CN108309952A - A kind of anti-ultraviolet cellulose hollow capsule shells - Google Patents
A kind of anti-ultraviolet cellulose hollow capsule shells Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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Abstract
A kind of cellulose hollow capsule shells, which is characterized in that capsule wall tool haves three layers or 3 layers or more of base layer structure, each base layer all contain hypromellose, and the thickness-tapered of each base layer from outside to inside on the thickness direction of capsule wall.Interface between the substrate layer that the cellulose hollow capsule shells of the present invention pass through multilayer different-thickness is to the reflecting effect of ultraviolet light, the rate that pigment is decomposed by ultraviolet light irradiation in cellulose hollow capsule shells is reduced, the holding time of colored fibre element Capsules shell is extended.
Description
Technical field
The present invention relates to a kind of cellulose hollow capsule shells, and in particular to a kind of anti-ultraviolet cellulose hollow capsule
Shell.
Background technology
Capsules refer to the bladder made of extraordinary filmogen (such as gelatin, cellulose, polysaccharide etc.) in medicine,
Content (such as powdery, liquid various kinds of drug) is packed into wherein, convenient for swallowing.The drug filled with capsule, typically to food
Road and gastric mucosa powder excitatory or particle or mouthfeel are bad, are easy to volatilization, are easily decomposed in the oral cavity by saliva, and
The easily medicine of sucking tracheae.These medicines are packed into capsule, both medicine property of medicine are protected not to be destroyed, and also protect digestive organs and breathing
Road.Remove capsule shells and is likely to result in drug wastage, drug waste, drug effect reduction.
Capsule without containing pigment is that colourless (or yellowish) is transparent.Some drugs are due to its special shape or face
Color can influence the mood of patient, therefore patient is not intended to see；Also some drugs are light-exposed can decompose and lose drug effect, need to carry out
Shading treatment；In addition, being sometimes also required to increase the identification of capsule.In order to achieve the above object, people would generally be in capsule
The middle pigment that a variety of colors is added, makes capsule carry color.
But under normal circumstances, the pigment used in capsule especially organic pigment can decompose under ultraviolet irradiation
And discoloration occur, fade, aberration is generated, the appearance of coloured capsule is influenced.Therefore a kind of anti-ultraviolet capsule is needed to solve
The above problem.Chinese patent CN201511015142.6, which is disclosed, a kind of absorbing purple with capsule is added in nano silicon dioxide
The method of outside line and its capsule of preparation；Chinese patent CN201511015141.1 is disclosed a kind of to be added with by nano zine oxide
Enter capsule to absorb the method for ultraviolet light and its capsule of preparation.But the inorganic matter that the above method uses all is whiteness, no
Conducive to the color of accuracy controlling capsule；Nano-substance is difficult to be uniformly dispersed in capsule, can exist due to nano-substance in capsule
The white point of reunion generation, raised the defects of point, influence the appearance and mechanical property of capsule.
Invention content
To solve the above-mentioned problems, the present invention provides a kind of anti-ultraviolet cellulose hollow capsule shells, capsule walls
Tool haves three layers or 3 layers or more of base layer structure, and each base layer all contains hypromellose, and in thickness direction
On each base layer from outside to inside thickness-tapered.
Interface between the substrate layer that the cellulose hollow capsule shells of the present invention pass through multilayer different-thickness is to ultraviolet light
Reflecting effect reduces pigment in cellulose hollow capsule shells and it is plain empty to extend colored fibre by the rate that ultraviolet light irradiates and decomposes
The holding time of heart-soothing capsule shell.The number of plies is very little, and interface is few, bad to the reflecting effect of ultraviolet light, cannot inhibit cellulose very well
Discoloration, colour fading of the pigment under ultraviolet light irradiation in Capsules shell.Each matrix from outside to inside on the thickness direction of capsule wall
The thickness-tapered of layer can increase reflecting effect of the interface between each base layer to ultraviolet light, reduce cellulose hollow capsule shells
Discoloration, fade rates.Wherein, refer to capsule on the inside of the capsule wall after loading content, directly connect with content
Tactile side；Outside refers to the side being in contact with external environment.Described successively decreases comprising monotone decreasing, and monotone decreasing is in capsule
It is less than or equal to the thickness of adjacent each base layer compared with outside on the thickness direction of wall compared with the thickness of each base layer of inside.
In the capsule wall of the present invention, each base layer all contains hypromellose.Hypromellose is a kind of non-
The cellulose mixing ether of ionic is common raw material in plant fiber cellulose capsule, relative to other celluloses, comprehensive performance compared with
It is good, and mass production, there is price advantage.The manufacturer of hypromellose has carefree group of South Korea, Shandong are conspicuous to reach stock
Part company etc..The content of methoxyl group is generally 10%~30%, preferably 15%~25%, propoxyl in hydroxypropyl methylcellulose
Content is generally 4%~12%, preferably 5~10%.
Further, the thickness of each base layer of capsule wall of the cellulose hollow capsule shells is 5~80 μm.Inventor
It was found that the thickness of each substrate layer is preferable to the reflecting effect of ultraviolet light within the scope of this, the mechanical property of Capsules shell also compared with
It is excellent, and preparation process is simple.Preferably, the thickness of each base layer of capsule wall of the cellulose hollow capsule shells is 20~60
μm。
Further, the cellulose hollow capsule shells on the thickness direction of capsule wall from outside to inside, each base layer
The methoxyl content (A%) of middle hypromellose successively decreases.Described successively decreasing refers to monotone decreasing.Inventor has found there is this
The capsule wall of kind of feature may be implemented to improve the effect of interface between substrate layer to the albedo of ultraviolet light.
Further, the cellulose hollow capsule shells on the thickness direction of capsule wall from outside to inside, each base layer
The hydroxypropoxy content (B%) of middle hypromellose successively decreases.Described successively decreasing refers to monotone decreasing.Inventor has found, has
The capsule wall of this feature can further realize effect of the interface between improving substrate layer to the albedo of ultraviolet light.
Further, contain ultraviolet absorber in each base layer of cellulose hollow capsule shells.
Wherein, ultraviolet absorber refers to the substance that can absorb ultraviolet light, specifically comprising salicylic acid esters, benzophenone,
Benzotriazole, group-substituted acrylonitrile, triazines, Flavonoids, plant polyphenol kind, plant anthraquinone etc..Pass through each substrate layer
In ultraviolet absorber absorb ultraviolet light, further decrease pigment in cellulose hollow capsule shells and become because being irradiated by ultraviolet light
Color, colour fading speed, extend colored fibre element Capsules shell holding time.
Further, the mass percentage of ultraviolet absorber is in each base layer of cellulose hollow capsule shells
0.05%~2%.When the ultraviolet absorber in each base layer mass percentage be less than 0.05%, cellulose hollow capsule shells
UV resistant ability it is relatively low, the discoloration of cellulose hollow capsule shells, fade rates are very fast, and the holding time is shorter；Work as matrix
When the mass percentage of ultraviolet absorber in layer is more than 2%, the ultraviolet-resistant capacity of cellulose hollow capsule shells is not
It significantly improves, but the other performances such as mechanical performance can reduce, and cost increases.
Further, the mass percentage ＞ (A%+B%)/40 of the ultraviolet absorber in each base layer, and
＜ 2%.When the mass percentage of ultraviolet absorber in each base layer of cellulose hollow capsule shells is within the scope of this, fiber
The comprehensive performances such as ability, the mechanical property of UV resistant of plain Capsules shell are all more excellent.
Further, cellulose hollow capsule shells on the thickness direction of capsule wall from outside to inside, the purple in each base layer
The mass percentage of outer absorbent is reduced.Since ultraviolet light is irradiated to inside capsule wall from outside to inside by capsule wall, institute
Most started with the ultraviolet absorber of outer layer substrate layer and action of ultraviolet radiation, absorption ultraviolet light more arrive capsule wall internal layer, ultraviolet light is strong
Degree is weaker, by gradually decreasing the content of ultraviolet absorber in each substrate layer of capsule wall from outside to inside, is ensureing ultraviolet absorber
There is enough absorbabilities to ultraviolet light, while ensureing that pigment has enough holding times in capsule wall, reduce in capsule wall
The additive amount of ultraviolet absorber, it is cost-effective, improve the mechanical performance of capsule wall.
Further, the ultraviolet absorber is salicylic acid esters, Flavonoids, plant polyphenol kind or plant anthraquinone
In it is one or more.
Salicylic acid esters refer to the substance containing ester bond that the substance reaction of salicylic acid and hydroxyl obtains, include specifically but
It is not limited to gaultherolin, 1-Hexyl salicylate, glycol salicylate, homosalate, 4- octyl benzene
It is one or more in base salicylate, menthol salicylate or benzyl salicylate etc..
Plant polyphenol kind is specifically including but not limited to one in tea polyphenols, anthocyanidin, flavanol compound, phenolic acid class or catechin
Kind is a variety of.
Plant anthraquinone is mainly derivative in hydroxy anthraquinones category, is specifically including but not limited to rheum emodin, Rhein, rheum emodin first
It is one or more in ether, Chrysophanol or aloe-emodin.
Further, the ultraviolet absorber is the mixing of homosalate and aloe-emodin
Object.Inventor has found that homosalate and aloe-emodin have synergistic effect to the absorption of ultraviolet light,
The cellulose hollow capsule shells containing above two ultraviolet absorber are more preferable to the assimilation effect of ultraviolet light simultaneously.
Further, in the mixture of the homosalate and aloe-emodin, with bigcatkin willow
Acid 3,3,5- 3-methyl cyclohexanol esters are 100 parts by weight meters, contain 100~500 parts by weight of aloe-emodin.When the ultraviolet suction of substrate layer
Receive agent in the mass ratio of homosalate and aloe-emodin within the above range when, two kinds of UV absorptions
The synergistic effect of agent is more preferable, and ultraviolet absorption ability is stronger.Preferably, the homosalate and reed
In the mixture of luxuriant growth rheum emodin, by homosalate be 100 parts by weight in terms of, contain aloe-emodin 200
~400 parts by weight.
Known Capsules shell preparation method may be used in the preparation method of cellulose hollow capsule shells of the present invention,
Concrete example is as follows：
1, the raw material of each layer substrate layer and coat of colo(u)r is uniformly mixed according to corresponding proportioning and is dissolved in water, be made respectively
The aqueous solution of raw material of each layer.
2, by capsule die according to sequencing from inside to outside, the raw material of each layer of substrate layer or coat of colo(u)r is immersed successively
Aqueous solution is simultaneously dried, then immerses aqueous solution of raw material and the drying of next layer of substrate layer, and finally demoulding suits to obtain the fibre of the present invention
The plain Capsules shell of dimension.
Further, cellulose hollow capsule shells of the invention also have following performance：
Friability：It is crushed capsule in 50 and is no more than 5；
Disintegration time limited ＜ 10min；
Content of beary metal ＜ 40ppm.
Wherein, the mechanical strength of the friability reaction capsule of capsule ensures that cellulose hollow capsule shells are being packed and transported
There is very low breakage rate in the process.
Disintegration refers to that all disintegration is leached or at particle, except insoluble coating material or broken solid pharmaceutical preparation under prescribed conditions
Outside broken capsule shells, it should all pass through sieve.Disintegration time limited refers to solid pharmaceutical preparation in defined medium, in defined manner into
Row checks that all disintegration leaches or at particle and by the limit the time required to sieve.In general, disintegration time limited is shorter, capsule
The therapeutic effect of agent is better.
Content of beary metal refers to the percentage composition of heavy metal in cellulose hollow capsule shells, and heavy metal is hazardous to the human body,
Its content is lower, smaller to the harm of human body.
The above performance can be measured according to the method that Chinese Pharmacopoeia is recorded.
Further, the present invention also provides a kind of capsules, contain above-mentioned cellulose hollow capsule shells.
Bed boundary between the substrate layer for passing through multilayer different-thickness the present invention provides a kind of cellulose hollow capsule shells
To the reflecting effect of ultraviolet light, the rate that pigment is decomposed by ultraviolet light irradiation in cellulose hollow capsule shells is reduced, extension has
The holding time of color fibre element Capsules shell.
Further, in each substrate layer of cellulose hollow capsule shells capsule wall of the invention also include thickness along capsule wall
The ultraviolet absorber that mass percentage successively decreases from outside to inside on direction is spent, in the additive amount for reducing ultraviolet absorber and ensures glue
Under the premise of capsule mechanical strength, absorption of the cellulose hollow capsule shells to ultraviolet light is improved, is reduced in cellulose hollow capsule shells
The decomposition rate of pigment improves its holding time.
It should be appreciated that the terms such as " having " used in the present invention, "comprising" and " comprising " are not precluded one
Or the presence or addition of a number of other substances, ingredient, performance, state, element or combinations thereof；" being more than ", " being less than " all do not include
Numerical value itself, " more than ", " following " all include numerical value itself.
Specific implementation mode
It is further illustrated the present invention below by the mode of embodiment, does not therefore limit the present invention to the embodiment
Among range.The techniques implemented on the basis of the foregoing are all within the scope of the present invention.For being familiar with this field
For personnel, other modifications may be easily implemented, therefore without departing substantially from general general defined by claim and equivalency range
Under thought, the present invention is not limited to specific details.
Test event of the present invention and its assay method are as follows, unless otherwise instructed, each test all at 25 DEG C into
Row.
1, capsule discoloration：With reference to GB/T16422.3-1997, coloured capsule sample is placed on and is provided with I type lamps
(UV-A340) in ultraviolet lighting case, ultraviolet light irradiation 2 hours is carried out at 25 DEG C.Ultraviolet light is tested using a colorimeter
The color change Δ E of capsule wall after pre-irradiation.
2, friability：By version in 2015《Chinese Pharmacopoeia》The test method of four gelatin hollow capsule friabilities is surveyed
Examination.
3, disintegration time limited：By version in 2015《Chinese Pharmacopoeia》The test method of four gelatin hollow capsule disintegration time limiteds carries out
Test.
4, content of beary metal：By version in 2015《Chinese Pharmacopoeia》The test method of four gelatin hollow capsule heavy metals carries out
Test.
5, thickness：It is measured using pachometer.
6, the methoxyl content (A%) of hypromellose：By version in 2015《Chinese Pharmacopoeia》Four hydroxypropyl fibres
The test method described in element is tieed up to be tested.
7, the hydroxypropyl content (B%) of hypromellose：By version in 2015《Chinese Pharmacopoeia》Four hydroxypropyls
Test method described in cellulose is tested.
<Hypromellose>
A1：The carefree production of South Korea, methoxyl content (A%) are 19.2%, and hydroxypropyl content (B%) is 7.1%；
A2：The carefree production of South Korea, methoxyl content (A%) are 21.7%, and hydroxypropyl content (B%) is 5.3%；
A3：The carefree production of South Korea, methoxyl content (A%) are 22.4%, and hydroxypropyl content (B%) is 8.5%；
A4：The carefree production of South Korea, methoxyl content (A%) are 23.8%, and hydroxypropyl content (B%) is 9.7%.
<Ultraviolet absorber>
B1：Glycol salicylate, the production of Hubei Ju Sheng Science and Technology Ltd.s；
B2：Catechin, the production of the Xi'an bio tech ltd La Weiya；
B3：Homosalate, the Shanghai bio tech ltd Yuan Ye is sold；
B4：Aloe-emodin, the production of Shanghai Yan Sheng Industrial Co., Ltd.s.
Embodiment 1~17
According to the raw material and its proportioning of substrate layer shown in Tables 1 and 2, the plant of the present invention is prepared according to following steps
Object Capsules shell.
Step 1, according to the first base material layer shown in Tables 1 and 2, the raw material of the second substrate layer and third substrate layer, press respectively
Its mass percentage is dissolved in water, add be equivalent to each layer material quality 0.5% beet red pigment (Shanghai Tianjin song industry have
Limit company produces), it is uniformly mixed and corresponding aqueous solution of raw material is prepared.
Step 2 immerses 0# hollow capsule molds in the first base material layer aqueous solution of raw material, and taking out drying makes capsule surface cover
Lid the first base material layer film.
The mold containing the first base material layer film obtained in step 2 is immersed in the second substrate layer raw water by step 3 again
In solution, taking out drying makes its surface cover one layer of second base material layer film.One layer is covered on it according still further to identical method
Third base material layer film.The thickness of each substrate layer is as Table 1 and Table 2 below.
Step 4 removes film from capsule die surface, cuts fitting, obtains the cellulose hollow capsule shells of the present invention.
Table 1：Content refers to the mass percentage of substance, and "/" indicates not containing the substance.
Table 2：Content refers to the mass percentage of substance, and the numerical value in " () " indicates the quality of two kinds of substances in mixture
Than.
Embodiment 18
On the basis of embodiment 17, the outer surface according to identical preparation method in third substrate layer is arranged one layer again
Substrate layer, wherein plant cellulose are identical with third substrate layer with the type of ultraviolet absorber, but the quality hundred of ultraviolet absorber
Point content is 1.4%, and the thickness along capsule wall each substrate layer from outside to inside is respectively 30 μm, 30 μm, 25 μm and 20 μm.
Embodiment 19
On the basis of embodiment 17, it is arranged between the second substrate layer and the first base material layer according to identical preparation method
One layer of substrate layer, wherein plant cellulose are identical with the second substrate layer with the type of ultraviolet absorber, but the matter of ultraviolet absorber
It is 0.9% to measure percentage composition, and the thickness along capsule wall each substrate layer from outside to inside is respectively 30 μm, 25 μm, 20 μm and 20 μm.
Embodiment 20
On the basis of embodiment 18, one layer of base is arranged in the inner surface according to identical preparation method in the first base material layer
Material layer, wherein plant cellulose are identical with the first base material layer with the type of ultraviolet absorber, but the quality percentage of ultraviolet absorber
Content is 0.8%, and the thickness along capsule wall each substrate layer from outside to inside is respectively 30 μm, 25 μm, 20 μm, 15 μm and 10 μm.
Comparative example 1
One kind is prepared according to the raw material and formula of third substrate layer structure in embodiment 1, and with reference to preparation method
Only include the plant fiber cellulose capsule of one layer of substrate layer structure.Wherein, the thickness of substrate layer is 100 μm.
Comparative example 2
It is prepared according to the raw material and formula of the second substrate layer in embodiment 1 and third substrate layer, and with reference to preparation method
Obtain it is a kind of include two layers of substrate layer structure plant fiber cellulose capsule.Wherein, the second base material layer thickness is 20 μm, third base material
Layer thickness is 80 μm.
The plant fiber cellulose capsule progressive energy that embodiment and comparative example is obtained according to test method provided by the invention
Test, test result are as shown in table 3.
Table 3
| Group | ΔE | Group | ΔE | Group | ΔE |
| Embodiment 1 | 3.5 | Embodiment 2 | 3.2 | Embodiment 3 | 3.0 |
| Embodiment 4 | 2.1 | Embodiment 5 | 2.8 | Embodiment 6 | 2.2 |
| Embodiment 7 | 2.6 | Embodiment 8 | 2.2 | Embodiment 9 | 2.3 |
| Embodiment 10 | 1.8 | Embodiment 11 | 1.5 | Embodiment 12 | 1.4 |
| Embodiment 13 | 1.2 | Embodiment 14 | 0.9 | Embodiment 15 | 0.8 |
| Embodiment 16 | 0.6 | Embodiment 17 | 0.5 | Embodiment 18 | 0.4 |
| Embodiment 19 | 0.4 | Embodiment 20 | 0.3 | / | / |
| Comparative example 1 | 5.5 | Comparative example 2 | 4.6 | / | / |
It is less than 5 in the friability 50 of the cellulose hollow capsule shells of the above embodiment of the present invention and comparative example, disintegration
Time limit ＜ 10min, content of beary metal ＜ 40ppm meet the requirement of Chinese Pharmacopoeia 2015 editions.It is measured from the color change Δ E of table 3
As a result as can be seen that the Δ E of the cellulose hollow capsule shells of embodiment after uv irradiation is both less than 4.0, and comparative example 1~
The Δ E of 2 cellulose hollow capsule shells is both greater than 4.0, illustrate the present invention cellulose hollow capsule shells can effectively slow down because
Discoloration, fade rates, extend the holding time of coloured capsule caused by ultraviolet light.
Claims (10)
1. a kind of cellulose hollow capsule shells, which is characterized in that capsule wall tool haves three layers or 3 layers or more of base layer structure, described
Each base layer all contain hypromellose, and the thickness-tapered of each base layer from outside to inside in a thickness direction.
2. cellulose hollow capsule shells according to claim 1, which is characterized in that the thickness of each base layer is 5~80 μm.
3. cellulose hollow capsule shells according to claim 1, which is characterized in that by outer on the thickness direction of capsule wall
And it is interior, the methoxyl content (A%) of the hypromellose in each base layer successively decreases.
4. cellulose hollow capsule shells according to claim 1, which is characterized in that by outer on the thickness direction of capsule wall
And it is interior, the hydroxypropoxy content (B%) of the hypromellose in each base layer successively decreases.
5. cellulose hollow capsule shells according to claim 1, which is characterized in that containing ultraviolet in each base layer
Absorbent.
6. cellulose hollow capsule shells according to claim 5, which is characterized in that in each base layer, the ultraviolet suction
The mass percentage for receiving agent is 0.05%~2%.
7. cellulose hollow capsule shells according to claim 6, which is characterized in that the ultraviolet suction in each base layer
Receive the mass percentage ＞ (A%+B%)/40 of agent, and ＜ 2%.
8. cellulose hollow capsule shells according to claim 7, which is characterized in that by outer on the thickness direction of capsule wall
And it is interior, the mass percentage of the ultraviolet absorber in each base layer is reduced.
9. cellulose hollow capsule shells according to claim 5, which is characterized in that the ultraviolet absorber is salicylic acid
It is one or more in esters, Flavonoids, plant polyphenol kind or plant anthraquinone.
10. cellulose hollow capsule shells according to claim 9, which is characterized in that the ultraviolet absorber is bigcatkin willow
The mixture of acid 3,3,5- 3-methyl cyclohexanols ester and aloe-emodin.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810292711.9A CN108309952A (en) | 2018-04-04 | 2018-04-04 | A kind of anti-ultraviolet cellulose hollow capsule shells |
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| CN201810292711.9A CN108309952A (en) | 2018-04-04 | 2018-04-04 | A kind of anti-ultraviolet cellulose hollow capsule shells |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081102A (en) * | 1992-07-09 | 1994-01-26 | 李友师 | A kind of novel plant sun agent |
| CN102119026A (en) * | 2008-06-13 | 2011-07-06 | 葛兰素集团有限公司 | Hydroxypropyl cellulose capsule shell |
| CN107496284A (en) * | 2017-08-21 | 2017-12-22 | 中山火炬职业技术学院 | A kind of natural composite plant ultraviolet absorber and its application |
| CN107648141A (en) * | 2017-10-27 | 2018-02-02 | 李创华 | A kind of sunscreen composition for absorbing ultraviolet |
-
2018
- 2018-04-04 CN CN201810292711.9A patent/CN108309952A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081102A (en) * | 1992-07-09 | 1994-01-26 | 李友师 | A kind of novel plant sun agent |
| CN102119026A (en) * | 2008-06-13 | 2011-07-06 | 葛兰素集团有限公司 | Hydroxypropyl cellulose capsule shell |
| CN107496284A (en) * | 2017-08-21 | 2017-12-22 | 中山火炬职业技术学院 | A kind of natural composite plant ultraviolet absorber and its application |
| CN107648141A (en) * | 2017-10-27 | 2018-02-02 | 李创华 | A kind of sunscreen composition for absorbing ultraviolet |
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