CN108353908A - A kind of agriculture bactericidal composition containing ether azoles sulfanilamide (SN) ester type compound and cyazofamid - Google Patents
A kind of agriculture bactericidal composition containing ether azoles sulfanilamide (SN) ester type compound and cyazofamid Download PDFInfo
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- CN108353908A CN108353908A CN201810203924.XA CN201810203924A CN108353908A CN 108353908 A CN108353908 A CN 108353908A CN 201810203924 A CN201810203924 A CN 201810203924A CN 108353908 A CN108353908 A CN 108353908A
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- cyazofamid
- bactericidal composition
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- 0 C*(C)[n](cn1)nc1S(O/C1=C/C/C=C/C/C=C1)(=O)=O Chemical compound C*(C)[n](cn1)nc1S(O/C1=C/C/C=C/C/C=C1)(=O)=O 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention provides a kind of agriculture bactericidal composition, and the composition is by the compound with chemical constitution formula (I) with cyazofamid according to weight ratio 50:1~1:50 compositions.The present invention also provides the fungicide containing the agriculture bactericidal composition and its in the application of prevention cucumber downy mildew, tomato late blight and early blight of tomato.The combination has significant synergistic effect to disease, can effectively reduce times for spraying, reduce drug cost, reduces pollution and the pesticide residue to environment, action site increases, and is conducive to overcome and delay the generation of the drug resistance of germ.The present composition is without obvious harmful effects to trial crops, and leaf color, growing way etc. are all normal, and safety is good, meets the security requirement of pesticidal preparations.
Description
【Technical field】
The invention belongs to technical field of pesticide.More particularly it relates to which a kind of containing ether azoles sulfanilamide (SN) ester type compound
With the agriculture bactericidal composition of cyazofamid, the purposes of the agriculture bactericidal composition is further related to.
【Background technology】
Chinese patent application CN 201610003201.6, denomination of invention " a kind of Fungicidal compounds, microbicide compositions and
Preparation and its application " discloses a kind of compound with bactericidal activity, using the compound as the fungicide group of active constituent
It closes object and preparation and its application, compound (the being referred to as compound Y14079) structure is as follows：
The Fungicidal compounds and preparation containing the Fungicidal compounds imitate cucumber downy mildew and rice sheath blight disease controlling
Fruit is notable.
The chloro- 2- cyano -5- p-methylphenyls of cyazofamid (Cyazofamid) chemical name 4--imidazoles -1-N, N- dimethyl
Sulfonamide belongs to imidazoles series bactericidal agent.The medical instrument has certain interior suction and therapeutic activity, lasting period length, resistance of rainwater washing against, to ovum
Downy mildew caused by Gammaproteobacteria, epidemic disease etc. have good control effect, and the pathogen for generating resistance or sensitivity to metalaxyl has
Activity.Its mechanism of action is：The synthesis that cell ATP is prevented by inhibiting the electron transmission between cytochrome b and c1, to
Inhibit the respiration of disease fungus.
But a kind of medicament is used alone for a long time, it is easy that pathogen is made to develop immunity to drugs, causes being decreased obviously for drug effect, from
And dosage is caused to rise significantly, cycle time is sprayed, and using effect is poor, increases cost, the increasing of dosage makes
The resistance of pathogen is more serious, while can be impacted to environment.Rational chemical bactericide combination or mixture, which has, to be expanded
Fungicidal spectrum improves the positive features such as control effect, the generation for delaying drug resistance of fungi and development.Therefore, research is opened
Efficient, less toxic, environmental protection the bactericidal composition of hair and fungicide have positive effect to agricultural sustainable development.
【Invention content】
The purpose of the present invention is overcoming single drug defect, a kind of agriculture bactericidal composition is provided and contains the combination
The agricultural bacteriocide of object, and the purposes of the agricultural bactericidal composition or fungicide is provided.
To achieve the goals above, the present invention provides a kind of agriculture bactericidal composition, and the composition is by with following chemistry
The compound of structure formula (I) is with cyazofamid according to weight ratio 50:1~1:50 compositions：
Preferably, chemical constitution formula (I) compound and the weight ratio of cyazofamid are 10:1~1:10.
The present invention also provides a kind of agricultural bacteriocide, which contains 0.5~95.0% above-mentioned agricultural by weight and kills
Bacteria composition and surplus are agriculturally acceptable carrier and auxiliary agent.
Preferably, it is agriculturally which, which contains 10~60% above-mentioned agriculture bactericidal composition and surplus by weight,
Acceptable carrier and auxiliary agent.
In the present invention, the dosage form of the disinfectant use in agriculture is water dispersion granule, wettable powder, suspending agent, does and hang
Floating agent, missible oil, aqueous emulsion or microemulsion.
The present invention also provides above-mentioned agriculture bactericidal compositions or agricultural bacteriocide in prevention cucumber downy mildew, tomato late blight
And/or the purposes in early blight of tomato.
Further, the present invention also provides a kind of methods of prevention crop disease, in crops and/or fruit introduced disease
Before or after, apply above-mentioned bactericidal composition or fungicide to the place of crops and/or fruit and growth or storage.
The present invention is described in more detail below.
The present invention relates to a kind of agriculture bactericidal compositions.The agriculture bactericidal composition is by with following chemical structural formulas
(I) compound is with cyazofamid according to weight ratio 50:1~1:50 compositions：
The compound be Chinese invention patent application CN 201610003201.6, denomination of invention " a kind of Fungicidal compounds,
(the also referred to as compound Y14079 of formula (II) compound disclosed in microbicide compositions and preparation and its application ".In the present invention
In to simplify the description, with active constituent Y14079 represent).It is described according to patent application CN 201610003201.6
Prepared by synthetic route (2).
In agriculture bactericidal composition of the invention, when the amount of active ingredient Y14079 is in the range, if cyanogen is white
The amount of azoles is more than the range of the amount, then can decline because of dosage height, safety, poisoning easily occurs.Similarly, the amount of cyazofamid is in institute
When in the range of stating, if the amount of active ingredient Y14079 is more than the range of the amount, it can also decline because of dosage height, safety,
Poisoning easily occurs.
Therefore, in agriculture bactericidal composition of the invention, the weight ratio of active ingredient Y14079 and cyazofamid is 50:1~
1:50 are reasonable.
Preferably, the weight ratio of active ingredient Y14079 and cyazofamid is 10:1~1:10.
The present invention relates to a kind of agricultural bacteriocides.The agricultural bacteriocide contains by weight described in 0.5~95.0%
Agriculture bactericidal composition and surplus be agriculturally acceptable carrier and auxiliary agent.
In the present invention, the carrier or auxiliary agent are it should be understood that for improving medicine in Pesticide formulation or use
Agent physicochemical property, improve drug effect, be readily transported storage etc. performances auxiliary substances, such as wetting agent, emulsifier, dispersant,
Sticker, stabilizer or synergist etc..It is every that there are these performances and agricultural bacteriocide of the present invention is not appointed according to the present invention
The chemical substance of what negative effect may be used to the present invention, they are all within protection scope of the present invention.
It can be because having if the agriculture bactericidal composition content of the agricultural bacteriocide is less than 0.5% according to the present invention
Effect ingredient is low, is unfavorable for the manufacturing of product from economic angle；If the agriculture bactericidal composition of the agricultural bacteriocide
When content is higher than 95.0%, then because of the too high performance for being unfavorable for drug effect of content and poisoning can be also easy to produce；Therefore, the agricultural sterilization
It is appropriate that the agriculture bactericidal composition content of agent, which is 0.5~95.0%,.
Preferably, the agricultural bacteriocide contains the agriculture bactericidal composition and surplus described in 15~60% by weight
For agriculturally acceptable carrier and auxiliary agent.
In the present invention, the carrier used is solid carrier or liquid-carrier.
The solid carrier is selected from silicate, carbonate, sulfate, oxide, alkali metal salt, vegetalitas carrier or conjunction
At earthfill rockfill concrete riprap RCC carrier etc..
Wherein silicate, carbonate, sulfate and oxide carrier are mineral substance carrier.
For example, silicate carrier is kaolin, sepiolite, nacrite, montmorillonite, mica, vermiculite, pyrophyllite or talcum
Deng.
Carbonate support is calcium carbonate or dolomite etc..
Sulfate carrier is ammonium sulfate, sodium sulphate or calcium sulfate etc..
Oxide carrier is quick lime, magnesium lime or diatomite etc..
Alkali metal salt carrier is potassium chloride or sodium chloride etc..
Vegetalitas carrier is citrus pulp, corncob cellulose, rice husk powder, rice husk, big soya bean stem meal, tobacco powder, walnut shell or sawmilling
Powder etc..
Synthetic filling class carrier is winnofil hydrate, winnofil or white carbon etc..
These solid carriers that the present invention uses are sold known to technical staff, currently on the market in the art
The by-product of the product or widely known agricultural byproducts processing sold.
The liquid-carrier (solvent) is selected from water, aromatic hydrocarbons, chlorinated aliphatic hydrocarbon, aliphatic hydrocarbon, alcohols, ethers, ketone, plant
Oil, methylated vegetable oils or other special solvents.
For example, aromatic hydrocarbons carrier is benzene, dimethylbenzene, toluene, alkylbenzene, alkylnaphthalene and chlorinated aromatic hydrocarbons etc..
Chlorinated aliphatic hydrocarbon carrier is vinyl chloride, chloroform, dichloromethane, chloroform, carbon tetrachloride and more chloroethanes etc..
Aliphatic hydrocarbon carrier is petroleum distillate, hexamethylene, light mineral oil or paraffin etc., such as limited by Jiangsu China human relations chemical industry
The S-200 fat hydrocarbon products of company's sale being mainly made of octane and heptane.
Alcoholic vehicle is methanol, ethyl alcohol, isopropanol, butanol, isobutanol, ethylene glycol, propylene glycol, glycerine or fatty alcohol
Deng.
Ethers carrier is Propylene Glycol ether, ethohexadiol ether or petroleum ether etc..
Ketone is acetone, methyl ethyl ketone, methyl iso-butyl ketone (MIBK), cyclohexanone, isophorone or N- methyl-pyrrolidons etc..
In the present invention, the special solvent is it should be understood that the solvent being used in mixed way with one or more of solvents.It is described
Solvent in special solvent is dimethylformamide, dimethyl sulfoxide (DMSO), polyethylene glycol or nitrile etc..
Vegetable oil is soybean oil, rapeseed oil, peanut oil or sesame oil etc..
Methylated vegetable oils are methylated soya oil, rapeseed oil, peanut oil or sesame oil etc..What the present invention used methylates
Vegetable oil is all in current market sales of product.
The liquid-carrier that the present invention uses all is in the art known to technical staff, current market sales of
Product, for example, sold by Sinopec Group Hangzhou Refinery light mineral oil, by Shanghai Sheng Jun Industry investments Co., Ltd
Propylene Glycol ether, ethohexadiol ether, methyl iso-butyl ketone (MIBK), isophorone, the dimethylformamide of sale.
When using a kind of above-mentioned organic solvent when, this organic solvent can with single use, can also from it is other different
Organic solvent is used in mixed way, or is used in mixed way with water.When used as a mixture, mixed proportion can according to actual use situation into
Row selection, this is that hell and high water is not present for those skilled in the art.
The auxiliary agent that the present invention uses selected from emulsifier, dispersant, stabilizer or wetting agent surfactant, disappear
Infusion, thickener, suspending agent and antifreezing agent.
The surfactant is the surfactant used in emulsifier, dispersant, stabilizer or wetting agent.
The surfactant that the present invention uses can be ionic or nonionic, such as polyacrylic acid sodium salt and calcium
Salt, lignin sulfonic acid sodium salt and calcium salt；With at least 12 carbon atom fatty acids or fatty amine and ethylene oxide and/or epoxy third
The polycondensation product of alkane；Glycerine, dodecanol -1, tetradecanol -1, sorbierite, sucrose or pentaerythritol fatty ester and they
With ethylene oxide and/or the polycondensation product of propylene oxide；The sulfate or sulfonate of the polycondensation product；With at least ten carbon
Atom alkyl sulfuric acid or sulfonate alkali metal or alkali salt, preferably sodium salt, as lauryl sodium sulfate, secondary alkyl sulfuric acid
Sodium, sulfonated castor oil sodium salt, alkylaryl sodium sulfonate or neopelex；Ethylene oxide polymer or ethylene oxide and ring
Ethylene Oxide copolymer.
Emulsifier that the present invention uses is allowed to shape it should be understood that one kind can improve each phase interfacial surface tension in emulsion
At the substance of uniform and stable dispersion or emulsion.It is every that there are these performances and agricultural bacteriocide of the present invention is not appointed
The chemical substance of what negative effect may be used to the present invention, they are all within protection scope of the present invention.
The emulsifier that the present invention uses is nonionic emulsifier.For example, the nonionic emulsifier is selected from polyoxy
Ethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether and Polyoxyethylene fatty ammonia, as ethoxylated castor oil, polyoxyethylene (n20) benzene
Ethyl phenolic group oleic acid ester, alkylaryl polyoxyethylene poly-oxygen propylene aether, alkylaryl formaldehyde resin polyoxyethylene ether, triphen second
Alkenyl phenol polyethenoxy (n20), ether phosphoric acid triethanolamine salt, Diphenethyl phenolic group polyoxyethylene ether (n18) formaldehyde condensation products,
Diphenyl phenol polyethenoxy (n18) polyethenoxy ether (n20) etc., these nonionic emulsifier are all current market sales of
Product, such as the polyoxyethylene (n by the offer of Jiangsu Kai Yuan Science and Technology Ltd.s20) phenethyl phenolic group oleic acid ester, alkylaryl
Formaldehyde resin polyoxyethylene ether, sale diphenyl phenol polyethenoxy (n18) polyethenoxy ether (n20).The emulsification that the present invention uses
Agent can be commercial emulsifier, such as agriculture breast 0201B, agriculture breast 0203B, agriculture breast 100#, agriculture breast 500#, agriculture breast 600#, agriculture breast 600-
2#, agriculture breast 1601, agriculture breast 2201, agriculture breast NP-10, agriculture breast NP-15, agriculture breast 507#, agriculture breast OX-635, agriculture breast OX-622, agriculture breast
OX-653, agriculture breast OX-667, agriculture breast CS-7 or peaceful breasts 36#。
Dispersant that the present invention uses is it should be understood that a kind of in the molecule while having lipophilic fraction and hydrophily portion
Point interfacial agent, it be it is a kind of will can be difficult to be dissolved in the solid in liquid evenly dispersed with liquid particles, simultaneously and also
It can be prevented to settle and agglomerate, form the substance of stable suspension.It is every to there are these performances and to agricultural bacteriocide of the present invention
There is no the chemical substance of any negative effect to may be used to the present invention, they are all within protection scope of the present invention.
The dispersant that the present invention uses is, for example, sodium lignin sulfonate, pull open powder, calcium lignosulfonate, methyl naphthalene sulfonic acid first
Aldehyde condensate, naphthalene sulfonic acid-formaldehyde condensation product, methanonaphthalene sodium sulfonate, oleic acid methylaminoethyl sodium sulfonate, epoxidized polyether, to uncle
Butyl ether, dibutyl naphthalenesulfonic acid formaldehyde condensation produc, phosphate such as calgon, alkylphenol-polyethenoxy based phosphates, alkyl
Phenol polyethenoxy base ether formaldehyde condensation products sulfate, the contracting of N- methyl-fatty acyl group-sodium taurocholate alkyl phenol polyoxyethylene ether formaldehyde
Close object, aralkyl phenol polyethenoxy ether phosphate alkyl phenol polyoxyethylene ether, castor oil ethylene oxide adduct, ethylene oxide-
Propylene oxide block copolymer APES formaldehyde condensation product, alkylphenol-polyethenoxy polyethenoxy ether and methyl are fine
Dimension element.
The dispersant that the present invention uses all is current market sales of product, such as by Nanjing Teva-Chem. Co., Ltd.
N- methyl-fatty acyl groups-sodium taurocholate the APES formaldehyde condensation product of sale, castor oil ethyleneoxide addition
Object, ethylene oxide-propylene oxide block copolymer APES formaldehyde condensation product, alkylphenol-polyethenoxy Ji Mijia
Aldehyde condensate sulfate.
The stabilizer that the present invention uses is, for example, sodium lignin sulfonate.The stabilizer that the present invention uses all is currently on the market
The product of sale, such as the lignin series of products sold by virtue Visco Co..
Wetting agent that the present invention uses it should be understood that one kind can reduce solid material surface tension or interfacial tension,
Water is easily spread out on the surface thereof and the substance that soaks solid material.It is every to there are these performances and to agricultural sterilization of the invention
Agent does not have the chemical substance of any negative effect to may be used to the present invention, they are all within protection scope of the present invention.
The wetting agent that the present invention uses is selected from sldium lauryl sulfate, alkylol polyoxyethylene base ether sodium sulfate, octylphenol polyethylene
Oxyethylene group ether sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, sodium alkyl sulfonate, dodecyl benzene sulfonic acid
Sodium, Negel, dialkyl succinylsuccinate sulfonate, lauryl alcohol polyethylene glycol oxide base ether sulfonic acid sodium, alkyl amide sodium taurocholate, fat
Fat alcohol polyoxyethylene ether, alkylphenol-polyethenoxy base ether, polyoxyethylene polyoxypropylene block polymer, sorbitan fatty
Acid esters polyoxyethylene ether etc..
The wetting agent that the present invention uses all is current market sales of product, such as is sold by Xing Fei Chemical Co., Ltd.s
Alkylol polyoxyethylene base ether sodium sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, lauryl alcohol polyethylene glycol oxide
Base ether sulfonic acid sodium, sorbitan fatty acid ester polyoxyethylene ether.
In addition to above-mentioned surfactant, the auxiliary agent that the present invention uses also has antifoaming agent, thickener, suspending agent and antifreezing agent.
The antifoaming agent that the present invention uses is it should be understood that a kind of substance with chemistry and surface chemistry defoaming effect.It is every
There is no the chemical substance of any negative effect to may be used to the present invention with these performances and to agricultural bacteriocide of the present invention, it
All within protection scope of the present invention.
The antifoaming agent is selected from bubble enemy, silicone, C8~10Fatty alcohol, C10~20Saturated fatty acid or amide antifoaming agent；
The antifoaming agent that the present invention uses all is current market sales of product, such as is sold by Nanjing Jie Run Co., Ltds
Bubble enemy, C10~20Saturated fatty acid, amide antifoaming agent.
Thickener that the present invention uses can be improved and be killed it should be understood that one kind can be such that agricultural bacteriocide of the present invention emulsifies
Microbial inoculum viscosity simultaneously reaches stable substance.It is every that there are these performances and do not have any negative shadow to agricultural bacteriocide of the present invention
Loud chemical substance may be used to the present invention, they are all within protection scope of the present invention.
The thickener is selected from carboxymethyl alcohol, polyvinyl alcohol, polyvinyl acetate, xanthans, gelatin, Arabic tree
Glue, polyvinylpyrrolidone, aluminum magnesium silicate, polyvinyl alcohol, polyethylene glycol, phenolic resin, shellac, carboxymethyl cellulose or seaweed
Sour sodium；
The thickener that the present invention uses all is current market sales of product, such as by Beijing Green Tai Mu Co., Ltds
Carboxymethyl alcohol, the polyvinylpyrrolidone of sale.
The suspending agent that the present invention uses is it should be understood that one kind can increase agricultural bacteriocide viscosity of the present invention to reduce
Wherein particle sinking speed or the increase hydrophilic substance of particle.It is every that there are these performances and do not have to agricultural bacteriocide of the present invention
There is the chemical substance of any negative effect to may be used to the present invention, they are all within protection scope of the present invention.
The suspending agent is selected from glycerine, Arabic gum, tragacanth, peach gum, methylcellulose, sodium carboxymethylcellulose
Or hydroxypropyl cellulose.
The suspending agent that the present invention uses all is current market sales of product, such as by Nanjing Guan Hua trade Co., Ltds
Xanthans, peach gum, the sodium carboxymethylcellulose of sale.
The antifreezing agent that the present invention uses is it should be understood that one kind can prevent agricultural bacteriocide of the present invention in microthermal climate ring
The substance freezed under border.It is every that there are these performances and do not have the chemistry of any negative effect to agricultural bacteriocide of the present invention
Substance may be used to the present invention, they are all within protection scope of the present invention.
The antifreezing agent is selected from glycerine, urea, ethylene glycol or propylene glycol.
The antifreezing agent that the present invention uses all is current market sales of product.
According to the present invention, the agricultural bacteriocide be water dispersion granule, wettable powder, suspending agent, dry suspending agent,
The dosage forms such as missible oil, aqueous emulsion or microemulsion.
Particularly, for water dispersible granules, those skilled in the art are very familiar with completes the present invention using corresponding auxiliary agent.It can
The auxiliary agent used is such as：Dispersant selects polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate；Wetting agent is selected from polyoxyethylene
Alcohol, alkyl sulfate, alkylsulfonate, naphthalene sulfonate；Disintegrant is selected from ammonium sulfate, urea, sucrose, glucose, aluminium chloride, lemon
Lemon acid, succinic acid, sodium bicarbonate；Binder is selected from diatomite, cornstarch, PVA, methylol (ethyl) cellulose family；Filler
Select diatomite, kaolin, white carbon, fine particle calcium carbonate, sepiolite, talcum powder, attapulgite, clay.
For wettable powder, workable auxiliary agent is such as：Dispersant selects polycarboxylate, lignosulfonates, alkylnaphthalene sulphur
Hydrochlorate；Wetting agent is selected from alkyl sulfate, alkylsulfonate, naphthalene sulfonate；Filler is selected from ammonium sulfate, urea, sucrose, grape
Sugar, diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, clay.
For suspending agent, workable auxiliary agent has：Dispersant selects polycarboxylate, lignosulfonates, alkyl naphthalene sulfonic acid
Salt, TERSPERSE 2425 (Huntsman Corporation of the U.S. produces, alkyl naphthalene sulfonic acid salt)；It is (general that emulsifier is selected from Nongru-700 #
Name：Alkyl phenol formaldehyde resin polyoxyethylene ether), agriculture breast 2201, this disk -60# (common names：Sorbitan monostearate), breast
Agent T-60 (common names：Sorbitan monostearate polyoxyethylene ether), 1601 (common name of agriculture breast：Phenethyl phenol is poly-
Ethylene oxide polyethenoxy ether), TERSPERSE 4894 (Huntsman Corporation of U.S. product)；Wetting agent is selected from alkylphenol-polyethenoxy
Poly- base ether formaldehyde condensation products sulfate, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyoxyethylene groups ether phosphate, alkane
Base sulfate, alkylsulfonate, naphthalene sulfonate, TERSPERSE 2500 (Huntsman Corporation of U.S. product)；Thickener is selected from Huang
Virgin rubber, polyvinyl alcohol, bentonite；Preservative is selected from formaldehyde, benzoic acid, sodium benzoate；Antifoaming agent is organic silicon antifoaming agent；It is anti-
Freeze agent and is selected from ethylene glycol, propylene glycol, glycerine, urea, inorganic salts such as sodium chloride.
For dry suspending agent, workable auxiliary agent has：Lignosulfite, soda pulping waste, animals and plants hydrolyze egg
In vain, soap, thermoplastic water-soluble base.
When agricultural bacteriocide of the present invention is water dispersible granules, preparation method is as follows：By active constituent Y14079, cyanogen frost
Azoles, powder carrier, wetting spreader-sticker and binder etc. carry out co-grinding, are added equipped with certain specification sieve after adding water to mediate
Be granulated in comminutor, then through drying, sieve up to granular product.
When agricultural bacteriocide of the present invention is suspending agent, preparation method is as follows：By dispersant, wetting agent, suspending agent and anti-
Freeze the mixing such as agent, is uniformly mixed using high speed shear, above-mentioned active constituent Y14079 and cyazofamid is then added, in ball crusher
Abrading-ball 2~3 hours, makes a diameter be below 5mm, and obtains the suspending agent.
When agricultural bacteriocide of the present invention is wettable powder, preparation method is as follows：By active constituent Y14079, cyanogen frost
Azoles, dispersant, wetting agent and filler mixing, uniform stirring, reuses air-flow crushing commonly used in the art in a stirring kettle
Machine remixes after crushing uniformly obtains the wettable powder.
When agricultural bacteriocide of the present invention is missible oil, preparation method is as follows：By solvent, emulsifier, active constituent Y14079
(being dissolved when necessary with heating water bath) is uniformly mixed to get to transparence missible oil with cyazofamid.
When agricultural bacteriocide of the present invention is aqueous emulsion, preparation method is as follows：By active constituent Y14079 and cyazofamid, molten
Agent, emulsifier, which are mixed evenly, is made into uniform oil phase, and by water, ethylene glycol mixing is made into water phase, in the condition of high shear
Under, oil phase is added slowly in water phase, you can obtain aqueous emulsion.
Conventional method application, such as injection, spraying may be used in bactericidal composition and fungicide of the present invention.Its amount of application can
To be changed according to weather conditions or crop growthing state, can be applied before or after disease occurs.Protective effect is held
The continuous time is usually related with the content of single compound in composition, also related to extraneous factor, such as weather, but by using
Dosage form appropriate can slow down the influence of weather.
Bactericidal composition and fungicide of the present invention can also be mixed with other compounds with weeding, insecticidal properties to be made
With can also be used in mixed way with protective agent, growth regulator, nutrient for plants or soil conditioner.
[advantageous effect]
Bactericidal composition of the present invention has following advantageous effects：
(1) compared with single dose, which has prevention cucumber downy mildew, tomato late blight and early blight of tomato aobvious
The synergistic effect of work, extends the lasting period, improves effect；Using the complex preparation of the present invention, 7d is to cucumber cream after administration
Mildew preventive effect reaches 83-90%, and 14d reaches 85-92% to preventive effect after administration, is significantly higher than the preventive effect of single dose.
(2) times for spraying is reduced, lowers drug cost, reduces environmental pollution and pesticide residue；
(3) composition is made of the active ingredient of different role mechanism, and action site increases, and is conducive to overcome and delay cause
The generation of germ drug resistance.The present composition is without obvious harmful effects to trial crops, and leaf color, growing way etc. are all normal, peace
Good perfection meets the security requirement of pesticidal preparations.
Bactericidal composition of the present invention has cucumber downy mildew, tomato late blight and/or early blight of tomato good
Preventive effect.
【Specific implementation mode】
The present invention is will be better understood that by following embodiments.
One, the preparation of agricultural bacteriocide of the present invention
Embodiment 1：Prepare 50%Y14079 cyazofamid water-dispersible granules
It weighs with 40% chemical constitution formula (I) Y14079 of wettable powder total weight, 10% cyazofamid, N- methyl-oil
Acyl group-sodium taurocholate 8%, naphtholsulfonic acid formaldehyde condensation products 10%, soluble starch 8%, sodium sulphate 10%, kaolin complements to
100%, obtain fungicide according to preparation method above-mentioned.
Embodiment 2：Prepare 60%Y14079 cyazofamid wettable powders
It weighs with 40% chemical constitution formula (I) Y14079 of wettable powder total weight, 20% cyazofamid, lignin sulfonic acid
Sodium 15%, methyl naphthalene sulfonate formaldehyde condensate 5%, epoxidized polyether 5%, bentonite 10%, kaolin complements to 100%, presses
Wettable powdered disinfectant is obtained according to preparation method above-mentioned.
Embodiment 3：Prepare 30%Y14079 cyazofamid suspending agents
It weighs with 20% chemical constitution formula (I) Y14079 of total weight, 10% cyazofamid, sodium lignin sulfonate 5%, white carbon
Black 0.3%, the mixture (EFW) 2.0% of alkylnaphthalene sulfonate and anion wetting agent, potassium dihydrogen phosphate 0.2%, ethylene glycol
4%, tributyl phosphate 0.2%, water complements to 100%, and suspending agent fungicide is obtained according to preparation method above-mentioned.
Embodiment 4：Prepare 25%Y14079 cyazofamid suspending agents
It weighs with 20% chemical constitution formula (I) Y14079 of total weight, 5% cyazofamid, the condensation of methyl naphthalene sulfonic acid sodium formaldehyde
The mixture (EFW) 2.0% of object 2.5%, alkylnaphthalene sulfonate and anion wetting agent, agriculture breast OX-6563.0%, glycerine
4%, tributyl phosphate 0.2%, water complements to 100%, and suspending agent fungicide of the present invention is obtained according to preparation method above-mentioned.
Embodiment 5：Prepare 30%Y14079 cyazofamid wettable powders
It weighs with 25% chemical constitution formula (I) Y14079 of total weight, 5% cyazofamid, neopelex
1.8%, to tertbutyl ether 2%, White Carbon black 10%, sodium lignin sulfonate 10%, precipitated calcium carbonate complements to 100%, according to preceding
The preparation method stated obtains Wettable powdered disinfectant.
Embodiment 6：Prepare 60%Y14079 cyazofamid wettable powders
It weighs with 40% chemical constitution formula (I) Y14079 of total weight, 20% cyazofamid, neopelex 2%,
To tertbutyl ether 2%, White Carbon black 5%, sodium lignin sulfonate 10%, precipitated calcium carbonate complements to 100%, according to preparation above-mentioned
Method obtains fungicide wettable powder of the present invention.
Embodiment 7：Prepare 15%Y14079 cyazofamid missible oil
It weighs with 12% chemical constitution formula (I) Y14079 of total weight, 3% cyazofamid, agriculture breast 0203B 6%, agriculture breast
0201B 9%, cyclohexanone 8%, solvent naphtha 150 complement to 100%, and fungicide breast of the present invention is obtained according to preparation method above-mentioned
Oil.
Embodiment 8：Prepare 50%Y14079 cyazofamid missible oil
It weighs with 40% chemical constitution formula (I) Y14079 of total weight, 10% cyazofamid, agriculture breast 2201#6%, agriculture breast
0201B 8%, cyclohexanone 8%, solvent naphtha 150 complement to 100%, and fungicide breast of the present invention is obtained according to preparation method above-mentioned
Oil.
Embodiment 9：Prepare 20%Y14079 cyazofamid aqueous emulsions
It weighs with 15% chemical constitution formula (I) Y14079 of total weight, 5% cyazofamid, solvent naphtha S-150 30%, triphen
Ethyl phenol polyoxyethylene ether phosphate 3%, styrylphenol formaldehyde resin Polyoxyethylene polyoxypropylene ether 5%, propylene glycol
3%, water is mended to 100%, and disinfectant aqueous emulsion of the present invention is obtained according to preparation method above-mentioned.
Embodiment 10：Prepare 35%Y14079 cyazofamid aqueous emulsions
It weighs with 5% chemical constitution formula (I) Y14079 of total weight, 30% cyazofamid, solvent naphtha S-150 30%, triphen
Ethyl phenol polyoxyethylene ether phosphate 4%, terminal hydroxy group polyoxyethylene poly-oxygen propylene aether block copolymer 5%, ethylene glycol 3%, water
It mends to 100%, disinfectant aqueous emulsion of the present invention is obtained according to preparation method above-mentioned.
Embodiment 11：Prepare 25%Y14079 cyazofamid microemulsions
It weighs with 5% chemical constitution formula (I) Y14079 of total weight, 20% cyazofamid, isopropanol 10%, solvent naphtha S-
150 15%, calcium dodecyl benzene sulfonate 2%, styryl phenyl polyoxyethylene ether 19%, water mends to 100%, according to aforementioned
Preparation method obtain fungicide microemulsion of the present invention.
Embodiment 12：Prepare 20%Y14079 cyazofamid microemulsions
It weighs with 10% chemical constitution formula (I) Y14079 of total weight, 10% cyazofamid, n-octylpyrrolidone 6%, it is molten
Agent oil S-150 15%, calcium dodecyl benzene sulfonate 2%, alkyl phenol formaldehyde resin polyoxyethylene ether 16%, water are mended to 100%,
Fungicide microemulsion of the present invention is obtained according to preparation method above-mentioned.
Embodiment 13：Prepare 0.5%Y14079 cyazofamid suspending agents
It weighs with 0.25% chemical constitution formula (I) Y14079 of total weight, 0.25% cyazofamid, 4% phenethyl phenol polyoxy
It ethylene polyethenoxy ether, 1.8% aluminum magnesium silicate, 1% xanthans, 3% propylene glycol polyoxyethylene poly-oxygen propylene aether and is supplemented to
100% water obtains bactericide suspending agent of the present invention according to preparation method above-mentioned.
Two, the measurement of bioactivity
In order to further appreciate that the virulence of Y14079 and cyazofamid composition, a large amount of formulation screening tests have been carried out.
Bioassay example 1：Y14079 compounds the Toxicity Determination to cucumber downy mildew with cyazofamid
Subjects cucumber downy mildew (Pseudoperonospora cubensis) is by indoor long-term live body culture.
Test method reference《National Standard of the People's Republic of China GB/T 17980.26-2000》, using spore suspension
Spray inoculation method measures the bioactivity of medicament.The potting cucumber seedling for selecting growing way consistent, naturally dry after reagent spray processing,
Distillation washing is dipped with writing brush afterwards for 24 hours and take disease leaf back sporangium, be made into sporangia suspension (2-3 × 105A/ml), with connecing
Sporangia suspension is uniformly sprayed on cucumber leaves by kind sprayer (pressure 0.1MPa), then moves to cucumber seedling after inoculation
(relative humidity 100%, temperature are 21-23 DEG C, light dark period 14h/10h) culture in artificial climate room.Maintain phase afterwards for 24 hours
90% or so moisturizing of humidity is induced, 7-8d backsight blank control incidences carry out classification investigation, refer to by disease and calculate preventive effect %.
The EC of each medicament is found out by control effect50, co-toxicity coefficient (CTC) is calculated further according to Sun Yunpei's Method.
Investigation method and grade scale:
0 grade：It is disease-free；
1 grade：Lesion area accounts for 5% or less full wafer leaf area；
3 grades：Lesion area accounts for the 6%~10% of full wafer leaf area；
5 grades：Lesion area accounts for the 11%~20% of full wafer leaf area；
7 grades：Lesion area accounts for the 21%~40% of full wafer leaf area；
9 grades：Lesion area accounts for 40% or more of full wafer leaf area.
Computational methods：
1 Y14079 of table compounds the The Toxicity Determination result to cucumber downy mildew with cyazofamid
Bioassay example 2：Y14079 compounds the Toxicity Determination to tomato late blight, early blight of tomato with cyazofamid
Subjects tomato late blight (Phytophthora infestans), early blight of tomato
(A.solanisorauer) by laboratory long-term preservation.
Test method reference《People's Republic of China (PRC) agricultural industry criteria NY/T 1156.2-2006》, grown using mycelia
Performance rate method measures the bioactivity of medicament.5 dosage processing are respectively set by active constituent content in each medicament, by above-mentioned cause of disease
Bacterium PDA culture medium culture breaks into fungus block with the card punch of diameter 5cm when bacterium colony just covers with culture medium in colony edge, uses
Transfer needle says that fungus block moves to toxic PDA culture medium center and often handles 4 repetitions then as being cultivated in 25 DEG C of incubators.Depending on CK
Bacterium colony growing state measures each processing colony diameter using crossing method slide calliper rule, finds out correction and inhibit percentage.Pass through
Linear regression analysis between the probit value of inhibiting rate and the logarithm of series concentration finds out the EC of each medicament50, further according to
Sun Yunpei's Method calculates co-toxicity coefficient (CTC).
Drug effect calculates：Two diameters are surveyed in each bacterium colony right-angled intersection, and bacterium colony size is represented with its average.It finds out as the following formula
Bacterium colony growth inhibition ratio：Bacterium colony growth inhibition ratio %=(blank control bacterium colony increases diameter-chemicals treatment bacterium colony and increases diameter)
× 100/ blank control bacterium colony increases diameter.
2 Y14079 of table compounds the The Toxicity Determination result to tomato late blight with cyazofamid
3 Y14079 of table compounds the The Toxicity Determination result to early blight of tomato with cyazofamid
| Medicament | EC50(mg/L) | Actual measurement poison refers to | Theoretical poison refers to | Co-toxicity coefficient |
| Y14079(A) | 3.47 | 100.00 | ||
| Cyazofamid (B) | 2.66 | 130.45 | ||
| A:B(50：1) | 3.03 | 114.52 | 100.60 | 113.84 |
| A:B(10：1) | 2.47 | 140.49 | 102.77 | 136.70 |
| A:B(8：1) | 2.77 | 125.27 | 103.38 | 121.17 |
| A:B(4：1) | 1.95 | 177.95 | 106.09 | 167.73 |
| A:B(2：1) | 2.41 | 143.98 | 110.15 | 130.72 |
| A:B(1：2) | 1.89 | 183.60 | 120.30 | 152.62 |
| A:B(1：4) | 1.73 | 200.58 | 124.36 | 161.29 |
| A:B(1：8) | 1.64 | 211.59 | 127.07 | 166.52 |
| A:B(1：10) | 1.97 | 176.14 | 127.68 | 137.95 |
| A:B(1：50) | 2.36 | 147.03 | 129.85 | 113.23 |
Three, Field information is tested
Field trial 1：Prevent cucumber downy mildew field control effectiveness test
Cucumber downy mildew field control effectiveness test is prevented with reference to National Standard of the People's Republic of China " GB/T 17980.26-
2000 " --- the regulation of bactericidal agent for preventing and treating cucumber downy mildew carries out, test medicine, comparison medicament and the processing of the cell of blank control
It is arranged using random district's groups, 15 ㎡ of plot area, 4 repetitions, this experiment is total to dispenser twice.First time dispenser is in morbidity just
Phase applies second of medicine after a week.The total investigation of this experiment 2 times investigates 2 plants at every per experimental plot using random 4 points samplings,
Every plant of whole blades are investigated, disease grade is recorded.
Disease scale standard is as follows：
0 grade：It is disease-free；
1 grade：Lesion area accounts for 5% or less full wafer leaf area；
3 grades：Lesion area accounts for the 6%~10% of full wafer leaf area；
5 grades：Lesion area accounts for the 11%~20% of full wafer leaf area；
7 grades：Lesion area accounts for the 21%~40% of full wafer leaf area；
9 grades：Lesion area accounts for 40% or more of full wafer leaf area.
Computational methods：
In formula：CK0--- disease index before blank district dispenser；
CK1--- disease index after blank district dispenser；
PT0--- disease index before chemicals treatment district dispenser；
PT1--- disease index after chemicals treatment district dispenser.
4 Y14079 of table compounds the field control effectiveness test result to cucumber downy mildew with cyazofamid
Field trial 1, prevention early blight of tomato and late blight field control effectiveness test
The test of pesticide effectiveness is with reference to National Standard of the People's Republic of China's " GB/T 17980.31-2000 --- bactericidal agent for preventing and treating kind
The regulation of eggplant early blight and late blight " carries out, and test medicine, comparison medicament and the processing of the cell of blank control use random district's groups
Arrangement, 20 ㎡ of plot area, 4 repetitions, this experiment are total to dispenser twice.First time dispenser is in early stage, applies after a week
Secondary medicine.The total investigation of this experiment 2 times investigates 2 plants at every per experimental plot using random 5 points samplings, and every plant is divided upper, middle and lower
10 blades are investigated, disease grade is recorded.
Disease scale standard is as follows：
0 grade：It is disease-free；
1 grade：Lesion area accounts for 5% or less full wafer leaf area；
3 grades：Lesion area accounts for the 6%~10% of full wafer leaf area；
5 grades：Lesion area accounts for the 11%~20% of full wafer leaf area；
7 grades：Lesion area accounts for the 21%~50% of full wafer leaf area；
9 grades：Lesion area accounts for 50% or more of full wafer leaf area.
Computational methods：
In formula：
CK0 --- disease index before blank district dispenser；
CK1 --- disease index after blank district dispenser；
PT0 --- disease index before chemicals treatment district dispenser；
PT1 --- disease index after chemicals treatment district dispenser.
5 Y14079 of table compounds the field test results to tomato late blight with cyazofamid
6 Y14079 of table compounds the field test results to early blight of tomato with cyazofamid
From above-mentioned field trial (table 4,5,6) result can be seen that Y14079 and cyazofamid compounding after can effectively anti-Yellow River harnessing
Melon downy mildew, tomato late blight and early blight of tomato, compared with single dose, which has significant synergy to make disease
With improving bactericidal effect；
Times for spraying is reduced, drug cost is reduced, reduces the pollution to environment and pesticide residue；
Composition is conducive to overcome and delay the drug resistance of germ since different mechanism of action, action site increase
It generates.The present composition is without obvious harmful effects to trial crops, and leaf color, growing way etc. are all normal, and safety is good, meets agriculture
The security requirement of medicine preparation.
Plurality of plant diseases especially downy mildew, early blight of the bactericidal composition of the present invention to flowers, fruit tree, vegetables
There is good preventive effect with late blight.
Claims (7)
1. a kind of agricultural bactericidal composition, it is characterised in that it is by compound and cyazofamid with following chemical constitution formula (I)s
According to weight ratio 50:1~1:50 compositions：
2. agricultural bactericidal composition according to claim 1, it is characterised in that chemical constitution formula (I) compound and cyazofamid
Weight ratio be 10:1~1:10.
3. a kind of agricultural bacteriocide, it is characterised in that it contains 0.5~95.0% according to claim 1 or claim 2 by weight
Agriculture bactericidal composition and surplus be agriculturally acceptable carrier and auxiliary agent.
4. agricultural bacteriocide according to claim 3, it is characterised in that it contains by weight 10~60% according to right
It is required that the agriculture bactericidal composition and surplus described in 1 or 3 are agriculturally acceptable carrier and auxiliary agent.
5. agricultural bacteriocide according to claim 3 or 4, it is characterised in that its dosage form is water dispersion granule, wettable
Property pulvis, suspending agent, dry suspending agent, missible oil, aqueous emulsion or microemulsion.
6. agricultural bactericidal composition or according to described in any one of claim 3-5 claims according to claim 1 or claim 2
Purposes of the agricultural bacteriocide in prevention cucumber downy mildew, tomato late blight and/or early blight of tomato.
7. it is a kind of prevention crop disease method, before or after crops and/or fruit introduced disease, to crops and/
Or fruit and the place of growth or storage are applied and are appointed in agriculture bactericidal composition or claim 3-5 described in claims 1 or 2
Agricultural bacteriocide described in one claim.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105693638A (en) * | 2016-01-05 | 2016-06-22 | 华中师范大学 | Bactericidal compound and bactericide composition and preparation and application thereof |
| CN108184854A (en) * | 2017-12-31 | 2018-06-22 | 成都格瑞赛斯科技有限公司 | A kind of bactericidal composition and its application containing cyazofamid |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105693638A (en) * | 2016-01-05 | 2016-06-22 | 华中师范大学 | Bactericidal compound and bactericide composition and preparation and application thereof |
| CN108184854A (en) * | 2017-12-31 | 2018-06-22 | 成都格瑞赛斯科技有限公司 | A kind of bactericidal composition and its application containing cyazofamid |
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