CN108186879A - A kind of alleviation physical fatigue Chinese medicine health-care composition and preparation method - Google Patents
A kind of alleviation physical fatigue Chinese medicine health-care composition and preparation method Download PDFInfo
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Abstract
A kind of alleviation physical fatigue Chinese medicine health-care composition of the present invention and preparation method, belong to field of health care food.The Chinese medicine health-care composition includes the component of following weight：80 150 parts of American Ginseng, 30 60 parts of cervus elaphus linnaeus, 30 70 parts of Semen Cuscutae extract, 30 70 parts of ophiopogon japonicus extract, 01 parts of function and service agent；The function and service agent is one or both of benefiting qi and nourishing blood agent, Anshen Bunao agent, strengthening spleen and nourishing stomach agent；The health composition further includes the auxiliary material that parts by weight are 0.2 1 parts, and the auxiliary material includes the component of following parts by weight：30 60 parts of dextrin, 13 parts of sodium carboxymethylcellulose, 24 parts of magnesium stearate.A kind of preparation method for alleviating physical fatigue Chinese medicine health-care composition, including：Pulverize and sieve, mixing granulation, tabletting encapsulation to get.The health composition can effectively fatigue-relieving and enhancing resistance to oxidation, take and easy to carry, be suitble to the needs of present fast pace life.
Description
Technical field
A kind of alleviation physical fatigue Chinese medicine health-care composition of the present invention and preparation method, belong to field of health care food.
Background technology
Since present social competition is growing more intense, work strain, the reasons such as interpersonal relationships is complicated, and psychological pressure is big, Asia is good for
Health, the crowd of physical fatigue are more and more.It is often in the mankind of this state and can generate insomnia, dreaminess, be not easy to fall asleep or is white
Phenomena such as it is dozed off；Chronic fatigue syndrome can be formed after time is longer, is a kind of protection machine of our physiologicals of itself
System is the signal of a kind of pathological state and our rests, if no matter ignoring will make one to generate feeling of fatigue, body meeting
It is damaged, falls sick from overwork, influence our quality of life.And because long-term work and rest is not normal, being busy with one's work leads to eating and drinking without temperance,
Feelings will is unsuccessful, stagnation of liver qi, causes the dysfunction of the spleen in transport, and gastral cavilty is become estranged, with the passing of time middle gas virtual loss, so as to cause various incoordination between the spleen and the stomach diseases
Shape.
Theory of traditional Chinese medical science thinks the appearance of fatigue phenomenon, related with the five internal organs, the overwork loss that can cause human body vital essence, gas
Anemia is empty, makes one external disfigurement body, interior viscerotrauma；Liver governing tendons, spleen governing limbs muscle, fatigue can the internal organs such as impairment of the spleen liver stomach, occur
Limb muscle ache, joint stuffiness；Excessive thinking and anxiety can injure the heart, spleen, liver, easily cause the deficiency of blood or conscience two empty, it is seen that dizzy, strong
The diseases such as forget, be indigestion and loss of appetite, becoming thin；Body fatigue and the further development of mind fatigue, can make visceral dysfunction or decline, form the deficiency of Yin
The high extremely caused excess fire of gas of the fire of deficiency type caused by laboured breathing or positive sum, then injures lung, kidney internal organs is allowed to pathological symptom occur.Between the five internal organs
There is substantial connection, they influence each other, interact, common to participate in body operating.Qi-restoratives righting is clinically mainly used, Eradicates is tired
Prescription prevention, treatment, the control of tranquilizing the mind reach fatigue-relieving symptom.
It is had been reported that in another this composition drug and reduces radical damage, antioxidation, there is the effect of delaying to decline cell ageing；
According to the free radical of aging -- oxidative stress is theoretical and traditional Chinese medical science aging is theoretical, and the common kidney and spleen invigorating of clinic, blood-enrich prevention decline
Always, also from the harm and prevention of side illustration fatigue.
Therefore developing a kind of alleviation physical fatigue Chinese medicine health-care composition has broad sense, while is exploitation integration of drinking and medicinal herbs
Chinese medicine shares offer reference frame.
Invention content
Overcome the deficiencies in the prior art of the present invention, the technical problem to be solved is that provide a kind of alleviation physical fatigue Chinese medicine
Health composition and preparation method, the health composition can effectively fatigue-relieving and enhancing resistance to oxidation, take with it is easy to carry,
It is suitble to the needs of present fast pace life.
A kind of alleviation physical fatigue Chinese medicine health-care composition of the present invention includes the component of following weight：American Ginseng
80-150 parts, 30-60 parts of cervus elaphus linnaeus, 30-70 parts of Semen Cuscutae extract, 30-70 parts of ophiopogon japonicus extract, 0-1 parts of function and service agent,
1 part of auxiliary material；
The function and service agent is one or both of benefiting qi and nourishing blood agent, Anshen Bunao agent, strengthening spleen and nourishing stomach agent；
The benefiting qi and nourishing blood agent includes the component of following weight：20-30 parts of Radix Astragali, 6-9 parts of Radix Angelicae Sinensis, jujube 10-
20 parts, 10-20 parts of matrimony vine；
The Anshen Bunao agent includes the component of following weight：30-40 parts of spina date seed, 20-30 parts of Radix Angelicae Sinensis, lotus seeds
10-15 parts, 20-30 parts of sealwort；
The strengthening spleen and nourishing stomach agent includes the component of following weight：10-15 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of Poria cocos, Radix Glycyrrhizae 7-
9 parts.
The ophiopogon japonicus extract refers to the water extract of Radix Ophiopogonis, and total starches content is no less than 60%；The Semen Cuscutae extract
Refer to the alcohol extract of Semen Cuscutae, general flavone content is no less than 60%.
The auxiliary material includes the component of following parts by weight：30-60 parts of dextrin, 1-3 parts of sodium carboxymethylcellulose, magnesium stearate
2-4 parts.
The auxiliary material can also be made of the component of following parts by weight：27 parts of Icing Sugar, 8 parts of PVP K30, magnesium stearate
2-4 parts, appropriate amount of ethanol.
The raw material adds in auxiliary material through tablet, capsule, aqua or paste made from corresponding technique.
A kind of preparation method for alleviating physical fatigue Chinese medicine health-care composition, includes the following steps：
It weighs：Each raw material are weighed according to the weight；
It pulverizes and sieves：Semen Cuscutae extract is taken to be uniformly mixed with ophiopogon japonicus extract, obtains mixture A；By each traditional Chinese medicinal components point
It does not crush, sieves with 100 mesh sieve, obtain traditional Chinese medicinal components fine powder, mixture A with traditional Chinese medicinal components fine powder is uniformly mixed, obtains mixture B；
Mixing granulation：30 parts of dextrin, mixing are added in into mixed powder B, with 3% carboxymethylcellulose sodium solution softwood,
20 mesh screens are pelletized, and are dried below 60 DEG C of wet granular, and the control of powder moisture sieves whole grain in 4.0%~6.0%, 18 mesh；
Tabletting encapsulates：It adds in magnesium stearate to be uniformly mixed, tabletting, then is coated, packed with stomach dissolved film coating pre-mix dose,
To obtain the final product.
3% carboxymethylcellulose sodium solution refers to the sodium carboxymethylcellulose ethanol solution that mass fraction is 3%.
American Ginseng, nature and flavor and channel tropism：Sweet, slight bitter, it is cool.The thoughts of returning home, lung, kidney channel.Function is with curing mainly：Boosting qi and nourishing yin, heat-clearing life
Tianjin.For deficiency of vital energy yin deficiency, abnormal heat is tired of tired, cough and asthma phlegm blood, Heat Diabetes, dryness of the mouth and throat.
Cervus elaphus linnaeus, nature and flavor and channel tropism：It is sweet, salty, temperature.Return kidney, Liver Channel.Function is with curing mainly：Invigorating kidney yang, benefiting essence-blood, strengthening the bones and muscles,
Punching is adjusted to appoint, torr sore poison.For the insufficiency of the kidney yang, blood and essence asthenia, impotence involuntary emission, uterus cold infertile is thin thin, refreshing tired, chilly, dizziness, ear
Ring, deaf, spinal column crymodynia, muscles and bones impotence, under uterine bleeding band, cloudy subcutaneous ulcer is not held back.
Semen Cuscutae extract, nature and flavor and channel tropism：Pungent, sweet and neutral.Return liver, kidney, the spleen channel.Function is with curing mainly:It tonifies the liver and kidney, Gu
Final minification is urinated, tocolysis, improving eyesight, antidiarrheal；External application disappears wind nti-freckle.For kidney deficiency and liver, soreness and weakness of waist and knees, impotence and seminal emission, enuresis frequent micturition, kidney
Empty threatened abortion, fetal irritability, blurred vision tinnitus, spleen kidney deficiency are rushed down.
Ophiopogon japonicus extract, nature and flavor and channel tropism:Sweet, slight bitter, is slightly cold.The thoughts of returning home, lung, stomach.Function is with curing mainly：Nourishing Yin and promoting production of body fluid,
Moistening lung clears away heart-fire.For dryness of the lung dry cough, cough for deficiency of Yin consumptive disease, larynx numbness pharyngalgia, injury thirst, Heat Diabetes, vexed insomnia, dry constipation of intestines.
The present invention has the beneficial effect that compared to the prior art：
(1) we based on TCM theory, by diagnosis and treatment based on an overall analysis of the illness and the patient's condition, Yin Yang balancing, using medicine eaten by recuperating qi-blood, internal organs
Homologous traditional Chinese medical theory combination modern scientific research carries out compatibility, is extracted with American Ginseng, cervus elaphus linnaeus, Semen Cuscutae extract, Radix Ophiopogonis
" reinvigoration " that object is advocated with the traditional Chinese medical science, " treatinging deficiency with tonification " are this, it is qi-blood tonifying, strengthen the body resistance to consolidate the constitution, beneficial blood yin-nourishing, the five internal organs that reconcile,
Reach and restore the normal function of body with fatigue-relieving.
(2) present invention can be directed to different crowd need, be made have effects that benefiting qi and nourishing blood, Anshen Bunao, strengthening spleen and nourishing stomach,
Physical fatigue, strengthen immunity, oxidation resistant Chinese medicine health-care composition can be alleviated.
(3) coated tablet, capsule is made using Modern preparations technology simultaneously in the present invention, and pharmacological property is stable, safe and effective, side
Housecoat is used, is carried, and suitable for big production, adapts to wider consumer groups.Sodium carboxymethylcellulose increases bond strength,
It can improve the compressibility of tablet, improve hardness finish, while drying time is short, volatile removing ethyl alcohol.Magnesium stearate is total
When mass fraction is 1% or so in drug composition, press the tabletting sticking of plain piece, smooth appearance, hardness, friability, disintegration time limited,
Angle of repose etc. optimal quality.
Specific embodiment
With reference to specific embodiment, the present invention is described in further detail, but protection scope of the present invention is not
Be limited to these embodiments, it is every without departing substantially from the change of present inventive concept or equivalent substitute be included in protection scope of the present invention it
It is interior.
Embodiment 1
A kind of alleviation physical fatigue Chinese medicine health-care composition of the present invention includes the component of following weight：American Ginseng
80-150 parts, 30-60 parts of cervus elaphus linnaeus, 30-70 parts of Semen Cuscutae extract, 30-70 parts of ophiopogon japonicus extract, 0.2-1 parts of auxiliary material；
The ophiopogon japonicus extract refers to the water extract of Radix Ophiopogonis, and total starches content is no less than 60%；The Semen Cuscutae extract
Refer to the alcohol extract of Semen Cuscutae, general flavone content is no less than 60%.
The auxiliary material includes the component of following parts by weight：30-60 parts of dextrin, 1-3 parts of sodium carboxymethylcellulose, magnesium stearate
2-4 parts.
Embodiment 2
A kind of alleviation physical fatigue Chinese medicine health-care composition of the present invention includes the component of following weight：American Ginseng
80-150 parts, it is 30-60 parts of cervus elaphus linnaeus, 30-70 parts of Semen Cuscutae extract, 30-70 parts of ophiopogon japonicus extract, 1 part of function and service agent, auxiliary
0.2-1 parts of material；
The function and service agent is benefiting qi and nourishing blood agent, includes the component of following weight：20-30 parts of Radix Astragali, Radix Angelicae Sinensis
6-9 parts, 10-20 parts of jujube, 10-20 parts of matrimony vine；
The ophiopogon japonicus extract refers to the water extract of Radix Ophiopogonis, and total starches content is no less than 60%；The Semen Cuscutae extract
Refer to the alcohol extract of Semen Cuscutae, general flavone content is no less than 60%.
The auxiliary material includes the component of following parts by weight：27 parts of Icing Sugar, 8 parts of PVP K30.
Embodiment 3
A kind of alleviation physical fatigue Chinese medicine health-care composition of the present invention includes the component of following weight：American Ginseng
80-150 parts, it is 30-60 parts of cervus elaphus linnaeus, 30-70 parts of Semen Cuscutae extract, 30-70 parts of ophiopogon japonicus extract, 1 part of function and service agent, auxiliary
0.2-1 parts of material；
The function and service agent is Anshen Bunao agent, includes the component of following weight：30-40 parts of spina date seed, when
Return 20-30 parts, 10-15 parts of lotus seeds, 20-30 parts of sealwort；
The ophiopogon japonicus extract refers to the water extract of Radix Ophiopogonis, and total starches content is no less than 60%；The Semen Cuscutae extract
Refer to the alcohol extract of Semen Cuscutae, general flavone content is no less than 60%.
The auxiliary material includes the component of following parts by weight：30-60 parts of dextrin, 1-3 parts of sodium carboxymethylcellulose, magnesium stearate
2-4 parts.
Embodiment 4
A kind of alleviation physical fatigue Chinese medicine health-care composition of the present invention includes the component of following weight：American Ginseng
80-150 parts, it is 30-60 parts of cervus elaphus linnaeus, 30-70 parts of Semen Cuscutae extract, 30-70 parts of ophiopogon japonicus extract, 1 part of function and service agent, auxiliary
0.2-1 parts of material；
The function and service agent is strengthening spleen and nourishing stomach agent, includes the component of following weight：10-15 parts of Rhizoma Atractylodis Macrocephalae, Poria cocos
10-15 parts, 7-9 parts of Radix Glycyrrhizae.
The ophiopogon japonicus extract refers to the water extract of Radix Ophiopogonis, and total starches content is no less than 60%；The Semen Cuscutae extract
Refer to the alcohol extract of Semen Cuscutae, general flavone content is no less than 60%.
The auxiliary material includes the component of following parts by weight：30-60 parts of dextrin, 1-3 parts of sodium carboxymethylcellulose, magnesium stearate
2-4 parts.
Embodiment 5
A kind of alleviation physical fatigue Chinese medicine health-care composition of the present invention includes the component of following weight：American Ginseng
120 parts, 45 parts of cervus elaphus linnaeus, 50 parts of Semen Cuscutae extract, 50 parts of ophiopogon japonicus extract, 0.2 part of auxiliary material；
The ophiopogon japonicus extract refers to the water extract of Radix Ophiopogonis, and total starches content is no less than 60%；The Semen Cuscutae extract
Refer to the alcohol extract of Semen Cuscutae, general flavone content is no less than 60%.
The auxiliary material includes the component of following parts by weight：30 parts of dextrin, 1-3 parts of sodium carboxymethylcellulose, magnesium stearate 3
Part.
Embodiment 6
A kind of alleviation physical fatigue Chinese medicine health-care composition of the present invention includes the component of following weight：American Ginseng
80 parts, 30 parts of cervus elaphus linnaeus, 30 parts of Semen Cuscutae extract, 30 parts of ophiopogon japonicus extract, 0.6 part of auxiliary material；
The ophiopogon japonicus extract refers to the water extract of Radix Ophiopogonis, and total starches content is no less than 60%；The Semen Cuscutae extract
Refer to the alcohol extract of Semen Cuscutae, general flavone content is no less than 60%.
The auxiliary material includes the component of following parts by weight：27 parts of Icing Sugar, 8 parts of PVP K30.
Embodiment 7
A kind of alleviation physical fatigue Chinese medicine health-care composition of the present invention includes the component of following weight：American Ginseng
150 parts, 60 parts of cervus elaphus linnaeus, 70 parts of Semen Cuscutae extract, 70 parts of ophiopogon japonicus extract, 1 part of auxiliary material；
The ophiopogon japonicus extract refers to the water extract of Radix Ophiopogonis, and total starches content is no less than 60%；The Semen Cuscutae extract
Refer to the alcohol extract of Semen Cuscutae, general flavone content is no less than 60%.
The auxiliary material includes the component of following parts by weight：30 parts of dextrin, 1-3 parts of sodium carboxymethylcellulose, magnesium stearate 3
Part.
The raw material adds in auxiliary material and tablet, capsule, aqua or paste is made through corresponding technique.
Preparation method of the present invention uses half medicinal extract tabletting, but medicinal extract amount is less, and American Ginseng and cervus elaphus linnaeus are poor for fine powder viscosity, examine
The molding quality requirement of coating tablet can be met by considering the suitable adhesive of addition, diluent, lubricant.It attempts to have used in experiment more
Kind adhesive, discovery are easier to pelletize, and sodium carboxymethylcellulose is thick using sodium carboxymethylcellulose ethanol solution as adhesive
There is larger tessellation between rough structure and fine powder, increase bond strength, the compressibility of tablet can be improved, improve hardness light
Cleanliness, while drying time is short, volatile removing ethyl alcohol, therefore dosage, concentration are investigated, from softwood situation, granulation
Situation, particle appearance, yield several respects account for it, and it is best preferably to go out 3% sodium carboxymethylcellulose ethanol solution.It adopts
Make adhesive with different ethanol concentration PVP K30 aqueous solution, reduced with concentration of alcohol, disintegration is accelerated, wetting agent using 50%,
60%th, 70% ethyl alcohol is tested, and determining alcohol is unilateral when reducing easily to go out aobvious spot, difference of hardness when determining alcohol is high, therefore selects 60% second
Alcohol；Disintegration is reduced with povidone dosage to accelerate.
It is mainly several from tabletting sticking, smooth appearance, hardness, friability, disintegration time limited, angle of repose to the selection of lubricant
Index is investigated, and final choice magnesium stearate presses plain piece optimal quality when mass fraction is 1% or so during total drug forms.This
Directly it is used as medicine for medicinal powder in pharmaceutical composition, and accounts for the large percentage in formula, viscosity is poor, therefore this product selects dextrin
Enhance adhesiveness for diluent, while using Icing Sugar.Through experiment, when dextrin dosage, mass fraction is 15% in total drug composition
Constantly, sample powder mobility is preferable for left and right.Therefore the dextrin that dosage is 15% is selected as diluent.
Tablets preparation method example 1
A kind of preparation method for alleviating physical fatigue Chinese medicine health-care composition, includes the following steps：
It weighs：Each raw material are weighed according to the weight；
It pulverizes and sieves：Semen Cuscutae extract is taken to be uniformly mixed with ophiopogon japonicus extract, obtains mixture A；By each traditional Chinese medicinal components point
It does not crush, sieves with 100 mesh sieve, obtain traditional Chinese medicinal components fine powder, mixture A with traditional Chinese medicinal components fine powder is uniformly mixed, obtains mixture B；
Mixing granulation：27 parts, 8 parts PVP K30s of mixture B and Icing Sugar are uniformly mixed, obtain mixed powder C.To mixed powder C
60% ethanol solution softwood of middle addition, 20 mesh screens are pelletized, and are dried below 50 DEG C of wet granular, and powder moisture is controlled 4.0%
~6.0%, 18 mesh sieve whole grain；
Tabletting encapsulates：It adds in 0.5% magnesium stearate to be uniformly mixed, tabletting, then be coated with stomach dissolved film coating pre-mix dose,
Packaging to get.
Tablets preparation method example 2
A kind of preparation method for alleviating physical fatigue Chinese medicine health-care composition, includes the following steps：
It weighs：Each raw material are weighed according to the weight；
It pulverizes and sieves：Semen Cuscutae extract is taken to be uniformly mixed with ophiopogon japonicus extract, obtains mixture A；By each traditional Chinese medicinal components point
It does not crush, sieves with 100 mesh sieve, obtain traditional Chinese medicinal components fine powder, mixture A with traditional Chinese medicinal components fine powder is uniformly mixed, obtains mixture B；
Mixing granulation：30 parts of dextrin, mixing are added in into mixed powder B, with 3% carboxymethylcellulose sodium solution softwood,
20 mesh screens are pelletized, and are dried below 60 DEG C of wet granular, and the control of powder moisture sieves whole grain in 4.0%~6.0%, 18 mesh；
Tabletting encapsulates：It adds in magnesium stearate to be uniformly mixed, tabletting, then is coated, packed with stomach dissolved film coating pre-mix dose,
To obtain the final product.
3% carboxymethylcellulose sodium solution refers to the sodium carboxymethylcellulose ethanol solution that mass fraction is 3%.
The preparation method example 3 of capsule of the present invention
A kind of preparation method for alleviating physical fatigue Chinese medicine health-care composition, includes the following steps：
It weighs：Each raw material are weighed according to the weight；
It pulverizes and sieves：Semen Cuscutae extract is taken to be uniformly mixed with ophiopogon japonicus extract, obtains mixture A；By each traditional Chinese medicinal components point
It does not crush, sieves with 100 mesh sieve, obtain traditional Chinese medicinal components fine powder, mixture A with traditional Chinese medicinal components fine powder is uniformly mixed, obtains mixture B；
Mixing granulation：30 parts of dextrin is added in into mixed powder B, with 3% carboxymethylcellulose sodium solution softwood, 20 mesh sieve
Net granulation, is dried below 60 DEG C of wet granular, and control moisture crosses 18 mesh and sieves whole grain 4.0%~6.0%；
Encapsulation：Capsule charge, pack to get.
Experimental example 1：Function of physical fatigue alleviation is tested
1st, experiment material
1.1 experimental animal：Kunming mouse, weight 18-22g, every group 15.
1.2 sample：The tablet being prepared according to the method described above, specification：0.3g/ pieces.The tablet is by following preferred
The raw material composition of weight proportion：It is 120 parts of American Ginseng, 45 parts of cervus elaphus linnaeus, 50 parts of Semen Cuscutae extract, 50 parts of ophiopogon japonicus extract, auxiliary
1 part of material.
1.3 function of physical fatigue alleviation are tested
1.3.1 swimming with a load attached to the body is tested
If high, medium and low (1.5g/Kg.BW, 1.0g/Kg.BW, 0.5g/Kg.BW) dosage group and control group, successive administration 30
My god, after last dose 30min, bear a heavy burden 5% weight sheet lead for mouse tail root, is placed in swimming trunk went swimming.Record mouse swimming is opened
Begin to the death time.
| Group | Swimming time S | P values |
| Control group | 274±35 | - |
| Low dose group | 496±101 | 0.000 |
| Middle dose group | 493±110 | 0.000 |
| High dose group | 468±92 | 0.000 |
Experimental group and control group through mean value two-by-two compared with, the swimming time of basic, normal, high dosage group is obviously prolonged than control group
And significant difference (P<0.05).
1.3.2 serum urea measures
If high, medium and low (1.5g/Kg.BW, 0.5g/Kg.BW, 0.25g/Kg.BW) dosage group and control group, successive administration
30 days, after last dose 30min, in temperature in 30 DEG C of water, not swimming with a load attached to the body 90min, rest 60min posterior orbits are taken a blood sample about
0.5ml, is placed in refrigerator about 3h, and blood clotting centrifuging and taking serum measures urea nitrogen.
| Group | Urea nitrogen content mol/L | P values |
| Control group | 4.00±0.36 | - |
| Low dose group | 4.09±0.43 | 0.554 |
| Middle dose group | 4.04±0.46 | 0.787 |
| High dose group | 4.05±0.48 | 0.745 |
Serum urea nitrogen content there was no significant difference (P between each dosage group>0.05).
1.3.3 liver glycogen original measures
If high, medium and low (1.5g/Kg.BW, 0.5g/Kg.BW, 0.25g/Kg.BW) dosage group and control group, successive administration
30 days, after last dose 30min, animal is put to death, liver is taken to carry out the measure of hepatic glycogen.
| Group | Hepatic glycogen content mg/100g livers | P values |
| Control group | 2461±498 | - |
| Low dose group | 5284±672 | 0.000 |
| Middle dose group | 5862±705 | 0.000 |
| High dose group | 5403±843 | 0.000 |
Experimental group and control group two-by-two compared with, the hepatic glycogen of basic, normal, high dosage group has than control group apparent increase
Pole significant difference (P<0.01).
1.3.4 blood lactase acid measures
If high, medium and low (1.5g/Kg.BW, 0.5g/Kg.BW, 0.25g/Kg.BW) dosage group and control group, successive administration
30 days, after last dose 30min, blood sampling, after do not bear a heavy burden after temperature 30 water went swimming 10min, 20min, measure blood breast respectively
Area under acid and blood lactase acid.
| Group | Before movement | 10min after movement | 20min after movement | Lactic acid area under the curve | P values |
| Control group | 4.15±1.37 | 9.18±0.95 | 5.17±0.91 | 210.1±17.9 | - |
| Low dose group | 3.48±0.84 | 8.98±0.96 | 4.07±1.82 | 192.9±28.0 | 0.025 |
| Middle dose group | 2.54±0.67 | 8.76±0.85 | 5.34±0.73 | 197.5±18.5 | 0.099 |
| High dose group | 3.62±0.92 | 7.62±0.88 | 3.95±0.63 | 171.9±15.1 | 0.000 |
Experimental group and control group through mean value two-by-two compared with, the blood lactase acid area under the curve drop more apparent than control group of high dose group
Low and significant difference (P<0.05).
In summary, composition provided by the invention is non-toxic, has strengthen immunity, function of relieving physical fatigue.
Experimental example 2：Anti-oxidation function is tested
This test is by measuring MDA contents in mice serum, superoxide dismutase (SOD) and glutathione peroxidase
The vigor of enzyme (GSH-Px) has carried out the effect of the present invention to do oxidative function test.
8-12 month mouse, control group gavage vegetable oil are chosen, dosage group presses various dose continuous gavage test medicine 30 days
Afterwards, it measures.
The influence of 2.1 pairs of mice serum MDA contents
It is continuous tested if high, medium and low (1.5g/Kg.BW, 0.5g/Kg.BW, 0.25g/Kg.BW) dosage group and control group
After take a blood sample and detach serum, measure MDA contents.
| Group | Serum MDA (mol/ml) | P values |
| Control group | 11.71±4.44 | - |
| Low dose group | 11.85±3.19 | 0.922 |
| Middle dose group | 10.74±3.67 | 0.485 |
| High dose group | 8.49±3.78 | 0.024 |
Experimental group and control group through mean value two-by-two compared with, the significant difference (P of high dose group<0.05), show that this product has
Play the role of reducing MDA in mouse blood.
The influence of SOD vigor in 2.2 pairs of mice serums
It is continuous tested if high, medium and low (1.5g/Kg.BW, 0.5g/Kg.BW, 0.25g/Kg.BW) dosage group and control group
After take a blood sample and detach serum, measure SOD contents.
| Group | SOD in serum (U/ml) | P values |
| Control group | 173.17±19.28 | - |
| Low dose group | 182.46±14.51 | 0.239 |
| Middle dose group | 196.16±22.17 | 0.005 |
| High dose group | 265.44±27.43 | 0.000 |
Experimental group and control group through mean value two-by-two compared with, the middle and high significant difference (P of dosage group<0.05), high dose group
There is pole significant difference (P<0.01) show that this product has the function of to increase SOD vigor in mice serum.
The influence of GSH-Px vigor in 2.3 pairs of mice serums
It is continuous tested if high, medium and low (1.5g/Kg.BW, 0.5g/Kg.BW, 0.25g/Kg.BW) dosage group and control group
After take a blood sample and detach serum, measure GSH-Px contents.
| Group | GSH-Px in serum (U/ml) | P values |
| Control group | 228.84±10.54 | - |
| Low dose group | 264.42±18.48 | 0.000 |
| Middle dose group | 272.22±14.59 | 0.000 |
| High dose group | 297.43±13.31 | 0.000 |
Experimental group and control group through mean value two-by-two compared with, basic, normal, high dosage group has pole significant difference (P<0.01) show
This product has the function of to increase GSH-P vigor in mice serum.
The present invention is not limited by embodiment illustrated herein, and is to fit to and principles disclosed herein and novelty
The consistent widest range of feature.
Claims (6)
1. a kind of alleviation physical fatigue Chinese medicine health-care composition, which is characterized in that include the component of following weight：The West
80-150 parts of ginseng, 30-60 parts of cervus elaphus linnaeus, 30-70 parts of Semen Cuscutae extract, 30-70 parts of ophiopogon japonicus extract, function and service agent 0-1
Part；
The function and service agent is one or both of benefiting qi and nourishing blood agent, Anshen Bunao agent, strengthening spleen and nourishing stomach agent；
The benefiting qi and nourishing blood agent includes the component of following weight：20-30 parts of Radix Astragali, 6-9 parts of Radix Angelicae Sinensis, 10-20 parts of jujube,
10-20 parts of matrimony vine；
The Anshen Bunao agent includes the component of following weight：30-40 parts of spina date seed, 20-30 parts of Radix Angelicae Sinensis, lotus seeds 10-
15 parts, 20-30 parts of sealwort；
The strengthening spleen and nourishing stomach agent includes the component of following weight：10-15 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of Poria cocos, 7-9 parts of Radix Glycyrrhizae.
A kind of 2. alleviation physical fatigue Chinese medicine health-care composition as described in claim 1, which is characterized in that the Radix Ophiopogonis extraction
Object refers to the water extract of Radix Ophiopogonis, and total starches content is no less than 60%；The Semen Cuscutae extract refers to the alcohol extract of Semen Cuscutae, always
Flavones content is no less than 60%.
3. a kind of alleviation physical fatigue Chinese medicine health-care composition as described in claim 1, which is characterized in that further include parts by weight
For 0.2-1 parts of auxiliary material；The auxiliary material includes the component of following parts by weight：30-60 parts of dextrin, 1-3 parts of sodium carboxymethylcellulose,
2-4 parts of magnesium stearate.
A kind of 4. alleviation physical fatigue Chinese medicine health-care composition as described in any one of claims 1-3, which is characterized in that the original
Material adds in auxiliary material through tablet, capsule, aqua or paste made from corresponding technique.
5. a kind of preparation method for alleviating physical fatigue Chinese medicine health-care composition, special as described in claim 1-3 any one
Sign is, includes the following steps：
It weighs：Each raw material are weighed according to the weight；
It pulverizes and sieves：Semen Cuscutae extract is taken to be uniformly mixed with ophiopogon japonicus extract, obtains mixture A；Each traditional Chinese medicinal components are distinguished into powder
It is broken, it sieves with 100 mesh sieve, obtains traditional Chinese medicinal components fine powder, mixture A with traditional Chinese medicinal components fine powder is uniformly mixed, obtains mixture B；
Mixing granulation：30 parts of dextrin, mixing are added in into mixed powder B, with 3% carboxymethylcellulose sodium solution softwood, 20 mesh
Sieve is pelletized, and is dried below 60 DEG C of wet granular, and the control of powder moisture sieves whole grain in 4.0%~6.0%, 18 mesh；
Tabletting encapsulates：It adds in magnesium stearate to be uniformly mixed, tabletting, then is coated, packed with stomach dissolved film coating pre-mix dose, i.e.,
.
6. a kind of preparation method for alleviating physical fatigue Chinese medicine health-care composition as claimed in claim 5, which is characterized in that described
3% carboxymethylcellulose sodium solution refers to the sodium carboxymethylcellulose ethanol solution that mass fraction is 3%.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101147580A (en) * | 2007-08-16 | 2008-03-26 | 陈辉瑞 | New functional health-care food 'health preserving' granule capable of reinforcing vitality and strengthening physique |
| JP2012012336A (en) * | 2010-06-30 | 2012-01-19 | Rohto Pharmaceutical Co Ltd | Solid preparation for oral administration |
| CN103800661A (en) * | 2014-01-10 | 2014-05-21 | 北京同仁堂健康药业股份有限公司 | Composition for improving immunity and relieving physical fatigue and preparation thereof |
-
2018
- 2018-03-29 CN CN201810276159.4A patent/CN108186879A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101147580A (en) * | 2007-08-16 | 2008-03-26 | 陈辉瑞 | New functional health-care food 'health preserving' granule capable of reinforcing vitality and strengthening physique |
| JP2012012336A (en) * | 2010-06-30 | 2012-01-19 | Rohto Pharmaceutical Co Ltd | Solid preparation for oral administration |
| CN103800661A (en) * | 2014-01-10 | 2014-05-21 | 北京同仁堂健康药业股份有限公司 | Composition for improving immunity and relieving physical fatigue and preparation thereof |
Non-Patent Citations (1)
| Title |
|---|
| 国家药典委员会: "《中华人民共和国药典临床用药须知：2015年版.中药饮片卷"，国家药典委员会》", 30 September 2017, 中国医药科技出版社 * |
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Application publication date: 20180622 |