CN108186876A - A kind of Chinese medicine composition for having the function of to reduce blood glucose and preparation method thereof - Google Patents
A kind of Chinese medicine composition for having the function of to reduce blood glucose and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compositions for having the function of to reduce blood glucose, are made of following weight percent composition：Radix Astragali 26~30%, Radix Ophiopogonis 24~28%, pueraria lobata 22~26%, cordate houttuynia 20~24%.Also disclose the preparation method of the Chinese medicine composition.The present invention is according to theory of traditional Chinese medical science diagnosis and treatment based on an overall analysis of the illness and the patient's condition, whole conditioning, it chooses Chinese medicine of the pharmacological property than shallower medicine-food two-purpose or available for health food and carries out reasonable formula, scientific compatibility, and employ advanced extraction separation and purification method and the active ingredient in Chinese medicine is extracted to greatest extent and removes non-active ingredients, product is made to be provided with the function of blood sugar reduction of highly significant.The composition safety economy, curative for effect, production process is simple, conditional stability, is suitble to scale industrial production.
Description
Technical field：
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition and its system for having the function of to reduce blood glucose
Preparation Method.
Background technology：
Diabetes are to threaten the common chronic disease of human health, and diabetic is prevalent in vast social crowd.
In recent years, physical resources are increasingly abundanter, and manual labor amount is fewer and fewer, and fat, diabetic's number increases year by year.
On March 6th, 2016, World Health Organization show global diabetes adult patient nearly 40 years in issuing global diabetes report for the first time
3 times are inside increased, wherein majority lives in developing country.Report display, Chinese adult suffer from diabetes rate close to 10%.
At present for the treatment of diabetes, it is widely used there are many chemicals.But due to these chemicals
The substance of non-body active absorption can promptly be excluded, therefore be merely capable of playing limited treatment after administration by body
Value.In order to obtain desired therapeutic effect, dosage must be just increased, strong dose object can cause the negative anti-of body again
Feedback reduces the effect of drug.
Also have currently on the market much for the Chinese medicine of hypoglycemic, but the drug hypoglycemic effect having is not very definitely also one
A little Chinese medicine antihypelipidemic product prescriptions are cumbersome, big industrial production there are production complexity it is big the problem of, diabetic is in recognizing
After drug is learned to the harm of human body and palliative situation, traditional Chinese medical herbal treatment is increasingly advocated, but as people live
The quickening of rhythm, the diagnosis and treatment based on an overall analysis of the illness and the patient's condition of the traditional Chinese medical science tanning decoction of medicinal ingredients for preparing medicines from a Chinese precription allow people to feel inconvenient.
The traditional Chinese medical science was also especially more for the research of the theory and mechanism of diabetes in recent years, although without certain final conclusion,
Compare accreditation in the traditional Chinese medical science be known as " diabete " several partings have Yin Xu Nei Re Zheng, damp and hot tired spleen card, syndrome of deficiency of both qi and yin,
Syndrome of deficiency of both yin and yang, blood stasis train of thought card etc., the Chinese medicine that single medicinal material has blood sugar reducing function in the prior art is planted up to more than 70, but is used
Single medicinal material is with regard to that can reach the Chinese medicine of good hypoglycemic effect also almost without how according to the type of disease, by Chinese medicine
Select, rational ratio compatibility and by suitable method for extraction and purification improve active ingredient content simultaneously remove in vain
Ingredient and invent it is a kind of for tcm symptom parting, having exact function of polysaccharide, formula is simple, has no toxic side effect
, Chinese medicine composition be just particularly important, thus facilitate patient according to tcm symptom parting selection targetedly, curative effect
More exact Chinese medicine antihypelipidemic product.
Invention content：
For these reasons, the present inventor, with reference to clinical practice of Chinese medicine, has carried out a system based on Traditional Chinese medical theory
The theory to type II diabetes and basic research are arranged, and is attended by the most momentous results, according to traditional Chinese medicine aspect type of deficiency of both QI and YIN II type sugar
Urinate the etiology and pathogenesis of disease：Internal organs deficient qi and blood, imbalance of yin and yang are the causes of disease, and deficiency of vial QI, transporting is incompetent, and physiological metabolism is not normal, cloudy
The fire of deficiency type is prosperous, consumes liquid and hinders Tianjin, researchs and develops with economic security, integration of drinking and medicinal herbs or the Radix Astragali available for health food, Radix Ophiopogonis, Pueraria lobota
Root, cordate houttuynia for primary raw material, through composition made of modern process for extracting, separating and purifying, it is curative for effect, be suitable for gas the moon two
Deficiency patients with NIDDM is taken, economic security, and manufacturing condition is stablized, and is suitble to scale industrial production.
The purpose of the present invention is to provide a kind of Chinese medicine composition for having the function of to reduce blood glucose, the raw material of the composition is equal
Chinese medicine for integration of drinking and medicinal herbs or available for health food, prescription are scientific and reasonable and synergistic.
Another object of the present invention is to provide a kind of preparation side for the Chinese medicine composition for having the function of to reduce blood glucose
Method, Chinese medicine composition made from this method have the function of to significantly decrease blood glucose.
In order to achieve the above objectives, the present invention uses the component of following weight percents：
Radix Astragali 26~30%, Radix Ophiopogonis 24~28%, pueraria lobata 22~26%, cordate houttuynia 20~24%.
Preferably, the present invention uses the component of following weight percents：
Radix Astragali 27~29%, Radix Ophiopogonis 25~27%, pueraria lobata 23~25%, cordate houttuynia 21~23%.
It is further preferred that the present invention uses the component of following weight percents：
Radix Astragali 28%, Radix Ophiopogonis 26%, pueraria lobata 24%, cordate houttuynia 22%.
The preparation method of Chinese medicine composition of the present invention includes the following steps：
(1) Radix Astragali, Radix Ophiopogonis, pueraria lobata, cordate houttuynia are taken, extracting in water 2 times adds in 8~10 times of amount water, 90 DEG C of temperature for the first time
~100 DEG C are kept for 1~2 hour, filtering；Second of addition, 6~8 times of amount water, 90 DEG C~100 DEG C of temperature are kept for 0.5~1 hour,
Filtering, merging filtrate；
(2) macroporous absorbent resin on filtrate, respectively with the elution for the first time of 30%~50% ethyl alcohol, 75%~90% ethyl alcohol the
Eluent is collected in secondary elution；
(3) 0.01~0.09Mpa of steam pressure, vacuum degree -0.03~-0.08Mpa, 60~80 DEG C of temperature are concentrated into 50
~55 DEG C measure the medicinal extract that relative density is 1.26~1.30；
(4) vacuum degree -0.04~-0.09Mpa, 60~80 DEG C of temperature, dry, pulverize 60 mesh sieve to get.
Preferably, ethanol eluate volumetric concentration is respectively in step (2)：For the first time 35%~45%；Second 80%
~90%.
It is further preferred that ethanol eluate volumetric concentration is respectively：For the first time 40%；Second 85%.
Preferably, the water of 6 times of amounts are added in step (2), are 1800MHz in microwave frequency, stirring frequency is the item of 4r/min
Under part, extract 60 minutes；
Preferably, 0.04~0.07Mpa of steam pressure in step (3), vacuum degree -0.04~-0.06Mpa, temperature 65~
It 75 DEG C, is concentrated into 50~55 DEG C and measures the medicinal extract that relative density is 1.26~1.30.
It is further preferred that steam pressure 0.05Mpa in step (3), vacuum degree -0.06Mpa, temperature 70 C are concentrated into
55 DEG C measure the medicinal extract that relative density is 1.26.
Preferably, it is 3.5~5.5% to be dried in step (4) to water content.
The present invention composition, can with auxiliary material in one or more kinds of pharmacies for example starch, dextrin, microcrystalline cellulose,
Hypromellose, polyethylene glycol, magnesium stearate, superfine silica gel powder, etc. the various dosage forms that are mixed, for example, can be made into piece
Agent, dripping pill, granule, capsule, fine granule.
The present invention has selected very safe, pharmacological property to compare the integration of drinking and medicinal herbs of mitigation or can be used for from the angle of traditional Chinese medicine
The Chinese medicine of health food using Radix Astragali help vigour and promotes the production of body fluid to quench thirst, and Radix Ophiopogonis nourishing Yin and promoting production of body fluid nourishing kidney yin, pueraria lobata promotes the production of body fluid to quench thirst simultaneous
Having rising Yang, cordate houttuynia plays prevents flaring up of deficient fire while help, and all medicines share goes back to the cloudy multiple Tianjin of gas life, water-ascending and fire-descending, and five
Dirty peacefulness, the benefits of playing supplementing qi and nourishing yin altogether.
Test example：
Below by clinical testing data, the advantageous effect further illustrated the present invention：
1 animal experiment
1.1 test method：SD rats 140 are taken, weight 180-220g, 10 give over to Normal group, feed chow diet.
Remaining 130 rat for being served only for modeling gives high glucose and high fat feed, induced insulin resists mould after three days adaptability cultivates
Type.After feeding 8 weeks, by the Rat Fast 12h of high sugar feed nursing, the STZ liquid (25mg/kg) of Fresh is injected intraperitoneally, after
It after continuous high-sugar-fat-diet feeds 72h, cuts tail and measures fasting blood sugar, be diabetic animal models modeling more than 11.1mmol/L
Success.
There are 116 rat modeling successes through examining, select 110 into mould rat, it is right to be randomly divided into model control group, the positive
According to group and test group (being divided into 9 groups, respectively test 1 group to 9 groups of experiment), the Chinese traditional medicine composition that 1 group of gavage embodiment 1 of experiment obtains
Object, the Chinese medicine composition that 2 groups of gavage embodiments 2 of experiment obtain, the Chinese medicine composition that 3 groups of gavage embodiments 3 of experiment obtain, experiment
4 groups of gavage Radix Astragali 350g, Radix Ophiopogonis 200g, pueraria lobata 300g, cordate houttuynia 150g are according to composition made from 3 method of embodiment, experiment 5
Group gavage Radix Astragali 345g, Radix Ophiopogonis 310g, pueraria lobata 345g test 6 groups of gavage Radix Ophiopogonis according to composition made from 3 method of embodiment
370g, pueraria lobata 330g, cordate houttuynia 300g test 7 groups of gavage Radix Astragali 390g, pueraria lobatas according to composition made from 3 method of embodiment
320g, cordate houttuynia 290g test 8 groups of gavage Radix Astragali 370g, Radix Ophiopogonis 340g, fish raw meats according to composition made from 3 method of embodiment
Careless 290g tests 9 groups of gavage Radix Astragali 280g, Radix Ophiopogonis 260g, pueraria lobata 240g, fish raw meats according to composition made from 3 method of embodiment
Careless 220g, twice, 8 times of amount water 1h, second of 6 times of amount water 1h for the first time, merging filtrate concentration are dried under vacuum to and contain extracting in water
Water is composition made from 4.2%, and the dosage of 1 group of experiment extremely 9 groups of experiment is 0.1g/kg/d.Positive controls gavage salt
Sour melbine, dosage 0.1g/kg/d.The drinking water of Normal group and model control group gavage corresponding dosage, except normal
Outside control group, other continue to feed high glucose and high fat feed.By the daily gavage of rat 2 times, continuous gavage 6 weeks cuts tail blood sampling, respectively
Measure rat fasting blood-glucose, feed 2h blood glucose.
After continuous gavage 6 weeks, rat femoral is taken a blood sample, measures serum insulin level.Dislocation is put to death, and takes liver at once
Be placed in ice bath, and cleaned with physiological saline, filter paper is wiped dry, weigh appropriate, it is 100mg/ that mass concentration, which is made, with ice physiological saline
0.5mL liver homogenates are measured for hepatic glycogen content.
1.2 observation items and index：Fasting blood-glucose and feed 2h blood glucose are measured before experiment and after experiment respectively；Off-test
Serum insulin content, hepatic glycogen content are measured afterwards.
1.3 statistical procedures：Measurement data mean ± standard deviationIt represents, is examined using t and carry out statistical
Analysis.
1.4 result
1.4.1 each rats in test groups fasting blood-glucose and 2h-plasma glucose testing result are shown in Table 1.
1 blood glucose test results of table
Note：In group compared with before experiment, * P ＜ 0.05, * * P ＜ 0.01；Compared with testing 4 groups to 9 groups of experiment, △ P ＜
0.05。
As shown in Table 1, before 4 groups of experiment is relatively tested to fasting blood-glucose content after 9 groups of experiments of experiment and 2h-plasma glucose content
It is significantly reduced (P ＜ 0.05), difference has conspicuousness；1 group is tested to fasting blood-glucose content and meal after 3 groups of experiments of experiment
2h blood-sugar contents have highly significant reduction (P ＜ 0.01) afterwards before relatively testing, and difference has extremely conspicuousness；Test 1 group extremely
Test 3 groups is reducing fasting blood-glucose content and 2h-plasma glucose content no significant difference (P ＞ 0.05) with positive controls.Explanation
Composition made from raw material proportioning and preparation method of the present invention is compared with group made from other compositions or other proportionings and other methods
Closing object has the function of more significantly to reduce blood glucose, synergistic between component, the present composition is made to reduce blood glucose function true
It cuts.
1.4.2 influence of each test group to diabetes rat serum insulin and hepatic glycogen content the results are shown in Table 2.
Influence of the 2 each test group of table to diabetes rat serum insulin and hepatic glycogen content
Note：Compared with model group, * P ＜ 0.05, * * P ＜ 0.01；Compared with testing 4 groups to 9 groups of experiment, △ P ＜ 0.05
As shown in Table 2, compared with model group serum insulin content, 1 group of experiment goes out to 3 groups of serum insulin contents are tested
Significant difference (P ＜ 0.05) is presented in now apparent ascendant trend；With the increase of insulin content, rat hepatic glycogen content also goes out
Now increase trend, extremely significant difference (P ＜ 0.01) is presented, illustrates that the present composition can promote the synthesis of hepatic glycogen.And
4 groups of extremely 9 groups of experiments are tested to be increased slightly in serum insulin content and hepatic glycogen content, but that significant difference (P ＞ are not presented
0.05).Illustrate composition made from raw material proportioning and preparation method of the present invention compared with other compositions or other proportionings and its other party
Composition made from method has the function of to improve serum insulin content and hepatic glycogen content.
2 human trials
2.1 general information：The physical examination result of XX units in November, 2017 medical examiner, according to doctor trained in Western medicine standard screening fasting blood
The personnel of sugared value >=7.0mmol/L and≤11.0mmol/L, as this experiment of volunteer's voluntary participation, applicant is promised to undertake to aspiration
The data of person maintains secrecy.Further screening on this basis meets related glycosuria in diabetes mellitus in China guideline of prevention and treatment in 2017
Disease diagnosis and parting standard, are diagnosed as type II diabetes, and reference《New Chinese medicine guideline of clinical investigations》Meet gas the moon two
Empty dialectical standard, age are between 34~60 years old.
2.2 experiment groupings：According to 2.1 screening conditions, share 60 people and meet the requirements.Man 31, female 29, the age 35~
58 years old, average age 46.5 years old, the course of disease differed for 1 year to 16 years, average course of disease 8.6 years.60 people are divided into 5 groups, every group of 12 people into
Row experiment, the age of each group case, the course of disease, gender, the equal no significant difference of tcm symptom (P ＞ 0.05) are comparable.
2.3 test method：1 group of the present invention takes composition made from the embodiment of the present invention 1, each 6g, 3 times a day；This
It invents 2 groups and takes composition made from the embodiment of the present invention 2, each 6g, 3 times a day；3 groups of the present invention takes the embodiment of the present invention
Composition made from 3, each 6g, 3 times a day；It compares 1 group and takes commercially available diformin tablet, each 0.5g, 3 times a day；It is right
Commercially available glibenclamide is taken according to 2 groups, each 5mg, 2 times a day.Every group is taken 4 weeks.
2.4 observation items and index：
2.4.1 safety observations：1. general physical examination；2. blood, urine, feces routine test；3. the heart, Liver and kidney function inspection；
4. the adverse reaction being likely to occur during close observation medication.
2.4.2 health giving quality is observed：1. observe the situation of change of tcm symptom；2. empty stomach and postprandial 2 hours blood sugar tests, examination
It tests in beginning, end and experiment once a week；3. glycosylated hemoglobin detects, on-test, terminates each survey once.
Experiment case treats the last fortnight, rationally keeps on a diet, and deactivates hypoglycemic medicine, at the end of two weeks, measures on-test
Indices.
2.5 statistical procedures
Measurement data mean ± standard deviationIt represents, is examined using t for statistical analysis.
2.6 result
2.6.1 in the entire experiment process, 1 group, 2 groups and 3 groups of the present invention does not occur any adverse reaction.
2.6.2 tcm symptom (the primary symptom of syndrome of deficiency of both qi and yin：Dry throat, lassitude hypodynamia；Minor symptom：Polyorexia, thirsty happiness
Drink, shortness of breath lazyness speech, dysphoria in chestpalms-soles, palpitation and insomnia, red constipation of urinating.) improvement situation, be shown in Table 3.
3 each test group tcm symptom of table compares before and after treatment
Note：Present invention group is compared with 1 group of control, * P ＜ 0.05；Present invention group is compared with 2 groups of control, △ P ＜ 0.05
As shown in Table 3,1 group of the present invention to 3 groups of improvement to dry throat symptom of the invention better than 2 groups of (P ＜ of control
0.05), there was no significant difference (P ＞ 0.05) with compareing 1 group；1 group of the present invention is to 3 groups of improvement to thirst and liking drink symptom of the invention
Better than control 1 group (P ＜ 0.05), there was no significant difference (P ＞ 0.05) with compareing 2 groups；1 group to 3 groups of the invention of the present invention is to tired
The improvement of idle weak, polyorexia, shortness of breath lazyness speech, dysphoria in chestpalms-soles, palpitation and insomnia tcm symptom is with compareing 2 groups of 1 group, control phases
Than being respectively provided with significant difference (P ＜ 0.05).Of the present invention group is from Ben Yin, conditioning viscera, and effect is better than control group.
2.6.3 the detection numerical value of fasting blood-glucose is shown in Table 4.
The testing result of 4 fasting blood-glucose of table
Note：Compared with on-test, * P ＜ 0.05
As shown in Table 4, the present composition has significant difference (P ＜ in terms of fasting blood-glucose content before and after treatment
0.05), compared with 1 group of control, 2 groups of control, the present composition there was no significant difference in terms of fasting blood-glucose content (P ＞
0.05), illustrate that the present composition has the effect of substantially similar reduction fasting blood-glucose, work(to diformin tablet, glibenclamide
Effect is very definite.
2.6.4 postprandial 2 hours blood sugar test numerical value is shown in Table 5.
5 postprandial 2 hours blood glucose test results of table
Note：Compared with on-test, * P ＜ 0.05
As shown in Table 5, the present composition has significant difference (P ＜ in terms of 2h-plasma glucose content before and after treatment
0.05), of the present invention group compared with 1 group of control, 2 groups of control, there was no significant difference in terms of 2h-plasma glucose content (P ＞
0.05), illustrate that the present composition has the effect of substantially similar reduction 2h-plasma glucose to diformin tablet, glibenclamide,
Effect is very definite.
2.6.5 glycosylated hemoglobin detection numerical value is shown in Table 6.
6 glycosylated hemoglobin testing result of table
Note：Compared with on-test, * P ＜ 0.05
As shown in Table 6, the present composition has significant difference (P ＜ 0.05) in terms of HbA1c is reduced before and after treatment,
And compare 1 group, compare 2 groups compared to before and after treatment in terms of HbA1c is reduced without significant difference (P ＞ 0.05), illustrate this hair
Bright composition has effects that preferably reduction HbA1c is horizontal than diformin tablet, glibenclamide.
2.7 conclusion：It is above-mentioned experiments have shown that, the present composition have highly significant II type glycosuria of reduction type of deficiency of both QI and YIN
The effect of patient's blood glucose, and effect is better than melbine, glibenclamide, it is safely and effectively, without side-effects, be a kind of formula it is simple,
The Chinese medicine composition of hypoglycemic effect highly significant.
Specific embodiment
Embodiment 1
The preparation of Chinese medicine composition：(1) Radix Astragali 260g, Radix Ophiopogonis 240g, pueraria lobata 260g, cordate houttuynia 240g, extracting in water 2 are taken
It is secondary, 8 times of amount water are added in for the first time, and 90 DEG C of temperature is kept for 1 hour, filtering；Second of addition, 6 times of amount water, 90 DEG C of temperature keep 0.5
Hour, filtering, merging filtrate；(2) macroporous absorbent resin on filtrate, respectively with the elution for the first time of 30% ethyl alcohol, 75% ethyl alcohol the
Eluent is collected in secondary elution；(3) steam pressure 0.01Mpa, vacuum degree -0.03Mpa, temperature 60 C are concentrated into 50 DEG C and measure
Relative density is 1.30 medicinal extract；(4) vacuum degree -0.04Mpa, temperature 60 C, drying to water content are 3.5%, crushed 60
Mesh sieve to get.
Embodiment 2
The preparation of Chinese medicine composition：(1) Radix Astragali 300g, Radix Ophiopogonis 280g, pueraria lobata 220g, cordate houttuynia 200g, extracting in water 2 are taken
It is secondary, 10 times of amount water are added in for the first time, and 100 DEG C of temperature is kept for 2 hours, filtering；Second of addition, 8 times of amount water, 100 DEG C of holdings of temperature
1 hour, filtering, merging filtrate；(2) macroporous absorbent resin on filtrate, respectively with the elution for the first time of 50% ethyl alcohol, 90% ethyl alcohol the
Eluent is collected in secondary elution；(3) steam pressure 0.09Mpa, vacuum degree -0.08Mpa, 80 DEG C of temperature are concentrated into 55 DEG C and measure
Relative density is 1.26 medicinal extract；(4) vacuum degree -0.09Mpa, 80 DEG C of temperature, drying to water content are 5.5%, crushed 60
Mesh sieve to get.
Embodiment 3
The preparation of Chinese medicine composition：(1) Radix Astragali 280g, Radix Ophiopogonis 260g, pueraria lobata 240g, cordate houttuynia 220g, extracting in water 2 are taken
It is secondary, 9 times of amount water are added in for the first time, and 95 DEG C of temperature is kept for 1.5 hours, filtering；Second of addition, 7 times of amount water, 95 DEG C of holdings of temperature
0.75 hour, filtering, merging filtrate；(2) macroporous absorbent resin on filtrate is eluted, 85% second for the first time with 40% ethyl alcohol respectively
Second of elution of alcohol, collects eluent；(3) steam pressure 0.05Mpa, vacuum degree -0.06Mpa, temperature 70 C are concentrated into 52 DEG C
Measure the medicinal extract that relative density is 1.28；(4) vacuum degree -0.07Mpa, temperature 70 C, drying to water content are 4.2%, are crushed
Cross 60 mesh sieve to get.
Embodiment 4
The preparation of Chinese medicine composition：(1) Radix Astragali 260g, Radix Ophiopogonis 280g, pueraria lobata 260g, cordate houttuynia 200g, extracting in water 2 are taken
It is secondary, 8 times of amount water are added in for the first time, and 92 DEG C of temperature is kept for 2 hours, filtering；Second of addition, 8 times of amount water, 92 DEG C of holdings 1 of temperature are small
When, filtering, merging filtrate；(2) macroporous absorbent resin on filtrate is eluted, 80% ethyl alcohol second for the first time with 35% ethyl alcohol respectively
Eluent is collected in secondary elution；(3) steam pressure 0.03Mpa, vacuum degree -0.04Mpa, 65 DEG C of temperature are concentrated into 54 DEG C and measure phase
To the medicinal extract that density is 1.28；(4) vacuum degree -0.05Mpa, 65 DEG C of temperature, drying to water content are 4.5%, crushed 60 mesh
Sieve to get.
Embodiment 5
The preparation of Chinese medicine composition：(1) Radix Astragali 270g, Radix Ophiopogonis 270g, pueraria lobata 250g, cordate houttuynia 210g, extracting in water 2 are taken
It is secondary, 10 times of amount water are added in for the first time, and 98 DEG C of temperature is kept for 1 hour, filtering；Second of addition, 6 times of amount water, 98 DEG C of holdings of temperature
0.5 hour, filtering, merging filtrate；(2) macroporous absorbent resin on filtrate is eluted, 85% ethyl alcohol for the first time with 45% ethyl alcohol respectively
Second of elution, collects eluent；(3) steam pressure 0.08Mpa, vacuum degree -0.07Mpa, 75 DEG C of temperature are concentrated into 50 DEG C of surveys
Obtain the medicinal extract that relative density is 1.30；(4) vacuum degree -0.08Mpa, 75 DEG C of temperature, drying to water content are 5.2%, be crushed
60 mesh sieve to get.
Embodiment 6
The preparation of Chinese medicine composition：(1) Radix Astragali 290g, Radix Ophiopogonis 250g, pueraria lobata 230g, cordate houttuynia 230g, extracting in water 2 are taken
It is secondary, 9 times of amount water are added in for the first time, and 100 DEG C of temperature is kept for 1.5 hours, filtering；Second of addition, 8 times of amount water, 100 DEG C of guarantors of temperature
It holds 1 hour, filters, merging filtrate；(2) macroporous absorbent resin on filtrate is eluted, 90% ethyl alcohol for the first time with 50% ethyl alcohol respectively
Second of elution, collects eluent；(3) steam pressure 0.05Mpa, vacuum degree -0.06Mpa, 68 DEG C of temperature are concentrated into 55 DEG C of surveys
Obtain the medicinal extract that relative density is 1.26；(4) vacuum degree -0.06Mpa, temperature 70 C, drying to water content are 3.9%, be crushed
60 mesh sieve to get.
Embodiment 7
The preparation of Chinese medicine composition：(1) Radix Astragali 260g, Radix Ophiopogonis 260g, pueraria lobata 240g, cordate houttuynia 240g, extracting in water 2 are taken
It is secondary, 8 times of amount water are added in for the first time, and 90 DEG C of temperature is kept for 1 hour, filtering；Second of addition, 7 times of amount water, 90 DEG C of temperature keep 0.5
Hour, filtering, merging filtrate；(2) macroporous absorbent resin on filtrate, respectively with the elution for the first time of 30% ethyl alcohol, 75% ethyl alcohol the
Eluent is collected in secondary elution；(3) steam pressure 0.02Mpa, vacuum degree -0.03Mpa, 77 DEG C of temperature are concentrated into 53 DEG C and measure
Relative density is 1.27 medicinal extract；(4) vacuum degree -0.04Mpa, 75 DEG C of temperature, drying to water content are 4.8%, crushed 60
Mesh sieve to get.
Embodiment 8
The preparation of Chinese medicine composition：(1) Radix Astragali 300g, Radix Ophiopogonis 240g, pueraria lobata 250g, cordate houttuynia 210g, extracting in water 2 are taken
It is secondary, 9 times of amount water are added in for the first time, and 95 DEG C of temperature is kept for 1.5 hours, filtering；Second of addition, 7 times of amount water, 95 DEG C of temperature keep 1
Hour, filtering, merging filtrate；(2) macroporous absorbent resin on filtrate, respectively with the elution for the first time of 40% ethyl alcohol, 75% ethyl alcohol the
Eluent is collected in secondary elution；(3) steam pressure 0.09Mpa, vacuum degree -0.03Mpa, temperature 70 C are concentrated into 55 DEG C and measure
Relative density is 1.30 medicinal extract；(4) vacuum degree -0.09Mpa, temperature 70 C, drying to water content are 3.7%, crushed 60
Mesh sieve to get.
Claims (10)
1. a kind of Chinese medicine composition for having the function of to reduce blood glucose, is made of following weight percent composition：Radix Astragali 26~30%,
Radix Ophiopogonis 24~28%, pueraria lobata 22~26%, cordate houttuynia 20~24%.
2. Chinese medicine composition according to claim 1, which is characterized in that be made of following weight percent composition：Radix Astragali
27~29%, Radix Ophiopogonis 25~27%, pueraria lobata 23~25%, cordate houttuynia 21~23%.
3. Chinese medicine composition according to claim 1, which is characterized in that be made of following weight percent composition：Radix Astragali
28%, Radix Ophiopogonis 26%, pueraria lobata 24%, cordate houttuynia 22%.
4. a kind of preparation method of claim 1-3 any one of them Chinese medicine compositions, includes the following steps：
(1) Radix Astragali, Radix Ophiopogonis, pueraria lobata, cordate houttuynia are taken, extracting in water 2 times adds in 8~10 times of amount water for the first time, 90 DEG C of temperature~
100 DEG C are kept for 1~2 hour, filtering；Second of addition, 6~8 times of amount water, 90 DEG C~100 DEG C of temperature are kept for 0.5~1 hour, mistake
Filter, merging filtrate；
(2) macroporous absorbent resin on filtrate, respectively with the elution for the first time of 30%~50% ethyl alcohol, 75%~90% ethyl alcohol for the second time
Eluent is collected in elution；
(3) 0.01~0.09Mpa of steam pressure, vacuum degree -0.03~-0.08Mpa, 60~80 DEG C of temperature are concentrated into 50~55
DEG C measure the medicinal extract that relative density is 1.26~1.30；
(4) vacuum degree -0.04~-0.09Mpa, 60~80 DEG C of temperature, dry, pulverize 60 mesh sieve to get.
5. the preparation method of Chinese medicine composition according to claim 4, it is characterised in that：Ethanol eluate in step (2)
Volumetric concentration is respectively：For the first time 35%~45%；Second 80%~90%.
6. the preparation method of Chinese medicine composition according to claim 4, it is characterised in that：Ethanol eluate in step (2)
Volumetric concentration is respectively：For the first time 40%；Second 85%.
7. the preparation method of Chinese medicine composition according to claim 4, it is characterised in that：Steam pressure in step (3)
0.04~0.07Mpa, vacuum degree -0.04~-0.06Mpa, 65~75 DEG C of temperature are concentrated into 50~55 DEG C and measure relative density and be
1.26~1.30 medicinal extract.
8. the preparation method of Chinese medicine composition according to claim 4, it is characterised in that：Steam pressure in step (3)
0.05Mpa, vacuum degree -0.06Mpa, temperature 70 C are concentrated into 55 DEG C and measure the medicinal extract that relative density is 1.26.
9. the preparation method of Chinese medicine composition according to claim 4, it is characterised in that：It is dried in step (4) to aqueous
Measure is 3.5~5.5%.
10. the composition described in claim 1-3 any one claims, with auxiliary material in one or more kinds of pharmacies such as
Starch, dextrin, microcrystalline cellulose, hypromellose, polyethylene glycol, magnesium stearate, superfine silica gel powder, etc. be mixed it is each
Kind dosage form, for example, can be made into tablet, dripping pill, granule, capsule, fine granule.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1788776A (en) * | 2004-12-13 | 2006-06-21 | 河北省中医药研究院高血压糖尿病研究所 | Chinese traditional medicine for treating diabetes retinopathy |
| CN104055963A (en) * | 2013-11-28 | 2014-09-24 | 天津天狮生物发展有限公司 | Fat loss traditional Chinese medicine composition and preparation method thereof |
| CN105616937A (en) * | 2014-10-29 | 2016-06-01 | 陆永达 | Traditional Chinese medicine for treating diabetes |
| KR20170088478A (en) * | 2016-01-22 | 2017-08-02 | 대전대학교 산학협력단 | A composition for antioxidating, antiinflamatory and antidiabetes comprising extracts of inyoolsan |
-
2018
- 2018-03-14 CN CN201810208982.1A patent/CN108186876A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1788776A (en) * | 2004-12-13 | 2006-06-21 | 河北省中医药研究院高血压糖尿病研究所 | Chinese traditional medicine for treating diabetes retinopathy |
| CN104055963A (en) * | 2013-11-28 | 2014-09-24 | 天津天狮生物发展有限公司 | Fat loss traditional Chinese medicine composition and preparation method thereof |
| CN105616937A (en) * | 2014-10-29 | 2016-06-01 | 陆永达 | Traditional Chinese medicine for treating diabetes |
| KR20170088478A (en) * | 2016-01-22 | 2017-08-02 | 대전대학교 산학협력단 | A composition for antioxidating, antiinflamatory and antidiabetes comprising extracts of inyoolsan |
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Application publication date: 20180622 |