CN108347930A - Powdered anthelmintic composition and its manufacturing method - Google Patents
Powdered anthelmintic composition and its manufacturing method Download PDFInfo
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- CN108347930A CN108347930A CN201680064957.XA CN201680064957A CN108347930A CN 108347930 A CN108347930 A CN 108347930A CN 201680064957 A CN201680064957 A CN 201680064957A CN 108347930 A CN108347930 A CN 108347930A
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- Prior art keywords
- powdered
- active ingredient
- anthelmintic composition
- oil absorbent
- talcum
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
- A01M29/00—Scaring or repelling devices, e.g. bird-scaring apparatus
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/16—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
Abstract
Form as insect repellent article is to be conceived to powder type, provide a kind of anthelminthic effect and it is excellent to the safety of human body or animal be self-evident, and the also satisfactory non-alcoholic powdered anthelmintic composition in terms of use feeling or duration.A kind of powdered anthelmintic composition, contains：To be selected from least one of group being made of Metadelphene, 3 (N normal-butyl N acetyl group) alanine ethyl ester and Icaridins as the pest repellant of active ingredient；Stimulation moderator using ethylene glycol series solvent as active ingredient；Using talcum as the water retention agent of active ingredient；And the oil absorbent using silicate compound as active ingredient, the ratio between the use level (a) of above-mentioned water retention agent and the use level (b) of above-mentioned oil absorbent (a: b) are with weight ratio meter for 3: 1~20: 1.
Description
Technical field
The present invention relates to the powder to protect human body or animal to be invaded and harassed from pests such as mosquito, buffalo gnat, thorn fly, family's dust mite, bedbugs
Last shape anthelmintic composition and its manufacturing method.
Background technology
Previous insect repellent article is the product of the atomizing (aerosol type) using alcohol as base as mainstream.Such as make
For previous aerosol insect repellent article, it is known to patent document 1 and patent document 2.The anthelmintic composition of patent document 1 be with
Specific ratio cooperation inorganic powder or organic dust and silicic acid anhydride, it is filled in together with anthelmintic ingredient, alcohol, propellant
Automiser spray.The repellant compositions of patent document 2 are that pest repellant is made to support in silicic acid anhydride small porous particle, itself and synthesis are set
Fat particle, alcohol, propellant are filled in automiser spray together.Moreover, as the insect repellent article in addition to atomizing, also developed as
The product of hygenic towelette formula as patent document 3 (wet tissue type).The pest repellant of patent document 3 is to make silicic acid chemical combination
Object, anthelmintic ingredient, alcohol are infiltrated in non-woven fabrics.
Existing technical literature
Patent document
Patent document 1：Japanese Unexamined Patent Publication 11-302102 bulletins
Patent document 2：Japanese Unexamined Patent Publication 2000-63201 bulletins
Patent document 3：Japanese Unexamined Patent Publication 2001-270802 bulletins
Invention content
Problems to be solved by the invention
However, aerosol insect repellent article is due to making anthelmintic ingredient micronized as patent document 1 and patent document 2
And it is sprayed to skin surface, therefore easy to produce the crawling of coated face.It is not attached to skin as a result, having and generating medicament
Part slightly the case where, have incurs the biting of mosquito, the risk of Blood feeding behaviour in this slightly part.Moreover, having because of packet
The case where the dispersing and schneiderian membrane made to feel stimulation of anthelmintic composition (medicament) of containing alcohol or anthelmintic ingredient, in terms of use feeling
It needs to be improved.The pest repellant of patent document 3 is not because being atomizing, therefore the problem of dispersing of medicament is few, but because with patent document 1 and
The insect repellent article of patent document 2 is used in the same manner alcohol, therefore is used for still difficult for stimulating the people of allergy to alcohol etc..
Due to these reasons, medicament difficulty is required to disperse recently, the demand without using the insect repellent article of the type of alcohol is increasing
Add.The present invention makes in view of the above problems, and the product form as anthelmintic composition is to be conceived to powder type, mesh
Be to provide a kind of anthelminthic effect and it is excellent to the safety of human body or animal be self-evident, and in use feeling or continue
Property aspect also satisfactory non-alcoholic powdered anthelmintic composition and its manufacturing method.
The means used to solve the problem
The feature composition of powdered anthelmintic composition of the present invention for solving the above problems is：
A kind of powdered anthelmintic composition, contains：
To be selected from by Metadelphene (DEET), 3- (N- normal-butyl-N- acetyl group) alanine ethyl esters and Icaridin
(icaridin) pest repellant of at least one of the group formed as active ingredient；
Stimulation moderator using ethylene glycol series solvent as active ingredient；
Using talcum as the water retention agent of active ingredient；And
Oil absorbent using silicate compound as active ingredient,
The ratio between the use level (a) of above-mentioned water retention agent and the use level (b) of above-mentioned oil absorbent (a: b) are with weight ratio
It is calculated as 3: 1~20: 1.
According to the powdered anthelmintic composition of this composition, because with above-mentioned suitable match ratio include using talcum as effectively at
Point water retention agent and oil absorbent using silicate compound as active ingredient, therefore user is by powdered expelling parasite
When composition is coated on skin, since the oils such as sebum are moderately absorbed by silicate compound, and talcum moderately keeps moisture,
To the sense of touch moistened while inhibiting tacky.Moreover, because talcum and silicate compound are stable substance, therefore nothing
The risk for weakening the effect of pest repellant complements each other with the effect of stimulation moderator and becomes the low system stimulated and repellent effect is high
Product.
In powdered anthelmintic composition of the present invention, preferably above-mentioned ethylene glycol series solvent is 1,3-BDO.
It can be real by using 1,3-BDO as ethylene glycol series solvent according to the powdered anthelmintic composition of this composition
Existing excellent use feeling, and stimulation alleviation effects especially can be improved.
In powdered anthelmintic composition of the present invention, preferably above-mentioned talcum measures apparent according to JIS K5101
Proportion (apparent specific gravity) is 0.4~0.6g/cc.
According to the powdered anthelmintic composition of this composition, because the apparent specific gravity of talcum is located at above-mentioned suitable range, therefore
Moisture is moderately kept by talcum, and more moist feeling can be obtained.
In powdered anthelmintic composition of the present invention, the average grain diameter of preferably above-mentioned talcum is 20 μm or more.
According to the powdered anthelmintic composition of this composition, by making the average grain diameter of talcum be 20 μm or more so that talcum
It can be certainly attached to skin, more moist feeling can be obtained.
In powdered anthelmintic composition of the present invention, preferably above-mentioned silicate compound is silicic acid anhydride.
According to the powdered anthelmintic composition of this composition, by using silicic acid anhydride as silicate compound so that oil
Absorbability become especially good, become the effective product that sticky feeling can be reduced for the people more than sebum.
In powdered anthelmintic composition of the present invention, the specific surface area of preferably above-mentioned silicate compound is 5~
100m2/g。
According to the powdered anthelmintic composition of this composition, because the specific surface area of silicate compound is located at above-mentioned suitable model
It encloses, therefore can efficiently absorb the oils such as sebum.
In powdered anthelmintic composition of the present invention, alcohol is not preferably included.
According to the powdered anthelmintic composition of this composition, due to not including alcohol, even the people to stimulating allergy
It can feel at ease to use.
The feature of manufacturing method for the powdered anthelmintic composition of the present invention to solve the above problems is formed in
In：
A kind of manufacturing method of powdered anthelmintic composition, including：
It will be made of Metadelphene, 3- (N- normal-butyl-N- acetyl group) alanine ethyl esters and Icaridin with being selected from
Stimulation moderator of at least one of the group as the pest repellant of active ingredient and using ethylene glycol series solvent as active ingredient is mixed
The mixed processes of conjunction；
The oil that the mixture obtained by above-mentioned mixed processes is absorbed in using silicate compound as active ingredient is set to inhale
Receive the absorption process of agent；
Water retention agent using talcum as active ingredient is made an addition to the oil absorbent that above-mentioned absorption process is completed
Addition process；And
The agitating procedure that the mixture of each ingredient obtained by above-mentioned addition process is stirred,
The additive amount (a) of above-mentioned water retention agent in above-mentioned addition process is inhaled with the above-mentioned oil in above-mentioned absorption process
The ratio between the usage amount (b) of agent (a: b) is received with weight ratio meter as 3: 1~20: 1.
According to the manufacturing method of the powdered anthelmintic composition of this composition, may achieve and above-mentioned powdered anthelmintic composition
Same excellent effect effect.That is, because addition process in the water retention agent using talcum as active ingredient additive amount and
The usage amount for absorbing the oil absorbent using silicate compound as active ingredient in process is set to above-mentioned suitable weight
Ratio is measured, therefore when the powdered anthelmintic composition that will obtain by subsequent agitating procedure of user is coated on skin, due to skin
The oils such as fat are moderately absorbed by silicate compound, and talcum moderately keeps moisture, to be obtained while inhibiting tacky
The sense of touch of moistening.Moreover, because talcum and silicate compound are stable substance, therefore the risk of the effect without decrease pest repellant,
It complements each other with the effect of stimulation moderator and the low product stimulated and repellent effect is high can be manufactured.
Specific implementation mode
The present invention powdered anthelmintic composition contain (1) pest repellant, (2) stimulation moderator, (3) water retention agent and
(4) oil absorbent is as basic ingredient.On the other hand, powdered anthelmintic composition of the invention does not include ethyl alcohol, isopropyl
The alcohol such as alcohol, propyl alcohol.Each ingredient of the powdered anthelmintic composition of the present invention is described in detail below.
(1) pest repellant
Pest repellant is the substance for having repellent action or inhibition of sucking blood to pest.Example as pest repellant can be lifted
Go out：Metadelphene, 3- (N- normal-butyl-N- acetyl group) alanine ethyl ester, Icaridin, Pai Karuiding (picaridin), lemongrass
Aldehyde (citronellal), citronellol (citronellol), citral (citral), linalool (linalool), terpineol
(terpineol), menthol (menthol), to terpane -3,8- glycol (p-menthane-3,8-diol), australene (α -
Pinene), the synthesis such as camphor (camphor), geraniol (geraniol), carane -3,4- glycol (carane-3,4-diol)
Close object.Moreover, could be used that cassia bark, lemongrass (citronella), lemon grass (Cymbopogon citratus) (lemongrass), clover (clover), perfume
The natural products such as lemon (bergamot), bay tree, eucalyptus (eucalyptus).Natural products can be with shapes such as essential oil or extract liquors
State uses., it is preferable to use Metadelphene, 3- (N- normal-butyl-N- acetyl group) alanine ethyl ester among the above-mentioned pest repellant listed
And Icaridin.Metadelphene has uses actual achievement for many years.3- (N- normal-butyl-N- acetyl group) alanine ethyl ester has and keeps away mosquito
The substantially same repellent effect of amine, and it is higher than Metadelphene to the safety of human body.The anthelminthic effect of Icaridin is high, safety
Also high.It should be noted that the above-mentioned each pest repellant listed both can be used alone, can also be made with two or more mixtures
With.The use level of pest repellant is set as relative to all amounts of powdered anthelmintic composition being 1~15 weight %, and preferably 3~14
Weight %, more preferably 6~12 weight %.In the case that use level is less than 1 weight %, it is unable to get sufficient anthelmintic action
Risk.In the case that use level is more than 15 weight %, having stimulates too strong risk.
(2) moderator is stimulated
The substance that stimulation moderator adds for the stimulation for mitigating to skin as caused by pest repellant.It is slow as stimulation
And agent, use ethylene glycol series solvent.Ethylene glycol series solvent is preferably C3~C6Ethylene glycol, such as can enumerate：Diethylene glycol, third
Glycol, dipropylene glycol, 1,3-BDO etc..Among these, more preferably using the high 1,3-BDO of stimulation abirritation.In passing
One carries, using 1,3-BDO as the C of representative3~C6Ethylene glycol absorbed from skin because itself being difficult to, therefore to mitigate pest repellant
Percutaneous absorbtion it is also effective.It should be noted that the above-mentioned ethylene glycol series solvent listed both can be used alone, it also can be with two kinds
Above mixture uses.The use level of stimulation moderator is set as relative to all amounts of powdered anthelmintic composition being 1~15
Weight %, preferably 5~10 weight %, more preferably 6~8 weight %.In the case that use level is less than 1 weight %, having can not
Fully mitigate the risk of the stimulation of pest repellant.In the case that use level is more than 15 weight %, have because of a large amount of ethylene glycol system
Solvent and so that sticky feeling is increased, use feeling deteriorate the case where.
(3) water retention agent
Water retention agent is the substance that adds of sense of touch (so-called moist feeling) for generating moistening.As water tariff collection
Agent uses talcum.Talcum is preferably 0.4~0.6g/cc according to the JIS K5101 apparent specific gravities measured.Apparent specific gravity is less than
In the case of 0.4g/cc, have sticky feeling and be also strongly felt than moist feeling, use feeling deteriorate the case where.Apparent specific gravity is big
In the case of 0.6g/cc, dry feeling becomes strong, there is the possibility of powder falling.Moreover, the average grain diameter of talcum be preferably 20 μm with
On.By the way that average grain diameter is set as 20 μm or more so that talcum can certainly be attached to skin, and more moist feeling can be obtained.It is average
In the case that grain size is less than 20 μm, anthelmintic composition is white and notable when being coated on skin, has and generates so-called white residual
The situation of object.It should be noted that talcum can also make in the state of being mixed with other inorganic powders such as kaolin, bentonite
With.The use level of water retention agent is set as relative to all amounts of powdered anthelmintic composition being 50~90 weight %, preferably
55~85 weight %, more preferably 63~83.5 weight %.In the case that use level is less than 50 weight %, because being unable to fully protect
Water holding point, therefore have the risk that powder falling occurs.In the case that use level is more than 90 weight %, it is also stronger than moist feeling to have sticky feeling
Feel strongly, use feeling deteriorate the case where.
(4) oil absorbent
Oil absorbent is the substance that is added for absorbing the oils such as sebum.As oil absorbent, using silicifying
Close object.Silicate compound can be enumerated：Silicic acid anhydride, calcium silicates, hydrophobic silica, diatomite etc..Among these, more preferably
Use the high silicic acid anhydride of oil assimilation effect.The specific surface area of silicate compound is preferably 5~100m2/g.Specific surface area is small
In 5m2In the case of/g, oil absorbability is insufficient and easy tos produce tacky.Specific surface area is more than 100m2In the case of/g, do
Refreshing sense becomes strong, there is the possibility of powder falling.It should be noted that the above-mentioned silicate compound listed both can be used alone, also can
It is used with two or more mixtures.The use level of oil absorbent is set as
1~50 weight %, preferably 3~30 weight %, more preferably 4.5~21 weight %.Use level is less than the case where 1 weight %
Under, oil absorbability is insufficient, easy tos produce tacky.In the case that use level is more than 50 weight %, oil absorbability is had
Surplus feels the case where thick and heavy and use feeling deteriorates.
The powdered anthelmintic composition of the present invention is with above-mentioned (1) pest repellant, (2) stimulation moderator, (3) water tariff collection
Agent and (4) oil absorbent are raw material, such as can be manufactured by sequence below.
First, pest repellant and stimulation moderator (mixed processes) are mixed.Then, make the mixture obtained by mixed processes
It is absorbed in oil absorbent (absorbing process).In turn, water retention agent is made an addition to the oil absorbent for being completed and absorbing process
(addition process).Finally, (agitating procedure) will be stirred by the mixture for adding each ingredient that process obtains.Complete this as a result,
The powdered anthelmintic composition of invention.
Herein, the use level about each ingredient of powdered anthelmintic composition, present inventor has performed trial and errors, as a result sentence
It is bright：Ensure anthelminthic effect and to the excellent product of the safety of human body or animal and use feeling and duration, general to be made
It is especially the use level of water retention agent among above-mentioned each ingredient and the use level of oil absorbent is set as suitable ratio
It is critically important.Specifically, setting the use level (additive amount) of water retention agent as a, if the use level (usage amount) of oil absorbent
For b, then the ratio between the use level of water retention agent and the use level of oil absorbent (a: b) be set as with weight ratio meter be 3: 1~
20: 1, preferably 3: 1~19: 1.In the case that match ratio is less than 3: 1, i.e., the use level of water retention agent is absorbed far fewer than oil
In the case of the use level of agent, moisture because being unable to fully is kept, therefore has the risk that powder falling occurs.Match ratio is more than 20: 1
In the case of, i.e., the use level of water retention agent far more than oil absorbent use level in the case of, have sticky feeling than moistening
The case where sense is also strongly felt, and use feeling deteriorates.If match ratio is set as above-mentioned suitable range, user is by powder
When last shape anthelmintic composition is coated on skin, since the oils such as sebum are moderately absorbed by silicate compound, and talcum is moderately
Moisture is kept, to the sense of touch moistened while inhibiting tacky.Moreover, because talcum and silicate compound are stable object
Matter, therefore without the risk for the effect for weakening pest repellant, complement each other with the effect of stimulation moderator and become low stimulation and repellent
The high product of effect.
As long as not hindering each effect of pest repellant, stimulation moderator, water retention agent and oil absorbent, powder of the invention
Last shape anthelmintic composition can also include other ingredients.The example of this ingredient can enumerate ultra-violet absorber, ultraviolet light dissipates
Penetrate agent, gloss agent, other powder, antiphlogistic, antiperspirant, moisturizer, surfactant, dispersant, fragrance etc..
It can be enumerated as ultra-violet absorber and ultraviolet light scattering diluent：P-aminobenzoic acid, amyl salicylate, Chinese cassia tree are misery
Ester, octyl methoxycinnamate, 2,4-DihydroxyBenzophenone, oxidation Titanium, zinc oxide etc..It can be enumerated as antiphlogistic：Radix Glycyrrhizae
Sour dipotassium, allantoin, alkyl trimethyl ammonium chloride, tocopherol acetate, camphor etc..It can be enumerated as antiperspirant：Aluminum sulfate, chlorine
Hydroxy Al, zinc phenolsulfonate etc..It can be enumerated as gloss agent：Film (such as by aluminium-vapour deposition in polyethylene terephthalate
Gold is deposited the stacked film in the film of polyethylene terephthalate, polyethylene terephthalate and polyolefin, is poly- by film
The layer of the stacked film of ethylene glycol terephthalate and polymethyl methacrylate, polyethylene terephthalate and polyethylene
Folded film) thin part；The natural micas powder such as white mica powder, phlogopite powder；Natural mica powder is melted into the synthesis after removing impurity
Mica powder；Titanium oxide is mixed in the mineral substances such as the mica titanium after mica powder；Ethylene glycol monostearate, ethylene glycol distearyl acid
The polyalcohols esters such as ester, triethylene glycol distearate；The agar capsule etc. of interior packet pigment.Moreover, also can be in powdered expelling parasite
Coordinate the organic dusts such as modified starch, silk fiber powder in composition.
The powdered anthelmintic composition of the obtained present invention become to pest (especially mosquito, buffalo gnat, thorn fly, family's dust mite,
The pests such as bedbug) repellent effect it is high and excellent to the safety of human body or animal, in terms of use feeling or duration
Also satisfactory insect repellent article.Moreover, alcohol is not used completely in the powdered anthelmintic composition of the present invention, even therefore
It can also feel at ease to use to the people of the allergy such as alcohol.
Embodiment
The effect of in order to confirm powdered anthelmintic composition of the invention, respectively changes pest repellant, stimulation moderator, moisture
The merging of matching of retention agent and oil absorbent prepares powdered anthelmintic composition (embodiment 1~11, comparative example 1~3), using each
A composition simultaneously implements anthelminthic effect validation test (after initial stage, certain time warp) and sensory test (sticky feeling, moistening
Sense).
<The preparation of powdered anthelmintic composition>
First, it prepares pest repellant and stimulates the mixture of moderator, the mixture is made to be absorbed in oil absorbent.Then into
And water retention agent is added, by being fully mixed, obtain the powdered expelling parasite of embodiment 1~11 and comparative example 1~3
Composition.By the cooperation of pest repellant, stimulation moderator, water retention agent and oil absorbent in each Examples and Comparative Examples
(unit：Parts by weight) it is shown in table 1.
[table 1]
BAAPE：3- (N- normal-butyl-N- acetyl group) alanine ethyl ester
As pest repellant, Metadelphene, Icaridin or 3- (N- normal-butyl-N- acetyl group) alanine ethyl ester are used.
As stimulation moderator, 1,3-BDO is used.
As water retention agent, talcum is used.
As oil absorbent, silicic acid anhydride (trade name is used：CARPLEX (registered trademark) 80, Degussa Japan
Co. Ltd. system).
<Anthelminthic effect validation test>
The female insect 20 of Culex pipiens pallens is discharged to the chest for having sealable opening portion, will be applied respectively from opening portion
The arm of the cloth subject of the powdered anthelmintic composition of embodiment 1~11 and comparative example 1~3 (each 2g) is inserted into chest
It is interior, calculate the number (n for the Culex pipiens pallens for being attached to the arm of subject1).Moreover, as blank (blank), will be not coated with
The arm of the subject of the powdered anthelmintic composition of cloth is inserted into in the chest of condition, is similarly calculated and is attached to subject
An arm Culex pipiens pallens number (n0).Then the scattering ratio of Culex pipiens pallens is with (n0-n1)/n0[%] is calculated.Scattering ratio
Calculating be for (after just starting experiment) after just the beginning to use of powdered anthelmintic composition and from beginning to use after 4 hours
And carry out.The result of anthelminthic effect validation test is shown in table 2.
[table 2]
<Sensory test>
The powdered anthelmintic composition of embodiment 1~11 and comparative example 1~3 is coated on to the flesh of 10 people group members respectively
Skin, with its use feeling of 5 Phase Evaluations.Evaluation criteria is set as content as shown below, uses the evaluation of 10 people group members
The average value of point.
[sticky feeling]
5：It totally can not feel tacky.
4：Minimally feel tacky.
3：Slightly feel tacky.
2：Feel tacky.
1：Feel very much tacky.
[moist feeling]
5：Extremely there is moist feeling.
4：There is moist feeling.
3：Slightly there is moist feeling.
2：It is very little to have moist feeling.
1：Entirely without moist feeling.
The result of sensory test is shown in table 3.
[table 3]
By the result of anthelminthic effect validation test it is found that the powdered expelling parasite of embodiment J~11 and comparative example 1~3 is combined
Object has all assert sufficient repellent effect after just beginning to use.But if by 4 hours from beginning to use, embodiment 1~
11 powdered anthelmintic composition is hardly visible the reduction of repellent effect, for the powdered anthelmintic composition with duration,
And the powdered anthelmintic composition of comparative example 1~3 confirmed the reduction of repellent effect.It should be noted that the repellent effect
It reduces with time going by and becomes notable (omitted data).
About sensory test as a result, the powdered anthelmintic composition of embodiment 1~11 is seen on the whole, [sticky feeling] and
[moist feeling] is both high praise (i.e. sticky feeling is few, there is moist feeling), but the powdered expelling parasite of comparative example 1~3 is combined
Object can not take into account [sticky feeling] and [moist feeling], and evaluation point itself is also low.
Be clear that by above result, powdered anthelmintic composition of the invention because use feeling or duration are excellent, and
And do not include alcohol completely, even therefore as to stimulating the people of allergy, also easy-to-use insect repellent article is very useful.
Industrial availability
The powdered anthelmintic composition of the present invention can be used as human body or the insect repellent article of pet utilizes, other purposes
It can be in such as desinsection, mite killing, sterilization, antibacterial, deodorization and deodorization with utilizing on the way.
Claims (8)
1. a kind of powdered anthelmintic composition, contains：
To be selected from the group being made of Metadelphene, 3- (N- normal-butyl-N- acetyl group) alanine ethyl ester and Icaridin
At least one pest repellant as active ingredient；
Stimulation moderator using ethylene glycol series solvent as active ingredient；
Using talcum as the water retention agent of active ingredient；And
Oil absorbent using silicate compound as active ingredient,
The ratio between use level b of the use level a of the water retention agent and oil absorbent a: b with weight ratio meter be 3: 1~
20∶1。
2. powdered anthelmintic composition according to claim 1, wherein the ethylene glycol series solvent is 1,3-BDO.
3. powdered anthelmintic composition according to claim 1 or 2, wherein the talcum is measured according to JIS K5101
Apparent specific gravity is 0.4~0.6g/cc.
4. powdered anthelmintic composition described in any one of claim 1 to 3, wherein the average grain diameter of the talcum
It is 20 μm or more.
5. powdered anthelmintic composition according to any one of claims 1 to 4, wherein the silicate compound is nothing
Water silicon acid.
6. powdered anthelmintic composition according to any one of claims 1 to 5, wherein the ratio of the silicate compound
Surface area is 5~100m2/g。
7. according to powdered anthelmintic composition according to any one of claims 1 to 6, alcohol is not included.
8. a kind of manufacturing method of powdered anthelmintic composition, including：
It will be to be selected from the group being made of Metadelphene, 3- (N- normal-butyl-N- acetyl group) alanine ethyl ester and Icaridin
It is at least one as the pest repellant of active ingredient and using ethylene glycol series solvent as active ingredient stimulation moderator mix
Mixed processes；
The mixture obtained by the mixed processes is set to be absorbed in the oil absorbent using silicate compound as active ingredient
Absorption process；
Water retention agent using talcum as active ingredient is made an addition to, adding for the oil absorbent for absorbing process is completed
Process sequence；And
The agitating procedure that the mixture of each ingredient obtained by the addition process is stirred,
The additive amount a of the water retention agent in the addition process and the oil absorbent in the absorption process
The ratio between usage amount b a: b is with weight ratio meter for 3: 1~20: 1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015232906 | 2015-11-30 | ||
| JP2015-232906 | 2015-11-30 | ||
| PCT/JP2016/084905 WO2017094600A1 (en) | 2015-11-30 | 2016-11-25 | Powdery insect pest repellent composition and method for manufacturing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108347930A true CN108347930A (en) | 2018-07-31 |
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ID=58796654
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| Application Number | Title | Priority Date | Filing Date |
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| CN201680064957.XA Pending CN108347930A (en) | 2015-11-30 | 2016-11-25 | Powdered anthelmintic composition and its manufacturing method |
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| Country | Link |
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| JP (1) | JP6449484B2 (en) |
| CN (1) | CN108347930A (en) |
| TW (1) | TWI662895B (en) |
| WO (1) | WO2017094600A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114206111A (en) * | 2019-07-11 | 2022-03-18 | 桑德斯特罗曼有限责任公司 | Arthropod repelling composition |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111867379B (en) * | 2018-04-09 | 2021-12-24 | 大日本除虫菊株式会社 | Pest repellent and pest repellent product |
| WO2020137609A1 (en) * | 2018-12-26 | 2020-07-02 | 大日本除蟲菊株式会社 | Deodorization composition and deodorization method, and offensive odor-emitting pest control composition and offensive odor-emitting pest control method |
| DE102019112267A1 (en) | 2019-05-10 | 2020-11-12 | Henkel Ag & Co. Kgaa | Delayed release of an insect repellent compound |
| DE102020132182A1 (en) | 2020-12-03 | 2022-06-09 | Henkel Ag & Co. Kgaa | USE OF HYDRAZONES AS AN INSECT REPELLENT |
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| CN114206111A (en) * | 2019-07-11 | 2022-03-18 | 桑德斯特罗曼有限责任公司 | Arthropod repelling composition |
| CN114206111B (en) * | 2019-07-11 | 2024-04-02 | 桑德斯特罗曼有限责任公司 | Arthropod repellent composition |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017094600A1 (en) | 2017-06-08 |
| TWI662895B (en) | 2019-06-21 |
| JP6449484B2 (en) | 2019-01-09 |
| JPWO2017094600A1 (en) | 2018-06-21 |
| TW201720301A (en) | 2017-06-16 |
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