CN108309926A - A kind of thermo-sensitive gel agent and its preparation method and application - Google Patents
A kind of thermo-sensitive gel agent and its preparation method and application Download PDFInfo
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- CN108309926A CN108309926A CN201810184186.9A CN201810184186A CN108309926A CN 108309926 A CN108309926 A CN 108309926A CN 201810184186 A CN201810184186 A CN 201810184186A CN 108309926 A CN108309926 A CN 108309926A
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- sensitive gel
- gel agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Abstract
The present invention provides a kind of thermo-sensitive gel agent and its preparation method and application, the thermo-sensitive gel agent includes following raw material by weight percentage：Thermo-sensitive gel matrix 18%~22%, penetration enhancer 1%, remaining is water；The thermo-sensitive gel matrix is poloxamer188 and PLURONICS F87；The penetration enhancer is polyethylene glycol.Thermo-sensitive gel agent of the present invention can be used as Western medicine and middle drug carrier, after being applied to skin, is mutually mutated in medicine-feeding part generation, forms gel state, can effectively improve percutaneous penetration of drugs effect, improve drug bioavailability.
Description
Technical field
The invention belongs to field of pharmaceutical preparations more particularly to a kind of thermo-sensitive gel agent and its preparation method and application.
Background technology
Thermo-sensitive gel is a kind of novel modern drug delivery system, is existed with liquid form under low temperature, low consistency conditions, when
Environment temperature can occur rapidly to be mutually mutated when reaching critical micell temperature, form gel state in medicine-feeding part, make medicine-feeding part medicine
Object increased retention can delay drug release, improve bioavilability, be conducive to maintain local drug concentration, be suitable for part
Treatment.But as pharmaceutical carrier in application, Ligustrazine hydrochloride is ineffective, gelation temperature range is narrow for existing thermo-sensitive gel agent
It is narrow, and applicable drug range also has certain limitation.
Invention content
For the drawbacks described above in background technology, the main purpose of the present invention is to provide a kind of thermo-sensitive gel agent, can make
For Western medicine and middle drug carrier, after being applied to skin, mutually it is mutated in medicine-feeding part generation, forms gel state, can effectively improve
Percutaneous penetration of drugs effect improves drug bioavailability.
In order to achieve the above object, the present invention adopts the following technical scheme that：A kind of thermo-sensitive gel agent, including with weight percent
Than the following raw material of meter：Thermo-sensitive gel matrix 18%~22%, penetration enhancer 1%, remaining is water；The thermo-sensitive gel matrix
For poloxamer188 and PLURONICS F87；The penetration enhancer is polyethylene glycol.
As a further preference, the polyethylene glycol is selected from polyethylene glycol 2000, Macrogol 4000 and polyethylene glycol
6000。
As a further preference, the mass ratio of the poloxamer188 and PLURONICS F87 is 17：(1-5).
As a further preference, the gelation temperature of the thermo-sensitive gel carrier is 31-36 DEG C.
Another object of the present invention is to provide the preparation methods of above-mentioned thermo-sensitive gel agent, include the following steps：
1) poloxamer188 is added in purified water, stirring is put into refrigerator cold-storage until complete swelling；
2) PLURONICS F87, polyethylene glycol and water are added in through step 1) treated poloxamer188, stirring is mixed
It is even to get thermo-sensitive gel carrier.
As a further preference, in the step 1), the refrigerator cold-storage temperature is 2-5 DEG C.
Another object of the present invention is to provide the applications of above-mentioned thermo-sensitive gel agent, as Chinese medicine and the drug of Western medicine
Carrier.
As a further preference, the application process includes：
1) poloxamer188 is added in purified water, stirring is put into refrigerator cold-storage until complete swelling；
2) be added in through step 1) treated poloxamer188 PLURONICS F87, polyethylene glycol and and drug, mend
Water full dose, stirs and evenly mixs.
As a further preference, the drug is selected from Western medicine C14H10Cl2NNaO2 and Chinese medicine bletilla polysaccharide.
The beneficial effects of the invention are as follows：Thermo-sensitive gel agent of the present invention, including following raw material by weight percentage：It is temperature sensitive
Gel-type vehicle 18%~22%, penetration enhancer 1%, remaining is water；The thermo-sensitive gel matrix is poloxamer188 and pool Lip river
Husky nurse 188；The penetration enhancer is polyethylene glycol.Thermo-sensitive gel agent of the present invention is at 25 DEG C or less in the liquid of flowing
State after being applied to skin, is mutually mutated in medicine-feeding part generation, forms gel state, realization delays drug release, improves biological utilisation
Degree.Thermo-sensitive gel agent of the present invention can local topical and avoid first close from eliminating and reduce adverse reaction, while being liquid in vitro
Body state is easy to be administered, long in the medicine-feeding part residence time, the sustainable release of drug, makees in addition, the present invention adds polyethylene glycol
For penetration enhancer, percutaneous penetration of drugs effect can be effectively improved, drug bioavailability is further increased.
Description of the drawings
Fig. 1 is the C14H10Cl2NNaO2 thermo-sensitive gel release in vitro result feelings that gelation temperature is 32 DEG C in the embodiment of the present invention 3
Condition figure；
Fig. 2 is the C14H10Cl2NNaO2 thermo-sensitive gel release in vitro result feelings that gelation temperature is 34 DEG C in the embodiment of the present invention 3
Condition figure；
Fig. 3 is the C14H10Cl2NNaO2 thermo-sensitive gel release in vitro result feelings that gelation temperature is 36 DEG C in the embodiment of the present invention 3
Condition figure；
Fig. 4 is the bletilla polysaccharide thermo-sensitive gel release in vitro result situation that gelation temperature is 32 DEG C in the embodiment of the present invention 4
Figure；
Fig. 5 is the bletilla polysaccharide thermo-sensitive gel release in vitro result situation that gelation temperature is 34 DEG C in the embodiment of the present invention 4
Figure；
Fig. 6 is the bletilla polysaccharide thermo-sensitive gel release in vitro result situation that gelation temperature is 36 DEG C in the embodiment of the present invention 4
Figure.
Specific implementation mode
The present invention solves existing thermo-sensitive gel agent by a kind of thermo-sensitive gel agent of offer and its preparation method and application
Defect when being applied as pharmaceutical carrier.
In order to reach drawbacks described above, the main thought of the embodiment of the present invention is：
Thermo-sensitive gel agent of the embodiment of the present invention, including following raw material by weight percentage：Thermo-sensitive gel matrix 18%
~22%, penetration enhancer 1%, remaining is water；The thermo-sensitive gel matrix is poloxamer188 and PLURONICS F87；It is described
Penetration enhancer is polyethylene glycol.
Above-mentioned penetration enhancer is the polyethylene glycol close with poloxamer fusing point, and polyethylene glycol is a kind of hydrophily base
Matter, property is stablized, and to no skin irritation, has lubricity, can be used for gelling agent, and nontoxic, tasteless, with drug, matrix,
Skin has good compatibility, can be used as penetration enhancer, the barrier function of reversible change cuticula, and do not damage any work
Property cell, can improve Drug Percutaneous Absorption rate in gelling agent.The average molecular weight of polyethylene glycol is from 200-20000, originally
Embodiment can select polyethylene glycol 2000, polyethylene glycol of the fusing point between 30 to 40 degree according to the physical property of polyethylene glycol
4000 and Macrogol 6000.
Gelation temperature, such as skin can be changed by adjusting the ratio of PLURONICS F87 and polyethylene glycol in the embodiment of the present invention
Skin temperature 32 is used for temperature high point of the gelation temperature than skin of areas of inflammation.
Therefore, an embodiment of the present invention provides one kind using poloxamer188 and PLURONICS F87 as temperature sensing material, with poly-
Ethylene glycol is the thermo-sensitive gel matrix of penetration enhancer, and as the pharmaceutical carrier of local topical administration, Transdermal absorption is good, as
When pharmaceutical carrier, at 25 DEG C or less in the liquid condition of flowing, after being applied to skin, mutually it is mutated, is formed in medicine-feeding part generation
Gel state, realization delay drug release, improve bioavilability.
Material used in the embodiment of the present invention, reagent, instrument etc., are commercially available unless otherwise specified,
And material, reagent, reaction title, instrument title etc. are this field general term.
It is further described in detail below for the above, but the scope of the invention is not limited to following implementations
Example.Under the premise of not departing from the invention content of the present invention, the change in this field routine techniques knowledge and means is carried out to it
It all belongs to the scope of protection of the present invention.
Embodiment 1
Influence of the different model polyethylene glycol to gelation temperature
Required reagent：Poloxamer188, PLURONICS F87, polyethylene glycol 2000, Macrogol 4000, polyethylene glycol
6000, water.
The preparation of thermo-sensitive gel agent：Formula ratio poloxamer188 is taken to be added in purified water, stirring is put into 4 DEG C of refrigerator cold-storages
Until complete swelling.Formula ratio PLURONICS F87, polyethylene glycol is added, moisturizing full dose stirs and evenly mixs to get thermo-sensitive gel agent.
The measurement of gelation temperature：It using anastrophe, weighs gel solution and sets in test tube in right amount, then test tube is placed in constant temperature and is added
In pyromagnetic force blender, slowly heating up, heating rate is 1 DEG C/min, tilts test tube by a small margin frequently, when liquid does not flow,
Temperature, that is, gelation temperature.Different polyethylene glycol influence situation to thermo-sensitive gel gelation temperature and are shown in Table 1.
1. different model polyethylene glycol of table influences result to gelation temperature
Embodiment 2
Influence of the thermo-sensitive gel composition ratio to gelation temperature
Thermo-sensitive gel is prepared according to 2 formula ratio of table：Formula ratio poloxamer188 is taken to be added in purified water, stirring is put into 4 DEG C
Refrigerator cold-storage is until complete swelling.Formula ratio PLURONICS F87, polyethylene glycol is added, moisturizing full dose stirs and evenly mixs to get temperature
Quick gelling agent.
The measurement of gelation temperature：It using anastrophe, weighs gel solution and sets in test tube in right amount, then test tube is placed in constant temperature and is added
In pyromagnetic force blender, slowly heating up, heating rate is 1 DEG C/min, tilts test tube by a small margin frequently, when liquid does not flow,
Temperature, that is, gelation temperature.Thermo-sensitive gel composition ratio influences situation to thermo-sensitive gel gelation temperature and is shown in Table 2.
Table 2:Thermo-sensitive gel composition ratio and its influence result to gelation temperature
Embodiment 3
Using C14H10Cl2NNaO2 as main ingredient, prepares C14H10Cl2NNaO2 thermo-sensitive gel and carry out release in vitro research.
The preparation of C14H10Cl2NNaO2 thermo-sensitive gel：It weighs recipe quantity P407 and appropriate distilled water is added, stirring is put into 4 DEG C of refrigerators
Recipe quantity PLURONICS F87, polyethylene glycol and C14H10Cl2NNaO2, moisturizing full dose is added until complete swelling in refrigeration, and stirring mixes
It is even, polyethylene glycol 2000 is added according to the preparation of table 3 respectively, the gelation temperature of Macrogol 4000, Macrogol 6000 is 32 DEG C,
34 DEG C, 36 DEG C of thermo-sensitive gel.
Table 3：C14H10Cl2NNaO2 thermo-sensitive gel preparation prescription
The measurement of Diclofenac sodium content：The selection of Detection wavelength takes C14H10Cl2NNaO2 reference substance solution, C14H10Cl2NNaO2
Thermo-sensitive gel and blank thermo-sensitive gel are appropriate, are scanned in 200~600nm wave-length coverages.As a result reference substance and C14H10Cl2NNaO2
Thermo-sensitive gel has absorption maximum, blank thermo-sensitive gel noiseless to Diclofenac sodium determination at 276nm wavelength.It is thus determined that
276nm wavelength is most suitable Detection wavelength.
The preparation of standard curve：Precision weighs C14H10Cl2NNaO2 reference substance 25mg, sets in 100mL volumetric flasks, and physiology is added
Saline solution, constant volume shake up, and measure this solution 0.5,1.0,1.5,2.0,2.5,3.0,4.0,5.0,6.0mL and set 50mL respectively
In volumetric flask, in addition stating normal saline solution to scale, shake up, measure the absorbance A of each strength solution, by A measure with
Concentration C is returned, and following standard curve can be obtained：Y=33.6990x+0.0047 (R=0.9998).The result shows that double
The fragrant sour sodium of chlorine detects the mass concentration range of linearity and is：0.0025-0.03mg/mL
The preparation of in vitro pigskin：Pigskin is taken, pig hair is dispelled, scrapes off subcutaneus adipose tissue, keep whole pigskin thickness uniform.It puts
Refrigerator is set to save backup.
Release in vitro research：Penetrating absorption grouping experiments are carried out using Franz diffusion cells, fixed pigskin is in transdermal expansion
Between the diffuser casing and receiving chamber that dissipate instrument, towards receiving chamber on the inside of pigskin, keratoderma makes it closely connect towards diffuser casing
It touches and is covered each by diclofenac sodium gel on two groups of pigskin diffuser casings, the saline injection receiving liquid in receiving chamber, liquid
Face is just contacted with skin inner layer, starts the stirring of magnetic stirrer constant speed and constant temperature, and reception tank volume is 6.5mL, effective diffusingsurface
Product be 2.4cm2. respectively upon administration 2,4,6,8,10,12h samplings set after is per sub-sampling in 10mL measuring bottles and add same volume
Long-pending fresh receiving liquid simultaneously excludes the bubble in receiving chamber in the case where wavelength is 276nm, is zeroed, is measured with physiological saline acceptable solution
Each concentration absorbance calculates the content of C14H10Cl2NNaO2 and calculates accumulation infiltration capacity (Q) as follows；
Cn in formula：The mass concentration (mg/mL) that n-th of point in time sampling measures；V：Receiving chamber's volume (mL)；For
The sum of drug accumulation amount, Ci when sampling：The drug quality concentration (mg/mL) that i-th (i=n-1) a point in time sampling measures；Vi：
Sample volume (mL)；；S is effective transdermal area (cm2)。
The evaluation of release in vitro result：Shown in Fig. 1, Fig. 2, Fig. 3, the prescription of addition different model polyethylene glycol (PEG)
Under any temperature of experiment, transdermal test in vitro amount is higher than not adding the thermo-sensitive gel prescription of PEG, illustrates in thermo-sensitive gel prescription
Middle addition PEG2000, PEG4000 or PEG6000 can improve the transdermal penetration effect of thermo-sensitive gel, double to significantly improve
The bioavilability of the fragrant sour sodium of chlorine.
It can be seen that the present embodiment thermo-sensitive gel can increase drug transdermal efficiency for Western medicine Diclofenac sodium carrier, carry
High-drug-effect.
Embodiment 4
Using bletilla polysaccharide as main ingredient, prepares bletilla polysaccharide thermo-sensitive gel and carry out release in vitro research.
The preparation of bletilla polysaccharide thermo-sensitive gel：It weighs recipe quantity P407 and appropriate distilled water is added, it is cold that stirring is put into 4 DEG C of refrigerators
It hides up to complete swelling, recipe quantity PLURONICS F87, polyethylene glycol and C14H10Cl2NNaO2, moisturizing full dose is added and stirs and evenly mixs,
Polyethylene glycol 2000 is added respectively according to the preparation of table 4, Macrogol 4000, the gelation temperature of Macrogol 6000 is 32 DEG C, 34
DEG C, 36 DEG C of thermo-sensitive gel.
Table 4：Bletilla polysaccharide thermo-sensitive gel preparation prescription
The measurement of bletilla polysaccharide content：The selection of Detection wavelength takes bletilla polysaccharide reference substance solution, bletilla polysaccharide temperature sensitive solidifying
Glue and blank thermo-sensitive gel are appropriate, are scanned in 200~600nm wave-length coverages.As a result reference substance and bletilla polysaccharide thermo-sensitive gel
There are absorption maximum, blank thermo-sensitive gel noiseless to bletilla polysaccharide determination at 490nm wavelength.It is thus determined that 490 wavelength are most
Suitable Detection wavelength.
The preparation of standard curve：Precision measurement glucose standard 0.0,0.1,0.2,0.4,0.5,0.6mL set 15mL examinations
Guan Zhong adds water to 1.0mL respectively, adds 5% phenol solution 1.2mL, after being sufficiently mixed, is rapidly added concentrated sulfuric acid 7.0mL, then
It is sufficiently mixed, is moved in ice-water bath after setting 45 DEG C of water-bath 30min, taken out after placing 30min, its trap is surveyed at 490nm
(A).Trap is returned with concentration, obtaining regression equation is：
A=0.04246C-0.00281 (R=0.9904)
The preparation of in vitro pigskin：Pigskin is taken, pig hair is dispelled, scrapes off subcutaneus adipose tissue, keep whole pigskin thickness uniform.It puts
Refrigerator is set to save backup.
Release in vitro research：Penetrating absorption is carried out using Franz diffusion cells, grouping experiment, fixed pigskin is in transdermal expansion
Between the diffuser casing and receiving chamber that dissipate instrument, towards receiving chamber on the inside of pigskin, keratoderma makes it closely connect towards diffuser casing
It touches.It is covered each by diclofenac sodium gel on two groups of pigskin diffuser casings, the saline injection receiving liquid in receiving chamber, liquid
Face is just contacted with skin inner layer, starts the stirring of magnetic stirrer constant speed and constant temperature, and reception tank volume is 6.5mL, effective diffusingsurface
Product is 2.4cm2.Respectively upon administration 2,4,6,8,10,12h samplings set in 10mL measuring bottles.Same volume is added after per sub-sampling
Long-pending fresh receiving liquid simultaneously excludes the bubble in receiving chamber.It in the case where wavelength is 490nm, is zeroed, is measured with physiological saline acceptable solution
Each concentration absorbance calculates the content of bletilla polysaccharide and calculates accumulation infiltration capacity Q as follows；
Cn in formula：The mass concentration (mg/mL) that n-th of point in time sampling measures；V：Receiving chamber's volume (mL)；For
The sum of drug accumulation amount, Ci when sampling：The drug quality concentration (mg/mL) that i-th (i=n-1) a point in time sampling measures；Vi：
Sample volume (mL)；；S is effective transdermal area (cm2)。
The evaluation of release in vitro result：Shown in Fig. 4, Fig. 5, Fig. 6, prescription the appointing in experiment of addition different model PEG
At a temperature of what, transdermal test in vitro amount is higher than not adding the thermo-sensitive gel prescription of polyethylene glycol, illustrates to add in thermo-sensitive gel prescription
Add PEG2000, PEG4000 or PEG6000, can improve the transdermal penetration effect of thermo-sensitive gel, it is more to significantly improve the bletilla striata
Sugared bioavilability.
It can be seen that：This thermo-sensitive gel can be used as Chinese medicine bletilla polysaccharide carrier, and increased drug release in vitro improves drug
Curative effect.
Technical solution in above-mentioned the embodiment of the present application, at least has the following technical effect that or advantage：
Thermo-sensitive gel agent of the present invention, including following raw material by weight percentage：Thermo-sensitive gel matrix 18%~22%,
Penetration enhancer 1%, remaining is water；The thermo-sensitive gel matrix is poloxamer188 and PLURONICS F87；The infiltration promotees
It is polyethylene glycol into agent.Thermo-sensitive gel agent of the present invention is in the liquid condition flowed at 25 DEG C or less, after being applied to skin,
Medicine-feeding part generation is mutually mutated, and forms gel state, and realization delays drug release, improves bioavilability.It is of the present invention temperature sensitive
Gelling agent can local topical and avoid first close from eliminating and reduce adverse reaction, while being liquid condition in vitro, be easy to be administered,
The medicine-feeding part residence time is long, the sustainable release of drug, in addition, the present invention adds polyethylene glycol as penetration enhancer, can have
Effect improves percutaneous penetration of drugs effect, further increases drug bioavailability.
The above content is described in detail the present invention with generality explanation and specific result of implementation, but at this
On the basis of invention, it can be modified or is improved, this it will be apparent to those skilled in the art that.Therefore, not
It is modified or improved made by the basis of deviation spirit of that invention, belongs to the scope of protection of present invention.
Claims (9)
1. a kind of thermo-sensitive gel agent, it is characterised in that：Including following raw material by weight percentage：Thermo-sensitive gel matrix 18%
~22%, penetration enhancer 1%, remaining is water；The thermo-sensitive gel matrix is poloxamer188 and PLURONICS F87；It is described
Penetration enhancer is polyethylene glycol.
2. thermo-sensitive gel agent according to claim 1, it is characterised in that：The polyethylene glycol be selected from polyethylene glycol 2000,
Macrogol 4000 and Macrogol 6000.
3. thermo-sensitive gel agent according to claim 1, it is characterised in that：The poloxamer188 and PLURONICS F87
Mass ratio is 17：(1-5).
4. thermo-sensitive gel agent according to claim 1 or 3, it is characterised in that：The gelation temperature of the thermo-sensitive gel carrier
It is 31-36 DEG C.
5. the preparation method of thermo-sensitive gel agent as described in claim any one of 1-4, it is characterised in that：Include the following steps：
1) poloxamer188 is added in purified water, stirring is put into refrigerator cold-storage until complete swelling；
2) PLURONICS F87, polyethylene glycol and water are added in through step 1) treated poloxamer188, stirs and evenly mixs, i.e.,
Obtain thermo-sensitive gel carrier.
6. the preparation method of thermo-sensitive gel agent according to claim 5, it is characterised in that：In the step 1), the refrigerator
Refrigerated storage temperature is 2-5 DEG C.
7. the application of thermo-sensitive gel agent as described in claim any one of 1-4, it is characterised in that：Using the thermo-sensitive gel agent as
The pharmaceutical carrier of Chinese medicine and Western medicine.
8. the application of thermo-sensitive gel agent according to claim 7, it is characterised in that：The application process includes：
1) poloxamer188 is added in purified water, stirring is put into refrigerator cold-storage until complete swelling；
2) be added in through step 1) treated poloxamer188 PLURONICS F87, polyethylene glycol and and drug, moisturizing it is complete
Amount, stirs and evenly mixs.
9. the application of thermo-sensitive gel agent according to claim 7, it is characterised in that：The drug is selected from Western medicine C14H10Cl2NNaO2
With Chinese medicine bletilla polysaccharide.
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| CN111000794A (en) * | 2019-12-20 | 2020-04-14 | 湖北医药学院 | Bletilla polysaccharide/bioglass temperature-sensitive gel and preparation method and application thereof |
| CN112870156A (en) * | 2021-03-25 | 2021-06-01 | 深圳前海九华国际投资控股有限公司 | Etoricoxib in-situ gel and preparation method thereof |
| CN113304104A (en) * | 2021-05-11 | 2021-08-27 | 四川大学 | Intelligent temperature-sensitive slow-release gel and preparation method thereof |
| CN114306211A (en) * | 2021-12-29 | 2022-04-12 | 中国药科大学 | Glycyrrhizic acid supermolecule self-assembly temperature-sensitive interpenetrating network gel and preparation method and application thereof |
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Cited By (7)
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|---|---|---|---|---|
| CN111000794A (en) * | 2019-12-20 | 2020-04-14 | 湖北医药学院 | Bletilla polysaccharide/bioglass temperature-sensitive gel and preparation method and application thereof |
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| CN113304104A (en) * | 2021-05-11 | 2021-08-27 | 四川大学 | Intelligent temperature-sensitive slow-release gel and preparation method thereof |
| CN114306211A (en) * | 2021-12-29 | 2022-04-12 | 中国药科大学 | Glycyrrhizic acid supermolecule self-assembly temperature-sensitive interpenetrating network gel and preparation method and application thereof |
| CN114306211B (en) * | 2021-12-29 | 2023-12-22 | 中国药科大学 | Glycyrrhizic acid supermolecule self-assembled temperature-sensitive interpenetrating network gel and preparation method and application thereof |
| CN115025040A (en) * | 2022-06-16 | 2022-09-09 | 湖南迈格生物医药有限责任公司 | Temperature-sensitive gel for relieving dysphagia and sternal pain after eating of patients with esophageal cancer and preparation method thereof |
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