CN108210588A - A kind of pharmaceutical composition and preparation method with tranquilizing effect - Google Patents
A kind of pharmaceutical composition and preparation method with tranquilizing effect Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a kind of pharmaceutical composition and preparation method with effects of tranquilizing and allaying excitement, which is made of the bulk pharmaceutical chemicals of following weight ratio：4~30 parts of wilsonii, 3~25 parts of spina date seed, 3~25 parts of Schisandra chinensis, 3~25 parts of Radix Polygalae, 2~12 parts of the seed of Oriental arborvitae.Pharmaceutical composition of the present invention has effects that tranquilizing and allaying excitement, has preferable prophylactic treatment effect to insomniac.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition with treatment or health-care efficacy, more particularly, to a kind of energy tranquilizing and allaying excitement
Pharmaceutical composition and preparation method.
Background technology
Insomnia is also known as insomnia, must not sleep, insomnia etc., be by it is regular cannot obtain ortho characterized by a kind of disease
Card, clinical manifestation is difficulty falling asleep, awakens often or cannot be slept again after waking up；Morning wakes up too early；Night cannot sleep；Sleeping time is less than 5
Hour, it is often accompanied by the syndromes groups such as palpitaition, dreaminess, forgetful, decrease of memory, seminal emission and irregular menstruation.The whole world about 30% according to statistics
Crowd have a dyscoimesis, about more than 10% there are chronic insomnias.China's recent statistics show, insomnia incidence be up to 40% with
On, it has severely compromised the physical and mental health of people.Though western medicine is significant in efficacy, easily occur it is dizzy, drowsiness, weak and
Stupor and the adverse reactions such as respiration inhibition, long-time service can also generate tolerance, dependence and additive.And the traditional Chinese medical science is in dialectical opinion
On the basis of controlling to insomnia card treatment, have it is significant in efficacy, have no toxic side effect, the advantage of no drug dependence.Therefore, it has a sleepless night
The Chinese medicine study of card is the research hotspot of numerous scholars in recent years.
Chinese patent ZL201210300676.3 discloses a kind of traditional Chinese herbal decoction for treating insomnia, which is by Radix Codonopsis 13
~18, rhizoma atractylodis macrocephalae 13~18 fries rhizoma atractylodis 17~23, Poria cocos 17~23, eupatorium 12~16, the Bi roots of grass 3~7, gingko benevolence 3~7, wild jujube
Core 18~25, the seed of Oriental arborvitae 13~17, Polygonum multiflower knotweed 28~34, Flos Albiziae 10~14, Radix Curcumae 14~16, giant knotweed 14~16, semen armeniacae amarae 8
~11, White Chloe 10~13, adlay 28~34, rhizoma pinellinae praeparata 8~12, Cortex Magnoliae Officinalis 8~12, Semen Nelumbinis 13~17, Radix Polygalae 16~20 and wheat
Winter 7~10 forms.Chinese patent ZL201510847220.2 discloses a kind of Chinese medicine for improving sleep-disorder, which includes remote
15-30 parts of will, 10-20 parts of corydalis tuber, 20-30 parts of Schisandra chinensis, 20-40 parts of moutan bark, 10-20 parts of Radix Glycyrrhizae, 10-20 parts of safflower.
Chinese patent ZL201510640862.5 discloses a kind of Chinese medicine for improving sleep, is made of the raw material of following parts by weight：Wild spirit
1~5 part of sesame, 5~10 parts of matrimony vine, 3~8 parts of fructus gardeniae, 2~5 parts of Schisandra chinensis, 4~15 parts of Chinese ephedra, 7~15 parts of Rhizoma Atractylodis Macrocephalae, Tabasheer
1~8 part, 5~15 parts of rhizoma anemarrhenae, 2~8 parts of the stem of noble dendrobium, 5~10 parts of the seed of Oriental arborvitae, 10~20 parts of HERBA EPIMEDII, 3~7 parts of Radix Aucklandiae, sowthistle 1
~3 parts, 6~12 parts of raw lily, 10~15 parts of honeysuckle, 10~25 parts of wild chrysanthemum, 12~20 parts of Jasmine, felwort 3~8
Part, 6~10 parts of common perilla, 5~12 parts of radix polygonati officinalis, 3~12 parts of the fruit of summer cypress, 2~6 parts of Tu silks, 5~20 parts of Asiatic plantain, Radix Glycyrrhizae 2~10
Part.Although above-mentioned patent has insomnia preferable therapeutic effect, the drug included in above-mentioned patent is more, is industrializing
It is difficult to control its impurity content during production, is difficult to realize industrialized production.
Invention content
Of the existing technology to solve the problems, such as, the present invention provides a kind of composition simply, and novel formula is lost for treating
The pharmaceutical composition of dormancy, the pharmaceutical composition have the advantages that at low cost, good effect, have no toxic side effect, can be used for a long time.
The purpose of the present invention is achieved through the following technical solutions：
A kind of pharmaceutical composition with tranquilizing effect, the pharmaceutical composition are made of the raw material of following parts by weight：
4~30 parts of wilsonii, 3~25 parts of spina date seed, 3~25 parts of Schisandra chinensis, 3~25 parts of Radix Polygalae, 2~12 parts of the seed of Oriental arborvitae.
Preferably, the ratio of weight and number of each raw material is：5~25 parts of wilsonii, 4~20 parts of spina date seed, Schisandra chinensis 4
~20 parts, 4~20 parts of Radix Polygalae, 2~10 parts of the seed of Oriental arborvitae.
Preferably, the ratio of weight and number of each raw material is：8~20 parts of wilsonii, 6~15 parts of spina date seed, Schisandra chinensis 6
~15 parts, 6~15 parts of Radix Polygalae, 3~8 parts of the seed of Oriental arborvitae.
Preferably, the ratio of weight and number of each raw material is：10~15 parts of wilsonii, 8~12 parts of spina date seed, Schisandra chinensis
8~12 parts, 8~12 parts of Radix Polygalae, 4~6 parts of the seed of Oriental arborvitae.
Preferably, the ratio of weight and number of each raw material is：12 parts of wilsonii, 10 parts of spina date seed, 10 parts of Schisandra chinensis, far
10 parts of will, 5 parts of the seed of Oriental arborvitae.
Preferably, the ratio of weight and number of each raw material is：20 parts of wilsonii, 15 parts of spina date seed, 15 parts of Schisandra chinensis, far
15 parts of will, 10 parts of the seed of Oriental arborvitae.
Described pharmaceutical composition can be by said medicine for raw material composition it is any in the form of, as above-mentioned Chinese medicine mixing after pass through
Crush obtained composition or the mixing of above-mentioned Chinese medicine/routinely extracting method is extracted respectively extract or extract into
One step passes through the active component that polishing purification technique obtains, and can also be the extract/active component further according to routine
The conventional oral dosage formulations that preparation process is prepared；
Wherein, the general extraction methods are carried including Soakage extraction, decoction extraction, refluxing extraction, seepage pressure effects, ultrasound
It takes, steam distillation etc.；Extraction solvent includes water, 20~95% ethanol solutions；The polishing purification technique include water extract-alcohol precipitation,
Extraction, silica gel chromatograph post separation, macroreticular resin post separation etc.；The conventional oral dosage formulations include powder, tablet, capsule,
Granula, oral liquid, pill etc..
Pharmaceutical composition of the present invention is in addition to using wilsonii, spina date seed, Schisandra chinensis, Radix Polygalae, the seed of Oriental arborvitae as in the form of raw material
It feeds intake outer, can also be fed intake in the form of the extract (active component) of each bulk pharmaceutical chemicals, therefore the present invention further discloses
A kind of pharmaceutical composition with tranquilizing effect：
A kind of pharmaceutical composition with tranquilizing effect, the ratio of weight and number of each raw material of the pharmaceutical composition are：Thorn
4~30 parts of slender acanthopanax extract, 3~25 parts of Wild jujube seeds extract, 3~25 parts of Schisandra chinens P.E, 3~25 parts of milkwort extract,
2~12 parts of Semen Platycladi extract.
Preferably, the ratio of weight and number of each raw material is：5~25 parts of siberian Ginseng P.E, Wild jujube seeds extract 4~
20 parts, 4~20 parts of Schisandra chinens P.E, 4~20 parts of milkwort extract, 2~10 parts of Semen Platycladi extract.
Preferably, the ratio of weight and number of each raw material is：8~20 parts of siberian Ginseng P.E, Wild jujube seeds extract 6~
15 parts, 6~15 parts of Schisandra chinens P.E, 6~15 parts of milkwort extract, 3~8 parts of Semen Platycladi extract.
Preferably, the ratio of weight and number of each raw material is：10~15 parts of siberian Ginseng P.E, Wild jujube seeds extract 8
~12 parts, 8~12 parts of Schisandra chinens P.E, 8~12 parts of milkwort extract, 4~6 parts of Semen Platycladi extract.
Preferably, the ratio of weight and number of each raw material is：12 parts of siberian Ginseng P.E, 10 parts of Wild jujube seeds extract,
10 parts of Schisandra chinens P.E, 10 parts of milkwort extract, 5 parts of Semen Platycladi extract.
Above-mentioned each extract is respectively the water extract or extractive with organic solvent of each bulk pharmaceutical chemicals；Preferably, it is described organic molten
Agent includes ethyl alcohol, methanol, n-butanol, petroleum ether, ethyl acetate etc..
Invention further provides the preparation methods of aforementioned pharmaceutical compositions, and this method comprises the following steps：
Step a weighs wilsonii, spina date seed, Schisandra chinensis, Radix Polygalae and the seed of Oriental arborvitae by weight；
Step b is prepared into pharmaceutical composition according to customary preparation methods.
Wilsonii of the present invention is drying, root and rhizome or the stem of Araliaceae wilsonii, and pungent, slight bitter, temperature are returned
Spleen, kidney, the heart channel of Hang-Shaoyin have and replenish qi to invigorate the spleen, the effect tonified the kidney to relieve mental strain.Spina date seed this product is the drying and ripening kind of rhamnaceae plant wild jujube
Son, sweet, sour, flat, Return liver, courage, the heart channel of Hang-Shaoyin, the effect that tonifying liver calming heart, arrest sweating promote the production of body fluid.Schisandra chinensis is magnoliaceae schisandra or China
The dry mature fruit of middle Schisandra chinensis, sour, sweet, warm, return lung, the heart, kidney channel have convergence astringent method, nourishing generate fluid, kidney calming
Effect.Radix Polygalae is milk wort Radix Polygalae or the dry root of ovum leaf Radix Polygalae, and bitter, pungent, warm, the thoughts of returning home, kidney, lung channel have benefit of calming the nerves
The effect of intelligence, eliminating phlegm and diminishing swelling.The seed of Oriental arborvitae is the dry mature kernal of cupressaceae plant arbor-vitae, and sweet, flat, the thoughts of returning home, kidney, large intestine channel have
There are mental-tranquilization, hidroschesis ease constipation.
Wilsonii is pungent in side, slight bitter, temperature, replenishes qi to invigorate the spleen, tonifies the kidney to relieve mental strain, reuses as monarch drug in a prescription.Spina date seed is sweet, sour, flat, tonifying liver
Calming heart, Schisandra chinensis nourishing generate fluid, kidney calming are altogether ministerial drug.Radix Polygalae tranquilize the mind and promote the intelligence, seed of Oriental arborvitae mental-tranquilization make altogether for assistant.
For above-mentioned dosage form is enable to realize, pharmaceutically acceptable auxiliary material need to be added in when preparing these dosage forms, such as：Filling
Agent, disintegrant, lubricant, suspending agent, adhesive, sweetener, corrigent, preservative etc., filler includes：Starch, pregelatinated
Starch, lactose, mannitol, chitin, microcrystalline cellulose, sucrose etc., disintegrant includes：Starch, pregelatinized starch, microcrystalline cellulose
Element, sodium carboxymethyl starch, crosslinked polyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, croscarmellose sodium etc., lubrication
Agent includes：Magnesium stearate, lauryl sodium sulfate, talcum powder, silica etc., suspending agent includes：It is polyvinylpyrrolidone, micro-
Crystalline cellulose, sucrose, agar, hydroxypropyl methyl cellulose etc., adhesive includes, starch slurry, polyvinylpyrrolidone, hydroxypropyl
Methylcellulose etc., sweetener includes：Saccharin sodium, aspartame, sucrose, honey element, enoxolone etc., corrigent includes：Sweet tea
Taste agent and various essence, preservative include：Parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, vinegar
Sour chloroethene is fixed, eucalyptus oil etc..
The present invention also provides application of the described pharmaceutical composition in the drug with tranquilizing effect is prepared.
The beneficial effects of the invention are as follows：Pharmaceutical composition of the present invention has effects that tranquilizing and allaying excitement, has to insomniac
Preferable preventive and therapeutic action.Pharmaceutical composition of the present invention composition is simple, novel formula, have it is of low cost, significant in efficacy,
The advantages that having no toxic side effect, and it is applicable to industrialized production.
Specific embodiment
Technical scheme of the present invention is described in further detail, but protection scope of the present invention is not with reference to specific embodiment
It is confined to as described below.
Embodiment 1
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 6g, spina date seed
5g, Schisandra chinensis 5g, Radix Polygalae 5g, seed of Oriental arborvitae 3g.
Embodiment 2
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 120g, spina date seed
100g, Schisandra chinensis 100g, Radix Polygalae 100g, seed of Oriental arborvitae 80g.
Embodiment 3
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 10g, spina date seed
8g, Schisandra chinensis 8g, Radix Polygalae 8g, seed of Oriental arborvitae 5g.
Embodiment 4
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 100g, spina date seed
80g, Schisandra chinensis 80g, Radix Polygalae 80g, seed of Oriental arborvitae 70g.
Embodiment 5
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 20g, spina date seed
15g, Schisandra chinensis 15g, Radix Polygalae 15g, seed of Oriental arborvitae 10g.
Embodiment 6
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 80g, spina date seed
60g, Schisandra chinensis 60g, Radix Polygalae 60g, seed of Oriental arborvitae 50g.
Embodiment 7
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 30g, spina date seed
20g, Schisandra chinensis 20g, Radix Polygalae 20g, seed of Oriental arborvitae 15g.
Embodiment 8
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 60g, spina date seed
50g, Schisandra chinensis 50g, Radix Polygalae 50g, seed of Oriental arborvitae 40g.
Embodiment 9
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 12g, spina date seed
10g, Schisandra chinensis 10g, Radix Polygalae 10g, seed of Oriental arborvitae 5g.
Embodiment 10
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 20g, spina date seed
15g, Schisandra chinensis 15g, Radix Polygalae 15g, seed of Oriental arborvitae 10g.
Embodiment 11
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Siberian Ginseng P.E 6g, acid
Jujube kernel extract 5g, Schisandra chinens P.E 5g, milkwort extract 5g, Semen Platycladi extract 3g.
Embodiment 12
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Siberian Ginseng P.E 120g,
Wild jujube seeds extract 100g, Schisandra chinens P.E 100g, milkwort extract 100g, Semen Platycladi extract 80g.
Embodiment 13
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii water extract
10g, spina date seed water extract 8g, Schisandra chinensis 8g, Radix Polygalae water extract 8g, seed of Oriental arborvitae water extract 5g.
Embodiment 14
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii water extract
100g, spina date seed water extract 80g, Schisandra chinensis water extract 80g, Radix Polygalae water extract 80g, seed of Oriental arborvitae water extract 70g.
Embodiment 15
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii water extract
20g, spina date seed water extract 15g, Schisandra chinensis water extract 15g, Radix Polygalae water extract 15g, seed of Oriental arborvitae water extract 10g.
Embodiment 16
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii ethanol extract
80g, spina date seed ethanol extract 60g, schisandra chinensis ethyl hydrate extract 60g, Radix Polygalae ethanol extract 60g, the extraction of seed of Oriental arborvitae ethyl alcohol
Object 50g.
Embodiment 17
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii ethanol extract
30g, spina date seed ethanol extract 20g, schisandra chinensis ethyl hydrate extract 20g, Radix Polygalae ethanol extract 20g, the extraction of seed of Oriental arborvitae ethyl alcohol
Object 15g.
Embodiment 18
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii methanolic extract
60g, spina date seed methanolic extract 50g, Schisandra chinensis methanolic extract 50g, Radix Polygalae methanolic extract 50g, the extraction of seed of Oriental arborvitae methanol
Object 40g.
Embodiment 19
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii methanolic extract
12g, spina date seed methanolic extract 10g, Schisandra chinensis methanolic extract 10g, Radix Polygalae methanolic extract 10g, the extraction of seed of Oriental arborvitae methanol
Object 5g.
Embodiment 20
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii n-butanol extracts
Object 20g, spina date seed n-butanol extract 15g, Schisandra chinensis n-butanol extract 15g, Radix Polygalae n-butanol extract 15g, the seed of Oriental arborvitae
N-butanol extract 10g.
Embodiment 21
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii petroleum ether extracts
Object 6g, spina date seed ligroin extraction 5g, Schisandra chinensis ligroin extraction 5g, Radix Polygalae ligroin extraction 5g, seed of Oriental arborvitae oil
Ether extract 3g.
Embodiment 22
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii petroleum ether extracts
Object 120g, spina date seed ligroin extraction 100g, Schisandra chinensis ligroin extraction 100g, Radix Polygalae ligroin extraction 100g, cypress
Sub- benevolence ligroin extraction 80g.
Embodiment 23
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii petroleum ether extracts
Object 10g, spina date seed ligroin extraction 8g, Schisandra chinensis ligroin extraction 8g, Radix Polygalae ligroin extraction 8g, seed of Oriental arborvitae oil
Ether extract 5g.
Embodiment 24
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii petroleum ether extracts
Object 100g, spina date seed ligroin extraction 80g, Schisandra chinensis ligroin extraction 80g, Radix Polygalae ligroin extraction 80g, the seed of Oriental arborvitae
Ligroin extraction 70g.
Embodiment 25
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii ethyl acetate carries
Take object 20g, spina date seed ethyl acetate extract 15g, Schisandra chinensis ethyl acetate extract 15g, Radix Polygalae ethyl acetate extract
15g, seed of Oriental arborvitae ethyl acetate extract 10g.
Embodiment 26
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii ethyl acetate carries
Take object 80g, spina date seed ethyl acetate extract 60g, Schisandra chinensis ethyl acetate extract 60g, Radix Polygalae ethyl acetate extract
60g, seed of Oriental arborvitae ethyl acetate extract 50g.
Embodiment 27
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii ethyl acetate carries
Take object 30g, spina date seed ethyl acetate extract 20g, Schisandra chinensis ethyl acetate extract 20g, Radix Polygalae ethyl acetate extract
20g, seed of Oriental arborvitae ethyl acetate extract 15g.
Embodiment 28
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii ethyl acetate carries
Take object 60g, spina date seed ethyl acetate extract 50g, Schisandra chinensis ethyl acetate extract 50g, Radix Polygalae ethyl acetate extract
50g, seed of Oriental arborvitae ethyl acetate extract 40g.
Embodiment 29
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii ethyl acetate carries
Take object 12g, spina date seed ethyl acetate extract 10g, Schisandra chinensis ethyl acetate extract 10g, Radix Polygalae ethyl acetate extract
10g, seed of Oriental arborvitae ethyl acetate extract 5g.
Embodiment 30
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii ethyl acetate carries
Take object 20g, spina date seed ethyl acetate extract 15g, Schisandra chinensis ethyl acetate extract 15g, Radix Polygalae ethyl acetate extract
15g, seed of Oriental arborvitae ethyl acetate extract 10g.
Embodiment 31
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 6g, spina date seed
5g, Schisandra chinensis 5g, Radix Polygalae 5g, seed of Oriental arborvitae 3g are conventionally prepared into powder.
Embodiment 32
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 120g, spina date seed
100g, Schisandra chinensis 100g, Radix Polygalae 100g, seed of Oriental arborvitae 80g are conventionally prepared into powder.
Embodiment 33
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 10g, spina date seed
8g, Schisandra chinensis 8g, Radix Polygalae 8g, seed of Oriental arborvitae 5g are conventionally prepared into powder.
Embodiment 34
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 100g, spina date seed
80g, Schisandra chinensis 80g, Radix Polygalae 80g, seed of Oriental arborvitae 70g are conventionally prepared into granule.
Embodiment 35
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 20g, spina date seed
15g, Schisandra chinensis 15g, Radix Polygalae 15g, seed of Oriental arborvitae 10g are conventionally prepared into granule.
Embodiment 36
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 80g, spina date seed
60g, Schisandra chinensis 60g, Radix Polygalae 60g, seed of Oriental arborvitae 50g are conventionally prepared into granule.
Embodiment 37
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 30g, spina date seed
20g, Schisandra chinensis 20g, Radix Polygalae 20g, seed of Oriental arborvitae 15g are conventionally prepared into pulvis.
Embodiment 38
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 60g, spina date seed
50g, Schisandra chinensis 50g, Radix Polygalae 50g, seed of Oriental arborvitae 40g are conventionally prepared into pulvis.
Embodiment 39
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 12g, spina date seed
10g, Schisandra chinensis 10g, Radix Polygalae 10g, seed of Oriental arborvitae 5g are conventionally prepared into effervescent agent.
Embodiment 40
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii 20g, spina date seed
15g, Schisandra chinensis 15g, Radix Polygalae 15g, seed of Oriental arborvitae 10g are conventionally prepared into effervescent agent.
Embodiment 41
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Siberian Ginseng P.E 6g, acid
Jujube kernel extract 5g, Schisandra chinens P.E 5g, milkwort extract 5g, Semen Platycladi extract 3g are conventionally prepared into bubble
Rise agent.
Embodiment 42
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Siberian Ginseng P.E 120g,
Wild jujube seeds extract 100g, Schisandra chinens P.E 100g, milkwort extract 100g, Semen Platycladi extract 80g, conventionally
Prepare piece agent.
Embodiment 43
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii water extract
10g, spina date seed water extract 8g, Schisandra chinensis 8g, Radix Polygalae water extract 8g, seed of Oriental arborvitae water extract 5g conventionally make
Standby piece agent.
Embodiment 44
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii water extract
100g, spina date seed water extract 80g, Schisandra chinensis water extract 80g, Radix Polygalae water extract 80g, seed of Oriental arborvitae water extract 70g are pressed
More solito prepares piece agent.
Embodiment 45
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii water extract
20g, spina date seed water extract 15g, Schisandra chinensis water extract 15g, Radix Polygalae water extract 15g, seed of Oriental arborvitae water extract 10g are pressed
More solito prepares piece agent.
Embodiment 46
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii ethanol extract
80g, spina date seed ethanol extract 60g, schisandra chinensis ethyl hydrate extract 60g, Radix Polygalae ethanol extract 60g, the extraction of seed of Oriental arborvitae ethyl alcohol
Object 50g, conventionally prepares piece agent.
Embodiment 47
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii ethanol extract
30g, spina date seed ethanol extract 20g, schisandra chinensis ethyl hydrate extract 20g, Radix Polygalae ethanol extract 20g, the extraction of seed of Oriental arborvitae ethyl alcohol
Object 15g, conventionally prepares paste making agent.
Embodiment 48
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii methanolic extract
60g, spina date seed methanolic extract 50g, Schisandra chinensis methanolic extract 50g, Radix Polygalae methanolic extract 50g, the extraction of seed of Oriental arborvitae methanol
Object 40g, conventionally prepares paste making agent.
Embodiment 49
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii methanolic extract
12g, spina date seed methanolic extract 10g, Schisandra chinensis methanolic extract 10g, Radix Polygalae methanolic extract 10g, the extraction of seed of Oriental arborvitae methanol
Object 5g, conventionally prepares paste making agent.
Embodiment 50
A kind of pharmaceutical composition of tranquilizing and allaying excitement, it is made of the raw material of following weight ratio：Wilsonii n-butanol extracts
Object 20g, spina date seed n-butanol extract 15g, Schisandra chinensis n-butanol extract 15g, Radix Polygalae n-butanol extract 15g, the seed of Oriental arborvitae
N-butanol extract 10g, conventionally prepares paste making agent.
Combination and compatibility is carried out after can pharmaceutical composition of the present invention being carried out constituents extraction, wherein ethanol extract and water carries
Object is taken to be respectively provided with good therapeutic effect.Pharmaceutical composition of the present invention has sedative-hypnotic effect, while also has anti-inflammatory analgesic
Effect.
Beneficial effects of the present invention are verified below by specific experimental study：
1. the experimental study of drug tranquilizing effect of the present invention
1.1 test material
Healthy adult SD male rat 50,200 ± 20g of weight is selected, animal is weighed before experiment, is numbered, random point
Into 2 groups of blank control group, model group, experimental drug group, 1 group of control drug and control drug, five groups altogether, every group 10.It presses
Wilsonii, spina date seed, Schisandra chinensis, Radix Polygalae and the seed of Oriental arborvitae are weighed according to weight ratio, specially：
Experimental drug：Wilsonii 120g, spina date seed 100g, Schisandra chinensis 100g, Radix Polygalae 100g, seed of Oriental arborvitae 50g；
Control drug 1：Wilsonii 120g, spina date seed 100g, Schisandra chinensis 100g, Radix Polygalae 100g, seed of Oriental arborvitae 50g, Poria cocos
100g；
Control drug 2：Wilsonii 120g, spina date seed 100g, Schisandra chinensis 100g, Radix Polygalae 100g.
1.2 experimental method
The water that weight is measured for 6-8 times is added in after the mixing of each group drug to decoct 1-1.5 hours, is decocted 2 times, is merged decocting liquid,
It concentrates as 2g/ml.Each group is by the isometric gastric infusions of 2ml, 1 time a day, successive administration 7 days.It is built using fenclonine
Vertical animal model, 2 groups of model group, experimental drug group, 1 group of control drug and control drug give disposable celiac injection to chlorine
Phenylalanine (PCAP) 300mg/kg, blank group give the physiological saline of same dosage.The spontaneous work of each group rat during observation medication
Dynamic and brain nuclei of median raphe neurotransmitter variation.60min and 90min after the last administration observes rat spontaneous activity, then breaks end
Rat extracting blood centrifuges, and is rapidly separated out brain stem under ice bath and weighs, and puts in glass homogenizer, adds in 2% solution of trichloroacetic acid
(being cooled to 4e in advance) 500pL, mild to be homogenized, homogenate is carefully transferred in centrifuge tube with suction pipe, uses 200uLNaHZPO4Solution
(0.33mol/L, pH6.0 include 0.5mol/LNa2EDTA it) swings and washes homogenizer, washing lotion is incorporated to centrifuge tube, is mixed evenly, low temperature
High speed centrifugation takes supernatant 50uL sample introductions to measure.
1.3 result
After fenclonine (PCAP) modeling, the activity time of model group rats is brighter than normal rats in 2min
It is aobvious to increase, and the vertical number of forelimb act also significantly increases in 2min；After drug 60min is given respectively, experimental drug group, control
2 groups of rats of 1 group of drug and control drug activity time and forelimb in 2min are lifted vertical number and are significantly reduced than model group；Dividing
Gei Yao not be after 90min, model group rats are still within active state, experimental drug group rat in 2min the activity time and before
Limb is lifted vertical number and is significantly reduced compared with model group, has statistical significance (p<0.05), 1 group of control drug, 2 groups of control drug have
Downward trend, but do not have statistical significance.This experimental results showed that, compared with control drug 1,2, the drug effect of the present composition
Duration is longer, and action intensity is stronger.It the results are shown in Table 1.
1 each group rat of table spontaneous activity variation compare (N=10)
Note：The * p compared with blank control group<0.05, * * p<0.01；The △ p compared with model group<0.05, △ △ p<0.01.
With blank group compared with, 5-HT, DA, NE, E content are remarkably decreased model group in rat cerebral tissue, pass through difference
After the drug therapy of concentration, there is different degrees of restitution, wherein experimental drug group effect becomes apparent, and has statistics
Meaning (p<0.05).It the results are shown in Table 2.
2 each group rat brain nuclei of median raphe neurotransmitter of table variation compare (N=10)
| Group | 5-HT(ug/g) | DA(ug/g) | NE(ug/g) | E(ug/g) |
| Blank group | 0.88±0.12 | 1.31±0.20 | 3.39±0.21 | 6.32±0.22 |
| Model group | 0.24±0.07** | 0.69±0.12* | 2.57±0.22* | 3.63±0.26* |
| Experimental drug | 0.59±0.15**△△ | 1.09±0.12△ | 3.41±0.25△ | 5.23±0.48△ |
| Control drug 1 | 0.48±0.14**△ | 1.03±0.12* | 2.86±0.58 | 4.28±0.35* |
| Control drug 2 | 0.49±0.17**△ | 0.93±0.10* | 2.79±0.43 | 4.69±0.47* |
Note：The * p compared with blank control group<0.05, * * p<0.01；The △ p compared with model group<0.05, △ △ p<0.01.
It is above-mentioned the experimental results showed that, pharmaceutical composition of the present invention have apparent sedative-hypnotic effect.And and control drug
1st, it 2 compares, the duration of efficacy of the present composition is longer, and action intensity is stronger.
In addition, show that pharmaceutical composition paraxylene of the present invention causes mice auricle swelling, egg white by pharmacodynamic study
Rat paw edema is caused to have inhibiting effect, it is anti-inflammatory to show that pharmaceutical composition of the present invention has the function of.
Claims (10)
1. a kind of pharmaceutical composition with tranquilizing effect, which is characterized in that described pharmaceutical composition is by following parts by weight
Bulk pharmaceutical chemicals composition：4~30 parts of wilsonii, 3~25 parts of spina date seed, 3~25 parts of Schisandra chinensis, 3~25 parts of Radix Polygalae, the seed of Oriental arborvitae 2~
12 parts.
2. pharmaceutical composition as described in claim 1, it is characterised in that：The ratio of weight and number of each raw material is：Thorn five
Add 5~25 parts, 4~20 parts of spina date seed, 4~20 parts of Schisandra chinensis, 4~20 parts of Radix Polygalae, 2~10 parts of the seed of Oriental arborvitae.
3. pharmaceutical composition as described in claim 1, it is characterised in that：The ratio of weight and number of each raw material is：Thorn five
Add 8~20 parts, 6~15 parts of spina date seed, 6~15 parts of Schisandra chinensis, 6~15 parts of Radix Polygalae, 3~8 parts of the seed of Oriental arborvitae.
4. pharmaceutical composition as described in claim 1, it is characterised in that：The ratio of weight and number of each raw material is：Thorn five
Add 12 parts, 10 parts of spina date seed, 10 parts of Schisandra chinensis, 10 parts of Radix Polygalae, 5 parts of the seed of Oriental arborvitae.
5. pharmaceutical composition as described in claim 1, it is characterised in that：The ratio of weight and number of each raw material is：Thorn five
Add 20 parts, 15 parts of spina date seed, 15 parts of Schisandra chinensis, 15 parts of Radix Polygalae, 10 parts of the seed of Oriental arborvitae.
6. such as claim 1-5 any one of them pharmaceutical compositions, which is characterized in that described pharmaceutical composition is each bulk pharmaceutical chemicals
Crush the extract for obtained composition or the mixing of each bulk pharmaceutical chemicals/routinely extracting method is extracted respectively or extract warp
It crosses active component that polishing purification technique obtains or the extract/active component is prepared further according to conventional formulation technique
Obtained conventional oral dosage formulations.
7. pharmaceutical composition as claimed in claim 6, which is characterized in that the general extraction methods are selected from Soakage extraction, decoct
Boil any one in extraction, refluxing extraction, seepage pressure effects, ultrasonic extraction；Extraction solvent is selected from water or 20~95% ethyl alcohol are molten
Liquid；The conventional oral dosage formulations include powder, tablet, capsule, granule, oral liquid or pill.
8. a kind of pharmaceutical composition with tranquilizing effect, which is characterized in that described pharmaceutical composition is by following parts by weight
Raw material composition：4~30 parts of siberian Ginseng P.E, 3~25 parts of Wild jujube seeds extract, 3~25 parts of Schisandra chinens P.E, Radix Polygalae carries
Take 3~25 parts of object, 2~12 parts of Semen Platycladi extract.
9. pharmaceutical composition as claimed in claim 8, which is characterized in that the ratio of weight and number of each raw material is：Thorn five
Add 12 parts of extract, 10 parts of Wild jujube seeds extract, 10 parts of Schisandra chinens P.E, 10 parts of milkwort extract, Semen Platycladi extract 5
Part.
10. Claims 1 to 5,8~9 it is any as described in pharmaceutical composition prepare with tranquilizing effect drug in
Application.
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| CN107753630A (en) * | 2017-11-15 | 2018-03-06 | 北京京师脑力科技有限公司 | The pharmaceutical composition and preparation method of a kind for the treatment of of insomnia patients |
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Application publication date: 20180629 |