CN108379373A - A kind of Chinese medicine preparation for treating paralysis - Google Patents

A kind of Chinese medicine preparation for treating paralysis Download PDF

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CN108379373A
CN108379373A CN201810426955.1A CN201810426955A CN108379373A CN 108379373 A CN108379373 A CN 108379373A CN 201810426955 A CN201810426955 A CN 201810426955A CN 108379373 A CN108379373 A CN 108379373A
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郭光俊
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238Saposhnikovia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/51Gentianaceae (Gentian family)
    • A61K36/515Gentiana
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

A kind of Chinese medicine preparation for treating paralysis, Chinese medicine material and weight ratio in being formulated are respectively:18 parts of RADIX ANGELICAE SINEINSIS fries 13 parts of rhizome of chuanxiong, 8 parts of Radix Gentianae Marcrophyllae, 7 parts of RADIX SAPOSHINOKOVIAE from Northeast, 5 parts of the full worm of salt, 7 parts of white bombys batryticatus, 16 parts of Rhizoma Atractylodis Macrocephalae, 14 parts of PORIA from Yunnan of China, 12 parts of citrus chachiensis hortorum, 10 parts of fresh ramulus cinnamomi.Raw medicinal material pharmacological property effect selected by the present invention is complementary, evaded the mutual inhibition of compatibility between drug, mutual restraint between two drugs, the mutual-detoxication choosing, make drug mutual reinforcement between, mutually make effect notable, have the function of removing obstruction in channels to relieve pain, for malicious dissipating bind, while having effects that liver protection decompression, prevention neurasthenia.

Description

A kind of Chinese medicine preparation for treating paralysis
Technical field
The present invention relates to the field of Chinese medicines, and in particular to and it is a kind of to remove obstruction in channels to relieve pain, treat the Chinese medicine preparation paralysed for malicious dissipating bind, Treating paralysis to help has effects that good liver protection decompression, prevention neurasthenia.
Background technology
Paralysis,(paralysis)It is the attenuating or forfeiture of voluntary motor function, is the common symptom of nervous system, is god Caused by, neuromuscular junction or muscle disease.All cortex movement projection areas and upper motor neurons pathway, spinal cord, surrounding god It is damaged by lesion through, neuromuscular junction or movement muscle itself, can cause to paralyse, the common cause of disease has outside cranium brain Wound, tumour, inflammation, cerebrovascular disease, denaturation, poisoning and the certain diseases of internal medicine, such as diabetes, hematoporphyria, macrocytic Anaemia and vitamin B12 deficiency etc..Necessary selective laboratory examination project includes:Blood routine, blood electrolyte, blood Sugar, urea nitrogen.Limitation of movement caused by certain diseases should be excluded first when judgement paralysis, as Parkinson's disease and other diseases cause Myotonia or bradykinesia or because limbs pain dare not activity etc..Lesion must be determined according to the symptom and sign of patient first Positioned at the specified level of neuromuscular system, it just can determine that the cause of disease of myasthenia, myasthenia are distributed to radiculopathy, plexopathy And the discriminating of peripheral nerve disease and neurogenic and muscle-derived lesion quite has benifit.Being directed to by etiological diagnosis causes arbitrarily to transport The protopathy of dynamic obstacle is treated.
Invention content
The present invention relates to the field of Chinese medicines, provide it is a kind of remove obstruction in channels to relieve pain, for malicious dissipating bind treatment paralysis Chinese medicine preparation, it is right Paralysis is treated in help has effects that good liver protection decompression, prevention neurasthenia.
Present invention employs the following technical solutions to achieve the above object:The medicinal material of Chinese medicine preparation selection of the present invention And parts by weight are respectively:18 parts of RADIX ANGELICAE SINEINSIS, fry 13 parts of rhizome of chuanxiong, 8 parts of Radix Gentianae Marcrophyllae, 7 parts of RADIX SAPOSHINOKOVIAE from Northeast, 5 parts of the full worm of salt, 7 parts of white bombys batryticatus, 16 parts of Rhizoma Atractylodis Macrocephalae, 14 parts of PORIA from Yunnan of China, 12 parts of citrus chachiensis hortorum, 10 parts of fresh ramulus cinnamomi.
In the Chinese medicine material that the present invention selects:
RADIX ANGELICAE SINEINSIS:【Chemical composition】Containing basic lactone, n-butene acyl lactone, ferulic acid, niacin, sucrose and a variety of amino acid, with And sesquiterpenoids etc..【Meridian distribution of property and flavor】It is warm-natured, it hides sweet, pungent.Return liver, the heart, the spleen channel.【Major function】Replenishing and activating blood is adjusted Meridian and relieving pain relaxes bowel.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, wind Arthritis with fixed pain caused by dampness pain, injury from falling down, ulcer sores.
Fry Rhizoma Chuanxiong:Rhizome of chuanxiong, acrid flavour are warm-natured.Return liver, courage, pericardium channel.【Function with cure mainly】Blood-activating and qi-promoting, wind-expelling pain-stopping.With In pacifying nerve, positive head wind headache, abdominal mass abdominal pain, chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.
Radix Gentianae Marcrophyllae:Bark of ash, alias:Gentiana macrophylla, great Ye bark of ash, RADIX GENTIANAE MACROPHYLLAE;Angiospermae, dicotyledon, rough gentian Section, Latin literary fame:G. macrophylla is Gentianaceae herbaceos perennial, is to control rheumatic arthritis, tuberculosis hectic fever, Huang One of main ingredients of diseases such as subcutaneous ulcer.
RADIX SAPOSHINOKOVIAE from Northeast:【Original shape classification】Dicotyledonous angiosperm, Umbelliferae, windproof category;Root and all herbal medicine, can wind dispelling town Bitterly, clearing heat and detoxicating, it controls by diseases such as wind headache, neurasthenia.
The full worm of salt:Full worm is the hirudo leech of full Buthidae animal, has Inflammation Zhijing, removes obstruction in channels to relieve pain, for the work(of malicious dissipating bind Effect.
White bombys batryticatus:Also known as stiff silkworm, flying worm.Muscardine is infected for the larva of Bombycidae animal bombyx mori and ossified full worm. The larva of a silkworm with batrytis contains lysine, leucine, 17 kinds of amino acid such as aspartic acid, 28 kinds of members such as magnesium, calcium, zinc containing protein, ammonium oxalate Element.Meridian distribution of property and flavor:Acrid flavour;It is salty;It is mild-natured.Return liver;Lung;Stomach.Effect:Expelling wind and relieving convulsion;Reducing phlegm and resolving masses;Removing toxic substances relieving sore-throat.It cures mainly:It is frightened Epilepsy is twitched;Apoplexy deviation of the mouth with numbness and paralysis;Migraine and general headache;Abscess of throat;Scrofula;Mumps;Rubella;Sore.
Rhizoma Atractylodis Macrocephalae:Rhizoma Atractylodis Macrocephalae perennial herb, is used as medicine with rhizome, has multinomial medicinal function.【Meridian distribution of property and flavor】Bitter, sweet, warm. Returns spleen, stomach.Effect:Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, tocolysis.For spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, water It is swollen, spontaneous perspiration, fetal irritability.
PORIA from Yunnan of China:It is one kind in Poria cocos Chinese medicine also known as cloud Siberian cocklebur.Source:For the drying bacterium of On Polyporaceae Poria cocos Core.The outer skin zone of this sclerotium of Poria cocos(Fuling peel), Jin Wai skin zones light red color part(Poria cocos), entertain pine stump among sclerotium (That is " indian bread hostwood ")White portion(Fushen)Hyoscine.Meridian distribution of property and flavor:It is sweet, light, it puts down.The thoughts of returning home, lung, spleen, kidney channel.Effect:It oozes Wet Li Shui;Strengthening the spleen and stomach;Antitoxic heart-soothing and sedative.It cures mainly:Difficult urination;Oedema turgor;Phlegm and retained fluid cough is inverse;Vomiting;Spleen eating less;Diarrhea; Palpitation and restlessness;Insomnia forgetfulness;Seminal emission gonorrhoea.
Citrus chachiensis hortorum:Dried orange peel contains hesperidine about 8.4%, Nobiletin(nobiletin)About 0.15%. separately contains synephrine(To hydroxyl Forint)0.28%-2.54%.【Attending effectiveness】:Regulating qi-flowing for strengthening spleen, in tune, eliminating dampness, resolving sputum.It cures mainly:The abdominal fullness and distention of the taste stagnation of the circulation of vital energy or Pain, indigestion.Abdominal distension uncomfortable in chest, indigestion and loss of appetite loose stool in wet turbid resistance.The cough and asthma of phlegm obstructing lung.For chest gastral cavity turgor, food It is few to vomit and diarrhoea, coughing with a lot of sputum.
Fresh ramulus cinnamomi:For the dry twig of Lauraceae aiphyllium plant Chinese cassia tree.【It cures mainly】Expelling cold and relieving exterior syndrome;Warming meridian;It activates yang Change gas.Main exterior syndrome due to wind-cold;Numbness and ache of cold dampness;Peripheral coldness;Closed dysmenorrhea;Abdominal mass caking;The obstruction of qi in the chest;Palpitaition;Phlegm and retained fluid;Difficult urination. For anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, joint pain, phlegm and retained fluid, oedema, palpitaition, run quickly globefish.【Effect】Sweating expelling pathogenic factors from muscles and skin, temperature Through promoting blood circulation, helps yang transforming qi, eliminating cold to stop pain.Raw medicinal material pharmacological property effect selected by the present invention is complementary, has evaded compatibility between drug The mutual inhibition, mutual restraint between two drugs, the mutual-detoxication choosing, make drug mutual reinforcement between, mutually make effect notable, have improve immunity, tonifying spleen and kidney, qi and activate blood circulation The effect of.
The present invention's removes obstruction in channels to relieve pain, for the Chinese medicine preparation for treating paralysis of malicious dissipating bind, and treating paralysis to help has well Liver protection decompression, prevention neurasthenia the effect of;It is for oral administration, by clinical application, achieve unexpected promising result.
Specific implementation mode
A kind of Chinese medicine preparation for treating paralysis, the Chinese medicine material and parts by weight of selection are respectively:18 parts of RADIX ANGELICAE SINEINSIS fries rhizome of chuanxiong 13 parts, 8 parts of Radix Gentianae Marcrophyllae, 7 parts of RADIX SAPOSHINOKOVIAE from Northeast, 5 parts of the full worm of salt, 7 parts of white bombys batryticatus, 16 parts of Rhizoma Atractylodis Macrocephalae, 14 parts of PORIA from Yunnan of China, citrus chachiensis hortorum 12 Part, 10 parts of fresh ramulus cinnamomi.Preparation method is:
Step 1:By RADIX ANGELICAE SINEINSIS, fry rhizome of chuanxiong, Radix Gentianae Marcrophyllae, RADIX SAPOSHINOKOVIAE from Northeast, the full worm of salt, white bombys batryticatus, Rhizoma Atractylodis Macrocephalae, PORIA from Yunnan of China, citrus chachiensis hortorum, The Chinese medicine materials such as fresh ramulus cinnamomi are picked, are dried respectively, mix after it is spare;
Step 2:By step(One)Gains smash it through 800 sieves, add ethanolic aqueous system as solvent, and obtained by 2h carries It takes liquid, water-bath ethanol evaporation to obtain Chinese medicine extract, sterilizes, stand to room temperature and get product.
Clinical drug observation of the present invention:
Accept out-patient totally 39 for medical treatment, age 20-30 Sui 5,31-40 Sui 8,41-50 Sui 20,50 years old or more 6.39 After patient medication, all cure.
Case 1:Week certain, man, building site worker causes the lower part of the body to lose locomotor activity substantially caused by work, the soft inability of foot, It sleeps bad, loses the appetite, long-term sitting posture causes to have a pain in the back, tinnitus, and pale tongue with white fur is worn out mentally and physically.Laboratory blood examination blood is normal Rule, blood electrolyte, blood glucose, urea nitrogen.Diagnosis:Neurasthenia, nerve or movement muscle changes, that is, paralyse.Therapy:Powdered medicine ' Tongluosan ' Knot, liver protection protect arteries and veins, separately assist recovery treating.With 14 doses of prescription of the present invention is thrown, take daily 1 dose, sooner or later point 2 decoctions, before meals after Half an hour takes.With examining later.Symptom is obviously improved, laboratory blood examination blood routine, blood electrolyte, blood glucose, urea nitrogen.Following the service 36 A course for the treatment of, legs and feet can assist walking.It is enjoined, two courses for the treatment of of continual cure consolidate curative effect.Take several doses i.e. more.
Case 2:Lee, man, 40 years old, sleep was bad, loss of appetite, tinnitus, and pale tongue with white fur is paralysed 1 year, and the lower part of the body is basic Lose locomotor activity.Therapy:Activating collaterals and eliminating stagnation, liver protection protect arteries and veins, separately assist recovery treating.With 14 doses of prescription of the present invention is thrown, 1 is taken daily Agent, point 2 decoctions sooner or later, half an hour after is taken before meals.36 courses for the treatment of of following the service, legs and feet can assist walking.It is enjoined, continual cure Two courses for the treatment of consolidate curative effect.Take several doses i.e. more.
Case 3:Fourth, man 65 years old, paralyse 5 years, the lower part of the body loses locomotor activity substantially.Therapy:Activating collaterals and eliminating stagnation, liver protection Arteries and veins is protected, recovery treating is separately assisted.With 14 doses of prescription of the present invention is thrown, 1 dose is taken daily, sooner or later point 2 decoctions, half an hour after takes before meals With.48 courses for the treatment of of following the service, legs and feet can assist walking.It is enjoined, two courses for the treatment of of continual cure consolidate curative effect.Take several doses i.e. more.
Case 4:Zhao, female 45 years old, paralyse half a year, and the lower part of the body loses locomotor activity substantially.Therapy:Activating collaterals and eliminating stagnation, liver protection Arteries and veins is protected, recovery treating is separately assisted.With 14 doses of prescription of the present invention is thrown, 1 dose is taken daily, sooner or later point 2 decoctions, half an hour after takes before meals With.36 courses for the treatment of of following the service, legs and feet can assist walking.It is enjoined, two courses for the treatment of of continual cure consolidate curative effect.Take several doses i.e. more.
The results show:A kind of pure Chinese medicine Zhitan preparation of the present invention, it is nonirritant to personal body, have bright Aobvious strong bone of allaying one's hunger increases the effect of blood vessel elasticity.

Claims (2)

1. a kind of Chinese medicine preparation for treating paralysis, which is characterized in that Chinese medicine material and parts by weight in formula are respectively:RADIX ANGELICAE SINEINSIS 18 parts, fry 13 parts of rhizome of chuanxiong, 8 parts of Radix Gentianae Marcrophyllae, 7 parts of RADIX SAPOSHINOKOVIAE from Northeast, 5 parts of the full worm of salt, 7 parts of white bombys batryticatus, 16 parts of Rhizoma Atractylodis Macrocephalae, PORIA from Yunnan of China 14 Part, 12 parts of citrus chachiensis hortorum, 10 parts of fresh ramulus cinnamomi.
2. a kind of preparation method of Chinese medicine preparation for treating paralysis described in accordance with the claim 1, which is characterized in that including following Step:
Step 1:RADIX ANGELICAE SINEINSIS is taken by part, fries rhizome of chuanxiong, Radix Gentianae Marcrophyllae, RADIX SAPOSHINOKOVIAE from Northeast, the full worm of salt, white bombys batryticatus, Rhizoma Atractylodis Macrocephalae, PORIA from Yunnan of China, wide old Skin, fresh ramulus cinnamomi Chinese medicine material, picked, dried respectively, mix after it is spare;
Step 2:Step 1 gains are smashed it through into 800 sieves, add ethanolic aqueous system as solvent, by the obtained extraction of 2h Liquid, water-bath ethanol evaporation obtain Chinese medicine extract, and sterilizing stands to room temperature and gets product.
CN201810426955.1A 2018-05-07 2018-05-07 A kind of Chinese medicine preparation for treating paralysis Pending CN108379373A (en)

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