CN108272942A - A kind of Chinese medicine composition and its preparation method and application for drug rehabilitation - Google Patents
A kind of Chinese medicine composition and its preparation method and application for drug rehabilitation Download PDFInfo
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- CN108272942A CN108272942A CN201810191300.0A CN201810191300A CN108272942A CN 108272942 A CN108272942 A CN 108272942A CN 201810191300 A CN201810191300 A CN 201810191300A CN 108272942 A CN108272942 A CN 108272942A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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Abstract
The invention belongs to tcm fields, are related to a kind of Chinese medicine composition and its preparation method and application for drug rehabilitation.Specifically, the present invention relates to a kind of Chinese medicine composition for drug rehabilitation, preparation method includes its pharmaceutical preparation, and its purposes in preparing anti-additive medicament.The Chinese medicine composition for drug rehabilitation of the present invention is nontoxic, without side-effects, without sensitization all with plant medicine progress prescription.It is found by clinical research, the Chinese medicine composition for drug rehabilitation of the present invention can give up the drug addiction and heart addiction of the drugs such as heroin, ***e, numb Gu, head-shaking pill, methamphetamine, Ketamine, facial treatment essence in shorter treatment cycle, and the fast quick-recovery body of energy, there is good social value and economic value.
Description
Technical field
The invention belongs to tcm field, it is related to a kind of Chinese medicine composition for drug rehabilitation, preparation method, including its
Pharmaceutical preparation, and its purposes in preparing anti-additive medicament.
Background technology
Drugs refer to opium, heroin, crystal methamphetamine (being commonly called as ice), morphine, hemp, ***e and state's domestic discipline and family rules
Other narcotics and psychotropic substances that can make one to be formed addiction of fixed tube.Commission on Narcotic Drugs (CND) will
Drugs are divided into six major class：1, morphine type drug, including opium, morphine, heroin and creamcups etc.；2, ***e and Ke Ka
Leaf；3, hemp；4, the artificial synthesized excitant such as amphetamine (amphetamine)；5, tranquilizing soporific similar drug, including barbiturates and
Non- barbiturates (such as methaqualone)；6, Psychopathic Drugs, including stable class.
The harm of drug abuse is mainly shown as the following aspects：1) to the harm of body：Consuming illegal drugs can make human body to it
Generate extremely strong dependence, to the vital organs of the human body and brain it is damaging greatly.By taking heroin as an example, habituation is most fast, and toxicity is most
It is strong, once it was referred to as " kings of world's drugs ", the people for persistently sucking heroin is typically only capable to live 7~8 years, and once receives detoxification and control
Treat, just will appear shed tears, runny nose, salivation, abdominal pain, the symptoms such as headache, mend after food that then all symptoms disappear at once, and with extremely
Strong floaty euphoria and illusion.Once addicted, it is difficult to break away from, body and mind is all tired.2) to the harm of family：Once being inhaled in family
Malicious person, then family is just no longer family.Drug addict is also persecuting the family of oneself, it is made to be absorbed in economy while self-destruction
Bankruptcy, the difficult condition that relatives are discrete, even with one's family broken up.3) to the harm of society：Huge damage in addition to causing the wealth of society
It becomes estranged other than waste, drugs can also cause the deterioration of social environment, induce various illegal activities, disturb public order, give
Social stability brings grave danger.Therefore, seek safe and effective anti-additive medicament and method by with important medical value and
Social effect.
Currently, the drug rehabilitation method of mainstream includes following several：1) natural drug withdrawal does not provide special anti-additive medicament,
Hardness stops taking drugs, and allows the withrawal symptom organic growth of drug addict, spontaneous regression, also known as cold turkey.This method is unsuitable for year
The drug addict that age is larger and constitution is weaker, there may come a time when entail dangers to life.2) drug withdrawal method is mitigated using anti-additive medicament
The withrawal symptom of drug addict is successively decreased using other similar drugs (such as methadone, buprenorphine, clonidine) substitute
Property treatment.But anti-additive medicament easy tos produce new additive, and new drugs can be developed into again by controlling not tight or improper use.3)
Non-drug gives up method mitigates the withrawal symptom of drug addict using means such as acupuncture, physiotherapy equipment, psychological consultations.This method
Treatment time is longer, and consolidation is not thorough, and easily causes to relapse.
Chinese invention patent application CN1628819A discloses a kind of scorpion and Chinese goldthread containing pills for drug abstinence, it includes scorpion, coptis root,
The medicinal materials such as dragon, Rhizoma Gastrodiae, unanimous grass, celestial hair, cinnabar, Radix Glycyrrhizae, but due to, there are animal drugs such as scorpion, earthworms, partly being used in prescription
Person may cause allergic reaction, and which limits the application ranges of the drug rehabilitation micelle.Chinese invention patent application
Compound Chinese medicinal preparation disclosed in CN1189376A includes the multi-flavors animal drugs such as centipede, scorpio, Bungarus Parvus, is equally existed
State sensitization risk.Chinese invention patent application CN1195555A discloses a kind of narcotics-giving-up oral liquor, wherein including not only to be easy
The ingredients such as the grain shell of addiction, datura flower, cause drug addiction to further include the rare medicinal herbs such as antelope's horn, Moschus, pilose antler, be produced into easily repeatedly
This is higher.
Invention content
Problems to be solved by the invention
In view of rarely having on the market at present safely, effectively and lower-cost Chinese medicine for giving-up drugging, the present invention provides one kind
For the Chinese medicine composition of drug rehabilitation, preparation method includes its pharmaceutical preparation, and its purposes in preparing anti-additive medicament.
The solution to the problem
On the one hand, the present invention provides it is a kind of for drug rehabilitation Chinese medicine composition, it includes airpotato yam, the fruit of summer cypress, rhizoma alismatis,
Kuh-seng, stir-baked SEMEN ZIZIPHI SPINOSAE and Cortex Eucommiae.
Further, the above-mentioned Chinese medicine composition for drug rehabilitation also includes Fructus Forsythiae, lily, Rhizoma Gastrodiae, the seed of Oriental arborvitae and Radix Astragali.
Further, the above-mentioned Chinese medicine composition for drug rehabilitation also includes honeysuckle, Schisandra chinensis, root of Aucklandia lappa Decne, dried orange peel, Fu
Siberian cocklebur, rheum officinale, profound Hu, Radix Polygalae, ginseng and Radix Angelicae Sinensis.
In parts by weight, the above-mentioned Chinese medicine composition for drug rehabilitation includes 10~30 parts of airpotato yams, 5~15 parts of fruit of summer cypress, 5
~15 portions of rhizoma alismatis, 10~20 parts of kuh-sengs, 20~50 parts of stir-baked SEMEN ZIZIPHI SPINOSAEs and 15~40 parts of Cortex Eucommiaes.
Preferably, in parts by weight, the above-mentioned Chinese medicine composition for drug rehabilitation includes 20 parts of airpotato yams, 10 parts of fruit of summer cypress, 9
Part rhizoma alismatis, 12 parts of kuh-sengs, 30 parts of stir-baked SEMEN ZIZIPHI SPINOSAEs and 25 parts of Cortex Eucommiaes.
Further, in parts by weight, it is above-mentioned for drug rehabilitation Chinese medicine composition include 10~30 parts of Fructus Forsythiaes, 10~20 parts
Lily, 5~20 parts of Rhizoma Gastrodiaes, 5~20 parts of seed of Oriental arborvitaes and 40~80 parts of Radix Astragalis.
Preferably, in parts by weight, it is above-mentioned for drug rehabilitation Chinese medicine composition include 18 parts of Fructus Forsythiaes, 13 portions of lilies, 10 parts
Rhizoma Gastrodiae, 10 parts of seed of Oriental arborvitaes and 60 parts of Radix Astragalis.
Further, in parts by weight, the above-mentioned Chinese medicine composition for drug rehabilitation includes 5~20 parts of honeysuckles, 5~20
Part Schisandra chinensis, 5~15 parts of root of Aucklandia lappa Decne, 5~15 parts of dried orange peels, 5~15 parts of Poria cocos, 5~15 parts of rheum officinales, 15~30 parts of profound Hus, 10~30
Part Radix Polygalae, 20~40 parts of ginsengs and 15~25 parts of Radix Angelicae Sinensis.
Preferably, in parts by weight, the above-mentioned Chinese medicine composition for drug rehabilitation includes 12 portions of honeysuckles, 10 parts of Schisandra chinensis, 8
Part root of Aucklandia lappa Decne, 8 parts of dried orange peels, 9 parts of Poria cocos, 8 parts of rheum officinales, 18 parts of profound Hus, 13 parts of Radix Polygalaes, 30 parts of ginsengs and 20 parts of Radix Angelicae Sinensis.
On the other hand, the present invention provides the preparation methods of the above-mentioned Chinese medicine composition for drug rehabilitation comprising by each taste
The step of medicinal material is weighed and is mixed.
In another aspect, the present invention provides a kind of pharmaceutical preparation, it includes the above-mentioned in drug rehabilitation of therapeutically effective amount
Drug composition and one or more pharmaceutically acceptable carriers.
Further, the pharmaceutically acceptable carrier includes but is not limited to solvent, solubilizer, cosolvent, emulsification
Agent, rectifys olfactory agent, colorant, adhesive, disintegrant, filler, lubricant, wetting agent, osmotic pressure regulator, pH tune at corrigent
Save agent, stabilizer, surfactant, preservative etc..
Further, the pharmaceutical preparation is solid pharmaceutical preparation, semisolid preparation or liquid preparation.
Further, the solid pharmaceutical preparation includes but is not limited to tablet, capsule, granule, powder, sublimed preparation, ingot
Agent, pill etc.；The semisolid preparation includes but is not limited to gelling agent, suppository, paste, paste etc.；The liquid preparation packet
Include (but not limited to) decoction, mixture, suspension, solution etc..
Another aspect, the purposes that the present invention provides above-mentioned for the Chinese medicine composition of drug rehabilitation in preparing anti-additive medicament.
The effect of invention
The Chinese medicine composition for drug rehabilitation of the present invention all carries out prescription, nontoxic, without side-effects, nothing with plant medicine
Sensitization.Found by clinical research, using the present invention for drug rehabilitation Chinese medicine composition in shorter treatment cycle energy
Enough have the function that the drug addiction and heart addiction of giving up the drugs such as heroin, ***e, numb Gu, head-shaking pill, methamphetamine, Ketamine, facial treatment essence,
And it can fast quick-recovery body.Personnel after giving up contact drugs and can be sick in the stomach and detest sense again, will produce ammonia odor in mouth
Road, thus will produce far from drugs, return the hope of family and society.The present invention has good social value and economic valence
Value.
Specific implementation mode
First, the present invention provides a kind of Chinese medicine composition for drug rehabilitation, it includes airpotato yam, the fruit of summer cypress, rhizoma alismatis, hardships
Ginseng, stir-baked SEMEN ZIZIPHI SPINOSAE and Cortex Eucommiae.
In the context of the present invention, term " airpotato yam " refers to Dioscoreaceae perennial root prehensile liana air potato
The stem tuber of (Dioscorea bulbifera L.), main product is in south China various regions.Summer, the excavation of two season of autumn, clean soil, remove
The fibrous root of hairy, slice, is dried.It is raw to use.Airpotato yam is cold in nature, bitter, nontoxic, return lung, Liver Channel, belongs to expectorants, antitussives and anti-asthmatics medicine, uses
In dissipating bind fall fire, clearing heat and detoxicating, cooling blood and hemostasis.
In the context of the present invention, term " fruit of summer cypress " refers to Chenopodiaceae annual herb plant summer cypress (Kochia
Scoparia (L.) Schrad.) ripening fruits.Fruit of summer cypress main product in Hebei, Shanxi, Shandong, Henan and other places, Liaoning, Qinghai,
Also it produces on the ground such as Shaanxi, Sichuan.Herb is extracted when the fruit matures in the fall, is dried, fruit is laid, and removes impurity.It is raw to use.The fruit of summer cypress
Cold, bitter is nontoxic, returns bladder warp, belongs to damp-clearing drug, for clearing away heat and promoting diuresis, relieving sore-throat relieving restlessness, antipruritic.
In the context of the present invention, term " rhizoma alismatis " refers to the perennial limnocryptophyte rhizoma alismatis (Alisma of Alismataceae
Orientale (Sam.) Juzep.) stem tuber.Rhizoma alismatis main product is in Fujian, Sichuan, Jiangxi and other places.When winter cauline leaf starts withered
Excavation is cleaned, and is dried with low baking temperature, then hit fibrous root and bark, is moisturized slice with water, dry.Wheat bran or brine, which are fried, to be used.Rhizoma alismatis property
It is cold, it is sweet in flavor, light, it is nontoxic, return kidney, bladder warp, belongs to damp-clearing drug, for clearing damp and promoting diuresis, expel the heat-evil.
In the context of the present invention, term " kuh-seng " refers to the perennial fallen leaves semishrub plant kuh-seng (Sophora of pulse family
Flavescens Ait.) root.China produces various regions.Spring and autumn is excavated, and except removing LU, fibrous root, is cleaned, and slice dries.
Kuh-seng is cold in nature, bitter, nontoxic, the thoughts of returning home, liver, stomach, large intestine, bladder warp, belong to heat-clearing and damp-drying drug, for heat-clearing and damp-drying drug, wind dispelling insecticide,
Diuresis is antipruritic.
In the context of the present invention, term " jujube kernel " refers to Rhamnaceae deciduous tree wild jujube (Ziziphus jujuba
Mill. mature seed).Jujube kernel main product is in Hebei, Shaanxi, Liaoning, the Inner Mongol, Shandong, Shanxi, Gansu, Henan and other places.Qiu Mo
It is harvested when fruit maturation at the beginning of winter, removes jujube meat, ground and break core, take seed drying.Raw use fries use, in context of the invention
" stir-baked SEMEN ZIZIPHI SPINOSAE " is stir-fry processed product.Stir-baked SEMEN ZIZIPHI SPINOSAE is mild-natured, sweet in flavor, nontoxic, converge to heart and liver channels, belong to sedative, for mental-tranquilization,
Arrest sweating relieving restlessness.
In the context of the present invention, term " Cortex Eucommiae " refers to Eucommiaceae deciduous tree plant Cortex Eucommiae (Eucommia
Ulmoides Oliv.) bark.Cortex Eucommiae main product is in Sichuan, Yunnan, Guizhou, Hubei and other places.Summer and autumn harvest goes appearance thick
Skin dries.Raw use or brine, which are fried, to be used.Cortex Eucommiae is warm-natured, sweet in flavor, nontoxic, returns liver and kidney channel, belongs to yang-tonifying drug, for filling liver kidney, strengthening tendons
Bone, tocolysis.
In a preferred embodiment, the Chinese medicine composition for drug rehabilitation of the invention also includes Fructus Forsythiae, lily, day
Fiber crops, the seed of Oriental arborvitae and Radix Astragali.
In the context of the present invention, term " Fructus Forsythiae " refers to Oleaceae defoliation bush plant Fructus Forsythiae (Forsythia
Suspense (Thunb.) Vahl) fruit.Fructus Forsythiae main product is in China northeast, North China, the Yangtze river basin to Yunnan.Wild, family's kind
Have.Fructus Forsythiae cold nature, bitter is nontoxic, return lung, the heart, gallbladder channel, belongs to heat-clearing and detoxifying drug, for clearing heat and detoxicating, carbuncle that disappears dissipating bind, dissipates
Heat detumescence.
In the context of the present invention, term " lily " refers to Liliaceae herbaceos perennial lily (Lilium
Brownii F.E.Brown var.Colchesteri Wils.) and Lilium tenuifolium (Lilium pumilum DC.) meat
Bulb.It produces all parts of the country.Excavated when autumn cauline leaf is withered, clean, strip scale, boiling water scalded, or slightly steamed, dry or
Drying.Lily cold nature, sweet in flavor, nontoxic, return lung, the heart channel of Hang-Shaoyin belong to yin tonics, for moistening the lung and relieve the cough, clearing away the heart fire and tranquillizing.
In the context of the present invention, term " Rhizoma Gastrodiae " refers to orchid family parasitic herbaceous plant Rhizoma Gastrodiae (Gastrodia for many years
Elata Bl.) stem tuber.Rhizoma Gastrodiae main product is widely distributed in China north and south various regions in Sichuan, Yunnan, Guizhou.Dig after, remove on the ground
Stem and mycelia, wipe crust, clean well-done or cook, flatten, low baking temperature is dried.Used time moisturizes slice.Rhizoma Gastrodiae is mild-natured, sweet in flavor, nothing
Poison, return liver warp belong to medicine for calming liver and calming endopathic wind, for Inflammation Zhijing, wind-expelling pain-stopping, calming the liver.
In the context of the present invention, term " seed of Oriental arborvitae " refers to Cupressaceae aiphyllium plant arbor-vitae (Biota
Orientalis (L.) Endl.) mature seed kernel.Largely there are production, the ground such as main product Shandong, Henan, Hebei in the whole nation.It is after autumn ripe
Shi Caishou is dried, and is removed decapsidate, is dried in the shade.Used time smashes.The seed of Oriental arborvitae is mild-natured, sweet in flavor, nontoxic, the thoughts of returning home, kidney, large intestine channel, belongs to and calming the nerves
Medicine for mental-tranquilization, relaxes bowel.
In the context of the present invention, term " Radix Astragali " refers to leguminous perennial herb Radix Astragali (Astragalus
Membranaceus (Fisch.) Bge.) and Inner Mongolia Astragalis (Astragalus mongholicus Bge.) root.Radix Astragali main product
In Shanxi, Gansu, Heilungkiang, the Inner Mongol and other places；Astragalus mongholicus Bge main product is in the Inner Mongol, Jilin, Hebei, Shanxi and other places.It removes
Aerial part and fibrous root, are dried.Moisturize slice.Raw use or honey system are used.Radix Astragali slightly warm in nature, sweet in flavor, nontoxic, returns spleen, lung channel belong to and mending
Gas medicine, for tonifying Qi and lifting yang, invigorating qi for consolidating superficies, promoting pus discharge and tissue regeneration, profit water detumescence.
In a further preferred embodiment, the Chinese medicine composition for drug rehabilitation of the invention also includes honeysuckle, five
Taste, root of Aucklandia lappa Decne, dried orange peel, Poria cocos, rheum officinale, profound Hu, Radix Polygalae, ginseng and Radix Angelicae Sinensis.
In the context of the present invention, term " honeysuckle " refers to that perennial half evergreen prehensile woody climber of Caprifoliaceae is planted
The bud of object honeysuckle (Lonicera japonica Thunb.).China north and south various regions are distributed.Early summer is when the budding blossoms waiting to burst forth for flower
When pick, dry in the shade.It is raw to use or be made as distillate medicinal water.Honeysuckle is cold in nature, sweet in flavor, nontoxic, return lung, stomach, large intestine channel, belongs to heat-clearing and detoxifying drug,
For clearing heat and detoxicating, relieving sore-throat relieving restlessness.
In the context of the present invention, term " Schisandra chinensis " refers to the perennial fallen leaves bejuco Chinese Magnoliavine of Magnoliaceae
Sub (Schisandra chinesis Baill.) and schisandra chinensis (Schisandra sphenanthera Rehd.et
Wils. ripening fruits).Fructus schisandrae is the certified products that tradition uses, and main product is in northeast, the Inner Mongol, Hebei, Shanxi and other places.China
Middle Schisandra chinensis is produced in southwest and Yangtze river basin areas to the south.It harvests when the fruit matures in the fall, removes fruit juice, dry.It is raw
Steaming, which is mixed, with or through vinegar, honey dries use.Schisandra chinensis is warm-natured, sour, sweet, nontoxic, return lung, kidney, the heart channel of Hang-Shaoyin, belongs to astringent medicinal, is used for clearing lung-heat
Expectoration, the arrest sweating that promotes the production of body fluid, puckery smart antidiarrheal, antitoxic heart-soothing and sedative.
In the context of the present invention, term " root of Aucklandia lappa Decne " refers to composite family herbaceos perennial Aplotaxis auriculata (Saussurea
Lappa Clarke), the root of radix jurineae (Vladimiria souliei (Franch.) Ling).Lijiang, yunnan city person is originated in claim
Aplotaxis auriculata, originates in Sichuan An County, Aba Tibetan Autonomous Prefecture, Yi Autonomous Prefecture of Liangshan person claim radix jurineae, originates in the ground such as India, Burma
Person claims costus root.9~October excavates.It is raw to use or simmer use.Root of Aucklandia lappa Decne is warm-natured, acrid flavour, hardship, nontoxic, returns spleen, stomach, large intestine, gallbladder channel, belongs to
Qi-regulating drug, be amusing for qi-regulating, reinforcing spleen to promote digestion, analgesic.
In the context of the present invention, term " dried orange peel " refers to Rutaceae evergreen dungarunga plant citrus (Citrus
Reticulata Blanco) and its belong to the ripe pericarps of various plants.Dried orange peel main product is in Guangdong, Fujian, Sichuan, Jiangsu, Zhejiang
The ground such as river.It collects when the fruit matures in the fall, it is dry.It is raw to use.Dried orange peel is warm-natured, acrid flavour, hardship, nontoxic, returns spleen, lung channel, belongs to qi-regulating drug,
For regulating qi-flowing for eliminating phlegm, invigorating the spleen to dry.
In the context of the present invention, term " Poria cocos " refers to On Polyporaceae Poria cocos (Poria cocos (Schw.)
Wolf sclerotium).Multiparasitization is on the tree roots such as pinaceae plant Japanese red pine or masson pine.Wild or cultivation, main product is in Yunnan, peace
The ground such as emblem, Hubei, Henan, Sichuan.7~September is excavated, and silt is removed, and after banking up " sweating ", spreads drying out to dry tack free, then
" sweating ", it is repeated multiple times, until wrinkle occurs, after internal moisture is mostly scattered and disappeared, dry in the shade；Or it by fresh Poria cocos cutting, dries in the shade.It is raw to use.
Poria cocos is mild-natured, sweet in flavor, light, nontoxic, the thoughts of returning home, spleen, kidney channel, belongs to damp-clearing drug, for clearing damp and promoting diuresis, spleen-benefiting mind-tranquilizing.
In the context of the present invention, term " rheum officinale " refers to polygonaceae herbaceos perennial sorrel (Rheum
Palmatum L.), Rheum tanguticum Maxim (Rheum tanguticum Maxim.ex Reg.) or Rheum officinale (Rheum
Officinale Baill.) root and rhizome.Sorrel and Rheum tanguticum Maxim medicinal material claim Beijing University yellow, and main product is in Qinghai, Gansu
Etc. ground.Rheum officinale medicinal material claims RADIX ET RHIZOMA RHEI OFFICILALIS, and main product is in Sichuan, Guizhou, Yunnan and other places.It is adopted before autumn end cauline leaf is withered or secondary spring is germinateed
It digs, removes fibrous root, scrape off crust, it is dry.It is raw to use, is parched with wine, frying charcoal or the ripe use of system.Rheum officinale is cold in nature, bitter, nontoxic, returns spleen, stomach,
Large intestine, the heart, Liver Channel belong to cathartic drug, for rushing down lower heat-clearing, purging intense heat defaecation, promoting blood circulation.
In the context of the present invention, term " profound Hu " refers to Papaveraceae herbaceos perennial corydalis tuber (Corydalis
Turtschaninovii Bess.f.yanhusuo Y.H.Chou et C.C.Hsu) stem tuber.It is wild or cultivation, main product in
Zhejiang.It is excavated after the Beginning of summer, removes seedling leaf and fibrous root, cleaned, entered boiling water and scald to boil, pull out, dry when seeing inside and outside turn yellow.Used time smashs to pieces
It is raw to use, or through vinegar system.Profound Hu Xingwen, acrid flavour, hardship are nontoxic, the thoughts of returning home, liver, the spleen channel, belong to blood circulation and stasis-eliminating medicine, for promoting the circulation of qi, promoting blood circulation,
Analgesic.
In the context of the present invention, term " Radix Polygalae " refers to Polygalaceae herbaceos perennial Radix Polygalae (Polygala
Tenuifolia Willd.) or wide leaf Radix Polygalae (Polygala sibirica L.) root.Radix Polygalae main product is in Shanxi, Shaanxi, Ji
The provinces such as woods, Henan.Spring and autumn can be excavated.Residual stem, fibrous root, soil are removed, cleans, dries.It is raw to use or process use.Radix Polygalae is micro-
Temperature, acrid flavour, hardship are nontoxic, return lung, the heart channel of Hang-Shaoyin, belong to sedative, have one's ideas straightened out for antitoxic heart-soothing and sedative, eliminating the phlegm, the carbuncle that disappears goes to swell.
In the context of the present invention, term " ginseng " refers to Araliaceae herbaceos perennial ginseng (Panax
Ginseng C.A.Mey.) root.Wild survivor is known as wild ginseng, and grower is known as garden ginsent.Ginseng main product in northeast each province, and with
Jilin Fusong County yield is maximum, best in quality.Ginseng slightly warm in nature, sweet in flavor, slight bitter is nontoxic, returns spleen, lung channel, belongs to Qi-tonifying drug, is used for
It reinforces vital energy, reinforce the spleen to benefit the lung, adjust flourish nourishing the stomach, promote the production of body fluid to quench thirst, calming the nerves increases intelligence.
In the context of the present invention, term " Radix Angelicae Sinensis " refers to Umbelliferae herbaceos perennial Radix Angelicae Sinensis (Angelica
Sinensis (Oliv.) Diels.) root.For Radix Angelicae Sinensis main product in the Minxian County (Qin Zhou) of Southeast Gansu Province, yield is more, high-quality；
Secondly, also there is cultivation on the ground such as Shaanxi, Sichuan, Yunnan.Autumn end excavates, and eliminates reed head, fibrous root.It is tied up after moisture slightly row evaporation,
With low baking temperature slowly smoke-dried beancurd.Slice is raw to be used, or is mixed through wine, use parched with wine.Radix Angelicae Sinensis is warm-natured, sweet in flavor, pungent, nontoxic, Return liver, the heart, the spleen channel, belongs to
Antianaemics, for enriching blood, invigorating blood circulation, relieve pain, ease constipation.
In an embodiment, the Chinese medicine composition for drug rehabilitation of the invention includes following group in parts by weight
Point：10~30 parts of airpotato yams, 5~15 parts of fruit of summer cypress, 5~15 portions of rhizoma alismatis, 10~20 parts of kuh-sengs, 20~50 parts of stir-baked SEMEN ZIZIPHI SPINOSAEs and 15~
40 parts of Cortex Eucommiaes preferably comprise 20 parts of airpotato yams, 10 parts of fruit of summer cypress, 9 portions of rhizoma alismatis, 12 parts of kuh-sengs, 30 parts of stir-baked SEMEN ZIZIPHI SPINOSAEs and 25 parts of Cortex Eucommiaes.
In a preferred embodiment, the Chinese medicine composition for drug rehabilitation of the invention also includes in parts by weight
Following component：10~30 parts of Fructus Forsythiaes, 10~20 portions of lilies, 5~20 parts of Rhizoma Gastrodiaes, 5~20 parts of seed of Oriental arborvitaes and 40~80 parts of Radix Astragalis, it is excellent
Choosing also includes 18 parts of Fructus Forsythiaes, 13 portions of lilies, 10 parts of Rhizoma Gastrodiaes, 10 parts of seed of Oriental arborvitaes and 60 parts of Radix Astragalis.
In a further preferred embodiment, the Chinese medicine composition for drug rehabilitation of the invention also includes in parts by weight
Following component：5~20 portions of honeysuckles, 5~20 portions of Schisandra chinensis, 5~15 parts of root of Aucklandia lappa Decne, 5~15 parts of dried orange peels, 5~15 parts of Poria cocos, 5
~15 parts of rheum officinales, 15~30 parts of profound Hus, 10~30 parts of Radix Polygalaes, 20~40 parts of ginsengs and 15~25 parts of Radix Angelicae Sinensis preferably also include 12
Part honeysuckle, 10 portions of Schisandra chinensis, 8 parts of root of Aucklandia lappa Decne, 8 parts of dried orange peels, 9 parts of Poria cocos, 8 parts of rheum officinales, 18 parts of profound Hus, 13 parts of Radix Polygalaes, 30 parts of people
Ginseng and 20 parts of Radix Angelicae Sinensis.
Be preferably used in the Chinese medicine composition of drug rehabilitation above-mentioned, airpotato yam, honeysuckle, Fructus Forsythiae, the fruit of summer cypress, Schisandra chinensis,
Medicinal material is aided with invigorating the spleen and is disappeared based on heat-clearing, toxin expelling, eliminating the phlegm, change gas simply for lily, root of Aucklandia lappa Decne, dried orange peel, Poria cocos, rheum officinale and rhizoma alismatis ten
Food, defaecation is drowned is generally corresponding to monarch drug in a prescription with toxin expelling for main symptom；Rhizoma Gastrodiae, profound Hu and three taste medicinal material of kuh-seng to relieve pain, it is antipruritic based on,
For accompanying symptoms, it is generally corresponding to ministerial drug；Radix Polygalae, the seed of Oriental arborvitae and three taste medicinal material of stir-baked SEMEN ZIZIPHI SPINOSAE with remove it is dry, calm the nerves, based on sleeping, assist monarch
Minister is generally corresponding to adjutant；Ginseng, Cortex Eucommiae, Radix Angelicae Sinensis and Radix Astragali four traditional Chinese medicine material with rich in nutrition, strengthen muscles and bones, based on reinvigoration,
Priming channel tropism, coordinating the drug actions of a prescription are generally corresponding to make medicine.
Secondly, the present invention provides the preparation methods of the Chinese medicine composition for drug rehabilitation of the present invention comprising by each taste
The step of medicinal material is weighed and is mixed.
In a preferred embodiment, preparation method of the invention further includes before weighing step by ingredients
The step pick, clean, dried.
Again, the present invention provides a kind of pharmaceutical preparations, during it includes the present invention of therapeutically effective amount for quitting drug abuse
Drug composition and one or more pharmaceutically acceptable carriers.
In the context of the present invention, it is following to refer to that biologically active substance can be realized for term " therapeutically effective amount "
Dosage when any one effect：(1) prevent or treat specified disease, illness or obstacle；(2) mitigate, improve or eliminate specific
One or more symptoms of disease, illness or obstacle；Or one kind or more of specified disease, illness or obstacle is prevented or delayed in (3)
The breaking-out of kind symptom.
In the context of the present invention, term " pharmaceutically acceptable carrier " refer to be suitable for it is thin with human body or animal body
Born of the same parents, tissue or organ are compatible, and will not induce the adjunct ingredient of the toxic side effects such as toxicity, irritation, allergy." pharmacy
Upper acceptable carrier " is known in the art, includes mainly solvent, solubilizer, cosolvent, emulsifier, corrigent, rectifys and smell
Agent, colorant, adhesive, disintegrant, filler, lubricant, wetting agent, osmotic pressure regulator, pH adjusting agent, stabilizer, table
Face activating agent, preservative etc..
In a preferred embodiment, pharmaceutical preparation of the invention is being used for for the present invention comprising therapeutically effective amount
The Chinese medicine composition of the drug rehabilitation and solid pharmaceutical preparation of one or more pharmaceutically acceptable carriers, semisolid preparation or liquid system
Agent, wherein：Applicable solid dosage form includes mainly tablet, capsule, granule, powder, sublimed preparation, pastille, pill etc.；It is suitable
Semisolid preparation form includes mainly gelling agent, suppository, paste, paste etc.；Applicable liquid forms include mainly
Decoction, mixture, suspension, solution etc..
Finally, the present invention provides a kind of methods for drug rehabilitation comprising the sheet of therapeutically effective amount is applied for drug addict
The step of Chinese medicine composition for drug rehabilitation of invention.Using when, made with one month as a treatment course；First 7 days, 4 times a day, often
6 hours primary, 5~10 grams every time；After 7 days, 3 times a day, for every eight hours once, 3~8 grams every time.
Carry out the technical solution during the present invention is further explained below with reference to specific embodiment.Under it should be understood that
Row embodiment is only used for the explanation and illustration present invention, and the protection domain being not intended to restrict the invention.Unless otherwise indicated, under
Instrument, material and reagent for being used in row embodiment etc. can be obtained by routine business means.
1~embodiment of embodiment 6：The preparation of the Chinese medicine composition for drug rehabilitation of the present invention.
The ingredients for being used to prepare Chinese medicine composition is picked and (removes soil, foreign matter etc.), cleaning is (using originally
Water cleans) and it is dry (dry in the shade or dry), and weighed according to the actual amount of ingredients in table 1, it will be each after weighing
After the mixing of taste medicinal material to obtain the final product.
The recipe list of 1. Chinese medicinal drug withdrawal composition of table
Embodiment 7：The zoopery of the Chinese medicine composition for drug rehabilitation of the present invention.
(1) model foundation：
Under aseptic processing environment, 80 adult SD rats (half male and half female, 300~350g of weight) are placed in cage, and
And every rat individually houses.Morphine is dissolved in sterile physiological water, 5d or more is incrementally administered.1~4d, per 1h gavage morphines
1.5mg/kg, 16 times a day.5d, per 4h gavage morphines 15mg/kg.After 6d, per 6h gavage morphine 15mg/kg, as
Maintenance dose.Between each gavage in the phase, rat, which will appear, significantly shakes precursor reactant, can be eliminated after gavage morphine 15mg/kg
Above-mentioned reaction.This precursor reactant that shakes can be repeatedly observed in all rats, as withrawal symptom.In addition, according to same
Method, dosage and the frequency are that 10 adult SD rats (half male and half female, 300~350g of weight) gavages apply physiological saline, equal nothing
Shake precursor reactant appearance.
(2) prepared by drug：
It is prepared by liquid：Chinese medicine composition in Examples 1 to 6 is added separately in the pure water of 10 times of weight, intense fire
It decocts and turns slow boiling to after boiling, until stopping heating when decocting liquid weight is 3 times of medicinal material dry weight, dry in the air to room after filtering out the dregs of a decoction
Temperature is to get the corresponding Traditional Chinese medicine composition liquid medicine of Examples 1 to 6.
The preparation of positive control liquid：Buprenorphin hydrochloride is dissolved in physiological saline to get positive control liquid.
(3) animal packet and treatment：
The rat model that 80 are addicted to drug is divided into 8 groups (every group 10), is denoted as 1 group of embodiment, embodiment 2 respectively
Group, 3 groups of embodiment, 4 groups of embodiment, 5 groups of embodiment, 6 groups of embodiment, positive controls and dopy model group.Body is shaken to count
6h starts after morphine gavage, observing time 30min, wherein for 1 group~embodiment of embodiment, 6 groups of rat oral gavage Examples 1 to 6
Corresponding Traditional Chinese medicine composition liquid medicine, dosage are about 50mg (in terms of medicinal material dry weight)/kg/；It is filled for positive controls rat
Stomach positive control liquid, dosage are about 25mg (in terms of buprenorphine)/kg/；For dopy model group rats gavage and sun
Property the identical physiological saline of control medicine liquid volume.In addition, for 10 blank group (processing of physiological saline gavage) rat oral gavages and sun
Property the identical physiological saline of control medicine liquid volume.Occur shaking the rat quantity of precursor reactant according to same method observation.
(4) experimental result：
By the result in table 2 it is found that the corresponding Traditional Chinese medicine composition liquid medicine of Examples 1 to 6 can significantly reduce morphine addiction
Rat shakes body number, and the test result of embodiment 5 and 6 corresponding Traditional Chinese medicine composition liquid medicines is significantly better than positive control drug,
Show that the Chinese medicine composition for drug rehabilitation of the present invention can play drug rehabilitation effect, withrawal symptom is effectively relieved.
2. Chinese medicinal drug withdrawal composition of table shakes rat in 30 minutes the influence result that body counts (x ± s)
| Group | It shakes body and counts (secondary) | Group | It shakes body and counts (secondary) |
| 1 group of embodiment | 40±0.3 | 6 groups of embodiment | 5.0±0.7* |
| 2 groups of embodiment | 32±0.7 | Positive controls | 31.0±0.8 |
| 3 groups of embodiment | 33±0.4 | Dopy model group | 52.0±0.5* |
| 4 groups of embodiment | 25±0.5 | Blank group | 0.0±0.0* |
| 5 groups of embodiment | 12±0.9* |
Embodiment 8：Include preparation and the usage of the pharmaceutical preparation of Chinese medicine composition for drug rehabilitation.
The preparation method of pill：By taking embodiment 6 as an example, ingredients is picked, clear water is cleaned, and first impregnates 2h, then decoct
1h adds clear water to decoct second, the medicine soup decocted twice is merged, then paste is boiled into small fire, adds edible shallow lake again after filtering
Pill is made using pellet processing machine in powder and preservative, and disinfection is packed to obtain the final product.
The preparation method of capsule：Above-mentioned ointment is dried, powder is beaten, is sieved with 100 mesh sieve, is fitted into after infrared sterilization in capsule shells i.e.
.
Instructions of taking：Made with one month as a treatment course；It first 7 days, 4 times a day, is taken once per 6h, each 6g；7 days
Afterwards, 3 times a day, it is taken once per 8h, each 5g.
Embodiment 9：The clinical case of the Chinese medicine composition for drug rehabilitation of the present invention.
The clinical case result of Chinese medicinal drug withdrawal composition in 3. embodiment 6 of table
By the result in table 3 it is found that the Chinese medicine composition for drug rehabilitation of the present invention can be directed to a variety of common drugs hairs
Drug abstinence is waved, the length for time of no matter taking drugs, cure rate is all up to 83.3%~100.0%.Also, in addition to heroin with
Outside, the relapse rate of other drugs is also effectively controlled.
The concrete condition of partial clinical case is set forth below：
Liu Mr. and Mrs, people from Yingshan Mountains, two people are guarded against by force and are gone certainly totally 11 person-times of Wuhan drug rehabilitation, not successfully.Liu husband
Certain, 32 years old, sucks heroin 8 years, and with AIDS, when drug rehabilitation takes anti-AIDS drug to control the state of an illness；Wife it is deep so-and-so,
31 years old, receive the treatment of Chinese medicinal drug withdrawal composition, 14 points of medications on June 8th, 2014, that night has detoxification reflection, husband Liu
Late 2 hours have reflection, every 4 hours to take medicine 1 time, actively cooperation medication.Caligation in initial two days, speaks indiscreetly words, does not feed,
It stays up, urine is more, constipation, and be occasionally addicted to drugs breaking-out symptom, but once medication, symptom totally disappeared.At the 13rd day, Liu
Mr. and Mrs reflect body recovery from illness, are strongly required to go home, and continue medication 20 days after going home.When return visit, husband and wife is in vigorous health strong, essence
Refreshing state is full.
Europe so-and-so, man, 23 years old, people from Liuzhou sucked Ketamine 6 years, receive on May 11st, 2015 Chinese medicinal drug withdrawal composition treatment,
200 jin of weight before treatment, arteries and veins is thin, and it is black dull that face is unglazed, red tongue body, and whens same day 6 takes medicine, and 4 times a day, and takes spirulina, one day 2
It is secondary, one time 10.To 17 days, for tripe swollen without stool, urine was normal, take aplotaxis carminative pill 1 packet, defaecation spirit 5,4 hours after gas
The stool that disappears comes.Since urine test result on the 16th shows substantially nontoxic, requirement on the 18th is gone home, and continues medication 4 days after going home.It returns
When visit, so-and-so face of Europe give up substantially by gain color, drug addiction.
Qiu so-and-so, man, 20 years old, Yongan village people sucked heroin 6 years, injected 3 years, strong to guard against and failed from guarding against repeatedly,
Receive the treatment of Chinese medicinal drug withdrawal composition on June 9th, 2014, actively cooperation medication, but midway once goes home to inhale steathily three times, every time privately
It feels again and returns and continue to receive treatment, go home after two weeks of persistently quitting drug abuse, continue medication 40 days after going home.When return visit, Qiu
The weight of certain increases to 150 jin from 90 jin before drug rehabilitation, and face improves entirely, calls oneself drug addiction and totally disappeared.
Dong, man, 34 years old, people from Zhejiang sucked methamphetamine 2 years, not yet generates serious illusion, receives Chinese medicinal drug withdrawal composition and controls
After treatment, medication 6 times daily just have detoxification reflection after half a day, the 5th day conscious physical condition is recovered normal, and appetite increases,
Result is negative when the 12nd day urine test, continues to take medicine after going home.When return visit, drug addiction has disappeared, and the state of mind is good.
Thank so-and-so Mr. and Mrs, people from the villages La Ta.Husband thanks so-and-so, 35 years old, take drugs 4 years, wife's Wei so-and-so, 32 years old, take drugs 2 years,
It not yet injects, failed from guarding against repeatedly, September in 2014 receives the treatment of Chinese medicinal drug withdrawal composition on the 15th, and two human connections are counted accurately, tongue nature
It is red, and have indentation, 3 points of medications of the same day, next day just has detoxification reflection, husband's productive cough not to go out, speaks indiscreetly words, rarely has feed, cruel thermophilic smoking.
It is entirely good to call oneself to fortnight, it is desirable that continues to take medicine after going home.When return visit, husband and wife claim drug addiction to substantially eliminate, body shape
State has taken a favorable turn, and the custom for having a liking for smoking has made moderate progress.
Mr. Li, male, 40 years old, Lingui County five led to people, injected heroin, sucks methamphetamine, numb stone, connects on November 17th, 2014
It is treated by Chinese medicinal drug withdrawal composition, success detoxification on December 12nd, 2014, and has restored good body.
Mr. Li, male, 42 years old, Lingui County five led to people, injected heroin, sucked methamphetamine, took drugs 23 years, guarded against tens of times certainly
Not successfully, receive the treatment of Chinese medicinal drug withdrawal composition on November 4th, 2014, detoxification, and fast quick-recovery were controlled successfully by 43 days rings
Body.
The Qin so-and-so, female, 37 years old, Lingchuan County Longkou people from village sucked methamphetamine 3 years, and on November 13rd, 2014 receives Chinese medicinal drug withdrawal
Composition is treated, success detoxification on November 24th, 2014, body of resting of voluntarily going home after detoxification.
It is deep so-and-so, man, 41 years old, people from Liujiang County sucked injection 12 years, and whole body is nowhere had an injection, and Chinese medicinal drug withdrawal composition is received
Treatment is given up after 12 days.
It is deep so-and-so, man, 35 years old, in cross dotey people from pool, suck injection heroin 12 years, receive the treatment of Chinese medicinal drug withdrawal composition
It is given up after 18 days.
Deng, man, 25 years old, Luzhai stockaded village sand people sucked heroin 6 years, no father, and mother is chairman of the village committee, and son is sent to connect
When being treated by Chinese medicinal drug withdrawal composition, complains tearfully and be ashamed of seeing people because of its sub- drug abuse.After continuous treatment ten days, calls oneself drug addiction and guarded against
Fall.When return visit, hundreds of mu of tree of cutting into a mountain kind of being in has girlfriend, prepares to get married, and the whole family thanks endless without unhappy.
Dragon so-and-so, man, 42 years old, Guilin people from Lingchuan claimed that various drugs have contamination, the ground such as Changsha, Zhuhai is gone to guard against by force certainly
Failed, August in 2015 receives the treatment of Chinese medicinal drug withdrawal composition on the 13rd, and only medication has i.e. more prepared learning Chinese medicine in 8 days
Medicine resolves to cure the sickness to save the patient.
Claims (14)
1. a kind of Chinese medicine composition for drug rehabilitation, it includes airpotato yam, the fruit of summer cypress, rhizoma alismatis, kuh-seng, stir-baked SEMEN ZIZIPHI SPINOSAE and Cortex Eucommiaes.
2. the Chinese medicine composition according to claim 1 for drug rehabilitation, it is characterised in that：It also includes Fructus Forsythiae, lily, day
Fiber crops, the seed of Oriental arborvitae and Radix Astragali.
3. the Chinese medicine composition according to claim 2 for drug rehabilitation, it is characterised in that：It also includes honeysuckle, the five tastes
Son, root of Aucklandia lappa Decne, dried orange peel, Poria cocos, rheum officinale, profound Hu, Radix Polygalae, ginseng and Radix Angelicae Sinensis.
4. the Chinese medicine composition according to any one of claim 1 to 3 for drug rehabilitation, it is characterised in that：With parts by weight
Meter, it includes 10~30 parts of airpotato yams, 5~15 parts of fruit of summer cypress, 5~15 portions of rhizoma alismatis, 10~20 parts of kuh-sengs, 20~50 parts of stir-baked SEMEN ZIZIPHI SPINOSAEs
With 15~40 parts of Cortex Eucommiaes.
5. the Chinese medicine composition according to claim 4 for drug rehabilitation, it is characterised in that：In parts by weight, it includes 20
Part airpotato yam, 10 parts of fruit of summer cypress, 9 portions of rhizoma alismatis, 12 parts of kuh-sengs, 30 parts of stir-baked SEMEN ZIZIPHI SPINOSAEs and 25 parts of Cortex Eucommiaes.
6. the Chinese medicine composition according to claim 2 or 3 for drug rehabilitation, it is characterised in that：In parts by weight, it includes
10~30 parts of Fructus Forsythiaes, 10~20 portions of lilies, 5~20 parts of Rhizoma Gastrodiaes, 5~20 parts of seed of Oriental arborvitaes and 40~80 parts of Radix Astragalis.
7. the Chinese medicine composition according to claim 6 for drug rehabilitation, it is characterised in that：In parts by weight, it includes 18
Part Fructus Forsythiae, 13 portions of lilies, 10 parts of Rhizoma Gastrodiaes, 10 parts of seed of Oriental arborvitaes and 60 parts of Radix Astragalis.
8. the Chinese medicine composition according to claim 3 for drug rehabilitation, it is characterised in that：In parts by weight, it includes 5~
20 portions of honeysuckles, 5~20 portions of Schisandra chinensis, 5~15 parts of root of Aucklandia lappa Decne, 5~15 parts of dried orange peels, 5~15 parts of Poria cocos, 5~15 parts of rheum officinales, 15~
30 parts of profound Hus, 10~30 parts of Radix Polygalaes, 20~40 parts of ginsengs and 15~25 parts of Radix Angelicae Sinensis.
9. the Chinese medicine composition according to claim 8 for drug rehabilitation, it is characterised in that：In parts by weight, it includes 12
Part honeysuckle, 10 portions of Schisandra chinensis, 8 parts of root of Aucklandia lappa Decne, 8 parts of dried orange peels, 9 parts of Poria cocos, 8 parts of rheum officinales, 18 parts of profound Hus, 13 parts of Radix Polygalaes, 30 parts of people
Ginseng and 20 parts of Radix Angelicae Sinensis.
10. the preparation method of the Chinese medicine composition according to any one of claim 1 to 9 for drug rehabilitation comprising will
The step of ingredients is weighed and is mixed.
11. a kind of pharmaceutical preparation, it includes the according to any one of claim 1 to 9 for quitting drug abuse of therapeutically effective amount
Chinese medicine composition and one or more pharmaceutically acceptable carriers.
12. pharmaceutical preparation according to claim 11, it is characterised in that：The pharmaceutical preparation is solid pharmaceutical preparation, semisolid
Preparation or liquid preparation.
13. pharmaceutical preparation according to claim 12, it is characterised in that：The solid pharmaceutical preparation include tablet, capsule,
Granula, powder, sublimed preparation, pastille and/or pill；The semisolid preparation includes gelling agent, suppository, paste and/or paste；It is described
Liquid preparation includes decoction, mixture, suspension and/or solution.
14. the use according to any one of claim 1 to 9 for the Chinese medicine composition of drug rehabilitation in preparing anti-additive medicament
On the way.
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