CN108295191A - A kind of acne-removing composition and preparation method thereof inhibiting Propiobacterium - Google Patents
A kind of acne-removing composition and preparation method thereof inhibiting Propiobacterium Download PDFInfo
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Abstract
The present invention relates to drug and cosmetic fields, in particular to a kind of acne-removing composition inhibiting Propiobacterium and preparation method thereof, application.The preparation method of acne-removing composition of Propiobacterium is inhibited to include：Wall material solution is obtained by maltodextrin and lactalbumin are soluble in water, and monoglyceride and sucrose ester homogeneous is added；The tea tree ethereal oil and thyme essential oil homogeneous that mass ratio is is added, is dried to obtain active matter；Mix following components：Active matter, tribulus fruit extract, bletilla striata extract, apricot kernel oil, Rhizoma Atractylodis Macrocephalae extract, Semen Nelumbinis extract and honey.The active constituent of tea tree ethereal oil and thyme essential oil plays the effect of best inhibition Propiobacterium.Tea tree ethereal oil is main component with thyme essential oil, the active constituent of tea tree ethereal oil and thyme essential oil is wrapped up by wall material, maximizes retentive activity component, is auxiliary with extracts such as Rhizoma Atractylodis Macrocephalae, puncture vines, it complements each other, it being capable of antibacterial, beauty treatment, inhibition Propiobacterium.
Description
Technical field
The present invention relates to drugs and skin care field, in particular to a kind of acne-removing composition inhibiting Propiobacterium
And preparation method thereof.
Background technology
The generation of acne mainly blocks with hypersteatosis, pilosebaceous duct, bacterium infection and inflammatory reaction etc.
Factor is closely related.Adolesce androgen especially testosterone in descendant's body level it is rapid increase, promote sebaceous glands development
And generate a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage, dyssebacia to form cutin simultaneously
Bolt, that is, micro mist thorn.Multiple-microorganism especially Propiobacterium mass propagation in hair follicle, the lipase that Propiobacterium generates decompose sebum
Free fatty, while chemotactic inflammatory cell and medium are generated, inflammatory reaction is finally induced and aggravate, forms acne.
Propiobacterium (Propionibacterium acnes) is also referred to as propionibacterium acnes, Propionibacterium, is a kind of
Gram-positive anaerobic bacterium is the main bacteria for causing whelk, inhibits the growth of Propiobacterium or kills Propiobacterium, is mesh
A kind of important means of preceding treatment acne.
Skin disease caused by general treatment Propiobacterium, mainly by antibiotic such as erythromycin, metronidazole treatment,
Or by taking two or more merging drug therapies.But antibiotic is excessively used, antibiotic resistant or other may be caused
Side effect.
Invention content
The purpose of the present invention is to provide a kind of acne-removing compositions and preparation method thereof inhibiting Propiobacterium, are intended to carry
For a kind of acne-removing composition of the inhibition Propiobacterium of mild, the low stimulation of ingredient.
The present invention provides a kind of technical solution：
A kind of preparation method of the acne-removing composition of inhibition Propiobacterium, inhibits the preparation of the acne-removing composition of Propiobacterium
Method includes mainly：
It is 1 by mass ratio:The maltodextrin and lactalbumin of 1-3, which is dissolved in 60-80 DEG C of water, obtains wall material solution, Xiang Bi
It is 1 that mass ratio is added in material solution:The monoglyceride and sucrose ester homogeneous of 1-2 obtains the first mixture；Add into the first mixture
It is 1 to enter mass ratio:The tea tree ethereal oil of 1-3 obtains the second mixture with thyme essential oil homogeneous；Second mixture is dried to obtain
Active matter；
Mix the following components counted in parts by weight：
1-15 parts of active matter, 0.5-5 parts of tribulus fruit extract, 0.5-10 parts of bletilla striata extract, 1-25 parts of almond
Oil, 0.5-5 parts of Rhizoma Atractylodis Macrocephalae extract, 0.5-5 parts of Semen Nelumbinis extract and 0.5-5 parts of honey.
The present invention also provides a kind of technical solutions：
A kind of acne-removing composition inhibiting Propiobacterium, inhibits the acne-removing composition of Propiobacterium by above-mentioned inhibition acne
The preparation method of the acne-removing composition of bacillus is prepared.
It is provided in an embodiment of the present invention to inhibit the advantageous effect of the acne-removing composition and preparation method thereof of Propiobacterium to be：
Active matter is prepared in tea tree ethereal oil and thyme essential oil, avoid the activity of tea tree ethereal oil and thyme essential oil at
The volatile problem of partial volume locks the active constituent of tea tree ethereal oil and thyme essential oil, the activity of active constituent is made to obtain maximum
Change and retain, just plays the effect of best inhibition Propiobacterium in use.Based on tea tree ethereal oil and thyme essential oil
Want ingredient, the active constituent of tea tree ethereal oil and thyme essential oil is wrapped up by wall material, retentive activity component is maximized, with white
The extracts such as art, puncture vine are auxiliary, are complemented each other, being capable of antibacterial, beauty treatment, inhibition Propiobacterium.
Specific implementation mode
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
Below specifically to acne-removing composition of inhibition Propiobacterium of the embodiment of the present invention and preparation method thereof, using progress
Explanation.
It should be noted that in an embodiment of the present invention, " active matter ", " the first mixture ", " the second mixture " etc.
Only for distinguishing each component or composition, without other particular meanings.
A kind of preparation method of the acne-removing composition of inhibition Propiobacterium, inhibits the preparation of the acne-removing composition of Propiobacterium
Method includes mainly：
It is 1 by mass ratio:The maltodextrin and lactalbumin of 1-3, which is dissolved in 60-80 DEG C of water, obtains wall material solution, Xiang Bi
It is 1 that mass ratio is added in material solution:The monoglyceride and sucrose ester homogeneous of 1-2 obtains the first mixture；Add into the first mixture
It is 1 to enter mass ratio:The tea tree ethereal oil of 1-3 obtains the second mixture with thyme essential oil homogeneous；Second mixture is dried to obtain
Active matter；
Mix the following components counted in parts by weight：
1-15 parts of active matter, 0.5-5 parts of tribulus fruit extract, 0.5-10 parts of bletilla striata extract, 1-25 parts of almond
Oil, 0.5-5 parts of Rhizoma Atractylodis Macrocephalae extract, 0.5-5 parts of Semen Nelumbinis extract and 0.5-5 parts of honey.
Tea tree ethereal oil is the extract of tea tree.With bactericidal antiphlogistic, convergence pore, treatment cold, cough, rhinitis,
Asthma improves dysmenorrhoea, irregular menstruation and genital infection and other effects.Suitable for oiliness and acne-prone skin, treat suppurative wound and
It burns, tan severely, athlete's foot and dandruff.
Research finds that tea tree ethereal oil has a preferable antibacterial action, and the wherein smaller ingredient of polarity mainly inhibits fungi, and pole
The relatively large ingredient of property mainly inhibits bacterium, to bacillus anthracis, hemolytic streptococcus, Diplococcus pneumopniae, staphylococcus, withered grass
The gram positive bacterias such as bacillus have inhibiting effect to gram negative bacillis such as Escherichia coli and comma bacillus.
Thyme essential oil can antibacterial, antiviral, effectively inhibit dandruff and shave one's head, treatment flu, cough gargle and have a sore throat.It is fragrant
The main component of essential oil is thymol, linalool, fragrant chaste tree nationality phenol, borneol, linalool, nopinene, cloves hydrocarbon etc., is strongest
One of antiseptic can accelerate recovery from illness for acne, eczema or other skin diseases.
In the present embodiment, tea tree ethereal oil and thyme essential oil are obtained into active matter by above-mentioned preparation process, avoided
The readily volatilized problem of the active constituent of tea tree ethereal oil and thyme essential oil, lock the activity of tea tree ethereal oil and thyme essential oil at
Point, make the activity of active constituent obtain maximizing reservation, just plays the effect of best inhibition Propiobacterium in use
Fruit.
Puncture vine, which has, to be adjusted blood fat, adjusts internal micronutrient levels, antibacterial analgesia, and rubella itch can be treated.
The bletilla striata, also known as mutually leaf Lindley Butterflybush Herb (scientific name：Buddleja alternifolia Maxim), the bletilla striata spits for hemoptysis
Blood, traumatic hemorrhage, sore swollen toxin, chapped skin.
Apricot kernel oil, micro- Huang is transparent, fragrant taste, fine rich in protein, unsaturated fatty acid, vitamin, inorganic salts, diet
The trace element of dimension and needed by human body, has the function of moistening lung, stomach invigorating, regains one's strength of body, and amygdalin is even more natural anticancer
Active material.It can effectively mitigate skin people and itch phenomenon, eliminate redness, dryness and inflammation.The brain of internal system can be stimulated
Sagging gland, thymus gland and adrenal gland promote cell turnover.
Apricot kernel oil can make skin restore smooth soft and fine, meet if being used for a long time and can effectively eliminate gestation.Due to sweet tea
Apricot kernel oil is extremely mild, therefore connects baby and can use, further for the myalgia that hyperkinesia causes, if with dessert almond
Oil massage can reinforce cell band oxygen function, and dispelling fatigue is accumulated with carbonic acid, has analgesia and abirritant effect.
Rhizoma Atractylodis Macrocephalae has not typhoid bacillus, paratyphoid bacillus A, shigella flexneri, Escherichia coli, Pseudomonas aeruginosa etc.
With the bacteriostasis of degree.
Lotus seeds have the effect of tonifying spleen and stopping diarrhea, stop-band, the puckery essence of kidney-nourishing, mental-tranquilization.It is usually used in splenasthenic diarrhea, under, loses
Essence, palpitation and insomnia.
Honey has convergence, nutrition to the surface of a wound and promotes Healing, there is lubricity eliminating the phlegm and laxative effective.Tea tree ethereal oil with
Thyme essential oil is main component, and the active constituent of tea tree ethereal oil and thyme essential oil is wrapped up by wall material, maximizes and protects
Active component is stayed, is auxiliary with extracts such as Rhizoma Atractylodis Macrocephalae, puncture vines, complements each other, it being capable of antibacterial, beauty treatment, inhibition Propiobacterium.
It should be noted that in the present embodiment, tribulus fruit extract, bletilla striata extract, Rhizoma Atractylodis Macrocephalae extract, Semen Nelumbinis extract
It is water extract.For example, puncture vine is added to the water, 3-5 hour of boiling, then evaporation drying.
It is understood that in other embodiments of the invention, above-mentioned tribulus fruit extract, bletilla striata extract, Rhizoma Atractylodis Macrocephalae
Extract, Semen Nelumbinis extract may be alcohol extract, for example, by the ethanol water of puncture vine and 60-75vol% at 75-80 DEG C
Lower alcohol extracting 3-5 hours is recycled ethyl alcohol, is then dried.
Further, in other embodiments of the invention, above-mentioned each component is mixed according to following parts by weight：
5-9 parts of active matter, 1-3 parts of tribulus fruit extract, 1-5 parts of bletilla striata extract, 1-5 parts of apricot kernel oil, 1-3
The Rhizoma Atractylodis Macrocephalae extract, 1-3 parts of Semen Nelumbinis extract and 0.5-1.5 parts of honey of part.
The acne-removing composition of inhibition Propiobacterium under said ratio is to inhibiting the better of Propiobacterium.
Further, in an embodiment of the present invention, during preparing active matter, maltodextrin and lactalbumin
The ratio between gross mass and the gross mass of water are 1:1-3.By adjusting the proportioning of maltodextrin and lactalbumin and water, to adjust wall
The concentration of each component in material solution enables the active component of tea tree ethereal oil and thyme essential oil preferably to be lockked.Make tea
The embedding rate for setting essential oil and thyme essential oil is 92.6%.
Further, in an embodiment of the present invention, monoglyceride and the quality summation of sucrose ester and the quality of wall material solution
Than being 1:1-4.Further, in an embodiment of the present invention, tea tree ethereal oil is mixed with the gross mass of thyme essential oil with first
The mass ratio of object is 0.1-0.3:1.It is 94.5% to make the embedding rate of tea tree ethereal oil and thyme essential oil.
The ratio of tea tree ethereal oil and thyme essential oil and the first mixture is adjusted, is adjusted in active matter in tea tree ethereal oil and hundred
The content of essential oil makes the active ingredient of tea tree ethereal oil and thyme essential oil in active matter be fully used.
Further, the volume in this present embodiment, it is 1 that mass ratio is added into first mixture:The tea of 1-3
Tree essential oil obtains second mixture with the thyme essential oil homogeneous, specifically includes：
It is 1 that mass ratio is added into first mixture:The tea tree ethereal oil of 1-3 and the thyme essential oil, in
It is passed through homogenizer after 10000-15000r/min high-speed stirreds 8-12min, the homogeneous 2-5 under 70-80 DEG C and pressure 30-50MPa
It is secondary.
By above-mentioned homogeneous manner, tea tree ethereal oil is made to be sufficiently mixed with the thyme essential oil and the first mixture, the
Intermolecular active force locks tea tree ethereal oil and thyme essential oil molecule in one mixture, avoids tea tree ethereal oil and thyme essential oil
The volatilization of molecule.It is 95.3% to make the embedding rate of tea tree ethereal oil and thyme essential oil.
In the present embodiment, in inlet temperature is 150-200 DEG C, outlet temperature is 80-120 DEG C, atomizing pressure 0.2-
Second mixture is spray-dried to obtain the active matter under conditions of 0.5MPa.
The second mixture is dried using spray drying, the selection to inlet temperature, outlet temperature, the excessively high meeting of temperature
The volatilization of tea tree ethereal oil and thyme essential oil molecule is caused even to be decomposed, temperature is too low, cannot form the parcel-like of microcapsules
State makes tea tree ethereal oil that cannot be wrapped up well with thyme essential oil molecule.
In other embodiments of the invention, mixed active object, tribulus fruit extract, bletilla striata extract, apricot kernel oil, Rhizoma Atractylodis Macrocephalae carry
It takes object, Semen Nelumbinis extract and honey to obtain third mixture later, further includes：
Emulsifier, emollient, moisturizer, essence and preservative, homogeneous are added into third mixture；Wherein, third
Mixture accounts for the 1-15% of third mixture, emulsifier, emollient, moisturizer, essence and preservative gross mass.
Further, it is poly- to be selected from cetostearyl alcohol, dimethyl silicone polymer, fatty acid mono glycidol, docosyl alcohol for emulsifier
It is one or more in ether -25, pentaerythritol stearate and stereth -21；
Emollient is one or more in wheat-germ oil, grape seed oil, shea butter and Sweet Almond Oil；
Moisturizer is one or more in sorbierite, glycerine, polyethylene glycol, propylene glycol, xylitol.
In other embodiments of the invention, the acne-removing composition of above-mentioned inhibition Propiobacterium can be made according to demand
At gelling agent, paste, aqua etc..Further, durings being fabricated to gelling agent, paste, aqua etc., above-mentioned inhibition acne bar
The acne-removing composition of bacterium accounts for the 1%-15.0% of the mass fractions such as gelling agent, paste, aqua.
The present invention also provides a kind of technical solution, a kind of acne-removing composition inhibiting Propiobacterium, the inhibition Propiobacterium
Acne-removing composition be prepared by the preparation method of the acne-removing composition of above-mentioned inhibition Propiobacterium.
The acne-removing composition provided in an embodiment of the present invention for inhibiting Propiobacterium passes through active matter and tribulus fruit extract, lotus
Seed extract etc. mutually assists, and can achieve the purpose that Propiobacterium, and anti-acne is efficient, ingredient is mild, low stimulation.Active matter
Preparation method solves that active constituent is readily volatilized, and active constituent can cause the unstable of cosmetics regular dosage form, cause
The problem of discoloration, layering.
The effect of best inhibition Propiobacterium is just played during active matter use.Its product prepared have compared with
The performance of strong and more lasting inhibition Propiobacterium, can effectively inhibit growing for Propiobacterium, can not only solve " whelk " and ask
Topic can also keep skin health, balance skin water oil distribution to improve skin resistance.
The feature and performance of the present invention are described in further detail with reference to embodiments.
In an embodiment of the present invention, the confession of tribulus fruit extract, bletilla striata extract, Rhizoma Atractylodis Macrocephalae extract, 0 Semen Nelumbinis extract
It is Xi'an Ruitian Biotechnology Co., Ltd. to answer quotient.Tea tree ethereal oil is bought with thyme essential oil in Robert's essence and flavoring agent (Beijing)
Co., Ltd.
Embodiment 1
The present embodiment provides a kind of acne-removing composition inhibiting Propiobacterium, the acne-removing composition masters of the inhibition Propiobacterium
It to be made by following steps：
It is 1 by mass ratio:1 maltodextrin and lactalbumin, which is dissolved in 80 DEG C of water, obtains wall material solution, molten to wall material
It is 1 that mass ratio is added in liquid:1 monoglyceride and sucrose ester homogeneous obtains the first mixture；Quality is added into the first mixture
Than being 1:1 tea tree ethereal oil obtains the second mixture with thyme essential oil homogeneous；Activity is obtained to the second mixture microwave drying
Object.
Wherein, the ratio between gross mass of gross mass and water of maltodextrin and lactalbumin is 1:1.Monoglyceride and sucrose ester
The mass ratio of quality summation and wall material solution is 1:1.
In second mixture, the mass ratio of the gross mass of tea tree ethereal oil and thyme essential oil and the first mixture is 0.1:
1。
Following components is taken to be mixed.
The active matter of 1g, the tribulus fruit extract of 0.5g, the bletilla striata extract of 0.5g, the apricot kernel oil of 1g, 0.5g Rhizoma Atractylodis Macrocephalae carry
Take the honey of object, the Semen Nelumbinis extract of 0.5g and 0.5g.
Tribulus fruit extract, bletilla striata extract, Rhizoma Atractylodis Macrocephalae extract, Semen Nelumbinis extract are water extract.
Embodiment 2
The present embodiment provides a kind of acne-removing composition inhibiting Propiobacterium, the acne-removing composition masters of the inhibition Propiobacterium
It to be made by following steps：
It is 1 by mass ratio:3 maltodextrin and lactalbumin, which is dissolved in 80 DEG C of water, obtains wall material solution, molten to wall material
It is 1 that mass ratio is added in liquid:2 monoglyceride and sucrose ester homogeneous obtains the first mixture；Quality is added into the first mixture
Than being 1:3 tea tree ethereal oil obtains the second mixture with thyme essential oil homogeneous；Second mixture is dried in vacuo to obtain activity
Object.
Wherein, the ratio between gross mass of gross mass and water of maltodextrin and lactalbumin is 1:3.Monoglyceride and sucrose ester
The mass ratio of quality summation and wall material solution is 1:1.
In second mixture, the mass ratio of the gross mass of tea tree ethereal oil and thyme essential oil and the first mixture is 0.3:
1。
Following components is taken to be mixed.
The Rhizoma Atractylodis Macrocephalae extraction of the active matter of 15g, the tribulus fruit extract of 3g, the bletilla striata extract of 10g, the apricot kernel oil of 25g, 5g
The honey of object, the Semen Nelumbinis extract of 5g and 5g.
Tribulus fruit extract, bletilla striata extract, Rhizoma Atractylodis Macrocephalae extract, Semen Nelumbinis extract are alcohol extract.
Embodiment 3
The present embodiment provides a kind of acne-removing composition inhibiting Propiobacterium, the acne-removing composition masters of the inhibition Propiobacterium
It to be made by following steps：
It is 1 by mass ratio:2 maltodextrin and lactalbumin, which is dissolved in 70 DEG C of water, obtains wall material solution, molten to wall material
It is 1 that mass ratio is added in liquid:1.5 monoglyceride and sucrose ester homogeneous obtains the first mixture；Matter is added into the first mixture
Amount is than being 1:2 tea tree ethereal oil and thyme essential oil is passed through homogenizer, 80 after 10000000r/min high-speed stirreds 12min
DEG C and pressure 50MPa under homogeneous 2 times.
It is mixed to second under conditions of inlet temperature is 200 DEG C, outlet temperature is 120 DEG C, atomizing pressure is 0.5MPa
Object is spray-dried to obtain active matter.
Wherein, the ratio between gross mass of gross mass and water of maltodextrin and lactalbumin is 1:2.
In second mixture, the mass ratio of the gross mass of tea tree ethereal oil and thyme essential oil and the first mixture is 0.2:
1。
Following components is taken to be mixed.
The active matter of 5g, the tribulus fruit extract of 2g, the bletilla striata extract of 4g, the apricot kernel oil of 4g, the Rhizoma Atractylodis Macrocephalae extract of 2g, 2g
Semen Nelumbinis extract and 0.9g honey.
Tribulus fruit extract, bletilla striata extract, Rhizoma Atractylodis Macrocephalae extract, Semen Nelumbinis extract are alcohol extract.
Embodiment 4
The present embodiment provides a kind of acne-removing composition inhibiting Propiobacterium, the acne-removing composition masters of the inhibition Propiobacterium
It to be made by following steps：
It is 1 by mass ratio:2 maltodextrin and lactalbumin, which is dissolved in 70 DEG C of water, obtains wall material solution, molten to wall material
It is 1 that mass ratio is added in liquid:1.5 monoglyceride and sucrose ester homogeneous obtains the first mixture；Matter is added into the first mixture
Amount is than being 1:2 tea tree ethereal oil and thyme essential oil is passed through homogenizer, in 70-80 after 15000r/min high-speed stirreds 11min
DEG C and pressure 40MPa under homogeneous 3 times.
To the second mixture under conditions of inlet temperature is 150 DEG C, outlet temperature is 80 DEG C, atomizing pressure is 0.2MPa
Spray drying obtains active matter.
Wherein, the ratio between gross mass of gross mass and water of maltodextrin and lactalbumin is 1:2.
In second mixture, the mass ratio of the gross mass of tea tree ethereal oil and thyme essential oil and the first mixture is 0.2:
1。
Following components is taken to be mixed.
The active matter of 8-9g, the tribulus fruit extract of 2g, the bletilla striata extract of 3g, the apricot kernel oil of 3g, 2g Rhizoma Atractylodis Macrocephalae extract,
The Semen Nelumbinis extract of 2g and the honey of 1.0g.
Tribulus fruit extract, bletilla striata extract, Rhizoma Atractylodis Macrocephalae extract, Semen Nelumbinis extract are alcohol extract.
Embodiment 5
The present embodiment provides a kind of acne-removing composition inhibiting Propiobacterium, the acne-removing composition masters of the inhibition Propiobacterium
It to be made by following steps：
It is 1 by mass ratio:2 maltodextrin and lactalbumin, which is dissolved in 70 DEG C of water, obtains wall material solution, molten to wall material
It is 1 that mass ratio is added in liquid:1.6 monoglyceride and sucrose ester homogeneous obtains the first mixture；Matter is added into the first mixture
Amount is than being 1:2 tea tree ethereal oil and thyme essential oil is passed through homogenizer, at 70 DEG C after 15000r/min high-speed stirreds 10min
With homogeneous 5 times under pressure 40MPa.
To the second mixture under conditions of inlet temperature is 200 DEG C, outlet temperature is 80 DEG C, atomizing pressure is 0.2MPa
Spray drying obtains active matter.
Wherein, the ratio between gross mass of gross mass and water of maltodextrin and lactalbumin is 1:2.
In second mixture, the mass ratio of the gross mass of tea tree ethereal oil and thyme essential oil and the first mixture is 0.2:
1。
Following components is taken to be mixed.
The active matter of 7g, the tribulus fruit extract of 2g, the bletilla striata extract of 3g, the apricot kernel oil of 3g, 2g Rhizoma Atractylodis Macrocephalae extract,
The Semen Nelumbinis extract of 2g and the honey of 0.9g.
Tribulus fruit extract, bletilla striata extract, Rhizoma Atractylodis Macrocephalae extract, Semen Nelumbinis extract are alcohol extract.
Embodiment 6
The present embodiment provides a kind of acne-removing composition inhibiting Propiobacterium, the acne-removing composition masters of the inhibition Propiobacterium
It to be made by following steps：
Example 1 be prepared inhibition Propiobacterium acne-removing composition, be added emulsifier, emollient, moisturizer,
Essence and preservative, homogeneous；Wherein, the acne-removing composition for the inhibition Propiobacterium that embodiment 1 is prepared accounts for gross mass
1-15%.
Emulsifier is cetostearyl alcohol, dimethyl silicone polymer, fatty acid mono glycidol and stereth -21；
Emollient is wheat-germ oil, grape seed oil, shea butter and Sweet Almond Oil；
Moisturizer is sorbierite, glycerine, polyethylene glycol and propylene glycol.
Test example 1
The acne-removing composition for the inhibition Propiobacterium that the embodiment of the present invention 1 is prepared is in clinical observation on the therapeutic effect
Diagnostic criteria
Western medicine diagnostic criteria
With reference to Chinese Medical Association's version《One skin disease of clinic diagnosis guide and venereal disease fascicle》Acne diagnostic criteria patient is young
Men and women betides the seborrheas such as face and shirtfront back position, there is acne, papule, fester and tubercle, the skin lesions such as tumour.
Tcm diagnosis standard
With reference to People's Health Publisher's version《Modern Chinese medicine Merck Manual series skin venereal disease handbook》Acne lesions from the beginning of for
Pinhead-sized pityriasis rubra papule, or be Whiteheads, blackhead, extrudable white or faint yellow fat bolt, shape due to infection
At red small papule, top may occur in which small purulence lump.Feel slight itch or no conscious sympton, self-induction pain when inflammation is apparent.
Exclusion criteria：
1. not meeting this research traditional Chinese and western medicine diagnosis person；
2. allergic constitution or to this medicine and drug ingedient allergy sufferers；
3. gestation or women breast-feeding their children；
4. used in the next few days with the relevant medicine for oral administration of this disease, used in the day and relevant external used medicine person of this disease；
5. merge intentionally, the cerebrovascular, liver, ' the severe primaries disease such as kidney and hemopoietic system, mental patient；
6. secondary acne, acne conglobata, acne fulminans, occupational acne, drug-induced patients with acne and bad
Dead property patients with acne；
7. suffering from other face dermatosis that may influence experimental observation, such as lupus erythematosus, allergic dermatitis, psoriasis
Deng.
Therapy
Face is cleaned with warm water, then the acne-removing composition for the inhibition Propiobacterium being prepared with embodiment 1 is applied to skin
At damage, all patients treat 1 time every night, the course for the treatment of 4 weeks, carry out follow-up within 4 months after patient cures.
Curative effect index：
According to pretherapy and post-treatment skin lesion number, therapeutic index, the influence of observation test group, control group to skin lesion are calculated.
Skin lesion number × 100% before skin lesion number/treatment after skin lesion number-treatment before therapeutic index=treatment.
Curative effect determinate standard：
What reference year month Chinese Medical Association's aesthetics and beauty branch beautifying skin group were formulated《Acne vulgaris severity point
Grade and curative effect determinate standard》Carry out therapeutic evaluation.Recovery from illness skin lesion is subsided substantially, and pain of itching disappears, and the effective skin lesion of therapeutic index is bright
Aobvious to subside, pain of itching is substantially reduced, and therapeutic index is that an effective skin lesion is subsided, and pain of itching mitigates, and therapeutic index is part nothing
It imitates skin lesion and subsides seldom or skin lesion without substantially changeing or aggravating, pain of itching does not mitigate or aggravates, therapeutic index.Total effective rate is
The ratio of the sum of recovery from illness, effective, effective number of cases with total case load.
Result of study：
Total effects are analyzed
In 50 patients, clinical cure 15, effective 22, effective 13, invalid 0, total effective rate 100% is controlled
More patient's follow-up after 4 months.No relapse, since acne easily recurs, the present invention is made of optimum feed stock, can thoroughly be cured,
Easily recurrence achieves obviously technological progress compared with prior art.It the results are shown in Table 1.
The effect of acne-removing composition for the inhibition Propiobacterium that 1 embodiment 1 of table is prepared
Note：Compared with the control group, * P ＜ 0.05
Have no adverse reaction appearance in treatment group's therapeutic process.
Test example 2
Correspondingly, with reference to test example 1, the anti-acne combination to the inhibition Propiobacterium that embodiment 1- embodiments 6 are prepared
The effect of acne caused by object progress Propiobacterium, is assessed.It the results are shown in Table 2.
The effect of acne-removing composition for the inhibition Propiobacterium that 2 embodiment 1-6 of table is prepared
Illustrate that the acne-removing composition for the inhibition Propiobacterium that embodiment 1- embodiments 6 are prepared can treat Propiobacterium
Caused acne, cure rate are higher.
Test example 3
Propiobacterium bacteriostasis property is assessed
One, equipment
1, test strain：Propionibacterium acnes (ATCC 11827), are provided by China General Microbiological Culture Collection Center.
2, sample：The acne-removing composition for the inhibition Propiobacterium that embodiment 1 is prepared.
3, timer and measuring pipette (1.0ml, 5.0ml, 10.0ml) etc..
Two, operating procedure
By test organisms, slant culture is washed down with PBS for 24 hours, be made bacteria suspension (it is required that it is a concentration of:With 100 μ L drops in right
In the same old way on piece or 5mL sample liquids, bacterial count recovered is 1 × 104~9 × 104cfu/ pieces or mL).
It takes and (with sample homogeneous material, same size, but is free of anti-biotic material by test liquid (5mL) and control sample liquid, and is passed through
Sterilization treatment) it is each 4 pipe.
Above-mentioned bacteria suspension is taken, respectively each by test liquid and control sample liquid or 100 μ L of interior dropwise addition, even spread.It opens
Beginning timing, effect 2,5,10,20min are respectively thrown sample liquid (0.5mL) in test tube of the people containing 5mLPBS with sterile tweezer, fully mixed
It is even, make appropriate dilution, then takes wherein 2~3 dilutions, draw 0.5mL respectively, be placed in two plates, with cool to 40~45
DEG C nutrient agar (bacterium) or sabouraud's agar (liquor-saturated mother bacterium) 15mL pour into, rotate plate, keep it abundant
Uniformly, tablet, 35 DEG C of scholars, 2 DEG C of culture 48h (bacterium) or 72h (saccharomycete) are overturn after agar solidification, make the counting of viable bacteria bacterium colony.
Experiment is repeated 3 times, and bacteriostasis rate is calculated as follows：
X=(A-B)/A × 100%
In formula：X --- bacteriostasis rate, %；
A --- control sample average colony number；
B --- subject sample average clump count.
2, evaluation criterion
Bacteriostasis rate >=50%-90%, product have bacteriostasis, bacteriostasis rate >=90%, product to have stronger bacteriostasis.
Three, experimental result
Experimental result is shown in Table 3.
The drug that 3 embodiment 1 of table is prepared assesses Propiobacterium bacteriostasis property
Illustrate that the acne-removing composition for the inhibition Propiobacterium that the embodiment of the present invention 1 provides can inhibit Propiobacterium antibacterial,
Bacteriostasis rate is up to 99.9%.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, any made by repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of preparation method of the acne-removing composition of inhibition Propiobacterium, which is characterized in that described to inhibit dispelling for Propiobacterium
The preparation method of acne composition includes mainly：
It is 1 by mass ratio:The maltodextrin and lactalbumin of 1-3, which is dissolved in 60-80 DEG C of water, obtains wall material solution, to the wall
It is 1 that mass ratio is added in material solution:The monoglyceride and sucrose ester homogeneous of 1-2 obtains the first mixture；To first mixture
Middle addition mass ratio is 1:The tea tree ethereal oil of 1-3 obtains the second mixture with thyme essential oil homogeneous；To second mixture
It is dried to obtain active matter；
Mix the following components counted in parts by weight：
1-15 parts of the active matter, 0.5-5 parts of tribulus fruit extract, 0.5-10 parts of bletilla striata extract, 1-25 parts of almond
Oil, 0.5-5 parts of Rhizoma Atractylodis Macrocephalae extract, 0.5-5 parts of Semen Nelumbinis extract and 0.5-5 parts of honey.
2. the preparation method of the acne-removing composition of inhibition Propiobacterium according to claim 1, which is characterized in that mixing is pressed
The following components of parts by weight meter：
5-9 parts of the active matter, 1-3 parts of the tribulus fruit extract, 1-5 parts of the bletilla striata extract, 1-5 parts described
Apricot kernel oil, 1-3 parts of the Rhizoma Atractylodis Macrocephalae extract, 1-3 parts of the Semen Nelumbinis extract and 0.5-1.5 parts of the honey.
3. the preparation method of the acne-removing composition of inhibition Propiobacterium according to claim 1, which is characterized in that the wheat
The ratio between the gross mass of bud dextrin and the lactalbumin and the gross mass of the water are 1:1-3.
4. the preparation method of the acne-removing composition according to claim 1 for inhibiting Propiobacterium, which is characterized in that described the
In two mixtures, the gross mass and the mass ratio of first mixture of the tea tree ethereal oil and the thyme essential oil are
0.1-0.3:1。
5. the preparation method of the acne-removing composition according to claim 1 for inhibiting Propiobacterium, which is characterized in that described
It is 1 that mass ratio is added in first mixture:The tea tree ethereal oil of 1-3 obtains described second with the thyme essential oil homogeneous and mixes
Object is closed, is specifically included：
It is 1 that mass ratio is added into first mixture:The tea tree ethereal oil of 1-3 and the thyme essential oil, in
It is passed through homogenizer after 10000-15000r/min high-speed stirreds 8-12min, the homogeneous 2-5 under 70-80 DEG C and pressure 30-50MPa
It is secondary.
6. the preparation method of the acne-removing composition of inhibition Propiobacterium according to claim 1, which is characterized in that described
Second mixture is dried to obtain the active matter, specifically includes：In inlet temperature be 150-200 DEG C, outlet temperature 80-120
DEG C, atomizing pressure be 0.2-0.5MPa under conditions of second mixture is spray-dried to obtain the active matter.
7. the preparation method of the acne-removing composition of inhibition Propiobacterium according to claim 1, which is characterized in that mixing institute
State active matter, the tribulus fruit extract, the bletilla striata extract, the apricot kernel oil, the Rhizoma Atractylodis Macrocephalae extract, lotus seeds extraction
Third mixture is obtained after object and the honey, further includes：
Emulsifier, emollient, moisturizer, essence and preservative, homogeneous are added into the third mixture；Wherein, described
Third mixture accounts for the third mixture, the emulsifier, the emollient, the moisturizer, the essence and described
The 1-15% of preservative gross mass.
8. the preparation method of the acne-removing composition of inhibition Propiobacterium according to claim 7, which is characterized in that
The emulsifier is selected from cetostearyl alcohol, dimethyl silicone polymer, fatty acid mono glycidol, docosyl alcohol polyethers -25, season penta
It is one or more in tetrol distearate and stereth -21；
The emollient is one or more in wheat-germ oil, grape seed oil, shea butter and Sweet Almond Oil；
The moisturizer is one or more in sorbierite, glycerine, polyethylene glycol, propylene glycol, xylitol.
9. the preparation method of the acne-removing composition of inhibition Propiobacterium according to claim 1, which is characterized in that the list
The mass ratio of the quality summation of sweet fat and the sucrose ester and the wall material solution is 1:1-4.
10. it is a kind of inhibit Propiobacterium acne-removing composition, which is characterized in that it is described inhibit Propiobacterium acne-removing composition by
Claim 1-8 any one of them inhibits the preparation method of the acne-removing composition of Propiobacterium to be prepared.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110403979A (en) * | 2019-09-03 | 2019-11-05 | 陕西伟荣科创实业有限公司 | A kind of ointment of the treatment acne containing mongollian thyme herb volatile oil |
| CN110420159A (en) * | 2019-05-27 | 2019-11-08 | 广州好蝶化妆品有限公司 | A kind of anti-acne maintenance essence cream and preparation method |
| CN113413356A (en) * | 2021-05-07 | 2021-09-21 | 广州摩亚方舟贸易有限公司 | Peach tocol-based acne-removing composition and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432012A (en) * | 2013-09-09 | 2013-12-11 | 北京振东光明药物研究院有限公司 | Sophocarpidine micro emulsion as well as preparation method thereof and application of micro emulsion in liquid soap |
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2018
- 2018-04-08 CN CN201810308093.2A patent/CN108295191A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432012A (en) * | 2013-09-09 | 2013-12-11 | 北京振东光明药物研究院有限公司 | Sophocarpidine micro emulsion as well as preparation method thereof and application of micro emulsion in liquid soap |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110420159A (en) * | 2019-05-27 | 2019-11-08 | 广州好蝶化妆品有限公司 | A kind of anti-acne maintenance essence cream and preparation method |
| CN110403979A (en) * | 2019-09-03 | 2019-11-05 | 陕西伟荣科创实业有限公司 | A kind of ointment of the treatment acne containing mongollian thyme herb volatile oil |
| CN113413356A (en) * | 2021-05-07 | 2021-09-21 | 广州摩亚方舟贸易有限公司 | Peach tocol-based acne-removing composition and preparation method thereof |
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