CN108236694A - A kind of Chinese medicine composition for treating essential hypertension - Google Patents
A kind of Chinese medicine composition for treating essential hypertension Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compositions for treating essential hypertension, are as made from the raw material of following parts by weight：20 30 parts of Tamarix austro, 10 15 parts of wild country melon, 8 12 parts of Longtube Ground Ivy Herb, 68 parts of clearvers, 10 15 parts of chickweed, 14 16 parts of the tuber of stemona, 15 25 parts of the fruit of Chinese wolfberry, 10 20 parts of Bidens bipinnata, 59 parts of yellow cinnamon leaf, 10 12 parts of india lovegrass, 15 25 parts of Radix Codonopsis, 5 10 parts of phyllanthus amatusniruri, 5 10 parts of blue gum, 10 20 parts of rose, 10 20 parts of Radix Glycyrrhizae.The effect of all medicines of the present invention are instrumental ensembled, act synergistically, reach soothing the liver decompression, promoting blood circulation and removing blood stasis, enriching yin and nourishing kidney, inducing diuresis for treating strangurtia jointly has good therapeutic effect to essential hypertension.
Description
Technical field
The invention belongs to field of medicaments, and in particular to a kind of Chinese medicine composition for treating essential hypertension.
Background technology
By the standard of WHO, the blood pressure of human normal is systolic pressure ＜ 140mmHg and (or) diastolic pressure ＜ 90mmHg, is more than
This range can be diagnosed as hypertension.Hypertension is common angiocardiopathy, is defined as body and follows bad angiosthenia duration
Increase.High blood pressure secondary to kidney, endocrine and the nervous system disease is known as secondary hypertension disease, accounts for hypertensive patient's
5%~10%；And the high blood pressure of its reason is not yet illustrated so far, referred to as essential hypertension.Essential hypertension accounts for high blood
More than 90% patient is pressed, is often accompanied by the organ functionals such as fat and sugar metabolic disorder and the heart, brain, kidney and retina or device matter
It sexually revises, is cerebral apoplexy (cerebral infarction and cerebral hemorrhage), coronary heart disease, retinopathy, kidney damage (glomerulus infraction, renal failure)
Pathogenic factor, research shows that, the morbidity and mortality of cardiovascular and cerebrovascular disease and blood pressure to increase degree closely related.
The traditional Chinese medical science thinks that hypertension belongs to the scopes such as " dizziness ", " headache ", " liver wind ", " wind is dizzy ", similar in traditional Chinese medical science books
Or similar symptom, case taking can come therewith it is corresponding.And for the interpretation of the cause, onset and process of an illness of this disease《, Plain Questions is to will very discuss greatly》It points out
" all wind falls string, comes under liver ", Liu Wansu is at it《The former sick formula of the Plain Questions interpretation of the cause, onset and process of an illness》Wind fire is proposed in one book and leads to string, " wind fire is all
Belong to sun, mostly simultaneousization, sun is main dynamic, and two is dynamic mutually rich, then rotates for it, ZHU Dan-xi is at it《Danxi's experiential therapy head string》In think
" no tired do not make string " thinks that " head string, the empty simultaneously fire of phlegm gas enclosure, controls based on phlegm, press from both sides Qi-tonifying drug and fall fire medicine.No phlegm does not make string then,
Phlegm is dynamic because of fire ", Ming Dynasty's Zhang Jingyue emphasizes the thinking of " no void does not make string " again, speaks approvingly of:It " when to control based on void, and drinks and its mark.
Golden Li Dong Yuan controls string and swoons from empty phlegm opinion, it is believed that and it is deficiency of spleen-QI and stomach-QI, transporting mistake department, raw in phlegm wet, the position of clear sun is violated on the phlegm of pond and is seen
String is swooned,《The secret record of the orchid chamber is had a headache》Described in say that " nausea and vomiting are not eaten, and phlegm saliva is sticky, and the rotation of pupil head, mesh cannot open, such as
In wind and cloud ", as deficiency of spleen-QI and stomach-QI, phlegm oil superinverse string swoon, banxia baizhu tianma decoction is selected in treatment.Song Sun Yun is virtuous to be thought
It is physically weak, it is damaged especially with liver kidney deficiency, it is in addition inside and outside, not inside and outside three because being hindered, it is that string is swooned the synthesis cause of disease of morbidity,《Hospital is big
Into》Described in " though《Through》Cloud ' all wind falls string, comes under liver ' is attacked and string is caused to swoon on liver wind, so physically weak people or be outside wind,
Cold, heat, wet gas do, are inside tied by the gas of seven feelings, strongly fragrant and give birth to saliva, and can all make us a period of time string swoons, upper excess and lower deficiency, golden to spit bitterly
Brain, facility hyperhematosis and married woman is gone to collapse wound, all can string swoon.
Doctor trained in Western medicine research thinks that essential hypertension is heredity, environment, anatomical structure, adaptability, nerve, endocrine, body fluid
With haemodynamics various aspects comprehensive function as a result, being a kind of certain congenital hereditary genes and many pathogenic supercharging factors
Multi-factor disease caused by factor interaction is depressurized with physiological.Except foreign genetic element, the low potassium diet of high sodium, drink in life
The poor eating habits such as wine and overweight, fat, long-term nervous, shortage movement etc. are it is possible that induce hypertension.So
Clinically the outer cooperation between non-drug therapy of drug therapy is focused in the treatment of hypertension, that is, focuses on lifestyle modification and drop
Press the cooperation between drug therapy.The antihypertensive drugs that doctor trained in Western medicine clinic is often applied mainly has the calcium ion antagonist (CaA), blood vessel tight
Plain converting enzyme inhibitor (ACEI), β bodies retarding agent, diuretics this four class, secondly also have C receptor blocker, vasodilator
Usually can all have a larger side effect Deng, these drugs, price also costly, the tolerance of Drug safety and patient
And compliance is to be improved.
Medical field thinks at present, and essential hypertension is a lifelong disease, and not yet report has any drug thorough at present
Hypertension is cured, patient need to take anti-hypertension treatment for a long time.Antihypertensive drugs needs long-term or lifelong application, the peace of drug
Full property and the tolerance of patient are particularly significant, and Traditional Chinese Medical on Treating Hypertension drug side-effect is small and efficacy stability, can long-term safety use
Medicine has a extensive future, but the Chinese medicine of existing prevention and treatment hypertension is not notable there are effect, works the deficiencies of slow, seeks one kind
Significant effect, rapid-action, convenient to take Chinese medicine preparation have great importance to the clinical treatment of essential hypertension.
Invention content
The present invention provides a kind of decompression of soothing the liver, promoting blood circulation and removing blood stasis, enriching yin and nourishing kidney, inducing diuresis for treating strangurtia treatment essential hypertension
Chinese medicine composition.
The purpose of the present invention is what is be achieved through the following technical solutions：
A kind of Chinese medicine composition for treating essential hypertension is as made from the raw material of following parts by weight：Tamarix austro 20-
30 parts, melon 10-15 parts of wild country, 8-12 parts of Longtube Ground Ivy Herb, 6-8 parts of clearvers, 10-15 parts of chickweed, 14-16 parts of the tuber of stemona, fruit of Chinese wolfberry 15-
25 parts, it is 10-20 parts of Bidens bipinnata, 5-9 parts of yellow cinnamon leaf, 10-12 parts of india lovegrass, 15-25 parts of Radix Codonopsis, 5-10 parts of phyllanthus amatusniruri, blue
5-10 parts of eucalyptus, 10-20 parts of rose, 10-20 parts of Radix Glycyrrhizae.
Preferably, a kind of Chinese medicine composition for treating essential hypertension is as made from the raw material of following parts by weight：It is sweet
25 parts of akebi, 13 parts of wild country melon, 10 parts of Longtube Ground Ivy Herb, 7 parts of clearvers, 12 parts of chickweed, 15 parts of the tuber of stemona, 20 parts of the fruit of Chinese wolfberry, Bidens bipinnata
15 parts, 7 parts of yellow cinnamon leaf, 11 parts of india lovegrass, 20 parts of Radix Codonopsis, 8 parts of phyllanthus amatusniruri, 7 parts of blue gum, 15 parts of rose, 15 parts of Radix Glycyrrhizae.
The Chinese medicine composition of present invention treatment essential hypertension is prepared by following methods：
1) following raw material is weighed by weight：Tamarix austro, wild country melon, Longtube Ground Ivy Herb, clearvers, chickweed, the tuber of stemona, matrimony vine
Son, Bidens bipinnata, yellow cinnamon leaf, india lovegrass, Radix Codonopsis, phyllanthus amatusniruri, blue gum, rose and Radix Glycyrrhizae crush, and add in medicinal material total weight
The 6-8 times of water measured impregnates 10-20min, and refluxing extraction 3 times, each 1-3h filters and retains filter residue, and merging filtrate obtains water and carries
Liquid；
2) filter residue is added in the ethyl alcohol of 1-2 times of medicinal material total weight, refluxing extraction 2-3 times, each 1-3h, filtering, merging filter
Liquid obtains alcohol extract；
3) Aqueous extracts and alcohol extract are uniformly mixed, vacuum belt type drying, dry pressure is carried out at a temperature of resting on 50-60 DEG C
Power is -0.09MPa, and charging rate 14-16L/h, material strip transmission speed is 20-28cm/min, obtains dry extract；By dry extract
100-200 mesh sieve is crossed after broken, you can the Chinese medicine composition of present invention treatment essential hypertension is made.
Using modern general preparation technique, the Chinese medicine composition of present invention treatment essential hypertension can be made into clinical need
The finished product preparation wanted, such as granule, pill, powder, tablet or capsule dosage form.
The pharmacology of each bulk pharmaceutical chemicals is as follows：
Tamarix austro：It is sweet in flavor, slightly cool in nature.Converge to heart and liver channels.Clearing away the liver-fire, calming heart god, blood pressure lowering are removed obstruction in channels to relieve pain.
Wild country melon：Wind-damp dispelling, only degrading the channel, leukorrhea.For chronic bronchitis, rheumatism arthralgia and myalgia, diarrhea, dysentery,
Mastitis, oedema, irregular menstruation, puerperal abdominalgia with blood stasis, have blood in stool, nose is bleeding, scrofula, synthetism, traumatic injury, knife wound, mad dog are bitten,
Carbuncle swells, impetigo, venomous snake bite.
Longtube Ground Ivy Herb：Acrid flavour, slight bitter, cold nature.Return liver, kidney, bladder warp.Dampness removing is treating stranguria, clearing heat and detoxicating, eliminating stasis to subdue swelling.With
In heat gonorrhea, urolithiasis, jaundice with damp-heat pathogen, sore, carbuncle and painful swelling, traumatic injury.
Clearvers：Acrid flavour, hardship, it is cool in nature.It is clearing heat and detoxicating, inducing diuresis to remove edema.Flu, bleeding gums, acute and chronic appendicitis are secreted
The infection of urine system, oedema, dysmenorrhoea, uterine bleeding, leukorrhea, cancer, leukaemia；External application controls mastitis from the beginning of, carbuncle furuncle poison, traumatic injury.
Chickweed：It is sweet in flavor, sour, it is cool in nature.It is clearing heat and detoxicating, blood-activating analgetic, lactagogue.For enteritis, dysentery, hepatitis, appendicitis, production
Abdominal pain due to blood stasis afterwards, uterine contractile pain, toothache, graying of hair, agalactia, mastitis, traumatic injury, sore swollen toxin.
The tuber of stemona：Slightly warm in nature is sweet in flavor, bitter.Moistening lung to lower qi cough-relieving, desinsection.It coughs for new chronic cough, pulmonary tuberculosis cough, pertussis, outside
For head louse, private parts, which is disturbed, itches.
The fruit of Chinese wolfberry：It is sweet in flavor, it is mild-natured.Return liver and kidney channel.It is nourishing liver and kidney, benefiting shrewd head.For syndrome of yin deficiency of liver and kidney.
Bidens bipinnata：Bitter, it is mild-natured.Return lung, spleen, stomach, large intestine channel.It is clearing heat and detoxicating, promoting blood circulation and stopping pain.For cold, fever, pharynx
Bitterly, acute appendicitis, jaundice, malaria, venomous snake bite etc..
Yellow cinnamon leaf：Taste micro-pungent, it is warm-natured.Dehumidifying, analgesic, desinsection.Control treating rheumatic ostealgia, traumatic injury, mange.
India lovegrass：It is sweet in flavor, light, it is cool in nature.Inducing diuresis for treating strangurtia, heat clearing and blood circulation promoting.For heat gonorrhea, urolithiasis, hot eyes is itched bitterly, bruise damage
Wound.
Radix Codonopsis：It is sweet in flavor, it is mild-natured.There is tonifying middle-Jiao and Qi, quench the thirst, strengthening spleen and tonifying lung, nourishes blood and promotes the production of body fluid.For spleen-lung Qi deficiency, deficiency of food is tired
It is idle, false asthma cough, insufficiency of vital energy and blood, sallow complexion, palpitation, injury thirst, Heat Diabetes.
Phyllanthus amatusniruri：It is mildly bitter flavor, sweet, it is cool in nature.Reducing fever and causing diuresis, improving eyesight, disperse accumulation.For nephritic dropsy, urinary infection,
Calculus, enteritis, dysentery, small two infantile malnutrition due to digestive disturbances or intestinalparasites, eye keratitis, icteric hepatitis
Blue gum：Taste micro-pungent, slight bitter, it is mild-natured.Dispelling wind is antipyretic, inhibiting bacteria and diminishing inflammation, and anti-corrosion is antipruritic.For prevent influenza,
Meningococal meningitis controls the infection of the upper respiratory tract, sphagitis, bronchitis, pneumonia, Acute and chronic pyelonephritis, enteritis, dysentery
Disease, filariasis.
Rose：Sweet in flavor, slight bitter, slightly warm in nature.Return liver, spleen, stomach.Vital energy regualting and blood circulation-promoting, soothing liver-qi stagnation, have it is calm, pacify,
The effect of anti-melancholy.
Radix Glycyrrhizae：The thoughts of returning home, lung, spleen, stomach.Invigorating middle warmer and replenishing QI, clearing heat and detoxicating, expelling phlegm and arresting coughing alleviate analgesic, mediation property of medicine.
In the present invention, Tamarix austro and rose are monarch drug in a prescription, and soothing the liver decompression, soothing liver-qi stagnation adjust the dirty negative and positive of qi and blood of bushing, enhancing
Cardiac contractile force；Wild country melon, Longtube Ground Ivy Herb, the fruit of Chinese wolfberry and Radix Codonopsis are ministerial drug, and heat-clearing decompression, enriching yin liver kidney, inducing diuresis for treating strangurtia alleviate blood
Pipe spasm, significantly reduces capillary permeability, increases its tension, blood pressure is made steadily to decline；Clearvers, chickweed, Bidens bipinnata and
Phyllanthus amatusniruri is adjutant, promoting blood circulation and removing blood stasis, dampness elimination row water, analgesic heat dissipation；The tuber of stemona, yellow cinnamon leaf, india lovegrass, blue gum and Radix Glycyrrhizae are altogether
Make medicine, dispelling wind is antipyretic, regulating qi-flowing for relieving pain, and coordinating the drug actions of a prescription.All medicines are instrumental ensembled, synergistic effect, reach soothing the liver decompression, promoting blood circulationization jointly
The effect of stasis of blood, enriching yin and nourishing kidney, inducing diuresis for treating strangurtia, has good therapeutic effect to essential hypertension.
Specific embodiment
In order to be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, tie below
Specific example is closed, the present invention is further explained.
Embodiment 1
A kind of Chinese medicine composition for treating essential hypertension is as made from the raw material of following parts by weight：Tamarix austro 25
Part, 13 parts of wild country melon, 10 parts of Longtube Ground Ivy Herb, 7 parts of clearvers, 12 parts of chickweed, 15 parts of the tuber of stemona, 20 parts of the fruit of Chinese wolfberry, 15 parts of Bidens bipinnata, perfume
7 parts of camphor tree leaf, 11 parts of india lovegrass, 20 parts of Radix Codonopsis, 8 parts of phyllanthus amatusniruri, 7 parts of blue gum, 15 parts of rose, 15 parts of Radix Glycyrrhizae.
The Chinese medicine composition of present invention treatment essential hypertension is prepared by following methods：
1) following raw material is weighed by weight：Tamarix austro, wild country melon, Longtube Ground Ivy Herb, clearvers, chickweed, the tuber of stemona, matrimony vine
Son, Bidens bipinnata, yellow cinnamon leaf, india lovegrass, Radix Codonopsis, phyllanthus amatusniruri, blue gum, rose and Radix Glycyrrhizae crush, and add in medicinal material total weight
The water of 7 times of amounts impregnates 15min, and refluxing extraction 3 times, each 2h filters and retains filter residue, merging filtrate obtains Aqueous extracts；
2) filter residue is added in the ethyl alcohol of 2 times of medicinal material total weight, refluxing extraction 3 times, each 2h filters, and merging filtrate obtains alcohol
Extract；
3) Aqueous extracts and alcohol extract are uniformly mixed, vacuum belt type drying, drying pressure is carried out at a temperature of resting on 55 DEG C
For -0.09MPa, charging rate 15L/h, material strip transmission speed is 24cm/min, obtains dry extract；Dry extract is smashed it through
150 mesh sieve, you can the Chinese medicine composition of present invention treatment essential hypertension is made.
Using modern general preparation technique, the Chinese medicine composition of present invention treatment essential hypertension can be made into clinical need
The finished product preparation wanted, such as granule, pill, powder, tablet or capsule dosage form.
Embodiment 2
A kind of Chinese medicine composition for treating essential hypertension is as made from the raw material of following parts by weight：Tamarix austro 20
Part, 15 parts of wild country melon, 8 parts of Longtube Ground Ivy Herb, 8 parts of clearvers, 15 parts of chickweed, 16 parts of the tuber of stemona, 25 parts of the fruit of Chinese wolfberry, 10 parts of Bidens bipinnata, perfume
5 parts of camphor tree leaf, 12 parts of india lovegrass, 25 parts of Radix Codonopsis, 5 parts of phyllanthus amatusniruri, 10 parts of blue gum, 10 parts of rose, 20 parts of Radix Glycyrrhizae.
The Chinese medicine composition of present invention treatment essential hypertension is prepared by following methods：
1) following raw material is weighed by weight：Tamarix austro, wild country melon, Longtube Ground Ivy Herb, clearvers, chickweed, the tuber of stemona, matrimony vine
Son, Bidens bipinnata, yellow cinnamon leaf, india lovegrass, Radix Codonopsis, phyllanthus amatusniruri, blue gum, rose and Radix Glycyrrhizae crush, and add in medicinal material total weight
The water of 6 times of amounts impregnates 20min, and refluxing extraction 3 times, each 1h filters and retains filter residue, merging filtrate obtains Aqueous extracts；
2) filter residue is added in the ethyl alcohol of 2 times of medicinal material total weight, refluxing extraction 3 times, each 1h filters, and merging filtrate obtains alcohol
Extract；
3) Aqueous extracts and alcohol extract are uniformly mixed, vacuum belt type drying, drying pressure is carried out at a temperature of resting on 60 DEG C
For -0.09MPa, charging rate 14L/h, material strip transmission speed is 20cm/min, obtains dry extract；Dry extract is smashed it through
100 mesh sieve, you can the Chinese medicine composition of present invention treatment essential hypertension is made.
Using modern general preparation technique, the Chinese medicine composition of present invention treatment essential hypertension can be made into clinical need
The finished product preparation wanted, such as granule, pill, powder, tablet or capsule dosage form.
Embodiment 3
A kind of Chinese medicine composition for treating essential hypertension is as made from the raw material of following parts by weight：Tamarix austro 23
Part, 14 parts of wild country melon, 9 parts of Longtube Ground Ivy Herb, 7 parts of clearvers, 13 parts of chickweed, 15 parts of the tuber of stemona, 23 parts of the fruit of Chinese wolfberry, 13 parts of Bidens bipinnata, perfume
7 parts of camphor tree leaf, 11 parts of india lovegrass, 23 parts of Radix Codonopsis, 6 parts of phyllanthus amatusniruri, 9 parts of blue gum, 13 parts of rose, 18 parts of Radix Glycyrrhizae.
The Chinese medicine composition of present invention treatment essential hypertension is prepared by following methods：
1) following raw material is weighed by weight：Tamarix austro, wild country melon, Longtube Ground Ivy Herb, clearvers, chickweed, the tuber of stemona, matrimony vine
Son, Bidens bipinnata, yellow cinnamon leaf, india lovegrass, Radix Codonopsis, phyllanthus amatusniruri, blue gum, rose and Radix Glycyrrhizae crush, and add in medicinal material total weight
The water of 7 times of amounts impregnates 15min, and refluxing extraction 3 times, each 2h filters and retains filter residue, merging filtrate obtains Aqueous extracts；
2) filter residue is added in the ethyl alcohol of 1 times of medicinal material total weight, refluxing extraction 2 times, each 2h filters, and merging filtrate obtains alcohol
Extract；
3) Aqueous extracts and alcohol extract are uniformly mixed, vacuum belt type drying, drying pressure is carried out at a temperature of resting on 55 DEG C
For -0.09MPa, charging rate 15L/h, material strip transmission speed is 22cm/min, obtains dry extract；Dry extract is smashed it through
150 mesh sieve, you can the Chinese medicine composition of present invention treatment essential hypertension is made.
Using modern general preparation technique, the Chinese medicine composition of present invention treatment essential hypertension can be made into clinical need
The finished product preparation wanted, such as granule, pill, powder, tablet or capsule dosage form.
Embodiment 4
A kind of Chinese medicine composition for treating essential hypertension is as made from the raw material of following parts by weight：Tamarix austro 28
Part, 12 parts of wild country melon, 11 parts of Longtube Ground Ivy Herb, 7 parts of clearvers, 11 parts of chickweed, 15 parts of the tuber of stemona, 18 parts of the fruit of Chinese wolfberry, 18 parts of Bidens bipinnata, perfume
7 parts of camphor tree leaf, 11 parts of india lovegrass, 18 parts of Radix Codonopsis, 9 parts of phyllanthus amatusniruri, 6 parts of blue gum, 18 parts of rose, 13 parts of Radix Glycyrrhizae.
The Chinese medicine composition of present invention treatment essential hypertension is prepared by following methods：
1) following raw material is weighed by weight：Tamarix austro, wild country melon, Longtube Ground Ivy Herb, clearvers, chickweed, the tuber of stemona, matrimony vine
Son, Bidens bipinnata, yellow cinnamon leaf, india lovegrass, Radix Codonopsis, phyllanthus amatusniruri, blue gum, rose and Radix Glycyrrhizae crush, and add in medicinal material total weight
The water of 7 times of amounts impregnates 15min, and refluxing extraction 3 times, each 2h filters and retains filter residue, merging filtrate obtains Aqueous extracts；
2) filter residue is added in the ethyl alcohol of 1 times of medicinal material total weight, refluxing extraction 2 times, each 2h filters, and merging filtrate obtains alcohol
Extract；
3) Aqueous extracts and alcohol extract are uniformly mixed, vacuum belt type drying, drying pressure is carried out at a temperature of resting on 55 DEG C
For -0.09MPa, charging rate 15L/h, material strip transmission speed is 26cm/min, obtains dry extract；Dry extract is smashed it through
150 mesh sieve, you can the Chinese medicine composition of present invention treatment essential hypertension is made.
Using modern general preparation technique, the Chinese medicine composition of present invention treatment essential hypertension can be made into clinical need
The finished product preparation wanted, such as granule, pill, powder, tablet or capsule dosage form.
Embodiment 5
A kind of Chinese medicine composition for treating essential hypertension is as made from the raw material of following parts by weight：Tamarix austro 30
Part, 10 parts of wild country melon, 12 parts of Longtube Ground Ivy Herb, 6 parts of clearvers, 10 parts of chickweed, 14 parts of the tuber of stemona, 15 parts of the fruit of Chinese wolfberry, 20 parts of Bidens bipinnata, perfume
9 parts of camphor tree leaf, 10 parts of india lovegrass, 15 parts of Radix Codonopsis, 10 parts of phyllanthus amatusniruri, 5 parts of blue gum, 20 parts of rose, 10 parts of Radix Glycyrrhizae.
The Chinese medicine composition of present invention treatment essential hypertension is prepared by following methods：
1) following raw material is weighed by weight：Tamarix austro, wild country melon, Longtube Ground Ivy Herb, clearvers, chickweed, the tuber of stemona, matrimony vine
Son, Bidens bipinnata, yellow cinnamon leaf, india lovegrass, Radix Codonopsis, phyllanthus amatusniruri, blue gum, rose and Radix Glycyrrhizae crush, and add in medicinal material total weight
The water of 8 times of amounts impregnates 10min, and refluxing extraction 3 times, each 3h filters and retains filter residue, merging filtrate obtains Aqueous extracts；
2) filter residue is added in the ethyl alcohol of 2 times of medicinal material total weight, refluxing extraction 3 times, each 3h filters, and merging filtrate obtains alcohol
Extract；
3) Aqueous extracts and alcohol extract are uniformly mixed, vacuum belt type drying, drying pressure is carried out at a temperature of resting on 50 DEG C
For -0.09MPa, charging rate 16L/h, material strip transmission speed is 28cm/min, obtains dry extract；Dry extract is smashed it through
200 mesh sieve, you can the Chinese medicine composition of present invention treatment essential hypertension is made.
Using modern general preparation technique, the Chinese medicine composition of present invention treatment essential hypertension can be made into clinical need
The finished product preparation wanted, such as granule, pill, powder, tablet or capsule dosage form.
Pharmacodynamic study
Experimental animal：10 week old Wistar-Kyoto rats 10 of normal health, cleaning grade, weight 190-210g are male
Property, it is set as Normal group.Original hypertensive rat (SHR) 50, cleaning grade, 10 week old, weight 200-240g, male,
It is randomly divided into 5 groups, every group 10.
Trial drug and dosage regimen：It is divided into drug test group of the present invention, model control group, positive controls and normal right
According to group.
Drug test group of the present invention：Chinese medicine of the trial drug for the treatment essential hypertension obtained of the embodiment of the present invention 1
The tablet of composition is deployed into the solution of a concentration of 0.6g/ml, 0.4g/ml and 0.2g/ml with water after grinding, spare.Take 3 groups
Original hypertensive rat, labeled as high dose group (dosage 1.2g/kg), middle dose group (dosage 0.8g/kg) and low dose group
(dosage 0.4g/kg), the drug solution of a concentration of 0.6g/ml of high dose group, the drug of a concentration of 0.4g/ml of middle dose group
Solution, the drug solution of a concentration of 0.2g/ml of high dose group, according to dosage early daily, late each gastric infusion is primary, successive administration
20 days.
Positive controls：Positive control drug is kendir pressure-reducing piece (Chinese medicines quasi-word Z20093153, Harbin Pharmaceutical Group's Chinese medicine two
Factory), the solution of 0.6g/ml is deployed into after grinding with water, takes 1 group of original hypertensive rat, it is daily by the dosage of 1.2g/kg
Early, late each gastric infusion is primary, successive administration 20 days.
Model control group：1 group of original hypertensive rat is taken, isometric(al) physiological saline is early daily, evening each gavage is primary, even
Continuous administration 20 days.
Normal group：Isometric(al) physiological saline is early daily, evening each gavage is primary, successive administration 20 days.
The measure of blood pressure and heart rate：Before first gastric infusion after 2h and last dose 2h, the arteria caudalis of each group rat is measured
Systolic pressure and heart rate.Rat is put into preheating 15min in (37 ± 1) DEG C electrothermostat before pressure measurement, when pressure measurement, continuously surveys 3 times,
It is averaged as measured value.
Result of the test：As shown in table 1.
1 each group rat tail artery systolic pressure of table changes
Note：Compared with Normal group, model control group * P ＞ 0.05, * * P ＞ 0.01；Compared with model control group, medicine
0.05 , ＆＆P ＜ 0.01 of object Shi Yanzu ＆P ＜；Compared with positive controls, drug test group #P ＜ 0.05, ##P ＜ 0.01.
Conclusion：As shown in Table 1, the Chinese medicine composition of present invention treatment essential hypertension can significantly reduce the high blood of primary
The blood pressure (P ＜ 0.01) of rat model is pressed, and the middle dose group of Chinese medicine composition of the present invention and the antihypertensive effect of high dose group are equal
It is significantly better than positive controls.Meanwhile Chinese medicine composition of the present invention is also equipped with slowing down essential hypertension rat model heart rate
Effect, low dose group is suitable with positive controls with the effect of middle dose group, the function and effect and positive controls of high dose group
Compare the difference with conspicuousness.
Clinical test
1. diagnostic criteria：Reference《Chinese hypertension prevention and control guide》(revised edition in 2010) and《New Chinese medicine clinical research
Guideline》The content of " diagnosis basis of high blood pressure " draft.
2. Western medicine diagnostic criteria：As shown in table 2.
2 doctor trained in Western medicine blood pressure level of table defines and classification
In the case where antihypertensive drugs is not used, non-3 measurement blood pressures on the same day, systolic pressure >=140mmHg and/or diastolic pressure
>=90mmHg, you can be diagnosed as essential hypertension.
3. TCM syndrome diagnostic criteria：
1) overabundant liver-fire disease
Primary symptom：Dizziness, headache, being irritable and getting angry easily.
Minor symptom：Flushing, hot eyes, dry, bitter taste, constipation, urinate red, red tongue with yellowish fur, wiry and frequent pulse.
2) hyperactivity of yang due to yin deficiency disease
Primary symptom：Dizziness, headache, the soreness of waist, knee are soft, dysphoria in chestpalms-soles.
Minor symptom：Palpitaition, insomnia, tinnitus, the red few tongue of forgetful, tongue, small and wiry pulse and count.
3) phlegm wet, which is stopped up, contains disease
Primary symptom：Dizziness, headache, head are such as wrapped up in, are uncomfortable in chest, vomitting phlegm birth.
Minor symptom：Palpitaition, insomnia, mouth are light, deficiency of food, the fat tongue of tongue are greasy, slippery.
4) yin-yang deficiency disease
Primary symptom：Dizziness, headache, the soreness of waist, knee are soft, aversion to cold and cold limbs.
Minor symptom：Tinnitus, palpitaition, shortness of breath, enuresis nocturna frequency, pale tongue with white fur, deeptensepulse are thin and delicate.
Meet high blood pressure Western medicine diagnostic criteria and TCM syndrome diagnostic criteria, the age between 18~65 years old, non-medication,
Or take hypertension drug but be discontinued after two weeks, informed consent form person is obtained, experiment case can be included in.
4. exclude and reject case standard：
1) secondary hypertension；
2) age is in under-18s or over-65s, the gestational period or women breast-feeding their children or those who are allergic to this drug；
3) the severe primaries diseases such as cardiovascular and cerebrovascular, liver kidney and hemopoietic system, mental patient are associated with；
4) do not meet inclusion criteria, not by regulation medication, can not judge that curative effect or data do not affect the treatment or safety entirely
Judgement person.
5. general information：300 clinical aspirations for meeting essential hypertension diagnostic criteria are obtained by diagnosis standard screening
Person patient, man 152, female 148, age 31-65 Sui, average age 52 years old.By random, double blind, parallel, control principle point
Into six groups for the treatment of A groups, treatment B groups, treatment C groups, treatment D groups, treatment E groups and control group, every group each 50, two groups of patients are in property
Not, the influence factors such as age, disease, state of an illness distribution, are statistically analyzed, there was no significant difference, meets grouping condition.
6. trial drug and test method：
Treatment group：1-5 of the embodiment of the present invention prepares the tablet of the Chinese medicine composition for the treatment of essential hypertension, respectively as
Treat the trial drug of A, B, C, D, E group.Therapeutic modality for one time 4, three times a day, as a treatment course with 4 weeks, 3 courses for the treatment of
After evaluate curative effect.
Control group：Control drug is kendir pressure-reducing piece (Chinese medicines quasi-word Z20093153, No. 2 TCM Factory), is controlled
The same treatment group for the treatment of mode.
7. curative effect determinate standard
It is effective：1) more than diastole drops 10mmHg, and reach normal range (NR)；2) under though diastolic pressure does not drop to normally but
20mmHg or more drops.Must have wherein 1.
Effectively：1) diastole drops are not as good as 10mmHg, but have reached normal range (NR)；2) diastolic pressure relatively treat before decline 10~
19mmHg, but not up to normal range (NR)；3) decline more than 30mmHg before systolic pressure is relatively treated.Must have wherein 1.
In vain：More than standard person is not reached.
8. treatment results：As shown in table 3.
3 therapeutic effect of table
As shown in Table 3, the Chinese medicine composition of present invention treatment essential hypertension is for essential hypertension therapeutic effect
Significantly, average obvious effective rate is 68.8%, and average total effective rate is 95.2%, is significantly higher than control group.
The basic principles, main features and the advantages of the invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its
Equivalent thereof.
Claims (2)
1. a kind of Chinese medicine composition for treating essential hypertension, which is characterized in that be as made from the raw material of following parts by weight：
20-30 parts of Tamarix austro, melon 10-15 parts of wild country, 8-12 parts of Longtube Ground Ivy Herb, 6-8 parts of clearvers, 10-15 parts of chickweed, 14-16 parts of the tuber of stemona,
15-25 parts of the fruit of Chinese wolfberry, 10-20 parts of Bidens bipinnata, 5-9 parts of yellow cinnamon leaf, 10-12 parts of india lovegrass, 15-25 parts of Radix Codonopsis, phyllanthus amatusniruri
5-10 parts, 5-10 parts of blue gum, 10-20 parts of rose, 10-20 parts of Radix Glycyrrhizae.
2. the Chinese medicine composition of essential hypertension is treated according to claim 1, which is characterized in that be by following parts by weight
Raw material made from：25 parts of Tamarix austro, 13 parts of wild country melon, 10 parts of Longtube Ground Ivy Herb, 7 parts of clearvers, 12 parts of chickweed, 15 parts of the tuber of stemona, Chinese holly
20 parts of matrimony vine, 15 parts of Bidens bipinnata, 7 parts of yellow cinnamon leaf, 11 parts of india lovegrass, 20 parts of Radix Codonopsis, 8 parts of phyllanthus amatusniruri, 7 parts of blue gum, rose
Spend 15 parts, 15 parts of Radix Glycyrrhizae.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104984097A (en) * | 2015-08-10 | 2015-10-21 | 青岛蓝盛洋医药生物科技有限责任公司 | Chinese herba preparation for treating primary hypertension and application thereof |
| CN105194355A (en) * | 2015-11-12 | 2015-12-30 | 青岛华之草医药科技有限公司 | Traditional Chinese medicine preparation for treating primary hypertension |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104984097A (en) * | 2015-08-10 | 2015-10-21 | 青岛蓝盛洋医药生物科技有限责任公司 | Chinese herba preparation for treating primary hypertension and application thereof |
| CN105194355A (en) * | 2015-11-12 | 2015-12-30 | 青岛华之草医药科技有限公司 | Traditional Chinese medicine preparation for treating primary hypertension |
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Application publication date: 20180703 |