CN108362534B - Multifunctional homogenizer - Google Patents
Multifunctional homogenizer Download PDFInfo
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- CN108362534B CN108362534B CN201810076570.7A CN201810076570A CN108362534B CN 108362534 B CN108362534 B CN 108362534B CN 201810076570 A CN201810076570 A CN 201810076570A CN 108362534 B CN108362534 B CN 108362534B
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- 238000000227 grinding Methods 0.000 claims abstract description 148
- 238000002156 mixing Methods 0.000 claims abstract description 26
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- 239000004576 sand Substances 0.000 claims description 8
- 210000001503 joint Anatomy 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 4
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 238000004554 molding of glass Methods 0.000 claims description 2
- 239000002002 slurry Substances 0.000 claims 3
- 238000000265 homogenisation Methods 0.000 abstract description 20
- 241001465754 Metazoa Species 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 11
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
- G01N2001/2866—Grinding or homogeneising
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Crushing And Grinding (AREA)
Abstract
The invention discloses a multifunctional homogenizer which comprises a homogenizing pipe and a homogenizing rod inserted in the homogenizing pipe, wherein the wall thickness of the bottom of the homogenizing pipe is larger than that of the side wall, the homogenizing pipe comprises an overflow preventing cavity, a coarse grinding cavity and a fine grinding cavity which are communicated with each other in a large upper part and a small lower part, a coarse and fine mixing positioning table is arranged between the coarse grinding cavity and the fine grinding cavity, the overflow preventing cavity is in a waist drum shape, the homogenizing rod comprises a rod body, a splash preventing cover and a grinding head which are arranged up and down, the cross section area of the splash preventing cover is smaller than the top opening of the overflow preventing cavity and larger than the outer diameter of the grinding head, and the grinding head comprises a coarse grinding section, a coarse and fine mixing switching surface and a fine grinding section which are arranged corresponding to the coarse grinding cavity, the coarse and fine mixing positioning table and the fine grinding cavity. According to the invention, the animal and plant tissues with larger quantity can be coarsely ground and coarsely and finely mixed ground under the required temperature condition according to the characteristics of the sample and the experimental requirements, and the tiny organisms with small quantity can be finely ground, so that various samples can quickly achieve the thorough homogenization effect, the homogenization effect is ideal, and the sample loss is small.
Description
Technical Field
The invention relates to a multifunctional homogenizer.
Background
In biological experiments, it is necessary to break up and disperse a biological sample into a homogeneous solution for measurement of a certain component, qualitative and quantitative analysis of chemical substances and pesticide residues in a living body. With the development of molecular biology, more and more experiments need to extract enzyme and DNA, RNA and other life active substances in animals and plants by homogenizing organisms or partial tissues for qualitative and quantitative comparison analysis. In order to maintain the biopolymer structure and activity in the tissue, it is necessary to homogenize the harvested animal and plant tissue under low temperature conditions. The homogenizer is a test device for grinding, crushing and dispersing various animal and plant tissue materials or samples in the fields of biology, medicine and the like to form a homogeneous homogenized liquid so as to carry out biological analysis and research. Is especially suitable for animal and plant samples which need low-temperature grinding and have small quantity.
The treated samples are plant, animal tissue, micro-organisms such as phytopathogenic nematodes in the maceration stage, entomopathogenic nematodes, mites and micro-tissues of organisms. The different types of organisms have different requirements on the homogenizer due to different analysis indexes, different volumes, different numbers and different homogenization treatment conditions. Laboratory generally uses mortar, glass homogenizer to grind samples, both of which have certain limitations on sample volume size: 1. the mortar is usually ground by liquid nitrogen grinding, so that a large amount of plant cell tissues or partial animal tissues are ground, and the small amount of samples are wasted due to the excessively large volume of the mortar, so that the quantity required for experimental detection is difficult to achieve. 2. The glass homogenizer is generally used for grinding a single tissue with small grinding amount, tiny organisms such as plant pathogenic nematodes, insect pathogenic nematodes, mites and the tiny tissues of organisms in the dip-dyeing stage, and has the advantages of insufficient grinding effect, easy splashing of grinding liquid and poor applicability.
Currently, there are many other types of homogenizers on the market, such as:
chinese patent No. zl201620178192.X discloses a manual homogenizer comprising a storage tube and a grinding rod, the grinding rod comprising a threaded section and a non-threaded section, a thread button being provided on the threaded section, the thread button being engaged with a thread on the threaded section and being movable along an axis in the threaded section. The defects are that: 1. the grinding rod and the storage tube are cylindrical, and the matching pair is higher, so that only biological tissues with small homogenization quantity and small quantity can be homogenized, and the samples are difficult to grind or insufficiently ground if the samples are slightly large. 2. In the homogenization process, the storage tube and the grinding gap are small, and the buffer solution is cylindrical, so that the poured buffer solution can float up a small amount of grinding sample, and the grinding is insufficient. 3. The thickness of the storage tube bottom is the same as that of the tube wall, and the tube bottom is easy to break when the homogenization is applied with force. 4. The top of the glass tube adopts a horn-shaped open shape, so that the homogenate cannot be poured into a target container in a concentrated manner, and the splashing waste is caused.
The Chinese patent with the patent number ZL 201010136673.1 discloses a hot melt adhesive micro-tissue homogenizer which consists of a pipe body and hammer wood inserted in the pipe, wherein the pipe body is made of a hot melt adhesive material, and the hammer body is a stainless steel hammer body. The defects are that: 1. the homogenizer is only suitable for homogenizing the micro biological tissues, and the grinding object is single. 2. The pipe body is made of hot melt adhesive material, and the hot melt adhesive material has small elasticity and has poor crushing effect on tiny plant tissues such as blades. 3. The tube body is opaque, and the grinding degree cannot be intuitively judged. 4. The hot melt adhesive material does not generate heat, but is difficult to conduct temperature, and biological high molecular structure and activity of biological samples with low temperature requirements during grinding cannot be completely ensured.
Disclosure of Invention
The invention aims to provide a multifunctional homogenizer which has the advantages of diversified sample selection, wide application range, full grinding effect, strong practicability and difficult splashing of homogenate.
The invention provides a multifunctional homogenizer which comprises a homogenizing pipe and a homogenizing rod inserted in the homogenizing pipe, wherein the wall thickness of the bottom of the homogenizing pipe is larger than that of the side wall, the homogenizing pipe comprises an overflow preventing cavity, a coarse grinding cavity and a fine grinding cavity which are communicated with each other in a large-small mode, a coarse and fine mixing positioning table is arranged between the coarse grinding cavity and the fine grinding cavity, the overflow preventing cavity is in a waist drum shape, the homogenizing rod comprises a rod body, a splash preventing cover and a grinding head which are arranged up and down, the cross section area of the splash preventing cover is smaller than the top opening of the overflow preventing cavity and larger than the outer diameter of the grinding head, and the grinding head comprises a coarse grinding section, a coarse and fine mixing switching surface and a fine grinding section which are arranged corresponding to the coarse grinding cavity, the coarse and fine mixing positioning table and the fine grinding cavity.
In order to make the grinding of the invention more sufficient, coarse grinding sand particles are arranged on the butt joint surfaces of the coarse grinding cavity and the coarse grinding section, coarse and fine mixed grinding sand particles are arranged on the butt joint surfaces of the coarse and fine mixing positioning table and the coarse and fine mixing switching surface, and fine grinding sand particles are arranged on the butt joint surfaces of the fine grinding cavity and the fine grinding section.
In order to conveniently select a more labor-saving operation mode according to the grinding force of the sample, a transverse handle is arranged on the upper end section of the rod body.
In order to conveniently select a more labor-saving operation mode according to the grinding force of the sample, a round handle is arranged at the top of the rod body.
In order to ensure high cooling speed, avoid the denaturation of the substances to be detected in the cells during the homogenization operation, and observe and control the homogenization degree at any time during the operation, the homogenization tube is made of shatter-resistant thickened glass material.
In order to make the grinding force direction of the invention more reasonable and sufficient, the coarse grinding cavity and the fine grinding cavity are both in a truncated cone shape with large upper part and small lower part.
In order to ensure high cooling speed, avoid the denaturation of the substances to be detected in the cells during the homogenization operation, and observe and control the homogenization degree at any time during the operation, the homogenization rod is formed by one-step molding of glass materials.
In order to make the invention more rigid and not easy to break, the homogenizing rod adopts a solid structure.
In order to facilitate centralized diversion of the homogenate in all directions, the homogenate adhered to the pipe wall is reduced to the maximum extent, the quantity required by experimental detection is ensured, and a plurality of everting diversion ports are arranged at the top opening of the anti-overflow cavity.
In order to facilitate the direct introduction of the buffer solution into the grinding area in the homogenizing process and reduce the loss of the viscous liquid on the wall of the homogenizing pipe, so as to accurately quantify the liquid, the rod body and the grinding head are provided with liquid introduction grooves penetrating through the splash-proof cover.
Compared with the prior art, the invention has the following advantages:
1. the grinding head is designed into a corresponding rough grinding section, a rough and fine mixing transfer surface and a fine grinding section, and animal and plant tissues and micro organisms can be respectively placed into corresponding areas for rough, fine or rough and fine mixing grinding according to the characteristics and experimental requirements of samples: firstly coarsely grinding a large amount of plant or animal tissues, and finely grinding after the sample is moderately treated; the method can be used for finely grinding tiny organisms or tiny tissues with very small quantity, samples subjected to zone grinding are more uniform, and experimental errors are reduced.
2. In the homogenizing process, the gravity center is concentrated at the bottom of the homogenizing pipe, so that the wall thickness of the bottom of the homogenizing pipe is designed to be larger than that of the side wall, and the homogenizing pipe can be prevented from being broken.
3. A splash-proof cover is designed between the rod body of the homogenizing rod and the grinding head, and liquid is prevented from splashing outside the homogenizing pipe wall and the pipe by utilizing the blocking effect of the splash-proof cover, so that the liquid and the sample are completely acted, and the integrity of the number of the samples is ensured.
4. The drum-shaped anti-overflow cavity is arranged above the rough grinding cavity, so that a small amount of liquid overflows from the side gap of the anti-overflow cover, and the liquid and the sample are completely acted by buffering in the anti-overflow cavity without splashing outside the homogenizing pipe by virtue of the drum-shaped design of the anti-overflow cavity.
The invention solves the limitation of the mortar and glass homogenizer on the size of the sample, can perform coarse grinding and coarse and fine mixing grinding on a large amount of animal and plant tissues under the required temperature condition according to the characteristics of the sample and the experimental requirement, and can perform fine grinding on a small amount of micro-organisms so as to enable various samples to achieve the effect of thorough homogenization quickly, thereby integrating ideal homogenization effect, high speed, wide adaptability, large capacity range, small sample loss, and multiple purposes of preventing buffer solution from splashing into a whole and being capable of keeping the activity of biological tissue samples.
Drawings
Fig. 1 is a schematic structural view of the present invention.
The labels shown in the figures and the corresponding component names are:
1. a homogenizing tube; 11. An anti-overflow cavity; 12. rough grinding the cavity; 13. finely grinding the cavity; 14. a coarse-fine mixing positioning table; 15. a diversion port;
2. a homogenizing rod; 21. a rod body; 22. a splash-proof cover; 23. a grinding head; 24. a liquid introduction groove; 25. a transverse handle; 26. a round handle; 231. rough grinding section; 232. a thick-thin mixing transfer surface; 233. and (5) finely grinding the sections.
Detailed Description
As can be seen from fig. 1, the multi-functional homogenizer of the present invention comprises a homogenizing tube 1 and a homogenizing rod inserted into the homogenizing tube 1, wherein,
the homogenizing pipe 1 is made of shatterproof thickened glass materials, the homogenizing pipe 1 comprises an overflow preventing cavity 11, a rough grinding cavity 12 and a fine grinding cavity 13 which are arranged in a way of being communicated with each other in a big-end-up way, the rough grinding cavity 12 and the fine grinding cavity 13 are both in a round table shape with big-end-up way, the axial length of the rough grinding cavity 12 is larger than that of the fine grinding cavity 13, a thick-thin mixing positioning table 14 is arranged between the rough grinding cavity 12 and the fine grinding cavity 13, two symmetrical outwards-turned diversion openings 15 are arranged at the top opening of the overflow preventing cavity 11, the overflow preventing cavity 11 is in a waist drum shape, the bottom of the fine grinding cavity 13 of the homogenizing pipe 1 is made of multiple layers of thick solid glass, and the wall thickness of the thin grinding cavity is larger than that of the side wall of the homogenizing pipe 1;
the homogenizing rod 2 is made of solid glass materials by one-step molding, the homogenizing rod 2 comprises a rod body 21, a splash-proof cover 22 and a grinding head 23 which are arranged up and down, the cross section area of the splash-proof cover 22 is smaller than the top opening of the spill-proof cavity 11 and larger than the largest outer diameter of the grinding head 23, the grinding head 23 comprises a rough grinding section 231, a rough and fine mixing transfer surface 232 and a fine grinding section 233 which are arranged corresponding to the rough grinding cavity 12, the rough and fine mixing positioning table 14 and the fine grinding cavity 13, rough grinding sand particles are arranged on the butt joint surface of the rough grinding section 231, fine grinding sand particles are arranged on the butt joint surface of the rough and fine mixing transfer surface 232, the middle part of the surface layer of the rod body 21 is downward until the lower end of the splash-proof cover 22 and the upper end of the rough grinding section 231 of the grinding head 23 are provided with liquid guide grooves 24 penetrating through the cover 22, the upper end section of the rough grinding section 231 is provided with a handle 25, and the handle 25 is labor-saving during sample grinding is rotated; a round handle 26 is arranged at the top of the rod body 21, and the transverse handle 25 and the round handle 26 can be simultaneously held when the sample is ground forcefully, so that the device is convenient and labor-saving, and the homogenization rate is improved;
the coarse and fine mixing positioning table 14 has the function of a clamping seat, when the homogenizing rod 2 is placed in the homogenizing pipe 1, the coarse grinding section 231 is just clamped at the upper part of the coarse and fine mixing positioning table 14 and is matched with the inner wall of the coarse grinding cavity 12 to form a coarse grinding area, the first coarse grinding of plant or animal tissues with a proper amount is realized, and after the sample grinding is moderate, the sample grinding is transferred to a fine grinding area at the lower part for fine grinding; the fine grinding section 233 is matched with the inner wall of the fine grinding cavity 13 to form a fine grinding area, so that a proper amount of tiny organisms or tiny tissues with very small quantity can be ground, and the coarsely ground sample can be finely ground again for later experiments; the gap of the rough grinding area is slightly larger than that of the fine grinding area, so that a large amount of animal and plant tissues can be conveniently rough ground; the fine grinding area is tightly divided, so that fine grinding of micro-organisms is facilitated, and samples in the coarse grinding area are difficult to fall and leak to the fine grinding area, so that a thorough homogenization effect is achieved quickly.
The application process of the invention is as follows:
1. before use, the washed homogenizing pipe 1 is separated from the homogenizing rod 2, is wrapped by tinfoil and is baked for 3 hours under the condition of 180 ℃ in an oven, and is cooled for reuse; or separately packaging with newspaper, placing in a sterilizing pan, sterilizing at 120deg.C for 25 min under high pressure, oven drying, and cooling.
2. When in use, the homogenizing tube 1 is obliquely placed in ice bath by the left hand, and the pretreated grinding sample to be measured such as plant and animal tissues is firstly placed in the rough grinding cavity 12 of the homogenizing tube 1, or the tiny organisms such as plant pathogenic nematodes, insect pathogenic nematodes, mites and the tiny tissues of the organisms in the dip-dyeing stage are directly placed in the fine grinding cavity 13 or at the bottom.
3. The pre-cooled homogenizing rod 2 is inserted into the homogenizing pipe 1 by the right hand, and as gaps among the grinding head 23 of the homogenizing rod 2, the rough grinding cavity 12, the rough and fine mixing positioning table 14 and the fine grinding cavity 13 of the homogenizing pipe 1 are small, the compatibility is good, and the rough and fine mixing positioning table 14 is completely matched with the rough and fine mixing switching surface 232.
4. The homogenizing pipe 1 is erected, and a small amount of pre-chilled buffer is added around the rough grinding section 231 along the liquid introducing groove 24, or the homogenizing rod 2 is lifted slightly upward, so that the buffer slowly flows around the fine grinding section 233.
5. The horizontal handle 25 is held by hand, or the horizontal handle 25 and the round handle 26 are held by hand simultaneously to grind tissues up and down, left and right for 10-40 times rapidly, and the number of times of homogenization depends on the experimental samples and purposes.
6. Pushing the preliminary sample coarsely ground around the coarse grinding section 231 into the fine grinding section 233, adding a small amount of pre-cooling buffer solution along the liquid introduction groove 24, flushing the remaining preliminary sample around the coarse grinding section 231 to the periphery of the fine grinding section 233, and performing rapid fine grinding again; in the rapid forced grinding process, because the clearance between the grinding matching area of the homogenizing rod 2 and the homogenizing pipe 1 is tight, the matching performance is good, a small amount of liquid can spill or splash occasionally, the splash-proof cover 22 can prevent the liquid from splashing outside the pipe wall and the pipe, and a small amount of liquid overflows from the side clearance of the splash-proof cover 22 can be buffered by virtue of the design of the spill-proof cavity 11 of the homogenizing pipe 1 and can not splash outside the homogenizing pipe at the bulge part of the waist drum shape, so that the liquid and the sample completely act, and the integrity of the number of the samples is ensured.
7. After finishing grinding, pouring the homogenate into a sterilized centrifuge tube along any one of the diversion ports 15 at the two ends of the wall of the homogenate tube 1, cleaning the homogenate tube 1 and the homogenate rod 2 by using the rest buffer solution, and pouring the cleaning solution into the homogenate for the next experiment. The whole homogenization process is operated at low temperature, the homogenization time is generally 6-8 minutes, and the homogenization time of skin and muscle tissues can be prolonged.
Claims (9)
1. A multifunctional homogenizer, comprising a homogenizing pipe (1) and a homogenizing rod (2) inserted in the homogenizing pipe, characterized in that: the utility model provides a thick fine grinding sand grain that thick slurry pipe bottom wall thickness is greater than the lateral wall thickness, the thick slurry pipe includes anti-overflow chamber (11), coarse grinding chamber (12) and fine grinding chamber (13) that big end down intercommunication was arranged be equipped with a thick fine mixing location platform (14) between coarse grinding chamber and the fine grinding chamber, the anti-overflow chamber is the waist drum shape, the thick slurry stick is including stick body (21), splashproof lid (22) and grinding head (23) that arrange from top to bottom, the cross-sectional area of splashproof lid is less than anti-overflow chamber open-ended and is greater than the grinding head external diameter, and this grinding head includes coarse grinding section (231), thick fine mixing changeover surface (232) and fine grinding section (233) that correspond to be arranged with coarse grinding chamber, thick fine mixing location platform and fine grinding chamber all are equipped with thick fine grinding sand grain on the butt joint face of thick fine mixing changeover surface coarse grinding chamber and fine grinding section all are equipped with thick fine grinding sand grain.
2. The multi-function homogenizer according to claim 1, wherein: a transverse handle (25) is arranged on the upper end section of the rod body.
3. The multi-function homogenizer according to claim 1, wherein: a round handle (26) is arranged at the top of the rod body.
4. A multi-function homogenizer according to any of claims 1 to 3, wherein: the homogenizing pipe is made of shatterproof thickened glass materials.
5. A multi-function homogenizer according to any of claims 1 to 3, wherein: the coarse grinding cavity and the fine grinding cavity are both in a truncated cone shape with large upper part and small lower part.
6. A multi-function homogenizer according to any of claims 1 to 3, wherein: the homogenizing rod is formed by one-step molding of glass materials.
7. A multi-function homogenizer according to any of claims 1 to 3, wherein: the homogenizing rod adopts a solid structure.
8. A multi-function homogenizer according to any of claims 1 to 3, wherein: a plurality of outwards turned guide flow ports (15) are arranged at the top opening of the anti-overflow cavity.
9. A multi-function homogenizer according to any of claims 1 to 3, wherein: the rod body and the grinding head are provided with a liquid introduction groove (24) penetrating through the splash-proof cover.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810076570.7A CN108362534B (en) | 2018-01-26 | 2018-01-26 | Multifunctional homogenizer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810076570.7A CN108362534B (en) | 2018-01-26 | 2018-01-26 | Multifunctional homogenizer |
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| CN108362534A CN108362534A (en) | 2018-08-03 |
| CN108362534B true CN108362534B (en) | 2023-11-03 |
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| USD984671S1 (en) | 2020-12-09 | 2023-04-25 | Studio 010 Inc. | Mortar and pestle |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| IE20030856A1 (en) * | 2003-11-14 | 2005-06-15 | Enfer Technology Ltd | Sample homogeniser |
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| CN203091036U (en) * | 2013-01-08 | 2013-07-31 | 上海海洋大学 | Rapid labor-saving tissue grinder |
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| CN106244437A (en) * | 2016-08-10 | 2016-12-21 | 安徽惠恩生物科技股份有限公司 | A kind of shearing histiocyte refiner |
| CN206509080U (en) * | 2017-01-17 | 2017-09-22 | 云南绿生中药科技股份有限公司 | A kind of Chinese herbal medicine super grinder |
| CN206613547U (en) * | 2017-02-24 | 2017-11-07 | 内蒙古医科大学 | Extract histocyte albumen refiner |
| CN207717464U (en) * | 2018-01-26 | 2018-08-10 | 中国农业科学院麻类研究所 | Biological homogenate device |
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| CN108362534A (en) | 2018-08-03 |
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