CN108159073A - A kind of Calci-Mix - Google Patents
A kind of Calci-Mix Download PDFInfo
- Publication number
- CN108159073A CN108159073A CN201810232938.4A CN201810232938A CN108159073A CN 108159073 A CN108159073 A CN 108159073A CN 201810232938 A CN201810232938 A CN 201810232938A CN 108159073 A CN108159073 A CN 108159073A
- Authority
- CN
- China
- Prior art keywords
- calcium
- mix
- calcium carbonate
- calci
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
Abstract
The present invention provides formula and the preparation of a kind of Calci-Mix, and the formula of Calci-Mix of the present invention, by calcium carbonate and calcium acetate as active constituents of medicine, the two weight ratio is 9 10：1, Calci-Mix of the invention, preparation method is：9 10 parts by weight of calcium carbonate and 1 parts by weight of calcium acetate directly mix, and spray into ethanol in proper amount and pelletize as wetting agent, and the particle of preparation is packed into capsule, without other auxiliary materials.
Description
Technical field
The present invention relates to Medicines and Health Product field, more particularly to a kind of calcium supplement, the formula and system of Calci-Mix
It is standby.
Background technology
Existing calcium carbonate product is varied, and wherein Calci-Mix is used to prevent and treat calcium deficiency as medicine of replenishing the calcium
Disease, suitable for the crowds such as pregnant and lactating women, old man, children replenish the calcium and the treatment of osteoporosis, it can also be used to neutralize stomach
Acid.
Calcium is to maintain human nerve, muscle, skeletal system, cell membrane and capillary permeability normal function institute required,
The main ingredient of animal skeleton or shell is exactly calcium carbonate.The calcium carbonate used in medicinal and edible addition be using calcite and
Be made, due to purified, sterilization, filtering, it is refined after there is calcium supplementing effect, as additive in food, to ensure human body institute
The intake of necessary calcium, such as chewing gum, chocolate and Wahaha, it is huge can calcium, jelly happiness youth's beverage in make hardening agent, reach people
Demand of the body to calcium.As drug of replenishing the calcium, the calcium carbonate content in unit dose is larger, causes tablet or glue for existing calcium carbonate
The dosage forms such as capsule it is oversized, in addition, daily required dosage is higher, to patient take generation come it is inconvenient.For example, it generally takes
Amount needs 1000mg on the one or so, in addition the amount bigger after auxiliary material.
Calcareous absorption greatly depends on the form of calcium.Calcium carbonate trap is low, and calcium acetate bioavailability is higher than
3 times of calcium carbonate, and calcium acetate is taken merely, side effect is big, costly, prepares difficulty, and calcium carbonate raw material is easy to get, and prepares letter
It is single, it is at low cost, and Small side effects, for the present invention on the basis of existing calcium carbonate, proposition adds in setting for a small amount of calcium acetate thus
Think, devise a kind of method that minute quantity calcium acetate is added in calcium carbonate, such as add in the calcium acetate of 1/10 or so weight, it is unexpected
Discovery, can greatly improve calcium carbonate bioavailability, the daily dosage of calcium carbonate can be reduced, to patient with
To facilitate, while do not generate the side effect of calcium acetate.
Invention content
The present invention provides formula and the preparation of a kind of Calci-Mix, the formula of Calci-Mix of the present invention, by carbon
As active constituents of medicine, the two weight ratio is 9-10 for sour calcium and calcium acetate：1.
The Calci-Mix of the present invention, preparation method are：
Calcium carbonate 9-10 parts by weight and 1 parts by weight of calcium acetate directly mix, and spray into ethanol in proper amount and pelletize as wetting agent, preparation
Particle is packed into capsule, without other auxiliary materials,
Preferably, contain 90mg calcium carbonate and 10mg calcium acetates in every capsule of the invention.
Preferably, contain 95mg calcium carbonate and 5mg calcium acetates in every capsule of the invention.
It is wherein most preferably in every capsule and contains 95mg calcium carbonate and 5mg calcium acetates.
The present invention is found surprisingly that minute quantity calcium acetate is added in calcium carbonate can make calcium carbonate bioavailability big
It is big to improve, reduce every consumption per day of calcium carbonate, it has also been found that, the content for increasing calcium acetate does not greatly improve the life of calcium
Object availability, therefore the effect that is greatly improved bioavilability one times is added in a small amount of calcium acetate in calcium carbonate.
Illustrate beneficial effects of the present invention below by way of experimental data：
Experiment 1, urinary calcium total excretion are two kinds of preparation absorption differences of metrics evaluation with urinary calcium increment
Of the present invention group：
Healthy volunteer takes Calci-Mix 1000mg of the present invention,
Prior art group：
Healthy volunteer takes ordinary calcium carbonate capsule 1000mg,
The urine after calcium carbonate of the present invention and ordinary calcium carbonate capsule is taken orally with 10 healthy volunteers of aas determination
Calcium concentration, using urinary calcium total excretion and urinary calcium increment as two kinds of preparation absorption differences of metrics evaluation.
As a result:4 h urinary calcium total excretions are respectively 0.162 after oral 1000mg ordinary calcium carbonates and calcium carbonate of the present invention
- 1 and 0.103 mg (mg Cr) -1 of mg (mg Cr);
Urinary calcium increment is respectively -1 and 0.030 mg (mg Cr) -1 of 0.061 mg (mg Cr),
The former is all remarkably higher than the latter (P ＜ 0.05 and P ＜ 0.01)
Conclusion:Oral administration biaavailability of the present invention is higher than one times of of ordinary calcium carbonate capsule
Experiment 2, recipe determination comparative studies：
Experimental method, grouping：
1 group：Healthy volunteer takes Calci-Mix 1000mg, and the wherein weight ratio of calcium carbonate and calcium acetate is 1:1
2 groups：Healthy volunteer takes Calci-Mix 1000mg, and the wherein weight ratio of calcium carbonate and calcium acetate is 2:1
3 groups：Healthy volunteer takes Calci-Mix 1000mg, and the wherein weight ratio of calcium carbonate and calcium acetate is 4:1
4 groups：Healthy volunteer takes Calci-Mix 1000mg, and the wherein weight ratio of calcium carbonate and calcium acetate is 8:1
5 groups：Healthy volunteer takes Calci-Mix 1000mg, and the wherein weight ratio of calcium carbonate and calcium acetate is 10:1
6 groups：Healthy volunteer takes Calci-Mix 1000mg, and the wherein weight ratio of calcium carbonate and calcium acetate is 12:1
As a result such as following table
The result shows that adding in the calcium acetate of different proportion, acquired results are shown, the concentration of calcium is not with acetic acid calcium content in urine
Increase and dramatically increase, it is believed that only need a small amount of calcium acetate for adding in 1,10 ratios, you can reach remarkable result.
Specific embodiment
It further illustrates the present invention by the following examples
Embodiment 1
Calci-Mix, preparation method are：
Calcium carbonate 90mg and calcium acetate 10mg are directly mixed, and are sprayed into ethanol in proper amount and are pelletized as wetting agent, and the particle of preparation is packed into
Capsule.
Embodiment 2
Calci-Mix, preparation method are：
Calcium carbonate 95mg and calcium acetate 5mg are directly mixed, and are sprayed into ethanol in proper amount and are pelletized as wetting agent, and the particle of preparation is packed into glue
Capsule.
Claims (4)
1. a kind of Calci-Mix, which is characterized in that by calcium carbonate and calcium acetate as active constituents of medicine, the two weight ratio
For 9-10：1.
2. Calci-Mix according to claim 1, which is characterized in that by calcium carbonate and calcium acetate as pharmaceutical activity into
Point, 90mg calcium carbonate and 10mg calcium acetates are contained in every capsule.
3. Calci-Mix according to claim 1, which is characterized in that by calcium carbonate and calcium acetate as pharmaceutical activity into
Point, 95mg calcium carbonate and 5mg calcium acetates are contained in every capsule.
4. the preparation method of Calci-Mix described in claim 1, it is characterised in that step is as follows：
Calcium carbonate 9-10 parts by weight and 1 parts by weight of calcium acetate directly mix, and spray into ethanol in proper amount and pelletize as wetting agent, preparation
Particle is packed into capsule, without other auxiliary materials.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810232938.4A CN108159073A (en) | 2018-03-21 | 2018-03-21 | A kind of Calci-Mix |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810232938.4A CN108159073A (en) | 2018-03-21 | 2018-03-21 | A kind of Calci-Mix |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108159073A true CN108159073A (en) | 2018-06-15 |
Family
ID=62512108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810232938.4A Pending CN108159073A (en) | 2018-03-21 | 2018-03-21 | A kind of Calci-Mix |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108159073A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112675194A (en) * | 2020-09-12 | 2021-04-20 | 辽宁千里明药业(集团)有限公司 | Calcium supplement composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1205878A (en) * | 1998-07-30 | 1999-01-27 | 万海翔 | Compound super-energy calcium |
-
2018
- 2018-03-21 CN CN201810232938.4A patent/CN108159073A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1205878A (en) * | 1998-07-30 | 1999-01-27 | 万海翔 | Compound super-energy calcium |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112675194A (en) * | 2020-09-12 | 2021-04-20 | 辽宁千里明药业(集团)有限公司 | Calcium supplement composition |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20090155392A1 (en) | Methods and Systems for Sublingual Guarana Administration | |
| WO2005097085A1 (en) | Nutrient system for individualized responsive dosing regimens | |
| WO2014187196A1 (en) | Biogas residue-containing feed additive for dairy cattle | |
| CN102266299A (en) | Composition chewing tablets for a zinc gluconate compound and preparation method thereof | |
| WO2014183508A1 (en) | Biogas residue-containing formula feed for chicken | |
| CN103238841A (en) | Food composition containing Maca and saussurea involucrata culture and application thereof | |
| CN108159073A (en) | A kind of Calci-Mix | |
| JP2004256513A (en) | Agent for increasing amount of muscle | |
| JP2004175701A (en) | Mineral absorption promoter | |
| CN104739964B (en) | A kind of snail sobering preparation and preparation method thereof | |
| CN108420890B (en) | Composition with blood fat reducing effect and preparation method thereof | |
| CN103239480B (en) | Calcium supplement for animals and chewable tablets of calcium supplement | |
| CN105533699A (en) | Compound for supplementing zinc and vitamin in children as well as preparation method and application thereof | |
| CN104585763A (en) | Liver-protecting and liver-nourishing functional food and preparation method thereof | |
| CN102626420B (en) | Mixed preparation containing strontium, calcium and vitamin D | |
| WO2013006982A1 (en) | Dietetic multi-component system | |
| CN100398113C (en) | Nano selenium of Melatonin and its preparation method | |
| CN107595829B (en) | A kind of composition for preventing and treating renal osteodystrophy | |
| JP2004123671A (en) | Nutrient agent and digestive tract agent | |
| CN1081031C (en) | Calcium tablet | |
| CN103704684A (en) | Bone health product | |
| CN101045135A (en) | Medicine use for improving memory and treating senile dementia due to encephalatrophy | |
| JP3088707B2 (en) | Absorption inhibitor | |
| US20060165846A1 (en) | Nutritional supplement containing honey | |
| UA127072C2 (en) | MIXTURE FOR ENTERAL NUTRITION FOR PERSONS OF THE OLDER AGE GROUPS WITH DIABETES DISEASE |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180615 |