simultaneously
It is put into extraction tank and impregnates 3h or more, since the chemical composition of Chinese medicine is extremely complex, Radix Glycyrrhizae main component is glycyrrhizic acid, radix scrophulariae
In contain cinnamic acid, the campanulaceae hydrolysis of containing platycodoside generates the mixture that sapogenin is triterpenic acid, and one of which is polygalic acid,
These three acid can promote the hydrolysis and variation of harpagoside, be dropped so as to cause harpagoside content in Xuanmai Ganju grains medicinal extract
Low, the rate of transform of the harpagoside from medicinal material to medicinal extract reduces, and eventually leads to that finished product content is low, and pharmaceutical effectiveness is bad, quality risk
Greatly.
Based on the above reasons, the present invention using shorten soaking time method come to Chinese medicine Xuanmai Ganju grains raw material
It is handled, influence of other medicinal material middle acid substances to harpagoside is avoided, to improve Xuanmai Ganju grains medicinal extract
The content of middle harpagoside, experiment show：Harpagoside content is promoted to 0.119% by 0.042% in Xuanmai Ganju grains medicinal extract,
By calculating, the harpagoside rate of transform is promoted to 7.1% by 2.1% in medicinal material.
Specific implementation method
The present invention is explained with example, it should be understood that example is for illustrating rather than to the present invention below
Limitation.The scope of the present invention is determined with core content according to claims.
Xuanmai Ganju grains prescription：Radix scrophulariae 80g, Radix Glycyrrhizae 80g, Radix Ophiopogonis 80g, campanulaceae 80g.
Embodiment 1
（1）Infiltration：Clean radix scrophulariae (medicine materical crude slice) is placed in bubble profit slot, 2~3h is infiltrated, suitable quantity of water, 2-3 is poured in impregnation process
It is secondary, it pours per hour 1 time, accomplishes that medicine is permeable most.
（2）Radix scrophulariae (medicine materical crude slice), Radix Ophiopogonis (medicine materical crude slice), Radix Glycyrrhizae (extraction medicine materical crude slice), campanulaceae (medicine materical crude slice) input are carried in prescription ratio
It takes in tank, the drinking water of 9~10 times of medicinal material input amounts is added, impregnate 25~30min, then heat to boiling and carry out for the first time
Extraction, temperature control keep 1.5~2h of boiling at 94~100 DEG C, stop heating, and 80 mesh screens, feed liquid warp are installed on filter
It is squeezed into storage tank after filter filtering, the drinking water of 9~10 times of medicinal material input amounts is added in filter residue, is warming up to boiling and carries out second
Extraction, temperature control keep boiling 0.5-1h, feed liquid to squeeze into after being filtered in storage tank and carried with first time at 94~100 DEG C
Liquid is taken to merge, the drinking water of 7~8 times of medicinal material input amounts is added in filter residue, is warming up to boiling and carries out third time extraction, temperature control exists
94~100 DEG C keep boiling 0.5-1h, and feed liquid is squeezed into after being filtered in storage tank to be merged with preceding extracting solution twice, is concentrated,
It stands, centrifugation, then concentrates, receives cream, final proportion reaches 1.32~1.35（65℃）.
Comparative example 1
（1）Infiltration：Clean radix scrophulariae (medicine materical crude slice) is placed in bubble profit slot, 3h is infiltrated, 4 water is poured in right amount in impregnation process, per small
When pour 1 time, accomplish that medicine is permeable most.
（2）Radix scrophulariae (medicine materical crude slice), Radix Ophiopogonis (medicine materical crude slice), Radix Glycyrrhizae (extraction medicine materical crude slice), campanulaceae (medicine materical crude slice) input are carried in prescription ratio
It takes in tank, the drinking water of about 10 times of medicinal material input amounts is added, impregnate 3h, then heat to boiling and carry out first time extraction, temperature
Control keeps boiling 1.5h at 94~100 DEG C, stops heating, 80 mesh screens is installed on filter, after feed liquid is filtered
It squeezes into storage tank, the drinking water of about 10 times of medicinal material input amounts is added in filter residue, is warming up to boiling and carries out second of extraction, temperature control
Boiling 1h is kept at 94~100 DEG C, feed liquid is squeezed into after being filtered in storage tank to be merged with first time extracting solution, and filter residue is added
The drinking water of about 8 times of medicinal material input amounts is warming up to boiling and carries out third time extraction, and temperature control keeps boiling at 94~100 DEG C
1h, feed liquid is squeezed into after being filtered in storage tank to be merged with preceding extracting solution twice, is concentrated, and is stood, centrifugation, then concentrate, receive cream,
Final proportion reaches 1.32~1.35（65℃）.
Comparative example 2
（1）It does not infiltrate：Clean radix scrophulariae (medicine materical crude slice) is directly fed intake, without infiltration.
（2）Radix scrophulariae (medicine materical crude slice), Radix Ophiopogonis (medicine materical crude slice), Radix Glycyrrhizae (extraction medicine materical crude slice), campanulaceae (medicine materical crude slice) input are carried in prescription ratio
It takes in tank, the drinking water of about 10 times of medicinal material input amounts is added, impregnate 0.5h, then heat to boiling and carry out first time extraction, temperature
Degree control keeps boiling 1.5h at 94~100 DEG C, stops heating, installs 80 mesh screens on filter, feed liquid is filtered
After squeeze into storage tank, the drinking water of about 10 times of medicinal material input amounts is added in filter residue, is warming up to boiling and carries out second and extracts, temperature control
System keeps boiling 1h at 94~100 DEG C, and feed liquid is squeezed into after being filtered in storage tank to be merged with first time extracting solution, and filter residue adds
The drinking water for entering about 8 times of medicinal material input amounts is warming up to boiling and carries out third time extraction, and temperature control keeps boiling at 94~100 DEG C
1h is risen, feed liquid is squeezed into after being filtered in storage tank to be merged with preceding extracting solution twice, is concentrated, and is stood, centrifugation, then concentrate, receive
Cream, final proportion reach 1.32~1.35（65℃）.
The experimental result of above-described embodiment and comparative example：
| Test method | Comparative example 1 | Embodiment 1 | Comparative example 2 |
| Infiltration | 3h is infiltrated, 4 water is poured in right amount in impregnation process, pours per hour 1 time. | 3h is infiltrated, 2-3 water is poured in right amount in impregnation process, pours per hour 1 time. | It directly feeds intake after medicinal material cleaning, moistens without bubble. |
| Soaking time before extraction | 3h | 20-30min | 0.5h |
| Harpagoside content in Xuanmai Ganju grains medicinal extract | 0.042% | 0.119% | 0.101% |
| The harpagoside rate of transform in medicinal material | 2.1% | 7.1% | 6.3% |
Claims (4)
1. a kind of preparation method of Xuanmai Ganju grains medicinal extract, it is characterised in that its processing step is：First by radix scrophulariae infiltrate 2~
Then 3h mixes it with Radix Ophiopogonis, Radix Glycyrrhizae, campanulaceae, add 9~10 times of amount water to impregnate 25~30min, be warming up to boiling later and carry out
It extracts for the first time, filtering, 9~10 times of amount water of addition in gained filter residue are warming up to boiling and carry out second of extraction, secondary filter institute
7~8 times of amount water are added in filter residue, be warming up to boiling and carry out third time extraction, merge filtrate after filtering three times, concentration, stand,
Centrifugation, then concentrate, receive cream.
2. the preparation method of Xuanmai Ganju grains medicinal extract described in accordance with the claim 1, it is characterised in that the first time extraction
1.5~2h of time, second of 0.5~1h of extraction time, third time 0.5~1h of extraction time.
3. the preparation method of Xuanmai Ganju grains medicinal extract described in accordance with the claim 1, which is characterized in that made profound wheat is sweet
Tangerine particle medicinal extract proportion 1.32~1.35 at 65 DEG C.
4. the preparation method of Xuanmai Ganju grains medicinal extract described in accordance with the claim 1, it is characterised in that in the impregnation process
Suitable quantity of water is poured, 2-3 times, is poured per hour 1 time.
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| CN114848749A (en) * | 2022-06-09 | 2022-08-05 | 四川旭阳药业有限责任公司 | Preparation method of Xuanmai Ganju granules |
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Address after: 750101 Telescope Development Zone, Yongning County, Yinchuan City, Ningxia Hui Autonomous Region Applicant after: Ningxia Zhouyang Pharmaceutical Co.,Ltd. Address before: 750101 Telescope Development Zone, Yongning County, Yinchuan City, Ningxia Hui Autonomous Region Applicant before: NINGXIA DUOWEI PHARMACEUTICAL Co.,Ltd. |
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