CN108159428A - A kind of Thermosensitive Material Used for Controlled Releasing of Medicine and preparation method thereof - Google Patents
A kind of Thermosensitive Material Used for Controlled Releasing of Medicine and preparation method thereof Download PDFInfo
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- CN108159428A CN108159428A CN201810033600.6A CN201810033600A CN108159428A CN 108159428 A CN108159428 A CN 108159428A CN 201810033600 A CN201810033600 A CN 201810033600A CN 108159428 A CN108159428 A CN 108159428A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a kind of Thermosensitive Material Used for Controlled Releasing of Medicine and preparation method thereof.Preparation method is as follows：（1）Low-molecular weight chitoglycan, polyanion cellulose, silk peptide, polycaprolactone, bovine serum albumin, glycolic, aloe polysaccharide and deionized water are mixed, obtain component A；（2）By garlic oil, N, the bis- oleoyl ethylenediamine diethyl sodium sulfonates of N' and polyethylene glycol are mixed, and obtain component B；（3）Component A and B are mixed, ultrasonic shear；（4）Add in sodium tripolyphosphate and glutaraldehyde, heating stirring；（5）Water phase is obtained after standing separation, adjusts pH value to 8, low-speed centrifugal removes larger particle；（6）Suspension pH value is adjusted to neutrality, centrifugation discards solvent, is drying to obtain.The Thermosensitive Material Used for Controlled Releasing of Medicine of the present invention has higher water absorption rate, and hydrophily is good, and envelop rate is high, while has good sustained drug release effect, the most suitable for 1/drug for 24 hours.
Description
Technical field
The present invention relates to biomedical materials fields, and in particular to a kind of Thermosensitive Material Used for Controlled Releasing of Medicine and preparation method thereof.
Background technology
It is administered by traditional approach, most drugs ingredient discharges quickly, causes the rapid raising of internal levels of drugs, reaches
It is reduced rapidly after to peak value.And for drug, effect is closely related with the concentration of drug in blood serum, and violent fluctuation is past
Unacceptable side effect is generated in peak value toward causing, insufficient control then is caused since the concentration of drug in blood serum is too low
Therapeutic effect.In order to maintain internal necessary drug concentration, regular medicine taking or injection for several times on the one can only be used, even if with medicament
It is arranged on amount and administration time interval, internal blood concentration is still within fluctuation status.And controlled release drug delivery system
It comes across in the 1970s, being one kind in drug delivery system, it can be such that drug is discharged with a kind of scheduled rate, make
Drug concentration in blood or tissue is maintained in a long time in the range of effective therapeutic index, extends drug in medicine-feeding part
Residence time, improve bioavilability, achieve the effect that slow-release controlled-release.Relative to traditional administering mode, drug control is released
Place system have can adjust drug releasing rate, reduce administration number of times, generate appropriateness reaction, improve curative effect of medication, reduce medicine
Object toxic side effect, the pain for mitigating patient's medication, it is important so as to increase the safety of drug therapy, high efficiency and reliability etc.
Meaning.
Invention content
Technical problems to be solved：The object of the present invention is to provide a kind of Thermosensitive Material Used for Controlled Releasing of Medicine, have higher water absorption rate,
Hydrophily is good, and envelop rate is high, while has good sustained drug release effect, the most suitable for 1/drug for 24 hours.
Technical solution：A kind of Thermosensitive Material Used for Controlled Releasing of Medicine is prepared by following component with parts by weight：0.5-1.5 parts of silk peptide,
1-2 parts of polycaprolactone, 1-3 parts of bovine serum albumin, 1-2 parts of glycolic, 2-4 parts of garlic oil, 0.5-1 parts of sodium tripolyphosphate, aloe
1-2 parts of polysaccharide, 3-6 parts of low-molecular weight chitoglycan, 2-3 parts of polyanion cellulose, bis- two ethanesulfonic acids of oleoyl ethylenediamine of N, N'-
1-3 parts of sodium, 5-7 parts of polyethylene glycol, 2-4 parts of glutaraldehyde, 50-70 parts of deionized water.
It is further preferred that a kind of Thermosensitive Material Used for Controlled Releasing of Medicine, is prepared by following component with parts by weight：1 part of silk peptide,
1.5 parts of polycaprolactone, 2 parts of bovine serum albumin, 1.5 parts of glycolic, 3 parts of garlic oil, 0.8 part of sodium tripolyphosphate, aloe polysaccharide 1.5
Part, 4.5 parts of low-molecular weight chitoglycan, 2.5 parts of polyanion cellulose, 2 parts of the bis- oleoyl ethylenediamine diethyl sodium sulfonates of N, N'-,
6 parts of polyethylene glycol, 3 parts of glutaraldehyde, 60 parts of deionized water.
Further, the weight average molecular weight of the low-molecular weight chitoglycan is 4.8 × 104, deacetylation 92%.
The preparation method of said medicine slow-release material includes the following steps：
(1) by low-molecular weight chitoglycan, polyanion cellulose, silk peptide, polycaprolactone, bovine serum albumin, glycolic, aloe
20-30min is mixed in polysaccharide and deionized water, obtains component A；
(2) 10-20min is mixed in garlic oil, N, the bis- oleoyl ethylenediamine diethyl sodium sulfonates of N'- and polyethylene glycol, obtains group
Divide B；
(3) component A and B are mixed, ultrasonic shear 5-10min；
(4) sodium tripolyphosphate and glutaraldehyde are added in, is heated to 40-50 DEG C of stirring 5-6h；
(5) water phase is obtained after standing separation, adjusts pH value to 8, low-speed centrifugal removes larger particle；
(6) suspension pH value is adjusted to neutrality, is centrifuged 3-5min under rotating speed 2500-3000r/min, is discarded solvent, drying is
.
Further, 45 DEG C are heated in the step (4), mixing time 5.5h.
Further, rotating speed is 2800r/min, centrifugation time 4min in the step (6).
Advantageous effect：The Thermosensitive Material Used for Controlled Releasing of Medicine of the present invention has higher water absorption rate, reaches as high as 44.4%, and hydrophily is good, packet
Envelope rate is high, reaches as high as 94.1%, and drug release rate is only in minimum only 26.2%, the 8h of drug release rate in 2h
Drug release rate is 79.6% in 57.4%, 16h, and interior drug release is basically completed for 24 hours, has good sustained drug release effect,
It is suitable for 1/drug for 24 hours the most.
Specific embodiment
Embodiment 1
A kind of Thermosensitive Material Used for Controlled Releasing of Medicine is prepared by following component with parts by weight：0.5 part of silk peptide, 1 part of polycaprolactone, ox blood
1 part of albumin, 1 part of glycolic, 2 parts of garlic oil, 0.5 part of sodium tripolyphosphate, 1 part of aloe polysaccharide, 3 parts of low-molecular weight chitoglycan,
2 parts of polyanion cellulose, 1 part of the bis- oleoyl ethylenediamine diethyl sodium sulfonates of N, N'-, 5 parts of polyethylene glycol, 2 parts of glutaraldehyde, go from
Sub- 50 parts of water.
The preparation method of said medicine slow-release material is：
(1) by low-molecular weight chitoglycan, polyanion cellulose, silk peptide, polycaprolactone, bovine serum albumin, glycolic, aloe
20min is mixed in polysaccharide and deionized water, obtains component A；
(2) 10min is mixed in garlic oil, N, the bis- oleoyl ethylenediamine diethyl sodium sulfonates of N'- and polyethylene glycol, obtains component B；
(3) component A and B are mixed, ultrasonic shear 5min；
(4) sodium tripolyphosphate and glutaraldehyde are added in, is heated to 40 DEG C of stirring 5h；
(5) water phase is obtained after standing separation, adjusts pH value to 8, low-speed centrifugal removes larger particle；
(6) suspension pH value is adjusted to neutrality, is centrifuged 3min under rotating speed 2500r/min, is discarded solvent, is drying to obtain.
Embodiment 2
A kind of Thermosensitive Material Used for Controlled Releasing of Medicine is prepared by following component with parts by weight：0.8 part of silk peptide, 1.5 parts of polycaprolactone, ox
1.5 parts of haemocyanin, 1.5 parts of glycolic, 2.5 parts of garlic oil, 0.7 part of sodium tripolyphosphate, 1.5 parts of aloe polysaccharide, low molecular weight
4 parts of chitosan, 2.5 parts of polyanion cellulose, 2 parts of the bis- oleoyl ethylenediamine diethyl sodium sulfonates of N, N'-, 6 parts of polyethylene glycol, penta
2.5 parts of dialdehyde, 55 parts of deionized water.
The preparation method of said medicine slow-release material is：
(1) by low-molecular weight chitoglycan, polyanion cellulose, silk peptide, polycaprolactone, bovine serum albumin, glycolic, aloe
25min is mixed in polysaccharide and deionized water, obtains component A；
(2) 15min is mixed in garlic oil, N, the bis- oleoyl ethylenediamine diethyl sodium sulfonates of N'- and polyethylene glycol, obtains component B；
(3) component A and B are mixed, ultrasonic shear 7min；
(4) sodium tripolyphosphate and glutaraldehyde are added in, is heated to 45 DEG C of stirring 5.5h；
(5) water phase is obtained after standing separation, adjusts pH value to 8, low-speed centrifugal removes larger particle；
(6) suspension pH value is adjusted to neutrality, is centrifuged 4min under rotating speed 2700r/min, is discarded solvent, is drying to obtain.
Embodiment 3
A kind of Thermosensitive Material Used for Controlled Releasing of Medicine is prepared by following component with parts by weight：1 part of silk peptide, 1.5 parts of polycaprolactone, ox blood
2 parts of albumin, 1.5 parts of glycolic, 3 parts of garlic oil, 0.8 part of sodium tripolyphosphate, 1.5 parts of aloe polysaccharide, low-molecular weight chitoglycan
4.5 parts, 2.5 parts of polyanion cellulose, 2 parts of the bis- oleoyl ethylenediamine diethyl sodium sulfonates of N, N'-, 6 parts of polyethylene glycol, glutaraldehyde
3 parts, 60 parts of deionized water.
The preparation method of said medicine slow-release material is：
(1) by low-molecular weight chitoglycan, polyanion cellulose, silk peptide, polycaprolactone, bovine serum albumin, glycolic, aloe
25min is mixed in polysaccharide and deionized water, obtains component A；
(2) 15min is mixed in garlic oil, N, the bis- oleoyl ethylenediamine diethyl sodium sulfonates of N'- and polyethylene glycol, obtains component B；
(3) component A and B are mixed, ultrasonic shear 8min；
(4) sodium tripolyphosphate and glutaraldehyde are added in, is heated to 45 DEG C of stirring 5.5h；
(5) water phase is obtained after standing separation, adjusts pH value to 8, low-speed centrifugal removes larger particle；
(6) suspension pH value is adjusted to neutrality, is centrifuged 4min under rotating speed 2800r/min, is discarded solvent, is drying to obtain.
Embodiment 4
A kind of Thermosensitive Material Used for Controlled Releasing of Medicine is prepared by following component with parts by weight：1.5 parts of silk peptide, 2 parts of polycaprolactone, ox blood
3 parts of albumin, 4 parts of garlic oil, 1 part of sodium tripolyphosphate, 2 parts of aloe polysaccharide, 6 parts of low-molecular weight chitoglycan, gathers 2 parts of glycolic
3 parts of anionic cellulose, 3 parts of the bis- oleoyl ethylenediamine diethyl sodium sulfonates of N, N'-, 7 parts of polyethylene glycol, 4 parts of glutaraldehyde, deionization
70 parts of water.
The preparation method of said medicine slow-release material is：
(1) by low-molecular weight chitoglycan, polyanion cellulose, silk peptide, polycaprolactone, bovine serum albumin, glycolic, aloe
30min is mixed in polysaccharide and deionized water, obtains component A；
(2) 20min is mixed in garlic oil, N, the bis- oleoyl ethylenediamine diethyl sodium sulfonates of N'- and polyethylene glycol, obtains component B；
(3) component A and B are mixed, ultrasonic shear 10min；
(4) sodium tripolyphosphate and glutaraldehyde are added in, is heated to 50 DEG C of stirring 6h；
(5) water phase is obtained after standing separation, adjusts pH value to 8, low-speed centrifugal removes larger particle；
(6) suspension pH value is adjusted to neutrality, is centrifuged 5min under rotating speed 3000r/min, is discarded solvent, is drying to obtain.
Comparative example 1
Difference lies in do not contain silk peptide and bovine serum albumin with embodiment 1 for the present embodiment.Specifically：
A kind of Thermosensitive Material Used for Controlled Releasing of Medicine is prepared by following component with parts by weight：1 part of polycaprolactone, 1 part of glycolic, garlic oil 2
Part, 0.5 part of sodium tripolyphosphate, 1 part of aloe polysaccharide, 3 parts of low-molecular weight chitoglycan, 2 parts of polyanion cellulose, the bis- oil of N, N'-
1 part of Ethylene Diamine diethyl sodium sulfonate, 5 parts of polyethylene glycol, 2 parts of glutaraldehyde, 50 parts of deionized water.
The preparation method of said medicine slow-release material is：
(1) low-molecular weight chitoglycan, polyanion cellulose, polycaprolactone, glycolic, aloe polysaccharide and deionized water are mixed
20min is stirred, obtains component A；
(2) 10min is mixed in garlic oil, N, the bis- oleoyl ethylenediamine diethyl sodium sulfonates of N'- and polyethylene glycol, obtains component B；
(3) component A and B are mixed, ultrasonic shear 5min；
(4) sodium tripolyphosphate and glutaraldehyde are added in, is heated to 40 DEG C of stirring 5h；
(5) water phase is obtained after standing separation, adjusts pH value to 8, low-speed centrifugal removes larger particle；
(6) suspension pH value is adjusted to neutrality, is centrifuged 3min under rotating speed 2500r/min, is discarded solvent, is drying to obtain.
Comparative example 2
Difference lies in do not contain polycaprolactone and glycolic with embodiment 1 for the present embodiment.Specifically：
A kind of Thermosensitive Material Used for Controlled Releasing of Medicine is prepared by following component with parts by weight：It is 0.5 part of silk peptide, 1 part of bovine serum albumin, big
2 parts of garlic oil, 0.5 part of sodium tripolyphosphate, 1 part of aloe polysaccharide, 3 parts of low-molecular weight chitoglycan, 2 parts of polyanion cellulose, N, N'-
Double 1 part of oleoyl ethylenediamine diethyl sodium sulfonates, 5 parts of polyethylene glycol, 2 parts of glutaraldehyde, 50 parts of deionized water.
The preparation method of said medicine slow-release material is：
(1) low-molecular weight chitoglycan, polyanion cellulose, silk peptide, bovine serum albumin, aloe polysaccharide and deionized water are mixed
Stirring 20min is closed, obtains component A；
(2) 10min is mixed in garlic oil, N, the bis- oleoyl ethylenediamine diethyl sodium sulfonates of N'- and polyethylene glycol, obtains component B；
(3) component A and B are mixed, ultrasonic shear 5min；
(4) sodium tripolyphosphate and glutaraldehyde are added in, is heated to 40 DEG C of stirring 5h；
(5) water phase is obtained after standing separation, adjusts pH value to 8, low-speed centrifugal removes larger particle；
(6) suspension pH value is adjusted to neutrality, is centrifuged 3min under rotating speed 2500r/min, is discarded solvent, is drying to obtain.
The partial properties index of the Thermosensitive Material Used for Controlled Releasing of Medicine of the present invention see the table below, it will be seen that material of the present invention is with higher
Water absorption rate, reach as high as 44.4%, hydrophily is good, and envelop rate is high, reaches as high as 94.1%, drug release rate is minimum in 2h
In only 26.2%, 8h drug release rate be only in 57.4%, 16h drug release rate be 79.6%, interior drug release is basic for 24 hours
It completes, there is good sustained drug release effect, the most suitable for 1/drug for 24 hours.
The partial properties index of 1 Thermosensitive Material Used for Controlled Releasing of Medicine of table
Claims (6)
1. a kind of Thermosensitive Material Used for Controlled Releasing of Medicine, it is characterised in that：It is prepared by following component with parts by weight：0.5-1.5 parts of silk peptide,
1-2 parts of polycaprolactone, 1-3 parts of bovine serum albumin, 1-2 parts of glycolic, 2-4 parts of garlic oil, 0.5-1 parts of sodium tripolyphosphate, aloe
1-2 parts of polysaccharide, 3-6 parts of low-molecular weight chitoglycan, 2-3 parts of polyanion cellulose, bis- two ethanesulfonic acids of oleoyl ethylenediamine of N, N'-
1-3 parts of sodium, 5-7 parts of polyethylene glycol, 2-4 parts of glutaraldehyde, 50-70 parts of deionized water.
2. a kind of Thermosensitive Material Used for Controlled Releasing of Medicine according to claim 1, it is characterised in that：By following component with parts by weight prepare and
Into：1 part of silk peptide, 1.5 parts of polycaprolactone, 2 parts of bovine serum albumin, 1.5 parts of glycolic, 3 parts of garlic oil, sodium tripolyphosphate 0.8
Part, 1.5 parts of aloe polysaccharide, 4.5 parts of low-molecular weight chitoglycan, 2.5 parts of polyanion cellulose, the bis- oleoyl ethylenediamines of N, N'-
2 parts of diethyl sodium sulfonate, 6 parts of polyethylene glycol, 3 parts of glutaraldehyde, 60 parts of deionized water.
3. a kind of Thermosensitive Material Used for Controlled Releasing of Medicine according to claim 1, it is characterised in that：The weight of the low-molecular weight chitoglycan is equal
Molecular weight is 4.8 × 104, deacetylation 92%.
4. a kind of preparation method of Thermosensitive Material Used for Controlled Releasing of Medicine of claim 1 to 2 any one of them, it is characterised in that：Including following
Step：
（1）By low-molecular weight chitoglycan, polyanion cellulose, silk peptide, polycaprolactone, bovine serum albumin, glycolic, reed
20-30min is mixed in luxuriant growth polysaccharide and deionized water, obtains component A；
（2）By garlic oil, N, 10-20min is mixed in the bis- oleoyl ethylenediamine diethyl sodium sulfonates of N'- and polyethylene glycol, obtains group
Divide B；
（3）Component A and B are mixed, ultrasonic shear 5-10min；
（4）Sodium tripolyphosphate and glutaraldehyde are added in, is heated to 40-50 DEG C of stirring 5-6h；
（5）Water phase is obtained after standing separation, adjusts pH value to 8, low-speed centrifugal removes larger particle；
（6）Suspension pH value is adjusted to neutrality, 3-5min is centrifuged under rotating speed 2500-3000r/min, discards solvent, drying is
.
5. a kind of preparation method of Thermosensitive Material Used for Controlled Releasing of Medicine according to claim 4, it is characterised in that：The step（4）In
45 DEG C are heated to, mixing time 5.5h.
6. a kind of preparation method of Thermosensitive Material Used for Controlled Releasing of Medicine according to claim 4, it is characterised in that：The step（6）In
Rotating speed is 2800r/min, centrifugation time 4min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201810033600.6A CN108159428A (en) | 2018-01-11 | 2018-01-11 | A kind of Thermosensitive Material Used for Controlled Releasing of Medicine and preparation method thereof |
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|---|---|---|---|
| CN201810033600.6A CN108159428A (en) | 2018-01-11 | 2018-01-11 | A kind of Thermosensitive Material Used for Controlled Releasing of Medicine and preparation method thereof |
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| CN108159428A true CN108159428A (en) | 2018-06-15 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111374987A (en) * | 2020-02-29 | 2020-07-07 | 湖北工业大学 | Method for improving foaming property and foam stability of serum albumin by using chitosan oligosaccharide |
-
2018
- 2018-01-11 CN CN201810033600.6A patent/CN108159428A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111374987A (en) * | 2020-02-29 | 2020-07-07 | 湖北工业大学 | Method for improving foaming property and foam stability of serum albumin by using chitosan oligosaccharide |
| CN111374987B (en) * | 2020-02-29 | 2021-08-24 | 湖北工业大学 | Method for improving foaming property and foam stability of serum albumin by using chitosan oligosaccharide |
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Application publication date: 20180615 |