CN108208411B - Metabolism immunoregulation composite solution for livestock and poultry and preparation method thereof - Google Patents
Metabolism immunoregulation composite solution for livestock and poultry and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a preparation method of a metabolic immunomodulator composite solution for livestock and poultry, which comprises the following raw materials: astragalus root, honeysuckle flower, Chinese angelica root, white atractylodes rhizome, pilose asiabell root, haw, cyanocobalamine, phosphatide, stabilizing agent, preservative and PH regulator. The compound traditional Chinese medicine extract, the cyanocobalamin and the phospholipid are optimally combined, and a proper stabilizer, a proper preservative and a proper pH regulator are selected to prepare the compound solution, so that the prepared compound solution not only can provide energy for the growth of livestock and poultry and promote metabolism, but also can improve the autoimmunity of the livestock and poultry, improve the anti-stress capability, obviously improve the health condition of the livestock and poultry and improve the production performance, and is suitable for popularization and application of large-scale farms.
Description
Technical Field
The invention belongs to the field of feed additives, and particularly relates to a metabolic immunoregulation composite solution for livestock and poultry and a preparation method thereof.
Background
At present, large-scale breeding is in a trend, but various stress layers are generated continuously due to factors such as breeding environment, breeding equipment and management level, mycotoxin directly influences organism metabolism and normal immunity of livestock and poultry, and huge losses are brought to livestock production due to the fact that the livestock and poultry are hindered in growth, the reproductive performance is reduced, epidemic diseases are frequently generated, and the like. The existing veterinary drug and feed drug additive not only brings risks to food safety, but also brings a series of problems of disorder, low immunity and the like to livestock breeding.
The more livestock and poultry diseases are treated, the more difficult livestock and poultry diseases are treated, the serious treatment, the prevention and the control of diseases, particularly the light health care mode, have the defects of increasingly appearing, and the method which is always successful needs to be changed. The prevention and control of livestock and poultry diseases are always transited from treatment to prevention, and finally the health care singing leading role is realized, the main means is the use of 'immunoregulation', the effective purpose can be finally achieved, and particularly, the method plays an irreplaceable core role in the prevention and control of virus diseases.
Disclosure of Invention
The invention aims to solve the technical problems that the existing veterinary drug and feed drug additives bring risks to food safety and the factors bring metabolic disturbance, low immunity and the like to livestock and poultry breeding, and provides a compound solution which can comprehensively promote metabolism, regulate immunity, resist stress, has no residue, can be orally taken and is convenient to use, and does not cause any risk to livestock products.
The invention also provides a preparation method and application of the metabolic immunomodulator composite solution for livestock and poultry.
The technical scheme adopted by the invention is as follows:
a metabolic immunoregulation composite solution for livestock and poultry is composed of the following raw materials in parts by weight: 20-80 parts of compound traditional Chinese medicine extract, 5-30 parts of phospholipid, 0.005-0.02 part of cyanocobalamine, 5-30 parts of stabilizer, 0.1-0.5 part of preservative, 0.2-0.6 part of pH regulator and 20-80 parts of water; the compound traditional Chinese medicine extract specifically refers to extracts of astragalus mongholicus, honeysuckle, angelica sinensis, bighead atractylodes rhizome, codonopsis pilosula and hawthorn, and the astragalus mongholicus, the honeysuckle, the angelica sinensis, the bighead atractylodes rhizome, the codonopsis pilosula and the hawthorn are respectively 10-40 parts by weight of the astragalus mongholicus, 10-25 parts by weight of the honeysuckle, 10-30 parts by weight of the angelica sinensis, 15-30 parts by weight of the bighead atractylodes rhizome, 15-35 parts by weight of the codonopsis pilosula and 20-40 parts by weight of the hawthorn.
Preferably, the preservative is one or more of methylparaben, ethylparaben, propylparaben, potassium sorbate, sodium benzoate, and benzyl alcohol.
Preferably, the stabilizer is one or more of ethanol, polyethylene glycol, propylene glycol, benzyl alcohol and glycerol.
Preferably, the pH regulator is one or more of sodium hydroxide, potassium hydroxide, arginine, ethanolamine, ethylenediamine, and triethanolamine.
Preferably, the composite solution is prepared from the following raw materials in parts by mass: 70 parts of compound traditional Chinese medicine extract, 20 parts of phospholipid, 0.01 part of cyanocobalamine, 25 parts of stabilizer, 0.1 part of preservative, 0.2 part of pH regulator and 30 parts of water; the compound traditional Chinese medicine extract specifically refers to extracts of astragalus membranaceus, honeysuckle, angelica sinensis, bighead atractylodes rhizome, codonopsis pilosula and hawthorn, and the astragalus membranaceus, the honeysuckle, the angelica sinensis, the bighead atractylodes rhizome, the codonopsis pilosula and the hawthorn are respectively 20 parts by mass, 15 parts by mass, 18 parts by mass, 22 parts by mass, 25 parts by mass and 30 parts by mass.
The preparation method of the metabolic immunomodulator composite solution for livestock and poultry is characterized by comprising the following steps:
(1) weighing radix astragali, flos Lonicerae, radix Angelicae sinensis, Atractylodis rhizoma, radix Codonopsis and fructus crataegi, adding water into the above compound Chinese medicinal materials, extracting under reflux, concentrating the extractive solution, filtering, adding ethanol into the filtrate, precipitating, recovering ethanol, and fine filtering to obtain compound Chinese medicinal extract;
preferably, the reflux extraction temperature in the step (1) is 70-80 ℃, the extraction time is 3-4 hours, and the mass ratio of the compound traditional Chinese medicine to the water is 1: 8-12; and (2) adding ethanol into the solution obtained in the step (1), wherein the ethanol concentration is 60%. (ii) a
(2) Adding phospholipid into stabilizer, stirring to dissolve completely, adding cyanocobalamine, stirring to dissolve completely to obtain phospholipid solution;
(3) heating water to 60-70 deg.C, adding antiseptic, stirring and dissolving completely to obtain clear antiseptic solution;
(4) adding the phospholipid stock solution prepared in the step (2) into the compound traditional Chinese medicine extracting solution prepared in the step (1), stirring uniformly, adding a clear solution of a preservative, controlling the pH to be 5.0-6.0 by using a pH regulator, finely filtering by using a 0.22 micron filter element, and filling to obtain the phospholipid stock solution.
The feed additive can provide energy for livestock, promote metabolism, regulate immunity, resist various stresses, and obviously improve metabolic disturbance and low immunity caused by livestock malnutrition, poor management, growth resistance of young livestock and the like; the feed is suitable for prenatal and postnatal health care of female animals and health care of piglets at birth and weaning, prevents the prenatal and postnatal indigestion, shortens the labor course of sows, recovers physical strength after delivery, and has obvious stress effects on piglets for promoting growth, losing stiffness and weaning; can also be used for improving various stress reactions of poultry and viral disease vaccine antibodies such as newcastle disease, bursa of fabricius, influenza and the like, and ensuring the health of organisms; can also be used for the adjuvant treatment of various diseases, and has the effects of quick disease cure and no recurrence.
Through a large number of experiments, the inventor finds that the phospholipid, the cyanocobalamine, the astragalus mongholicus, the honeysuckle, the angelica sinensis, the bighead atractylodes rhizome, the codonopsis pilosula and the hawthorn which are composite traditional Chinese medicine extracts are combined in an optimal proportion to prepare a composite solution, and the composite solution has an obvious synergistic effect, namely an enhancement effect on promoting metabolism and regulating immunity of livestock, so that the composite solution is particularly suitable for preventing and treating livestock diseases.
Advantageous effects
(1) The solution disclosed by the invention can provide energy for livestock, promote metabolism and regulate immunity, and can obviously improve metabolic disturbance and low immunity caused by livestock malnutrition, poor management, growth obstruction of young livestock and the like.
(2) The invention is simultaneously suitable for prenatal and postnatal health care of the female animals and the health care of the weaned piglets, prevents the prenatal and postnatal indigestion, shortens the labor process of the sows, recovers the physical strength after delivery, and has obvious effects of promoting the growth of the piglets, removing the runt and weaning the piglets.
(3) The invention can also be used for improving various stress reactions of poultry and viral disease vaccine antibodies such as newcastle disease, bursa of fabricius, influenza and the like, and ensures the safety of livestock production.
(4) The invention prepares the phospholipid, the vitamins and the compound traditional Chinese medicine extract into the compound solution, has the advantages of green, safety, environmental protection, no residue, no rebound and the like, can be simultaneously applied to oral administration of livestock and poultry and drinking water of large groups, and is convenient for popularization and application of large-scale farms.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, preferred embodiments of the present invention are described in detail below.
Example 1 preparation method of Metabolic immunomodulator Complex solution for livestock and poultry
The metabolic immunomodulator composite solution for the livestock and the poultry comprises the following components in parts by weight:
20g of compound traditional Chinese medicine extracting solution, 5g of phospholipid, 0.005g of cyanocobalamine, 10g of phospholipid, 5g of propylene glycol, 0.1g of methyl p-hydroxybenzoate, 0.2g of sodium hydroxide and 20g of water.
The metabolic immunomodulator composite solution for livestock and poultry is prepared by adopting the following method:
(1) 10g of astragalus, 25g of honeysuckle, 10g of angelica, 30g of bighead atractylodes rhizome, 15g of codonopsis pilosula and 40 g of hawthorn are extracted by a traditional Chinese medicine hot reflux low-temperature extraction low-temperature concentration unit, the extraction temperature is 80 ℃, the water addition amount is 8 times, the extraction time is 3 hours, the extract is concentrated to about 2g of crude drug per milliliter, the extract is centrifugally filtered, ethanol is added to reach the concentration of 60 percent, the ethanol is recovered, a 0.45 micron filter core is selected for fine filtration, and the composite traditional Chinese medicine extract is obtained and refrigerated for later use.
(2) Adding 5g of phospholipid into 5g of propylene glycol, stirring and dissolving uniformly, adding 0.005g of cyanocobalamine, and stirring and dissolving completely for later use.
(3) Heating 20g of water to 70 ℃, adding 0.1g of methyl p-hydroxybenzoate, stirring and dissolving completely, and keeping for later use.
(4) And (3) adding the phospholipid standby liquid completely dissolved in the step (2) into 20g of the compound traditional Chinese medicine extracting solution subjected to fine filtration in the step (1), uniformly stirring, adding the methyl p-hydroxybenzoate solution prepared in the step (3), adjusting the pH to 5.7 by using sodium hydroxide, performing fine filtration by using a 0.22-micron filter core, introducing nitrogen, filling, and sterilizing at 100 ℃ for 20 minutes to obtain the phospholipid standby liquid.
Example 2 preparation method of Metabolic immunomodulator Complex solution for livestock and poultry
The metabolic immunomodulator composite solution for the livestock and the poultry comprises the following components in parts by weight:
80g of compound traditional Chinese medicine extracting solution, 0.02g of cyanocobalamine, 30g of phospholipid, 30g of polyethylene glycol, 0.52g of ethyl p-hydroxybenzoate, 0.6g of sodium hydroxide and 80g of water.
The metabolic immunomodulator composite solution for livestock and poultry is prepared by adopting the following method:
(1) 40 g of astragalus, 10g of honeysuckle, 30g of angelica, 15g of bighead atractylodes rhizome, 35 g of codonopsis pilosula and 20g of hawthorn are extracted by a traditional Chinese medicine hot reflux low-temperature extraction low-temperature concentration unit at the extraction temperature of 78 ℃ and 10 times of water addition amount for 4 hours, the extracting solution is concentrated to ensure that each milliliter contains 2g of crude drug, the centrifugal filtration is carried out, ethanol is added until the concentration is 60 percent, after the ethanol is recovered, a 0.45 micron filter core is selected for fine filtration to obtain a composite traditional Chinese medicine extracting solution, and the composite traditional Chinese medicine extracting solution is refrigerated for later use.
(2) Adding 30g of phospholipid into 30g of polyethylene glycol, stirring and dissolving uniformly, adding 0.02g of cyanocobalamine, stirring and dissolving completely, and keeping for later use.
(3) Heating 80g of water to 60 ℃, adding 0.52g of ethyl p-hydroxybenzoate, stirring and dissolving uniformly and completely, and then keeping for later use.
(4) And (3) adding the completely dissolved phospholipid standby solution prepared in the step (2) into 80g of the compound traditional Chinese medicine extracting solution subjected to fine filtration in the step (1), uniformly stirring, adding the clear ethyl p-hydroxybenzoate solution dissolved in the step (3), adjusting the pH to 5.6 by using a sodium hydroxide solution, selecting a 0.22-micron filter core for fine filtration, introducing nitrogen, filling, and sterilizing at 100 ℃ for 20 minutes to obtain the phospholipid standby solution.
Example 3 preparation method of Metabolic immunomodulator Complex solution for livestock and poultry
The metabolic immunomodulator composite solution for the livestock and the poultry comprises the following components in parts by weight: 70g of compound traditional Chinese medicine extract, 20g of phospholipid, 0.01g of cyanocobalamine, 25g of ethanol, 0.1g of methyl p-hydroxybenzoate, 0.2g of arginine and 30g of water;
is prepared from astragalus root 20 parts, honeysuckle flower 15 parts, Chinese angelica root 18 parts, white atractylodes rhizome 22 parts, pilose asiabell root 25 parts, haw 30 parts.
The metabolic immunomodulator composite solution for livestock and poultry is prepared by adopting the following method:
(1) 20 parts of astragalus membranaceus, 15 parts of honeysuckle, 18 parts of angelica sinensis, 22 parts of bighead atractylodes rhizome, 25 parts of codonopsis pilosula and 30 parts of hawthorn are extracted by a traditional Chinese medicine hot reflux low-temperature extraction low-temperature concentration unit, the extraction temperature is 75 ℃, the water addition amount is 12 times, the extraction time is 4 hours, the extracting solution is concentrated to 2g of crude drug in each milliliter, centrifugal filtration is carried out, ethanol is added until the concentration is 60%, after the ethanol is recovered, a 0.45 micrometer filter core is selected for fine filtration, and a composite traditional Chinese medicine extracting solution is obtained and is refrigerated for later use.
(2) Adding 25g of phospholipid into 15g of ethanol, stirring and dissolving uniformly, adding 0.01g of cyanocobalamine, and stirring and dissolving completely for later use.
(3) Heating 50g of water to 75 ℃, adding 0.3g of methyl p-hydroxybenzoate, stirring and dissolving completely, and keeping for use.
(4) And (3) adding the completely dissolved phospholipid standby solution prepared in the step (2) into 50g of the compound traditional Chinese medicine extracting solution subjected to fine filtration in the step (1), uniformly stirring, adding the methyl p-hydroxybenzoate solution prepared in the step (3), adjusting the pH to 5.5 by using sodium hydroxide, performing fine filtration by using a 0.22-micron filter element, introducing nitrogen, filling, and sterilizing at 100 ℃ for 20 minutes to obtain the finished product.
The clinical test data of the metabolic immunomodulator complex solution for livestock and poultry of the embodiment are as follows:
first, the health care effect of the invention on the sows and piglets
1. Test grouping and protocol: 1200 pregnant sows with the same number of births and the same variety are selected and divided into a test 1 group, a test 2 group, a test 3 group and a control group, wherein each group has 300 pregnant sows, and the pregnant sows respectively correspond to the pregnant sows in the example 1, the example 2 and the example 3 of the invention and do not use any additives.
(1) The test groups are orally taken or injected with 10 ml/head in one week before the birth of the sow, 10 ml/head in the postnatal period of the last piglet and 10 ml/head in one week after the birth. The following indexes are observed statistically: anorexia and indigestion of sow, sow labor, endometritis, vulvar malignant edema, rectocele/rectocele, lochiorrhea, no food or milk intake after delivery, and less or no milk intake after delivery. The observation period ranged from 7 days prenatal to 15 days postpartum.
(2) Piglets born by sows in the test 1 group, the test 2 group and the test 3 group respectively correspond to 0.2ml per oral administration after birth and 0.5ml per oral administration at weaning of the invention in the examples 1, 2 and 3, and the following indexes are observed statistically with a control group: diarrhea rate, cad pig rate, mortality rate. The observation period ranged from the first day post partum to 7 days post weaning.
And counting health care effect data on the sows:
the comprehensive data show that compared with a control group, the probability of health abnormality of sows can be greatly reduced by using the compound of the invention in the embodiments 1, 2 and 3, wherein the group 2 and the group 3 are better than the group 1, and the cost performance of the compound of the invention in the embodiment 2 is highest in consideration of the practical application cost.
And counting the health care effect data on the piglets:
the comprehensive data show that compared with a control group, the diarrhea rate, the cad pig rate and the death rate of piglets can be greatly reduced by using the invention in the examples 1, 2 and 3, wherein the experiment 2 and the experiment 3 are better than the experiment 1, and the cost performance of the invention in the example 2 is highest in consideration of the practical application cost.
Secondly, the clinical treatment effect of the invention on the sows
The data are obtained in 2009-2016 years according to the summary of practical clinical data of the personnel in the company market department, and the dosage is 0.1ml/Kg of body weight.
The comprehensive data show that compared with a control group, the metabolic diseases such as anorexia/indigestion, too long labor course and the like of sows can be effectively treated by using the compounds of the invention in the examples 1, 2 and 3, wherein the test 2 and the test 3 are better than the test 1, and the cost performance of the compound of the invention in the example 2 is highest in consideration of practical application cost.
Influence of the invention on the production performance and immune function of broiler chicken
Materials and methods
Selecting 4 barns with the same batch of young chickens (fast large AA broiler chickens), the same farm, the same management mode and feeding level, and 21220 chickens in the test 1 group, wherein the solution obtained in the embodiment 1 of the invention is used; test 2 group consisting of 21550 individuals, using the solution obtained in inventive example 2; test 3 groups total 20990, using the solution obtained in inventive example 3; each test group is respectively 1-3 days old, 10-12 days old, 19-21 days old and 29-31 days old, and the dosage of each test group is calculated according to the total day at night, and each test group is intensively used according to 5L of water added per ml; the control group was fed with no addition of 21880 s in total, and the period of the test was 40 days after the end of the test until the age of 41 days. And tracking and recording the death and culling rate, the survival rate and the feed conversion ratio in the whole process.
At 14 days and 28 days, 15 animals were randomly selected and killed, and immune organ index was measured. The detection method of immune organ index is that weighing chicken, taking blood from heart, then discharging blood from carotid artery to kill, taking spleen, bursa of fabricius and thymus rapidly, removing fat and weighing fresh weight. Each immune organ index was calculated according to the formula immune organ index = immune organ weight/body weight.
20 blood samples were randomly selected from 1 day old, 7 days old, 14 days old, 21 days old, 28 days old and 35 days old, and blood was collected from the wing vein. The Newcastle disease antibody level is averaged by adopting a hemagglutination experiment and a hemagglutination inhibition experiment; the infectious bursal disease serum antibody detection adopts an ELISA method.
(II) test results
1. The influence of the invention on the production performances of the broiler such as death and culling rate, survival rate, feed conversion ratio and the like
The influence of the invention on the production performances of the broiler such as death and culling rate, survival rate, feed conversion ratio and the like
As can be seen from the table, the test groups 1, 2 and 3 can obviously reduce the death and culling rate, improve the survival rate and reduce the feed conversion ratio. The death and culling rate of the test group is respectively reduced by 2.12 percent, 3.22 percent and 3.17 percent compared with the control group, the survival rate is respectively improved by 2.12 percent, 3.22 percent and 3.17 percent, and the feed-meat ratio is respectively reduced by 0.13 percent, 0.27 percent and 0.28 percent. The test 2 group and the test 3 group are close to each other and better than the test 1 group, and the cost performance of the test is highest in consideration of the practical application cost in the embodiment 2 of the invention.
Influence of the invention on broiler chicken immune organ index
Influence of the invention on broiler immunization organ index
The test results show that compared with the control group, the test groups 1, 2 and 3 can improve thymus index, spleen index and bursal disease index at the ages of 14 days and 28 days, wherein the test group 2 and the test group 3 have equivalent effects and are slightly better than the test group 1.
The Effect of the inventive Agents on the level of antibodies to Newcastle disease
Effect of the inventive Agents on Newcastle disease antibody levels (Log 2 antibody Titers)
The test results show that compared with a control group, the test 1 group, the test 2 group and the test 3 group of the invention obviously improve the newcastle disease antibody level of broiler chickens of 14 days old and 28 days old, and extremely obviously improve the newcastle disease antibody level of 21 days old and 35 days old.
Effect of the inventive Agents on the level of infectious bursal disease antibodies
Effect of the inventive Agents on infectious bursal disease antibody levels
Test results show that compared with a control group, the test 1 group, the test 2 group and the test 3 group of the invention can remarkably improve the level of infectious bursal disease antibodies of broilers of 21-day-old, 28-day-old and 35-day-old.
Stability test of metabolic immunomodulator composite solution for livestock and poultry
The stability of the product is a basic condition for ensuring safe and effective use, and particularly, the content of the vitamin product is reduced rapidly under the conditions of high temperature and high humidity and water, so the stability test is an important problem of the research of the subject. Since the invention is a composite solution and cyanocobalamin belongs to vitamins and is sensitive to strong light, the storage condition is set to be light-shielding and sealed. The product was tested for high temperature and high humidity acceleration (temperature 40) using cyanocobalamin as the main component and the solutions prepared in examples 1, 2 and 3 as stability test samples numbered 01, 02 and 03, respectively+2 ℃, relative humidity 75% for 6 months) and room temperature long term sample retention investigation tests (temperature 25 ℃)+At 2 ℃, 60% relative humidity for 15 months). The results are as follows:
A. high temperature and high humidity test results
B. Long term room temperature sample retention test results
And (4) test conclusion: the metabolic immunomodulator composite solution for livestock and poultry produced by the method is packaged by using a commercial product, and a normal temperature test and an accelerated test are carried out according to the pharmacopeia standard strictly, and from the observation result, the property, the pH value and the content of cyanocobalamine in the formula are all in the specified range, which shows that the composite solution prepared by the method has good stability.
Claims (7)
1. The metabolic immunoregulation composite solution for livestock and poultry is characterized by comprising the following raw materials in parts by mass: 20-80 parts of compound traditional Chinese medicine extract, 5-30 parts of phospholipid, 0.005-0.02 part of cyanocobalamine, 5-30 parts of stabilizer, 0.1-0.5 part of preservative, 0.2-0.6 part of pH regulator and 20-80 parts of water; the compound traditional Chinese medicine extract specifically refers to extracts of astragalus membranaceus, honeysuckle, angelica sinensis, bighead atractylodes rhizome, codonopsis pilosula and hawthorn, the astragalus membranaceus, the honeysuckle, the angelica sinensis, the bighead atractylodes rhizome, the codonopsis pilosula and the hawthorn are respectively 10-40 parts by weight of the astragalus membranaceus, 10-25 parts by weight of the honeysuckle, 10-30 parts by weight of the angelica sinensis, 15-30 parts by weight of the bighead atractylodes rhizome, 15-35 parts by weight of the codonopsis pilosula and 20-40 parts by weight of the hawthorn, and the compound solution can be used for preparing a compound with a health-care effect on sows;
the preparation method of the metabolic immunomodulator composite solution for livestock and poultry adopts the following steps:
(1) weighing radix astragali, flos Lonicerae, radix Angelicae sinensis, Atractylodis rhizoma, radix Codonopsis and fructus crataegi, adding water into the above compound Chinese medicinal materials, extracting under reflux, concentrating the extractive solution, filtering, adding ethanol into the filtrate, precipitating, recovering ethanol, and fine filtering to obtain compound Chinese medicinal extract;
(2) adding phospholipid into stabilizer, stirring to dissolve completely, adding cyanocobalamine, stirring to dissolve completely to obtain phospholipid solution; heating water to 60-70 deg.C, adding antiseptic, stirring and dissolving completely to obtain clear antiseptic solution;
(3) adding the phospholipid stock solution prepared in the step (2) into the compound traditional Chinese medicine extract in the step (1), stirring uniformly, adding a clear solution of a preservative, controlling the pH to be 5.0-6.0 by using a pH regulator, finely filtering by using a 0.22 micron filter element, and filling to obtain the phospholipid stock solution.
2. The metabolic immunoregulation composite solution for livestock and poultry according to claim 1, wherein the preservative is one or more of methylparaben, ethylparaben, propylparaben, potassium sorbate, sodium benzoate, and benzyl alcohol.
3. The metabolic immunoregulation composite solution for livestock and poultry according to claim 1, wherein the stabilizer is one or more of ethanol, polyethylene glycol, propylene glycol, benzyl alcohol and glycerol.
4. The metabolic immunoregulation composite solution for livestock and poultry according to claim 1, wherein the pH regulator is one or more of sodium hydroxide, potassium hydroxide, arginine, ethanolamine, ethylenediamine and triethanolamine.
5. The metabolic immunoregulation composite solution for livestock and poultry according to any one of claims 1-4, characterized in that the composite solution is composed of the following raw materials in parts by mass: 70 parts of compound traditional Chinese medicine extract, 20 parts of phospholipid, 0.01 part of cyanocobalamine, 25 parts of stabilizer, 0.1 part of preservative, 0.2 part of pH regulator and 30 parts of water; the compound traditional Chinese medicine extract specifically refers to extracts of astragalus membranaceus, honeysuckle, angelica sinensis, bighead atractylodes rhizome, codonopsis pilosula and hawthorn, and the astragalus membranaceus, the honeysuckle, the angelica sinensis, the bighead atractylodes rhizome, the codonopsis pilosula and the hawthorn are respectively 20 parts by mass, 15 parts by mass, 18 parts by mass, 22 parts by mass, 25 parts by mass and 30 parts by mass.
6. The metabolic immunoregulation composite solution for livestock and poultry according to claim 1, wherein the reflux extraction temperature in the step (1) is 70-80 ℃, the extraction time is 3-4 hours, and the mass ratio of the composite traditional Chinese medicine to water is 1: 8-12.
7. The metabolic immunoregulation composite solution for livestock and poultry according to claim 1, wherein the ethanol concentration in the solution after ethanol addition in step (1) is 60%.
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