CN1083360A - Runshu eye drops and preparation method thereof - Google Patents
Runshu eye drops and preparation method thereof Download PDFInfo
- Publication number
- CN1083360A CN1083360A CN 93111305 CN93111305A CN1083360A CN 1083360 A CN1083360 A CN 1083360A CN 93111305 CN93111305 CN 93111305 CN 93111305 A CN93111305 A CN 93111305A CN 1083360 A CN1083360 A CN 1083360A
- Authority
- CN
- China
- Prior art keywords
- gram
- chloromycetin
- hyaluronic acid
- borax
- acid sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention belongs to field of pharmaceutical technology, is a kind of main treatment xerophthalmia, also can treat the eye drop of various oculopathy such as trachoma, conjunctivitis, corneal ulcer and eyeball inflammation.The prescription and the consumption of eye drop of the present invention are: in the 100ml eye drop, wherein chloromycetin 0.25 gram, boric acid 1.4～1.9 grams, Borax 0.03～0.3 restrain, hyaluronic acid sodium 0.1～0.5 gram, and phenylmercuric acetate 0.002～0.005 gram, all the other are distilled water.Eye drop treatment xerophthalmia effect of the present invention is remarkable, and various oculopathy such as treatment trachoma, conjunctivitis, corneal ulcer, eyeball inflammation are all better than chloromycetin eyedrops and various eye ointment curative effect.
Description
The invention belongs to field of pharmaceutical technology, is a kind of main treatment xerophthalmia, also can treat trachoma, the eye drop of various oculopathy such as conjunctivitis, corneal ulcer and eyeball inflammation.
Xerophthalmia is a kind of climacteric patient and common complaint among the elderly.Because xerophthalmia is the disease that causes because of tear, mucin secretion deficiency, so Most patients easily causes various oculopathy such as xerophthalmia cornea and conjunctivitis, brings many miseries to the patient.At present, China's medical market does not have the medicine of specially controlling xerophthalmia as yet, generally only adopts oral medicines such as vitamin A, vitamin D to nurse one's health, and does not finally still reach the effect of treatment.In addition, treat the liquid medicine of oculopathy at present, because it rests in the eyelid between can not be more often, so therapeutic effect is not good enough.Though eye ointment can rest in the eyelid for a long time, higher because of its viscosity, block sight line, thereby be only limited to use in bed, so general persons suffering from ocular disorders all needs eye water, eye ointment to use respectively, a kind of oculopathy of ruling together is brought inconvenience to the patient.
The objective of the invention is: a kind of main treatment xerophthalmia is provided, and can treat the eye drop of various oculopathy such as trachoma, conjunctivitis, corneal ulcer and eyeball inflammation, it is had has extremely strong moistening and lubrication to eye, can improve the nutrition and the advantage such as anti-inflammatory treatment of tissue; And provide the preparation method of a kind of eye drop.
The prescription of eye drop of the present invention is: chloromycetin, boric acid, Borax, hyaluronic acid sodium, phenylmercuric acetate and distilled water.Wherein phenylmercuric acetate can substitute with phenylmercuric nitrate or Sodium Mercurothiolate.
The prescription and the amount ranges of eye drop of the present invention are: in the 100ml eye drop, wherein chloromycetin 0.25 restrains, boric acid 1.4～1.9 grams, and Borax 0.03～0.3 gram, hyaluronic acid sodium 0.1～0.5 gram, phenylmercuric acetate 0.002～0.005 gram, all the other are distilled water.
Eye drop prescription of the present invention and consumption are: in the 100ml eye drop, and chloromycetin 0.25 gram, boric acid 1.5 grams, Borax 0.1 gram, hyaluronic acid sodium 0.3 gram, phenylmercuric acetate 0.002 gram, all the other are distilled water.
Eye drop prescription of the present invention and consumption are: in the 100ml eye drop, and chloromycetin 0.25 gram, boric acid 1.7 grams, Borax 0.2 gram, hyaluronic acid sodium 0.5 gram, phenylmercuric nitrate 0.01 gram, all the other are distilled water.
The manufacture method of eye drop of the present invention, by eye drop prescription of the present invention and consumption, hyaluronic acid sodium is immersed in the water, make its dissolving back standby, after getting boric acid and Borax heating for dissolving, add chloromycetin and phenylmercuric nitrate, when being chilled to 0～40 ℃ after the dissolving, add hyaluronic acid sodium solution, add distilled water then to 100ml, with the microporous filter membrane aseptic filtration of 0.2～0.6um, seal after the packing, promptly obtain eye drop of the present invention.
Since adopted hyaluronic acid sodium in the eye drop of the present invention, thus eye is had extremely strong moistening and lubrication, and can improve the nutrition of tissue, the medicinal liquid adhesion is strong, the surface activity height alleviates the stimulation of chloromycetin to eye, because eye drop of the present invention has certain viscosity, do not block sight line, but the long period rests in the eyelid during use, and flows into nasal cavity not really soon, also is difficult for overflowing eyelid, area and time that medicinal liquid contacts with eye have been increased, so its raising evident in efficacy.Therefore, through clinic trial, treatment xerophthalmia effect is remarkable, and various oculopathy such as treatment trachoma, conjunctivitis, corneal ulcer, eyeball inflammation are all better than chloromycetin eyedrops and various eye ointment curative effect.The patient only need use this eye drop, does not need a hydrophthalmia cream to use respectively, just can reach good equally therapeutic effect.
The embodiment of the invention:
The value of prescription mesoboric acid and Borax must be satisfied with eye near etc. ooze, the requirement of PH6-7.
1, eye drop of the present invention, in 100ml, extracting chloromycetin 0.25 gram, boric acid 1.4 grams, Borax 0.3 gram, hyaluronic acid sodium 0.1 gram, phenylmercuric nitrate 0.005 gram, all the other are distilled water, produce according to the method for the invention.
2, eye drop prescription of the present invention: in 100ml, extracting chloromycetin 0.25 gram, boric acid 1.9 grams, Borax 0.03 gram, hyaluronic acid sodium 0.5 gram, phenylmercuric acetate 0.002 gram, all the other are distilled water, produce according to the method for the invention.
3, eye drop prescription of the present invention: in 100ml, extracting chloromycetin 0.25 gram, boric acid 1.7 grams, Borax 0.15 gram, hyaluronic acid sodium 0.3 gram, Sodium Mercurothiolate 0.01 gram, all the other are distilled water, produce according to the method for the invention.
4, eye drop of the present invention: in 100ml: extracting chloromycetin 0.25 gram, boric acid 1.8 grams, Borax 0.13 gram, hyaluronic acid sodium 0.3 gram, phenylmercuric acetate 0.005 gram, all the other are distilled water, produce by the method for the invention.
5, eye drop of the present invention, in 100ml, extracting chloromycetin 0.25 gram, boric acid 1.5 grams, Borax 0.19 gram, hyaluronic acid sodium 0.2 gram, phenylmercuric nitrate 0.005 gram, all the other are distilled water, produce by the method for the invention.
6, the preparation method of eye drop of the present invention: produce the 100ml eye drop, 0.5 gram hyaluronic acid sodium is immersed in the water, make its dissolving standby, get 1.7 gram boric acid, 0.2 gram Borax, after the heating for dissolving, add when being chilled to 30 ℃ after 0.25 gram chloromycetin and 0.002 gram vinegar benzene hydrargyrum dissolve, add hyaluronic acid sodium solution, add distilled water behind the mix homogeneously, with the microporous filter membrane aseptic filtration of 0.2um, seal after the packing, promptly obtain eye drop of the present invention.
7, eye drop of the present invention: in 100ml eye liquid: extracting chloromycetin 0.25 gram, boric acid 1.67 grams, Borax 0.15 gram, hyaluronic acid sodium 0.2 gram, phenylmercuric acetate 0.002 gram, all the other are distilled water, produce by the method for the invention.
Claims (7)
1, Runshu eye drops contains chloromycetin in its prescription, it is characterized in that: also have boric acid, Borax, hyaluronic acid sodium, phenylmercuric acetate and distilled water in the eye drop prescription.
2, according to claim, described Runshu eye drops is characterized in that chloromycetin 0.25 gram, boric acid 1.4～1.9 grams, and Borax 0.03～0.3 gram, hyaluronic acid sodium 0.1～0.5 gram, phenylmercuric acetate 0.002～0.005 gram, all the other are distilled water.
3, according to the described Runshu eye drops of claim 1, it is characterized in that: chloromycetin 0.25 gram, boric acid 1.6 grams, Borax 0.2 gram, hyaluronic acid sodium 0.3 gram, phenylmercuric acetate 0.002 gram, all the other are distilled water.
4, according to the described Runshu eye drops of claim 2, it is characterized in that: chloromycetin 0.25 gram, boric acid 1.7 grams, Borax 0.1 gram, hyaluronic acid sodium 0.5 gram, phenylmercuric acetate 0.002 gram, all the other are distilled water.
5, according to the described Runshu eye drops of claim 2, it is characterized in that: chloromycetin 0.25 gram, boric acid 1.5 grams, Borax 0.19 gram, hyaluronic acid sodium 0.2 gram, phenylmercuric acetate 0.005 gram, all the other are distilled water.
6, Runshu eye drops manufacture method, it is characterized in that: produce the 100ml eye drop hyaluronic acid sodium is immersed in the water, make its dissolving back standby, after getting boric acid and Borax heating for dissolving, add chloromycetin and phenylmercuric nitrate, when being chilled to 0～40 ℃ after the dissolving, add hyaluronic acid sodium solution, add distilled water then to 100ml,, seal after the packing with the microporous filter membrane aseptic filtration of 0.2～0.6um.
7, according to the described Runshu eye drops manufacture method of claim 6, it is characterized in that: produce the 100ml eye drop, 0.5 gram hyaluronic acid sodium is immersed in the water, make its dissolving standby, get 1.9 gram boric acid, 0.2 gram Borax, when being chilled to 30 ℃ after adding 0.25 gram chloromycetin and the 0.002 gram phenylmercuric acetate heating for dissolving after the heating for dissolving, add hyaluronic acid sodium solution, add distilled water behind the mix homogeneously, with the microporous filter membrane aseptic filtration of 0.2um, seal after the packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111305A CN1045382C (en) | 1993-06-17 | 1993-06-17 | Runshu eye drops and making method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111305A CN1045382C (en) | 1993-06-17 | 1993-06-17 | Runshu eye drops and making method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1083360A true CN1083360A (en) | 1994-03-09 |
| CN1045382C CN1045382C (en) | 1999-10-06 |
Family
ID=4989103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93111305A Expired - Lifetime CN1045382C (en) | 1993-06-17 | 1993-06-17 | Runshu eye drops and making method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1045382C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063633C (en) * | 1994-04-06 | 2001-03-28 | 王玉琪 | Fog-removing medicine |
| CN100369604C (en) * | 2006-04-30 | 2008-02-20 | 段玉新 | Drop pill type eye drip fluid of chloramphenicol, and preparation method |
| CN103550145A (en) * | 2013-10-29 | 2014-02-05 | 沈阳神龙药业有限公司 | Chloramphenicol eye drops and preparation method thereof |
| CN104474009A (en) * | 2014-11-26 | 2015-04-01 | 杭州光祺力实业有限公司 | Eye cleaning liquid and preparation method thereof |
| CN110585126A (en) * | 2019-11-05 | 2019-12-20 | 河北医科大学 | Eye drop preparation and preparation method and application thereof |
-
1993
- 1993-06-17 CN CN93111305A patent/CN1045382C/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063633C (en) * | 1994-04-06 | 2001-03-28 | 王玉琪 | Fog-removing medicine |
| CN100369604C (en) * | 2006-04-30 | 2008-02-20 | 段玉新 | Drop pill type eye drip fluid of chloramphenicol, and preparation method |
| CN103550145A (en) * | 2013-10-29 | 2014-02-05 | 沈阳神龙药业有限公司 | Chloramphenicol eye drops and preparation method thereof |
| CN104474009A (en) * | 2014-11-26 | 2015-04-01 | 杭州光祺力实业有限公司 | Eye cleaning liquid and preparation method thereof |
| CN110585126A (en) * | 2019-11-05 | 2019-12-20 | 河北医科大学 | Eye drop preparation and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1045382C (en) | 1999-10-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109419770A (en) | A kind of mescenchymal stem cell excretion body eye drops and its preparation method and application | |
| CN1183302A (en) | Eye drops contg. sodium hyaluronate and preparing method thereof | |
| CN1083360A (en) | Runshu eye drops and preparation method thereof | |
| CN1011118B (en) | Eyedrops for cataract and their preparation | |
| JPH0651638B2 (en) | Eye drops for corneal epithelial wound treatment | |
| CN104857287B (en) | Traditional Chinese medicine eye drops for treating xerophthalmia and preparation method thereof | |
| CN102525889A (en) | Ornidazole ophthalmic gel and preparation method and application thereof | |
| CN105902686A (en) | In-situ gel eyewash containing nano-carbon crystals and preparation method thereof | |
| CN103877288A (en) | Biomedical film made of chitosan for nasopharyngitis and preparation method thereof | |
| AU2013101038A4 (en) | A dietary supplement to treat dry eyes | |
| CN102552734A (en) | Gargle for treating dental ulcer | |
| King et al. | Do topical antibiotics help corneal epithelial trauma? | |
| CN1311842C (en) | Medicine for treating chronic conjunctivitis | |
| CN1129127A (en) | Liquid good for eyesight | |
| CN103550357B (en) | A kind of control muscae volitantes collyrium and its production and use | |
| CN112107623B (en) | Traditional Chinese medicine composition for improving meibomian gland function | |
| CN1126076A (en) | Pearl liquid for improving eyesight | |
| CN100540049C (en) | Fibre connexin active tears and production method thereof | |
| CN102836178A (en) | Externally-applied medicine for treating otitis media | |
| CN100496502C (en) | Preparation method of capsule drop for protecting eye | |
| Gao et al. | Integrated Chinese and Western Medicine for the Treatment of Acne Associated Blepharokeratoconjunctivitis Case 1 | |
| CN2288718Y (en) | Medicine supply cleaning therapentic equipment for ophthalmopathy | |
| CN1846708A (en) | Prepn process of glucose eye lotion | |
| Moroney | Dry eyes | |
| CN109078159A (en) | It is a kind of for treating the cell nutritious element and production method of dry eyes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20130617 Granted publication date: 19991006 |