CN108208815A - Blueberry and the double-colored composite sheet of lutein ester and preparation method thereof - Google Patents
Blueberry and the double-colored composite sheet of lutein ester and preparation method thereof Download PDFInfo
- Publication number
- CN108208815A CN108208815A CN201810118713.6A CN201810118713A CN108208815A CN 108208815 A CN108208815 A CN 108208815A CN 201810118713 A CN201810118713 A CN 201810118713A CN 108208815 A CN108208815 A CN 108208815A
- Authority
- CN
- China
- Prior art keywords
- lutein ester
- blueberry
- double
- composite sheet
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 title claims abstract description 69
- 235000003095 Vaccinium corymbosum Nutrition 0.000 title claims abstract description 50
- 235000017537 Vaccinium myrtillus Nutrition 0.000 title claims abstract description 50
- 235000021014 blueberries Nutrition 0.000 title claims abstract description 50
- 239000002131 composite material Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 244000077233 Vaccinium uliginosum Species 0.000 title description 3
- 240000000851 Vaccinium corymbosum Species 0.000 claims abstract description 47
- 239000000843 powder Substances 0.000 claims abstract description 45
- 150000005846 sugar alcohols Chemical class 0.000 claims abstract description 18
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims abstract description 18
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 17
- JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-beta,beta-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 claims abstract description 16
- JKQXZKUSFCKOGQ-LQFQNGICSA-N Z-zeaxanthin Natural products C([C@H](O)CC=1C)C(C)(C)C=1C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-LQFQNGICSA-N 0.000 claims abstract description 16
- QOPRSMDTRDMBNK-RNUUUQFGSA-N Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCC(O)C1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C QOPRSMDTRDMBNK-RNUUUQFGSA-N 0.000 claims abstract description 16
- JKQXZKUSFCKOGQ-LOFNIBRQSA-N all-trans-Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C JKQXZKUSFCKOGQ-LOFNIBRQSA-N 0.000 claims abstract description 16
- 239000001775 zeaxanthin Substances 0.000 claims abstract description 16
- 235000010930 zeaxanthin Nutrition 0.000 claims abstract description 16
- 229940043269 zeaxanthin Drugs 0.000 claims abstract description 16
- 241000169546 Lycium ruthenicum Species 0.000 claims abstract description 12
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 12
- 239000003765 sweetening agent Substances 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 239000002253 acid Substances 0.000 claims abstract description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 22
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 21
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 14
- 239000003094 microcapsule Substances 0.000 claims description 13
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 11
- 229930003268 Vitamin C Natural products 0.000 claims description 11
- 235000019359 magnesium stearate Nutrition 0.000 claims description 11
- 235000019154 vitamin C Nutrition 0.000 claims description 11
- 239000011718 vitamin C Substances 0.000 claims description 11
- 238000010348 incorporation Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 239000005913 Maltodextrin Substances 0.000 claims description 8
- 229920002774 Maltodextrin Polymers 0.000 claims description 8
- 239000004310 lactic acid Substances 0.000 claims description 8
- 235000014655 lactic acid Nutrition 0.000 claims description 8
- 229940035034 maltodextrin Drugs 0.000 claims description 8
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 6
- 239000000845 maltitol Substances 0.000 claims description 6
- 235000010449 maltitol Nutrition 0.000 claims description 6
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 6
- 229940035436 maltitol Drugs 0.000 claims description 6
- 239000003826 tablet Substances 0.000 claims description 6
- 229930195725 Mannitol Natural products 0.000 claims description 5
- 239000007891 compressed tablet Substances 0.000 claims description 5
- 239000000594 mannitol Substances 0.000 claims description 5
- 235000010355 mannitol Nutrition 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 241000220324 Pyrus Species 0.000 claims description 4
- 235000021017 pears Nutrition 0.000 claims description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 229960001855 mannitol Drugs 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000011975 tartaric acid Substances 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 235000019631 acid taste sensations Nutrition 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 abstract description 4
- 230000003078 antioxidant effect Effects 0.000 abstract description 3
- 235000006708 antioxidants Nutrition 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 3
- 230000036541 health Effects 0.000 abstract description 3
- 230000036039 immunity Effects 0.000 abstract description 3
- 230000001151 other effect Effects 0.000 abstract description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical group OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 13
- 239000000796 flavoring agent Substances 0.000 description 10
- 235000019634 flavors Nutrition 0.000 description 10
- 230000000694 effects Effects 0.000 description 7
- 208000035719 Maculopathy Diseases 0.000 description 6
- -1 carotenoid aliphatic ester Chemical class 0.000 description 6
- 208000002780 macular degeneration Diseases 0.000 description 6
- 239000012071 phase Substances 0.000 description 5
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 4
- 229960004543 anhydrous citric acid Drugs 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 239000000905 isomalt Substances 0.000 description 4
- 235000010439 isomalt Nutrition 0.000 description 4
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 235000012976 tarts Nutrition 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 229960005375 lutein Drugs 0.000 description 2
- 229940057948 magnesium stearate Drugs 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 2
- NCYCYZXNIZJOKI-IOUUIBBYSA-N 11-cis-retinal Chemical compound O=C/C=C(\C)/C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-IOUUIBBYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- NBGXQZRRLOGAJF-UHFFFAOYSA-N Maltulose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)(CO)OCC1O NBGXQZRRLOGAJF-UHFFFAOYSA-N 0.000 description 1
- CYTYCFOTNPOANT-UHFFFAOYSA-N Perchloroethylene Chemical compound ClC(Cl)=C(Cl)Cl CYTYCFOTNPOANT-UHFFFAOYSA-N 0.000 description 1
- 102000004330 Rhodopsin Human genes 0.000 description 1
- 108090000820 Rhodopsin Proteins 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229930014669 anthocyanidin Natural products 0.000 description 1
- 150000001452 anthocyanidin derivatives Chemical class 0.000 description 1
- 235000008758 anthocyanidins Nutrition 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 208000006278 hypochromic anemia Diseases 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000004410 intraocular pressure Effects 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 235000012680 lutein Nutrition 0.000 description 1
- 239000001656 lutein Substances 0.000 description 1
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- 229940099690 malic acid Drugs 0.000 description 1
- JCQLYHFGKNRPGE-HFZVAGMNSA-N maltulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-HFZVAGMNSA-N 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000004855 vascular circulation Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000008210 xanthophylls Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention relates to a kind of blueberries and the double-colored composite sheet of lutein ester and preparation method thereof, belong to health product technology field.The double-colored composite sheet of blueberry and lutein ester of the present invention includes the raw material of following parts by weight:Glycitols sweetener 40 80%, blueberry powder 3 10%, lycium ruthenicum powder 1 5%, lutein ester 3 10%, zeaxanthin 0.6 2%, acid 1 2.5%, essence 0 1%, releasing agent 0.5 8%.The double-colored composite sheet of blueberry and lutein ester of the present invention improves the taste of lutein ester, increases edible desire and interest, have it is excellent it is anti-oxidant, increase immunity and other effects;Invention also provides a kind of simple and practicable preparation methods.
Description
Technical field
The present invention relates to a kind of blueberries and the double-colored composite sheet of lutein ester and preparation method thereof, belong to health products technology neck
Domain.
Background technology
Lutein ester is a kind of important carotenoid aliphatic ester, is reddish brown fine particle.Primary structure is by two
A six-membered carbon ring is connected by the long-chain of the double bond altogether of a son containing ten eight carbon atoms, and at normal temperatures, the leaf of high-purity is yellow
Plain ester (content 60%-95%) in the orange red powder of golden yellow ester, it be soluble in chloroform, dichloromethane, carbon dichloride, etc. chloros
Hydrocarbon dissolves in the volume of normal hexane, acetone, ethyl acetate, ethyl alcohol, and stability is better than lutein, only high temperature, strong acid,
Lutein ester is destroyed under the factors such as iron ion and oxygen larger.
Because of lutein ester immune and other effects, the flower in blueberry that can supplement eyes macular area pigment, protection retina, enhancing
Color glycosides pigment has eyes good health-care effect, and blueberry can also slow down aging, have antitumaous effect etc., and people study them
Temperature be incremented by with day.
Existing lutein ester pressed candy is mostly disk or Special-shaped sheet, and form is more single, can not meet the requirement of customer.
CN201510730199.8 discloses a kind of blueberry lutein ester oral liquid, and extraction process is complicated, and product is carried and taken all
It is inconvenient.CN201710598385.X discloses a kind of blueberry lutein ester pressed candy, and form is more single, interesting poor;
Tablet forming technique is more complicated, needs to pelletize.
Invention content
The purpose of the present invention is to provide a kind of blueberries and the double-colored composite sheet of lutein ester, and which improve the mouths of lutein ester
Taste increases edible desire and interest, have it is excellent it is anti-oxidant, increase immunity and other effects;Present invention simultaneously provides
A kind of simple and practicable preparation method.
The double-colored composite sheet of blueberry and lutein ester of the present invention includes the raw material of following parts by weight:Glycitols sweet tea
Taste agent 40-80%, blueberry powder 3-10%, lycium ruthenicum powder 1-5%, lutein ester 3-10%, zeaxanthin 0.6-2%, acid
1-2.5%, essence 0-1%, releasing agent 0.5-8%.
The glycitols sweetener is D-sorbite, mannitol, maltitol, xylitol, antierythrite or oligomeric different
It is one or more in maltulose alcohol.
The lutein ester is Lutein ester microcapsule powder.The present invention increases leaf using the lutein ester of microencapsulation processing
The stability of flavine ester can avoid its loss in working process, moreover it is possible to further enhance lutein ester trap and
Bioavailability.The preparation method of the Lutein ester microcapsule powder is as follows:
Including preparing oil-phase solution and aqueous phase solution respectively and the step of by the two mixing and emulsifying.Non-aqueous raw material according to
Mass parts are made of following components:Specific method is:Under the conditions of 40~80 DEG C, by lutein ester crystal, oil phase antioxidant,
Oil phase emulsifier and vegetable oil mixing, stirring and dissolving obtain solution I;It is 2. under the conditions of 50~80 DEG C, wall material, water phase is anti-oxidant
Agent, aqueous emulsifier phase and filler are added to the water, and stirring and dissolving obtains solution II;Wherein the dosage of water is non-aqueous raw material gross mass
1~9 times;3. solution I and solution II mixing and emulsifying 0.5~5 hour, gained lotion is by 10~100MPa is high-pressure homogeneous, spraying
It is dried to obtain cold water dispersion type xanthophyll ester micro capsule powder.
The zeaxanthin, energy enhancing development, protection eyesight and epithelial cell, prevention and maculopathy.
AREDS research shows that:Lutein ester:Zeaxanthin=10mg:During 2mg, be one can protect eyes prevent maculopathy
Optimum proportioning.
The acid is one or more in citric acid, malic acid, vitamin C, lactic acid powder or tartaric acid.
The releasing agent is one or both of magnesium stearate or maltodextrin.
The preparation method of the double-colored composite sheet of blueberry and lutein ester, includes the following steps:
(1) it is sieved:After lutein ester, glycitols sweetener, acid are crossed 20-40 mesh screens respectively, weigh spare;It will
Essence crosses 60-100 mesh screens, with 10% glycitols sweetener mixing, obtains premix A;
(2) dispensing:Premix A and blueberry powder, lycium ruthenicum powder, glycitols sweetener, acid, releasing agent are placed in mixing
It is mixed in device, material incorporation time is 30-40min, must be expected 1.;By premix A and lutein ester, glycitols sweetener, tart flavour
Agent, releasing agent, zeaxanthin are placed in mixer and mix, and material incorporation time is 30-40min, must be expected 2.;
(3) tabletting:Using rotary pelleting machine, 2. first materials 1. compressed tablets, then materials suppress a synusia on the tablet
Agent is to get blueberry lutein ester double color plate.
Compared with prior art, the present invention it has the advantages that:
Rich in anthocyanidin in the blueberry powder and lycium ruthenicum powder added in the present invention, free radical, pre- radiation protection, reduction can be neutralized
Oxidative damage, supplement rhodopsin etc., contribute to sight protection, also assist in and maintain vascular circulation health;Lutein ester, which has, to disappear
Except harmful free radicals, absorb blue light and avoid damaging, enhance the effect of immunity of organisms;Sugar alcohol has reduction intraocular pressure, promotes eye
The effect of portion's residue dissolving excretion;Zeaxanthin has enhancing development, protection eyesight and epithelial cell, prevention
And the effect of maculopathy.The present invention selects sugar-free raw material, diabetes patient's also edible.The present invention is by comprehensively utilizing each raw material
Advantage, and make full use of the synergistic effect of each raw material, have developed novel blueberry and the double-colored composite sheet of lutein ester.The present invention
Blueberry and lutein ester are combined into one, merged the nutrition of the two, improves the taste of lutein ester, and a piece of dichromatism, is increased
Edible desire and interest, wide application of the crowd are added.
Specific embodiment
With reference to embodiment, the present invention is further illustrated, but it is not intended to limit the implementation of the present invention.
Embodiment 1
The double-colored composite sheet of blueberry and lutein ester of the present invention, is made of the raw material of following weight percentage:Mountain
Pears sugar alcohol 68%, Lutein ester microcapsule powder 10%, mannitol 5%, blueberry powder 5%, lycium ruthenicum powder 2%, zeaxanthin 2%,
Vitamin C 0.5%, anhydrous citric acid 1.3%, magnesium stearate 2%, maltodextrin 4%, edible blueberry flavor 0.2%.
Vitamin C also acts as oxidation resistant effect while tart flavour is adjusted, so as to avoid the oxidation of lutein ester,
Reduce its loss.
Lutein ester:Zeaxanthin=10mg:During 2mg, be one can protect eyes prevent the best of maculopathy from matching
Than.
The preparation method of the double-colored composite sheet of blueberry and lutein ester, includes the following steps:
(1) it is sieved:Lutein ester microcapsule powder, D-sorbite, mannitol, vitamin C, anhydrous citric acid are crossed 20 respectively
After mesh screen, weigh spare;Edible blueberry flavor is crossed into 60 mesh screens, with 10% D-sorbite mixing, obtains premix A;
(2) dispensing:By 50% premix A and blueberry powder, lycium ruthenicum powder, 50% (D-sorbite, mannitol, dimension life
Plain C, anhydrous citric acid, magnesium stearate, maltodextrin) it is placed in mixer and mixes, material incorporation time is 30min, must be expected 1.;
By 50% premix A and Lutein ester microcapsule powder, zeaxanthin, 50% (D-sorbite, mannitol, vitamin C, anhydrous
Citric acid, magnesium stearate, maltodextrin) it is placed in mixer and mixes, material incorporation time is 30min, must be expected 2.;
(3) tabletting:Using rotary pelleting machine, 2. first materials 1. compressed tablets, then materials suppress a synusia on the tablet
Agent is to get blueberry lutein ester double color plate.
Embodiment 2
The double-colored composite sheet of blueberry and lutein ester of the present invention, is made of the raw material of following weight percentage:Mountain
Pears sugar alcohol 62.5%, Lutein ester microcapsule powder 10%, isomalt 10%, blueberry powder 8%, lycium ruthenicum powder 1%, maize
Matter 2%, vitamin C 1%, magnesium stearate 5%, edible blueberry flavor 0.5%.
Vitamin C also acts as oxidation resistant effect while tart flavour is adjusted, so as to avoid the oxidation of lutein ester,
Reduce its loss.
Lutein ester:Zeaxanthin=10mg:During 2mg, be one can protect eyes prevent the best of maculopathy from matching
Than.
The preparation method of the double-colored composite sheet of blueberry and lutein ester, includes the following steps:
(1) it is sieved:Lutein ester microcapsule powder, D-sorbite, isomalt, vitamin C are crossed into 40 mesh screens respectively
Afterwards, it weighs spare;Edible blueberry flavor is sieved with 100 mesh sieve into net, with 10% D-sorbite mixing, obtains premix A;
(2) dispensing:By 50% premix A and blueberry powder, lycium ruthenicum powder, 50% (D-sorbite, isomalt,
Vitamin C, magnesium stearate) it is placed in mixer and mixes, material incorporation time is 40min, must be expected 1.;By 50% premix A
It is placed in Lutein ester microcapsule powder, zeaxanthin, 50% (D-sorbite, isomalt, vitamin C, magnesium stearate) mixed
It is mixed in clutch, material incorporation time is 40min, must be expected 2.;
(3) tabletting:Using rotary pelleting machine, 2. first materials 1. compressed tablets, then materials suppress a synusia on the tablet
Agent is to get blueberry lutein ester double color plate.
Embodiment 3
The double-colored composite sheet of blueberry and lutein ester of the present invention, is made of the raw material of following weight percentage:Mountain
Pears sugar alcohol 51.5%, Lutein ester microcapsule powder 10%, maltitol 20%, blueberry powder 5%, lycium ruthenicum powder 4%, zeaxanthin
2%th, lactic acid powder 1.5%, magnesium stearate 3%, maltodextrin 2.5%, edible blueberry flavor 0.5%.
The lactic acid powder, by lactic acid 53-57wt%, glidant silica 1-3wt%, calcium lactate 40-45wt% systems
Into tart flavour quick release continues longer sour, and hygroscopicity is low, reduces the deliquescence of pressed candy.
Lutein ester:Zeaxanthin=10mg:During 2mg, be one can protect eyes prevent the best of maculopathy from matching
Than.
The preparation method of the double-colored composite sheet of blueberry and lutein ester, includes the following steps:
(1) it is sieved:After Lutein ester microcapsule powder, D-sorbite, maltitol, lactic acid powder are crossed 30 mesh screens respectively, claim
It takes spare;Edible blueberry flavor is crossed into 80 mesh screens, with 10% D-sorbite mixing, obtains premix A;
(2) dispensing:By 50% premix A and blueberry powder, lycium ruthenicum powder, 50% (D-sorbite, maltitol, lactic acid
Powder, magnesium stearate, maltodextrin) it is placed in mixer and mixes, material incorporation time is 35min, must be expected 1.;By 50% premix
Expect A and Lutein ester microcapsule powder, zeaxanthin, 50% (D-sorbite, maltitol, lactic acid powder, magnesium stearate, maltodextrin)
It is placed in mixer and mixes, material incorporation time is 35min, must be expected 2.;
(3) tabletting:Using rotary pelleting machine, 2. first materials 1. compressed tablets, then materials suppress a synusia on the tablet
Agent is to get blueberry lutein ester double color plate.
Composite sheet double-colored made from embodiment is subjected to coherent detection, the results are shown in Table 1.
The relevant parameter of 1 double-colored composite sheet of table
Claims (6)
1. a kind of blueberry and the double-colored composite sheet of lutein ester, it is characterised in that include the raw material of following weight percentage:Sugar alcohol
Class sweetener 40-80%, blueberry powder 3-10%, lycium ruthenicum powder 1-5%, lutein ester 3-10%, zeaxanthin 0.6-2%, acid
Taste agent 1-2.5%, essence 0-1%, releasing agent 0.5-8%.
2. blueberry according to claim 1 and the double-colored composite sheet of lutein ester, it is characterised in that:Glycitols sweetener is mountain
It is one or more in pears sugar alcohol, mannitol, maltitol, xylitol, antierythrite or iMOS alcohol.
3. blueberry according to claim 1 and the double-colored composite sheet of lutein ester, it is characterised in that:Lutein ester is lutein
Ester micro capsule powder.
4. blueberry according to claim 1 and the double-colored composite sheet of lutein ester, it is characterised in that:Acid for citric acid,
It is one or more in malic acid, vitamin C, lactic acid powder or tartaric acid.
5. blueberry according to claim 1 and the double-colored composite sheet of lutein ester, it is characterised in that:Releasing agent is magnesium stearate
Or one or both of maltodextrin.
6. the preparation method of a kind of any blueberries of claim 1-5 and the double-colored composite sheet of lutein ester, it is characterised in that
Include the following steps:
(1) it is sieved:After lutein ester, glycitols sweetener, acid are crossed 20-40 mesh screens respectively, weigh spare;By essence
60-100 mesh screens are crossed, with 10% glycitols sweetener mixing, obtain premix A;
(2) dispensing:Premix A and blueberry powder, lycium ruthenicum powder, glycitols sweetener, acid, releasing agent are placed in mixer
Mixing, material incorporation time are 30-40min, must be expected 1.;By premix A and lutein ester, glycitols sweetener, acid, take off
Mould agent, zeaxanthin are placed in mixer and mix, and material incorporation time is 30-40min, must be expected 2.;
(3) tabletting:Using rotary pelleting machine, 2. first materials 1. compressed tablets, then materials suppress a synusia agent on the tablet, i.e.,
Obtain blueberry lutein ester double color plate.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810118713.6A CN108208815A (en) | 2018-02-06 | 2018-02-06 | Blueberry and the double-colored composite sheet of lutein ester and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810118713.6A CN108208815A (en) | 2018-02-06 | 2018-02-06 | Blueberry and the double-colored composite sheet of lutein ester and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108208815A true CN108208815A (en) | 2018-06-29 |
Family
ID=62671070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810118713.6A Pending CN108208815A (en) | 2018-02-06 | 2018-02-06 | Blueberry and the double-colored composite sheet of lutein ester and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108208815A (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109090582A (en) * | 2018-07-23 | 2018-12-28 | 广州市范乐医药科技有限公司 | One kind containing blueberry lutein ester eye health care entertaining piece and its preparation process |
CN109123646A (en) * | 2018-09-30 | 2019-01-04 | 广东亿超生物科技有限公司 | A kind of product and method for production containing zeaxanthin, lutein ester |
CN109938146A (en) * | 2019-03-22 | 2019-06-28 | 西安梵帝罗光学科技有限公司 | A kind of blueberry lutein ester pressed candy and preparation method |
CN110179038A (en) * | 2019-07-04 | 2019-08-30 | 江苏汉典生物科技股份有限公司 | A kind of formula and processing technology of lutein ester effervescent tablet |
CN110226751A (en) * | 2019-07-10 | 2019-09-13 | 完美(广东)日用品有限公司 | A kind of composition with eye protection effect |
CN110801516A (en) * | 2019-10-30 | 2020-02-18 | 通化力神保健品有限公司 | Eye nutrient spray liquid and preparation method thereof |
CN110856549A (en) * | 2018-08-23 | 2020-03-03 | 济南昊雨青田医药技术有限公司 | Sugar-free functional food and preparation method thereof |
CN110856550A (en) * | 2018-08-23 | 2020-03-03 | 济南昊雨青田医药技术有限公司 | Sugar-free functional food and preparation method thereof |
CN110897158A (en) * | 2019-12-09 | 2020-03-24 | 山东国和堂制药有限公司 | Edible blueberry lutein ester tablet |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102389108A (en) * | 2011-10-10 | 2012-03-28 | 大连医诺生物有限公司 | Lutein ester microcapsule powder and preparation method thereof |
CN103494134A (en) * | 2013-08-28 | 2014-01-08 | 沈阳农业大学 | Blueberry lozenge for relieving asthenopia and preparation method thereof |
CN103947967A (en) * | 2014-04-21 | 2014-07-30 | 青海睿元药物研究所有限责任公司 | Black red double-color lycium barbarum slice and preparation method thereof |
CN105533316A (en) * | 2014-11-04 | 2016-05-04 | 威海特伦斯生物工程有限公司 | Production method of blueberry chewable tablets for alleviating visual fatigue |
CN105559066A (en) * | 2015-12-28 | 2016-05-11 | 青岛自然珍萃生物科技有限公司 | Chewable tablet containing lutein ester, zeaxanthin, blueberries and Chinese wolfberry fruits and preparation method thereof |
CN106138199A (en) * | 2016-07-29 | 2016-11-23 | 青岛尚医制药有限公司 | A kind of compound prescription that eyes nutrition protection vision is provided and preparation method thereof |
CN106490619A (en) * | 2016-11-17 | 2017-03-15 | 益倍(天津)生物科技有限公司 | A kind of health food that alleviates asthenopia, prevent visual deterioration |
CN106562277A (en) * | 2015-10-12 | 2017-04-19 | 宁夏乐杞生物科技发展有限公司 | Fructus lycii-folium lycii double-layer double-color chewable tablet and preparation method thereof |
CN106690287A (en) * | 2015-11-18 | 2017-05-24 | 珠海宝德润生健康科技有限公司 | Composition with function of alleviating visual fatigue and preparation method of composition |
CN106912668A (en) * | 2017-02-22 | 2017-07-04 | 云南瑞宝生物科技股份有限公司 | A kind of grape seed extract lutein ester pressed candy and preparation method |
CN106922915A (en) * | 2017-03-14 | 2017-07-07 | 东阿生力源阿胶股份有限公司 | A kind of ginseng donkey-hide gelatin pressed candy and preparation method thereof |
CN107397029A (en) * | 2017-07-21 | 2017-11-28 | 丁伟 | A kind of blueberry lutein ester pressed candy |
-
2018
- 2018-02-06 CN CN201810118713.6A patent/CN108208815A/en active Pending
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102389108A (en) * | 2011-10-10 | 2012-03-28 | 大连医诺生物有限公司 | Lutein ester microcapsule powder and preparation method thereof |
CN103494134A (en) * | 2013-08-28 | 2014-01-08 | 沈阳农业大学 | Blueberry lozenge for relieving asthenopia and preparation method thereof |
CN103947967A (en) * | 2014-04-21 | 2014-07-30 | 青海睿元药物研究所有限责任公司 | Black red double-color lycium barbarum slice and preparation method thereof |
CN105533316A (en) * | 2014-11-04 | 2016-05-04 | 威海特伦斯生物工程有限公司 | Production method of blueberry chewable tablets for alleviating visual fatigue |
CN106562277A (en) * | 2015-10-12 | 2017-04-19 | 宁夏乐杞生物科技发展有限公司 | Fructus lycii-folium lycii double-layer double-color chewable tablet and preparation method thereof |
CN106690287A (en) * | 2015-11-18 | 2017-05-24 | 珠海宝德润生健康科技有限公司 | Composition with function of alleviating visual fatigue and preparation method of composition |
CN105559066A (en) * | 2015-12-28 | 2016-05-11 | 青岛自然珍萃生物科技有限公司 | Chewable tablet containing lutein ester, zeaxanthin, blueberries and Chinese wolfberry fruits and preparation method thereof |
CN106138199A (en) * | 2016-07-29 | 2016-11-23 | 青岛尚医制药有限公司 | A kind of compound prescription that eyes nutrition protection vision is provided and preparation method thereof |
CN106490619A (en) * | 2016-11-17 | 2017-03-15 | 益倍(天津)生物科技有限公司 | A kind of health food that alleviates asthenopia, prevent visual deterioration |
CN106912668A (en) * | 2017-02-22 | 2017-07-04 | 云南瑞宝生物科技股份有限公司 | A kind of grape seed extract lutein ester pressed candy and preparation method |
CN106922915A (en) * | 2017-03-14 | 2017-07-07 | 东阿生力源阿胶股份有限公司 | A kind of ginseng donkey-hide gelatin pressed candy and preparation method thereof |
CN107397029A (en) * | 2017-07-21 | 2017-11-28 | 丁伟 | A kind of blueberry lutein ester pressed candy |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109090582A (en) * | 2018-07-23 | 2018-12-28 | 广州市范乐医药科技有限公司 | One kind containing blueberry lutein ester eye health care entertaining piece and its preparation process |
CN110856549A (en) * | 2018-08-23 | 2020-03-03 | 济南昊雨青田医药技术有限公司 | Sugar-free functional food and preparation method thereof |
CN110856550A (en) * | 2018-08-23 | 2020-03-03 | 济南昊雨青田医药技术有限公司 | Sugar-free functional food and preparation method thereof |
CN109123646A (en) * | 2018-09-30 | 2019-01-04 | 广东亿超生物科技有限公司 | A kind of product and method for production containing zeaxanthin, lutein ester |
CN109938146A (en) * | 2019-03-22 | 2019-06-28 | 西安梵帝罗光学科技有限公司 | A kind of blueberry lutein ester pressed candy and preparation method |
CN110179038A (en) * | 2019-07-04 | 2019-08-30 | 江苏汉典生物科技股份有限公司 | A kind of formula and processing technology of lutein ester effervescent tablet |
CN110226751A (en) * | 2019-07-10 | 2019-09-13 | 完美(广东)日用品有限公司 | A kind of composition with eye protection effect |
CN110801516A (en) * | 2019-10-30 | 2020-02-18 | 通化力神保健品有限公司 | Eye nutrient spray liquid and preparation method thereof |
CN110897158A (en) * | 2019-12-09 | 2020-03-24 | 山东国和堂制药有限公司 | Edible blueberry lutein ester tablet |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108208815A (en) | Blueberry and the double-colored composite sheet of lutein ester and preparation method thereof | |
US9622497B2 (en) | Carotenoid oil suspension with high bioavailability and preparation method thereof | |
CN101292736B (en) | Blueberry tablet and preparation method thereof | |
CN101904502B (en) | Compound xanthophyll soft capsule and preparation method | |
EP2407153B1 (en) | Preparation method of carotenoid oil suspensions with low viscosity and high fluidity | |
CN106912668A (en) | A kind of grape seed extract lutein ester pressed candy and preparation method | |
CN103262931B (en) | The hard candy of water-soluble lutein ester, its preparation method and containing water-soluble lutein ester | |
CA3087279A1 (en) | Composition containing cannabidiol/cannabis extract and caffeine, and application of composition | |
CN105795418A (en) | Eyesight-improving spleen-tonifying pearl Poria honey and preparation method thereof | |
DE60223569T2 (en) | ZEACAROTENE PAINTING FOR FOOD OR PHARMACEUTICALS | |
CN104223260A (en) | Solid health beverage containing resveratrol microcapsule and fructo-oligosaccharide | |
CN109123309A (en) | A kind of astaxanthin-containing can alleviate visual fatigue but also the solid beverage for improving eyesight and preparation method thereof | |
CN106666714A (en) | Sugar-free beta-carotene microcapsules and preparation method thereof | |
CN101283806A (en) | Diet replenisher containing natural carotenol and its preparation technique | |
CN106615516A (en) | Candy containing phaffia rhodozyma astaxanthin and preparation method thereof | |
CN104059007A (en) | Method for extracting lutein ester from marigold flowers | |
CN102960604A (en) | Xylitol and xanthophyll solid drink and preparation method | |
CN102258196A (en) | Health-care food with anti-oxidation function | |
CN114287625B (en) | Carotenoid preparation and application thereof | |
CN108260788A (en) | A kind of jam for being effectively improved branched-chain amino acid bitter taste and preparation method thereof | |
JP5550854B2 (en) | Singlet oxygen scavenger | |
CN104886573A (en) | Composition containing lepidium meyenii walp and lucid ganoderma and preparation method of composition | |
CN104432392A (en) | Heart-strengthening and aging-resisting blueberry solid particle beverage and preparation method thereof | |
CN105517575B (en) | The emulsibility preparation of liposoluble substance | |
CN114276285B (en) | Carotenoid preparation, preparation method and application thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180629 |