CN108175739A - A kind of stem cell composite factor anti-aging cosmetics - Google Patents
A kind of stem cell composite factor anti-aging cosmetics Download PDFInfo
- Publication number
- CN108175739A CN108175739A CN201810052033.9A CN201810052033A CN108175739A CN 108175739 A CN108175739 A CN 108175739A CN 201810052033 A CN201810052033 A CN 201810052033A CN 108175739 A CN108175739 A CN 108175739A
- Authority
- CN
- China
- Prior art keywords
- stem cell
- skin
- factor
- aging cosmetics
- growth factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of stem cell composite factor anti-aging cosmetics, including following component：Glycerine 3%；Hyaluronic acid 0.4%；Preservative M98 0.15%；Albumin 1%；Stem cell culture supernatant 30%；40000/ml of stem cell lysate；Platelet derived growth factor 70ug/ml；Epidermal growth factor 50ug/ml；Glial growth factor 45ug/ml；Insulin-like growth factor 2 5ug/ml；Dextran 5 %；Surplus is ultra-pure water.The present invention reached by the effect of stem cell composite factor efficiently repair, smooth away wrinkles, anti-aging, the function of lightening the stain and moisten moisturizing.
Description
Technical field
The invention belongs to cosmetic technical field more particularly to a kind of stem cell composite factor anti-aging cosmetics.
Background technology
Among modern city, solarization, haze, radiation, color make-up etc. are ubiquitous to the injury of skin, cause various skins
Problem, if skin is intense darkness without light, skin elasticity reduces, color spot, wrinkle, acne etc..Skin is due to quick caused by non-genetic factor
Sense phenomenon is more and more, and demand of the people to protective cosmetics is also just come into being, such as facial treatment milk, toner, foundation cream
Liquid, suncream or sun screen have become one of cosmetics of modern female indispensability.
At present, from the point of view of the ingredient of commercially available all kinds of cosmetics, the effect of most of cosmetics, is still relatively simple, traditional
Cosmetics only the supply of external nutrition and cover ageing skin skin, can not prevent the aging of skin.And one
As method manufacture nutrients and active matter cosmetics actual effect it is little because nutrients and active matter are not easy to penetrate into skin
Deep layer, normal skin can only absorb some small molecules and liposoluble substance, be nonabsorbable to macro-molecular protein, it more difficult into
Enter intracellular, due to easily being influenced by external condition, also tend to early the sixth of the twelve Earthly Branches when in use inactivates active matter, and as cosmetics are got over
It receives and uses come more women, continuing to research and develop the new application of cosmetics becomes the new trend that cosmetics develop.At present, city
On face some cosmetics by adding in silicon compound, mica and light modify particle etc. can be promoted skin smooth texture ingredient and
Pigment particles make adjustment of modification pore that cosmetics have and skin color and other effects, but this method can not solve skin
The problems such as original skin dimness of skin, color spot, wrinkle or aging, long-time service also will further result in skin problem deterioration.
Invention content
It is an object of the invention to overcome above-mentioned the deficiencies in the prior art, provide it is a kind of have efficiently repair, smooth away wrinkles,
Anti-aging and the stem cell composite factor anti-aging cosmetics lightened the stain, it is intended to which solving existing cosmetics cannot fundamentally change
The problems such as original skin dimness of kind skin, color spot, wrinkle or aging or even long-time service also will further result in skin and ask
The phenomenon that topic deteriorates.
The invention is realized in this way a kind of stem cell composite factor anti-aging cosmetics are provided, including following component：
Glycerine 3%；
Hyaluronic acid 0.4%；
Preservative M98 0.15%；
Albumin 1%；
Stem cell culture supernatant 30%；
40000/ml of stem cell lysate；
Platelet derived growth factor 70ug/ml；
Epidermal growth factor 50ug/ml；
Glial growth factor 45ug/ml；
Insulin-like growth factor 2 5ug/ml；
Dextran 5 %；
Surplus is ultra-pure water.
Wherein, the PH values of the preservative M98 are 3-7, and density is 1.02 ~ 1.10（20℃g/cm3）, active matter content
≥9.5% 。
Wherein, the hyaluronic acid is macromolecular hyaluronic acid and micromolecule hyaluronic acid according to weight ratio 13:4 compound
It arrives, wherein, the molecular weight ranges of macromolecular hyaluronic acid are 1 800000~2200000, the molecular weight of micromolecule hyaluronic acid
Ranging from 400000~1000000.
Wherein, the fusing point of the glycerine is 20 DEG C, and the boiling point of the glycerine is 290 DEG C under decomposition condition, the glycerine
Surface tension under the conditions of 20 DEG C for 63.3 mN/m, the saturated vapor of the glycerine be pressed in 20 DEG C under the conditions of for 0.4kPa, institute
The viscosity for stating glycerine is 1412mPa.s under the conditions of 20 DEG C.
Wherein, the receptor of the platelet derived growth factor is tyrosine kinase (RTK) receptor, by two polypeptide chains
The homotype or heterodimer being formed by connecting by disulfide bond.
Wherein, the epidermal growth factor contains 6 half Guangs by 50-60 Amino acid score molecular peptide chain in peptide chain
Propylhomoserin molecule forms stable cystine linkage between half Guang amino molecule.
Wherein, the relative molecular mass of the glial growth factor is 31000, and molecular structure includes 1 segment signal
Peptide, 1 section of kringle samples sequence, 1 immunoglobulin spline structure, 1 epidermal growth factor-like structure.
Wherein, a kind of macromolecule Portugal that dextran system sucrose generates after leuconostoc mesenteroide -1226 is fermented
Grape glycopolymers are obtained through handling refined.
Wherein, the stem cell composite factor anti-aging cosmetics are solution, suspension, emulsion, creme, paste, coagulate
Glue, milk, shin moisturizer, powder, perfumed soap, oil, dry powder, foundation emulsion, wet-milling or spray.
In conclusion by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
1. stem cell composite factor anti-aging cosmetics of the present invention reach efficient repairing by the effect of stem cell composite factor
Multiple function, specific receptor of each growth factor actively near the wound on cell membrane are combined, so as to activator protein enzyme, accelerate
The synthesis of protein promotes fibroblastic growth, promotes skin and mucous membrane wound healing and supports scar contraction and skin
Lopsided hyperplasia, rapidly and efficiently repair wound.Applied to the various damages of skin histology, removal dark sore, acne, go it is small after mole
Defect changes the tools such as caused skin burn, epidermis injury reparation after grinding after the uses such as peeling after skin, rubescent and tartaric acid
There is prominent effect.Stem cell composite factor can promote epidermal cell proliferation to break up, and the cell of aging death is enable to mend in time
It fills, the epidermis of damage is enable to repair immediately, available for the tune exchanged skin, take off the various bad skin quality such as red, telangiectasis
It is whole, improve the undesirable conditions such as thin, the coarse, scar of skin, skin is made to restore bright and clean and smooth.
2. stem cell composite factor anti-aging cosmetics of the present invention, are reached by the effect of stem cell composite factor and disappeared
Wrinkle function, can promote fibroblast, epidermal cell metabolism, proliferation and growth, promote elastomer cell development and
Enhance its function, activate the regeneration of aged cells, accelerate the metabolism and update of cell, tachymetabolism aging cutin is repaired
The shallow dermal fibroblasts of fracture, so as to smooth away wrinkles.Promote the proliferation of fibroblast in skin corium by active factors,
Repair the collagenous fibres and elastomer of aging；It more synthesizes and secretes the macromoleculars such as collagen, hyaluronic acid；Improve skin
Skin microcirculation provides good nutrient environment, maintains a certain amount of skin fat, restores elasticity of skin, it is made uniformly to compact, is subtracted
Few wrinkle.
3. stem cell composite factor anti-aging cosmetics of the present invention reach anti-by the effect of stem cell composite factor
Aging function can promote growth, the division of the various kinds of cell such as epidermal tissue's epithelial cell, horn cell, fibroblast, accelerate
Metabolism enhances its epidermal cell activity, so as to which cell be made to keep the perfect of quality and quantity, wrinkle of skin is made to disappear, is shown
Consolidation, tender, bright and clean and flexible health are beautiful.Promote cell metabolism（Anti-aging）：It can promote the increasing of cell
It grows, break up.It can make mature cell is inverse to be differentiated to form " stem cell island ", while contain the expression of aging gene.Fundamentally change
Become Skin Cell to form, reduce Skin Cell average age, enable skin bright and clean beautiful.
4. stem cell composite factor anti-aging cosmetics of the present invention reach light by the effect of stem cell composite factor
Change color spot function, to more black skin and all kinds of cutaneous pigmentations, this cosmetics can be replaced by promoting neonatal cell
For senile cell, to reduce the content of melanin and coloured corpuscle in skin；And skin blood flow can be increased, it is micro- to improve skin
Cycle, provides good nutrient environment for epidermal cell, prevents metabolite from depositing, be effectively improved skin colour, make more black skin
Color and all kinds of pigmented whitening skins are perfect, uniformly beautiful.To compared with casting skin and all kinds of cutaneous pigmentations, accelerating cell
Hyperplasia promotes the distribution of subcutaneous capillary net, promotes blood circulation, dermal melanin is made to accelerate discharge, effectively reduces melanin
Deposition, play the role of Whitening, spot.
5. stem cell composite factor anti-aging cosmetics of the present invention reach taste by the effect of stem cell composite factor
Moisten water supplement function, skin microcirculation can be improved（It is bright and clean）, promote hyaluronic acid synthesis and secretion（It moistens）：Composite factor can promote
The synthesis and secretion of the macromoleculars such as extracellular hyaluronic acid, glycoprotein enhance the hydrophily of skin, keep moisture in skin.This
Cosmetics can improve skin microcirculation, enable qi and blood unobstructed, prevent metabolite from depositing, and make skin being rich in nutrition.Maintain intradermal
Moisture；Skin is got well, and the enhancing of epidermis endocuticle water holding capacity allows skin to moisten the vigor of distributing.Composite factor
Skin microcirculation can be improved, good nutrient environment is provided, maintain a certain amount of skin fat, elasticity of skin is restored, make it
It uniformly compacts, reduces wrinkle.
Specific embodiment
The technical solution in the embodiment of the present invention is clearly and completely described below.
The embodiment of the present invention provides a kind of stem cell composite factor anti-aging cosmetics, including following component：
Glycerine 3%；
Hyaluronic acid 0.4%；
Preservative M98 0.15%；
Albumin 1%；
Stem cell culture supernatant 30%；
40000/ml of stem cell lysate；
Platelet derived growth factor 70ug/ml；
Epidermal growth factor 50ug/ml；
Glial growth factor 45ug/ml；
Insulin-like growth factor 2 5ug/ml；
Dextran 5 %；
Surplus is ultra-pure water.
Further, the fusing point of the glycerine is 20 DEG C, and the boiling point of the glycerine is 290 DEG C under decomposition condition, described
The surface tension of glycerine under the conditions of 20 DEG C for 63.3 mN/m, the saturated vapor of the glycerine be pressed in 20 DEG C under the conditions of be
0.4kPa, the viscosity of the glycerine is 1412mPa.s under the conditions of 20 DEG C
Glycerine in the embodiment of the present invention, appearance colorless clear viscous liquid, it is no it is ugly, tasteless, have hygroscopicity, humectation,
The property of softening, the extremely aobvious moisture absorbed in air, water solubility are in neutrality, and have good freeze-proof.
Hyaluronic acid also known as sodium hyaluronate in the embodiment of the present invention are a kind of acid mucopolysaccharides.It is the tender weight of skin water
Basic substance is wanted, itself is also a kind of ingredient of human body, it has special water retention, and deal is more up to itself weight
100 times, be the substance that moisture retention is best in presently found nature, is referred to as ideal natural moisturizing factor.It can change
Kind skin-nourishing metabolism, make skin it is tender, it is smooth, go to wrinkle, increase it is elastic, prevent aging, be good again while moisturizing
Skin penetration enhancer.It is used cooperatively with other nutritional ingredients, the more preferable effect for promoting nutrient absorption can be played.
Further, the hyaluronic acid is macromolecular hyaluronic acid and micromolecule hyaluronic acid according to weight ratio 13:4 is multiple
With obtaining, wherein, the molecular weight ranges of macromolecular hyaluronic acid are 1 800000~2200000, point of micromolecule hyaluronic acid
Son amount ranging from 400000~1000000.
Further, the PH values of the preservative M98 are 3-7, and density is 1.02 ~ 1.10（20℃g/cm3）, active matter
Content >=9.5%
Preservative M98 in the embodiment of the present invention, appearance colorless or yellowish transparency liquid, with water, low content alcohol and second
Glycol is miscible, meanwhile, have compatible including surfactant, ZPT and ultra-violet absorber with various personal care articles raw materials
Unique performance.
Further, the albumin (also known as albumin, albumin, Alb), is dissolved in water and meets a thermoset bulb
Shape simple proteins are synthesized by hepatic parenchymal cells, and the half life in blood plasma is about 15-19 days, are that content is most in blood plasma
Protein accounts for the 40%-60% of Total plasma protein.Although its synthetic ratio in by food protein content influenced, mainly by blood
Level tune in slurry almost without storage in liver cell, all contains micro albumin in all extracellular fluids.About white
Filtration situation of the albumen in glomerulus, it is considered that its amount is little under normal circumstances, albumin about in blood plasma
0.04%, the albumin discharged from glomerular filtrate daily by this calculating is i.e. up to 3.6g, for protein output in urine eventually
30-40 times, it is seen that most albumin can be reuptaked by renal tubule in filtered solution.There is experiment to confirm albumin near bent
It is absorbed in tubule, blood circulation is entered for small molecule segment by the hydrolase in lysosome in tubule cells.Albumin
It can be absorbed in different tissues by cell endocytic, amino acid can be used as tissue repairing.
Stem cell (stem cells, SC) in the embodiment of the present invention is a kind of with the of self-replication capacity (self-
Renewing multipotential cell), under certain condition, it can be divided into multiple functions cell.According to residing for stem cell
Stage of development is divided into embryonic stem cell (embryonic stem cell, ES cell) and adult stem cell (somatic stem
cell).It is divided into three classes according to the potentiality of development of stem cell:Myeloid-lymphoid stem cell (totipotent stem cell, TSC), multipotency
Stem cell (pluripotent stem cell) and unipotent stem cell (unipotent stem cell).Stem cell (Stem
Cell it is) a kind of inabundant differentiation, still immature cell has the potential function for regenerating various histoorgans and human body, doctor
Educational circles is known as " general-purpose cell ".Stem cell culture supernatant and stem cell lysate are needed in the incubation for act on stem cell
The specific culture environment wanted has reached the adherent or value-added effect of stem cell.Stem cell serum-free culture medium is serum-free, is free of
The human stem cells culture medium of heterologous animal ingredient (Xeno-free), can promote the growth of the human stem cells in a variety of sources, such as
Marrow (BM-hMSC), umbilical cord (UCM-hMSC).Stem cell media can promote the long term growth of human stem cells, while can also
Keep multi-lineage potential.Stem cell media and stem cell serum-free nutritional supplements are used in conjunction with, and cell is adherent and rises in value
Effect is more preferable.
Further, the platelet derived growth factor (Platelet derived growth factor, PDGF)
Receptor is tyrosine kinase (RTK) receptor, the homotype being formed by connecting by two polypeptide chains by disulfide bond or Heterodimeric
Body.The platelet derived growth factor can promote impaired skin deep layer cells organization healing, reach increase moisture of skin, crease-resistant,
The effect of red blood silk is gone in antiallergic sense.
Further, the epidermal growth factor（Epidermal growth factor, EGF）It is the life found earliest
The long factor exchanges ganglion cell's growth, proliferation and differentiation and plays an important role, by the molecular peptide of 50-60 Amino acid score
Containing 6 cysteine molecules in peptide chain, stable cystine linkage is formed between half Guang amino molecule for chain.The epidermal growth factor can
Promote the growth division of various kinds of cell in epidermal cell tissue, promote collagen synthesis, repair the collagen elasticity of aging fracture
Fiber reaches skin exquisiteness, and blackspot after hair pore shrinkage desalination is shone increases skin elasticity, goes the effect of the anti-acne anti-acne of scar, and table
The skin care of skin growth factor is good for skin effect and depends on its unique bioactivity, to make full use of its physiological property, make
It plays a role to greatest extent during skin metabolism, on the one hand to protect its fully activity, on the other hand also
Protect the abundant moisture of skin.
Epidermal growth factor EGF in the embodiment of the present invention by and the combinations of EGF receptor high-affinities irritate table
Chrotoplast（Epithelial cell including Various Tissues source, various interstitial cells）Into cell division cycle, one in active cell
A little critical function gene activations, expression, secretion biological activity protein etc..Promote the linear arrangement of collagenous fibres, epidermal cell
Fast regular is grown and timely flap coverage, starts the process of wound repair, hence it is evident that accelerates after beauty, cosmetic operation and other skins
The wound healings such as wound, and surface of a wound flat smooth is kept, reduce abnormal pigmentary deposit on the skin trace and pigmentation.Modern study discovery, epidermal growth factor
Son can irritate various cells such as corneal epithelium and endothelial cell, epidermis, the corium confluent monolayer cells of ectoderm and endodermal origin（Such as fibre
Tie up mother cell）, mammary gland alveolus and interstitial cell etc., make its proliferation apoptosis, accelerate metabolism, achieve the effect that tender skin.Simultaneously
It can promote the biosynthesis of various protein, promote the synthesis of extracellular macromolecular（Such as hyaluronic acid, elastomer albumen）,
Increase moisture content of skin, and then increase skin elasticity, moisturizing.Cytotrophy substance is promoted actively to be transported to cell from extracellular
It is interior, increase intracellular nutrition, promote the functional moleculars such as corium confluent monolayer cells secretion synthesis collagenous fibres, polysaccharide, glycoprotein, make
Subcutaneous dermal tissue is full, muscle fibre marshalling is close, so as to reduce and smooth away wrinkles.Have to the proliferation of epidermal cell relatively strong
Facilitation, make youthening of epidermal cell so that less residual for having pigment and dead cell etc. is tired in epidermal tissue
Product, make cutaneous manifestations go out it is tender have no time in vain, eliminate the abnormal skins such as color spot and pigmentation and show, can effectively contain answering for color spot
Hair.
Further, the glial growth factor（KGF）Relative molecular mass for 31000, molecular structure packet
Include 1 segment signal peptide, 1 section of kringle samples sequence, 1 immunoglobulin spline structure, 1 epidermal growth factor-like structure, the glue
Cell plastid growth factor can promote the metabolism of corneocyte, maintain the thickness of cuticula, promote smegma, reach
Eliminate coarse, skin becomes bright and clean effect.
Further, the insulin-like growth factor (insulin-like growth factor, IGF) is a kind of
The multi-functional regulation of cell proliferation factor, the differentiation of cell, proliferation, individual growth and development in have important facilitation.
What is had now found that includes IGF-1 and two kinds of IGF-2, and the insulin-like growth factor can promote cell division, reach scar
The effect of acne print.
Further, a kind of high score that dextran system sucrose generates after leuconostoc mesenteroide -1226 is fermented
Sub- glucose polymer is obtained through handling refined.
Further, the stem cell composite factor anti-aging cosmetics are solution, suspension, emulsion, creme, cream
Shape, gel, milk, shin moisturizer, powder, perfumed soap, oil, dry powder, foundation emulsion, wet-milling or spray.
In conclusion by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
1. stem cell composite factor anti-aging cosmetics of the present invention reach efficient repairing by the effect of stem cell composite factor
Multiple function, specific receptor of each growth factor actively near the wound on cell membrane are combined, so as to activator protein enzyme, accelerate
The synthesis of protein promotes fibroblastic growth, promotes skin and mucous membrane wound healing and supports scar contraction and skin
Lopsided hyperplasia, rapidly and efficiently repair wound.Applied to the various damages of skin histology, removal dark sore, acne, go it is small after mole
Defect changes the tools such as caused skin burn, epidermis injury reparation after grinding after the uses such as peeling after skin, rubescent and tartaric acid
There is prominent effect.Stem cell composite factor can promote epidermal cell proliferation to break up, and the cell of aging death is enable to mend in time
It fills, the epidermis of damage is enable to repair immediately, available for the tune exchanged skin, take off the various bad skin quality such as red, telangiectasis
It is whole, improve the undesirable conditions such as thin, the coarse, scar of skin, skin is made to restore bright and clean and smooth.
2. stem cell composite factor anti-aging cosmetics of the present invention, are reached by the effect of stem cell composite factor and disappeared
Wrinkle function, can promote fibroblast, epidermal cell metabolism, proliferation and growth, promote elastomer cell development and
Enhance its function, activate the regeneration of aged cells, accelerate the metabolism and update of cell, tachymetabolism aging cutin is repaired
The shallow dermal fibroblasts of fracture, so as to smooth away wrinkles.Promote the proliferation of fibroblast in skin corium by active factors,
Repair the collagenous fibres and elastomer of aging；It more synthesizes and secretes the macromoleculars such as collagen, hyaluronic acid；Improve skin
Skin microcirculation provides good nutrient environment, maintains a certain amount of skin fat, restores elasticity of skin, it is made uniformly to compact, is subtracted
Few wrinkle.
3. stem cell composite factor anti-aging cosmetics of the present invention reach anti-by the effect of stem cell composite factor
Aging function can promote growth, the division of the various kinds of cell such as epidermal tissue's epithelial cell, horn cell, fibroblast, accelerate
Metabolism enhances its epidermal cell activity, so as to which cell be made to keep the perfect of quality and quantity, wrinkle of skin is made to disappear, is shown
Consolidation, tender, bright and clean and flexible health are beautiful.Promote cell metabolism（Anti-aging）：It can promote the increasing of cell
It grows, break up.It can make mature cell is inverse to be differentiated to form " stem cell island ", while contain the expression of aging gene.Fundamentally change
Become Skin Cell to form, reduce Skin Cell average age, enable skin bright and clean beautiful.
4. stem cell composite factor anti-aging cosmetics of the present invention reach light by the effect of stem cell composite factor
Change color spot function, to more black skin and all kinds of cutaneous pigmentations, this cosmetics can be replaced by promoting neonatal cell
For senile cell, to reduce the content of melanin and coloured corpuscle in skin；And skin blood flow can be increased, it is micro- to improve skin
Cycle, provides good nutrient environment for epidermal cell, prevents metabolite from depositing, be effectively improved skin colour, make more black skin
Color and all kinds of pigmented whitening skins are perfect, uniformly beautiful.To compared with casting skin and all kinds of cutaneous pigmentations, accelerating cell
Hyperplasia promotes the distribution of subcutaneous capillary net, promotes blood circulation, dermal melanin is made to accelerate discharge, effectively reduces melanin
Deposition, play the role of Whitening, spot.
5. stem cell composite factor anti-aging cosmetics of the present invention reach taste by the effect of stem cell composite factor
Moisten water supplement function, skin microcirculation can be improved（It is bright and clean）, promote hyaluronic acid synthesis and secretion（It moistens）：Composite factor can promote
The synthesis and secretion of the macromoleculars such as extracellular hyaluronic acid, glycoprotein enhance the hydrophily of skin, keep moisture in skin.This
Cosmetics can improve skin microcirculation, enable qi and blood unobstructed, prevent metabolite from depositing, and make skin being rich in nutrition.Maintain intradermal
Moisture；Skin is got well, and the enhancing of epidermis endocuticle water holding capacity allows skin to moisten the vigor of distributing.Composite factor
Skin microcirculation can be improved, good nutrient environment is provided, maintain a certain amount of skin fat, elasticity of skin is restored, make it
It uniformly compacts, reduces wrinkle.
The above is the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also considered as
Protection scope of the present invention.
Claims (9)
1. a kind of stem cell composite factor anti-aging cosmetics, which is characterized in that including following component：
Glycerine 3%；
Hyaluronic acid 0.4%；
Preservative M98 0.15%；
Albumin 1%；
Stem cell culture supernatant 30%；
40000/ml of stem cell lysate；
Platelet derived growth factor 70ug/ml；
Epidermal growth factor 50ug/ml；
Glial growth factor 45ug/ml；
Insulin-like growth factor 2 5ug/ml；
Dextran 5 %；
Surplus is ultra-pure water.
2. stem cell composite factor anti-aging cosmetics as described in claim 1, which is characterized in that the preservative M98's
PH values are 3-7, and density is 1.02 ~ 1.10（20℃g/cm3）, active matter content >=9.5%.
3. stem cell composite factor anti-aging cosmetics as described in claim 1, which is characterized in that the hyaluronic acid is big
Molecular weight hyaluronic acid and micromolecule hyaluronic acid are according to weight ratio 13:4 compoundings obtain, wherein, the molecule of macromolecular hyaluronic acid
Amount ranging from 1 800000~2200000, the molecular weight ranges of micromolecule hyaluronic acid are 400000~1000000.
4. stem cell composite factor anti-aging cosmetics as described in claim 1, which is characterized in that the fusing point of the glycerine is
20 DEG C, the boiling point of the glycerine is 290 DEG C under decomposition condition, and the surface tension of the glycerine is 63.3 under the conditions of 20 DEG C
MN/m, the saturated vapor of the glycerine be pressed in 20 DEG C under the conditions of for 0.4kPa, the viscosity of the glycerine be under the conditions of 20 DEG C
1412mPa.s。
5. stem cell composite factor anti-aging cosmetics as described in claim 1, which is characterized in that the platelet derived growth
The receptor of the factor is tyrosine kinase (RTK) receptor, the homotype being formed by connecting by two polypeptide chains by disulfide bond or different
Type dimer.
6. stem cell composite factor anti-aging cosmetics as described in claim 1, which is characterized in that the epidermal growth factor
By the molecular peptide chain of 50-60 Amino acid score, 6 cysteine molecules are contained in peptide chain, is formed and stablized between half Guang amino molecule
Cystine linkage.
7. stem cell composite factor anti-aging cosmetics as described in claim 1, which is characterized in that the glial growth
The relative molecular mass of the factor is 31000, and molecular structure includes 1 segment signal peptide, 1 section of kringle samples sequence, 1 immune ball
Proteinaceous structures, 1 epidermal growth factor-like structure.
8. stem cell composite factor anti-aging cosmetics as described in claim 1, which is characterized in that dextran system sugarcane
A kind of macromolecule glucose polymer that sugar generates after leuconostoc mesenteroide -1226 is fermented is obtained through handling refined.
9. such as claim 1-8 any one of them stem cell composite factor anti-aging cosmetics, which is characterized in that described dry thin
Born of the same parents' composite factor anti-aging cosmetics are solution, suspension, emulsion, creme, paste, gel, milk, shin moisturizer, powder, perfume (or spice)
Soap, oil, dry powder, foundation emulsion, wet-milling or spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810052033.9A CN108175739A (en) | 2018-01-19 | 2018-01-19 | A kind of stem cell composite factor anti-aging cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810052033.9A CN108175739A (en) | 2018-01-19 | 2018-01-19 | A kind of stem cell composite factor anti-aging cosmetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108175739A true CN108175739A (en) | 2018-06-19 |
Family
ID=62551032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810052033.9A Pending CN108175739A (en) | 2018-01-19 | 2018-01-19 | A kind of stem cell composite factor anti-aging cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108175739A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109700681A (en) * | 2019-02-27 | 2019-05-03 | 邹红媚 | A kind of preparation method and application of composite factor facial mask |
| CN111494298A (en) * | 2020-04-30 | 2020-08-07 | 成都容医汇生物技术研究院 | Efficient skin repair protective agent and preparation method thereof |
| CN112245653A (en) * | 2020-11-13 | 2021-01-22 | 杭州伊瑟奇生物科技有限公司 | Protein film dressing assisting wound healing based on cooperation of three bioactive scaffold materials and cell trophic factors |
-
2018
- 2018-01-19 CN CN201810052033.9A patent/CN108175739A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109700681A (en) * | 2019-02-27 | 2019-05-03 | 邹红媚 | A kind of preparation method and application of composite factor facial mask |
| CN111494298A (en) * | 2020-04-30 | 2020-08-07 | 成都容医汇生物技术研究院 | Efficient skin repair protective agent and preparation method thereof |
| CN112245653A (en) * | 2020-11-13 | 2021-01-22 | 杭州伊瑟奇生物科技有限公司 | Protein film dressing assisting wound healing based on cooperation of three bioactive scaffold materials and cell trophic factors |
| CN112245653B (en) * | 2020-11-13 | 2022-07-01 | 杭州伊瑟奇生物科技有限公司 | Protein film dressing assisting wound healing based on cooperation of three bioactive scaffold materials and cell trophic factors |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105125476B (en) | A kind of anti-wrinkle essence and preparation method thereof | |
| CN108186548A (en) | A kind of preparation method of the stem cell factor Essence with anti-aging effects | |
| CN110339147A (en) | A kind of composition for external application and application thereof | |
| CN108175739A (en) | A kind of stem cell composite factor anti-aging cosmetics | |
| CN110496067A (en) | A kind of anti-wrinkle composition and its preparation method and application | |
| CN107496310A (en) | A kind of facial treatment essence liquid and preparation method thereof | |
| CN101785852A (en) | Dermis trace intervention anti-wrinkle cosmetic preparation and method | |
| CN104042545A (en) | Age-reducing skin care product aiming at cell gene regeneration and repair | |
| CN109730953A (en) | A kind of hyaluronic acid (sodium hyaluronate) stoste and preparation method thereof | |
| CN105193671A (en) | Nourishing skin care lotion and preparation method thereof | |
| CN1872025A (en) | Production for skin beautification and care, and preparation method | |
| CN109381408A (en) | A kind of anti-ageing Essence of moisturizing and preparation method thereof | |
| CN108721137A (en) | A kind of freeze-dried powder for repairing skin | |
| CN103479567A (en) | Epidermal growth factor complex lipidosome, and preparation method and application of lipidosome | |
| CN103948536A (en) | Ant essence-placenta low-molecular active polypeptide composite anti-aging skin-care composition | |
| CN110151621A (en) | Soothing and repairing face mask and preparation method thereof | |
| CN116987151B (en) | Preparation method and application of umbilical cord mesenchymal stem cell supernatant in skin repair and anti-aging composition | |
| CN106176561A (en) | A kind of autologous skin fibroblast is for the preparation method of beautifying and antisenility | |
| CN103705431A (en) | Fish source collagen antioxidant peptide beauty mask and preparation method thereof | |
| CN108434087A (en) | A kind of cosmetics comprising stem cell extract and aloe small active peptides | |
| KR20100096447A (en) | Cosmetic composition comprising matrials cultured adult stem cells derived from swine placenta tissue and proteins extracted therefrom | |
| CN108309919A (en) | Goat Placenta-peptide-bone collagen peptide composition, the facial mask liquid containing the composition | |
| CN104323966A (en) | Golden hydrotherapy composition and using method thereof | |
| CN108125903A (en) | A kind of novel stem cells composite factor anti-aging cosmetics | |
| CN108096113B (en) | Sheep placenta peptide composition and facial mask liquid containing same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180619 |