CN108355110B

CN108355110B - Traditional Chinese medicine composition for treating liver metastasis of pancreatic cancer and preparation method thereof

Info

Publication number: CN108355110B
Application number: CN201810377877.0A
Authority: CN
Inventors: 瞿存业; 戴竞耀
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-04-25
Filing date: 2018-04-25
Publication date: 2021-01-08
Anticipated expiration: 2038-04-25
Also published as: CN108355110A

Abstract

The invention provides a traditional Chinese medicine composition for treating pancreatic cancer liver metastasis and a preparation method thereof, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 30-35 parts of astragalus membranaceus, 5-10 parts of cortex moutan, 10-15 parts of golden cypress, 15-18 parts of radix bupleuri, 10-15 parts of scutellaria baicalensis, 10-15 parts of pinellia ternate, 12-16 parts of immature bitter orange, 12-16 parts of red paeony root, 25-35 parts of raw liquorice, 25-35 parts of mangnolia officinalis, 30-35 parts of rhizoma corydalis, 25-35 parts of sargentgloryvine stem, 10-15 parts of rhizoma sparganii, 10-15 parts of curcuma zedoary, 15-18 parts of panax notoginseng, 10-15 parts of turtle shell, 20-25 parts of angelica sinensis, 18-20 parts of fructus corni, 30-40 parts of raw oyster, 10-15 parts of rhizoma polygonati officinalis, 30-35 parts of polygonum cuspidatum, 10-15 parts of sculellaria barba. The invention has the advantages of scientific compatibility of all components, enhanced targeting effect, full play of treatment efficacy, simple preparation method, easily obtained raw materials, safety, reliability, no toxic or side effect and wide clinical application prospect.

Description

Traditional Chinese medicine composition for treating liver metastasis of pancreatic cancer and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating pancreatic cancer liver metastasis and a preparation method thereof.

Background

Pancreatic cancer is one of common digestive tract malignant tumors, has hidden onset, high malignancy degree and strong invasiveness, so that diagnosis and treatment are extremely difficult. The morbidity and mortality of the cancer patients are obviously increased in recent years, the 5-year survival rate is only 1% -3%, the cancer patients are the fourth and the worst malignant tumors.

The pancreas is rich in blood supply, lacks a complete capsule and is easy to diffuse and transfer. Particularly, in the advanced stage of pancreatic cancer, when hematogenous metastasis occurs, the liver is the most common affected organ, so that the prognosis is worse and the treatment becomes more troublesome.

The symptoms of the metastasis of the pancreatic cancer and the liver are distending pain in the right hypochondrium, chest distress and gastric stuffiness, abdominal distension and anorexia, or irritability and irritability, distending pain in the chest and back, red tongue with yellow and greasy coating and wiry and smooth pulse. Stagnation of liver qi, retention of damp-heat in the interior, distending pain in the right hypochondrium, chest distress, gastric stuffiness, and qi stagnation failing to move, resulting in abdominal distension and anorexia. The liver and gallbladder fire stagnation can cause restlessness and irritability. The liver-qi is uncomfortable and the gallbladder fire is flaming upward, so the chest and the back are distending and pain. The tongue is red with yellow and greasy coating and the pulse is wiry and slippery due to the excessive damp-heat in the interior.

Surgery or radio frequency therapy is often the recommended curative treatment for patients with liver metastases of pancreatic cancer alone. Both of them have limitations in that they do not contribute to liver metastasis which is frequently occurring, has a large tumor burden and has technical difficulties in the region, and cannot effectively prevent recurrence. In addition, systemic chemotherapy is also a common standard treatment method for liver metastasis in advanced pancreatic cancer, but the toxic and side effects of chemotherapeutic drugs seriously affect the immune system, and the pancreatic cancer often has poor responsiveness to chemotherapy. Therefore, the treatment of liver metastasis of pancreatic cancer is very difficult.

Disclosure of Invention

Aiming at the defects and problems in the prior art, the embodiment of the invention aims to provide the traditional Chinese medicine composition for treating the liver metastasis of the pancreatic cancer and the preparation method thereof, and the traditional Chinese medicine composition has the advantages of obvious curative effect, safety, reliability, no toxic or side effect and wide clinical application prospect.

In order to achieve the purpose, the invention provides the following technical scheme:

the traditional Chinese medicine composition for treating liver metastasis of pancreatic cancer is prepared from the following raw materials in parts by weight: 30-35 parts of astragalus membranaceus, 5-10 parts of cortex moutan, 10-15 parts of golden cypress, 15-18 parts of radix bupleuri, 10-15 parts of scutellaria baicalensis, 10-15 parts of pinellia ternate, 12-16 parts of immature bitter orange, 12-16 parts of red paeony root, 25-35 parts of raw liquorice, 25-35 parts of mangnolia officinalis, 30-35 parts of rhizoma corydalis, 25-35 parts of sargentgloryvine stem, 10-15 parts of rhizoma sparganii, 10-15 parts of curcuma zedoary, 15-18 parts of panax notoginseng, 10-15 parts of turtle shell, 20-25 parts of angelica sinensis, 18-20 parts of fructus corni, 30-40 parts of raw oyster, 10-15 parts of rhizoma polygonati officinalis, 30-35 parts of polygonum cuspidatum, 10-15 parts of sculellaria barba.

Further, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 35 parts of astragalus membranaceus, 10 parts of cortex moutan, 10 parts of golden cypress, 18 parts of radix bupleuri, 15 parts of scutellaria baicalensis, 10 parts of pinellia ternate, 12 parts of immature bitter orange, 15 parts of radix paeoniae rubra, 28 parts of raw liquorice, 30 parts of mangnolia officinalis, 35 parts of rhizoma corydalis, 30 parts of sargentgloryvine stem, 15 parts of rhizoma sparganii, 12 parts of curcuma zedoary, 18 parts of panax notoginseng, 10 parts of turtle shell, 22 parts of angelica sinensis, 20 parts of cornus officinalis, 35 parts of raw oyster, 12 parts of rhizoma polygonati officinalis, 35 parts of polygonum cuspidatum, 12 parts of sculel.

Further, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 parts of astragalus membranaceus, 9 parts of cortex moutan, 12 parts of golden cypress, 15 parts of radix bupleuri, 12 parts of scutellaria baicalensis, 12 parts of pinellia ternate, 15 parts of immature bitter orange, 15 parts of radix paeoniae rubra, 30 parts of raw liquorice, 30 parts of mangnolia officinalis, 30 parts of rhizoma corydalis, 30 parts of sargentgloryvine stem, 12 parts of rhizoma sparganii, 12 parts of curcuma zedoary, 15 parts of panax notoginseng, 12 parts of turtle shell, 20 parts of angelica sinensis, 20 parts of cornus officinalis, 30 parts of raw oyster, 12 parts of rhizoma polygonati officinalis, 30 parts of polygonum cuspidatum, 12 parts of sculel.

Further, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 parts of astragalus membranaceus, 6 parts of cortex moutan, 15 parts of golden cypress, 16 parts of radix bupleuri, 15 parts of scutellaria baicalensis, 15 parts of pinellia ternate, 15 parts of immature bitter orange, 16 parts of radix paeoniae rubra, 35 parts of raw liquorice, 28 parts of mangnolia officinalis, 33 parts of rhizoma corydalis, 35 parts of sargentgloryvine stem, 15 parts of rhizoma sparganii, 15 parts of curcuma zedoary, 18 parts of panax notoginseng, 15 parts of turtle shell, 25 parts of angelica sinensis, 18 parts of cornus officinalis, 40 parts of raw oyster, 10 parts of rhizoma polygonati officinalis, 30 parts of polygonum cuspidatum, 15 parts of scu.

A preparation method of a traditional Chinese medicine composition for treating liver metastasis of pancreatic cancer comprises the following steps:

step one, mixing the raw materials according to the formula amount, adding water to soak the medicine powder, and soaking for 40-50 minutes;

step two, continuously adding water into the raw materials soaked in the step one until the water level is 2-3 cm, decocting the raw materials with strong fire until the raw materials are boiled, continuously decocting the raw materials with slow fire for 40-50 minutes, and filtering the decoction to obtain filtrate for later use;

and step three, continuously adding water into the filter residue obtained in the step two until the water level is 2-3 cm, decocting with strong fire until the water level is boiling, decocting with slow fire for 40-50 minutes, filtering, taking the filtrate, and mixing with the filtrate obtained in the step two.

The medicine of the invention has reasonable compatibility, and the action principle is as follows:

astragalus root: sweet in nature and slightly warm. It enters spleen and lung meridians. Has the effects of invigorating qi, invigorating yang, protecting health, promoting pus discharge, promoting granulation, inducing diuresis, and relieving swelling, and is mainly prepared from radix astragali polysaccharide, saponins, flavonoids, amino acids, etc.

The invention utilizes the astragalus polysaccharide and flavonoid components in astragalus to play roles of protecting liver, relaxing vascular smooth muscle, lifting yang qi and tonifying liver and spleen yang qi deficiency for pancreatic cancer patients.

Cortex moutan: is bitter, pungent and slightly cold in taste, enters heart, liver and kidney meridians, and has the effects of clearing heat and cooling blood, and activating blood circulation to dissipate blood stasis. The paeonol and other glycoside components contained in the composition have antiinflammatory and platelet inhibiting effects on liver metastasis of pancreatic cancer.

Phellodendron bark: sweet and cold in flavor, entering kidney, bladder and large intestine meridians, and has the functions of clearing heat and drying dampness, purging fire and removing toxicity and reducing deficiency heat.

The invention utilizes berberine, jateorhizine, magnoflorine, phellodendrine, tetrandrine and other alkaloids contained in phellodendron bark to play the roles of resisting inflammation, relieving fever, reducing interferon and inhibiting cancer cell replication on pancreatic cancer liver metastasis.

Bupleurum root: bitter, pungent and slightly cold in flavor, entering heart envelope, liver, triple energizer and gallbladder channel, and has the functions of relieving fever, soothing liver, resolving depression and lifting yang qi.

The invention utilizes the saikosaponin, rutin, quercetin and polysaccharide components contained in bupleurum to promote the generation of tumor necrosis factor for the liver metastasis of pancreatic cancer, thereby achieving the effect of resisting cancer.

Scutellaria baicalensis: is bitter in taste and cold in nature, and has the effects of clearing heat and drying dampness, purging fire and removing toxicity, and stopping bleeding and preventing miscarriage.

The invention utilizes baicalin, wogonin, baicalein, wogonin and the like contained in the scutellaria baicalensis to play roles of resisting inflammation, oxidation, tumor and immunoregulation on the liver metastasis of pancreatic cancer.

Pinellia ternata: pungent and warm in flavor, enter spleen, stomach and lung meridians, and have the effects of eliminating dampness and phlegm, lowering adverse qi and relieving vomit, and relieving distension and fullness and dispersing accumulation of pathogen.

The invention utilizes alkaloid, sitosterol and guanosine contained in the pinellia ternata to play roles of dissolving phlegm and dissipating stagnation.

Red peony root: bitter in taste and slightly cold in nature, enters liver meridian, and has the effects of clearing heat, cooling blood, removing blood stasis and relieving pain.

The invention utilizes paeoniflorin, albiflorin, oxypaeoniflorin, paeoniflorin and paeoniflorin contained in the red paeony root to play roles of anticoagulation, antithrombotic and platelet aggregation inhibition on pancreatic cancer liver metastasis.

Three-edge: bitter in taste and mild in nature, enters liver and spleen meridians, and has the effects of breaking blood, removing blood stasis, promoting qi circulation and relieving pain.

The invention utilizes the flavonoid and saponin components contained in the rhizoma sparganii to play roles in resisting platelet aggregation, resisting thrombus and reducing blood viscosity on the liver metastasis of pancreatic cancer.

Pseudo-ginseng: sweet in taste, slightly bitter and warm in nature, enters liver and stomach meridians, and has the effects of removing blood stasis, stopping bleeding, promoting blood circulation and relieving pain.

The invention utilizes notoginsenoside, ginsenoside, notoginseng polysaccharide and notoginseng flavone contained in notoginseng to play roles of activating blood, reducing vascular fragility and improving vascular permeability on pancreatic cancer liver metastasis.

Raw oyster shells: salty taste and slight cold, enter liver and kidney meridians, and have the effects of calming liver, suppressing yang hyperactivity, softening hardness, dissipating stagnation, astringing and inducing astringency.

The present invention utilizes dansyl amino acid contained in oyster to reduce transaminase, reduce peroxide, resist oxidation and inhibit tumor cell growth.

Giant knotweed rhizome: is bitter and cold in taste, enters liver, gallbladder and lung channels, and has the effects of promoting blood circulation, relieving pain, clearing heat, promoting diuresis, removing toxic substances, eliminating phlegm and relieving cough.

The invention utilizes the anthraquinone, stilbene, flavonoid and coumarin components contained in the giant knotweed to play the roles of resisting inflammation, resisting thrombus, changing blood rheology, expanding blood vessels and resisting tumors on pancreatic cancer liver metastasis.

Herba Hedyotidis Diffusae: slightly bitter in taste, sweet and cold. Entering stomach, large intestine and small intestine channels, has effects of clearing heat, promoting diuresis, removing toxic substance and resolving carbuncle.

The invention utilizes the components of flavonoid, triterpenes, anthraquinones, iridoid glycoside terpenoids, polysaccharides and the like contained in the oldenlandia diffusa to play a plurality of pharmacological activities of resisting inflammation, resisting tumors, reducing blood fat, reducing blood sugar and the like on patients with pancreatic cancer liver metastasis.

The radix bupleuri, the immature bitter orange, the red paeony root and the liquorice in the above components form the typhoid famous prescription Sirensan which is a monarch drug. Liver qi stagnation means that yang qi does not reach four limbs, so it is the four adverse qi. Qi moving causes blood to move, and qi stagnation causes blood stasis. Liver stagnation, blood stasis leading to endogenous qi, and deficiency of healthy qi, which are the cause of cancer and tumor. The Siyisan licorice root, radix glycyrrhizae, radix bupleuri, radix paeoniae rubra, radix bupleuri, radix paeoniae rubra, radix glycyrrhizae, qi-tonifying and spleen-strengthening powder. Therefore, the four herbs are used in heavy dose to achieve the purpose of eliminating pathogenic factors and regulating qi and blood. The four ingredients are the essential drugs for the prescription.

Yang stagnation failing to extend and leading to internal heat. Because there is always yang-nourishing property below hardness, Bai Qin, Dan Pi and Huang Bai are used as ministerial drugs to clear qi and blood and stagnate heat. Tumors accumulate and tend to produce internal heat, manifesting as low grade fever, elevated transaminase and elevated inflammatory factors, such as interleukin 2, 6, etc. The three auxiliary drugs strengthen the efficacy of the monarch drug, supplement each other and synergize.

Rhizoma corydalis, sargentgloryvine stem, common burreed rhizome, zedoary, pseudo-ginseng, Chinese angelica and giant knotweed rhizome are used together to strengthen the functions of dissolving stasis and breaking knots and eliminating cancer and swelling, and are used as adjuvant drugs. Dang Gui, shan Yu Rou, Bie Jia and mu Li, which are used as adjuvant drugs, can nourish liver and pacify liver.

Scutellaria barbata and Oldenlandia diffusa contain anticancer components and have the functions of clearing heat and removing toxicity, and are used as guiding drugs, namely the drugs can be selected.

The invention has convenient material taking, all the used medicines are conventional medicines, and the preparation method is only a conventional preparation method without special treatment. Has mild effect, no toxic and side effects, and no drug with severe toxicity.

According to the medicine idea of the invention, the progress of the liver metastasis disease course of the pancreatic cancer can be effectively controlled, and the life cycle of a patient is effectively prolonged. During the administration period, the medicine can take effect after two treatment courses (20 days).

Compared with the prior art, the traditional Chinese medicine composition for treating pancreatic cancer liver metastasis and the preparation method thereof provided by the invention have the beneficial effects that:

1. the traditional Chinese medicine composition is scientific in compatibility, enhances the targeting effect, has low cost compared with the high cost of surgery, chemotherapy and target drugs, and can effectively reduce the burden of patients and the social cost.

2. The traditional Chinese medicine composition has quick response. In the treatment process of the medicine, the patient takes effect quickly, and the symptoms are relieved quickly. Metastatic size changes were observed by CT within 20 days after dosing.

3. Compared with operation wound, the medicine has no wound and needs no long-term recovery. In addition, the medicine has no side effect caused by chemotherapy, is safe and reliable, has no toxic or side effect, and can quickly recover the body of a patient.

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

The traditional Chinese medicine composition for treating liver metastasis of pancreatic cancer is prepared from the following raw materials in parts by weight: 35 parts of astragalus membranaceus, 10 parts of cortex moutan, 10 parts of golden cypress, 18 parts of radix bupleuri, 15 parts of scutellaria baicalensis, 10 parts of pinellia ternate, 12 parts of immature bitter orange, 15 parts of radix paeoniae rubra, 28 parts of raw liquorice, 30 parts of mangnolia officinalis, 35 parts of rhizoma corydalis, 30 parts of sargentgloryvine stem, 15 parts of rhizoma sparganii, 12 parts of curcuma zedoary, 18 parts of panax notoginseng, 10 parts of turtle shell, 22 parts of angelica sinensis, 20 parts of cornus officinalis, 35 parts of raw oyster, 12 parts of rhizoma polygonati officinalis, 35 parts of polygonum cuspidatum, 12 parts of sculel.

Example 2

The traditional Chinese medicine composition for treating liver metastasis of pancreatic cancer is prepared from the following raw materials in parts by weight: 30 parts of astragalus membranaceus, 9 parts of cortex moutan, 12 parts of golden cypress, 15 parts of radix bupleuri, 12 parts of scutellaria baicalensis, 12 parts of pinellia ternate, 15 parts of immature bitter orange, 15 parts of radix paeoniae rubra, 30 parts of raw liquorice, 30 parts of mangnolia officinalis, 30 parts of rhizoma corydalis, 30 parts of sargentgloryvine stem, 12 parts of rhizoma sparganii, 12 parts of curcuma zedoary, 15 parts of panax notoginseng, 12 parts of turtle shell, 20 parts of angelica sinensis, 20 parts of cornus officinalis, 30 parts of raw oyster, 12 parts of rhizoma polygonati officinalis, 30 parts of polygonum cuspidatum, 12 parts of sculel.

Example 3

The traditional Chinese medicine composition for treating liver metastasis of pancreatic cancer is prepared from the following raw materials in parts by weight: 30 parts of astragalus membranaceus, 6 parts of cortex moutan, 15 parts of golden cypress, 16 parts of radix bupleuri, 15 parts of scutellaria baicalensis, 15 parts of pinellia ternate, 15 parts of immature bitter orange, 16 parts of radix paeoniae rubra, 35 parts of raw liquorice, 28 parts of mangnolia officinalis, 33 parts of rhizoma corydalis, 35 parts of sargentgloryvine stem, 15 parts of rhizoma sparganii, 15 parts of curcuma zedoary, 18 parts of panax notoginseng, 15 parts of turtle shell, 25 parts of angelica sinensis, 18 parts of cornus officinalis, 40 parts of raw oyster, 10 parts of rhizoma polygonati officinalis, 30 parts of polygonum cuspidatum, 15 parts of scu.

Example 4

This embodiment provides a method for preparing the Chinese medicinal composition for treating liver metastasis of pancreatic cancer according to embodiments 1 to 3, which comprises the following steps:

step one, mixing the raw materials according to the formula amount, adding water to soak the powder, and soaking for 40 minutes;

step two, continuously adding water into the raw materials soaked in the step one until the water level is 2-3 cm, decocting the raw materials with strong fire until the raw materials are boiled, continuously decocting the raw materials with slow fire for 40 minutes, and filtering the decoction to obtain filtrate for later use;

and step three, continuously adding water into the filter residue obtained in the step two until the water level is 2-3 cm, decocting the mixture with strong fire until the mixture is boiled, decocting the mixture with slow fire for 40 minutes, filtering the mixture, taking the filtrate, and mixing the filtrate with the filtrate obtained in the step two.

Clinical cases:

30 clinical pancreatic cancer patients were selected and randomized into 2 groups of 15 individuals, including control and test groups. The 15 patients in the control group were treated with conventional chemotherapy; 15 patients in the test group were treated with the Chinese medicinal composition for treating liver metastasis of pancreatic cancer of this example 1. Firstly, respectively detecting and collecting pancreatic cancer indexes CA199 and tumor sizes in the blood serum of two groups of patients, and after continuously treating the two groups of patients for 15 days by adopting different treatment modes respectively, detecting and recording the pancreatic cancer indexes CA199 and the tumor sizes in the blood serum of each patient; after 45 days of continued treatment, the pancreatic cancer index CA199 and tumor size in the serum of each patient was again examined and statistically analyzed, with the results shown in table 1:

TABLE 1 pancreatic cancer treatment test results

As can be seen from the test results in Table 1, the mean index of pancreatic cancer CA199 and the tumor size in the serum of the patients in the test group are significantly reduced after 15d and 45d of treatment, and the reduction is significantly higher than that of the mean index of pancreatic cancer CA199 and the tumor size in the serum of the patients in the control group. Therefore, the treatment effect of the traditional Chinese medicine composition for treating the liver metastasis of the pancreatic cancer is obviously better than that of the conventional chemotherapy, and the traditional Chinese medicine composition is safe and reliable and has no toxic or side effect on the body of a patient.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. A traditional Chinese medicine composition for treating liver metastasis of pancreatic cancer is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30-35 parts of astragalus membranaceus, 5-10 parts of cortex moutan, 10-15 parts of golden cypress, 15-18 parts of radix bupleuri, 10-15 parts of scutellaria baicalensis, 10-15 parts of pinellia ternate, 12-16 parts of immature bitter orange, 12-16 parts of red paeony root, 25-35 parts of raw liquorice, 25-35 parts of mangnolia officinalis, 30-35 parts of rhizoma corydalis, 25-35 parts of sargentgloryvine stem, 10-15 parts of rhizoma sparganii, 10-15 parts of curcuma zedoary, 15-18 parts of panax notoginseng, 10-15 parts of turtle shell, 20-25 parts of angelica sinensis, 18-20 parts of fructus corni, 30-40 parts of raw oyster, 10-15 parts of cornus officinalis, 30-35 parts of polygonum cuspidatum, 10-15 parts of sculellaria barbata;

the preparation method of the traditional Chinese medicine composition for treating pancreatic cancer liver metastasis comprises the following steps:

2. The traditional Chinese medicine composition for treating liver metastasis of pancreatic cancer according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 35 parts of astragalus membranaceus, 10 parts of cortex moutan, 10 parts of golden cypress, 18 parts of radix bupleuri, 15 parts of scutellaria baicalensis, 10 parts of pinellia ternate, 12 parts of immature bitter orange, 15 parts of radix paeoniae rubra, 28 parts of raw liquorice, 30 parts of mangnolia officinalis, 35 parts of rhizoma corydalis, 30 parts of sargentgloryvine stem, 15 parts of rhizoma sparganii, 12 parts of curcuma zedoary, 18 parts of panax notoginseng, 10 parts of turtle shell, 22 parts of angelica sinensis, 20 parts of cornus officinalis, 35 parts of raw oyster, 12 parts of rhizoma polygonati officinalis, 35 parts of polygonum cuspidatum, 12 parts of sculel.

3. The traditional Chinese medicine composition for treating liver metastasis of pancreatic cancer according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 parts of astragalus membranaceus, 9 parts of cortex moutan, 12 parts of golden cypress, 15 parts of radix bupleuri, 12 parts of scutellaria baicalensis, 12 parts of pinellia ternate, 15 parts of immature bitter orange, 15 parts of radix paeoniae rubra, 30 parts of raw liquorice, 30 parts of mangnolia officinalis, 30 parts of rhizoma corydalis, 30 parts of sargentgloryvine stem, 12 parts of rhizoma sparganii, 12 parts of curcuma zedoary, 15 parts of panax notoginseng, 12 parts of turtle shell, 20 parts of angelica sinensis, 20 parts of cornus officinalis, 30 parts of raw oyster, 12 parts of rhizoma polygonati officinalis, 30 parts of polygonum cuspidatum, 12 parts of sculel.

4. The traditional Chinese medicine composition for treating liver metastasis of pancreatic cancer according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 parts of astragalus membranaceus, 6 parts of cortex moutan, 15 parts of golden cypress, 16 parts of radix bupleuri, 15 parts of scutellaria baicalensis, 15 parts of pinellia ternate, 15 parts of immature bitter orange, 16 parts of radix paeoniae rubra, 35 parts of raw liquorice, 28 parts of mangnolia officinalis, 33 parts of rhizoma corydalis, 35 parts of sargentgloryvine stem, 15 parts of rhizoma sparganii, 15 parts of curcuma zedoary, 18 parts of panax notoginseng, 15 parts of turtle shell, 25 parts of angelica sinensis, 18 parts of cornus officinalis, 40 parts of raw oyster, 10 parts of rhizoma polygonati officinalis, 30 parts of polygonum cuspidatum, 15 parts of scu.