CN108339013A - A kind of taste masking spray and preparation method thereof - Google Patents

Abstract

The invention belongs to corrigent Development Techniques fields, and in particular to a kind of to have the taste masking spray and preparation method thereof covered Chinese medicine bitter taste, change the sense of taste.The spray is formulated by following mass percent：Miracle fruit 50%, arithoke 20%, sodium chloride 5%, hawthorn 5%, sodium benzoate 2%, vitamin E 3%, polysorbate 7%, distilled water 8%；Miracle fruit and arithoke pedestal petal carry out frozen dried according to the ratio, the raw material after freeze-drying are crushed processing, powder is made.Arithoke powder, which is dissolved in distilled water, to be boiled, the arithoke water cooling after boiling, and the auxiliary materials such as miracle fruit powder are added, is put into equipment and is uniformly dispersed, spraying is made, is filled into spray container.Spraying is sprayed in mouth before taking medicine, solves the problems, such as the hardship that takes traditional Chinese medicine, and does not influence the performance of herbal medicine efficacy.

Description

A kind of taste masking spray and preparation method thereof

Technical field

The invention belongs to corrigent Development Techniques fields, and in particular to a kind of to have cover Chinese medicine bitter taste, changing the sense of taste Taste masking spray and preparation method thereof.

Background technology

Nowadays Chinese medicine uses in the world, and prodigious achievement, sample are achieved in terms for the treatment of chronic disease It is part-time, eradicate persistent ailment.However though herbal function is good, taste is very bitter, and the course for the treatment of is also grown, and causes patient compliance poor, some patients It is final to refuse Chinese medicine treatment even because Chinese medicine taste is difficult to swallow.Therefore, Chinese medicine bitter taste how is removed to study at present Hot spot.

The conventional medicament that Chinese medicine treats disease as China is with a long history, significant in efficacy, 2015 editions according to statistics《Chinese Pharmacopoeia》It receives Bitter taste medicinal material accounts for 60% or more in the 618 kinds of medicinal materials and medicine materical crude slice of record, and chemical composition of Chinese materia medica is complicated, and a kind of bitter taste medicinal material usually contains Include mainly following three classes there are many bitter substance one of the most common：1. alkaloids, as mainly contained in Cortex Phellodendri and the coptis Jamaicin, the strychnine in vomiting nut, the liensinine in lotus nut, the ephedrine etc. in Chinese ephedra.2. terpene, also known as bitter taste Element generally has bitter taste, such as the rough gentian in rough gentian more because that can form the structure of chelate containing lactone, aldolactol, glycosyl etc. The oleanolic acid and ursolic acid in andrographolide, loguat leaf in bitter glycosides, Herba Andrographitis.3. glycoside refers mainly to flavonoids Close scutelloside, the Quercetin in ginkgo leaf, the cyanidenon in wild chrysanthemum etc. in object, such as radix scutellariae.Although these ingredient tastes Hardship, but usually with medicinal material the effect of it is directly related, and its bitter be influence patient medication compliance an important factor for.

Also have one while the auxiliary materials such as Icing Sugar, dextrin are often added in drug production process at present as filler binder Fixed flavored action, but it is ineffective, therefore better masking methods are found into research hotspot for the bitter substance in Chinese medicine. Somebody directly eats a candy when drinking Chinese medicine or after drinking Chinese medicine, to alleviate the pain that Chinese medicine bitter taste is brought, but actually simultaneously There is no great effect, it is also possible to influence the performance of herbal medicine efficacy.

Invention content

There is cover Chinese medicine bitter taste, the taste masking spray for changing the sense of taste and its preparation the purpose of the present invention is to provide a kind of Method.

For achieving the above object, the present invention uses following technical scheme：

A kind of taste masking spray, the spray are formulated by following mass percent：

Miracle fruit：50%,

Arithoke：20%,

Sodium chloride：5%,

Hawthorn：5%,

Sodium benzoate：2%,

Vitamin E：3%,

Polysorbate：7%,

Distilled water：8%.

The preparation method of above-mentioned taste masking spray, includes the following steps：

（1）After miracle fruit, hawthorn, arithoke pedestal petal are carried out frozen dried according to the ratio, powder is made in crushing；

（2）By step（1）Obtained arithoke powder, which is dissolved in distilled water, to be boiled, and the arithoke water cooling obtained after boiling is spare；

（3）By step（1）Other auxiliary materials in obtained miracle fruit powder, hawthorn fruit and proportioning are added to step（2）In In arithoke water, be put into equipment and be uniformly dispersed, spraying is made, be filled into spray container to get.

Before taking medicine by above-mentioned spray in mouth, solve the problems, such as that taste is difficult to receive during taking traditional Chinese medicine, and not Influence the performance of herbal medicine efficacy.

Miracle fruit contains a kind of special spoiled protease, can be with although can not veritably change taste of food Change the sense of taste of people.After edible miracle fruit, protease therein can be distributed on the taste buds cell film of tongue, in neutral pH When under environment, sweet taste receives albumen and will not be combined by by position with sweet taste, therefore On Miraculin does not have sweet taste.In other edible tastes After the food in road, the membrane structure on tongue changes, and sweet taste, which receives albumen, can be incorporated on sweet taste acceptor site, just feel Sweet taste.

With bud for the cultigen of food, the perennial dicotyledonous draft vegetable plant of perennial root in arithoke category composite family cynara scolymus category.Battalion It is high to support value, there is the title of " emperors of vegetables ".It contains a kind of acidic materials being referred to as anghirol, and this substance can have Effect hinders sweet taste.After first eating the food for having added anghirol, then a kind of food without globe artichoke is eaten, is eaten compared to former Object, people just will produce a kind of feeling of comparison, hence it is evident that it is more preferable to experience the latter's taste.

Sodium chloride is to promote the performance of sweet taste from the negative using the opposition taste with sweet taste, and people is allowed fully to experience sweet taste. For example add a little salt in not yet full ripe, slightly bitter taste fruit, people can be allowed to feel more sweet tea.Because sweet taste is than bitter Taste is more prone to that people is allowed to capture, so adding a little salt in food, people can be allowed to enjoy to a greater degree sweet in food Sweet tea.

Hawthorn is sour sweet and contain lipolytic enzyme containing a variety of organic acids such as crataegolic acid, enters to enhance after stomach the effect of enzyme, promotes to disappear Change, cholesterol is contributed to convert.And miracle fruit acid things effect this kind of to hawthorn is notable, can significantly make one to produce things Raw sweet feeling.

Compared with prior art, the beneficial effects of the invention are as follows：Raw material miracle fruit, hawthorn and arithoke of the present invention nutrition at Can be complementary on point, moreover, miracle fruit, arithoke and the compound mouthfeel that can improve hawthorn of hawthorn, it is not necessary that glucide is added just Taste can be made to become sweet and sour taste, improve appetite, have effects that improve appetite, improve immunity；Contain one kind in miracle fruit Spoiled protease is also known as On Miraculin, although it cannot really change taste of food, can change the sense of taste of people, mysterious Fruit element enters oral cavity, can be distributed on the taste buds cell film of tongue, it can close tongue and be responsible for sour, puckery, bitter taste taste bud, open It is responsible for the taste bud of sweet taste.Therefore, miracle fruit can cause people's gustatory nerve tip to change the reaction of taste of food, can be with Tart flavour, bitter taste are become into sweet taste.Raw material of the present invention is that pure natural plant medicines are easy to get safely without any toxicity and side effects, preparation method It is simple to operation.Arithoke is easily aoxidized after processing, is prolonged the service life after antioxidant is added.The present invention is effectively improved Chinese medicine The problem of taste suffering is to swallow, and the performance of herbal medicine efficacy is not influenced, it is suitable for various people, children, old man, pregnant woman are all It can be used.

Specific implementation mode

Further detailed description is done to the present invention with reference to embodiment, embodiments of the present invention are not limited thereto.

Embodiment 1

A kind of taste masking spray is made per 100g sprays of following raw material：Miracle fruit 50g, 20 g of arithoke, 5 g of sodium chloride, 5 g of hawthorn, sodium benzoate（Cosolvent）2 g, vitamin E（Antioxidant）3 g, polysorbate（Preservative）7 g, distilled water 8 g。

Miracle fruit, hawthorn, arithoke pedestal petal are subjected to frozen dried by said ratio, the miracle fruit after freeze-drying, mountain Short, bristly hair or beard, arithoke crush processing and powder are made；Arithoke powder, which is dissolved in distilled water, to be boiled, the arithoke water cooling after boiling, then Other auxiliary materials in miracle fruit powder and hawthorn fruit and mentioned proportioning are added, is put into equipment and is uniformly dispersed, spray is made Mist is filled into spray container.

Before taking medicine by spray in mouth.

Embodiment 2

Spray of the present invention covers bitter taste experiment：

It is tested medicine preparation：Each 10 grams of radix scutellariae, Cortex Phellodendri, the coptis, rough gentian, Herba Andrographitis are taken, 1000 milliliters of distilled water are separately added into, is soaked Bubble extracts 2 times after 24 hours, and merging filtrate is cooled to room temperature, is centrifuged after staying overnight, and sterilizes after taking supernatant to dilute 5 times, spare.

The determination of bitter degree opinion rating and scoring range at different levels：According to document Chinese experimental pharmacology of traditional Chinese medical formulae magazine：《The mouth method of tasting is commented The research of valence traditional Chinese herbal decoction bitter taste》（2011,17(23):11-13）, and the characteristics of combination Chinese medicine, determine the bitter degree rank of Chinese medicine It is 1 ~ 5 grade.

20 volunteers are randomly selected, front and back contrast test is administered.It is gargled first using 25 milliliters of distilled water, every time Gargle 15s, accumulative to gargle 5 times；Interval advises volunteer to contain 25 milliliters of subject liquid in entrance after 30 minutes, timing 10 seconds, the phase Between oral cavity gargle action so that the bitter taste receptive field of the root of the tongue and tongue side can experience bitter taste of drug, and be apprised of the solution Bitter degree classification and specific bitter angle value, spue, gargle 5 times, each 15s；Volunteer's Intraoral Spray is advised to give after 30 minutes in interval 1 spray of embodiment advises volunteer to contain identical 25 milliliters subject liquid in entrance after giving, timing 10 seconds, during which oral cavity It gargles action, so that the bitter taste receptive field of the root of the tongue and tongue side can experience bitter taste of drug, and is apprised of the bitter degree point of the solution Grade and specific bitter angle value, spue.

Before and after 1 spray of embodiment is given in comparison spraying, volunteer is to the testing evaluation of same bitter drug, evaluation implementation The taste masking effect of example 1.By table 1 as it can be seen that after giving 1 spray of embodiment, the bitter taste that can be substantially reduced subject drug is tested Point, 1 spray of embodiment has preferable taste masking effect, can obviously cover the bitter taste of subject drug.

Table 1

Note：^*Compared with before administration, difference have statistical significance (P< 0.05)。

Claims (2)

1. a kind of taste masking spray, which is characterized in that the spray is formulated by following mass percent：

Miracle fruit：50%,

Arithoke：20%,

Sodium chloride：5%,

Hawthorn：5%,

Sodium benzoate：2%,

Vitamin E：3%,

Polysorbate：7%,

Distilled water：8%.

2. the preparation method of taste masking spray described in claim 1, which is characterized in that include the following steps：

（1）After miracle fruit and arithoke pedestal petal are carried out frozen dried according to the ratio, powder is made in crushing；

（2）By step（1）Obtained arithoke powder, which is dissolved in distilled water, to be boiled, and the arithoke water cooling obtained after boiling is spare；

（3）By step（1）Obtained miracle fruit powder and the hawthorn in proportioning and other auxiliary materials are added to step（2）In arithoke In water, be put into equipment and be uniformly dispersed, spraying is made, be filled into spray container to get.