CN108261343A - Foaming dentifrice composition based on protein - Google Patents
Foaming dentifrice composition based on protein Download PDFInfo
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- CN108261343A CN108261343A CN201611270979.XA CN201611270979A CN108261343A CN 108261343 A CN108261343 A CN 108261343A CN 201611270979 A CN201611270979 A CN 201611270979A CN 108261343 A CN108261343 A CN 108261343A
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- CN
- China
- Prior art keywords
- dentifrice composition
- toothpaste
- protein
- calcium caseinate
- surfactant
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The present invention relates to a kind of dentifrice compositions, and it includes the total weight based on the dentifrice composition, 0.05 5.5% calcium caseinates, wherein substantially free of oil components in the dentifrice composition.
Description
Technical field
The present invention relates to a kind of dentifrice compositions, and it includes the total weight 0.05-5.5%'s based on the dentifrice composition
Calcium caseinate is as surfactant, wherein substantially free of oil components in the dentifrice composition.
Background technology
Toothpaste is the various daily neces saries of people.As the product daily with oral cavity close contact, the safety of toothpaste and its
Influence to health of people has become focus of concern.
Surfactant is required component in tooth paste product.US4,058,595 discloses common surface in toothpaste and lives
Property agent, such as the higher fatty acid amides of alkylaryl sulfonates, higher alkyl sulfoacetates, taurine, sorbitol anhydride list
Stearate etc..But there may be irritation, the mistakes of skin to mucous membrane for the surfactant and its decomposition product of these synthesis
Quick property, toxicity and carcinogenicity so that the safety of toothpaste by consumer extensive concern.
Additionally it has been disclosed that protein ingredient is used in toothpaste.Such as US2006/0222602 A1 disclose cleaning tooth
Dentifrice composition includes nano particle and protein component such as soybean protein, junket egg in the calcium salt ingredient that the dentifrice composition includes
It is white etc..The dentifrice composition is also lived comprising anion surfactant, amphoteric ion and amphoteric surfactant, non-ionic surface
The mixture of property agent, cationic surfactant or these compounds.The dentifrice composition has both soft processing and clean work(
Effect.
103211716 B of CN are disclosed to be made using with some surface active property protein or protein-based surfactant
The method for manufacturing toothpaste uniquely to clean cleaning ingredients, wherein described have some surface active property protein or protein-based surface
Activating agent be soybean protein acid sodium, silk protein acid calcium, native silk protein emulsifier or one kind in casein sodium, two kinds,
Three kinds or four kinds.
Therefore, it is desirable to the use of synthetic surfactant is reduced as far as possible but still includes spatter property, foaming with excellent
The tooth paste product of physical property and good security including property.
Invention content
On the one hand, the present invention relates to a kind of dentifrice compositions, and it includes the pacts based on the dentifrice composition total weight
The calcium caseinate of 0.05-5.5%, wherein substantially free of oil components in the dentifrice composition.
In one embodiment, dentifrice composition is also comprising at least one edible albumen.Edible albumen may be selected from greatly
Legumin, lactalbumin and albumen.In preferred embodiments, the total amount of calcium caseinate and edible albumen is tooth
The about 0.05-20% of composite cream.
On the other hand, the invention further relates to a kind of methods for preparing dentifrice composition, are included in dentifrice composition and mix
Close calcium caseinate or its mixture with edible albumen.
Description of the drawings
Fig. 1：The dentifrice composition of the present invention and the form of commercially available dentifrice composition compare.
Fig. 2：The dentifrice composition of the present invention is compared with the foam performance of commercially available dentifrice composition.
Fig. 3：The dentifrice composition of the present invention is compared with the clean-up performance of commercially available dentifrice composition.
Specific embodiment
General definition and term
If do not otherwise indicated, all publications mentioned herein, patent application, patent and other bibliography lead to
It crosses to quote and be herein incorporated by reference in its entirety.
Unless otherwise defined, there are all technical and scientific terms used herein those skilled in the art usually to manage
The identical meanings of solution.In the case of a conflict, according to the definition in this specification.
Except indirect explanation, trade mark is represented in the form of subscript.
Unless otherwise indicated, all percentage, number, ratio etc. are by weight.
When providing quantity, concentration or other values or parameter as range, preferred scope or preferred upper limit value and lower limiting value
When, it is to be understood as specifically disclosed from arbitrary upper range or preferred value and arbitrary lower range or preferred value into logarithm
All ranges that value is formed, regardless of whether range is individually disclosed.Unless otherwise indicated, when herein cited numberical range
When, the range refer to include its endpoint and it is all should in the range of integer and score.The scope of the present invention is not intended to limit
Cited special value when the range of definition.
When term " about " is used to describe numerical value or range endpoints, it should be understood that disclosure of that includes cited specific
Value or end value.
As used herein, the packet for being intended that nonexcludability of term " comprising ", "comprising", " having " or other modifications
Hold.Composition, process, method, object or the device of e.g., including a series of components are not necessarily limited to only these components,
It may also include the component do not listed directly or the composition, process, method, object or the intrinsic component of device.
In addition, not indicating number before the component or component of the present invention, represent that the appearance for component or component (or is deposited
) number be there is no limit.Therefore, it should be read as including one or at least one, and component or the singular morphology of component
Formula also includes plural number, unless the numerical value clearly indicates that odd number.
Term as used herein " optional " " optionally " refers to the event then described or situation may occur or can
It can not occur, which includes the event or situation occurs and the event or situation does not occur.For example, in dentifrice composition
Optionally comprising flavoring agent, represent there can be flavoring agent in dentifrice composition, can also there is no flavoring agent.
Term as used herein substantially free represents, the total weight based on dentifrice composition, in dentifrice composition
The content of tie element is about 1% hereinafter, preferably from about 0.5% hereinafter, more preferably from about 0.05% hereinafter, most preferably 0%.
Term as used herein " surfactant " is also known as interfacial agent, this is that a kind of energy changes and (usually reduce) liquid
The substance of body surface tension or two interphase interface tension.Surfactant have it is amphipathic, contain hydrophilic radical and lipophilic group.
The example of hydrophilic radical includes but not limited to amino, carboxyl, sulfonic group, hydroxyl etc., and the example of hydrophobic grouping includes but not limited to
C8And its above aliphatic alkane, alkene, alkynes and aromatic hydrocarbon etc..The example of common surfactant includes but not limited to
Natural surfactant or derivatives thereof and the surfactant of synthesis.The example of natural surfactant or derivatives thereof has
Surfactant based on protein.The example of the surfactant of synthesis has neopelex, Hamposyl L
Sodium, Cocoamidopropyl betaine, sorbitan fatty acid ester, methyl glycol fatty acid ester etc..In preferred embodiments,
Surfactant of the dentifrice composition substantially free of synthesis of the present invention.
Term as used herein " calcium caseinate " be usually from casein, such as by acidification and/or basification,
And the product for reacting and preparing with soluble calcium salt or alkaline calcium, wherein calcium exist in the form of ion, can in casein
Serine phosphate moiety stable bond.Calcium caseinate is purchased from such as DMV companies of Holland.
Term as used herein " oil components " refers to the oil-based solvent being generally comprised in dentifrice composition or oleophylic object
Matter, such as can be by being introduced in flavoring agent, that is, flavoring in remaining oiliness extractant in fragrant ingredient or flavoring.
The example of oil components includes but not limited to natural oil, Synthetic Oil, vegetable fat, margarine or animal fat, such as
Dimethyl silicone polymer, dimethicone, foeniculum piperitum Coutibo oil, peppermint oil, triacetyl glycerine etc..
Dentifrice composition
Calcium caseinate or its mixture with edible albumen are used as surface-active in the dentifrice composition of the present invention
Agent exists.Total weight based on dentifrice composition, the content of calcium caseinate can be about 0.05-5.5%, about 1.5-4.5%,
About 1-4% or about 2-4%, for example, about 0.1%, about 0.5%, about 1%, about 2%, about 3%, about 4%, about 5% etc..
The edible albumen being used in combination with calcium caseinate can be the mixing of animal protein, vegetable protein or the two
Object.The example of animal protein includes but not limited to lactalbumin, collagen, fibrin, elastin laminin, keratin, egg white
Albumen, placental protein, casein etc..The example of vegetable protein includes but not limited to wheat gluten, soybean protein, rice gluten, pea
Legumin, almond protein, peanut protein, potato protein, avenin etc..In preferred embodiments, edible albumen
Following edible albumen is selected from comprising at least one：Soybean protein, lactalbumin and albumen.Soybean protein for example can be with
Use the product I SP-672 or ISP-760C of Danisco A/S BJ Rep Office of Du Pont.Lactalbumin can for example use U.S. Himlar public
The product WPC 80 of department.Albumen can for example use the product PL 25053 of Danisco A/S BJ Rep Office of Du Pont.
In the dentifrice composition of the present invention, the ratio of calcium caseinate and edible albumen is not particularly limited, such as
It can be about 1: 99-99: 1, be such as about 1: 1.But the total weight based on dentifrice composition, calcium caseinate and edible eggs
White total amount is about 0.05-20%, preferably from about 2-10%, more preferably from about 2-5%.
Based on calcium caseinate or its use with edible protein combination, dentifrice composition of the invention substantially free of
Oil components mentioned above, such as natural oil, Synthetic Oil, vegetable fat, margarine or animal fat, three acetic acid are sweet
Grease etc..
Thickener would generally be included in the dentifrice composition of the present invention.Using for thickener can cause toothpaste to have suitably
Viscosity and consistency keep good mobility, have good stability；Also toothpaste can be caused to have good thixotropy simultaneously
With it is water-soluble, easily dispersion does not lump, does not influence the color and luster of toothpaste.Thickener in the toothpaste of the present invention can include carboxymethyl
Sodium cellulosate, hydroxyethyl cellulose, xanthans, carragheen or its mixture, preferably carboxymethyl cellulose sodium, xanthans or it is mixed
Close object.
The dentifrice composition of the present invention can also optionally include flavoring agent.Flavoring agent is the substance for improving toothpaste mouthfeel.
The flavoring agent used in toothpaste is mainly various essence.Toothpaste essence can enhance the comfortable taste brushed teeth.According to dissolved into
Point, essence includes oil soluble perfume and soluble perfume.Preferably, do not include any oil components in essence substantially, such as
Those already mentioned above oil components, such as triacetyl glycerine, vegetable fat, margarine or animal fat.If it uses
Essence, then it is preferable to use water-soluble essence, to avoid the introducing of oil components.The example of soluble perfume includes but not limited to grass
Certain kind of berries essence, citrus flavor, flavoring banana essence etc., more preferably strawberry essence.
The dentifrice composition of the present invention can also optionally include sweetener.Sweetener be there is sweet tea sense cover other
The unhappy substance felt that ingredient is brought.Sweetener includes natural sweetener and artificial synthesis edulcorant.Natural sweetener
Example includes but not limited to stevioside, disodium glycyrrhizinate, xylitol, antierythrite, maltose, sucrose, tripotassium glycyrrhetate, Radix Glycyrrhizae
Sour trisodium etc..The example of artificial synthesis edulcorant includes but not limited to saccharin sodium, acesulfame potassium, honey element, Aspartame, trichlorine sugarcane
Sugar, neotame etc..Present invention preferably uses the mixtures of natural sweetener, preferably stevioside, maltose or the two.
The dentifrice composition of the present invention can also optionally include abrasive material.Abrasive material be it is a kind of by the way of friction by tooth
The tartar and odontolith on surface remove, disperses component to clean tooth.The example of abrasive material includes but not limited to calcium carbonate, dioxy
SiClx, hydroxyapatite, Dicalcium Phosphate and its mixture, preferably silica.
The dentifrice composition of the present invention can also optionally include preservative.Preferably, preservative has to be edible
The preservative of excellent biodegradability has excellent fungistatic effect in the range of more wide in range pH.The example of preservative
Including but not limited to arbitrary two or three of mixture of sorbic acid, sodium benzoate, paraben esters or foregoing preservatives, preferably
Paraben esters.
The dentifrice composition of the present invention can also optionally include antioxidant.Antioxidant can avoid or delay toothpaste group
The oxidation of object is closed, the stability of toothpaste is improved and helps to extend shelf life.The example of antioxidant includes but not limited to 2,6-
Di-tert-butyl-4-methy phenol, tocopherol, vitamin C, tea polyphenols or its mixture, preferably tea polyphenols.
The dentifrice composition of the present invention can also optionally include buffer.The example of buffer includes but not limited to lemon
Acid/citrate, NaHCO3Deng.
In order to adapt to the environment in oral cavity, the pH of composition of the invention is about 5-11, preferably from about 5.5-10.0.
The dentifrice composition of the present invention can also optionally include NaCl.NaCl can be used for improving foam stability, reduce
Surface tension, while also there is the effect of sterilization, moisturizing.
If desired, dentifrice composition of the invention can also include and prepare common other compositions or addition in tooth paste product
Agent, such as colorant, desensitizer, antilithic etc..
The physicochemical property of dentifrice composition can pass through consistency, viscosity, adhesiveness, foaminess and toothpaste form after extrusion
It keeps evaluating.
The assay method of toothpaste consistency can test the consistometric value of toothpaste for example, by using consistency frame method.Specifically, by toothpaste
Shell is screwed on measuring head and (ensures that toothpaste is in the strip of 2mm or so diameter after squeezing out), at the uniform velocity and is equably extruded on testing jig,
Squeeze 3.Timing 1min, reading.In 3 toothpaste 2 constantly when position reading be exactly the toothpaste consistometric value.Suitable is thick
Degree is preferably 6-36mm.The viscosity of toothpaste can be measured for example, by using Brookfield viscosimeters, suitable viscosity is preferably 100-
400cp.When viscosity is more than 999cp, it is not suitable as toothpaste use.
Tooth paste product usually requires that relatively low adhesiveness.Adhesiveness refers to similar to the characteristic of glue or adhesive i.e. so that not
The property of the two kinds of binding substances that can be bonded together.It is evaluated herein by the mode that simulation is brushed teeth：By 1 gram of toothpaste
It is extruded into a 5 × 5cm2Two printing papers among, smear uniform, be stored at room temperature 5min, then open two pieces of paper, evaluate it
The degree being bonded together.If toothpaste is not sticked on another a piece of paper, represented with " 0 "；If there is 1/3 opposite side for sticking at paper,
It is represented with " 1 "；If there is the opposite side that 1/3-2/3 sticks at paper, represented with " 2 "；If the opposite side for having ＞ 2/3 to stick at paper, is used
" 3 " represent.Only the adhesive composition for " 0 " could be used as toothpaste.
Herein, the foaminess of toothpaste measures in the following way：A 4cm long toothpaste is squeezed out in plastic mesh container
The back side takes the true frequency of brushing teeth of toothbrush simulation, brushes 1min repeatedly, and the foaming characteristic on observation toothpaste surface is commented with the number of 1-10
Valency.It is used as toothpaste, foaminess is preferably 7-10.Foaminess represents to foam for 0.
Toothpaste needs that original form is kept not cave in substantially after the extrusion, and height will not reduce rapidly.In this hair
It in bright, is evaluated using the number of 1-3, wherein 3 is optimal for form.
Preparation method
The invention further relates to a kind of methods for preparing dentifrice composition, are included in dentifrice composition and mix calcium caseinate
Or its mixture with edible albumen.
Herein, adding calcium caseinate or the sequence of its mixture with edible albumen does not have particular/special requirement.Example
Such as, it can be added in the mixing periods of each ingredient of dentifrice composition, as long as can uniformly be mixed in it in dentifrice composition.
In one embodiment, preparation method includes：
(1) flavoring agent, sweetener, buffer, preservative, NaCl are dispersed in water；
(2) antioxidant is dispersed in the solution of step (1) acquisition；
(3) calcium caseinate or its mixture with edible albumen are dispersed in the solution of step (2) acquisition；
(4) thickener of mixing and abrasive material are dispersed in the solution of step (3) acquisition；
(5) product for obtaining (4) deaerates to obtain dentifrice composition.
The dentifrice composition of the present invention can be suitble to different preparation methods or/device, as long as by each of dentifrice composition
Component sufficiently uniformly mixes.
Mixing can be used stirring and realize.The temperature of stirring does not require particularly, as long as each ingredient is kept at such a temperature
Stable state will not volatilize, degrade, being denaturalized, aging etc..It will be appreciated by those skilled in the art that for different
Ingredient, stir speed (S.S.) will be different, and can correspondingly adjust.For water-soluble micromolecular compound such as sweetener,
Flavoring agent, buffer, tension regulator, preservative, antioxidant etc. preferably are gently mixed to reach mixed effect.
Calcium caseinate or its mixture with edible albumen can be during preparation any step add in.For example,
In the method for above-mentioned example, the adding procedure of step (3) can optionally become after step (1) or in step (4)
It carries out later, as long as it uniformly can be mixed and be disperseed with the other compositions in dentifrice composition.
Calcium caseinate or its mixture with edible albumen can also be added portionwise during preparation.For example, upper
State in exemplary method, can optionally be added portionwise after step (1), step (2) or the step (4) calcium caseinate or its
With the mixture of edible albumen.
The addition of the macromolecular substances such as calcium caseinate or its mixture with edible albumen is needed with faster rate
Stir the regular hour.For example, it can be stirred under the rate of about 1000-3000rpm, preferably from about under the rate of 1500-2500rpm
Stirring.Mixing time can be about 2-10min, preferably stir about 3-6min.
The addition of thickener and abrasive material is uniformly mixed sometimes for higher mixing speed and longer mixing time with reaching
The effect of conjunction.For example, can be stirred under the rate of about 3000-5000rpm, preferably from about stirred under the rate of 3500-4500rpm.
Mixing time can be about 5-20min, preferably stir about 8-15min.Those skilled in the art can be conventional according to actual needs
Ground is selected.
Advantageous effect
The dentifrice composition of the present invention uses edible albumen to have good cleaning, foaminess as surfactant
Can, the use of the surfactant of synthesis has been decreased or even eliminated, has reduced that there may be the irritation to mucous membrane, the mistakes of skin
The worry of safety problem that quick property, toxicity and carcinogenicity and consumer are related to dentifrice composition, especially there is more high safety
The specific crowd of demand such as children, pregnant woman, women breast-feeding their children and the crowd for pursuing healthy Lifestyle.
The preparation method of the present invention is very simple, quick, formulation cost is low, before having a vast market potentiality and application
Scape.
Embodiment
In the examples below, ingredient used is commercial product.Wherein, calcium caseinate is purchased from DMV companies of Holland；
Casein (PL43117), casein sodium (702396), xanthans (DAI-SH), sodium carboxymethylcellulose (IH9
9H1000), albumen (PL25053), maltose are purchased from Danisco A/S BJ Rep Office of Du Pont.
Embodiment 1-4
Preparation method
It is prepared as follows dentifrice composition.
(1) maltose, citric acid, stevioside, paraben esters, Mint Essence and NaCl are mixed and dispersed in water；
(2) tea polyphenols are dispersed in the solution of step (1) acquisition；
(3) calcium caseinate, casein sodium or casein is added in the solution obtained to step (2), in 2000rpm
It is lower to stir 5min to be uniformly dispersed；
(4) well-mixed xanthans, sodium carboxymethylcellulose, silica are added in the solution obtained to step (3)
In, and 10min is stirred with fully dispersed under 4000rpm；
(5) by the product degassing of above-mentioned steps (4).
The component content and performance parameter of product are as shown in table 1, wherein other than ingredient listed in table, each production
Product include following component (weight %)：
Xanthans：0.5, sodium carboxymethylcellulose：0.5, SiO2-MII：18, the maltose of 80% concentration (w/w)
Solution：35, stevioside RA97：0.4, tea polyphenols：0.8, Citric Acid Mono：0.2, NaCl：0.8, paraben esters：0.2；And with steam
Distilled water polishing is to 100.
As a result：
As shown in table 1, when using calcium caseinate as surfactant, product has excellent form and excellent
Foam performance.When using casein sodium as surfactant (comparative example 1-4), adhesiveness is not 0, is not suitable as
Toothpaste uses.When similarly, using only casein as surfactant (comparative example 5-8), adhesiveness is not 0, also uncomfortable
Cooperate to use for toothpaste.
In addition, when adding Mint Essence (being oil soluble perfume purchased from Guangzhou Man Ting fragrant materials Co., Ltd) in product
When (comparative example 9-20), can not foam, be not suitable as toothpaste use.
Fig. 1 is the picture for the form for evaluating embodiment 3 and 4 and commercial toothpastes, it is observed that the product of embodiment 3 and 4
There is good form to keep.
Embodiment 5-7
Dentifrice composition, the component content (weight %) and property of each product are similarly prepared according to the method for embodiment 1-4
Energy parameter is as shown in table 2.
Table 2
Note："/" represents that viscosity can not detect greatly very much
As a result：
As shown in table 2, when the content of calcium caseinate is less than 6% (such as 0.1%, 1% and 5%), corresponding product has
Preferable foam performance.But when calcium caseinate content be 6% or higher when, the viscosity of product is too big, can not it is filling and
Detection.
Embodiment 8-9
Dentifrice composition, the component content (weight %) and property of each product are similarly prepared according to the method for embodiment 1-4
Energy parameter is as shown in table 3.
Table 3
As a result：
As shown in table 3, the indices of the dentifrice composition of embodiment 8-9 meet the judgment criteria of toothpaste, are suitable as
It is used for toothpaste.Strawberry essence (being purchased from Guangzhou Man Ting fragrant materials Co., Ltd) used in embodiment 8-9 is soluble perfume.
In addition, as can be seen from Figure 2 compared to commercially available dentifrice composition, the dentifrice composition foaming of embodiment 8 and 9 is more
To be uniform, i.e., with better foam performance.From figure 3, it can be seen that the dentifrice composition of embodiment 8 has and commercially available toothpaste
The comparable clean-up performance of composition.
It will be clear for a person skilled in the art that many modifications and variations of the present invention can be carried out without departing from its spirit and model
It encloses.Specific embodiment as described herein is only provided by way of example, is not meant to limit in any way.The present invention
True scope and spirit show that description and embodiments are only exemplary by the appended claims.
Claims (8)
1. a kind of dentifrice composition, it includes the calcium caseinate based on the dentifrice composition total weight 0.05-5.5%,
Described in dentifrice composition substantially free of oil components.
2. the dentifrice composition of claim 1, wherein the total weight based on the dentifrice composition, the calcium caseinate contains
It measures as 1.5-4.5%.
3. the dentifrice composition of claims 1 or 2, wherein the dentifrice composition is also comprising at least one edible albumen.
4. the dentifrice composition of claim 3, wherein the edible eggs are selected from soybean protein, lactalbumin and egg white egg in vain
In vain.
5. the dentifrice composition of one of claim 3-4, wherein the total weight based on the dentifrice composition, calcium caseinate with
The total amount of edible albumen is 0.05-20%.
6. the dentifrice composition of one of claim 1-5, pH 5.5-10.0.
7. the dentifrice composition of one of claim 1-6, the surfactant substantially free of synthesis.
8. a kind of method for the dentifrice composition for preparing one of claim 1-7, the method includes being mixed in dentifrice composition
Close calcium caseinate or its mixture with edible albumen.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611270979.XA CN108261343A (en) | 2016-12-30 | 2016-12-30 | Foaming dentifrice composition based on protein |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611270979.XA CN108261343A (en) | 2016-12-30 | 2016-12-30 | Foaming dentifrice composition based on protein |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111920758A (en) * | 2020-09-23 | 2020-11-13 | 山东本真化妆品有限公司 | A foamable oral care composition free of surfactants |
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