CN108403104A - Microcirculation is imaged Electrophysiology detection device - Google Patents
Microcirculation is imaged Electrophysiology detection device Download PDFInfo
- Publication number
- CN108403104A CN108403104A CN201810247145.XA CN201810247145A CN108403104A CN 108403104 A CN108403104 A CN 108403104A CN 201810247145 A CN201810247145 A CN 201810247145A CN 108403104 A CN108403104 A CN 108403104A
- Authority
- CN
- China
- Prior art keywords
- amplifier
- resistance
- output end
- circuit
- microcirculation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000001514 detection method Methods 0.000 title claims abstract description 77
- 230000004089 microcirculation Effects 0.000 title claims abstract description 63
- 238000002001 electrophysiology Methods 0.000 title claims abstract description 24
- 230000007831 electrophysiology Effects 0.000 title claims abstract description 24
- 210000000578 peripheral nerve Anatomy 0.000 claims abstract description 34
- 239000008280 blood Substances 0.000 claims abstract description 28
- 210000004369 blood Anatomy 0.000 claims abstract description 28
- 238000003384 imaging method Methods 0.000 claims abstract description 18
- 230000004936 stimulating effect Effects 0.000 claims abstract description 14
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 26
- 230000003321 amplification Effects 0.000 claims description 25
- 238000002955 isolation Methods 0.000 claims description 19
- 238000004088 simulation Methods 0.000 claims description 13
- 230000005611 electricity Effects 0.000 claims description 10
- 230000005540 biological transmission Effects 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 230000009467 reduction Effects 0.000 claims description 5
- 230000000638 stimulation Effects 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 3
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 16
- 238000010241 blood sampling Methods 0.000 abstract description 5
- 238000003745 diagnosis Methods 0.000 abstract description 3
- 208000015181 infectious disease Diseases 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 241001269238 Data Species 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0064—Body surface scanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7225—Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/725—Details of waveform analysis using specific filters therefor, e.g. Kalman or adaptive filters
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Signal Processing (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Artificial Intelligence (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Physiology (AREA)
- Psychiatry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Power Engineering (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
The microcirculation imaging Electrophysiology detection device of the present invention is related to a kind of medical diagnosis device, more particularly to the device for the bioelectrical signals for measuring human body or partes corporis humani point, frequently blood sampling leads to the burden of patient's physiology and psychology to needs and wound is not easy to heal when purpose is to overcome the problems, such as diagnosis or treat diabetic symptom, including peripheral nerve detection device, which includes stimulating electrode, stimulus signal processing circuit, detecting electrode, skin electrical signal detection circuit and peripheral nerve detection microprocessor；The beneficial effects of the invention are as follows：The application is easy to operate, need not take a blood sample when carrying out diabetes detection, avoids blood sampling wound and is not easy to heal and then cause the possibility of infection, and instrument is repeated and utilized.
Description
Technical field
The present invention relates to a kind of microcirculations to be imaged Electrophysiology detection device, and in particular to measures human body or partes corporis humani
The device of the bioelectrical signals divided.
Background technology
In diabetes early stage since people pay little attention to, the discovery opportunity delay of illness is can frequently result in, treatment is delayed.And
Diabetes belong to common one of the complication of diabetes, therefore can be by carrying out early screening to diabetes so as to can be
Illness finds early stage foot lesion before arriving, to find diabetes.During the diagnosing and treating of diabetes, generally adopt
With the method for blood sampling detection, repeatedly frequently take a blood sample for the patient with diabetes time-consuming and laborious, and due to diabetes
The characteristics of, the wound after blood sampling is also not easy to heal.
Invention content
It needs frequently to take a blood sample when the purpose of the invention is to overcome diagnosis or treatment diabetic symptom, and check fee of taking a blood sample
When laborious problem, provide a kind of microcirculation imaging Electrophysiology detection device and microcirculation detection method.
The microcirculation of the present invention is imaged Electrophysiology detection device, including peripheral nerve detection device and microcirculation imaging
Device, peripheral nerve detection device include stimulating electrode, stimulus signal processing circuit, detecting electrode, skin electrical signal detection circuit
Microprocessor is detected with peripheral nerve；
Stimulus signal processing circuit includes stimulus signal isolating amplifier circuit and current-to-voltage converting circuit, stimulus signal every
Voltage signal output end, the stimulation letter of voltage signal inputs electrical connection peripheral nerve detection microprocessor from amplifying circuit
Voltage signal inputs, the electricity of the voltage amplification signal output end electrical connection current-to-voltage converting circuit of number isolating amplifier circuit
The current output terminal of galvanic electricity voltage conversion circuit is electrically connected stimulating electrode；
Skin electrical signal detection circuit includes pre-amplification circuit, filter circuit, detection signal isolation amplifying circuit and processing
Device interface circuit, the current signal input electrical connection detecting electrode of pre-amplification circuit, the amplification electricity of pre-amplification circuit
Flow the current signal input of signal output end electrical connection filter circuit, the current signal output end electrical connection of filter circuit
It detects signal isolation amplifying circuit current input terminal, detect at the amplification current output terminal electrical connection of signal isolation amplifying circuit
The voltage signal output end electrical connection peripheral nerve detection of the current input terminal, processor interface circuit of managing device interface circuit is micro-
The voltage signal inputs of processor.Peripheral nerve detects microprocessor and is passed by general-purpose serial bus USB and terminal
Transmission of data.
Microcirculation imaging device includes near-infrared video camera, LED near-infrared light sources and microcirculation imaging microprocessor；
The LED near-infrared light sources that LED near-infrared light sources are used to emit two kinds of different wave lengths irradiate human foot respectively；
Near-infrared camera acquisition LED near-infrared light sources irradiate reflected light image caused by human foot；
The LED control letters of the LED control signal input terminal electrical connection microcirculation imaging microprocessor of LED near-infrared light sources
Number output end, the image input of the output end of image connection microcirculation imaging microprocessor of near-infrared video camera；Microcirculation at
As microprocessor passes through general-purpose serial bus USB and terminal data transmission.
The microcirculation detection method that Electrophysiology detection device is imaged based on microcirculation of the present invention, specific method is such as
Under：
1) human foot microcirculation characteristic standard database is established, and by the database purchase in terminal；
2) terminal determines LED near-infrared light source light intensity distribution matrixs, and is imaged microprocessor by microcirculation
Device controls LED near-infrared light sources and irradiates human foot；
3) near-infrared camera acquisition human foot reflected light image, and be transmitted to microcirculation imaging microprocessor and gone
Noise processed；
4) terminal is produced according to the obtained noise reduction human foot reflected light image extraction human foot blood of step 3
The luminance information of raw image；
5) luminance information for the image that terminal is generated according to the obtained human foot blood of step 4 calculates blood
Content simultaneously obtains the blood content and irradiation light intensity relative value；
6) terminal calculates separately the corresponding blood content of LED near-infrared light sources and irradiation light of two kinds of wavelength
Strong relative value and value；
7) terminal calculates separately the corresponding blood content of LED near-infrared light sources and irradiation light of two kinds of wavelength
The ratio of strong relative value；
8) terminal is by step 6 and value and ratio and the human foot microcirculation characteristic standard number in step 7
The microcirculation feature of irradiated site is relatively obtained according to data in library.
The beneficial effects of the invention are as follows：The application is easy to operate, need not take a blood sample, avoid when carrying out diabetes detection
Blood sampling wound is not easy to heal and then cause the possibility of infection, reduces 95% or more infection probability, and the repeatable profit of instrument
With.
Description of the drawings
Fig. 1 is that the microcirculation of the present invention is imaged the circuit modular structure figure of Electrophysiology detection device；
Fig. 2 is the circuit module that the microcirculation of the present invention is imaged the stimulus signal processing circuit of Electrophysiology detection device
Structure chart；
Fig. 3 is the circuit module that the microcirculation of the present invention is imaged the skin electrical signal detection circuit of Electrophysiology detection device
Structure chart；
Fig. 4 is the circuit structure that the microcirculation of the present invention is imaged the stimulus signal processing circuit of Electrophysiology detection device
Figure；
Fig. 5 is the circuit structure that the microcirculation of the present invention is imaged the skin electrical signal detection circuit of Electrophysiology detection device
Figure；
Fig. 6 is that the microcirculation of the present invention is imaged the peripheral nerve detection device detection waveform figure of Electrophysiology detection device
As example.
Specific implementation mode
Specific implementation mode one
The microcirculation of the present invention is imaged Electrophysiology detection device, including peripheral nerve detection device 1 and microcirculation at
As device 13, peripheral nerve detection device 1 includes stimulating electrode 2, stimulus signal processing circuit 3, detecting electrode 4, skin electric signal
Detection circuit 5 and peripheral nerve detect microprocessor 6；
Stimulus signal processing circuit 3 includes isolating amplifier circuit 7 and current-to-voltage converting circuit 8, and stimulus signal isolation is put
The voltage signal output end of the voltage signal inputs electrical connection peripheral nerve detection microprocessor 6 of big circuit 7, isolation amplification
Voltage signal inputs, the Current Voltage of the voltage amplification signal output end electrical connection current-to-voltage converting circuit 8 of circuit 7 turn
Change the current output terminal electrical connection stimulating electrode 2 of circuit 8；
Skin electrical signal detection circuit 5 includes pre-amplification circuit 9, filter circuit 10, detection signal isolation amplifying circuit 11
With processor interface circuit 12, current signal input electrical connection detecting electrode 4, the preposition amplification electricity of pre-amplification circuit 9
The current signal input of the amplification current signal output end electrical connection filter circuit 10 on road 9, the electric current letter of filter circuit 10
The amplification of number output end electrical connection detection signal isolation amplifying circuit 11 current input terminal, detection signal isolation amplifying circuit 11
Current output terminal is electrically connected the voltage signal output of the current input terminal of processor interface circuit 12, processor interface circuit 12
The voltage signal inputs of end electrical connection peripheral nerve detection microprocessor 6.
Function of peripheral nerves testing principle：It is to apply specific impulse stimulation to hand or foot by stimulating electrode 2 to believe
Number (electric current 50mA to 100mA, pulse width 0.1mS to 0.2mS), then by detect the voltage waveform that arch of the foot and the palm of the hand generate come
Surroundings thereof's nerves reaction is observed, whether function is normal for the waveforms detection peripheral nerve reacted by peripheral nerve.
As shown, in regular hour t by the amplitude A of voltage waveform come detect peripheral nerve whether function just
Often.
Peripheral nerve detection microprocessor 6 passes through general-purpose serial bus USB and terminal transmission data.As voltage is believed
Number value, and by computer carry waveform show Software on Drawing go out time t and voltage amplitude A relationship waveform.
Microcirculation imaging device 13 includes that near-infrared video camera 14, LED near-infrared light sources 15 and microcirculation are imaged microprocessor
Device 16；
LED near-infrared light sources 15, the LED near-infrared light sources for emitting two kinds of different wave lengths irradiate human foot respectively；
Near-infrared video camera 14 acquires reflected light image caused by LED near-infrared light sources irradiation human foot, near-infrared
The image input of the output end of image connection microcirculation imaging microprocessor 16 of video camera 14.
Microcirculation, which is imaged microprocessor 16, can also use STM32F409 microcontrollers, or can be detected with peripheral nerve
Microprocessor 6 shares.
Microcirculation, which is imaged between microprocessor 16 and LED near-infrared light sources 15 and near-infrared video camera 14, is equipped with control electricity
Road, the control circuit can control the illumination zone of LED near-infrared light sources 15, illumination intensity, and control near-infrared video camera 14 is burnt
Away from etc..
Microcirculation imaging microprocessor 16 passes through general-purpose serial bus USB and terminal data transmission.Computer is whole
End storage it is existing have the function of light intensity distribution matrix control function, image noise reduction, image luminance information abstraction function with
And according to softwares such as the functions of Blood Image brightness calculation blood content, for controlling irradiation light intensity and being carried out to reflected light image
Noise reduction extracts brightness of image and calculates blood content etc. according to brightness of image.
Specific implementation mode two
Difference lies in stimulus signal isolating amplifier circuit 7 includes present embodiment two with specific implementation mode one
Amplifier A1, resistance R1, resistance R2 and isolated amplifier IC1；
The in-phase input end of amplifier A1 is electrically connected the digital-to-analog that peripheral nerve detects microprocessor 6 by resistance R1
Signal output end, inverting input are electrically connected output end by negative feedback resistor R2, output end is electrically connected isolated amplifier
The in-phase input end of IC1, the anti-phase input termination of isolated amplifier IC1 (5000V isolation amplification) is digitally.
Stimulus signal isolating amplifier circuit 7 is by isolated amplifier IC1 to detecting what microprocessor 6 exported from peripheral nerve
Pulse is amplified.
Specific implementation mode three
Difference lies in current-to-voltage converting circuit 8 includes amplifier to present embodiment three with specific implementation mode two
A2, amplifier A3, resistance R3, resistance R4, negative feedback resistor R5, resistance R6, resistance R7, resistance R8, resistance R9, triode Q1 and two
A stimulating electrode 2；
The inverting input of amplifier A2 is electrically connected isolated amplifier positive output end by resistance R3 respectively and by negative
Feedback resistance R5 electrically couples the output end of amplifier A2, and the in-phase input end of amplifier A2 passes through resistance R4 electrical connection isolation respectively
Amplifier negative output terminal and by resistance R6 connect simulation ground；The in-phase input end of amplifier A3 is electrically connected amplifier by resistance R7
The output end of A2, inverting input by resistance R9 connect digitally, output end pass through the base that resistance R8 is electrically connected triode Q1
Pole；Reversed-phase output, the collector of the emitter electrical connection amplifier A3 of triode Q1 is electrically connected one of stimulating electrode
2, another stimulating electrode 2 ground connection.
The voltage signal amplified to stimulus signal isolating amplifier circuit 7 is converted, and being converted to electric current, (impulse stimulation is believed
Number), and be applied on human body by stimulating electrode 2.
Specific implementation mode four
Difference lies in pre-amplification circuit 9 includes amplifier A4, fortune to present embodiment four with specific implementation mode three
Put A5, amplifier A6, amplifier A7, amplifier A8, resistance R10, resistance R11, resistance R12, negative feedback resistor R13, negative feedback resistor R14
With three detecting electrodes 4；
The in-phase input end of amplifier A4 is electrically connected first detecting electrode 4, output end and is electrically connected anti-phase input respectively
The in-phase input end of end and amplifier A7；The in-phase input end of amplifier A6 is electrically connected second detecting electrode 4, output end difference
It is electrically connected inverting input and the in-phase input end of amplifier A8；Amplifier A5 in-phase input ends are electrical by resistance R10 respectively
The output end of connection amplifier A4, output end, the amplifier A5 output ends that amplifier A6 is electrically connected by resistance R11 are electrically connected respectively
Inverting input and third root detecting electrode 4；The inverting input of amplifier A7 passes through negative feedback resistor R13 electrical connection fortune respectively
It puts the output end of A7, electrically couple amplifier A8 inverting inputs by resistance R12；The inverting input negative feedback resistor of amplifier A8
R14 is electrically connected the output end of amplifier A8 and the output termination simulation ground of amplifier A8.
Pre-amplification circuit 9 is used to detect the weak current that arch of the foot and the palm of the hand generate and carries out preposition amplification.
Specific implementation mode five
Difference lies in filter circuit includes low-pass filter circuit 18 to present embodiment five with specific implementation mode four
With high-pass filtering circuit 12；
Low-pass filter circuit 18 includes capacitance C1, capacitance C2, capacitance C3, resistance R15, resistance R16, resistance R17 and amplifier
A9；Output end, the other end of one end electrical connection amplifier A7 of resistance R15 is sequentially connected in series resistance R16 and resistance R17, resistance R17
Other end electrical connection amplifier A9 in-phase input end；Simulation ground, electricity are connect by capacitance C1 between resistance R15 and resistance R16
It is electrically connected the output end of the inverting input and amplifier A9 of amplifier A9 between resistance R16 and resistance R17 respectively by capacitance C2；
High-pass filtering circuit 12 includes capacitance C4, capacitance C5, capacitance C6, resistance R18, resistance R19, resistance R20 and amplifier
A10；
Output end, the other end of one end electrical connection amplifier A9 of capacitance C4 is sequentially connected in series capacitance C5 and capacitance C6, capacitance
The in-phase input end of the other end electrical connection amplifier A10 of C6；Simulation ground is connect by resistance R18 between capacitance C4 and capacitance C5,
It is electrically connected the output of the inverting input and amplifier A10 of amplifier A10 between capacitance C5 and capacitance C6 respectively by resistance R19
End.
The electric current to come is conveyed to pre-amplification circuit 9 and carries out high pass and low-pass filtering, filters off clutter.
Specific implementation mode six
Difference lies in 11 resistance of detection signal isolation amplifying circuit with specific implementation mode five for present embodiment six
R21, resistance R22, resistance R23, resistance R24, amplifier A11 and isolated amplifier IC2 (5000V isolation amplification)；
The in-phase input end of amplifier A11 is electrically connected the output end of amplifier A10 by resistance R22 respectively, passes through resistance R24
Connect simulation ground；The inverting input of amplifier A11 connects simulation ground by resistance R21 respectively, is electrically connected amplifier by resistance R23
The output end of A11；The in-phase input end of the output end electrical connection isolated amplifier IC2 of A11, the reverse phase of isolated amplifier IC2
Input termination simulation ground.
Detection signal isolation amplifying circuit 11 is for amplifying filtered current signal.
Specific implementation mode seven
Difference lies in processor interface circuit 12 includes resistance to present embodiment seven with specific implementation mode six
R25, resistance R26, negative feedback resistor R27, resistance R28, resistance R29, resistance R30, amplifier A12, amplifier A13, diode D1 and
Diode D2；
The inverting input of amplifier A12 is electrically connected the positive output end of isolated amplifier IC2 by resistance R25 respectively, leads to
Cross the output end of negative feedback resistor R27 electrical connection amplifiers A12；The output end of amplifier A12 is electrically connected diode D1's respectively
The analog/digital conversion interface of cathode, the anode of diode D2 and peripheral nerve detection microprocessor 6, the anode of diode D1
Connect digitally, the cathode of diode D2 connect power Vcc 2；
The in-phase input end of amplifier A12 is electrically connected the negative output terminal of isolated amplifier IC2 by resistance R26 respectively, leads to
Cross the output end of resistance R28 electrical connection amplifiers A13；The inverting input of the output end electrical connection amplifier A13 of amplifier A13,
The in-phase input end of amplifier A13 meets power supply Vref by resistance R29 respectively, is connect digitally by resistance R30.
Processor interface circuit 12 is converted to voltage signal by the current signal that signal isolation amplifying circuit 11 amplifies is detected
And it is delivered to peripheral nerve detection microprocessor 6 and carries out processing generation detection waveform image.
Specific implementation mode eight
Difference lies in peripheral nerve detects microprocessor to present embodiment eight with specific implementation mode one, two or seven
Device 6 is STM32F409 microcontrollers.
Specific implementation mode nine
Difference lies in based on microcirculation imaging Electrophysiology inspection with specific implementation mode 1 for present embodiment nine
The specific method is as follows for the detection method of survey device：
1) human foot microcirculation characteristic standard database is established, and by the database purchase in terminal；
2) terminal determines LED near-infrared light source light intensity distribution matrixs, and is imaged microprocessor by microcirculation
Device 16 controls LED near-infrared light sources 15 and irradiates human foot；
3) near-infrared video camera 14 acquire human foot reflected light image, and be transmitted to microcirculation be imaged microprocessor 16 into
Row Denoising disposal；
4) terminal is produced according to the obtained noise reduction human foot reflected light image extraction human foot blood of step 3
The luminance information of raw image；
5) luminance information for the image that terminal is generated according to the obtained human foot blood of step 4 calculates blood
Content simultaneously obtains the blood content and irradiation light intensity relative value；
6) terminal calculates separately the corresponding blood content of LED near-infrared light sources and irradiation light of two kinds of wavelength
Strong relative value and value；
7) terminal calculates separately the corresponding blood content of LED near-infrared light sources and irradiation light of two kinds of wavelength
The ratio of strong relative value；
8) terminal is by step 6 and value and ratio and the human foot microcirculation characteristic standard number in step 7
The microcirculation feature of irradiated site is relatively obtained according to data in library.
Microcirculation image-forming principle：Using the LED near-infrared light sources of 2 kinds of different wave lengths after processing, it is respectively radiated to
Human foot, then by near-infrared camera acquisition to the foot reflected image of 2 kinds of different wave lengths, and 2 kinds of image datas are passed
It is sent to terminal.
The present invention one is to utilize near infrared light patient's check point, and check point is acquired using image capturing system
The images such as blood, the oxygen content of different wave length.Nerve ending perceptibility is carried out using stimulus signal device, neuron is tested simultaneously.
Entire detection process to patient need not inject drug, fanout free region, it is radiationless, without sense of discomfort.Second is that providing shadow for early diagnosis
Picture and data information：Lead to the generation of diabetes for diabetic, mainly caused by two big pathological changes, i.e. microcirculation
Function changes and nervous function lesion.It being capable of essence using detector near-infrared blood, oxygen image-forming principle and peripheral nerve testing principle
Realize the early detection of diabetes accurately, it is technologically advanced, detection is accurate, be the early detections of diabetes, early treatment and
It thoroughly cures and provides possibility.
Claims (9)
1. microcirculation is imaged Electrophysiology detection device, which is characterized in that including peripheral nerve detection device (1) and microcirculation
Imaging device (13), peripheral nerve detection device (1) include stimulating electrode (2), stimulus signal processing circuit (3), detecting electrode
(4), skin electrical signal detection circuit (5) and peripheral nerve detection microprocessor (6)；
Stimulus signal processing circuit (3) includes stimulus signal isolating amplifier circuit (7) and current-to-voltage converting circuit (8), stimulation
The voltage signal of the voltage signal inputs electrical connection peripheral nerve detection microprocessor (6) of signal isolation amplifying circuit (7)
The voltage amplification signal output end electrical connection current-to-voltage converting circuit (8) of output end, stimulus signal isolating amplifier circuit (7)
Voltage signal inputs, current-to-voltage converting circuit (8) current output terminal electrical connection stimulating electrode (2)；
Skin electrical signal detection circuit (5) includes pre-amplification circuit (9), filter circuit (10), detection signal isolation amplifying circuit
(11) and processor interface circuit (12), the current signal input electrical connection detecting electrode (4) of pre-amplification circuit (9),
The current signal input of the amplification current signal output end electrical connection filter circuit (10) of pre-amplification circuit (9), filtering
Circuit (10) current signal output end electrical connection detection signal isolation amplifying circuit (11) current input terminal, detection signal every
Current input terminal, the processor of amplification current output terminal electrical connection processor interface circuit (12) from amplifying circuit (11) connect
The voltage signal inputs of the voltage signal output end electrical connection peripheral nerve detection microprocessor (6) of mouth circuit (12)；
Peripheral nerve detection microprocessor (6) passes through general-purpose serial bus USB and terminal transmission data；
Microcirculation imaging device (13) includes that near-infrared video camera (14), LED near-infrared light sources (15) and microcirculation are imaged micro- place
Manage device (16)；
The LED near-infrared light sources that LED near-infrared light sources (15) are used to emit two kinds of different wave lengths irradiate human foot respectively；
Near-infrared video camera (14) acquires reflected light image caused by LED near-infrared light sources irradiation human foot；
The LED controls of the LED control signal input terminal electrical connection microcirculation imaging microprocessor (16) of LED near-infrared light sources (15)
Signal output end processed, the image input of the output end of image connection microcirculation imaging microprocessor (16) of near-infrared video camera (14)
End；Microcirculation imaging microprocessor (16) passes through general-purpose serial bus USB and terminal data transmission.
2. microcirculation according to claim 1 is imaged Electrophysiology detection device, which is characterized in that stimulus signal is isolated
Amplifying circuit (7) includes amplifier A1, resistance R1, resistance R2 and isolated amplifier IC1；
The in-phase input end of amplifier A1 is electrically connected the digital-to-analog letter that peripheral nerve detects microprocessor (6) by resistance R1
Number output end, inverting input pass through that negative feedback resistor R2 is electrically connected output end, output end is electrically connected isolated amplifier IC1
In-phase input end, isolated amplifier IC1 anti-phase input termination digitally.
3. microcirculation according to claim 2 is imaged Electrophysiology detection device, which is characterized in that Current Voltage is converted
Circuit (8) includes amplifier A2, amplifier A3, resistance R3, resistance R4, negative feedback resistor R5, resistance R6, resistance R7, resistance R8, resistance
R9, triode Q1 and two stimulating electrodes (2)；
The inverting input of amplifier A2 is electrically connected isolated amplifier IC1 positive output ends by resistance R3 respectively and by negative anti-
Feed resistance R5 electrically couples the output end of amplifier A2, and the in-phase input end of amplifier A2 is put by resistance R4 electrical connection isolation respectively
Big device IC1 negative output terminals and simulation ground is connect by resistance R6；The in-phase input end of amplifier A3 passes through resistance R7 electrical connection fortune
Put the output end of A2, inverting input by resistance R9 connect digitally, output end passes through resistance R8 and is electrically connected triode Q1's
Base stage；Reversed-phase output, the one of stimulation electricity of collector electrical connection of the emitter electrical connection amplifier A3 of triode Q1
Pole (2), another stimulating electrode (2) ground connection.
4. microcirculation according to claim 3 is imaged Electrophysiology detection device, which is characterized in that pre-amplification circuit
(9) include amplifier A4, amplifier A5, amplifier A6, amplifier A7, amplifier A8, resistance R10, resistance R11, resistance R12, negative feedback resistor
R13, negative feedback resistor R14 and three detecting electrodes (4)；
The in-phase input end of amplifier A4 is electrically connected first detecting electrode (4), output end and is electrically connected inverting input respectively
And the in-phase input end of amplifier A7；The in-phase input end of amplifier A6 is electrically connected second detecting electrode (4), output end difference
It is electrically connected inverting input and the in-phase input end of amplifier A8；Amplifier A5 in-phase input ends are electrical by resistance R10 respectively
The output end of connection amplifier A4, output end, the amplifier A5 output ends that amplifier A6 is electrically connected by resistance R11 are electrically connected respectively
Inverting input and third root detecting electrode (4)；The inverting input of amplifier A7 is electrically connected by negative feedback resistor R13 respectively
The output end of amplifier A7 electrically couples amplifier A8 inverting inputs by resistance R12；The inverting input negative-feedback electricity of amplifier A8
Hinder the output end of R14 electrical connection amplifiers A8 and the output termination simulation ground of amplifier A8.
5. microcirculation according to claim 4 is imaged Electrophysiology detection device, which is characterized in that filter circuit (10)
Including low-pass filter circuit (18) and high-pass filtering circuit (19)；
Low-pass filter circuit (18) includes capacitance C1, capacitance C2, capacitance C3, resistance R15, resistance R16, resistance R17 and amplifier A9；
Output end, the other end of one end electrical connection amplifier A7 of resistance R15 is sequentially connected in series resistance R16 and resistance R17, resistance R17's
The other end is electrically connected the in-phase input end of amplifier A9；Simulation ground, resistance are connect by capacitance C1 between resistance R15 and resistance R16
It is electrically connected the output end of the inverting input and amplifier A9 of amplifier A9 between R16 and resistance R17 respectively by capacitance C2；
High-pass filtering circuit (19) includes capacitance C4, capacitance C5, capacitance C6, resistance R18, resistance R19, resistance R20 and amplifier
A10；
Output end, the other end of one end electrical connection amplifier A9 of capacitance C4 is sequentially connected in series capacitance C5 and capacitance C6, capacitance C6's
The other end is electrically connected the in-phase input end of amplifier A10；Simulation ground, capacitance are connect by resistance R18 between capacitance C4 and capacitance C5
It is electrically connected the output end of the inverting input and amplifier A10 of amplifier A10 between C5 and capacitance C6 respectively by resistance R19.
6. microcirculation according to claim 5 is imaged Electrophysiology detection device, which is characterized in that detection signal isolation
Amplifying circuit (11) resistance R21, resistance R22, resistance R23, resistance R24, amplifier A11 and isolated amplifier IC2；
The in-phase input end of amplifier A11 is electrically connected the output end of amplifier A10 by resistance R22 respectively, connects mould by resistance R24
Quasi- ground；The inverting input of amplifier A11 connects simulation ground by resistance R21 respectively, is electrically connected amplifier A11's by resistance R23
Output end；The in-phase input end of the output end electrical connection isolated amplifier IC2 of A11, the inverting input of isolated amplifier IC2
Connect simulation ground.
7. microcirculation according to claim 6 is imaged Electrophysiology detection device, which is characterized in that processor interface electricity
Road (12) includes resistance R25, resistance R26, negative feedback resistor R27, resistance R28, resistance R29, resistance R30, amplifier A12, amplifier
A13, diode D1 and diode D2；
The inverting input of amplifier A12 is electrically connected the positive output end of isolated amplifier IC2, by negative by resistance R25 respectively
The output end of feedback resistance R27 electrical connection amplifiers A12；The output end of amplifier A12 be electrically connected respectively diode D1 cathode,
The analog/digital conversion interface of anode and peripheral nerve the detection microprocessor (6) of diode D2, the anode of diode D1 connect number
Word, the cathode of diode D2 connect power Vcc 2；
The in-phase input end of amplifier A12 is electrically connected the negative output terminal of isolated amplifier IC2 by resistance R26 respectively, passes through electricity
Hinder the output end of R28 electrical connection amplifiers A13；The inverting input of the output end electrical connection amplifier A13 of amplifier A13, amplifier
The in-phase input end of A13 meets power supply Vref by resistance R29 respectively, is connect digitally by resistance R30.
8. the microcirculation according to claim 1,2 or 7 is imaged Electrophysiology detection device, which is characterized in that surrounding god
Microprocessor (6) is STM32F409 microcontrollers after testing.
9. being imaged the microcirculation detection method of Electrophysiology detection device, feature based on microcirculation described in claim 1
It is, the specific method is as follows：
1) human foot microcirculation characteristic standard database is established, and by the database purchase in terminal；
2) terminal determines LED near-infrared light source light intensity distribution matrixs, and is imaged microprocessor by microcirculation
(16) control LED near-infrared light sources (15) irradiate human foot；
3) near-infrared video camera (14) acquire human foot reflected light image, and be transmitted to microcirculation imaging microprocessor (16) into
Row Denoising disposal；
4) terminal is generated according to the obtained noise reduction human foot reflected light image extraction human foot blood of step 3
The luminance information of image；
5) luminance information for the image that terminal is generated according to the obtained human foot blood of step 4 calculates blood content
And obtain the blood content and irradiation light intensity relative value；
6) terminal calculates separately the corresponding blood content of LED near-infrared light sources and irradiation light intensity phase of two kinds of wavelength
To value and value；
7) terminal calculates separately the corresponding blood content of LED near-infrared light sources and irradiation light intensity phase of two kinds of wavelength
To the ratio of value；
8) terminal is by step 6 and value and ratio and the human foot microcirculation characteristic standard database in step 7
Interior data relatively obtain the microcirculation feature of irradiated site.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810247145.XA CN108403104B (en) | 2018-03-23 | 2018-03-23 | Microcirculation imaging nerve electrophysiology detection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810247145.XA CN108403104B (en) | 2018-03-23 | 2018-03-23 | Microcirculation imaging nerve electrophysiology detection device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108403104A true CN108403104A (en) | 2018-08-17 |
| CN108403104B CN108403104B (en) | 2024-05-24 |
Family
ID=63133360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810247145.XA Active CN108403104B (en) | 2018-03-23 | 2018-03-23 | Microcirculation imaging nerve electrophysiology detection device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108403104B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109490735A (en) * | 2018-10-12 | 2019-03-19 | 上海谱幂精密仪器科技有限公司 | It is a kind of for measuring the device and method of electric current and/or voltage |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201404216Y (en) * | 2009-05-19 | 2010-02-17 | 王蓉 | Neural network reconstruction device |
| CN103584870A (en) * | 2013-10-30 | 2014-02-19 | 中南大学湘雅三医院 | Noninvasive hemoglobin tester and detection method thereof |
| CN203861234U (en) * | 2014-04-12 | 2014-10-08 | 吉林大学 | Near-infrared dual-wavelength noninvasive blood glucose gauge |
| US8868157B1 (en) * | 2011-11-09 | 2014-10-21 | VisionQuest Biomedical LLC | Thermal optical imager system and method for detection of peripheral neuropathy |
| CN104352230A (en) * | 2014-11-10 | 2015-02-18 | 电子科技大学 | Non-invasive thrombosis detector |
| CN204193306U (en) * | 2014-09-24 | 2015-03-11 | 杭州远想医疗设备有限公司 | A kind of novel peripheral neuropathy detector |
| CN204618246U (en) * | 2015-03-20 | 2015-09-09 | 华南师范大学 | A kind of non-contact vein blood oxygen saturation imaging device |
| CN105451640A (en) * | 2013-06-03 | 2016-03-30 | 南洋理工大学 | Systems and methods for pedal revascularization assessment |
| CN106170242A (en) * | 2014-03-31 | 2016-11-30 | 皇家飞利浦有限公司 | For lesion detection and/or the equipment of monitoring, system and method |
| CN106618548A (en) * | 2016-11-16 | 2017-05-10 | 施康培医疗科技（武汉）有限公司 | Body neuropathy automatic detection equipment and method |
| CN208725715U (en) * | 2018-03-23 | 2019-04-12 | 哈尔滨海鸿基业科技发展有限公司 | Electrophysiology detection device is imaged in microcirculation |
-
2018
- 2018-03-23 CN CN201810247145.XA patent/CN108403104B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201404216Y (en) * | 2009-05-19 | 2010-02-17 | 王蓉 | Neural network reconstruction device |
| US8868157B1 (en) * | 2011-11-09 | 2014-10-21 | VisionQuest Biomedical LLC | Thermal optical imager system and method for detection of peripheral neuropathy |
| CN105451640A (en) * | 2013-06-03 | 2016-03-30 | 南洋理工大学 | Systems and methods for pedal revascularization assessment |
| CN103584870A (en) * | 2013-10-30 | 2014-02-19 | 中南大学湘雅三医院 | Noninvasive hemoglobin tester and detection method thereof |
| CN106170242A (en) * | 2014-03-31 | 2016-11-30 | 皇家飞利浦有限公司 | For lesion detection and/or the equipment of monitoring, system and method |
| CN203861234U (en) * | 2014-04-12 | 2014-10-08 | 吉林大学 | Near-infrared dual-wavelength noninvasive blood glucose gauge |
| CN204193306U (en) * | 2014-09-24 | 2015-03-11 | 杭州远想医疗设备有限公司 | A kind of novel peripheral neuropathy detector |
| CN104352230A (en) * | 2014-11-10 | 2015-02-18 | 电子科技大学 | Non-invasive thrombosis detector |
| CN204618246U (en) * | 2015-03-20 | 2015-09-09 | 华南师范大学 | A kind of non-contact vein blood oxygen saturation imaging device |
| CN106618548A (en) * | 2016-11-16 | 2017-05-10 | 施康培医疗科技（武汉）有限公司 | Body neuropathy automatic detection equipment and method |
| CN208725715U (en) * | 2018-03-23 | 2019-04-12 | 哈尔滨海鸿基业科技发展有限公司 | Electrophysiology detection device is imaged in microcirculation |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109490735A (en) * | 2018-10-12 | 2019-03-19 | 上海谱幂精密仪器科技有限公司 | It is a kind of for measuring the device and method of electric current and/or voltage |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108403104B (en) | 2024-05-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4411273A (en) | System and method for electrode pair derivations in electroencephalography | |
| Prakash et al. | A compact-sized surface EMG sensor for myoelectric hand prosthesis | |
| CN101822863A (en) | Emotion regulating device and method thereof | |
| WO2006132958A2 (en) | Neurophysiological wireless bio-sensor | |
| CN208725715U (en) | Electrophysiology detection device is imaged in microcirculation | |
| CN204797851U (en) | Wearable many first physiological parameters of human inferior health spirit pressure analysis appearance | |
| WO2024031872A1 (en) | Motor neuromuscular vascular coupling function detection system | |
| CN201404215Y (en) | Portable minitype electromyography evoked potential instrument | |
| CN108403104A (en) | Microcirculation is imaged Electrophysiology detection device | |
| US8659297B2 (en) | Reducing noise in magnetic resonance imaging using conductive loops | |
| Kim et al. | HectoSTAR microLED optoelectrodes for large-scale, high-precision in invo opto-electrophysiology | |
| CN104523271B (en) | A kind of myoelectricity surveys pain device | |
| CN201968675U (en) | ARM (Advanced RISC Machine)-based body surface stomach electric signal collecting analyzer | |
| CN1233297C (en) | Gastrointestinal biological electric information tracking therapeutic instrument | |
| Toresano et al. | Data acquisition instrument for EEG based on embedded system | |
| CN2569743Y (en) | Domestic artificial intelligent electrocardiographic monitoring device combined with computer | |
| Brucal et al. | Development of a 12-Lead ECG Signal Processing Algorithm Using NI LabVIEW® and NI ELVIS® | |
| RU88932U1 (en) | DEVICE FOR RECORDING AND CORRECTION OF WAVE PROCESSES OF BIO OBJECTS | |
| US20120010859A1 (en) | Frequency physical carrier for diagnostics, medical therapy and human, zootechncal and agronomic enhancement | |
| RU2445067C2 (en) | Device for diagnosing patient's body state by acupuncture points | |
| CN116211298A (en) | System, method and sensor for integrating blood oxygen content and electric signal acquisition | |
| CN212679102U (en) | Detection simulation finger of blood oxygen saturation monitor | |
| CN109452937B (en) | Multifunctional human body electrophysiological simulation device and control method | |
| CN204428031U (en) | A kind of clinical myoelectricity surveys pain device | |
| CN201182599Y (en) | Multifocal visual electrophysiology equipment based on PC platform |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant |