CN108239151B - 重组单链人FVIII-Fc融合蛋白及其应用 - Google Patents
重组单链人FVIII-Fc融合蛋白及其应用 Download PDFInfo
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- CN108239151B CN108239151B CN201611203557.0A CN201611203557A CN108239151B CN 108239151 B CN108239151 B CN 108239151B CN 201611203557 A CN201611203557 A CN 201611203557A CN 108239151 B CN108239151 B CN 108239151B
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- fviii
- fusion protein
- chain
- human fviii
- recombinant single
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
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Abstract
Description
Claims (7)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611203557.0A CN108239151B (zh) | 2016-12-23 | 2016-12-23 | 重组单链人FVIII-Fc融合蛋白及其应用 |
PCT/CN2017/118099 WO2018113788A1 (zh) | 2016-12-23 | 2017-12-22 | 重组单链人FVIII-Fc融合蛋白及其应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201611203557.0A CN108239151B (zh) | 2016-12-23 | 2016-12-23 | 重组单链人FVIII-Fc融合蛋白及其应用 |
Publications (2)
Publication Number | Publication Date |
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CN108239151A CN108239151A (zh) | 2018-07-03 |
CN108239151B true CN108239151B (zh) | 2020-07-03 |
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CN201611203557.0A Active CN108239151B (zh) | 2016-12-23 | 2016-12-23 | 重组单链人FVIII-Fc融合蛋白及其应用 |
Country Status (2)
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CN (1) | CN108239151B (zh) |
WO (1) | WO2018113788A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN114989307B (zh) * | 2022-05-11 | 2023-08-01 | 华兰生物工程股份有限公司 | 一种重组人凝血因子Ⅷ-Fc融合蛋白及制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102791285A (zh) * | 2009-12-06 | 2012-11-21 | 比奥根艾迪克依蒙菲利亚公司 | 因子VIII-Fc嵌合多肽和杂交多肽及其使用方法 |
CN105143252A (zh) * | 2013-03-15 | 2015-12-09 | 豪夫迈·罗氏有限公司 | IL-22多肽和IL-22Fc融合蛋白及其使用方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US20020062010A1 (en) * | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
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2016
- 2016-12-23 CN CN201611203557.0A patent/CN108239151B/zh active Active
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2017
- 2017-12-22 WO PCT/CN2017/118099 patent/WO2018113788A1/zh active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102791285A (zh) * | 2009-12-06 | 2012-11-21 | 比奥根艾迪克依蒙菲利亚公司 | 因子VIII-Fc嵌合多肽和杂交多肽及其使用方法 |
CN105143252A (zh) * | 2013-03-15 | 2015-12-09 | 豪夫迈·罗氏有限公司 | IL-22多肽和IL-22Fc融合蛋白及其使用方法 |
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Publication number | Publication date |
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WO2018113788A1 (zh) | 2018-06-28 |
CN108239151A (zh) | 2018-07-03 |
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