CN108375556A - A kind of new type of high sensitivity and the unmarked Terahertz sensor for measuring monolayer - Google Patents
A kind of new type of high sensitivity and the unmarked Terahertz sensor for measuring monolayer Download PDFInfo
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- CN108375556A CN108375556A CN201810038539.4A CN201810038539A CN108375556A CN 108375556 A CN108375556 A CN 108375556A CN 201810038539 A CN201810038539 A CN 201810038539A CN 108375556 A CN108375556 A CN 108375556A
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- terahertz sensor
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- 230000035945 sensitivity Effects 0.000 title claims abstract description 23
- 239000002356 single layer Substances 0.000 title claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 14
- 239000010410 layer Substances 0.000 claims abstract description 13
- 239000002052 molecular layer Substances 0.000 claims abstract description 12
- 238000001514 detection method Methods 0.000 claims abstract description 5
- 230000000737 periodic effect Effects 0.000 claims abstract description 5
- 230000001413 cellular effect Effects 0.000 claims abstract description 4
- 238000010276 construction Methods 0.000 claims abstract description 4
- 230000010287 polarization Effects 0.000 claims abstract description 4
- 239000000126 substance Substances 0.000 claims abstract description 4
- 239000000758 substrate Substances 0.000 claims description 7
- 229910052751 metal Inorganic materials 0.000 claims description 6
- 239000002184 metal Substances 0.000 claims description 6
- 239000004642 Polyimide Substances 0.000 claims description 5
- 229920001721 polyimide Polymers 0.000 claims description 5
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052737 gold Inorganic materials 0.000 claims description 4
- 239000010931 gold Substances 0.000 claims description 4
- 239000010936 titanium Substances 0.000 claims description 4
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- 229910052709 silver Inorganic materials 0.000 claims description 3
- 239000004332 silver Substances 0.000 claims description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 2
- 239000011133 lead Substances 0.000 claims description 2
- 150000002739 metals Chemical class 0.000 claims description 2
- 238000011896 sensitive detection Methods 0.000 abstract description 2
- 238000013461 design Methods 0.000 description 11
- 238000005259 measurement Methods 0.000 description 10
- 238000001328 terahertz time-domain spectroscopy Methods 0.000 description 4
- 238000000411 transmission spectrum Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007769 metal material Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention discloses a kind of new type of high sensitivity and the unmarked Terahertz sensor for measuring monolayer, include the double-deck Meta Materials of periodic structure, the cellular construction of the periodic structure is the orthogonal two splittings ring of opening polarization direction.The invention also discloses a kind of methods that above-mentioned Terahertz sensor is used for the detection of biologic single molecular layer, and one layer of monolayer substance is covered in the side of the Terahertz sensor.The present invention realizes highly sensitive detection unmarked to biologic single molecular layer.
Description
Technical field
The present invention relates to a kind of Terahertz sensor, more particularly to a kind of new type of high sensitivity and unmarked measurement unimolecule
The Terahertz sensor of layer.
Background technology
The method of currently used research molecular characterization, is to carry out fluorescent marker to molecule, recycles streaming instrument to label
Molecule measure.This method is destructive, cannot continuously be observed the dynamic process of biomolecule.And valence
Lattice are expensive, and time-consuming.The unmarked measurement of biomolecule has many advantages, such as that quick, cost is small, lossless and can abandon, highly sensitive
Unmarked measurement is the target that life scientist is pursued always.
Unmarked highly sensitive detection is may be implemented using the optical microcavity of high quality factor, its high sensitivity can be with
Perceive the variation of monolayer.But this method thermal stability is poor, prepare it is complex, and optical microcavity be stereochemical structure not
It preferably integrates, these disadvantages cause it to be difficult to be applied in practice.THz wave has photon energy low, does not have to biomolecule
There are ionising effects；The vibration of biomolecule and rotational energy level are fallen in terahertz wave band, can there is absorption spectral property；And terahertz
Hereby wave can be by the strong absorption of water；Therefore with biomolecule very strong interaction can occur for THz wave, also illustrate too
Hertz wave is the wave band for being very suitable for studying biological molecular electromagnetic characteristic.
Carrying out the unmarked measurement of biomolecule using THz wave, there are three types of methods, first, according to the super of perturbation method design
Structure material, the sensitivity measured at present are at 50GHz/RIU/ μm（RIU, Refractive Index Unit indicate unit
Variations in refractive index）, second method is to be based on surface phasmon, its measurement sensitivity is suitable with the method for metamaterial.
The third method is the principles of internal reflection using prism, and sensitivity will be less than both above method.Due to the thickness of monolayer
Spend very little（10nm or so）, in order to measure the variation of monolayer, need sensor that there is very high sensitivity.It is above-mentioned at present
The sensitivity of method is all too low, is not enough to the variation for measuring monolayer.
Invention content
Goal of the invention：Existing problem and shortage for the above-mentioned prior art, the object of the present invention is to provide one kind to have
It is highly sensitive, can the unmarked Terahertz sensor for measuring biologic single molecular layer design scheme, and for single point of biology
The scheme of the high-sensitivity measurement of sublayer sensing identification.
Technical solution：For achieving the above object, the first technical solution that the present invention uses is a kind of novel Gao Ling
Sensitivity and the unmarked Terahertz sensor for measuring monolayer, include the double-deck Meta Materials of periodic structure（Artificial electromagnetic medium,
English is metamaterial）, the cellular construction of the periodic structure is the orthogonal two splittings ring of opening polarization direction
(splitting ring resonators, be abbreviated as SRRs).Utilize Space-Time title property point（Also known as singular point, English are
Exceptional Point, are abbreviated as EP）The size for locating the resonant frequency splitting of resonant cavity is very sensitive to external disturbance
Characteristic realizes the detection to external environment minor change.
Further, the centre of the double-deck Meta Materials is medium substrate film.
Further, the medium is polyimides.
Further, the thickness of the medium substrate film is 5 μm.
Further, the material of described two splitting rings is metal.
Further, the material of described two splitting rings is that two kinds of conductivity differ two kinds of larger metals, is differed here
Larger standard is ten times of difference or more.
Further, the material of described two splitting rings is respectively gold and titanium or silver and lead.
Second of technical solution that the present invention uses for by Terahertz sensor as described above be used for biologic single molecular layer
The method of detection, which is characterized in that cover one layer of monolayer substance in the side of the Terahertz sensor.What is provided is humorous
Vibration frequency splitting value arrives greatly 5GHz, it is sufficient to be measured with terahertz time-domain spectroscopy system.
Advantageous effect：The Terahertz sensor that the present invention designs is constituted compared to previous as a result, using two kinds of metal materials
It the double-deck Meta Materials and is operated near EP, sensitivity is very high, and the unmarked measurement of biologic single molecular layer may be implemented.
Description of the drawings
Fig. 1 is stereogram, front view and the side view of Terahertz sensor unit structure of the present invention.
Fig. 2 is to cover the transmission spectrum calculated after one layer of monolayer.
Specific implementation mode
In the following with reference to the drawings and specific embodiments, the present invention is furture elucidated, it should be understood that these embodiments are merely to illustrate
The use scope of the present invention rather than the limitation present invention, after having read the present invention, those skilled in the art are to the present invention
The modifications of various equivalent forms fall within the application range as defined in the appended claims.One, highly sensitive, can be without mark
Note measures the design scheme of the Terahertz sensor of biologic single molecular layer
According to Terahertz sensor structure design and simulation as shown in Figure 1, cellular construction is that two opening polarization directions are mutual
Vertical SRR rings are placed in the both sides of dielectric layer.Two SRR rings of both sides are made of gold and titanium respectively, and design parameter is a g1=5, g2= 4.31, d1=d2=20, p=50, s=9, the width of two SRR rings is all 5.Intermediate Jie
Matter layer is polyimides（English is Polyimide, is abbreviated as PI）, thickness 5, select this material to be in order to later real
Test the realizability of work.By adjusting the size of one of ring, parity-time may be implemented in we（English is parity-
Time is abbreviated as PT）Symmetry, and PT points are also a kind of singular point（EP）.Current design and other work ratios, are us
The metal material of two kinds of conductivity difference biggers is selected, it is more convenient in this way to realize PT points.Another bigger is not both present
Two SRR rings split the upper and lower surface in substrate.This is because when two SRR rings are in approximately the same plane, there is dielectric layer covering
When on the surface, when two resonators are disturbed simultaneously, lead to spectral line only overall frequency shift, be not in splitting, because up to not
To the purpose for improving sensing sensitivity.
When specific implementation, as long as two kinds of conductivity differences of the material of two SRR rings of both sides are larger（General difference
About ten times or more）Metal just, in addition to gold and titanium, can also be silver and lead.
Two, highly sensitive, unmarked Terahertz sensor is used for the scheme of biologic single molecular layer detection
It is to cover one layer of monolayer substance in the side of the Terahertz sensor, with terahertz time-domain spectroscopy systematic survey institute
State the transmitted spectrum of Terahertz sensor.
Three, highly sensitive, can the unmarked Terahertz sensor for measuring biologic single molecular layer result and discussion
High sensitivity that the present invention designs, can the unmarked most important application of Terahertz sensor for measuring biologic single molecular layer
Aspect is exactly the sensing measurement of biomolecule.Fig. 2 is the Terahertz transmission spectrum covered after one layer of monolayer.The list of emulation
Molecular layers thick is 10nm.We first assume that the refractive index of molecular layer is 1 in simulations, then change its refractive index again, point
Its transmission spectrum is not calculated, to obtain the variation of frequency in the presence of having molecular layer.It can be seen from the figure that when being refracted as 2,
Its frequency variation reaches 16 GHz, is much larger than terahertz time-domain spectroscopy system（English is Terahertz Time Domain
Spectroscopy is abbreviated as TDS）Frequency resolution, this further demonstrates that our design can be used for biologic single molecular
The unmarked measurement of layer.
In short, the Terahertz sensor for the double-layer structure that we design on polyimide substrate, being mainly reflected in can be with
The advantages of sensitivity, unmarked sensing measurement monolayer.It according to actual needs, can be into substrate thickness, metal structure parameter
Row optimization design can also obtain other frequencies, the higher Terahertz sensor of sensitivity.Therefore, it is widely used in Terahertz
In terms of sensing identification.
Claims (8)
1. a kind of new type of high sensitivity and the unmarked Terahertz sensor for measuring monolayer, which is characterized in that including the period
The cellular construction of the double-deck Meta Materials of structure, the periodic structure is the orthogonal two splittings ring of opening polarization direction.
2. a kind of new type of high sensitivity according to claim 1 and the unmarked Terahertz sensor for measuring monolayer,
It is characterized in that, the centre of the bilayer Meta Materials is medium substrate film.
3. a kind of new type of high sensitivity according to claim 2 and the unmarked Terahertz sensor for measuring monolayer,
It is characterized in that, the medium is polyimides.
4. a kind of new type of high sensitivity according to claim 2 and the unmarked Terahertz sensor for measuring monolayer,
It is characterized in that, the thickness of the medium substrate film is 5 μm.
5. a kind of new type of high sensitivity according to claim 1 and the unmarked Terahertz sensor for measuring monolayer,
It is characterized in that, the material of described two splitting rings is metal.
6. a kind of new type of high sensitivity according to claim 5 and the unmarked Terahertz sensor for measuring monolayer,
It is characterized in that, the material of described two splitting rings is that two kinds of conductivity differ two kinds of larger metals.
7. a kind of new type of high sensitivity according to claim 6 and the unmarked Terahertz sensor for measuring monolayer,
It is characterized in that, the material of described two splitting rings is respectively gold and titanium or silver and lead.
8. a kind of method that such as claim 1-7 any one of them Terahertz sensor is used for the detection of biologic single molecular layer,
It is characterized in that, covering one layer of monolayer substance in the side of the Terahertz sensor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810038539.4A CN108375556B (en) | 2018-01-16 | 2018-01-16 | Novel terahertz sensor for measuring monomolecular layer with high sensitivity and no mark |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810038539.4A CN108375556B (en) | 2018-01-16 | 2018-01-16 | Novel terahertz sensor for measuring monomolecular layer with high sensitivity and no mark |
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| Publication Number | Publication Date |
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| CN108375556A true CN108375556A (en) | 2018-08-07 |
| CN108375556B CN108375556B (en) | 2021-04-30 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109580535A (en) * | 2018-12-03 | 2019-04-05 | 上海理工大学 | For enhancing the metamaterial structure of THz wave detection tissue of biological cells signal |
| CN110031423A (en) * | 2019-05-23 | 2019-07-19 | 中国人民解放军陆军军医大学第一附属医院 | The method of unmarked assessment aquaporin function based on THz wave technology |
| CN111693494A (en) * | 2020-05-21 | 2020-09-22 | 西安理工大学 | CNTs (carbon nanotubes) super-surface-based THz wave sensor, preparation method and application thereof |
| CN113390819A (en) * | 2021-06-11 | 2021-09-14 | 西南科技大学 | Terahertz sensor |
| CN114047567A (en) * | 2021-06-22 | 2022-02-15 | 重庆大学 | Method for generating and regulating asymmetric surface plasmon mode |
| CN117554349A (en) * | 2024-01-11 | 2024-02-13 | 中国科学院苏州生物医学工程技术研究所 | Nano integrated optical chip for single molecule sensing and fluorescence detection method |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109580535A (en) * | 2018-12-03 | 2019-04-05 | 上海理工大学 | For enhancing the metamaterial structure of THz wave detection tissue of biological cells signal |
| CN109580535B (en) * | 2018-12-03 | 2021-04-30 | 上海理工大学 | Metamaterial structure for enhancing terahertz wave detection of biological cell tissue signals |
| CN110031423A (en) * | 2019-05-23 | 2019-07-19 | 中国人民解放军陆军军医大学第一附属医院 | The method of unmarked assessment aquaporin function based on THz wave technology |
| CN111693494A (en) * | 2020-05-21 | 2020-09-22 | 西安理工大学 | CNTs (carbon nanotubes) super-surface-based THz wave sensor, preparation method and application thereof |
| CN111693494B (en) * | 2020-05-21 | 2023-04-25 | 西安理工大学 | THz wave sensor based on CNTs super surface, preparation method and application thereof |
| CN113390819A (en) * | 2021-06-11 | 2021-09-14 | 西南科技大学 | Terahertz sensor |
| CN113390819B (en) * | 2021-06-11 | 2022-12-06 | 西南科技大学 | Terahertz sensor |
| CN114047567A (en) * | 2021-06-22 | 2022-02-15 | 重庆大学 | Method for generating and regulating asymmetric surface plasmon mode |
| CN114047567B (en) * | 2021-06-22 | 2023-07-18 | 重庆大学 | Asymmetric surface plasmon mode generation and regulation method |
| CN117554349A (en) * | 2024-01-11 | 2024-02-13 | 中国科学院苏州生物医学工程技术研究所 | Nano integrated optical chip for single molecule sensing and fluorescence detection method |
| CN117554349B (en) * | 2024-01-11 | 2024-03-19 | 中国科学院苏州生物医学工程技术研究所 | Nano integrated optical chip for single molecule sensing and fluorescence detection method |
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