CN108324661A - Antibacterial anti-inflammatory based on beta-cyclodextrin, except implication mouthwash and preparation method thereof - Google Patents
Antibacterial anti-inflammatory based on beta-cyclodextrin, except implication mouthwash and preparation method thereof Download PDFInfo
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- CN108324661A CN108324661A CN201810141515.1A CN201810141515A CN108324661A CN 108324661 A CN108324661 A CN 108324661A CN 201810141515 A CN201810141515 A CN 201810141515A CN 108324661 A CN108324661 A CN 108324661A
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- mouthwash
- cyclodextrin
- beta
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- 239000002324 mouth wash Substances 0.000 title claims abstract description 87
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 87
- 229920000858 Cyclodextrin Polymers 0.000 title claims abstract description 67
- 239000001116 FEMA 4028 Substances 0.000 title claims abstract description 67
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 title claims abstract description 67
- 235000011175 beta-cyclodextrine Nutrition 0.000 title claims abstract description 67
- 229960004853 betadex Drugs 0.000 title claims abstract description 67
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 230000000844 anti-bacterial effect Effects 0.000 title abstract description 11
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract description 10
- 239000000243 solution Substances 0.000 claims abstract description 58
- 239000000706 filtrate Substances 0.000 claims abstract description 55
- 239000000419 plant extract Substances 0.000 claims abstract description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 39
- 241000241413 Propolis Species 0.000 claims abstract description 33
- 229940069949 propolis Drugs 0.000 claims abstract description 33
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 27
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229940041616 menthol Drugs 0.000 claims abstract description 27
- 239000002994 raw material Substances 0.000 claims abstract description 27
- 239000008367 deionised water Substances 0.000 claims abstract description 26
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 26
- 239000002904 solvent Substances 0.000 claims abstract description 21
- 239000000080 wetting agent Substances 0.000 claims abstract description 20
- 241000220317 Rosa Species 0.000 claims description 36
- 241000219784 Sophora Species 0.000 claims description 36
- 241000233855 Orchidaceae Species 0.000 claims description 35
- 241000628997 Flos Species 0.000 claims description 31
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 31
- 241000196324 Embryophyta Species 0.000 claims description 29
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 24
- 241000207840 Jasminum Species 0.000 claims description 22
- 235000010254 Jasminum officinale Nutrition 0.000 claims description 22
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 22
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 22
- 239000000811 xylitol Substances 0.000 claims description 22
- 235000010447 xylitol Nutrition 0.000 claims description 22
- 229960002675 xylitol Drugs 0.000 claims description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 20
- 239000001509 sodium citrate Substances 0.000 claims description 16
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 16
- 244000035851 Chrysanthemum leucanthemum Species 0.000 claims description 15
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 15
- 244000242564 Osmanthus fragrans Species 0.000 claims description 14
- 235000019083 Osmanthus fragrans Nutrition 0.000 claims description 14
- 239000000047 product Substances 0.000 claims description 14
- 238000001256 steam distillation Methods 0.000 claims description 14
- 239000007864 aqueous solution Substances 0.000 claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 238000000874 microwave-assisted extraction Methods 0.000 claims description 12
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- 210000000214 mouth Anatomy 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 8
- 241000894006 Bacteria Species 0.000 claims description 6
- 241000723353 Chrysanthemum Species 0.000 claims description 4
- 235000007516 Chrysanthemum Nutrition 0.000 claims description 4
- 230000002159 abnormal effect Effects 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000019634 flavors Nutrition 0.000 claims description 4
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 3
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 claims description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 3
- 239000001630 malic acid Substances 0.000 claims description 3
- 235000011090 malic acid Nutrition 0.000 claims description 3
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 3
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 3
- 229940113124 polysorbate 60 Drugs 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- 208000007117 Oral Ulcer Diseases 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 230000000675 anti-caries Effects 0.000 claims description 2
- 208000002399 aphthous stomatitis Diseases 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 9
- 238000010521 absorption reaction Methods 0.000 abstract description 5
- 230000004936 stimulating effect Effects 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 5
- 230000002421 anti-septic effect Effects 0.000 abstract description 4
- 230000000767 anti-ulcer Effects 0.000 abstract description 3
- 230000001151 other effect Effects 0.000 abstract description 3
- 230000000052 comparative effect Effects 0.000 description 17
- 238000000034 method Methods 0.000 description 17
- 206010006326 Breath odour Diseases 0.000 description 12
- 208000032139 Halitosis Diseases 0.000 description 12
- 230000000694 effects Effects 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 7
- 238000012360 testing method Methods 0.000 description 6
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 210000002200 mouth mucosa Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 2
- 101100248253 Arabidopsis thaliana RH40 gene Proteins 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 241000607598 Vibrio Species 0.000 description 2
- 230000000711 cancerogenic effect Effects 0.000 description 2
- 231100000315 carcinogenic Toxicity 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 208000010266 Aggressive Periodontitis Diseases 0.000 description 1
- 241000283153 Cetacea Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 208000012895 Gastric disease Diseases 0.000 description 1
- 206010020674 Hypermetabolism Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010021703 Indifference Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- 206010044029 Tooth deposit Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
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- 230000007613 environmental effect Effects 0.000 description 1
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- 239000000284 extract Substances 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
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- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 201000006727 periodontosis Diseases 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000012113 quantitative test Methods 0.000 description 1
- 238000002310 reflectometry Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cosmetics (AREA)
Abstract
The antibacterial anti-inflammatory that the present invention relates to a kind of based on beta cyclodextrin, except implication mouthwash and preparation method thereof.Mouthwash raw material includes：0.01~2.0 part of propolis, 0.5~5.0 part of solubilizer, 0.1~2.0 part of beta cyclodextrin, 10~30 parts of wetting agent, 0.05~0.5 part of acidity regulator, 0.01~0.5 part of menthol, 1.0~20 parts of plant extracts and deionized water.Preparation method：Propolis, solubilizer, wetting agent and menthol are mixed, the first solution is obtained；Surplus stock component is mixed, the second solution is obtained；Second solution is added in the first solution, deionized water is added, collects filtrate later, obtains mouthwash.Mouthwash of the present invention is based on beta cyclodextrin absorption principle, raw material selection and proportioning science, containing alcohol and chemical antiseptic, not safe and non-stimulating, it with excellent antibacterial, anti-inflammatory, antiulcer, removal implication and refreshes the mind and other effects, disclosure satisfy that the needs of various people.
Description
Technical field
The present invention relates to oral health technical fields, and in particular to a kind of antibacterial anti-inflammatory based on beta-cyclodextrin removes implication
Mouthwash and preparation method thereof.
Background technology
With the development of society, the social chance of people is more and more, when talking face to face, pure and fresh implication is kept,
It is the premise that sound impression is left to people.Although it is the preferably most direct method of fresh breath to brush teeth, it is limited to condition, we are but
There cannot be the chance brushed teeth whenever and wherever possible；Therefore, how the moment keeps pure and fresh implication, becomes in the current social activity of people
A great problem.The product of fresh breath effect can be played on the market based on chewing gum at present；However, the danger to chew gum
Evil is obvious：1, it ptyalizes, oral cavity is allowed to be in hypermetabolism state, the unnecessary saliva pair of hypersecretion for a long time
Body is done harm rather than good.2, long-time chew gum can secrete a large amount of hydrochloric acid in gastric juice to reflectivity, can also digestive ferment be made to increase, be easy
Cause the symptoms such as nausea, sour regurgitation, especially patients with gastric disease symptom can be more obvious.3, open air chew gum can allow stomach in fill into very much
Air causes abdominal distension.4, movement is often largely carried out by chew, masseter can be made more flourishing, face is caused to become larger, this is to some
For female consumer, cannot especially it receive.
In addition, people are sometimes due to some special reason (such as bodily injury, handicapped, wearing facing or pregnancy periods
It is front and back), the behavior of brushing teeth can not be completed, the bacterium in oral cavity is easy to cause the common orals disease such as decayed tooth and periodontosis.Therefore, one
The suitable mouthwash of money is the primary selection that people carry out oral cleaning.
The mouthwash of United States food and drag administration's certification has two classes：Mouthwash containing essential oil and containing chlorohexidene.Wherein,
Essential oil class mouthwash alcohol content is higher, the carcinogenic substances such as nicotine can be caused to be more easy to penetrate into oral cavity wall, and the metabolism of alcohol is carcinogenic
Product acetaldehyde is easy to accumulate in the oral cavity by the process of gargling；And mouthwash containing chlorohexidene the shortcomings that being used for a long time is easily to cause
Dental calculus is formed, facing coloring and the sense of taste change.
In the mouthwash that the country is currently known, chemically synthesized chlorhexidine gluconate CHX or chlorination whale are contained mostly
The ingredients such as wax pyridine CPC and alcohol, such water constituent of gargling can cause to stimulate to the oral mucosa of common people, can also make tooth
Turn yellow, influences appearance；In addition, white lesions of the alcohol in addition to be easy to causeing oral mucosa, can also influence alcohol screen test concentration, no
Suitable for the oral disinfecting after having a dinner party out.
Based on this, providing one kind not stimulating oral mucosa, and can reach good oral bacteriostasis effect, while being suitable as out
The mouthwash for removing removing abnormal flavor in oral cavity after having a dinner party outside is particularly important.
Invention content
For the defects in the prior art, the present invention is intended to provide a kind of antibacterial anti-inflammatory based on beta-cyclodextrin, removing implication
Mouthwash and preparation method thereof.Mouthwash provided by the invention, the absorption principle based on beta-cyclodextrin, raw material selection and proportioning section
It learns, containing alcohol and chemical antiseptic, not safe and non-stimulating, not only has excellent antibacterial, anti-inflammatory, antiulcer, removal implication and carries
Refreshing restoring consciouness and other effects, and the bad smell of propolis can be effectively covered, it disclosure satisfy that the needs of various people.
To achieve the above object, present invention offer following technical scheme is：
In a first aspect, the present invention provides a kind of mouthwash based on beta-cyclodextrin, in every 100 parts by weight mouthwash, including
Following raw material components：0.01~2.0 parts by weight of propolis, 0.5~5.0 parts by weight of solubilizer, 0.1~2.0 parts by weight of beta-cyclodextrin,
10~30 parts by weight of wetting agent, 0.05~0.5 parts by weight of acidity regulator, 0.01~0.5 parts by weight of menthol, plant extracts
1.0~20 parts by weight, surplus are deionized water.
Preferably, solubilizer includes：One kind or more in Crodaret RH40, polysorbate60 and span 40
Kind；Wetting agent includes：Glycerine and/or sorbierite；Acidity regulator includes：One kind in citric acid, sodium citrate and malic acid
Or it is a variety of.
Preferably, raw material components further include 0.05~0.5 parts by weight of xylitol.
Preferably, the plant material in plant extracts include orchid, jasmine, FLOS CHRYSANTHEMI ALBA from Haizhou of China, wild chrysanthemum, sophora flower, rose or
It is one or more in sweet osmanthus；Wherein, the raw material components of plant by weight, including：1~2 parts by weight of orchid, jasmine 3~5
Parts by weight, 1~3 parts by weight of FLOS CHRYSANTHEMI ALBA from Haizhou of China, 2~5 parts by weight of wild chrysanthemum, 2~3 parts by weight of sophora flower, 1~2 parts by weight of rose and sweet osmanthus 3
~6 parts by weight.
Preferably, the raw material components of plant by weight, further include：1~3 parts by weight of product shell, amplexicaul jasmine leaf 0.1~0.5
0.5~1.5 parts by weight of parts by weight and rhizoma anemarrhenae.
Preferably, the preparation method of plant extracts includes the following steps：S101：It is crushed after each plant is cleaned, dried；
S102：It is extracted using steam distillation after FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid after crushing is mixed, is filtered later
And collect the first filtrate；Surplus stock component after crushing is impregnated, Microwave Extraction is carried out later, filters and collect the second filter
Liquid；S103：First filtrate and the second filtrate are mixed, heating later is concentrated into the 1/2~2/3 of original volume.
Preferably, in S102：In steam distillation, the addition of water is FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid gross mass
5~8 times；In Microwave Extraction, microwave power be 1000MHz~1200MHz, temperature be 65~75 DEG C, the time be 100~
200min；Surplus stock component after crushing is used to the aqueous solution soaking of sodium citrate, and the quality of sodium citrate aqueous solution
Percentage concentration is 10~30%.
Second aspect, the present invention provide a kind of preparation method based on beta-cyclodextrin mouthwash, include the following steps：
S201：Propolis, solubilizer, wetting agent and menthol are uniformly mixed, the first solution is obtained；S202：By plant extracts, acidity
Conditioning agent, xylitol and beta-cyclodextrin are uniformly mixed, and obtain the second solution；S203：Second solution is added in the first solution
After mix, be added deionized water and be sufficiently stirred later, filter and collect filtrate, obtain mouthwash.
The third aspect, it is provided by the invention based on the mouthwash of beta-cyclodextrin prepare fresh breath, go removing abnormal flavor in oral cavity,
Application in inhibition oral bacteria, anti-oral ulcer and anti-caries tooth product and/or product additive.
The above technical solution of the present invention has the following advantages over the prior art：
(1) applicant has found by numerous studies：Mouthwash provided by the invention, the absorption principle based on beta-cyclodextrin,
Raw material selection and proportioning science, containing alcohol and chemical antiseptic, not safe and non-stimulating, not only has excellent antibacterial, anti-inflammatory, anti-burst
It ulcer, removal implication and refreshes the mind and other effects, and can effectively cover the bad smell of propolis, disclosure satisfy that various people's
It needs.
(2) solubility height, the beta-cyclodextrin with cavity structure is added to carry using propolis as main component in the present invention
Solubility of the high propolis in non-alcoholic solution, the bad smell for covering propolis, and then effectively absorption causes oral cavity in the oral cavity
The sulfide of peculiar smell；Be added with natural scents plant extracts, collaboration play antibacterial bacteriostatic, anti-inflammatory effect, make implication
It is pure and fresh, remove removing abnormal flavor in oral cavity；Solubilizer is added, improves the solubility of propolis and menthol, it is made utmostly to play effect.
(3) the preparation method process stabilizing of mouthwash provided by the invention, yield are high, high-quality, low energy consumption, raw material are wide
It is general, process is simple and cost-effective；Production can be completed using existing equipment, equipment requirement is reduced, to zero environmental.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obviously, or practice through the invention is recognized.
Specific implementation mode
The embodiment of technical solution of the present invention will be described in detail below.Following embodiment is only used for clearer
Illustrate technical scheme of the present invention, therefore be only used as example, and not intended to limit the protection scope of the present invention.
Experimental method in following embodiments is unless otherwise specified conventional method.Examination as used in the following examples
Material is tested, is to be commercially available from conventional reagent shop unless otherwise specified.Quantitative test in following embodiment, is all provided with
Three repeated experiments are set, data are the average value or mean+SD of three repeated experiments.
It is each that long-pending shell, amplexicaul jasmine leaf and rhizoma anemarrhenae as used in the following examples meet text of Chinese Pharmacopoeia (version in 2016)
Pertinent regulations under medicinal material item.Before feeding intake, by identification, ingredients material object is consistent with title, and quality complies with standard.
The present invention provides a kind of mouthwash based on beta-cyclodextrin, in every 100 parts by weight mouthwash, including following raw material groups
Point：0.01~2.0 parts by weight of propolis, 0.5~5.0 parts by weight of solubilizer, 0.1~2.0 parts by weight of beta-cyclodextrin, wetting agent 10~
30 parts by weight, 0.05~0.5 parts by weight of acidity regulator, 0.01~0.5 parts by weight of menthol, 1.0~20 weight of plant extracts
Part is measured, surplus is deionized water.Wherein, solubilizer includes：In Crodaret RH40, polysorbate60 and span 40
It is one or more；Wetting agent includes：Glycerine and/or sorbierite；Acidity regulator includes：Citric acid, sodium citrate and malic acid
In it is one or more；And raw material components preferably further include 0.05~0.5 parts by weight of xylitol.
In the further embodiment of the present invention, the plant material in plant extracts includes orchid, jasmine, Hang Bai
It is one or more in chrysanthemum, wild chrysanthemum, sophora flower, rose or sweet osmanthus；Wherein, the raw material components of plant by weight, including：It is blue
Spend 1~2 parts by weight, 3~5 parts by weight of jasmine, 1~3 parts by weight of FLOS CHRYSANTHEMI ALBA from Haizhou of China, 2~5 parts by weight of wild chrysanthemum, 2~3 parts by weight of sophora flower,
3~6 parts by weight of 1~2 parts by weight of rose and sweet osmanthus；The raw material components of plant by weight, preferably further include：Product 1~3 weight of shell
Measure part, 0.5~1.5 parts by weight of 0.1~0.5 parts by weight of amplexicaul jasmine leaf and rhizoma anemarrhenae.Wherein, the preparation method of plant extracts include with
Lower step：S101：It is crushed after each plant is cleaned, dried；S102：FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid after crushing is mixed
It is extracted afterwards using steam distillation, filter later and collects the first filtrate；Surplus stock component after crushing is impregnated,
Microwave Extraction is carried out later, filters and collects the second filtrate；S103：First filtrate and the second filtrate are mixed, heated later dense
It is reduced to the 1/2~2/3 of original volume.In S102：In steam distillation, the addition of water is FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid
5~8 times of gross mass；In Microwave Extraction, microwave power is 1000MHz~1200MHz, and temperature is 65~75 DEG C, the time 100
~200min；Surplus stock component after crushing is used to the aqueous solution soaking of sodium citrate, and the matter of sodium citrate aqueous solution
It is 10~30% to measure percentage concentration.
In addition, for the mouthwash based on beta-cyclodextrin of the present invention, applicant specially provides preparation method, including with
Lower step：
S201：Propolis, solubilizer, wetting agent and menthol are uniformly mixed, the first solution is obtained.
S202：Plant extracts, acidity regulator, xylitol and beta-cyclodextrin are uniformly mixed, the second solution is obtained.
S203：Mixing after second solution is added in the first solution is added deionized water and is sufficiently stirred, filters later
And filtrate is collected, obtain mouthwash.
It illustrates With reference to embodiment：
Embodiment one
The present embodiment provides a kind of mouthwash based on beta-cyclodextrin, in every 100 parts by weight mouthwash, including：Propolis
0.01 parts by weight, 5.0 parts by weight of Crodaret RH40,0.1 parts by weight of beta-cyclodextrin, 30 parts by weight of sorbierite,
0.05 parts by weight of acidity regulator sodium citrate, 0.5 parts by weight of menthol, 5 parts by weight of plant extracts, 0.5 weight of xylitol
Part, surplus is deionized water.Wherein, in plant extracts, the raw material components of plant by weight, including：2 weight of orchid
Part, 5 parts by weight of jasmine, 3 parts by weight of FLOS CHRYSANTHEMI ALBA from Haizhou of China, 2 parts by weight of wild chrysanthemum, 6 weight of 3 parts by weight of sophora flower, 1 parts by weight of rose and sweet osmanthus
Part；The preparation method of plant extracts includes the following steps：S101：It is crushed after each plant is cleaned, dried；S102：It will crush
FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid afterwards is extracted after mixing using steam distillation, and the addition of water is Hang Bai
Chrysanthemum, 5 times of sophora flower, rose and orchid gross mass, filter later and collect the first filtrate；Surplus stock component after crushing is adopted
The sodium citrate aqueous solution for being 30% with mass percentage concentration impregnates, and carries out Microwave Extraction later, filters and collect the second filtrate；
Microwave power is 1000MHz, and temperature is 75 DEG C, time 100min；S103：First filtrate and the second filtrate are mixed, later
Heating is concentrated into the 1/2 of original volume.
In addition, preparing the mouthwash based on beta-cyclodextrin for method provided by the invention, include the following steps：
S201：Propolis, solubilizer, wetting agent and menthol are uniformly mixed, the first solution is obtained.
S202：Plant extracts, acidity regulator, xylitol and beta-cyclodextrin are uniformly mixed, the second solution is obtained.
S203：Mixing after second solution is added in the first solution is added deionized water and is sufficiently stirred, filters later
And filtrate is collected, obtain mouthwash.
Embodiment two
The present embodiment provides a kind of mouthwash based on beta-cyclodextrin, in every 100 parts by weight mouthwash, including：Propolis 2.0
Parts by weight, 0.5 parts by weight of polysorbate60,2.0 parts by weight of beta-cyclodextrin, 10 parts by weight of glycerine, 0.5 weight of acidity regulator malic acid
Part, 0.01 parts by weight of menthol, 20 parts by weight of plant extracts, 0.05 parts by weight of xylitol are measured, surplus is deionized water.Its
In, in plant extracts, the raw material components of plant by weight, including：1 parts by weight of orchid, 3 parts by weight of jasmine, FLOS CHRYSANTHEMI ALBA from Haizhou of China 1
Parts by weight, 5 parts by weight of wild chrysanthemum, 3 parts by weight of 2 parts by weight of sophora flower, 2 parts by weight of rose and sweet osmanthus；The preparation side of plant extracts
Method includes the following steps：S101：It is crushed after each plant is cleaned, dried；S102：By after crushing FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and
It is extracted using steam distillation after orchid mixing, and the addition of water is FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid gross mass
8 times, filter later and collect the first filtrate；By the surplus stock component after crushing use mass percentage concentration for 10% lemon
Lemon acid sodium aqueous solution impregnates, and carries out Microwave Extraction later, filters and collect the second filtrate；Microwave power is 1200MHz, and temperature is
65, time 200min；S103：First filtrate and the second filtrate are mixed, heating later is concentrated into the 2/3 of original volume.
In addition, preparing the mouthwash based on beta-cyclodextrin for method provided by the invention, include the following steps：
S201：Propolis, solubilizer, wetting agent and menthol are uniformly mixed, the first solution is obtained.
S202：Plant extracts, acidity regulator, xylitol and beta-cyclodextrin are uniformly mixed, the second solution is obtained.
S203：Mixing after second solution is added in the first solution is added deionized water and is sufficiently stirred, filters later
And filtrate is collected, obtain mouthwash.
Embodiment three
The present embodiment provides a kind of mouthwash based on beta-cyclodextrin, in every 100 parts by weight mouthwash, including：Propolis
0.01 parts by weight, 5.0 parts by weight of Crodaret RH40,0.1 parts by weight of beta-cyclodextrin, 30 parts by weight of sorbierite,
0.05 parts by weight of acidity regulator sodium citrate, 0.5 parts by weight of menthol, 5 parts by weight of plant extracts, 0.5 weight of xylitol
Part, surplus is deionized water.Wherein, in plant extracts, the raw material components of plant by weight, including：2 weight of orchid
Part, 5 parts by weight of jasmine, 3 parts by weight of FLOS CHRYSANTHEMI ALBA from Haizhou of China, 2 parts by weight of wild chrysanthemum, 3 parts by weight of sophora flower, 1 parts by weight of rose, 6 weight of sweet osmanthus
Part, 3 parts by weight of product shell, 1.5 parts by weight of 0.1 parts by weight of amplexicaul jasmine leaf and rhizoma anemarrhenae；The preparation method of plant extracts includes following step
Suddenly：S101：It is crushed after each plant is cleaned, dried；S102：It is adopted after FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid after crushing is mixed
It is extracted with steam distillation, and 5 times that the addition of water is FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid gross mass, later mistake
It filters and collects the first filtrate；By the surplus stock component after crushing use mass percentage concentration for 30% sodium citrate aqueous solution
It impregnates, carries out Microwave Extraction later, filter and collect the second filtrate；Microwave power is 1000MHz, and temperature is 75 DEG C, and the time is
100min；S103：First filtrate and the second filtrate are mixed, heating later is concentrated into the 1/2 of original volume.
In addition, preparing the mouthwash based on beta-cyclodextrin for method provided by the invention, include the following steps：
S201：Propolis, solubilizer, wetting agent and menthol are uniformly mixed, the first solution is obtained.
S202：Plant extracts, acidity regulator, xylitol and beta-cyclodextrin are uniformly mixed, the second solution is obtained.
S203：Mixing after second solution is added in the first solution is added deionized water and is sufficiently stirred, filters later
And filtrate is collected, obtain mouthwash.
Example IV
The present embodiment provides a kind of mouthwash based on beta-cyclodextrin, in every 100 parts by weight mouthwash, including：Propolis 2.0
Parts by weight, 0.5 parts by weight of polysorbate60,2.0 parts by weight of beta-cyclodextrin, 10 parts by weight of glycerine, 0.5 weight of acidity regulator malic acid
Part, 0.01 parts by weight of menthol, 20 parts by weight of plant extracts, 0.05 parts by weight of xylitol are measured, surplus is deionized water.Its
In, in plant extracts, the raw material components of plant by weight, including：1 parts by weight of orchid, 3 parts by weight of jasmine, FLOS CHRYSANTHEMI ALBA from Haizhou of China 1
Parts by weight, 5 parts by weight of wild chrysanthemum, 2 parts by weight of sophora flower, 2 parts by weight of rose, 3 parts by weight of sweet osmanthus, 1 parts by weight of product shell, amplexicaul jasmine leaf
0.5 parts by weight of 0.5 parts by weight and rhizoma anemarrhenae；The preparation method of plant extracts includes the following steps：S101：Each plant is cleaned,
It is crushed after drying；S102：It is carried using steam distillation after FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid after crushing is mixed
It takes, and 8 times that the addition of water is FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid gross mass, filters later and collect the first filtrate；It will
Surplus stock component after crushing uses mass percentage concentration to be impregnated for 10% sodium citrate aqueous solution, carries out microwave later and carries
It takes, filter and collects the second filtrate；Microwave power is 1200MHz, temperature 65, time 200min；S103：By the first filtrate
It is mixed with the second filtrate, heating later is concentrated into the 2/3 of original volume.
In addition, preparing the mouthwash based on beta-cyclodextrin for method provided by the invention, include the following steps：
S201：Propolis, solubilizer, wetting agent and menthol are uniformly mixed, the first solution is obtained.
S202：Plant extracts, acidity regulator, xylitol and beta-cyclodextrin are uniformly mixed, the second solution is obtained.
S203：Mixing after second solution is added in the first solution is added deionized water and is sufficiently stirred, filters later
And filtrate is collected, obtain mouthwash.
In addition, in order to further highlight the advantage of mouthwash technical solution of the present invention, following contrast experiment is carried out.It needs
Bright, following comparative examples are arranged on the basis of example IV.
Comparative example one
This comparative example provides a kind of mouthwash based on beta-cyclodextrin, in every 100 parts by weight mouthwash, including：Propolis 2.0
Parts by weight, 0.5 parts by weight of polysorbate60,2.0 parts by weight of beta-cyclodextrin, 10 parts by weight of glycerine, 0.5 weight of acidity regulator malic acid
Part, 0.01 parts by weight of menthol, 20 parts by weight of plant extracts, 0.05 parts by weight of xylitol are measured, surplus is deionized water.Its
In, in plant extracts, the raw material components of plant by weight, including：1 parts by weight of orchid, 3 parts by weight of jasmine, FLOS CHRYSANTHEMI ALBA from Haizhou of China 1
Parts by weight, 5 parts by weight of wild chrysanthemum, 2 parts by weight of sophora flower, 2 parts by weight of rose, 3 parts by weight of sweet osmanthus, 1 parts by weight of product shell, amplexicaul jasmine leaf
0.5 parts by weight of 0.5 parts by weight and rhizoma anemarrhenae；The preparation method of plant extracts includes the following steps：S101：Each plant is cleaned,
It is crushed after drying；S102：It is carried using steam distillation after FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid after crushing is mixed
It takes, and 8 times that the addition of water is FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid gross mass, filters later and collect the first filtrate；It will
Surplus stock component after crushing is soaked in water, and carries out Microwave Extraction later, filters and collects the second filtrate；Microwave power is
1200MHz, temperature 65, time 200min；S103：First filtrate and the second filtrate are mixed, heating later is concentrated into original
The 2/3 of volume.
In addition, preparing the mouthwash based on beta-cyclodextrin for method provided by the invention, include the following steps：
S201：Propolis, solubilizer, wetting agent and menthol are uniformly mixed, the first solution is obtained.
S202：Plant extracts, acidity regulator, xylitol and beta-cyclodextrin are uniformly mixed, the second solution is obtained.
S203：Mixing after second solution is added in the first solution is added deionized water and is sufficiently stirred, filters later
And filtrate is collected, obtain mouthwash.
Comparative example two
This comparative example provides a kind of mouthwash based on beta-cyclodextrin, in every 100 parts by weight mouthwash, including：Propolis 2.0
Parts by weight, 0.5 parts by weight of polysorbate60,2.0 parts by weight of beta-cyclodextrin, 10 parts by weight of glycerine, 0.5 weight of acidity regulator malic acid
Part, 0.01 parts by weight of menthol, 20 parts by weight of plant extracts, 0.05 parts by weight of xylitol are measured, surplus is deionized water.Its
In, in plant extracts, the raw material components of plant by weight, including：1 parts by weight of orchid, 3 parts by weight of jasmine, FLOS CHRYSANTHEMI ALBA from Haizhou of China 1
Parts by weight, 5 parts by weight of wild chrysanthemum, 2 parts by weight of sophora flower, 2 parts by weight of rose, 3 parts by weight of sweet osmanthus, 1 parts by weight of product shell, amplexicaul jasmine leaf
0.5 parts by weight of 0.5 parts by weight and rhizoma anemarrhenae；The preparation method of plant extracts includes the following steps：S101：Each plant is cleaned,
It is crushed after drying；S102：It is carried using steam distillation after FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid after crushing is mixed
It takes, and 8 times that the addition of water is FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid gross mass, filters later and collect the first filtrate；It will
Surplus stock component after crushing uses mass percentage concentration to be impregnated for 10% aqueous citric acid solution, carries out microwave later and carries
It takes, filter and collects the second filtrate；Microwave power is 1200MHz, temperature 65, time 200min；S103：By the first filtrate
It is mixed with the second filtrate, heating later is concentrated into the 2/3 of original volume.
In addition, preparing the mouthwash based on beta-cyclodextrin for method provided by the invention, include the following steps：
S201：Propolis, solubilizer, wetting agent and menthol are uniformly mixed, the first solution is obtained.
S202：Plant extracts, acidity regulator, xylitol and beta-cyclodextrin are uniformly mixed, the second solution is obtained.
S203：Mixing after second solution is added in the first solution is added deionized water and is sufficiently stirred, filters later
And filtrate is collected, obtain mouthwash.
Comparative example three
This comparative example provides a kind of mouthwash based on beta-cyclodextrin, in every 100 parts by weight mouthwash, including：Propolis 2.0
Parts by weight, 0.5 parts by weight of polysorbate60,2.0 parts by weight of beta-cyclodextrin, 10 parts by weight of glycerine, 0.5 weight of acidity regulator malic acid
Part, 0.01 parts by weight of menthol, 20 parts by weight of plant extracts, 0.05 parts by weight of xylitol are measured, surplus is deionized water.Its
In, in plant extracts, the raw material components of plant by weight, including：1 parts by weight of orchid, 3 parts by weight of jasmine, FLOS CHRYSANTHEMI ALBA from Haizhou of China 1
Parts by weight, 5 parts by weight of wild chrysanthemum, 2 parts by weight of sophora flower, 2 parts by weight of rose, 3 parts by weight of sweet osmanthus, product 1 parts by weight of shell and rhizoma anemarrhenae 0.5
Parts by weight；The preparation method of plant extracts includes the following steps：S101：It is crushed after each plant is cleaned, dried；S102：It will
It is extracted using steam distillation after FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid mixing after crushing, and the addition of water is Hangzhoupro
8 times of feverfew, sophora flower, rose and orchid gross mass, filter and collect the first filtrate later；By the surplus stock component after crushing
It uses mass percentage concentration to be impregnated for 10% sodium citrate aqueous solution, carries out Microwave Extraction later, filter and collect the second filter
Liquid；Microwave power is 1200MHz, temperature 65, time 200min；S103：First filtrate and the second filtrate are mixed, later
Heating is concentrated into the 2/3 of original volume.
In addition, preparing the mouthwash based on beta-cyclodextrin for method provided by the invention, include the following steps：
S201：Propolis, solubilizer, wetting agent and menthol are uniformly mixed, the first solution is obtained.
S202：Plant extracts, acidity regulator, xylitol and beta-cyclodextrin are uniformly mixed, the second solution is obtained.
S203：Mixing after second solution is added in the first solution is added deionized water and is sufficiently stirred, filters later
And filtrate is collected, obtain mouthwash.
Comparative example four
This comparative example provides a kind of mouthwash based on beta-cyclodextrin, in every 100 parts by weight mouthwash, including：Propolis 2.0
Parts by weight, 0.5 parts by weight of polysorbate60,2.0 parts by weight of beta-cyclodextrin, 10 parts by weight of glycerine, 0.5 weight of acidity regulator malic acid
Part, 0.01 parts by weight of menthol, 20 parts by weight of plant extracts, 0.05 parts by weight of xylitol are measured, surplus is deionized water.Its
In, in plant extracts, the raw material components of plant by weight, including：1 parts by weight of orchid, 3 parts by weight of jasmine, FLOS CHRYSANTHEMI ALBA from Haizhou of China 1
Parts by weight, 5 parts by weight of wild chrysanthemum, 2 parts by weight of sophora flower, 0.5 parts by weight of 2 parts by weight of rose, 3 parts by weight of sweet osmanthus and rhizoma anemarrhenae；Plant
The preparation method of extract includes the following steps：S101：It is crushed after each plant is cleaned, dried；S102：By the Hang Bai after crushing
It is extracted using steam distillation after chrysanthemum, sophora flower, rose and orchid mixing, and the addition of water is FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose
It is 8 times rare and orchid gross mass, it filters later and collects the first filtrate；Surplus stock component after crushing is used into quality percentage
A concentration of 10% sodium citrate aqueous solution impregnates, and carries out Microwave Extraction later, filters and collect the second filtrate；Microwave power is
1200MHz, temperature 65, time 200min；S103：First filtrate and the second filtrate are mixed, heating later is concentrated into original
The 2/3 of volume.
In addition, preparing the mouthwash based on beta-cyclodextrin for method provided by the invention, include the following steps：
S201：Propolis, solubilizer, wetting agent and menthol are uniformly mixed, the first solution is obtained.
S202：Plant extracts, acidity regulator, xylitol and beta-cyclodextrin are uniformly mixed, the second solution is obtained.
S203：Mixing after second solution is added in the first solution is added deionized water and is sufficiently stirred, filters later
And filtrate is collected, obtain mouthwash.
Comparative example five
This comparative example provides a kind of mouthwash based on beta-cyclodextrin, in every 100 parts by weight mouthwash, including：Propolis 2.0
Parts by weight, 0.5 parts by weight of polysorbate60,2.0 parts by weight of beta-cyclodextrin, 10 parts by weight of glycerine, 0.5 weight of acidity regulator malic acid
Part, 0.01 parts by weight of menthol, 0.05 parts by weight of xylitol are measured, surplus is deionized water.
In addition, preparing the mouthwash based on beta-cyclodextrin for method provided by the invention, include the following steps：
S201：Propolis, solubilizer, wetting agent and menthol are uniformly mixed, the first solution is obtained.
S202：Acidity regulator, xylitol and beta-cyclodextrin are uniformly mixed, the second solution is obtained.
S203：Mixing after second solution is added in the first solution is added deionized water and is sufficiently stirred, filters later
And filtrate is collected, obtain mouthwash.
The mouthwash that various embodiments of the present invention are prepared, by function assessment experiment come its effect of system evaluation：
One, toxicity test
It is the small white mouse 40 (each 20 of male and female) of 18~22g to select weight, is divided into 4 groups, tries out the present invention respectively and implements
The mouthwash that example one to example IV obtains.Specifically, every small white mouse gives concentrate 1.5mL gavages, twice daily；Observation
30 days, small white mouse health existence was without any side effects；Blood picture, liver function, each organs and tissues state is dissected and observed, and just
Normal small white mouse compares indifference.It is demonstrated experimentally that mouthwash provided by the invention is nontoxic.
Two, extracorporeal bacteria inhibitor test
It is experimental subjects to select staphylococcus aureus, Escherichia coli and Haemolysis Vibrio, to each embodiment and comparative example
The mouthwash being prepared carries out extracorporeal bacteria inhibitor test respectively.
Specific experiment method is：Take a small amount of bacterium in equipped with 50mL liquid beef-protein mediums with oese,
For 24 hours, spread plate detects spare shaking table culture at 37 DEG C.After culture medium completely solidification, with 0.8cm card punch in culture dish
It is upper it is equidistant make a call to three holes, remove culture medium in hole；The sample solution of 120 μ L, blank control are injected in each hole with liquid-transfering gun
The normal saline solution that equivalent is injected in group hole, is placed in 37 DEG C, is cultivated under 70% damp condition for 24 hours, and crossing method measures
Antibacterial circle diameter evaluates bacteriostatic experiment as a result, specific as shown in table 1.
The bacteriostatic test data list of 1 each embodiment and comparative example mouthwash of table
It can be seen that the mouthwash that various embodiments of the present invention are prepared is to Haemolysis Vibrio, Escherichia coli and golden yellow
Staphylococcus has apparent inhibiting effect, and bacteriostasis is significantly better than each control group.
Three, clinical test
18~60 years old halitosis volunteer of call-up age 540；Wherein, halitosis is divided into six grades using direct smell method,
Grade scale is as follows：Zero level：Without halitosis；Level-one：Very slight halitosis；Two level：Slight halitosis；Three-level：Moderate halitosis；Four
Grade：Strong halitosis；Pyatyi：Halitosis strongly.Specifically, all kinds of volunteers are divided into 9 groups, i.e., every group include three-level,
Level Four and each 20 of Pyatyi halitosis volunteer；Wherein, first group to the 4th group difference trial edition inventive embodiments one are to embodiment
Four mouthwash, the mouthwash of the 5th group to the 9th group comparative example one on probation to comparative example five.
Test method：Using above-mentioned mouthwash 30s, each volunteer is assessed later and is gargled the halitosis situation of 2h and 5h.
Wherein, it is effective that rank, which reduces two level or more person,；It is effective to reduce level-one person；Unchanged person is invalid；Concrete condition such as table 2
Shown in table 3.
Table 2 uses effect table after each embodiment and comparative example mouthwash 2h
Table 3 uses effect table after each embodiment and comparative example mouthwash 5h
It is examined in addition, volunteer makees pairing t- in front and back halitosis rank value of gargling, pairing t- inspection results are significant
(P ＜ 0.01).And it can be seen that from table 2 and 3 data of table：Compared to control group, the halitosis of test group volunteer removes effect
Fruit is more notable, while the oral inflammations such as periodontitis have clear improvement, and taste is more easy to be received.
Certainly, prepared by the case where being enumerated in addition to embodiment one to example IV, the weight percent of other raw material components
Condition in journey is also possible.
Mouthwash provided by the invention, the absorption principle based on beta-cyclodextrin, raw material selection and proportioning science, not containing alcohol and
Chemical antiseptic, it is safe and non-stimulating, the work(such as not only there is excellent antibacterial, anti-inflammatory, antiulcer, removal implication and refresh the mind
Effect, and the bad smell of propolis can be effectively covered, it disclosure satisfy that the needs of various people.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office
It can be combined in any suitable manner in one or more embodiments or example.In addition, without conflicting with each other, the skill of this field
Art personnel can tie the feature of different embodiments or examples described in this specification and different embodiments or examples
It closes and combines.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example
Property, it is not considered as limiting the invention, those skilled in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, changes, replacing and modification.
Claims (9)
1. a kind of mouthwash based on beta-cyclodextrin, it is characterised in that：
In mouthwash described in every 100 parts by weight, including following raw material components：0.01~2.0 parts by weight of propolis, solubilizer 0.5~
5.0 parts by weight, 0.1~2.0 parts by weight of beta-cyclodextrin, 10~30 parts by weight of wetting agent, 0.05~0.5 weight of acidity regulator
Part, 0.01~0.5 parts by weight of menthol, 1.0~20 parts by weight of plant extracts, surplus is deionized water.
2. the mouthwash according to claim 1 based on beta-cyclodextrin, it is characterised in that：
The solubilizer includes：It is one or more in Crodaret, polysorbate60 and span 40；The wetting agent
Including：Glycerine and/or sorbierite；The acidity regulator includes：One kind or more in citric acid, sodium citrate and malic acid
Kind.
3. the mouthwash according to claim 1 based on beta-cyclodextrin, it is characterised in that：
The raw material components further include 0.05~0.5 parts by weight of xylitol.
4. according to mouthwash of the claims 1 to 3 any one of them based on beta-cyclodextrin, it is characterised in that：
Plant material in the plant extracts includes in orchid, jasmine, FLOS CHRYSANTHEMI ALBA from Haizhou of China, wild chrysanthemum, sophora flower, rose or sweet osmanthus
It is one or more；
Wherein, the raw material components of the plant by weight, including：1~2 parts by weight of orchid, 3~5 parts by weight of jasmine, Hang Bai
1~3 parts by weight of chrysanthemum, 2~5 parts by weight of wild chrysanthemum, 3~6 parts by weight of 2~3 parts by weight of sophora flower, 1~2 parts by weight of rose and sweet osmanthus.
5. the mouthwash according to claim 4 based on beta-cyclodextrin, it is characterised in that：
The raw material components of the plant by weight, further include：Product shell 1~3 parts by weight, 0.1~0.5 parts by weight of amplexicaul jasmine leaf and
0.5~1.5 parts by weight of rhizoma anemarrhenae.
6. the mouthwash according to claim 5 based on beta-cyclodextrin, it is characterised in that：
The preparation method of the plant extracts includes the following steps：
S101：It is crushed after each plant is cleaned, dried；
S102：It is extracted using steam distillation after FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid after crushing is mixed, later
It filters and collects the first filtrate；Surplus stock component after crushing is impregnated, Microwave Extraction is carried out later, filters and collect second
Filtrate；
S103：First filtrate and the second filtrate are mixed, heating later is concentrated into the 1/2~2/3 of original volume.
7. the mouthwash according to claim 6 based on beta-cyclodextrin, it is characterised in that：
In the S102：
In the steam distillation, the addition of water is 5~8 times of the FLOS CHRYSANTHEMI ALBA from Haizhou of China, sophora flower, rose and orchid gross mass；
In the Microwave Extraction, microwave power be 1000MHz~1200MHz, temperature be 65~75 DEG C, the time be 100~
200min；
Surplus stock component after crushing is used to the aqueous solution soaking of sodium citrate, and the quality of the sodium citrate aqueous solution
Percentage concentration is 10~30%.
8. preparation method of claim 1~7 any one of them based on beta-cyclodextrin mouthwash, which is characterized in that including with
Lower step：
S201：Propolis, solubilizer, wetting agent and menthol are uniformly mixed, the first solution is obtained；
S202：Plant extracts, acidity regulator, xylitol and beta-cyclodextrin are uniformly mixed, the second solution is obtained；
S203：Mixing after second solution is added in first solution is added deionized water and is sufficiently stirred later,
Filtrate is filtered and collected, the mouthwash is obtained.
9. described in any one of claim 1~7 based on the mouthwash of beta-cyclodextrin prepare fresh breath, go removing abnormal flavor in oral cavity,
Application in inhibition oral bacteria, anti-oral ulcer and anti-caries tooth product and/or product additive.
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| CN108324661B (en) | 2021-12-21 |
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